Melanie Odenkirk

Works (10)

Updated: February 27th, 2024 05:00

2024 article

Deciphering ApoE Genotype-Driven Proteomic and Lipidomic Alterations in Alzheimer's Disease Across Distinct Brain Regions

Odenkirk, M. T., Zheng, X., Kyle, J. E., Stratton, K. G., Nicora, C. D., Bloodsworth, K. J., … Baker, E. S. (2024, January 18). JOURNAL OF PROTEOME RESEARCH.

By: M. Odenkirk n, X. Zheng *, J. Kyle *, K. Stratton *, C. Nicora *, K. Bloodsworth *, C. Mclean *, C. Masters * ...

author keywords: Alzheimer's disease; proteomics; lipidomics; apolipoprotein E (APOE)
TL;DR: The region-specific influences of apolipoprotein E on AD mechanisms showcased mitochondrial dysfunction and cell proteostasis at the core of AD pathophysiology in the post-mortem brains, indicating these two processes may be influenced by genotypic differences and brain morphology. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (OpenAlex)
Source: Web Of Science
Added: February 26, 2024

2023 article

Combining native mass spectrometry and lipidomics to uncover specific membrane protein-lipid interactions from natural lipid sources

Zhu, Y., Odenkirk, M. T., Qiao, P., Zhang, T., Schrecke, S., Zhou, M., … Laganowsky, A. (2023, July 21). CHEMICAL SCIENCE.

By: Y. Zhu  n, M. Odenkirk*, P. Qiao*, T. Zhang *, S. Schrecke *, M. Zhou *, M. Marty *, E. Baker *, A. Laganowsky *

TL;DR: The results reveal that the bacterial ammonia channel (AmtB) enriches specific cardiolipin (CDL) and phosphatidylethanolamine (PE) from natural headgroup extracts and TRAAK, a two-pore domain K+ channel (K2P), retains specific acyl chains that is independent of the headgroup. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Source: Web Of Science
Added: August 7, 2023

2022 article

Assessing the Fate of Dissolved Organic Compounds in Landfill Leachate and Wastewater Treatment Systems

Doyle, M. G., Odenkirk, M. T., Stewart, A. K., Nelson, J. P., Baker, E. S., & Cruz, F. (2022, November 1). ACS ES&T WATER, Vol. 11.

By: M. Doyle n, M. Odenkirk n, A. Stewart n, J. Nelson  n, E. Baker n  & F. Cruz  n

author keywords: nontargeted analysis; anthropogenic chemicals; wastewater; landfill leachate; reverse osmosis
UN Sustainable Development Goal Categories
6. Clean Water and Sanitation (OpenAlex)
Sources: Web Of Science, ORCID, NC State University Libraries
Added: November 2, 2022

2022 journal article

Cupric Ions Selectively Modulate TRAAK-Phosphatidylserine Interactions

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 144(16), 7048–7053.

By: Y. Zhu *, S. Schrecke *, S. Tang *, M. Odenkirk n, T. Walker*, L. Stover *, J. Lyu*, T. Zhang * ...

MeSH headings : Cations, Divalent / metabolism; Phosphatidylserines; Potassium Channels, Tandem Pore Domain / chemistry; Potassium Channels, Tandem Pore Domain / metabolism
TL;DR: High-resolution native mass spectrometry enables the determination of equilibrium binding constants for distinct Cu2+-bound stoichiometries and uncovered the highest coupling factor corresponds to a 1:1 PS-to-Cu2+ ratio, which brings forth the role of cupric ions as an essential cofactor in selective TRAAK-PS interactions. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Sources: Web Of Science, NC State University Libraries
Added: June 6, 2022

2022 article

Impacts of Gestational FireMaster 550 (FM 550) Exposure on the Neonatal Cortex are Sex Specific and Largely Attributable to the Organophosphate Esters

Witchey, S. K., Doyle, M. G., Fredenburg, J. D., St Armour, G., Horman, B., Odenkirk, M. T., … Patisaul, H. B. (2022, September 8). NEUROENDOCRINOLOGY, Vol. 9.

By: S. Witchey n, M. Doyle n, J. Fredenburg n, G. St Armour n, B. Horman n, M. Odenkirk n, D. Aylor n, E. Baker n , H. Patisaul n 

TL;DR: This study reveals multiple mechanisms by which the components of a common FR mixture are developmentally neurotoxic and that the OPFRs may be the compounds of greatest concern. (via Semantic Scholar)
Sources: Web Of Science, NC State University Libraries
Added: September 26, 2022

2021 journal article

From Prevention to Disease Perturbations: A Multi-Omic Assessment of Exercise and Myocardial Infarctions

BIOMOLECULES, 11(1).

By: M. Odenkirk n, K. Stratton *, L. Bramer *, B. Webb-Robertson*, K. Bloodsworth *, M. Monroe *, K. Burnum-Johnson *, E. Baker n 

author keywords: lipidomics; metabolomics; multi-omics; planned myocardial infarction (PMI); myocardial infarction (MI); exercise; heart; cheminformatics
MeSH headings : Exercise; Exercise Test; Female; Humans; Lipidomics; Lipids / blood; Lipids / genetics; Male; Metabolomics; Middle Aged; Myocardial Infarction / blood; Myocardial Infarction / genetics; Myocardial Infarction / physiopathology; Myocardial Infarction / prevention & control; Risk Factors
TL;DR: Different lipidomic perturbations were observed for these events, as could be expected from their vastly different stresses on the body, and these results were combined with previously published metabolomic characterizations of the same patients to give a more holistic understanding of the molecular changes associated with each. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (Web of Science; OpenAlex)
Sources: Web Of Science, ORCID, NC State University Libraries
Added: January 4, 2021

2021 journal article

Multiomic Big Data Analysis Challenges: Increasing Confidence in the Interpretation of Artificial Intelligence Assessments

ANALYTICAL CHEMISTRY, 93(22), 7763–7773.

By: M. Odenkirk n, D. Reif n  & E. Baker n 

MeSH headings : Artificial Intelligence; Big Data; Data Analysis
TL;DR: The present and future capabilities of AI techniques in multiomic studies are discussed while introducing analytical checks and balances to validate the computational conclusions. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Sources: Web Of Science, NC State University Libraries
Added: July 19, 2021

2020 journal article

Structural-based connectivity and omic phenotype evaluations (SCOPE): a cheminformatics toolbox for investigating lipidomic changes in complex systems

ANALYST, 145(22), 7197–7209.

By: M. Odenkirk n, P. Zin n , J. Ash n, D. Reif n , D. Fourches n & E. Baker n 

MeSH headings : Cheminformatics; Lipidomics; Lipids; Mass Spectrometry; Phenotype
TL;DR: A Structural-based Connectivity and Omic Phenotype Evaluations (SCOPE) cheminformatics toolbox to aid in these evaluations of lipid species and their respective biological roles is developed. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Sources: Web Of Science, NC State University Libraries
Added: November 24, 2020

2020 journal article

Unveiling molecular signatures of preeclampsia and gestational diabetes mellitus with multi-omics and innovative cheminformatics visualization tools

MOLECULAR OMICS, 16(6).

By: M. Odenkirk n, K. Stratton *, M. Gritsenko *, L. Bramer *, B. Webb-Robertson*, K. Bloodsworth *, K. Weitz *, A. Lipton* ...

MeSH headings : Case-Control Studies; Diabetes, Gestational / genetics; Female; Genomics; Humans; Lipidomics; Metabolic Networks and Pathways; Pre-Eclampsia / genetics; Pregnancy
TL;DR: The multi-omic evaluations performed here provide new insight into the end-stage molecular profiles of each disease, thereby supplying information potentially crucial for earlier diagnosis and treatments. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (Web of Science; OpenAlex)
5. Gender Equality (Web of Science)
Sources: Web Of Science, NC State University Libraries
Added: January 4, 2021

2020 article

Utilizing Drift Tube Ion Mobility Spectrometry for the Evaluation of Metabolites and Xenobiotics

ION MOBILITY-MASS SPECTROMETRY: METHODS AND PROTOCOLS, Vol. 2084, pp. 35–54.

By: M. Odenkirk n & E. Baker n 

Contributors: M. Odenkirk n & E. Baker n 

author keywords: Ion mobility spectrometry (IMS); Drift tube ion mobility spectrometry (DTIMS); Metabolomics; Exposomics; Collision cross section (CCS)
MeSH headings : Ion Mobility Spectrometry / methods; Metabolome; Metabolomics / methods; Xenobiotics / analysis
TL;DR: A review of relevant parameter considerations for DTIMS application with emphasis on xenobiotics and metabolomics isomer separations is presented. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Sources: Web Of Science, ORCID, NC State University Libraries
Added: December 5, 2019

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