Works (56)

Updated: May 2nd, 2024 05:05

2024 article

Measuring local pH at interfaces from molecular tumbling: A concept for designing EPR-active pH-sensitive labels and probes

Voinov, M. A., Nunn, N., Rana, R., Davidsson, A., Smirnov, A. I., & Smirnova, T. I. (2024, April 18). ORGANIC & BIOMOLECULAR CHEMISTRY, Vol. 4.

Sources: ORCID, Web Of Science, NC State University Libraries
Added: May 1, 2024

2021 article

EPR Oximetry with Nitroxides: Effects of Molecular Structure, pH, and Electrolyte Concentration

Voinov, M. A., Smirnova, T. I., & Smirnov, A. I. (2021, November 20). APPLIED MAGNETIC RESONANCE, Vol. 11.

UN Sustainable Development Goal Categories
6. Clean Water and Sanitation (OpenAlex)
Sources: ORCID, Web Of Science, NC State University Libraries
Added: November 20, 2021

2021 journal article

Myeloperoxidase-induced modification of HDL by isolevuglandins inhibits paraoxonase-1 activity

JOURNAL OF BIOLOGICAL CHEMISTRY, 297(3).

By: G. Aggarwal*, L. May-Zhang*, V. Yermalitsky*, S. Dikalov*, M. Voynov n, V. Amarnath*, V. Kon*, M. Linton*, K. Vickers*, S. Davies*

MeSH headings : Aryldialkylphosphatase / antagonists & inhibitors; Aryldialkylphosphatase / blood; Humans; Lipid Peroxidation / drug effects; Lipids / chemistry; Lipids / pharmacology; Lipoproteins, HDL / metabolism; Peroxidase / metabolism; Recombinant Proteins / blood; Recombinant Proteins / metabolism
TL;DR: In vitro models containing HDL, PON1, and MPO test the hypothesis that IsoLG formation by MPO and its subsequent modification of HDL contributes to MPO-mediated reductions in Pon1 activity, and support the notion that association of MPO with HDL leads to lower PON 1 activity in part via Iso LG-mediated modification of PON2. (via Semantic Scholar)
Sources: Web Of Science, ORCID, NC State University Libraries
Added: October 26, 2021

2019 journal article

A biradical-tagged phospholipid as a polarizing agent for solid-state MAS Dynamic Nuclear Polarization NMR of membrane proteins

Solid State Nuclear Magnetic Resonance, 100, 92–101.

By: D. Good*, M. Voinov n, D. Bolton*, M. Ward*, I. Sergeyev*, M. Caporini*, P. Scheffer*, A. Lo* ...

Contributors: D. Good*, M. Voinov n, D. Bolton*, M. Ward*, I. Sergeyev*, M. Caporini*, P. Scheffer*, A. Lo* ...

author keywords: Nuclear magnetic resonance; Dynamic nuclear polarization; Electron spin resonance; Biradical; Signal enhancement; Membrane protein; Lipid; Bilayer
MeSH headings : Glycerol / chemistry; Lipid Bilayers / chemistry; Magnetic Resonance Spectroscopy; Membrane Proteins / chemistry; Phospholipids / chemistry; Water / chemistry
TL;DR: Conformational changes and an inhomogeneous distribution of the lipid-based biradicals in lipid bilayers emerged as important factors to consider for further development of this matrix-free approach for DNP of membrane proteins. (via Semantic Scholar)
UN Sustainable Development Goal Categories
6. Clean Water and Sanitation (OpenAlex)
Sources: Crossref, ORCID, NC State University Libraries, Web Of Science
Added: May 28, 2019

2019 journal article

Dielectric and Electrostatic Properties of the Silica Nanoparticle-Water Interface by EPR of pH-Sensitive Spin Probes

JOURNAL OF PHYSICAL CHEMISTRY C, 123(49), 29972–29985.

Contributors: V. Perelygin n, M. Voinov n, A. Marek n, E. Ou n, J. Krim n, D. Brenner n, T. Smirnova n, A. Smirnov n

UN Sustainable Development Goal Categories
6. Clean Water and Sanitation (OpenAlex)
Sources: ORCID, Web Of Science, NC State University Libraries
Added: January 6, 2020

2019 journal article

Effect of Silica Support on Electrostatics of Lipid Interfaces in Nano-Bio Hybrid Systems

Biophysical Journal, 116(3), 81a.

By: E. Ou n, M. Voinov n, A. Irving n, A. Smirnov n & T. Smirnova n

Sources: Crossref, NC State University Libraries
Added: February 24, 2020

2019 journal article

Enhancing sensitivity of Double Electron-Electron Resonance (DEER) by using Relaxation-Optimized Acquisition Length Distribution (RELOAD) scheme

Journal of Magnetic Resonance, 298, 115–126.

Contributors: S. Milikisiyants n, M. Voinov n, A. Marek n, M. Jafarabadi n, J. Liu*, R. Han*, S. Wang*, A. Smirnov*

author keywords: PELDOR; DEER; EPR; Spin-labeling; Dipolar spectroscopy; Distance measurements
MeSH headings : Algorithms; Electron Spin Resonance Spectroscopy / methods; Gramicidin / chemistry; Leptospira; Models, Chemical; Models, Molecular; Rhodopsin / chemistry; Sensitivity and Specificity; Signal-To-Noise Ratio; Spin Labels
TL;DR: A novel albeit simple approach to improve DEER sensitivity and decrease data acquisition time by introducing the signal acquisition scheme based on RELaxation Optimized Acquisition (Length) Distribution (DEER-RELOAD). (via Semantic Scholar)
Sources: Crossref, ORCID, NC State University Libraries, Web Of Science
Added: February 18, 2019

2019 journal article

Liquid Metal Nanoparticles as Initiators for Radical Polymerization of Vinyl Monomers

ACS MACRO LETTERS, 8(11), 1522–1527.

By: J. Ma n, Y. Lin n, Y. Kim*, Y. Ko n, J. Kim*, K. Oh*, J. Sun*, C. Gorman n ...

Contributors: J. Ma n, Y. Lin n, Y. Kim*, Y. Ko n, J. Kim*, K. Oh*, J. Sun*, C. Gorman n ...

UN Sustainable Development Goal Categories
Sources: ORCID, Web Of Science, NC State University Libraries
Added: December 9, 2019

2018 journal article

Refocused Out-Of-Phase (ROOPh) DEER: A pulse scheme for suppressing an unmodulated background in double electron-electron resonance experiments

Journal of Magnetic Resonance, 293, 9–18.

author keywords: PDS; PELDOR; DEER; EPR; Spin-labeling; Dipolar spectroscopy; Distance measurements
TL;DR: An alternative detection scheme - a Refocused Out-Of-Phase DEER (ROOPh-DEER) - to acquire only the modulated fraction of the dipolar DEER signal to avoid the presence of a significant unmodulated fraction in the detected signal. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Sources: Crossref, ORCID, NC State University Libraries
Added: August 28, 2020

2018 journal article

Silica-Supported Lipid Bilayers: Electrostatic Effects at Lipid Interfaces as Reported by Spin-Labeling EPR

Biophysical Journal, 114(3), 96a.

Sources: Crossref, NC State University Libraries
Added: February 24, 2020

2018 journal article

Using Hyscore Spectroscopy of Nitroxides to Profile Water Content of Lipid Bilayers with 2 Å Spatial Resolution

Biophysical Journal, 114(3), 16a.

By: M. Chestnut n, S. Milikisiyants n, A. Koolivand n, M. Voynov n, T. Smirnova n & A. Smirnov n

UN Sustainable Development Goal Categories
6. Clean Water and Sanitation (OpenAlex)
Sources: Crossref, NC State University Libraries
Added: August 28, 2020

2017 journal article

Effect of Solution Ionic Strength on the pKa of the Nitroxide pH EPR Probe 2,2,3,4,5,5-Hexamethylimidazolidin-1-oxyl

Cell Biochemistry and Biophysics, 75(2), 185–193.

Contributors: K. Margita n, M. Voinov n & A. Smirnov n

author keywords: pH indicator; Ionic strength; Electrolyte; Potentiometric titration; EPR; pH-sensitive nitroxides
MeSH headings : Cyclic N-Oxides / chemistry; Electron Spin Resonance Spectroscopy; Hydrogen-Ion Concentration; Imidazolidines / chemistry; Molecular Probes / chemistry; Nitrogen Oxides / chemistry; Osmolar Concentration; Protons; Solutions; Spin Labels; Static Electricity; Water / chemistry
UN Sustainable Development Goal Categories
6. Clean Water and Sanitation (OpenAlex)
Sources: Crossref, ORCID, NC State University Libraries, Web Of Science
Added: August 6, 2018

2017 journal article

Effects of Silica Support on Dynamics of Transmembrane Peptides and Effective p K a of Ionisable Sidechains

Biophysical Journal, 112(3), 175a.

Sources: Crossref, NC State University Libraries
Added: February 24, 2020

2017 journal article

Glycol Chitosan Engineered Autoregenerative Antioxidant Significantly Attenuates Pathological Damages in Models of Age-Related Macular Degeneration

ACS Nano, 11(5), 4669–4685.

By: R. Mitra, R. Gao*, M. Zheng, M. Wu, M. Voinov n, A. Smirnov n, T. Smirnova n, K. Wang, S. Chavala*, Z. Han

Contributors: R. Mitra, R. Gao*, M. Zheng, M. Wu, M. Voinov n, A. Smirnov n, T. Smirnova n, K. Wang, S. Chavala*, Z. Han

author keywords: age-related macular degeneration; cerium oxide nanoparticles; antioxidant; reactive oxygen species; laser-induced choroidal neovascularization
MeSH headings : Animals; Antioxidants / pharmacology; Cerium / chemistry; Cerium / pharmacology; Choroidal Neovascularization / drug therapy; Choroidal Neovascularization / prevention & control; Disease Models, Animal; Human Umbilical Vein Endothelial Cells; Humans; Macular Degeneration / physiopathology; Macular Degeneration / therapy; Male; Mice; Mice, Inbred C57BL; Oxidative Stress / drug effects; Reactive Oxygen Species / metabolism; Reactive Oxygen Species / pharmacology; Vascular Endothelial Growth Factor A / metabolism
TL;DR: An engineered water-soluble, biocompatible, trackable nanoceria with enriched antioxidant activity to scavenge intracellular reactive oxygen species (ROS) is reported, which may offer a superior therapeutic effect to deal with oxidative stress induced pathogeneses, such as AMD. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Sources: Crossref, ORCID, NC State University Libraries, Web Of Science
Added: August 6, 2018

2017 journal article

IKMTSL-PTE, a Phospholipid-Based EPR Probe for Surface Electrostatic Potential of Biological Interfaces at Neutral pH: Effects of Temperature and Effective Dielectric Constant of the Solvent

The Journal of Physical Chemistry B, 121(11), 2443–2453.

By: M. Voinov n, C. Scheid n, I. Kirilyuk*, D. Trofimov* & A. Smirnov n

Contributors: M. Voinov n, C. Scheid n, I. Kirilyuk*, D. Trofimov* & A. Smirnov n

MeSH headings : 2-Propanol / chemistry; Electron Spin Resonance Spectroscopy; Glycerophospholipids / chemical synthesis; Glycerophospholipids / chemistry; Hydrogen-Ion Concentration; Imidazoles / chemical synthesis; Imidazoles / chemistry; Lipid Bilayers / chemistry; Micelles; Octoxynol / chemistry; Phosphatidylglycerols / chemistry; Solvents / chemistry; Spin Labels / chemical synthesis; Static Electricity; Temperature; Water / chemistry
TL;DR: The ionization transitions of IKMTSL-PTE with pKa values close to the neutral pH range make this lipidlike molecule a valuable spectroscopic EPR probe for studying the electrostatic phenomena at biological interfaces, including lipid bilayer/membrane protein systems, that could be unstable in the acidic pH range accessible by the previously available probes. (via Semantic Scholar)
UN Sustainable Development Goal Categories
6. Clean Water and Sanitation (OpenAlex)
Sources: Crossref, ORCID, NC State University Libraries, Web Of Science
Added: August 6, 2018

2017 journal article

Spin Probe Multi-Frequency EPR Study of Unprocessed Cotton Fibers

Cell Biochemistry and Biophysics, 75(2), 211–226.

Contributors: A. Marek n, M. Voinov n & A. Smirnov n

author keywords: Spin probes; Cotton fibers; Electron paramagnetic resonance spectroscopy; Multi-frequency EPR; High-field EPR; Multi-component spectral simulations
MeSH headings : Cellulose / chemistry; Cotton Fiber; Cyclic N-Oxides / chemistry; Electron Spin Resonance Spectroscopy; Least-Squares Analysis; Solvents / chemistry; Spin Labels; Temperature; Viscosity
TL;DR: One of the results of this study is a demonstration of a co-existence of cellulose nanodomains with different physicochemical properties such as polarity and microviscosity that are affected by solvents and temperature. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Sources: Crossref, ORCID, NC State University Libraries, Web Of Science
Added: August 6, 2018

2016 journal article

The Hydroxyl Radical is a Critical Intermediate in the Voltammetric Detection of Hydrogen Peroxide

Journal of the American Chemical Society, 138(8), 2516–2519.

Contributors: J. Roberts n, M. Voinov n, A. Schmidt n, T. Smirnova n & L. Sombers n

MeSH headings : Electrochemical Techniques / methods; Electron Spin Resonance Spectroscopy / methods; Hydrogen Peroxide / analysis; Hydrogen Peroxide / chemistry; Hydroxyl Radical / analysis; Hydroxyl Radical / chemistry; Pyrroles / chemistry; Spin Labels
TL;DR: Voltammetry was combined with electron paramagnetic resonance spectroscopy to identify and define the role of an oxygen-centered radical liberated during the oxidation of H2O2, and it was demonstrated that the hydroxyl radical is a principal contributor to the voltammetry of H1O2 as signal is attenuated when this species is trapped. (via Semantic Scholar)
Sources: Crossref, ORCID, NC State University Libraries, Web Of Science
Added: August 6, 2018

2015 journal article

Cysteine-Specific Labeling of Proteins with a Nitroxide Biradical for Dynamic Nuclear Polarization NMR

The Journal of Physical Chemistry B, 119(32), 10180–10190.

By: M. Voinov n, D. Good, M. Ward, S. Milikisiyants n, A. Marek n, M. Caporini*, M. Rosay*, R. Munro ...

Contributors: M. Voinov n, D. Good, M. Ward, S. Milikisiyants n, A. Marek n, M. Caporini*, M. Rosay*, R. Munro ...

MeSH headings : Anabaena; Cyclic N-Oxides / chemical synthesis; Cyclic N-Oxides / chemistry; Cysteine / chemistry; Glycerol / chemistry; Mesylates / chemical synthesis; Mesylates / chemistry; Molecular Structure; Mutation; Nitrogen Isotopes / chemistry; Nitrogen Oxides / chemical synthesis; Nitrogen Oxides / chemistry; Nuclear Magnetic Resonance, Biomolecular / methods; Propanols / chemistry; Protons; Sensory Rhodopsins / chemistry; Sensory Rhodopsins / genetics; Solvents / chemistry; Temperature; Water / chemistry
TL;DR: A new biradical is synthesized, ToSMTSL, which is based on the known DNP agent TOTAPOL, but also contains a thiol-specific methanethiosulfonate group to allow for incorporating this biradicals into a protein in a site-directed manner. (via Semantic Scholar)
UN Sustainable Development Goal Categories
6. Clean Water and Sanitation (OpenAlex)
Sources: Crossref, ORCID, NC State University Libraries, Web Of Science
Added: August 6, 2018

2015 chapter

Ionizable Nitroxides for Studying Local Electrostatic Properties of Lipid Bilayers and Protein Systems by EPR

In Methods in Enzymology (Vol. 564, pp. 191–217).

Contributors: M. Voinov n & A. Smirnov n

MeSH headings : Animals; Electron Spin Resonance Spectroscopy / methods; Humans; Hydrogen-Ion Concentration; Lipid Bilayers / chemistry; Nitrogen Oxides / analysis; Proteins / chemistry; Protons; Spin Labels; Static Electricity; Sulfhydryl Compounds / chemistry
TL;DR: Biophysical methods to probe local electrostatic potentials of proteins and lipid bilayer systems that are based on an observation of reversible protonation of nitroxides by electron paramagnetic resonance (EPR) are described. (via Semantic Scholar)
UN Sustainable Development Goal Categories
6. Clean Water and Sanitation (OpenAlex)
Source: ORCID
Added: December 4, 2020

2015 journal article

“Snorkeling” of the Charged Sidechain of a Transmembrane Peptide as Directly Observed by Double Electron-Electron Resonance Experiment

Biophysical Journal, 108(2), 203a.

By: M. Donohue n, M. Voynov n, S. Milikisiyants n, A. Smirnov n & T. Smirnova n

TL;DR: Experimental observations of “snorkeling” for nitroxide-modified side-chains upon protonation, its dependence upon the location along the transmembrane peptide helix, and how this snorkeling is affected by the membrane electrostatic surface potential are reported. (via Semantic Scholar)
UN Sustainable Development Goal Categories
7. Affordable and Clean Energy (OpenAlex)
Sources: Crossref, NC State University Libraries, ORCID
Added: August 28, 2020

2014 journal article

Curved Lipid Bilayers: Structure, Dynamics, Phase Properties and Surface Electrostatics

Biophysical Journal, 106(2), 221a.

By: A. Marek n, A. Koolivand n, D. Song n, M. Voinov n & A. Smirnov n

TL;DR: It is concluded that biologically relevant fluid bilayer phase allows for a larger variability in the lipid packing density in the triglyceride polar head group region than a more ordered gel phase. (via Semantic Scholar)
Sources: Crossref, NC State University Libraries, ORCID
Added: February 24, 2020

2014 journal article

Profiling the Dielectric Constant at the Membrane-Peptide Interface using Ionizable EPR Probes

Biophysical Journal, 106(2), 508a.

By: M. Donohue n, M. Voynov n, A. Smirnov n & T. Smirnova n

TL;DR: This work reports on employing pH-sensitive ionizable EPR labels to profile a heterogeneous dielectric environment along the α-helix of a WALP peptide integrated in a lipid bilayer, and for the first time measurements of local electrostatics at peptide-bilayer interface were based on direct distance measurements rather than on assumptions on the probe location. (via Semantic Scholar)
Sources: Crossref, NC State University Libraries, ORCID
Added: February 24, 2020

2013 journal article

Molecular pH Probes at a Protein-Lipid Interface: Assessment of Local Dielectric Environment for Transmembrane Peptide

Biophysical Journal, 104(2), 373a.

By: M. Donohue n, M. Voynov n, A. Smirnov n & T. Smirnova n

TL;DR: Measurements of local electrostatics at peptide-bilayer interface were based on direct distance measurements rather than on assumptions on the probe location, allowing us to estimate effective dielectric constant. (via Semantic Scholar)
Sources: Crossref, NC State University Libraries, ORCID
Added: February 24, 2020

2013 journal article

Surface Electrostatics and Peptide Binding to Lipid Bilayer of Defined Curvature

Biophysical Journal, 104(2), 98a.

TL;DR: Small unilamellar vesicles that are sized by extrusion through nanoporous filters as a model of convex membranes with accessible outer surface show that the surface electrostatic potential of lipid bilayers is affected by the curvature to a rather large degree. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Sources: Crossref, NC State University Libraries, ORCID
Added: August 28, 2020

2013 journal article

Surface Electrostatics of Lipid Bilayers by EPR of a pH-Sensitive Spin-Labeled Lipid

Biophysical Journal, 104(1), 106–116.

By: M. Voinov n, I. Rivera-Rivera n & A. Smirnov n

Contributors: M. Voinov n, I. Rivera-Rivera n & A. Smirnov n

MeSH headings : Dimyristoylphosphatidylcholine / chemistry; Electrolytes / chemistry; Electron Spin Resonance Spectroscopy; Hydrogen-Ion Concentration; Lipid Bilayers / chemistry; Lipids / chemistry; Molecular Probes / chemistry; Nitrogen Oxides / chemistry; Phosphatidylglycerols / chemistry; Spin Labels; Static Electricity; Surface Properties; Unilamellar Liposomes / chemistry
TL;DR: A new spin-probe electron paramagnetic resonance (EPR) approach for assessing the electrostatic surface potential of lipid bilayers that is based on a recently synthesized EPR probe (IMTSL-PTE) containing a reversibly ionizable nitroxide tag attached to the lipids' polar headgroup, which shows remarkable agreement with Gouy-Chapman theory. (via Semantic Scholar)
Sources: Crossref, ORCID, NC State University Libraries, Web Of Science
Added: August 6, 2018

2012 journal article

Chaperon and Lipid Composition Requirements for Transmembrane Insertion of CesA Helices 4 and 5

Biophysical Journal, 102(3), 440a.

TL;DR: It is shown that an alanine-rich and generally non-aggregating membrane-spanning α-helical WALP peptide could also play such a role: when co-inserted with CesA TMHs, WALp promotes formation of transmembrane α-helices and prevents TMHS aggregation. (via Semantic Scholar)
Sources: Crossref, NC State University Libraries, ORCID
Added: August 28, 2020

2012 journal article

In vitro cytotoxicity of nitroxyl radicals with respect: To tumor and diploid human cells and estimation of their antiviral activity

Antibiotiki i Khimioterapiya, 57(1-2), 3–12. http://www.scopus.com/inward/record.url?eid=2-s2.0-84874999709&partnerID=MN8TOARS

By: I. Kirilyuk, V. Svyatchenko, D. Morozov, E. Kazachinskaya, N. Kiselev, S. Bakunova, M. Voinov, V. Loktev, I. Grigoryev

Contributors: I. Kirilyuk, V. Svyatchenko, D. Morozov, E. Kazachinskaya, N. Kiselev, S. Bakunova, M. Voinov, V. Loktev, I. Grigoryev

Source: ORCID
Added: October 25, 2022

2012 journal article

Probing Dielectric and Hydrogen Bonding Gradients in Biological Membranes

Biophysical Journal, 102(3), 414a.

By: T. Smirnova n, M. Voynov n, O. Poluektov* & A. Smirnov n

TL;DR: An arsenal of advanced spin-labeling EPR methods are employed to profile heterogeneous dielectric and hydrogen bonding environment along the α-helical chain of an alanine-rich WALP peptide that is anchored in a lipid bilayer in a transmembrane orientation. (via Semantic Scholar)
UN Sustainable Development Goal Categories
6. Clean Water and Sanitation (OpenAlex)
Sources: Crossref, NC State University Libraries, ORCID
Added: February 24, 2020

2012 journal article

Unique oxidation of imidazolidine nitroxides by potassium ferricyanide: Strategy for designing paramagnetic probes with enhanced sensitivity to oxidative stress

Free Radical Research, 46(9), 1115–1122.

author keywords: nitroxide; sterically-hindered hydroxylamine; oxoammonium cation; electron paramagnetic resonance; redox probes; peroxyl radicals
MeSH headings : Cyclic N-Oxides / chemistry; Ferricyanides / chemistry; Imidazolidines / chemistry; Molecular Structure; Oxidation-Reduction; Oxidative Stress; Peroxides / chemistry
TL;DR: An unexpected oxidative fragmentation of the imidazolidine nitroxides containing hydrogen atom in the 4-position of the heterocycle (HIMD) by PF resulting in the loss of the EPR signal is reported. (via Semantic Scholar)
Source: ORCID
Added: October 25, 2022

2011 journal article

EPR detection of cellular and mitochondrial superoxide using cyclic hydroxylamines

Free Radical Research, 45(4), 417–430.

Contributors: S. Dikalov*, I. Kirilyuk*, M. Voinov n & I. Grigor'Ev*

author keywords: Superoxide; spin trap; cyclic hydroxylamine; intracellular; extracellular; EPR
MeSH headings : Anions / metabolism; Cations / metabolism; Cyclic N-Oxides / metabolism; Electron Spin Resonance Spectroscopy; Endothelial Cells / drug effects; Endothelial Cells / metabolism; Humans; Hydrocarbons, Cyclic / chemistry; Hydrocarbons, Cyclic / metabolism; Hydrophobic and Hydrophilic Interactions; Hydroxylamine / metabolism; Hydroxylamines / chemistry; Hydroxylamines / metabolism; Mitochondria / drug effects; Mitochondria / metabolism; Neutrophils / drug effects; Neutrophils / metabolism; Organophosphates / metabolism; Permeability; Piperidines / metabolism; Pyrrolidines / metabolism; Rotenone / pharmacology; Spin Trapping / methods; Static Electricity; Structure-Activity Relationship; Superoxides / analysis; Superoxides / metabolism; Tetradecanoylphorbol Acetate / pharmacology
TL;DR: Production of extracellular, intracellular and mitochondrial O2•− in neutrophils, cultured endothelial cells and isolated mitochondria is studied using a new set of cationic, anionic and neutral hydroxylamine spin probes with various lipophilicity and cell permeability to provide unique information about site-specific production of the O2-− radical. (via Semantic Scholar)
Source: ORCID
Added: October 25, 2022

2011 book

Spin labels and spin probes for measurements of local pH and electrostatics by EPR

In Electron Paramagnetic Resonance (Vol. 22, pp. 71–106).

By: M. Voinov & A. Smirnov

Contributors: M. Voinov & A. Smirnov*

UN Sustainable Development Goal Categories
Source: ORCID
Added: December 4, 2020

2011 journal article

Surface Electrostatics Associated with Lipid Bilayer Curvature

Biophysical Journal, 100(3), 505a.

By: M. Voinov, A. Marek, L. Li & A. Smirnov

TL;DR: The data indicate that the bilayer bending affects the local electrostatic potential and lipid fluctuation properties in a rather large degree and is likely associated with a mechanism for cellular machinery function. (via Semantic Scholar)
Sources: Crossref, NC State University Libraries, ORCID
Added: August 28, 2020

2011 journal article

Surface-Mediated Production of Hydroxyl Radicals as a Mechanism of Iron Oxide Nanoparticle Biotoxicity

Journal of the American Chemical Society, 133(1), 35–41.

By: M. Voinov n, J. Pagán n, E. Morrison n, T. Smirnova n & A. Smirnov n

Contributors: M. Voinov n, J. Pagán n, E. Morrison n, T. Smirnova n & A. Smirnov n

MeSH headings : Animals; Catalysis; Cattle; Cell Survival / drug effects; Electron Spin Resonance Spectroscopy; Ferric Compounds / chemistry; Ferric Compounds / toxicity; HeLa Cells; Humans; Hydrogen Peroxide / chemistry; Hydroxyl Radical / chemistry; Iron / chemistry; Nanoparticles / chemistry; Nanoparticles / toxicity; Oleic Acid / chemistry; Serum Albumin, Bovine / chemistry; Surface Properties
TL;DR: The experimental protocols developed in this study could be used as one of the approaches for developing analytical assays for assessing the free radical generating activity of a variety of nanomaterials that is potentially related to their biotoxicity. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Sources: Crossref, ORCID, NC State University Libraries, Web Of Science
Added: August 6, 2018

2010 journal article

Heterogeneous Dielectric and Hydrogen Bonding Environment of Transmembrane Peptides

Biophysical Journal, 98(3), 87a.

By: T. Smirnova n, M. Voynov n, O. Poluektov* & A. Smirnov n

TL;DR: It was concluded that such combination of EPR techniques significantly expands the capabilities of spin-labeling methods in studies of membrane proteins as demonstrated by deriving profiles of heterogeneous dielectric and hydrogen bonding environment along a typical transmembrane alpha-helix. (via Semantic Scholar)
Sources: Crossref, NC State University Libraries, ORCID
Added: February 24, 2020

2010 journal article

Surface Electrostatics and Lipid-Substrate Interactions of Nanopore-Confined Lipid Bilayers

Biophysical Journal, 98(3), 402a.

By: A. Marek n, M. Voinov n & A. Smirnov n

Sources: Crossref, NC State University Libraries, ORCID
Added: August 28, 2020

2009 journal article

Design of liposome-based pH sensitive nanoSPIN probes: nano-sized particles with incorporated nitroxides

The Analyst, 134(5), 904.

MeSH headings : Acidosis; Animals; Electrochemical Techniques; Electron Spin Resonance Spectroscopy / methods; Gramicidin / chemistry; Hydrogen-Ion Concentration; Ischemia; Liposomes / chemistry; Molecular Structure; Myocardium / metabolism; Nanoparticles / chemistry; Nitrogen Oxides / chemistry; Oxygen Consumption; Rats; Rats, Sprague-Dawley
TL;DR: An application of the pH-sensitive nanoSPIN in an ischemia model in rat heart homogenate allows for monitoring ischemIA-induced acidosis while protecting encapsulated nitroxide against bioreduction. (via Semantic Scholar)
Sources: Crossref, ORCID, NC State University Libraries
Added: March 27, 2022

2009 journal article

Spin-Labeled pH-Sensitive Phospholipids for Interfacial pKa Determination: Synthesis and Characterization in Aqueous and Micellar Solutions

The Journal of Physical Chemistry B, 113(11), 3453–3460.

Contributors: M. Voinov n, I. Kirilyuk n & A. Smirnov n

MeSH headings : Electrochemistry; Electron Spin Resonance Spectroscopy; Hydrogen-Ion Concentration; Indicators and Reagents; Kinetics; Mercaptoethanol / chemistry; Micelles; Models, Molecular; Nitrogen / chemistry; Phospholipids / chemistry; Solutions; Spin Labels; Water
TL;DR: The synthesis and characterization of spin-labeled phospholipids with pH-reporting nitroxides that are covalently attached to the lipid's polar headgroup are being reported, indicating that in mixed aqueous/organic solvents, the amphiphilic lipid molecules could be shielded from changing bulk conditions by a local shell of solvent molecules. (via Semantic Scholar)
UN Sustainable Development Goal Categories
6. Clean Water and Sanitation (OpenAlex)
Sources: Crossref, ORCID, NC State University Libraries, Web Of Science
Added: August 6, 2018

2009 journal article

Synthesis of N'-substituted amidines through the cleavage an oxadiazolone heterocycle by weakly basic nucleophiles. Effect of the nature of the nucleophile and of the nucleophile/substrate molar ratio

Chemistry of Heterocyclic Compounds, 45(1), 59–65.

By: Y. Polienko*, I. Grigor’yev* & M. Voinov n

Contributors: Y. Polienko*, I. Grigor'Yev* & M. Voinov n

author keywords: amidine; nucleophile; nitroxyl radicals; tetrahydroimidazo[1,5-b][1,2,4]oxadiazol-2-one; 1,3-dipolar cycloaddition; EPR spectroscopy
UN Sustainable Development Goal Categories
Sources: Crossref, ORCID, NC State University Libraries, Web Of Science
Added: August 6, 2018

2008 journal article

Interfacial Surface Properties of Thiol-Protected Gold Nanoparticles:  A Molecular Probe EPR Approach

Langmuir, 24(3), 609–612.

Contributors: V. Khlestkin n, J. Polienko n, M. Voinov n, A. Smirnov n & V. Chechik n

TL;DR: A molecular probe technique for accessing interfacial surface electrostatics of ligand-protected gold nanoparticles using a series of ligands with variable length of the hydrocarbon bridge between the anchoring sulfur and the reporting pH-sensitive nitroxide is presented. (via Semantic Scholar)
UN Sustainable Development Goal Categories
6. Clean Water and Sanitation (OpenAlex)
Sources: Crossref, ORCID, NC State University Libraries, Web Of Science
Added: August 6, 2018

2008 journal article

Mapping Local Protein Electrostatics by EPR of pH-Sensitive Thiol-Specific Nitroxide

Biochemistry, 47(20), 5626–5637.

By: M. Voinov n, A. Ruuge n, V. Reznikov, I. Grigor’ev & A. Smirnov n

Contributors: M. Voinov n, A. Ruuge n, V. Reznikov, I. Grigor'ev & A. Smirnov n

MeSH headings : Calibration; Electron Spin Resonance Spectroscopy; Hydrogen-Ion Concentration; Nitrogen Oxides / chemistry; Proteins / chemistry; Protons; Sensitivity and Specificity; Static Electricity; Sulfhydryl Compounds / chemistry; Titrimetry
TL;DR: It has been demonstrated that the high accuracy of pKa determination for pH-sensitive nitroxides could be achieved regardless of the frequency of measurements or the regime of spin exchange: fast at X-band and slow at W-band. (via Semantic Scholar)
Sources: Crossref, ORCID, NC State University Libraries, Web Of Science
Added: August 6, 2018

2008 journal article

Studies toward the Synthesis of 4-(2-R-ethyl)amino-2,2,5,5-tetramethyl-3-imidazoline 1-Oxyls. Nucleophilic Substitution of Bromide in the N-Alkyl Chain of the 1,2,4-Oxadiazol-2-one Precursor

The Journal of Organic Chemistry, 73(2), 502–510.

By: J. Polienko n, T. Schanding n, Y. Gatilov n, I. Grigor'ev n & M. Voinov n

Contributors: J. Polienko n, T. Schanding n, Y. Gatilov n, I. Grigor'ev n & M. Voinov n

MeSH headings : Bromides / chemistry; Electron Spin Resonance Spectroscopy / methods; Free Radicals / chemical synthesis; Free Radicals / chemistry; Hydrogen-Ion Concentration; Imidazoles / chemistry; Imidazolines / chemical synthesis; Imidazolines / chemistry; Models, Molecular; Molecular Structure; Oxazoles / chemistry; Stereoisomerism
TL;DR: A synthetic approach to access the new nitroxides of the amidine type exhibiting pH-dependent EPR spectra through substitution of a halide in the exo-N-halogenoalkyl chain of 1-(2-bromoethyl)-6-oxyl-5,5,7,7-tetramethyltetrahydroimidazo[1,5-b]oxadiazol-2-one is reported. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Sources: Crossref, ORCID, NC State University Libraries, Web Of Science
Added: August 6, 2018

2007 journal article

Local polarity and hydrogen bonding inside the Sec14p phospholipid-binding cavity: High-field multi-frequency electron paramagnetic resonance studies

BIOPHYSICAL JOURNAL, 92(10), 3686–3695.

Contributors: T. Smirnova n, T. Chadwick n, M. Voinov n, O. Poluektov*, J. Van Tol*, A. Ozarowski*, G. Schaaf*, M. Ryan*, V. Bankaitis*

MeSH headings : Binding Sites; Computer Simulation; Electron Spin Resonance Spectroscopy / methods; Hydrogen Bonding; Models, Chemical; Models, Molecular; Phospholipid Transfer Proteins / chemistry; Phospholipids / chemistry; Protein Binding; Saccharomyces cerevisiae Proteins / chemistry; Solvents / chemistry; Static Electricity
TL;DR: The data suggest the polarity gradient inside the Sec14p cavity is a significant contributor to the driving molecular forces for extracting a phospholipid from the bilayer and the enhanced g-factor resolution of EPR provides researchers with a spectroscopic tool to deconvolute two major contributions to the x-component of the nitroxide g-matrix: hydrogen-bond formation and local electrostatic effects. (via Semantic Scholar)
Sources: ORCID, Web Of Science, NC State University Libraries
Added: August 6, 2018

2007 journal article

α-Organoelement Nitrones:  Synthesis, Properties, and IR and 13C NMR Spectral and X-ray Structural Characterization

Organometallics, 26(7), 1607–1615.

By: M. Voinov*, T. Shevelev*, T. Rybalova*, Y. Gatilov*, N. Pervukhina, A. Burdukov*, I. Grigor'ev*

Contributors: M. Voinov*, T. Shevelev*, T. Rybalova*, Y. Gatilov*, N. Pervukhina, A. Burdukov*, I. Grigor'ev*

UN Sustainable Development Goal Categories
6. Clean Water and Sanitation (OpenAlex)
Sources: Crossref, ORCID, NC State University Libraries, Web Of Science
Added: August 6, 2018

2006 journal article

Improved Synthesis of 1‐Hydroxy‐2,2,5,5‐tetramethyl‐3‐imidazoline 3‐Oxide (HTIO)

Synthetic Communications, 36(19), 2763–2768.

By: J. Polienko*, T. Schanding*, M. Voinov* & I. Grigor'ev*

Contributors: J. Polienko*, T. Schanding*, M. Voinov* & I. Grigor'ev*

author keywords: aldonitrone; 2,2-dialkoxypropane; HTIO; 3-imidazoline 3-oxide; nitroxide
Sources: Crossref, ORCID, NC State University Libraries
Added: March 27, 2022

2005 journal article

NMR Spectra of Cyclic Nitrones. 7. The Influence of Substituents and a Hydrogen Bond on 14N and 17O Chemical Shifts in Derivatives of 3-Imidoazoline 3-Oxide

Chemistry of Heterocyclic Compounds, 41(9), 1134–1138.

By: I. Grigor'ev*, M. Voinov* & M. Fedotov*

Contributors: I. Grigor'ev*, M. Voinov* & M. Fedotov*

Sources: Crossref, ORCID, NC State University Libraries
Added: March 27, 2022

2005 journal article

Synthesis, Structure, and X-Band (9.5 GHz) EPR Characterization of the New Series of pH-Sensitive Spin Probes: N,N-Disubstituted 4-Amino-2,2,5,5-tetramethyl-3-imidazoline 1-Oxyls

The Journal of Organic Chemistry, 70(24), 9702–9711.

By: M. Voinov*, J. Polienko*, T. Schanding*, A. Bobko*, V. Khramtsov*, Y. Gatilov*, T. Rybalova*, A. Smirnov*, I. Grigor'ev*

Contributors: M. Voinov*, J. Polienko*, T. Schanding*, A. Bobko*, V. Khramtsov*, Y. Gatilov*, T. Rybalova*, A. Smirnov*, I. Grigor'ev*

MeSH headings : Electron Spin Resonance Spectroscopy / methods; Hydrogen-Ion Concentration; Imidazolines / chemical synthesis; Imidazolines / chemistry; Molecular Structure; X-Ray Diffraction
TL;DR: An alternative approach for pKa determination is demonstrated that is based on measuring the peak-to-peak line width of the EPR spectrum in the presence of the paramagnetic broadening agent potassium ferricyanide. (via Semantic Scholar)
UN Sustainable Development Goal Categories
6. Clean Water and Sanitation (OpenAlex)
Sources: Crossref, ORCID, NC State University Libraries, Web Of Science
Added: August 6, 2018

2004 journal article

Site-Directed Electrostatic Measurements with a Thiol-Specific pH-Sensitive Nitroxide:  Differentiating Local pK and Polarity Effects by High-Field EPR

Journal of the American Chemical Society, 126(29), 8872–8873.

By: A. Smirnov n, A. Ruuge n, V. Reznikov, M. Voinov n & I. Grigor'ev n

Contributors: A. Smirnov n, A. Ruuge n, V. Reznikov, M. Voinov n & I. Grigor'Ev n

MeSH headings : Electron Spin Resonance Spectroscopy / methods; Hydrogen-Ion Concentration; Imidazoles / chemistry; Kinetics; Mesylates / chemistry; Nitrogen Oxides / chemistry; Peptides / chemistry; Protein Folding; Spin Labels; Static Electricity; Sulfhydryl Compounds / chemistry
TL;DR: Using EPR at 95 GHz (W-band) isotropic magnetic parameters of this nitroxide, both Aiso and giso, were calibrated in solvents of different polarity and pH, making it possible to differentiate effects of local polarity from N3 protonation on nitroxides EPR spectra. (via Semantic Scholar)
UN Sustainable Development Goal Categories
6. Clean Water and Sanitation (OpenAlex)
Sources: Crossref, ORCID, NC State University Libraries, Web Of Science
Added: August 6, 2018

2002 journal article

A route to the synthesis of previously unknown α-heteroatom substituted nitrones

Tetrahedron Letters, 43(13), 2445–2447.

By: M. Voinov & I. Grigor’ev

Contributors: M. Voinov & I. Grigor'ev

author keywords: nitrones; synthesis; alpha-lithiation of aldonitrones; dipole-stabilized organolithiums; alpha-heteroatom substituted nitrones; IR; C-13 NMR spectroscopy
UN Sustainable Development Goal Categories
6. Clean Water and Sanitation (OpenAlex)
Source: ORCID
Added: October 25, 2022

2002 journal article

Dipole-stabilized carbanions in the series of cyclic aldonitrones 3.* The influence of the configuration of the nitrone group on H - D exchange of the methine hydrogen atom and metallation of aldonitrones

Russian Chemical Bulletin, 51(2), 283–290. http://www.scopus.com/inward/record.url?eid=2-s2.0-0141853817&partnerID=MN8TOARS

By: M. Voinov & I. Grigor’ev

Contributors: M. Voinov & I. Grigor'ev

Source: ORCID
Added: October 25, 2022

2001 journal article

Dipole-stabilized carbanions in series of cyclic aldonitrones: Part 4.<sup>13</sup>C, <sup>14</sup>N and<sup>7</sup>Li NMR spectra of dipole-stabilized organolithiums derived from a cyclic aldonitrone

Magnetic Resonance in Chemistry, 39(11), 681–683.

By: M. Voinov*, G. Salnikov*, A. Genaev*, V. Mamatyuk*, M. Shakirov & I. Grigor’Ev*

Contributors: M. Voinov*, G. Salnikov*, A. Genaev*, V. Mamatyuk*, M. Shakirov & I. Grigor'Ev*

author keywords: NMR; Li-7 NMR; C-13 NMR; N-14 NMR; chemical shifts; aldonitrones; lithiation; dipole-stabilized carbanions; carbenoid
Source: ORCID
Added: October 25, 2022

2000 journal article

Dipole-stabilized carbanions in series of cyclic aldonitrones. Part 2: Reactions of the metalated aldonitrones - Derivatives of 3-imidazoline 3- oxide and 2H-imidazole 1-oxide with aldehydes and ketones

Tetrahedron, 56(24), 4071–4077.

By: M. Voinov*, I. Grigor’Ev* & L. Volodarsky*

Contributors: M. Voinov*, I. Grigor'Ev* & L. Volodarsky*

author keywords: nitrones; metalation; dipole-stabilized organolithiums; 3-imidazoline 3-oxide; 2H-imidazole 1-oxide; 1,3-dipolar cycloaddition; alpha-hydroxymethyl nitrones
Source: ORCID
Added: October 25, 2022

1998 journal article

Detection of superoxide radicals and peroxynitrite by 1-hydvoxy-4-phosphonooxy-2,2,6,6-tetvamethylpipevidine: Quantification of extracellular superoxide radicals formation

Biochemical and Biophysical Research Communications, 248(2), 211–215.

By: S. Dikalov*, I. Grigor’ev*, M. Voinov* & E. Bassenge*

Contributors: S. Dikalov*, I. Grigor'ev*, M. Voinov* & E. Bassenge*

MeSH headings : Electron Spin Resonance Spectroscopy; Free Radical Scavengers / metabolism; Free Radicals / metabolism; Kinetics; Molecular Structure; Nitrates / analysis; Nitroglycerin / blood; Organophosphates / metabolism; Piperidines / metabolism; Pyrrolidines / metabolism; Spin Labels; Superoxide Dismutase / metabolism; Superoxides / analysis; Xanthine Oxidase / blood
TL;DR: PP-H is an effective scavenger of superoxide radical and of peroxynitrite, and can be used to quantify the extracellular formation of these reactive oxygen species. (via Semantic Scholar)
Source: ORCID
Added: October 25, 2022

1998 journal article

Dipole stabilized carbanions in series of cyclic aldonitrones. Part I (1). Aldonitrones metallation and dimerization in LDA and n-Buli solutions

Heterocyclic Communications, 4(3), 261–270.

By: M. Voinov*, I. Grigor’ev* & L. Volodarsky*

Contributors: M. Voinov*, I. Grigor'ev* & L. Volodarsky*

Source: ORCID
Added: October 25, 2022

1997 journal article

Synthesis and properties of N-[1-hydroxyimino-2-methyl-1-(2-pyridyl)prop-2-yl]hydroxyiamine and heterocyclic derivatives based on it

Russian Chemical Bulletin, 46(1), 126–132.

By: M. Voinov* & L. Volodarsky*

Contributors: M. Voinov* & L. Volodarsky*

author keywords: alpha-hydroxylamino oximes; N-[1-hydroxyimino-2-methyl-1-(2-pyridyl)prop-2-yl]hydroxylamine; 3-imidazoline 3-oxides; methylenenitrone, nitrones, nitroxyl radicals; pyridine
Source: ORCID
Added: October 25, 2022

1992 journal article

Reactions of aldonitrones (3-imidazoline-3-oxides) with isothiocyanates

Bulletin of the Russian Academy of Sciences Division of Chemical Science, 41(11), 2091–2095.

By: M. Voinov, V. Martin & L. Volodarskii

Contributors: M. Voinov, V. Martin & L. Volodarskii

author keywords: ALDONITRONES; 3-IMIDAZOLINE-3-OXIDE DERIVATIVES; ISOTHIOCYANATES
UN Sustainable Development Goal Categories
6. Clean Water and Sanitation (OpenAlex)
Source: ORCID
Added: October 25, 2022

1988 journal article

1,3-Dipolar cycloaddition of 3-imidazoline-3-oxide nitroxyl radical to dipolarophiles containing carbon-carbon double bonds

Bulletin of the Academy of Sciences of the USSR Division of Chemical Science, 37(8), 1677–1683.

By: V. Martin*, L. Volodarskii, M. Voinov*, T. Berezina* & T. Lelyukh*

Contributors: V. Martin*, L. Volodarskii, M. Voinov*, T. Berezina* & T. Lelyukh*

Source: ORCID
Added: October 25, 2022

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