Nick Buchler

https://orcid.org/0000-0003-3940-3432

fungi, cell cycle, circadian clocks, quantitative biology, evolution

Works (43)

Updated: July 5th, 2023 15:33
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2022 journal article

Diploid-dominant life cycles characterize the early evolution of Fungi

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 119(36).

By: K. Amses *, D. Simmons *, J. Longcore *, S. Mondo*, K. Seto *, G. Jeronimo *, A. Bonds*, C. Quandt * ...

author keywords: life cycle evolution; phylogenomics; aquatic fungi; plesiomorphy
MeSH headings : Diploidy; Fungi / classification; Fungi / genetics; Genome, Fungal / genetics; Life Cycle Stages; Phylogeny
Sources: Web Of Science, ORCID
Added: December 19, 2022

2022 article

Gene expression noise accelerates the evolution of a biological oscillator

Lin, Y. T., & Buchler, N. E. (2022, March 23). (Vol. 3). Vol. 3.

By: Y. Lin * & N. Buchler  n

Source: ORCID
Added: March 30, 2022

2021 journal article

Competition for DNA binding between paralogous transcription factors determines their genomic occupancy and regulatory functions

GENOME RESEARCH, 31(7), 1216-+.

By: Y. Zhang *, T. Ho*, N. Buchler  n & R. Gordan *

Sources: ORCID, Web Of Science
Added: May 12, 2021

2020 journal article

Chytrid fungi.

Current Biology : CB, 5.

By: E. Medina * & N. Buchler n 

MeSH headings : Animals; Biological Evolution; Cell Cycle; Fungi / classification; Fungi / cytology; Fungi / genetics; Fungi / physiology; Gene Expression Regulation, Fungal
Source: ORCID
Added: May 25, 2020

2020 journal article

Genetic transformation of Spizellomyces punctatus, a resource for studying chytrid biology and evolutionary cell biology

ELife.

By: E. Medina *, K. Robinson*, K. Bellingham-Johnstun  n, G. Ianiri *, C. Laplante  n, L. Fritz-Laylin *, N. Buchler  n

MeSH headings : Actins / metabolism; Biological Evolution; Cell Cycle; Cell Movement; Chytridiomycota / cytology; Chytridiomycota / genetics; Chytridiomycota / growth & development; Fungal Proteins / metabolism; Genome, Fungal; Microorganisms, Genetically-Modified; Mitosis; Morphogenesis; Spores, Fungal / physiology; Transformation, Genetic
Source: ORCID
Added: May 12, 2020

2019 journal article

Enhancer Histone Acetylation Modulates Transcriptional Bursting Dynamics of Neuronal Activity-Inducible Genes

CELL REPORTS, 26(5), 1174-+.

By: L. Chen*, Y. Lin *, D. Gallegos *, M. Hazlett*, M. Gomez-Schiavon *, M. Yang *, B. Kalmeta*, A. Zhou * ...

MeSH headings : Acetylation; Action Potentials; Alleles; Animals; Basic Helix-Loop-Helix Transcription Factors / genetics; Basic Helix-Loop-Helix Transcription Factors / metabolism; CRISPR-Associated Protein 9 / metabolism; CRISPR-Cas Systems; Cell Membrane / metabolism; Enhancer Elements, Genetic / genetics; Gene Expression Regulation; Histones / metabolism; Mice; Neurons / metabolism; Nuclear Proteins / metabolism; Promoter Regions, Genetic; Proto-Oncogene Proteins c-fos / metabolism; RNA, Messenger / genetics; RNA, Messenger / metabolism; Transcription Factors / metabolism; Transcription, Genetic
Sources: Web Of Science, ORCID
Added: February 18, 2019

2019 journal article

Epigenetic switching as a strategy for quick adaptation while attenuating biochemical noise

PLOS COMPUTATIONAL BIOLOGY, 15(10).

By: M. Gomez-Schiavon * & N. Buchler *

MeSH headings : Adaptation, Physiological / genetics; Animals; Biological Evolution; Computer Simulation; Environment; Epigenesis, Genetic / genetics; Epigenesis, Genetic / physiology; Epigenomics / methods; Gene Regulatory Networks / genetics; Genotype; Humans; Models, Genetic; Models, Theoretical; Mutation; Phenotype; Selection, Genetic / genetics
Sources: Web Of Science, ORCID
Added: December 30, 2019

2019 review

Evolutionary innovation, fungal cell biology, and the lateral gene transfer of a viral KilA-N domain

[Review of ]. CURRENT OPINION IN GENETICS & DEVELOPMENT, 58-59, 103–110.

By: E. Medina *, E. Walsh n & N. Buchler  n

MeSH headings : DNA-Binding Proteins / chemistry; DNA-Binding Proteins / genetics; DNA-Binding Proteins / metabolism; Evolution, Molecular; Fungi / genetics; Fungi / metabolism; Gene Transfer, Horizontal / physiology; Membrane Proteins / chemistry; Membrane Proteins / genetics; Membrane Proteins / metabolism; Nuclear Proteins / chemistry; Nuclear Proteins / genetics; Nuclear Proteins / metabolism; Phylogeny; Protein Conformation; Protein Domains / genetics; Repressor Proteins / chemistry; Repressor Proteins / genetics; Repressor Proteins / metabolism; Saccharomyces cerevisiae Proteins / chemistry; Saccharomyces cerevisiae Proteins / genetics; Saccharomyces cerevisiae Proteins / metabolism; Schizosaccharomyces pombe Proteins / chemistry; Schizosaccharomyces pombe Proteins / genetics; Schizosaccharomyces pombe Proteins / metabolism; Transcription Factors / chemistry; Transcription Factors / genetics; Transcription Factors / metabolism; Viral Regulatory and Accessory Proteins / genetics
Sources: Web Of Science, ORCID
Added: December 16, 2019

2019 journal article

Exact and efficient hybrid Monte Carlo algorithm for accelerated Bayesian inference of gene expression models from snapshots of single-cell transcripts

The Journal of Chemical Physics.

By: Y. Lin * & N. Buchler  n

MeSH headings : Algorithms; Bayes Theorem; Gene Expression; Models, Genetic; Monte Carlo Method; Single-Cell Analysis
Source: ORCID
Added: July 10, 2019

2019 journal article

Recognition of Histone Crotonylation by Taf14 Links Metabolic State to Gene Expression

MOLECULAR CELL, 76(6), 909-+.

By: G. Gowans*, J. Bridgers *, J. Zhang*, R. Dronamraju*, A. Burnetti  n, D. King *, A. Thiengmany*, S. Shinsky * ...

MeSH headings : Acyl Coenzyme A / metabolism; Energy Metabolism / genetics; Fatty Acids / metabolism; Gene Expression Regulation, Fungal; Histones / genetics; Histones / metabolism; Homeostasis; Lysine; Oxidation-Reduction; Protein Processing, Post-Translational; Saccharomyces cerevisiae / genetics; Saccharomyces cerevisiae / metabolism; Saccharomyces cerevisiae Proteins / genetics; Saccharomyces cerevisiae Proteins / metabolism; Signal Transduction; Transcription Factor TFIID / genetics; Transcription Factor TFIID / metabolism; Transcription, Genetic
Sources: ORCID, Web Of Science
Added: January 6, 2020

2018 journal article

Daily humidity oscillation regulates the circadian clock to influence plant physiology

NATURE COMMUNICATIONS, 9.

By: M. Mwimba*, S. Karapetyan *, L. Liu *, J. Marques*, E. McGinnis *, N. Buchler  n, X. Dong *

MeSH headings : Arabidopsis / microbiology; Arabidopsis / physiology; Arabidopsis Proteins / genetics; Circadian Clocks / physiology; DNA-Binding Proteins / genetics; Gene Expression Regulation, Plant; Humidity; Mutation; Photoperiod; Plant Immunity; Plants, Genetically Modified; Repressor Proteins / genetics; Transcription Factors / genetics
Sources: Web Of Science, ORCID
Added: October 29, 2018

2018 journal article

Efficient analysis of stochastic gene dynamics in the non-adiabatic regime using piecewise deterministic Markov processes

Journal of The Royal Society Interface, 15(138), 20170804.

By: Y. Lin * & N. Buchler *

author keywords: mathematical model; gene expression; circadian rhythm; intrinsic noise; stochastic cycles
MeSH headings : Biological Clocks; Gene Expression Regulation; Gene Regulatory Networks; Markov Chains; Models, Genetic; Stochastic Processes
Source: ORCID
Added: February 11, 2019

2018 journal article

The evolution of a G1/S transcriptional network in yeasts

Current Genetics, 64(1), 81–86.

By: A. Hendler*, E. Medina *, N. Buchler *, R. Bruin * & A. Aharoni *

author keywords: Cell cycle; Evolution; Gene expression; G1-to-S transition; MBF and SBF
MeSH headings : Biological Evolution; Evolution, Molecular; G1 Phase / genetics; Gene Expression Regulation, Fungal; Gene Regulatory Networks; S Phase / genetics; Saccharomyces cerevisiae / genetics; Saccharomyces cerevisiae / metabolism; Saccharomyces cerevisiae Proteins / genetics; Saccharomyces cerevisiae Proteins / metabolism; Transcription Factors / genetics; Transcription Factors / metabolism; Transcription, Genetic; Yeasts / physiology
Source: ORCID
Added: February 11, 2019

2017 journal article

BayFish: Bayesian inference of transcription dynamics from population snapshots of single-molecule RNA FISH in single cells

Genome Biology, 18(1).

By: M. Gómez-Schiavon *, L. Chen*, A. West * & N. Buchler *

author keywords: Gene expression; Stochastic process; Chemical master equation; Likelihood methods; Monte Carlo sampling; Bayesian posterior probability
MeSH headings : Animals; Basic Helix-Loop-Helix Transcription Factors / genetics; Bayes Theorem; Cells, Cultured; Computational Biology / methods; Female; In Situ Hybridization, Fluorescence; Male; Mice; Models, Genetic; Neurons / metabolism; Probability; RNA / genetics; Software; Stochastic Processes; Transcription, Genetic
Source: ORCID
Added: February 11, 2019

2017 journal article

Conservation and divergence of C-terminal domain structure in the retinoblastoma protein family

Proceedings of the National Academy of Sciences, 114(19), 4942–4947.

By: T. Liban *, E. Medina *, S. Tripathi *, S. Sengupta*, R. Henry*, N. Buchler *, S. Rubin *

author keywords: cell cycle; tumor suppressor protein; E2F; protein-protein interactions; evolution
MeSH headings : Crystallography, X-Ray; E2F Transcription Factors / chemistry; E2F Transcription Factors / genetics; E2F Transcription Factors / metabolism; Humans; Protein Domains; Retinoblastoma Protein / chemistry; Retinoblastoma Protein / genetics; Retinoblastoma Protein / metabolism; Retinoblastoma-Like Protein p107 / chemistry; Retinoblastoma-Like Protein p107 / genetics; Retinoblastoma-Like Protein p107 / metabolism
Source: ORCID
Added: February 11, 2019

2017 journal article

Gene duplication and co-evolution of G1/S transcription factor specificity in fungi are essential for optimizing cell fitness

PLOS Genetics, 13(5), e1006778.

By: A. Hendler, E. Medina, A. Kishkevich, M. Abu-Qarn, S. Klier, N. Buchler, R. Bruin, A. Aharoni

Ed(s): M. Snyder

MeSH headings : Binding Sites; Evolution, Molecular; G1 Phase / genetics; Gene Duplication; Gene Regulatory Networks; Genetic Fitness; Protein Binding; S Phase / genetics; Saccharomyces cerevisiae / genetics; Saccharomyces cerevisiae Proteins / genetics; Saccharomyces cerevisiae Proteins / metabolism; Transcription Factors / genetics; Transcription Factors / metabolism
Source: ORCID
Added: February 11, 2019

2017 journal article

Long-term growth data of Escherichia coli at a single-cell level

Scientific Data.

By: Y. Tanouchi, A. Pai*, H. Park*, S. Huang*, N. Buchler * & L. You *

Source: ORCID
Added: February 11, 2019

2016 journal article

Cell cycle Start is coupled to entry into the yeast metabolic cycle across diverse strains and growth rates.

Molecular Biology of the Cell, 27(1), 64–74,

By: A. Burnetti *, M. Aydin* & N. Buchler* 

MeSH headings : Biological Clocks / physiology; Cell Cycle / genetics; Cell Cycle / physiology; Cell Division / genetics; Cell Division / physiology; DNA Replication; Oxygen / metabolism; Oxygen Consumption / physiology; Partial Pressure; Saccharomycetales / cytology; Saccharomycetales / metabolism
Source: ORCID
Added: February 11, 2019

2016 journal article

Punctuated evolution and transitional hybrid network in an ancestral cell cycle of fungi

ELife, 5.

By: E. Medina *, J. Turner *, R. Gordân *, J. Skotheim * & N. Buchler *

MeSH headings : Cell Cycle; Cell Cycle Proteins / genetics; Cell Cycle Proteins / metabolism; Evolution, Molecular; Fungi / cytology; Fungi / genetics; Fungi / physiology; Gene Transfer, Horizontal; Transcription Factors / genetics; Transcription Factors / metabolism
Source: ORCID
Added: February 11, 2019

2016 journal article

The Physarum polycephalum Genome Reveals Extensive Use of Prokaryotic Two-Component and Metazoan-Type Tyrosine Kinase Signaling

Genome Biology and Evolution, 8(1), 109–125,

By: P. Schaap *, I. Barrantes *, P. Minx, N. Sasaki *, R. Anderson*, M. Bénard*, K. Biggar*, N. Buchler*  ...

author keywords: Amoebozoa; tyrosine kinase receptor; two-component system; signaling; phytochrome
MeSH headings : Cell Cycle Proteins / genetics; Cell Cycle Proteins / metabolism; Evolution, Molecular; Genetic Loci; Genome, Protozoan; Physarum polycephalum / genetics; Protozoan Proteins / genetics; Protozoan Proteins / metabolism; Receptor Protein-Tyrosine Kinases / genetics; Receptor Protein-Tyrosine Kinases / metabolism; Signal Transduction; Transcriptome
Source: ORCID
Added: February 11, 2019

2015 journal article

A noisy linear map underlies oscillations in cell size and gene expression in bacteria

Nature, 523(7560), 357–360.

By: Y. Tanouchi, A. Pai*, H. Park*, S. Huang*, R. Stamatov*, N. Buchler *, L. You *

MeSH headings : Cell Division / genetics; Cell Size; Computer Simulation; Escherichia coli / classification; Escherichia coli / cytology; Escherichia coli / genetics; Escherichia coli / growth & development; Feedback, Physiological; Gene Expression Regulation, Bacterial; Homeostasis / genetics; Models, Biological; Single-Cell Analysis; Time Factors
Source: ORCID
Added: February 11, 2019

2015 journal article

Different mechanisms confer gradual control and memory at nutrient- and stress-regulated genes in yeast

Molecular and Cellular Biology, 35(21), 3669–3683.

By: A. Rienzo*, D. Poveda-Huertes *, S. Aydin *, N. Buchler* , A. Pascual-Ahuir * & M. Proft *

MeSH headings : Galactokinase / genetics; Galactokinase / metabolism; Galactose / metabolism; Gene Expression Regulation, Fungal; Genes, Regulator; Histones / genetics; Histones / metabolism; Mitogen-Activated Protein Kinases / metabolism; Oxidoreductases / genetics; Oxidoreductases / metabolism; RNA Polymerase II / metabolism; Saccharomyces cerevisiae / cytology; Saccharomyces cerevisiae / genetics; Saccharomyces cerevisiae / metabolism; Saccharomyces cerevisiae Proteins / genetics; Saccharomyces cerevisiae Proteins / metabolism; Stress, Physiological; Trans-Activators / metabolism; Transcription Factors / metabolism
Source: ORCID
Added: February 11, 2019

2015 journal article

Redox rhythm reinforces the circadian clock to gate immune response

Nature, 523(7561), 472–476.

By: M. Zhou *, W. Wang *, S. Karapetyan *, M. Mwimba*, J. Marqués*, N. Buchler *, X. Dong *

MeSH headings : Arabidopsis / growth & development; Arabidopsis / immunology; Arabidopsis / metabolism; Arabidopsis / microbiology; Arabidopsis Proteins / biosynthesis; Arabidopsis Proteins / genetics; Arabidopsis Proteins / metabolism; Cell Nucleus / metabolism; Circadian Clocks / drug effects; Circadian Clocks / genetics; Circadian Clocks / physiology; Circadian Rhythm / genetics; Circadian Rhythm / immunology; Circadian Rhythm / physiology; Darkness; Gene Expression Regulation, Plant / drug effects; Gene Expression Regulation, Plant / genetics; Genes, Plant / genetics; Oxidation-Reduction / drug effects; Plant Diseases / microbiology; Plant Immunity / genetics; Plant Immunity / immunology; Pseudomonas syringae / physiology; Salicylic Acid / immunology; Salicylic Acid / metabolism; Salicylic Acid / pharmacology; Transcription Factors / biosynthesis; Transcription Factors / genetics; Transcription, Genetic / genetics
Source: ORCID
Added: February 11, 2019

2015 journal article

Role of DNA binding sites and slow unbinding kinetics in titration-based oscillators.

Physical Review E, 92(6), 062712,

By: S. Karapetyan, N. Buchler*  & P. E

MeSH headings : Binding Sites; Circadian Clocks / genetics; DNA / genetics; DNA / metabolism; Kinetics; Models, Genetic; Stochastic Processes
Source: ORCID
Added: February 11, 2019

2014 journal article

Measuring fast gene dynamics in single cells with time-lapse luminescence microscopy

Molecular Biology of the Cell, 25(22), 3699–3708.

By: A. Mazo-Vargas *, H. Park*, M. Aydin* & N. Buchler* 

MeSH headings : Animals; Cell Cycle / genetics; Cell Cycle Proteins / genetics; Cell Cycle Proteins / metabolism; Coleoptera / chemistry; Coleoptera / enzymology; Fireflies / chemistry; Fireflies / enzymology; Gene Expression Regulation, Fungal; Insect Proteins / chemistry; Insect Proteins / genetics; Insect Proteins / metabolism; Luciferases / chemistry; Luciferases / genetics; Luciferases / metabolism; Luminescent Measurements; Microfluidic Analytical Techniques; Microscopy, Fluorescence; Saccharomyces cerevisiae / genetics; Saccharomyces cerevisiae / metabolism; Saccharomyces cerevisiae Proteins / genetics; Saccharomyces cerevisiae Proteins / metabolism; Single-Cell Analysis / methods; Time-Lapse Imaging
Source: ORCID
Added: February 11, 2019

2014 journal article

Two-Faced Cyclins with Eyes on the Targets

Cell Cycle, 4(1), 125–130.

By: V. Archambault *, N. Buchler* , G. Wilmes, M. Jacobson & F. Cross

author keywords: Clb5; hydrophobic patch; B-type cyclin; RXL; DNA replication
MeSH headings : Amino Acid Motifs; Amino Acid Sequence; Cell Cycle / genetics; Cell Cycle / physiology; Cyclin B / chemistry; Cyclin B / genetics; Cyclin B / physiology; Cyclin-Dependent Kinases / genetics; Cyclin-Dependent Kinases / physiology; Cyclins / genetics; Cyclins / physiology; DNA Replication; Gene Expression Regulation, Fungal; Hydrophobic and Hydrophilic Interactions; Molecular Sequence Data; Origin Recognition Complex / chemistry; Origin Recognition Complex / genetics; Origin Recognition Complex / physiology; Protein Structure, Tertiary; Saccharomyces cerevisiae / genetics; Saccharomyces cerevisiae / physiology; Saccharomyces cerevisiae Proteins / chemistry; Saccharomyces cerevisiae Proteins / genetics; Saccharomyces cerevisiae Proteins / physiology; Signal Transduction / genetics; Signal Transduction / physiology
Source: ORCID
Added: February 16, 2022

2012 journal article

Programming stress-induced altruistic death in engineered bacteria

Molecular Systems Biology, 8.

By: Y. Tanouchi, A. Pai*, N. Buchler*  & L. You *

author keywords: altruistic death; antibiotic response; eagle effect; programmed cell death; synthetic biology
MeSH headings : Apoptosis; Escherichia coli / cytology; Escherichia coli / growth & development; Genetic Engineering; Microbial Viability; Models, Biological; Reproducibility of Results; Stress, Physiological
Source: ORCID
Added: February 11, 2019

2011 journal article

Chromatin: Bind at your own RSC

Current Biology, 21(6).

By: N. Buchler*  & L. Bai *

MeSH headings : Chromatin / metabolism; DNA-Binding Proteins / metabolism; Galactokinase / genetics; Galactokinase / metabolism; Gene Expression Regulation, Fungal / genetics; Gene Expression Regulation, Fungal / physiology; Nucleosomes / metabolism; Promoter Regions, Genetic / genetics; Saccharomyces cerevisiae Proteins / genetics; Saccharomyces cerevisiae Proteins / metabolism; Transcription Factors / metabolism
Source: ORCID
Added: February 11, 2019

2011 journal article

Evolution of networks and sequences in eukaryotic cell cycle control

Philosophical Transactions of the Royal Society B: Biological Sciences, 366(1584), 3532–3544.

By: F. Cross *, N. Buchler*  & J. Skotheim *

author keywords: cell cycle; eukaryotes; evolution; opisthokonts; plants
MeSH headings : Amino Acid Sequence; Animals; Cell Cycle Checkpoints; Cell Cycle Proteins / genetics; Cell Cycle Proteins / metabolism; Conserved Sequence; Eukaryota / classification; Eukaryota / cytology; Eukaryota / genetics; Eukaryota / metabolism; Evolution, Molecular; Mammals; Phylogeny; Plant Cells / metabolism; Plants / classification; Plants / genetics; Plants / metabolism; Sequence Alignment; Yeasts / classification; Yeasts / cytology; Yeasts / genetics; Yeasts / metabolism
Source: ORCID
Added: February 11, 2019

2009 journal article

Protein sequestration generates a flexible ultrasensitive response in a genetic network

Molecular Systems Biology, 5.

By: N. Buchler*  & F. Cross *

author keywords: all-or-none; inhibitor; threshold; titration; transcription
MeSH headings : Basic-Leucine Zipper Transcription Factors / genetics; Basic-Leucine Zipper Transcription Factors / metabolism; Fungal Proteins / genetics; Fungal Proteins / metabolism; Gene Expression Regulation, Fungal; Gene Regulatory Networks; Genes, Dominant; Genetic Engineering / methods; Models, Genetic; Mutation; Saccharomycetales / genetics; Trans-Activators / genetics; Transcription, Genetic
Source: ORCID
Added: February 11, 2019

2008 journal article

Molecular Titration and Ultrasensitivity in Regulatory Networks

Journal of Molecular Biology, 384(5), 1106–1119.

By: N. Buchler*  & M. Louis *

author keywords: dominant negative; sequestration; threshold; titration; ultrasensitive
MeSH headings : Animals; Bacteria; Dimerization; Gene Regulatory Networks; Kinetics; Models, Molecular; Protein Processing, Post-Translational; Saccharomyces cerevisiae; Transcription Factors / metabolism
Source: ORCID
Added: February 11, 2019

2007 journal article

Designing sequential transcription logic: A simple genetic circuit for conditional memory

Systems and Synthetic Biology, 1(2), 89–98.

By: G. Fritz *, N. Buchler* , T. Hwa * & U. Gerland *

Source: ORCID
Added: February 11, 2019

2005 journal article

Nonlinear protein degradation and the function of genetic circuits

Proceedings of the National Academy of Sciences of the United States of America, 102(27), 9559–9564.

By: N. Buchler* , U. Gerland * & T. Hwa *

author keywords: amplification; dimerization; bistability; oscillation
MeSH headings : Bacteria / genetics; Gene Expression Regulation; Models, Biological; Multiprotein Complexes / metabolism; Protein Engineering / methods; Protein Subunits / metabolism; Proteins / metabolism; Transcription Factors / metabolism
Source: ORCID
Added: February 11, 2019

2005 journal article

Transcriptional regulation by the numbers: Applications

Current Opinion in Genetics and Development, 15(2), 125–135.

By: L. Bintu *, N. Buchler* , H. Garcia *, U. Gerland *, T. Hwa *, J. Kondev *, T. Kuhlman *, R. Phillips *

MeSH headings : Animals; Bacteria / genetics; DNA / chemistry; Gene Expression Regulation; Humans; Models, Theoretical; Promoter Regions, Genetic / genetics; Quantitative Trait Loci; Thermodynamics; Transcription, Genetic; Transcriptional Activation
Source: ORCID
Added: February 11, 2019

2005 journal article

Transcriptional regulation by the numbers: Models

Current Opinion in Genetics and Development, 15(2), 116–124.

By: L. Bintu *, N. Buchler* , H. Garcia *, U. Gerland *, T. Hwa *, J. Kondev *, R. Phillips *

MeSH headings : Gene Expression Regulation; Humans; Models, Theoretical; Thermodynamics; Transcription, Genetic
Source: ORCID
Added: February 11, 2019

2005 journal article

Two-faced cyclins with eyes on the targets

Cell Cycle, 4(1), 125–130. http://www.scopus.com/inward/record.url?eid=2-s2.0-14844287697&partnerID=MN8TOARS

By: V. Archambault, N. Buchler , G. Wilmes, M. Jacobson & F. Cross

www.scopus.com
Source: ORCID
Added: February 11, 2019

2003 journal article

On schemes of combinatorial transcription logic

Proceedings of the National Academy of Sciences of the United States of America, 100(9), 5136–5141.

By: N. Buchler* , U. Gerland & T. Hwa

MeSH headings : Bacteria / genetics; Models, Genetic; Transcription, Genetic
Source: ORCID
Added: February 11, 2019

2000 journal article

Surveying determinants of protein structure designability across different energy models and amino-acid alphabets: A consensus

The Journal of Chemical Physics.

Source: ORCID
Added: February 16, 2022

1999 journal article

Effect of alphabet size and foldability requirements on protein structure designability

Proteins: Structure, Function and Genetics, 34(1), 113–124.

By: N. Buchler * & R. Goldstein *

Source: ORCID
Added: February 11, 2019

1999 journal article

Universal correlation between energy gap and foldability for the random energy model and lattice proteins

The Journal of Chemical Physics.

Source: ORCID
Added: February 16, 2022

1997 journal article

Protein Heteronuclear NMR Assignments Using Mean-Field Simulated Annealing

Journal of Magnetic Resonance, 125(1), 34–42.

By: N. Buchler *, E. Zuiderweg *, H. Wang & R. Goldstein *

MeSH headings : Computer Simulation; Magnetic Resonance Spectroscopy / methods; Molecular Weight; Proteins / chemistry
Source: ORCID
Added: February 16, 2022

1997 journal article

Protein Heteronuclear NMR Assignments Using Mean-Field Simulated Annealing

Journal of Magnetic Resonance, 125(1), 34–42. http://www.scopus.com/inward/record.url?eid=2-s2.0-0031083526&partnerID=MN8TOARS

By: N. Buchler, E. Zuiderweg, H. Wang & R. Goldstein

www.scopus.com
Source: ORCID
Added: February 11, 2019

1994 journal article

BL HERCULIS MODEL PULSATIONS .3. LIVERMORE OPACITIES

Astronomy & Astrophysics. https://publons.com/publon/51431452/

publons.com
Source: ORCID
Added: February 16, 2022

Employment

Updated: July 11th, 2018 20:21

2018 - present

North Carolina State University Raleigh, NC, US
Associate Professor Molecular Biomedical Sciences

2009 - 2018

Duke University Durham, NC, US
Assistant Professor Biology

Education

Updated: October 16th, 2014 13:59

1995 - 2001

University of Michigan Ann Arbor, MI, US
Ph.D. Biophysics

1991 - 1995

University of California San Diego La Jolla, CA, US
B.S. Physics

Funding History

Funding history based on the linked ORCID record. Updated: October 15th, 2019 15:25

grant April 1, 2018 - March 31, 2022
Measuring and perturbing metabolic rhythms and the cell division cycle in single cells
National Institute of General Medical Sciences
grant February 1, 2018 - January 1, 2021
Determining mechanisms of rewiring of the eukaryotic cell cycle by a virus without disrupting network function
National Science Foundation
grant November 1, 2011 - January 1, 2015
Biochronicity: Time, Evolution, Networks, and Function
Defense Sciences Office, DARPA
grant September 30, 2011 - June 30, 2016
Rewiring the yeast brain: Redundancy and interference in genetic networks
Office of the Director
award July 1, 2006 - June 1, 2016
Career Award at the Scientific Interface
Burroughs Wellcome Fund
grant July 1, 2001 - June 30, 2003
Postdoctoral Research Fellowship in Biological Informatics for FY2001
Directorate for Biological Sciences