Nathan Charles Crook

Discovery and delivery strategies for engineered live biotherapeutic products

[Review of ]. TRENDS IN BIOTECHNOLOGY.

Inducible directed evolution of complex phenotypes in bacteria

Al'Abri, I. S., Haller, D. J., Li, Z., & Crook, N. (2022, February 12). NUCLEIC ACIDS RESEARCH, Vol. 2.

A Liquid Metal Mediated Metallic Coating for Antimicrobial and Antiviral Fabrics

Kwon, K. Y., Cheeseman, S., Frias-De-Diego, A., Hong, H., Yang, J., Jung, W., … Kim, T.-il. (2021, September 22). ADVANCED MATERIALS, Vol. 9.

Design and in situ biosynthesis of precision therapies against gastrointestinal pathogens

CURRENT OPINION IN PHYSIOLOGY, 10.

In Silico Identification and Experimental Validation of Peptide-Based Inhibitors Targeting Clostridium difficile Toxin A

Xiao, X., Sarma, S., Menegatti, S., Crook, N., Magness, S. T., & Hall, C. K. (2021, December 29). ACS CHEMICAL BIOLOGY, Vol. 17, pp. 118–128.

In Situ Biomanufacturing of Small Molecules in the Mammalian Gut by Probiotic Saccharomyces boulardii

ACS SYNTHETIC BIOLOGY, 10(5), 1039–1052.

What E. coli knows about your 1-year-old infant: Antibiotic use, lifestyle, birth mode, and siblings

Al'Abri, I. S., Durmusoglu, D., & Crook, N. (2021, June 9). CELL HOST & MICROBE, Vol. 6.

Establishing Probiotic Saccharomyces boulardii as a Model Organism for Synthesis and Delivery of Biomolecules

Durmusoglu, D., Al’Abri, I., Collins, S. P., Beisel, C., & Crook, N. (2020, January 23). (Vol. 1). Vol. 1.

Inducible Directed Evolution of Complex Phenotypes in Bacteria

Al’Abri, I. S., Haller, D. J., & Crook, N. (2020, October 31). (Vol. 10). Vol. 10.

Transcript Barcoding Illuminates the Expression Level of Synthetic Constructs in E. coli Nissle Residing in the Mammalian Gut

ACS SYNTHETIC BIOLOGY, 9(5), 1010–1021.

Adaptive Strategies of the Candidate Probiotic E. coli Nissle in the Mammalian Gut

CELL HOST & MICROBE, 25(4), 499-+.

Barriers to genome editing with CRISPR in bacteria

[Review of ]. JOURNAL OF INDUSTRIAL MICROBIOLOGY & BIOTECHNOLOGY, 46(9-10), 1327–1341.

Adaptive strategies of the candidate probiotic E. coli Nissle in the mammalian gut

Crook, N., Ferreiro, A., Gasparrini, A. J., Pesesky, M., Gibson, M. K., Wang, B., … Dantas, G. (2018, July 8). (Vol. 7). Vol. 7.

In vivo continuous evolution of genes and pathways in yeast

Nature Communications, 7(1).

Design of synthetic yeast promoters via tuning of nucleosome architecture

Nat Comms, 5.

Optimization of a Yeast RNA Interference System for Controlling Gene Expression and Enabling Rapid Metabolic Engineering

ACS Synth. Biol., 3(5), 307–313.

Model-based design of synthetic, biological systems

Chemical Engineering Science, 103, 2–11.

Classical Strain Improvement

Crook, N., & Alper, H. S. (2012, October). Engineering Complex Phenotypes in Industrial Strains, pp. 1–33.

Innovation at the intersection of synthetic and systems biology

Current Opinion in Biotechnology, 23(5), 712–717.

Linking Yeast Gcn5p Catalytic Function and Gene Regulation Using a Quantitative, Graded Dominant Mutant Approach

PLoS ONE, 7(4), e36193.

Structure-Guided Directed Evolution of Highly Selective P450-Based Magnetic Resonance Imaging Sensors for Dopamine and Serotonin

Journal of Molecular Biology, 422(2), 245–262.

Re-engineering multicloning sites for function and convenience

Nucleic Acids Research, 39(14), e92–e92.

Using Flux Balance Analysis to Guide Microbial Metabolic Engineering

Curran, K. A., Crook, N. C., & Alper, H. S. (2011, November). Microbial Metabolic Engineering, pp. 197–216.

Improved product-per-glucose yields in P450-dependent propane biotransformations using engineered Escherichia coli

Biotechnol. Bioeng., 108(3), 500–510.

Engineered Alkane-Hydroxylating Cytochrome P450BM3 Exhibiting Nativelike Catalytic Properties

Angew. Chem., 119(44), 8566–8570.

Engineered Alkane-Hydroxylating Cytochrome P450BM3 Exhibiting Nativelike Catalytic Properties

Angew. Chem. Int. Ed., 46(44), 8414–8418.