Works (16)

Updated: April 3rd, 2024 18:10

2022 journal article

Early life adversity drives sex-specific anhedonia and meningeal immune gene expression through mast cell activation

Brain, Behavior, and Immunity, 103, 73–84.

By: N. Duque-Wilckens*, R. Teis*, E. Sarno*, F. Stoelting*, S. Khalid*, Z. Dairi*, A. Douma*, N. Maradiaga* ...

TL;DR: The results indicate that ELA induces long-term meningeal immune gene changes and heightened sensitivity to adult stress-induced behavioral and meningealing immune responses and that these effects could mediated via mast cells. (via Semantic Scholar)
Source: ORCID
Added: January 28, 2024

2022 journal article

Impaired KDM2B-mediated PRC1 recruitment to chromatin causes defective neural stem cell self-renewal and ASD/ID-like behaviors

IScience, 25(2), 103742.

TL;DR: A critical role of KDM2B in normal brain development is revealed, a causality between the Kdm2b mutation and ASD/ID-like phenotypes in mice are revealed, and potential molecular mechanisms linking the function of K DM2B-PRC1 in transcriptional regulation to the 12q24.31 microdeletion-associated ASD/ ID are proposed. (via Semantic Scholar)
Source: ORCID
Added: January 28, 2024

2022 journal article

Oxytocin release in stressful times

Psychoneuroendocrinology, 140, 105709.

By: N. Duque-Wilckens* & B. Trainor*

Source: ORCID
Added: January 28, 2024

2021 journal article

Convergent neuroendocrine mechanisms of social buffering and stress contagion

Hormones and Behavior, 129, 104933.

By: N. Peen*, N. Duque-Wilckens* & B. Trainor*

TL;DR: The extent to which the neuropeptides corticotropin releasing hormone and oxytocin are involved in contagion and stress buffering is considered and the importance that frontal cortical areas such as the anterior cingulate cortex and infralimbic cortex play is assessed. (via Semantic Scholar)
Source: ORCID
Added: January 28, 2024

2021 journal article

Enriched laboratory housing increases sensitivity to social stress in female California mice (Peromyscus californicus)

Applied Animal Behaviour Science, 241, 105381.

By: V. Minie*, R. Petric*, S. Ramos-Maciel*, E. Wright*, B. Trainor* & N. Duque-Wilckens*

TL;DR: Assessing how different housing systems can affect California mouse behavior both in the home cage as well as the open field and social interaction tests before and after social defeat stress suggests that increasing social and environmental complexity affects home cage behaviors in male and female California mice without interfering with, but rather increasing the magnitude of, the effects of defeat stress on theopen field andsocial interaction tests. (via Semantic Scholar)
Source: ORCID
Added: January 28, 2024

2021 journal article

Loss of histone methyltransferase ASH1L in the developing mouse brain causes autistic-like behaviors

Communications Biology, 4(1).

TL;DR: It is shown loss of ASH1L in the developing mouse brain is sufficient to cause multiple developmental defects, core autistic-like behaviors, and impaired cognitive memory, and potential molecular mechanisms linking Ash1L mutations to brain functional abnormalities are established. (via Semantic Scholar)
Source: ORCID
Added: January 28, 2024

2020 journal article

Androgen-Dependent Excitability of Mouse Ventral Hippocampal Afferents to Nucleus Accumbens Underlies Sex-Specific Susceptibility to Stress

Biological Psychiatry, 87(6), 492–501.

TL;DR: A circuit-specific sex difference in vHPC-NAc neurons that is dependent on testosterone and causes susceptibility to stress in female mice is demonstrated, providing a substantive mechanism linking gonadal hormones to cellular excitability and anhedonia-a key feature in depressive states. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (OpenAlex)
Source: ORCID
Added: January 28, 2024

2020 journal article

Extrahypothalamic oxytocin neurons drive stress-induced social vigilance and avoidance

Proceedings of the National Academy of Sciences, 117(42), 26406–26413.

By: N. Duque-Wilckens*, L. Torres*, S. Yokoyama*, V. Minie*, A. Tran*, S. Petkova*, R. Hao*, S. Ramos-Maciel* ...

UN Sustainable Development Goal Categories
10. Reduced Inequalities (OpenAlex)
Source: ORCID
Added: January 28, 2024

2020 journal article

Histamine-dependent interactions between mast cells, glia, and neurons are altered following early-life adversity in mice and humans

American Journal of Physiology-Gastrointestinal and Liver Physiology, 319(6), G655–G668.

By: J. McClain*, E. Mazzotta*, N. Maradiaga*, N. Duque-Wilckens*, I. Grants*, A. Robison*, F. Christofi*, A. Moeser*, B. Gulbransen*

TL;DR: Early life stress alters interactions between enteric glia and mast cells that are mediated by histamine, and this mechanism could contribute to enteric neuroplasticity driven by early life adversity. (via Semantic Scholar)
Source: ORCID
Added: January 28, 2024

2020 journal article

Social approach and social vigilance are differentially regulated by oxytocin receptors in the nucleus accumbens

Neuropsychopharmacology, 45(9), 1423–1430.

By: A. Williams*, N. Duque-Wilckens*, S. Ramos-Maciel*, K. Campi*, S. Bhela*, C. Xu*, K. Jackson*, B. Chini*, P. Pesavento*, B. Trainor*

TL;DR: It is suggested that OTR in the NAc differentially modulate social approach and social vigilance, primarily through an OTR-Gq mechanism. (via Semantic Scholar)
Source: ORCID
Added: January 28, 2024

2019 journal article

Complementary Neural Circuits for Divergent Effects of Oxytocin: Social Approach Versus Social Anxiety

Biological Psychiatry, 85(10), 792–801.

By: M. Steinman*, N. Duque-Wilckens* & B. Trainor*

TL;DR: Evidence for neural circuits mediating the effects of OT in appetitive and aversive social contexts is reviewed and it is proposed that distinct but potentially overlapping circuits mediate OT-dependent social approach or social avoidance. (via Semantic Scholar)
UN Sustainable Development Goal Categories
10. Reduced Inequalities (OpenAlex)
Source: ORCID
Added: January 28, 2024

2019 journal article

Histone deacetylase inhibitor treatment promotes spontaneous caregiving behaviour in non‐aggressive virgin male mice

Journal of Neuroendocrinology, 31(9).

TL;DR: Results obtained indicate that systemic HDACi treatment induces spontaneous caregiving behaviour in non‐aggressive male mice and alters the pattern of pup‐induced IEG expression across a fear/defensive neural circuit. (via Semantic Scholar)
Source: ORCID
Added: January 28, 2024

2019 journal article

Impaired approach to novelty and striatal alterations in the oxytocin receptor deficient mouse model of autism

Hormones and Behavior, 114, 104543.

By: M. Leonzino*, L. Ponzoni*, D. Braida*, V. Gigliucci*, M. Busnelli*, I. Ceresini*, N. Duque-Wilckens*, K. Nishimori* ...

TL;DR: The data indicate a specific reshaping of dorsolateral striatal spines in Oxtr-/- mice after exposure to a novel environment, which might subtend their altered approach to novelty, and support previous work pointing at this structure as an important substrate for autistic behaviors. (via Semantic Scholar)
Source: ORCID
Added: January 28, 2024

2018 journal article

Oxytocin Receptors in the Anteromedial Bed Nucleus of the Stria Terminalis Promote Stress-Induced Social Avoidance in Female California Mice

Biological Psychiatry, 83(3), 203–213.

By: N. Duque-Wilckens*, M. Steinman*, M. Busnelli*, B. Chini*, S. Yokoyama*, M. Pham*, S. Laredo*, R. Hao* ...

TL;DR: The results suggest that OTR activation in anteromedial BNST induces a vigilance response in which individuals avoid, yet attend to, unfamiliar social contexts, and may have unappreciated therapeutic potential for stress-induced psychiatric disorders. (via Semantic Scholar)
Source: ORCID
Added: January 28, 2024

2016 journal article

Inhibition of vasopressin V1a receptors in the medioventral bed nucleus of the stria terminalis has sex- and context-specific anxiogenic effects

Neuropharmacology, 110, 59–68.

By: N. Duque-Wilckens*, M. Steinman*, S. Laredo*, R. Hao*, A. Perkeybile*, K. Bales*, B. Trainor*

TL;DR: It is suggested that males have more overlap in neural circuits modulating anxiety in social and nonsocial contexts than females, and that in females, prosocial and anxiolytic effects of V1aR appear to be mediated independently by receptors in the BNSTmv and NAc shell, respectively. (via Semantic Scholar)
Source: ORCID
Added: January 28, 2024

2016 journal article

Sex-Specific Effects of Stress on Oxytocin Neurons Correspond With Responses to Intranasal Oxytocin

Biological Psychiatry, 80(5), 406–414.

By: M. Steinman*, N. Duque-Wilckens*, G. Greenberg*, R. Hao*, K. Campi*, S. Laredo*, A. Laman-Maharg*, C. Manning* ...

TL;DR: Social defeat induces long-lasting increases in OT production and OT/c-fos cells in the medioventral bed nucleus of the stria terminalis of female mice but not male mice, suggesting changes in OT-sensitive networks contribute to sex differences in behavioral responses to stress. (via Semantic Scholar)
Source: ORCID
Added: January 28, 2024

Employment

Updated: April 6th, 2023 10:11

2023 - present

North Carolina State University Raleigh, North Carolina, US
Assistant Professor Department of Biological Sciences

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