@article{khan_mondino_russell_case_fefer_woods_olby_gruen_2023, title={A novel task of canine olfaction for use in adult and senior pet dogs}, volume={13}, ISSN={["2045-2322"]}, url={https://europepmc.org/articles/PMC9908929}, DOI={10.1038/s41598-023-29361-x}, abstractNote={Abstract}, number={1}, journal={SCIENTIFIC REPORTS}, author={Khan, Michael Z. and Mondino, Alejandra and Russell, Katharine and Case, Beth and Fefer, Gilad and Woods, Hope and Olby, Natasha and Gruen, Margaret}, year={2023}, month={Feb} }
 @article{mondino_khan_case_giovagnoli_thomson_lascelles_gruen_olby_2023, title={Activity patterns are associated with fractional lifespan, memory, and gait speed in aged dogs}, volume={13}, ISSN={["2045-2322"]}, url={https://europepmc.org/articles/PMC9929073}, DOI={10.1038/s41598-023-29181-z}, abstractNote={Abstract}, note={PMID: 36788306; PMCID: PMC9929073.}, number={1}, journal={SCIENTIFIC REPORTS}, author={Mondino, Alejandra and Khan, Michael and Case, Beth and Giovagnoli, Sara and Thomson, Andrea and Lascelles, B. Duncan X. and Gruen, Margaret and Olby, Natasha}, year={2023}, month={Feb} }
 @article{khan_mondino_russell_case_fefer_woods_olby_gruen_2023, title={Relationship between engagement with the impossible task, cognitive testing, and cognitive questionnaires in a population of aging dogs}, volume={9}, ISSN={["2297-1769"]}, DOI={10.3389/fvets.2022.1052193}, abstractNote={IntroductionThe aim of this study was to evaluate the engagement of aging dogs with a cognitively challenging and potentially frustrating task (the impossible task). Based on previous observations, we predicted that dogs showing signs of cognitive impairment in other cognitive tests and owner-completed questionnaires would show reduced engagement with the task.}, journal={FRONTIERS IN VETERINARY SCIENCE}, author={Khan, Michael Z. and Mondino, Alejandra and Russell, Katharine and Case, Beth and Fefer, Gilad and Woods, Hope and Olby, Natasha J. and Gruen, Margaret E.}, year={2023}, month={Jan} }
 @article{mondino_catanzariti_mateos_khan_ludwig_kis_gruen_olby_2023, title={Sleep and cognition in aging dogs. A polysomnographic study}, volume={10}, ISSN={["2297-1769"]}, DOI={10.3389/fvets.2023.1151266}, abstractNote={IntroductionSleep is fundamental for cognitive homeostasis, especially in senior populations since clearance of amyloid beta (key in the pathophysiology of Alzheimer's disease) occurs during sleep. Some electroencephalographic characteristics of sleep and wakefulness have been considered a hallmark of dementia. Owners of dogs with canine cognitive dysfunction syndrome (a canine analog to Alzheimer's disease) report that their dogs suffer from difficulty sleeping. The aim of this study was to quantify age-related changes in the sleep-wakefulness cycle macrostructure and electroencephalographic features in senior dogs and to correlate them with their cognitive performance.}, journal={FRONTIERS IN VETERINARY SCIENCE}, author={Mondino, Alejandra and Catanzariti, Magaly and Mateos, Diego Martin and Khan, Michael and Ludwig, Claire and Kis, Anna and Gruen, Margaret E. and Olby, Natasha J.}, year={2023}, month={Apr} }
 @article{mondino_khan_case_fefer_panek_gruen_olby_2023, title={Winning the race with aging: age-related changes in gait speed and its association with cognitive performance in dogs}, volume={10}, ISSN={["2297-1769"]}, DOI={10.3389/fvets.2023.1150590}, abstractNote={IntroductionIn humans, gait speed is a crucial component in geriatric evaluation since decreasing speed can be a harbinger of cognitive decline and dementia. Aging companion dogs can suffer from age-related mobility impairment, cognitive decline and dementia known as canine cognitive dysfunction syndrome. We hypothesized that there would be an association between gait speed and cognition in aging dogs.}, journal={FRONTIERS IN VETERINARY SCIENCE}, author={Mondino, Alejandra and Khan, Michael and Case, Beth and Fefer, Gilad and Panek, Wojciech K. and Gruen, Margaret E. and Olby, Natasha J.}, year={2023}, month={Jun} }
 @article{fefer_khan_panek_case_gruen_olby_2022, title={Relationship between hearing, cognitive function, and quality of life in aging companion dogs}, volume={8}, ISSN={["1939-1676"]}, url={https://doi.org/10.1111/jvim.16510}, DOI={10.1111/jvim.16510}, abstractNote={Abstract}, journal={JOURNAL OF VETERINARY INTERNAL MEDICINE}, author={Fefer, Gilad and Khan, Michael Z. and Panek, Wojciech K. and Case, Beth and Gruen, Margaret E. and Olby, Natasha J.}, year={2022}, month={Aug} }
 @article{fefer_panek_khan_singer_westermeyer_mowat_murdoch_case_olby_gruen_2022, title={Use of Cognitive Testing, Questionnaires, and Plasma Biomarkers to Quantify Cognitive Impairment in an Aging Pet Dog Population}, volume={87}, ISSN={["1875-8908"]}, DOI={10.3233/JAD-215562}, abstractNote={Background: Aging dogs may suffer from canine cognitive dysfunction syndrome (CCDS), a condition in which cognitive decline is associated with amyloid pathology and cortical atrophy. Presumptive diagnosis is made through physical examination, exclusion of systemic/metabolic conditions, and completion of screening questionnaires by owners. Objective: This study aimed to determine whether cognitive function could be quantified in aging pet dogs, and to correlate cognitive testing with validated questionnaires and plasma neurofilament light chain (pNfL) concentration. Methods: Thirty-nine dogs from fifteen breeds were recruited (9.3 to 15.3 years). Owners completed the Canine Dementia Scale (CADES) and Canine Cognitive Dysfunction Rating scale (CCDR). Executive control and social cues were tested, and pNfL was measured with single molecule array assay. Comparisons were made between cognitive testing scores, CADES, CCDR scores, and pNfL. Results: CADES scoring classified five dogs as severe CCDS, six as moderate, ten as mild, and eighteen as normal. CCDR identified seven dogs at risk of CCDS and thirty-two as normal. Cognitive testing was possible in the majority of dogs, although severely affected dogs were unable to learn tasks. CADES score correlated with sustained attention duration (r = –0.47, p = 0.002), inhibitory control (r = –0.51, p = 0.002), detour (r = –0.43, p = 0.001), and pNfL (r = 0.41, p = 0.025). Concentration of pNfL correlated with inhibitory control (r = –0.7, p≤0.001). The CCDR scale correlated with performance on inhibitory control (r = –0.46, p = 0.005). Conclusion: Our findings suggest that a multi-dimensional approach using a combination of questionnaires, specific cognitive tests, and pNfL concentration can be used to quantify cognitive decline in aging pet dogs.}, number={3}, journal={JOURNAL OF ALZHEIMERS DISEASE}, author={Fefer, Gilad and Panek, Wojciech K. and Khan, Michael Z. and Singer, Matthew and Westermeyer, Hans D. and Mowat, Freya M. and Murdoch, David M. and Case, Beth and Olby, Natasha J. and Gruen, Margaret E.}, year={2022}, pages={1367–1378} }