Madelyn VanBlunk
College of Engineering
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Works (2)
Updated: April 5th, 2024 16:43
2023 article
Absorption rate governs cell transduction in dry macroporous scaffolds
VanBlunk, M., Srikanth, V., Pandit, S. S., Kuznetsov, A. V., & Brudno, Y. (2023, January 1). Biomaterials Science, Vol. 1.
MeSH headings : Tissue Scaffolds; Biocompatible Materials; Cell Differentiation; Porosity; Tissue Engineering / methods
topics (OpenAlex): CAR-T cell therapy research; Microfluidic and Bio-sensing Technologies; Viral Infectious Diseases and Gene Expression in Insects; RNA Interference and Gene Delivery
TL;DR:
The rate of liquid flow through the scaffolds, rather than pore size or stiffness, serves as a central regulator for efficient Drydux transduction, which provides a fast and inexpensive method for transducing cells for cellular therapy, including for the production of CAR T cells.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, NC State University Libraries
Added: March 13, 2023
2022 article
Fabrication and Use of Dry Macroporous Alginate Scaffolds for Viral Transduction of T Cells
VanBlunk, M., Agarwalla, P., Pandit, S., & Brudno, Y. (2022, September 9). Journal of Visualized Experiments, Vol. 9.
MeSH headings : Alginates; Calcium; Immunotherapy, Adoptive; Receptors, Chimeric Antigen; T-Lymphocytes; Tissue Engineering; Tissue Scaffolds
topics (OpenAlex): CAR-T cell therapy research; Virus-based gene therapy research; Viral Infectious Diseases and Gene Expression in Insects
TL;DR:
Dry macroporous alginate scaffolds serve as a cheaper and more convenient alternative to the conventional transduction method for CAR-T cells and are comparable to the transduction efficiency of spinoculation on retronectin-coated plates.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, NC State University Libraries
Added: January 30, 2023