Works (4)
Updated: August 13th, 2023 21:16
2010 journal article
Inference on treatment effects from a randomized clinical trial in the presence of premature treatment discontinuation: the SYNERGY trial
BIOSTATISTICS, 12(2), 258–269.
author keywords: Dynamic treatment regime; Inverse probability weighting; Potential outcomes; Proportional hazards model
MeSH headings : Acute Coronary Syndrome / drug therapy; Algorithms; Computer Simulation; Endpoint Determination; Enoxaparin / administration & dosage; Enoxaparin / adverse effects; Enoxaparin / therapeutic use; Hemorrhage / etiology; Heparin / administration & dosage; Heparin / adverse effects; Heparin / therapeutic use; Humans; Intention to Treat Analysis; Models, Statistical; Monte Carlo Method; Mortality; Multicenter Studies as Topic; Probability; Proportional Hazards Models; Randomized Controlled Trials as Topic / methods; Survival Analysis; Treatment Outcome; Withholding Treatment / statistics & numerical data
TL;DR:
The Superior Yield of the New Strategy of Enoxaparin, Revascularization, and GlYcoprotein IIb/IIIa inhibitors (SYNERGY) was a randomized, open-label, multicenter clinical trial comparing 2 anticoagulant drugs on the basis of time-to-event endpoints.
(via Semantic Scholar)
open access via academic.oup.com (publisher PDF)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018
2008 journal article
Improving efficiency of inferences in randomized clinical trials using auxiliary covariates
BIOMETRICS, 64(3), 707–715.
author keywords: covariate adjustment; hypothesis test; k-arm trial; Kruskal-Wallis test; log odds ratio; longitudinal data; semiparametric theory
MeSH headings : Acquired Immunodeficiency Syndrome / drug therapy; Analysis of Variance; Angina, Unstable / blood; Angina, Unstable / drug therapy; Anti-HIV Agents / therapeutic use; Anticoagulants / therapeutic use; Biometry / methods; Humans; Linear Models; Logistic Models; Models, Statistical; Monte Carlo Method; Odds Ratio; Platelet Glycoprotein GPIIb-IIIa Complex / metabolism; Randomized Controlled Trials as Topic / statistics & numerical data; Treatment Outcome
TL;DR:
Taking a semiparametric theory perspective, this work proposes a broadly applicable approach to adjustment for auxiliary covariates to achieve more efficient estimators and tests for treatment parameters in the analysis of randomized clinical trials.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018
2007 journal article
"Smooth" semiparametric regression analysis for arbitrarily censored time-to-event data
BIOMETRICS, 64(2), 567–576.
author keywords: accelerated failure time model; heteroscedasticity; information criteria; interval censoring; proportional hazards model; proportional odds model; seminonparametric (SNP) density; time-dependent covariates
MeSH headings : Biometry / methods; Computer Simulation; Data Interpretation, Statistical; Models, Statistical; Regression Analysis; Statistics, Nonparametric
TL;DR:
A general framework for regression analysis of time-to-event data subject to arbitrary patterns of censoring is proposed, which allows popular models, such as the proportional hazards, proportional odds, and accelerated failure time models, to be placed in a common framework and provides a principled basis for choosing among them.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018
2007 article
Covariate adjustment for two-sample treatment comparisons in randomized clinical trials: A principled yet flexible approach
Tsiatis, A. A., Davidian, M., Zhang, M., & Lu, X. (2008, October 15). STATISTICS IN MEDICINE, Vol. 27, pp. 4658–4677.
author keywords: baseline variables; clinical trials; covariate adjustment; efficiency; semiparametric theory; variable selection
MeSH headings : Algorithms; Data Interpretation, Statistical; Humans; Randomized Controlled Trials as Topic / statistics & numerical data; Sampling Studies; Statistics, Nonparametric; Treatment Outcome
TL;DR:
App appealing to the theory of semiparametrics is led naturally to a characterization of all treatment effect estimators and to principled, practically feasible methods for covariate adjustment that yield the desired gains in efficiency and that allow covariate relationships to be identified and exploited while circumventing the usual concerns.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018
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