Works (20)
Updated: August 15th, 2023 09:15
2017 journal article
A Nonparametric survival function estimator via censored kernel quantile regressions
Statistica Sinica, 27(1), 457–478.
Source: NC State University Libraries
Added: August 6, 2018
2017 journal article
Deciphering the routes of invasion of Drosophila suzukii by means of ABC random forest
Molecular Biology and Evolution, 34(4), 980–996.
Source: NC State University Libraries
Added: August 6, 2018
2017 review
Variation in Recombination Rate: Adaptive or Not?
[Review of ]. TRENDS IN GENETICS, 33(5), 364–374.
MeSH headings : Animals; Evolution, Molecular; Genetic Variation; Humans; Meiosis / genetics; Recombination, Genetic
TL;DR:
The apparent similarity of the variance in recombination rate among individuals between distantly related species suggests that the relative costs and benefits of recombination that establish the upper and lower bounds may be similar across species.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
15. Life on Land
(OpenAlex)
Source: Web Of Science
Added: August 6, 2018
2016 personal communication
Bias-Variance Tradeoffs in Recombination Rate Estimation
Stone, E. A., & Singh, N. D. (2016, February).
MeSH headings : Alleles; Animals; Bias; Drosophila melanogaster / genetics; Gene Frequency; Genetic Variation; Models, Genetic; Models, Statistical; Recombination, Genetic
TL;DR:
To extract the signal of recombination in high-throughput sequence data, a nonparametric smoothing procedure was adopted, reducing variance at the cost of biasing individual recombination rates.
(via Semantic Scholar)
open access via www.genetics.org (publisher PDF)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Source: Web Of Science
Added: August 6, 2018
2016 journal article
Expansion of GA Dinucleotide Repeats Increases the Density of CLAMP Binding Sites on the X-Chromosome to Promote Drosophila Dosage Compensation
PLOS GENETICS, 12(7).
MeSH headings : Amino Acid Motifs; Animals; Binding Sites; Biological Evolution; DNA / chemistry; DNA-Binding Proteins / genetics; Dinucleotide Repeats; Dosage Compensation, Genetic; Drosophila Proteins / genetics; Drosophila melanogaster / genetics; Female; Gene Dosage; Genes, X-Linked; Genetic Linkage; Genome, Insect; Male; Oligonucleotide Array Sequence Analysis; Sequence Analysis, DNA; X Chromosome / genetics
TL;DR:
It is revealed that expansion of GA-dinucleotide repeats likely accumulated on the X-chromosome over evolutionary time to increase the density of CLAMP binding sites, thereby driving the evolution of dosage compensation.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Source: Web Of Science
Added: August 6, 2018
2016 journal article
Genetic Background, Maternal Age, and Interaction Effects Mediate Rates of Crossing Over in Drosophila melanogaster Females
G3-GENES GENOMES GENETICS, 6(5), 1409–1416.
author keywords: meiosis; recombination; aging
MeSH headings : Animals; Crossing Over, Genetic; Drosophila melanogaster / genetics; Female; Genetic Background; Genetic Loci; Genome, Insect; Genomics / methods; Male; Meiosis / genetics; Models, Genetic; Recombination, Genetic
TL;DR:
The hypothesis that maternal age influences rates of crossing over in a genotypic-specific manner is tested and a new role of genotype by maternal age interactions in mediating recombination rate is revealed.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Source: Web Of Science
Added: August 6, 2018
2015 journal article
Fruit flies diversify their offspring in response to parasite infection
SCIENCE, 349(6249), 747–750.
MeSH headings : Animals; Biological Evolution; Drosophila melanogaster / genetics; Drosophila melanogaster / growth & development; Drosophila melanogaster / parasitology; Female; Genetic Fitness; Genetic Variation; Larva; Male; Mutation; Parasitic Diseases / genetics; Recombination, Genetic; Reproduction / genetics
TL;DR:
It is shown that Drosophila melanogaster plastically increases the production of recombinant offspring after infection, which is consistent across genetic backgrounds, developmental stages, and parasite types but is not induced after sterile wounding.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
13. Climate Action
(Web of Science)
15. Life on Land
(Web of Science)
Source: Web Of Science
Added: August 6, 2018
2015 journal article
Increased exposure to acute thermal stress is associated with a non-linear increase in recombination frequency and an independent linear decrease in fitness in Drosophila
BMC EVOLUTIONARY BIOLOGY, 15.
MeSH headings : Animals; Biological Evolution; Drosophila melanogaster / cytology; Drosophila melanogaster / genetics; Drosophila melanogaster / physiology; Heat-Shock Response; Meiosis; Recombination, Genetic
TL;DR:
It is found that increased exposure to heat shock conditions is associated with a non-linear increase in meiotic recombination frequency, and an independent effect of heat shock on organismal fitness, with fitness decreasing with increased duration of thermal stress.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
13. Climate Action
(Web of Science)
15. Life on Land
(Web of Science)
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018
2015 journal article
No Evidence that Infection Alters Global Recombination Rate in House Mice
PLoS One, 10(11).
MeSH headings : Animals; Borrelia Infections / genetics; Borrelia Infections / microbiology; Borrelia burgdorferi / physiology; Crossing Over, Genetic; Female; Genetic Variation; Male; Mice; Mice, Inbred C57BL; Testis / metabolism
TL;DR:
The findings suggest that recombination rates in house mice may be resilient to at least some forms of infection stress, and motivates future experiments with alternative house mouse pathogens to evaluate the generality of this conclusion.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
13. Climate Action
(Web of Science)
15. Life on Land
(Web of Science; OpenAlex)
Source: Web Of Science
Added: August 6, 2018
2015 journal article
Tetracycline-exposed Drosophila melanogaster males produce fewer offspring but a relative excess of sons
ECOLOGY AND EVOLUTION, 5(15), 3130–3139.
author keywords: Drosophila; fitness; sex ratio; tetracycline; Wolbachia
TL;DR:
The results indicate that tetracycline-treated males produce a relative excess of sons and the number of progeny produced by treated males but not treated females, and implicate the antibiotic itself as mediating these changes.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Source: Web Of Science
Added: August 6, 2018
2014 journal article
DO MALES MATTER? TESTING THE EFFECTS OF MALE GENETIC BACKGROUND ON FEMALE MEIOTIC CROSSOVER RATES IN DROSOPHILA MELANOGASTER
EVOLUTION, 68(9), 2718–2726.
author keywords: Drosophila; meiosis; recombination
MeSH headings : Animals; Crossing Over, Genetic; Drosophila melanogaster / genetics; Female; Male; Meiosis; Recombination, Genetic; X Chromosome
TL;DR:
The results indicate that although female genetic background significantly affects female meiotic crossover rates in Drosophila, male genetic background and the interaction of female and male genetic backgrounds have no significant effect, suggesting that male‐mediated effects are unlikely to contribute greatly to variation in recombination rates in natural populations of Drosophile.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Source: Web Of Science
Added: August 6, 2018
2014 journal article
Drosophila suzukii: The Genetic Footprint of a Recent, Worldwide Invasion
MOLECULAR BIOLOGY AND EVOLUTION, 31(12), 3148–3163.
author keywords: Drosophila suzukii; population genetics; invasion; pest
MeSH headings : Animals; Bayes Theorem; Drosophila / genetics; Genes, Insect; Genetic Variation; Haplotypes; Introduced Species; Male; Microsatellite Repeats; Models, Genetic; Spain; United States
TL;DR:
The results indicate high levels of nucleotide diversity in this invasive fruit fly species and suggest that the recent invasions of Europe and the continental United States are independent demographic events, which highlights the importance of integrating population structure into demographic models.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
13. Climate Action
(Web of Science)
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018
2014 journal article
Positive and Purifying Selection on the Drosophila Y Chromosome
MOLECULAR BIOLOGY AND EVOLUTION, 31(10), 2612–2623.
author keywords: Y chromosome; Drosophila; positive selection; purifying selection
MeSH headings : Animals; Drosophila / classification; Drosophila / genetics; Evolution, Molecular; Female; Male; Models, Genetic; Mutation Rate; Phylogeny; Selection, Genetic; Sequence Deletion; Y Chromosome / genetics
TL;DR:
The results confirm the expectation that the efficacy of natural selection at weakly selected sites is reduced on the Y chromosome and highlight the variable nature of the mode and impact ofnatural selection on the Drosophila Y chromosome.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Source: Web Of Science
Added: August 6, 2018
2013 journal article
Fine-scale heterogeneity in crossover rate in the garnet-scalloped region of the Drosophila melanogaster X chromosome
Genetics, 194(2), 375–112.
Source: NC State University Libraries
Added: August 6, 2018
2013 journal article
Population Genomic Analysis Reveals No Evidence for GC-Biased Gene Conversion in Drosophila melanogaster
MOLECULAR BIOLOGY AND EVOLUTION, 31(2), 425–433.
author keywords: GC-biased gene conversion; Drosophila melanogaster; whole genome; polymorphism and divergence data
MeSH headings : Alleles; Animals; Chromosomes, Insect; Cytosine / metabolism; Drosophila melanogaster / genetics; Evolution, Molecular; Gene Conversion; Genome, Insect; Genomics; Guanine / metabolism; Mutation Rate; Phylogeny; Polymorphism, Genetic
TL;DR:
It is suggested that this process of gene conversion in Drosophila melanogaster is unlikely to significantly contribute to patterns of polymorphism and divergence in this system, and the results provide no support for GC-biased gene conversion.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Source: Web Of Science
Added: August 6, 2018
2012 article
Classical Genetics Meets Next-Generation Sequencing: Uncovering a Genome-Wide Recombination Drosophila melanogaster
Singh, N. D. (2012, October). PLOS GENETICS, Vol. 8.
MeSH headings : Animals; Chromosome Mapping; Drosophila melanogaster / genetics; Genome; High-Throughput Nucleotide Sequencing; Recombination, Genetic
TL;DR:
The power of classical genetics with next-generation sequencing is combined to provide for the first time a high-resolution recombination map of the D. melanogaster genome, showing that although crossover and nonc crossover rates are both significantly variable genome-wide, rates of crossing-over are ten times more variable than noncrossover rates.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Source: Web Of Science
Added: August 6, 2018
2012 journal article
Impact of Genetic Architecture on the Relative Rates of X versus Autosomal Adaptive Substitution
MOLECULAR BIOLOGY AND EVOLUTION, 29(8), 1933–1942.
author keywords: dominance; epistasis; genetics of adaptation; soft sweeps; molecular evolution
MeSH headings : Adaptation, Physiological / genetics; Animals; Chromosomes, Human, X / genetics; Evolution, Molecular; Genes / genetics; Humans; Models, Genetic; Mutation / genetics; Phylogeny; Population Density; X Chromosome / genetics
TL;DR:
The new theory unites the previously separate analysis of adaptation using new mutations versus standing genetic variation and makes several useful predictions about the interaction between genetic architecture, evolutionary genetic constraints, and effective population size in determining the ratio of adaptive substitution between autosomal and X-linked genes.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Source: Web Of Science
Added: August 6, 2018
2012 journal article
Inferences of Demography and Selection in an African Population of Drosophila melanogaster
GENETICS, 193(1), 215–228.
MeSH headings : Adaptation, Physiological; Africa; Animals; Demography; Drosophila melanogaster / genetics; Genetics, Population; Genome; High-Throughput Nucleotide Sequencing; Models, Genetic; Polymorphism, Genetic; Selection, Genetic
TL;DR:
Demographic modeling of this ancestral population of Drosophila melanogaster reveals a strong signature of a population bottleneck followed by population expansion, which has significant implications for future demographic modeling of derived populations of this species.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Source: Web Of Science
Added: August 6, 2018
2011 article
On the scent of pleiotropy
Singh, N. D., & Shaw, K. L. (2012, January 3). PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, Vol. 109, pp. 5–6.
MeSH headings : Animals; Drosophila Proteins / genetics; Drosophila melanogaster / enzymology; Drosophila melanogaster / genetics; Fatty Acid Desaturases / genetics; Female; Gene Expression Regulation, Enzymologic; Male; Nervous System / enzymology; Perception / physiology; Sex Attractants / metabolism
TL;DR:
The work presented in PNAS by Bousquet et al. (4) builds the best case to date for genetic coupling between signaler and receiver traits in sexual communication.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
15. Life on Land
(Web of Science)
Source: Web Of Science
Added: August 6, 2018
journal article
The genetic architecture of natural variation in recombination rate in Drosophila melanogaster
Hunter, C. M., Huang, W., Mackay, T. F. C., & Singh, N. D. PLoS Genetics, 12(4).
Source: NC State University Libraries
Added: August 6, 2018
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