Nathaniel G. Hentz

author keywords: vaccine; residual formaldehyde; formaldehyde assay; high-temperature assay

MeSH headings : Automation, Laboratory; Calibration; Carcinogens / analysis; Carcinogens / chemistry; Disinfectants / analysis; Disinfectants / chemistry; Drug Compounding; Drug Contamination / prevention & control; Drug Stability; Fluorescent Dyes / analysis; Fluorescent Dyes / chemistry; Formaldehyde / analysis; Formaldehyde / chemistry; High-Throughput Screening Assays; Hot Temperature; Hydralazine / chemistry; Hydrogen-Ion Concentration; Indicators and Reagents / chemistry; Influenza Vaccines / chemistry; Limit of Detection; Phthalazines / analysis; Phthalazines / chemistry; Quality Control; Reproducibility of Results; Spectrometry, Fluorescence; Triazoles / analysis; Triazoles / chemistry; Volatilization

TL;DR: An assay was developed that is capable of detecting levels of residual formaldehyde in influenza vaccine samples and has attained detection limits of 0.01 µg/mL residualformaldehyde, which is easily able to detect and quantify formaldehyde at levels used in many current vaccine formulations. (via Semantic Scholar)

MeSH headings : Biochemical Phenomena; High-Throughput Screening Assays / methods; High-Throughput Screening Assays / standards; Inhibitory Concentration 50; Quality Control; Specimen Handling / methods; Specimen Handling / standards

TL;DR: It was found that small changes in assay component volumes were indeed measurable by potency but not necessarily by assay variability (Z-factor), demonstrating how a miscalibrated liquid handler can lead to erroneous data. (via Semantic Scholar)

author keywords: steric effects; bulky ligands; magic sizes; discrete sizes; clusters; gold; thiol

MeSH headings : Adamantane; Crystallization / methods; Cyclohexanes / chemistry; Gold / chemistry; Ligands; Macromolecular Substances / chemistry; Materials Testing; Molecular Conformation; Nanoparticles / chemistry; Nanoparticles / ultrastructure; Particle Size; Sulfhydryl Compounds / chemistry; Surface Properties

TL;DR: Use of bulky ligands in the synthesis of metal nanoparticles (NPs) gives smaller core sizes, sharpens the size distribution, and alters the discrete sizes, which may also lead to the discovery of new discrete sizes in other systems. (via Semantic Scholar)

author keywords: Coenzyme Q(10); Mitochondria; Muscle metabolism; Muscle phenotype; Turkey

MeSH headings : Animals; Blotting, Western; Chromatography, High Pressure Liquid; Immunohistochemistry; Muscle Fibers, Skeletal / classification; Muscle Fibers, Skeletal / metabolism; Muscle, Skeletal / metabolism; Myosins / metabolism; Succinate Dehydrogenase / metabolism; Turkeys / metabolism; Ubiquinone / analogs & derivatives; Ubiquinone / metabolism

TL;DR: Age-related decreases in mitochondrial CoQ10 content in muscles with fast/glycolytic profile are revealed, and it is demonstrated that muscles with a slow/oxidative phenotypic profile contain a higher proportion of Co Q10 than muscles withA fast/ Glycolysis phenotypesic profile. (via Semantic Scholar)