Works (38)

2020 journal article

Chytrid fungi.

Current Biology : CB, 5.

By: E. Medina & N. Buchler

Source: ORCID
Added: May 25, 2020

2020 journal article

Genetic transformation of Spizellomyces punctatus, a resource for studying chytrid biology and evolutionary cell biology

ELife.

By: E. Medina, K. Robinson, K. Bellingham-Johnstun, G. Ianiri, C. Laplante, L. Fritz-Laylin, N. Buchler

Source: ORCID
Added: May 12, 2020

2019 journal article

Enhancer Histone Acetylation Modulates Transcriptional Bursting Dynamics of Neuronal Activity-Inducible Genes

CELL REPORTS, 26(5), 1174-.

By: L. Chen, Y. Lin, D. Gallegos, M. Hazlett, M. Gomez-Schiavon, M. Yang, B. Kalmeta, A. Zhou ...

Sources: NC State University Libraries, ORCID
Added: February 18, 2019

2019 journal article

Epigenetic switching as a strategy for quick adaptation while attenuating biochemical noise

PLOS COMPUTATIONAL BIOLOGY, 15(10).

By: M. Gomez-Schiavon & N. Buchler

Sources: Web Of Science, ORCID
Added: December 30, 2019

2019 review

Evolutionary innovation, fungal cell biology, and the lateral gene transfer of a viral KilA-N domain

[Review of ]. CURRENT OPINION IN GENETICS & DEVELOPMENT, 58-59, 103–110.

By: E. Medina, E. Walsh & N. Buchler

Sources: Web Of Science, ORCID
Added: December 16, 2019

2019 journal article

Exact and efficient hybrid Monte Carlo algorithm for accelerated Bayesian inference of gene expression models from snapshots of single-cell transcripts

The Journal of Chemical Physics.

By: Y. Lin & N. Buchler

Source: ORCID
Added: July 10, 2019

2019 journal article

Recognition of Histone Crotonylation by Taf14 Links Metabolic State to Gene Expression

MOLECULAR CELL, 76(6), 909-+.

By: G. Gowans, J. Bridgers, J. Zhang, R. Dronamraju, A. Burnetti, D. King, A. Thiengmany, S. Shinsky ...

Sources: ORCID, Web Of Science
Added: January 6, 2020

2018 journal article

Daily humidity oscillation regulates the circadian clock to influence plant physiology

NATURE COMMUNICATIONS, 9.

By: M. Mwimba, S. Karapetyan, L. Liu, J. Marques, E. McGinnis, N. Buchler, X. Dong

Sources: NC State University Libraries, ORCID
Added: October 29, 2018

2018 journal article

Efficient analysis of stochastic gene dynamics in the non-adiabatic regime using piecewise deterministic Markov processes

Journal of The Royal Society Interface, 15(138), 20170804.

By: Y. Lin & N. Buchler

Source: ORCID
Added: February 11, 2019

2017 journal article

BayFish: Bayesian inference of transcription dynamics from population snapshots of single-molecule RNA FISH in single cells

Genome Biology, 18(1).

By: M. Gómez-Schiavon, L. Chen, A. West & N. Buchler

Source: ORCID
Added: February 11, 2019

2017 journal article

Conservation and divergence of C-terminal domain structure in the retinoblastoma protein family

Proceedings of the National Academy of Sciences, 114(19), 4942–4947.

By: T. Liban, E. Medina, S. Tripathi, S. Sengupta, R. Henry, N. Buchler, S. Rubin

Source: ORCID
Added: February 11, 2019

2017 journal article

Gene duplication and co-evolution of G1/S transcription factor specificity in fungi are essential for optimizing cell fitness

PLOS Genetics, 13(5), e1006778.

By: A. Hendler, E. Medina, A. Kishkevich, M. Abu-Qarn, S. Klier, N. Buchler, R. Bruin, A. Aharoni

Ed(s): M. Snyder

Source: ORCID
Added: February 11, 2019

2017 journal article

Long-term growth data of Escherichia coli at a single-cell level

Scientific Data, 4(1).

By: Y. Tanouchi, A. Pai, H. Park, S. Huang, N. Buchler & L. You

Source: ORCID
Added: February 11, 2019

2017 journal article

The evolution of a G1/S transcriptional network in yeasts

Current Genetics, 64(1), 81–86.

By: A. Hendler, E. Medina, N. Buchler, R. Bruin & A. Aharoni

Source: ORCID
Added: February 11, 2019

2016 journal article

Cell cycle Start is coupled to entry into the yeast metabolic cycle across diverse strains and growth rates.

27(1), 64–74,

By: A. Burnetti, M. Aydin & N. Buchler

Source: ORCID
Added: February 11, 2019

2016 article

Epigenetic switching as a strategy for quick adaptation while constraining biochemical noise

Gómez-Schiavon, M., & Buchler, N. E. (2016, August 30). (Vol. 8). Vol. 8.

By: M. Gómez-Schiavon & N. Buchler

Source: ORCID
Added: July 17, 2019

2016 journal article

Punctuated evolution and transitional hybrid network in an ancestral cell cycle of fungi

ELife, 5.

By: E. Medina, J. Turner, R. Gordân, J. Skotheim & N. Buchler

Source: ORCID
Added: February 11, 2019

2015 journal article

A noisy linear map underlies oscillations in cell size and gene expression in bacteria

Nature, 523(7560), 357–360.

By: Y. Tanouchi, A. Pai, H. Park, S. Huang, R. Stamatov, N. Buchler, L. You

Source: ORCID
Added: February 11, 2019

2015 journal article

Different mechanisms confer gradual control and memory at nutrient- and stress-regulated genes in yeast

Molecular and Cellular Biology, 35(21), 3669–3683.

By: A. Rienzo, D. Poveda-Huertes, S. Aydin, N. Buchler, A. Pascual-Ahuir & M. Proft

Source: ORCID
Added: February 11, 2019

2015 journal article

Redox rhythm reinforces the circadian clock to gate immune response

Nature, 523(7561), 472–476.

By: M. Zhou, W. Wang, S. Karapetyan, M. Mwimba, J. Marqués, N. Buchler, X. Dong

Source: ORCID
Added: February 11, 2019

2015 journal article

Role of DNA binding sites and slow unbinding kinetics in titration-based oscillators.

92(6), 062712,

By: S. Karapetyan, N. Buchler & P. E

Source: ORCID
Added: February 11, 2019

2015 journal article

The Physarum polycephalum Genome Reveals Extensive Use of Prokaryotic Two-Component and Metazoan-Type Tyrosine Kinase Signaling.

Genome Biology and Evolution, 8(1), 109–125,

By: P. Schaap, I. Barrantes, P. Minx, N. Sasaki, R. Anderson, M. Bénard, K. Biggar, N. Buchler ...

Source: ORCID
Added: February 11, 2019

2014 journal article

Measuring fast gene dynamics in single cells with time-lapse luminescence microscopy

Molecular Biology of the Cell, 25(22), 3699–3708.

By: A. Mazo-Vargas, H. Park, M. Aydin & N. Buchler

Source: ORCID
Added: February 11, 2019

2012 journal article

Programming stress-induced altruistic death in engineered bacteria

Molecular Systems Biology, 8.

By: Y. Tanouchi, A. Pai, N. Buchler & L. You

Source: ORCID
Added: February 11, 2019

2011 journal article

Chromatin: Bind at your own RSC

Current Biology, 21(6).

By: N. Buchler & L. Bai

Source: ORCID
Added: February 11, 2019

2011 journal article

Evolution of networks and sequences in eukaryotic cell cycle control

Philosophical Transactions of the Royal Society B: Biological Sciences, 366(1584), 3532–3544.

By: F. Cross, N. Buchler & J. Skotheim

Source: ORCID
Added: February 11, 2019

2009 journal article

Protein sequestration generates a flexible ultrasensitive response in a genetic network

Molecular Systems Biology, 5.

By: N. Buchler & F. Cross

Source: ORCID
Added: February 11, 2019

2008 journal article

Molecular Titration and Ultrasensitivity in Regulatory Networks

Journal of Molecular Biology, 384(5), 1106–1119.

By: N. Buchler & M. Louis

Source: ORCID
Added: February 11, 2019

2007 journal article

Designing sequential transcription logic: A simple genetic circuit for conditional memory

Systems and Synthetic Biology, 1(2), 89–98.

By: G. Fritz, N. Buchler, T. Hwa & U. Gerland

Source: ORCID
Added: February 11, 2019

2005 journal article

Nonlinear protein degradation and the function of genetic circuits

Proceedings of the National Academy of Sciences of the United States of America, 102(27), 9559–9564.

By: N. Buchler, U. Gerland & T. Hwa

Source: ORCID
Added: February 11, 2019

2005 journal article

Transcriptional regulation by the numbers: Applications

Current Opinion in Genetics and Development, 15(2), 125–135.

By: L. Bintu, N. Buchler, H. Garcia, U. Gerland, T. Hwa, J. Kondev, T. Kuhlman, R. Phillips

Source: ORCID
Added: February 11, 2019

2005 journal article

Transcriptional regulation by the numbers: Models

Current Opinion in Genetics and Development, 15(2), 116–124.

By: L. Bintu, N. Buchler, H. Garcia, U. Gerland, T. Hwa, J. Kondev, R. Phillips

Source: ORCID
Added: February 11, 2019

2005 journal article

Two-faced cyclins with eyes on the targets

Cell Cycle, 4(1), 125–130.

By: V. Archambault, N. Buchler, G. Wilmes, M. Jacobson & F. Cross

Source: ORCID
Added: February 11, 2019

2003 journal article

On schemes of combinatorial transcription logic

Proceedings of the National Academy of Sciences of the United States of America, 100(9), 5136–5141.

By: N. Buchler, U. Gerland & T. Hwa

Source: ORCID
Added: February 11, 2019

2000 journal article

Surveying determinants of protein structure designability across different energy models and amino-acid alphabets: A consensus

Journal of Chemical Physics, 112(5), 2533–2547.

By: N. Buchler & R. Goldstein

Source: ORCID
Added: February 11, 2019

1999 journal article

Effect of alphabet size and foldability requirements on protein structure designability

Proteins: Structure, Function and Genetics, 34(1), 113–124.

By: N. Buchler & R. Goldstein

Source: ORCID
Added: February 11, 2019

1999 journal article

Universal correlation between energy gap and foldability for the random energy model and lattice proteins

Journal of Chemical Physics, 111(14), 6599–6609.

By: N. Buchler & R. Goldstein

Source: ORCID
Added: February 11, 2019

1997 journal article

Protein Heteronuclear NMR Assignments Using Mean-Field Simulated Annealing

Journal of Magnetic Resonance, 125(1), 34–42.

By: N. Buchler, E. Zuiderweg, H. Wang & R. Goldstein

Source: ORCID
Added: February 11, 2019

Employment

2018 - present

North Carolina State University Raleigh, NC, US
Associate Professor Molecular Biomedical Sciences

2009 - 2018

Duke University Durham, NC, US
Assistant Professor Biology

Education

1995 - 2001

University of Michigan Ann Arbor, MI, US
Ph.D. Biophysics

1991 - 1995

University of California San Diego La Jolla, CA, US
B.S. Physics

Funding History

Funding history based on the linked ORCID record.

grant April 1, 2018 - March 31, 2022
Measuring and perturbing metabolic rhythms and the cell division cycle in single cells
National Institute of General Medical Sciences
grant February 1, 2018 - January 1, 2021
Determining mechanisms of rewiring of the eukaryotic cell cycle by a virus without disrupting network function
National Science Foundation
grant November 1, 2011 - January 1, 2015
Biochronicity: Time, Evolution, Networks, and Function
Defense Sciences Office, DARPA
grant September 30, 2011 - June 30, 2016
Rewiring the yeast brain: Redundancy and interference in genetic networks
Office of the Director
award July 1, 2006 - June 1, 2016
Career Award at the Scientific Interface
Burroughs Wellcome Fund
grant July 1, 2001 - June 30, 2003
Postdoctoral Research Fellowship in Biological Informatics for FY2001
Directorate for Biological Sciences