Works (33)

Updated: June 6th, 2023 05:01

2023 article

An integrated chemical engineering approach to understanding microplastics

Bang, R. S., Bergman, M., Li, T., Mukherjee, F., Alshehri, A. S., Abbott, N. L., … You, F. (2023, January 26). AICHE JOURNAL, Vol. 1.

By: R. Bang, M. Bergman, T. Li, F. Mukherjee*, A. Alshehri*, N. Abbott*, N. Crook, O. Velev, C. Hall, F. You*

author keywords: artificial intelligence; biochemical engineering; interfacial processes; microplastic; hermodynamics/statisticaL
Sources: Web Of Science, ORCID
Added: February 20, 2023

2023 review

Carotenoids and Their Health Benefits as Derived via Their Interactions with Gut Microbiota

[Review of ]. ADVANCES IN NUTRITION, 14(2), 238–255.

By: A. Eroglu, I. Al'Abri, R. Kopec, N. Crook & T. Bohn

author keywords: Carotenes; xanthophylls; digestion; carotenoid metabolites; gut bacteria; microbiome; mucosal layer; inflammation; oxidative stress; bactericidal effects; Bifidobacterium spp; Akkermansia spp
Sources: Web Of Science, ORCID
Added: April 11, 2023

2023 article

Design of 8-mer Peptides that BlockClostridioides difficileToxin A in Intestinal Cells

Sarma, S., Catella, C. M., Pedro, E. T. S., Xiao, X., Durmusoglu, D., Menegatti, S., … Hall, C. K. (2023, January 12).

By: S. Sarma n, C. Catella n, E. Pedro*, X. Xiao n, D. Durmusoglu n, S. Menegatti n, N. Crook, S. Magness*, C. Hall n

Source: ORCID
Added: January 13, 2023

2023 article

Engineering the Maize Root Microbiome: A Rapid MoClo Toolkit and Identification of Potential Bacterial Chassis for studying Plant-Microbe Interactions

Schaik, J. V., Li, Z., Cheadle, J. B., & Crook, N. C. (2023, June 5).

By: J. Schaik, Z. Li, J. Cheadle & N. Crook

Source: ORCID
Added: June 6, 2023

2022 review

Discovery and delivery strategies for engineered live biotherapeutic products

[Review of ]. TRENDS IN BIOTECHNOLOGY, 40(3), 354–369.

By: M. Heavey, D. Durmusoglu, N. Crook & A. Anselmo

Sources: Web Of Science, ORCID
Added: March 7, 2022

2022 journal article

Engineered cell differentiation and sexual reproduction in probiotic and mating yeasts

NATURE COMMUNICATIONS, 13(1).

By: E. Jensen*, M. Deichmann, X. Ma, R. Vilandt, G. Schiesaro, M. Rojek, B. Lengger, L. Eliasson ...

Sources: Web Of Science, ORCID
Added: October 31, 2022

2022 journal article

Functional mining of novel terpene synthases from metagenomes

BIOTECHNOLOGY FOR BIOFUELS AND BIOPRODUCTS, 15(1).

By: S. Kwak*, N. Crook, A. Yoneda, N. Ahn, J. Ning, J. Cheng, G. Dantas

author keywords: Functional metagenomics; Terpene synthase; Prenyl pyrophosphate; beta-Farnesene
Sources: Web Of Science, ORCID
Added: October 24, 2022

2022 article

Improving Therapeutic Protein Secretion in the Probiotic YeastSaccharomyces boulardiiusing a Multifactorial Engineering Approach

Durmusoglu, D., Al’Abri, I., Williams, T. I., Collins, L. B., Martínez, J. L., & Crook, N. (2022, December 31).

By: D. Durmusoglu n, I. Al’Abri n, T. Williams, L. Collins n, J. Martínez* & N. Crook

Source: ORCID
Added: January 1, 2023

2022 article

Inducible directed evolution of complex phenotypes in bacteria

Al'Abri, I. S., Haller, D. J., Li, Z., & Crook, N. (2022, February 12). NUCLEIC ACIDS RESEARCH, Vol. 2.

By: I. Al'Abri, D. Haller, Z. Li & N. Crook

Sources: ORCID, Web Of Science
Added: February 13, 2022

2021 article

A Liquid Metal Mediated Metallic Coating for Antimicrobial and Antiviral Fabrics

Kwon, K. Y., Cheeseman, S., Frias-De-Diego, A., Hong, H., Yang, J., Jung, W., … Kim, T.-il. (2021, September 22). ADVANCED MATERIALS, Vol. 9.

By: K. Kwon n, S. Cheeseman*, A. Frias-De-Diego n, H. Hong*, J. Yang, W. Jung*, H. Yin*, B. Murdoch* ...

author keywords: antimicrobial; antiviral; galvanic replacement; liquid metal fabric coating
Sources: Web Of Science, ORCID
Added: September 28, 2021

2021 journal article

Design and in situ biosynthesis of precision therapies against gastrointestinal pathogens

CURRENT OPINION IN PHYSIOLOGY, 23.

Sources: Web Of Science, ORCID
Added: October 26, 2021

2021 article

In Silico Identification and Experimental Validation of Peptide-Based Inhibitors Targeting Clostridium difficile Toxin A

Xiao, X., Sarma, S., Menegatti, S., Crook, N., Magness, S. T., & Hall, C. K. (2021, December 29). ACS CHEMICAL BIOLOGY, Vol. 17.

By: X. Xiao, S. Sarma, S. Menegatti, N. Crook, S. Magness & C. Hall

Sources: ORCID, Web Of Science
Added: December 30, 2021

2021 journal article

In Situ Biomanufacturing of Small Molecules in the Mammalian Gut by Probiotic Saccharomyces boulardii

ACS SYNTHETIC BIOLOGY, 10(5), 1039–1052.

author keywords: Saccharomyces boulardii; probiotic engineering; metabolic engineering; colonization profile; in situ production; beta-carotene
Sources: ORCID, Web Of Science
Added: May 6, 2021

2021 article

What E. coli knows about your 1-year-old infant: Antibiotic use, lifestyle, birth mode, and siblings

Al'Abri, I. S., Durmusoglu, D., & Crook, N. (2021, June 9). CELL HOST & MICROBE, Vol. 29, pp. 854–855.

By: I. Al'Abri, D. Durmusoglu & N. Crook

Sources: Web Of Science, ORCID
Added: June 28, 2021

2020 article

Establishing Probiotic Saccharomyces boulardii as a Model Organism for Synthesis and Delivery of Biomolecules

Durmusoglu, D., Al’Abri, I., Collins, S. P., Beisel, C., & Crook, N. (2020, January 23). (Vol. 1). Vol. 1.

By: D. Durmusoglu n, I. Al’Abri n, S. Collins n, C. Beisel n & N. Crook

Source: ORCID
Added: May 6, 2021

2020 article

Inducible Directed Evolution of Complex Phenotypes in Bacteria

Al’Abri, I. S., Haller, D. J., & Crook, N. (2020, October 31). (Vol. 10). Vol. 10.

By: I. Al’Abri n, D. Haller n & N. Crook

Source: ORCID
Added: May 6, 2021

2020 journal article

Transcript Barcoding Illuminates the Expression Level of Synthetic Constructs in E. coli Nissle Residing in the Mammalian Gut

ACS SYNTHETIC BIOLOGY, 9(5), 1010–1021.

By: N. Crook, A. Ferreiro*, Z. Condiotte* & G. Dantas*

Sources: Web Of Science, ORCID
Added: June 8, 2020

2019 journal article

Adaptive Strategies of the Candidate Probiotic E. coli Nissle in the Mammalian Gut

CELL HOST & MICROBE, 25(4), 499-+.

By: N. Crook, A. Ferreiro*, A. Gasparrini*, M. Pesesky*, M. Gibson*, B. Wang*, X. Sun*, Z. Condiotte* ...

Sources: Web Of Science, ORCID
Added: April 29, 2019

2019 review

Barriers to genome editing with CRISPR in bacteria

[Review of ]. JOURNAL OF INDUSTRIAL MICROBIOLOGY & BIOTECHNOLOGY, 46(9-10), 1327–1341.

By: J. Vento, N. Crook & C. Beisel

author keywords: Bacteria; Nuclease; Genome editing; CRISPR; Recombineering
Sources: Web Of Science, ORCID
Added: October 28, 2019

2018 article

Adaptive strategies of the candidate probiotic E. coli Nissle in the mammalian gut

Crook, N., Ferreiro, A., Gasparrini, A. J., Pesesky, M., Gibson, M. K., Wang, B., … Dantas, G. (2018, July 8). (Vol. 7). Vol. 7.

By: N. Crook, A. Ferreiro*, A. Gasparrini*, M. Pesesky*, M. Gibson*, B. Wang*, X. Sun*, Z. Condiotte* ...

Source: ORCID
Added: May 6, 2021

2016 journal article

In vivo continuous evolution of genes and pathways in yeast

Nature Communications.

By: N. Crook, J. Abatemarco*, J. Sun*, J. Wagner*, A. Schmitz* & H. Alper

Source: ORCID
Added: May 6, 2021

2014 journal article

Design of synthetic yeast promoters via tuning of nucleosome architecture

Nat Comms, 5.

By: K. Curran*, N. Crook, A. Karim*, A. Gupta*, A. Wagman* & H. Alper

Source: ORCID
Added: May 6, 2021

2014 journal article

Optimization of a Yeast RNA Interference System for Controlling Gene Expression and Enabling Rapid Metabolic Engineering

ACS Synth. Biol., 3(5), 307–313.

By: N. Crook, A. Schmitz* & H. Alper

author keywords: yeast; RNA interference; metabolic engineering; itaconic acid; gene knockdown
Source: ORCID
Added: May 6, 2021

2013 journal article

Model-based design of synthetic, biological systems

Chemical Engineering Science, 103, 2–11.

By: N. Crook & H. Alper

author keywords: Cellular biology and engineering; Mathematical modeling; Biological and biomolecular engineering; Metabolism; Molecular biology; Synthetic biology
Source: ORCID
Added: May 6, 2021

2012 article

Classical Strain Improvement

Crook, N., & Alper, H. S. (2012, October). Engineering Complex Phenotypes in Industrial Strains, pp. 1–33.

By: N. Crook & H. Alper

Source: ORCID
Added: May 6, 2021

2012 journal article

Innovation at the intersection of synthetic and systems biology

Current Opinion in Biotechnology, 23(5), 712–717.

By: A. Lanza*, N. Crook & H. Alper

Source: ORCID
Added: May 6, 2021

2012 journal article

Linking Yeast Gcn5p Catalytic Function and Gene Regulation Using a Quantitative, Graded Dominant Mutant Approach

PLoS ONE, 7(4), e36193.

By: A. Lanza*, J. Blazeck*, N. Crook & H. Alper

Ed(s): C. Chan

Source: ORCID
Added: May 6, 2021

2012 journal article

Structure-Guided Directed Evolution of Highly Selective P450-Based Magnetic Resonance Imaging Sensors for Dopamine and Serotonin

Journal of Molecular Biology, 422(2), 245–262.

By: E. Brustad*, V. Lelyveld*, C. Snow*, N. Crook, S. Jung*, F. Martinez*, T. Scholl*, A. Jasanoff*, F. Arnold*

author keywords: directed evolution; cytochrome P450; MRI contrast agents; neurotransmitter; biosensors
Source: ORCID
Added: May 6, 2021

2011 journal article

Re-engineering multicloning sites for function and convenience

Nucleic Acids Research, 39(14), e92–e92.

By: N. Crook, E. Freeman & H. Alper

Source: ORCID
Added: May 6, 2021

2011 article

Using Flux Balance Analysis to Guide Microbial Metabolic Engineering

Curran, K. A., Crook, N. C., & Alper, H. S. (2011, November). Microbial Metabolic Engineering, pp. 197–216.

By: K. Curran*, N. Crook & H. Alper

author keywords: Flux balance analysis; MOMA; Genomic-scale metabolic model; Metabolic engineering; Strain engineering
Source: ORCID
Added: May 6, 2021

2010 journal article

Improved product-per-glucose yields in P450-dependent propane biotransformations using engineered Escherichia coli

Biotechnol. Bioeng., 108(3), 500–510.

By: R. Fasan*, N. Crook, M. Peters*, P. Meinhold*, T. Buelter*, M. Landwehr*, P. Cirino, F. Arnold*

author keywords: cytochrome P450 monooxygenase; alkane oxidation; BM-3; whole-cell biotransformations; protein engineering; Escherichia coli
Source: ORCID
Added: May 6, 2021

2007 journal article

Engineered Alkane-Hydroxylating Cytochrome P450BM3 Exhibiting Nativelike Catalytic Properties

Angew. Chem., 119(44), 8566–8570.

By: R. Fasan*, M. Chen*, N. Crook & F. Arnold*

Source: ORCID
Added: May 6, 2021

2007 journal article

Engineered Alkane-Hydroxylating Cytochrome P450BM3 Exhibiting Nativelike Catalytic Properties

Angew. Chem. Int. Ed., 46(44), 8414–8418.

By: R. Fasan*, M. Chen, N. Crook & F. Arnold

author keywords: alkane oxidation; biotransformations; cytochrome P450; directed evolution; protein engineering
Source: ORCID
Added: May 6, 2021

Employment

Updated: December 30th, 2022 21:48

2018 - present

North Carolina State University Raleigh, North Carolina, US
Assistant Professor Chemical and Biomolecular Engineering

2014 - 2017

Washington University in St Louis Saint Louis, MO, US
Postdoctoral Research Associate Pathology

Education

Updated: September 17th, 2014 15:12

2009 - 2014

University of Texas at Austin Austin, TX, US
Doctor of Philosophy Chemical Engineering

2005 - 2009

California Institute of Technology Pasadena, CA, US
Bachelor of Science Chemical Engineering