Works (219)

Updated: July 1st, 2024 04:49

2024 journal article

A randomized, controlled clinical trial demonstrates improved owner-assessed cognitive function in senior dogs receiving a senolytic and NAD plus precursor combination

SCIENTIFIC REPORTS, 14(1).

author keywords: Aging; Senolytic; NAD plus; Canine cognitive dysfunction syndrome; Cognitive impairment; Longevity
Sources: Web Of Science, NC State University Libraries
Added: June 24, 2024

2024 article

ACVIM consensus statement on diagnosis and management of urinary incontinence in dogs

Kendall, A., Byron, J. K., Westropp, J. L., Coates, J. R., Vaden, S., Adin, C., … Berent, A. (2024, January 13). JOURNAL OF VETERINARY INTERNAL MEDICINE, Vol. 1.

By: A. Kendall n, J. Byron*, J. Westropp*, J. Coates*, S. Vaden n, C. Adin*, G. Oetelaar, J. Bartges* ...

author keywords: canine; incontinence; urinary
UN Sustainable Development Goal Categories
3. Good Health and Well-being (OpenAlex)
Sources: Web Of Science, NC State University Libraries
Added: February 12, 2024

2024 article

Clinical and imaging findings in dogs with nerve root signature associated with cervical intervertebral disc herniation

Schachar, J., Bocage, A., Nelson, N. C., Early, P. J., Mariani, C. L., Olby, N. J., & Munana, K. R. (2024, January 12). JOURNAL OF VETERINARY INTERNAL MEDICINE, Vol. 1.

By: J. Schachar n, A. Bocage n, N. Nelson n, P. Early n, C. Mariani n, N. Olby n, K. Munana n

author keywords: cervical radiculopathy; intraforaminal disc herniation; magnetic resonance imaging; thoracic limb lameness
TL;DR: NRS is most prevalent with C6‐C7 intervertebral disc involvement, suggesting that there might be unique anatomic factors that contribute to development of NRS at this site, but can be a clinical manifestation of IVDH occurring anywhere along the cervical spine. (via Semantic Scholar)
Sources: Web Of Science, NC State University Libraries, ORCID
Added: January 13, 2024

2024 article

Pharmacokinetics of subcutaneous ketamine administration via the Omnipod® system in dogs

Colon, C., Early, P., Munana, K., Olby, N., Mariani, C., Mancini, S., … Messenger, K. (2024, March 27). JOURNAL OF VETERINARY PHARMACOLOGY AND THERAPEUTICS, Vol. 3.

By: C. Colon n, P. Early n, K. Munana n, N. Olby n, C. Mariani n, S. Mancini n, G. Fefer n, Z. Li* ...

author keywords: analgesia; canine; ketamine; novel; veterinary
UN Sustainable Development Goal Categories
3. Good Health and Well-being (OpenAlex)
Sources: Web Of Science, NC State University Libraries
Added: April 8, 2024

2023 journal article

A novel task of canine olfaction for use in adult and senior pet dogs

SCIENTIFIC REPORTS, 13(1).

By: M. Khan n, A. Mondino n, K. Russell n, B. Case n, G. Fefer n, H. Woods n, N. Olby n, M. Gruen n

MeSH headings : Dogs; Animals; Smell; Food; Aging; Neuropsychological Tests
TL;DR: A novel olfaction test using spontaneous search behavior in dogs to find a hidden food treat in a three-choice task with both light-phase and dark-phase conditions is described, making it feasible to compare between and within groups of pet dogs. (via Semantic Scholar)
Sources: ORCID, Web Of Science, NC State University Libraries
Added: February 19, 2023

2023 review

A review of frailty instruments in human medicine and proposal of a frailty instrument for dogs

[Review of ]. FRONTIERS IN VETERINARY SCIENCE, 10.

By: R. Melvin*, A. Ruple*, E. Pearson*, N. Olby n, A. Fitzpatrick* & K. Creevy*

author keywords: aging; age-related disease; geriatric; phenotype; resilience
TL;DR: A phenotypic frailty instrument for companion dogs, utilizing components that are easily collected by owners, or in the general practice setting, is proposed, and factors that will be included, and the data from the Dog Aging Project that inform each domain are elaborate. (via Semantic Scholar)
Sources: Web Of Science, NC State University Libraries
Added: July 19, 2023

2023 journal article

Activity patterns are associated with fractional lifespan, memory, and gait speed in aged dogs

SCIENTIFIC REPORTS, 13(1).

By: A. Mondino n, M. Khan n, B. Case n, S. Giovagnoli*, A. Thomson n, B. Lascelles n, M. Gruen n, N. Olby n

MeSH headings : Humans; Dogs; Animals; Alzheimer Disease; Longevity; Walking Speed; Gait; Cognition; Cognitive Dysfunction; Aging / psychology; Pain
TL;DR: It is found that activity patterns in dogs are associated with fractional lifespan and working memory, and dogs with higher on/off leash gait speed are more active in the afternoon of weekdays. (via Semantic Scholar)
Sources: ORCID, Web Of Science, NC State University Libraries
Added: February 19, 2023

2023 article

Age-associated changes in electroretinography measures in companion dogs

Salzman, M. M., Merten, N., Panek, W. K., Fefer, G., Mondino, A., Westermeyer, H. D., … Mowat, F. M. (2023, June 11). DOCUMENTA OPHTHALMOLOGICA, Vol. 6.

author keywords: Translational model; Aging; Retina; ERG; Canine; Anxiolytic
TL;DR: Consideration of anxiolytic medication use should be made when conducting ERG studies in dogs, as aged companion dogs have slower and reduced amplitude responses in both rod- and cone-mediated ERG. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Sources: Web Of Science, NC State University Libraries, ORCID
Added: June 19, 2023

2023 article

Association of the FGF4L2 retrogene with fibrocartilaginous embolic myelopathy in dogs

Embersics, C., Bannasch, D., Batcher, K., Boudreau, E. C., Church, M., Miller, A., … Dickinson, P. J. (2023, November 2). JOURNAL OF VETERINARY INTERNAL MEDICINE, Vol. 11.

By: C. Embersics*, D. Bannasch*, K. Batcher*, E. Boudreau*, M. Church*, A. Miller*, S. Platt, J. Koehler* ...

author keywords: canine; chondrodystrophy; FCE; fibroblast growth factor
TL;DR: Study data based on genotypically and histopathologically defined cases support the historical observation that FCE is uncommon in chondrodystrophic dog breeds. (via Semantic Scholar)
UN Sustainable Development Goal Categories
14. Life Below Water (OpenAlex)
Sources: ORCID, Web Of Science, NC State University Libraries
Added: November 27, 2023

2023 journal article

Development and validation of a sleep questionnaire, SNoRE 3.0, to evaluate sleep in companion dogs

SCIENTIFIC REPORTS, 13(1).

By: A. Mondino n, C. Ludwig n, C. Menchaca n, K. Russell n, K. Simon n, E. Griffith n, A. Kis*, B. Lascelles n, M. Gruen n, N. Olby n

TL;DR: A valid and reliable questionnaire tool is described, that can be used as a cost-effective way to monitor dog sleep in clinical settings. (via Semantic Scholar)
UN Sustainable Development Goal Categories
8. Decent Work and Economic Growth (OpenAlex)
Sources: Web Of Science, NC State University Libraries
Added: October 23, 2023

2023 article

Diagnosis and management of dogs with degenerative myelopathy: A survey of neurologists and rehabilitation professionals

Bouche, T. V., Coates, J. R., Moore, S. A., Faissler, D., Rishniw, M., & Olby, N. J. (2023, August 22). JOURNAL OF VETERINARY INTERNAL MEDICINE, Vol. 8.

By: T. Bouche n, J. Coates*, S. Moore*, D. Faissler*, M. Rishniw* & N. Olby n

author keywords: amyotrophic lateral sclerosis; degenerative; rehabilitation; SOD1; spinal cord
TL;DR: The majority of dogs diagnosed with DM have not undergone advanced imaging, the combination of history, neurological findings, and genetic testing is heavily relied upon, and continued care is often performed by rehabilitation professionals or primary veterinarians. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (Web of Science; OpenAlex)
Sources: Web Of Science, NC State University Libraries, ORCID
Added: September 5, 2023

2023 journal article

Longitudinal Analysis of Canine Oral Microbiome Using Whole Genome Sequencing in Aging Companion Dogs

ANIMALS, 13(24).

author keywords: oral; microbiome; canine cognitive dysfunction syndrome; Alzheimer's disease
TL;DR: The importance of defining the oral microbiota in aged dogs with a view to understanding potential therapeutic targets is shown, with an increased fungal and bacterial alpha diversity in aging dogs over time and nearly universal oral dysbiosis. (via Semantic Scholar)
Sources: Web Of Science, NC State University Libraries
Added: January 16, 2024

2023 article

MRI features can help to confirm a diagnosis of progressive myelomalacia, but may not be accurate in dogs lacking characteristic clinical signs at the time of imaging

Cordle, K. J., Seiler, G. S., Barnes, D., & Olby, N. J. (2023, January 20). VETERINARY RADIOLOGY & ULTRASOUND, Vol. 1.

By: K. Cordle n, G. Seiler n, D. Barnes n & N. Olby n

author keywords: ascending-descending myelomalacia; canine; intervertebral disc disease; MRI; spinal cord injury
MeSH headings : Dogs; Animals; Retrospective Studies; Case-Control Studies; Dog Diseases / diagnostic imaging; Dog Diseases / pathology; Spinal Cord Diseases / veterinary; Intervertebral Disc Displacement / diagnostic imaging; Intervertebral Disc Displacement / veterinary; Magnetic Resonance Imaging / veterinary
TL;DR: MRI features can support the diagnosis in dogs with clinical evidence of progressive myelomalacia, and absence of these features supports absence of PMM at time of imaging, however, their absence does not reliably differentiate dogs with imminent progressive myELomalacia from other dogs with severe deficits following intervertebral disc extrusion. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (Web of Science; OpenAlex)
Sources: Web Of Science, NC State University Libraries
Added: February 6, 2023

2023 journal article

Magnetic resonance imaging characteristics of atlanto-axial subluxation in 42 dogs: Analysis of joint cavity size, subluxation distance, and craniocervical junction anomalies

OPEN VETERINARY JOURNAL, 13(9), 1091–1098.

By: K. Bray, S. Platt, M. Kent, N. Olby*, P. Early*, C. Mariani*, K. Munana, S. Holmes

author keywords: Canine; Cervical; Congenital; Malformation; Myelopathy
TL;DR: Dogs with clinical signs of AA subluxation were significantly more likely to have intramedullary hyperintensity at the level of compression, an increased AA joint cavity size, and increased spinal cord compression at thelevel of dens and mid-body C2, according to MRI characteristics. (via Semantic Scholar)
Sources: Web Of Science, NC State University Libraries
Added: January 16, 2024

2023 article

Phenotypic and genetic aspects of hereditary ataxia in dogs

Stee, K., Van Poucke, M., Lowrie, M., Van Ham, L., Peelman, L., Olby, N., & Bhatti, S. F. M. (2023, June 21). JOURNAL OF VETERINARY INTERNAL MEDICINE, Vol. 6.

author keywords: (spino)cerebellar; canine; gene; genetic variant; multiple system degeneration; neuronal ceroid lipofuscinosis
TL;DR: A “multifocal degenerations with predominant (spino)cerebellar component” category is proposed regrouping canine multiple system degeneration, new hereditary ataxia syndromes that do not fit in 1 of the previous categories, as well as specific neuroaxonal dystrophies and lysosomal storage diseases that cause major (Spino)Cerebellar dysfunction. (via Semantic Scholar)
Sources: Web Of Science, NC State University Libraries, ORCID
Added: July 3, 2023

2023 article

Presumed pituitary apoplexy in 26 dogs: Clinical findings, treatments, and outcomes

Woelfel, C. W., Mariani, C. L., Nolan, M. W., Keenihan, E. K., Topulos, S. P., Early, P. J., … Olby, N. J. (2023, April 21). JOURNAL OF VETERINARY INTERNAL MEDICINE, Vol. 4.

By: C. Woelfel n, C. Mariani n, M. Nolan n, E. Keenihan n, S. Topulos n, P. Early n, K. Munana n, S. Musulin n, N. Olby n

author keywords: adenoma; carcinoma; endocrionopathy; hemorrhage; magnetic resonance imaging; suprasellar; survival
MeSH headings : Dogs; Animals; Pituitary Apoplexy / therapy; Pituitary Apoplexy / veterinary; Pituitary Apoplexy / diagnosis; Pituitary Neoplasms / complications; Pituitary Neoplasms / diagnostic imaging; Pituitary Neoplasms / therapy; Pituitary Neoplasms / veterinary; Retrospective Studies; Hydrocephalus / veterinary; Infarction / veterinary; Magnetic Resonance Imaging / veterinary; Dog Diseases / diagnostic imaging; Dog Diseases / therapy
TL;DR: Dogs with pituitary apoplexy present with a variety of acute signs of neurological disease and inconsistent endocrine dysfunction and dogs that survive to discharge can have a favorable outcome. (via Semantic Scholar)
Sources: Web Of Science, NC State University Libraries, ORCID
Added: April 22, 2023

2023 journal article

Relationship between engagement with the impossible task, cognitive testing, and cognitive questionnaires in a population of aging dogs

FRONTIERS IN VETERINARY SCIENCE, 9.

By: M. Khan n, A. Mondino n, K. Russell n, B. Case n, G. Fefer n, H. Woods n, N. Olby n, M. Gruen n

author keywords: canine cognitive dysfunction syndrome; canine cognition; frustration; aging; dogs
TL;DR: The high correlation with several cognitive measures and the ease of administration of this test makes it a useful tool in evaluating canine cognitive dysfunction syndrome, however it is unclear if increased frustration or other cognitive processes are contributing to the observed changes. (via Semantic Scholar)
Sources: Web Of Science, NC State University Libraries
Added: February 6, 2023

2023 journal article

Sleep and cognition in aging dogs. A polysomnographic study

FRONTIERS IN VETERINARY SCIENCE, 10.

By: A. Mondino n, M. Catanzariti*, D. Mateos*, M. Khan n, C. Ludwig n, A. Kis*, M. Gruen n, N. Olby n

author keywords: NREM sleep; REM sleep; canine cognitive dysfunction syndrome; quantitative EEG; power spectrum; coherence; complexity
TL;DR: Polysomnographic recordings in dogs can detect sleep-wakefulness cycle changes associated with dementia, and their potential clinical use to monitor the progression of canine cognitive dysfunction syndrome is evaluated. (via Semantic Scholar)
Sources: Web Of Science, NC State University Libraries
Added: May 22, 2023

2023 journal article

Winning the race with aging: age-related changes in gait speed and its association with cognitive performance in dogs

FRONTIERS IN VETERINARY SCIENCE, 10.

By: A. Mondino n, M. Khan n, B. Case n, G. Fefer n, W. Panek n, M. Gruen n, N. Olby n

author keywords: canine cognitive dysfunction syndrome; canine gerontology; mobility; walking speed; memory; attention
TL;DR: Dogs' food-motivated gait speed off leash is correlated with fractional lifespan and cognitive performance in dogs, particularly in the domains of attention and working memory and proves to be a more effective indicator of age-related deterioration and cognitive decline than gaitspeed on leash. (via Semantic Scholar)
Sources: Web Of Science, NC State University Libraries
Added: July 24, 2023

2022 article

A novel mutation of the CLCN1 gene in a cat with myotonia congenita: Diagnosis and treatment

Woelfel, C., Meurs, K., Friedenberg, S., DeBruyne, N., & Olby, N. J. (2022, July 11). JOURNAL OF VETERINARY INTERNAL MEDICINE, Vol. 7.

By: C. Woelfel n, K. Meurs n, S. Friedenberg*, N. DeBruyne n & N. Olby n

author keywords: chloride channel; electromyography; nondystrophic myotonia; phenytoin
MeSH headings : Animals; Cat Diseases / diagnosis; Cat Diseases / drug therapy; Cat Diseases / genetics; Cats; Chloride Channels / genetics; Electromyography / veterinary; Exons; Male; Mutation; Myotonia Congenita / diagnosis; Myotonia Congenita / drug therapy; Myotonia Congenita / genetics; Myotonia Congenita / veterinary
TL;DR: Phenytoin treatment was initiated at 3 mg/kg po q24 h and resulted in long‐term improvement and is reported for the first time its successful treatment. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (Web of Science; OpenAlex)
Sources: Web Of Science, NC State University Libraries, ORCID
Added: July 18, 2022

2022 article

ACVIM consensus statement on diagnosis and management of acute canine thoracolumbar intervertebral disc extrusion

Olby, N. J., Olby, N., Moore, S., Brisson, B., Fenn, J., Flegel, T., … Tipold, A. (2022, July 25). JOURNAL OF VETERINARY INTERNAL MEDICINE, Vol. 7.

By: N. Olby*, N. Olby, S. Moore n, B. Brisson, J. Fenn*, T. Flegel*, G. Kortz*, M. Lewis*, A. Tipold*

author keywords: dog; intervertebral disc herniation; paralysis; spinal cord injury
MeSH headings : Animals; Decompression, Surgical / veterinary; Dog Diseases / diagnosis; Dog Diseases / etiology; Dog Diseases / therapy; Dogs; Intervertebral Disc / surgery; Intervertebral Disc Displacement / diagnosis; Intervertebral Disc Displacement / therapy; Intervertebral Disc Displacement / veterinary; Prospective Studies; Retrospective Studies
TL;DR: Recommendations include better understanding of the ideal timing for surgical decompression, expected surgical vs medical outcomes for more mildly affected dogs, impact of durotomy on locomotor outcome and development of progressive myelomalacia, and refining of postoperative care, and genetic and preventative care studies. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Sources: Web Of Science, NC State University Libraries, ORCID
Added: August 1, 2022

2022 journal article

Bayesian model and selection signature analyses reveal risk factors for canine atopic dermatitis

COMMUNICATIONS BIOLOGY, 5(1).

MeSH headings : Animals; Dogs / genetics; Bayes Theorem; Dermatitis, Atopic / genetics; Dermatitis, Atopic / veterinary; Risk Factors
TL;DR: A Bayesian mixture model adapted for mapping complex traits and a cross-population extended haplotype test is applied to search for disease-associated loci and selective sweeps in four dog breeds at risk for atopic dermatitis and identifies candidate genes, including genes belonging to the same biological pathways across multiple loci, with potential relevance to the pathogenesis of canine atopy dermatitis. (via Semantic Scholar)
Sources: ORCID, Web Of Science, NC State University Libraries
Added: February 19, 2023

2022 journal article

Canine Geriatric Syndrome: A Framework for Advancing Research in Veterinary Geroscience

FRONTIERS IN VETERINARY SCIENCE, 9.

By: B. McKenzie, F. Chen, M. Gruen n & N. Olby n

author keywords: aging; lifespan; healthspan; quality of life; caregiver burden
TL;DR: A new conceptual framework for aging in dogs, the Canine Geriatric Syndrome (CGS), which consists of the multiple, interrelated physical, functional, behavioral, and metabolic changes that characterize canine aging as well as the resulting clinical manifestations, including frailty, diminished quality of life, and age-associated disease is proposed. (via Semantic Scholar)
Sources: Web Of Science, NC State University Libraries
Added: November 14, 2022

2022 article

Clinical signs, MRI findings and long-term outcomes of foraminal and far lateral thoracolumbar intervertebral disc herniations in dogs

Silva, S., Guevar, J., Jose-Lopez, R., De Decker, S., Brocal, J., Fuente, C., … Gutierrez-Quintana, R. (2022, March 12). VETERINARY RECORD, Vol. 3.

MeSH headings : Animals; Dog Diseases / diagnostic imaging; Dog Diseases / etiology; Dog Diseases / surgery; Dogs; Intervertebral Disc / diagnostic imaging; Intervertebral Disc / pathology; Intervertebral Disc Displacement / complications; Intervertebral Disc Displacement / diagnostic imaging; Intervertebral Disc Displacement / surgery; Intervertebral Disc Displacement / veterinary; Lameness, Animal / etiology; Lumbar Vertebrae / diagnostic imaging; Magnetic Resonance Imaging / veterinary; Pain / etiology; Pain / veterinary; Retrospective Studies; Thoracic Vertebrae / diagnostic imaging
TL;DR: Although much less frequently recognised than herniation affecting the vertebral canal, foraminal and far lateral thoracolumbar intervertebral disc herniations should be considered in the differential diagnosis list of chondrodystrophic dogs presenting with pain and pelvic limb lameness. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (Web of Science; OpenAlex)
Sources: Web Of Science, NC State University Libraries, ORCID
Added: March 28, 2022

2022 article

Developing a predictive model for spinal shock in dogs with spinal cord injury

McBride, R., Parker, E., Garabed, R. B., Olby, N. J., Tipold, A., Stein, V. M., … Moore, S. A. (2022, January 10). JOURNAL OF VETERINARY INTERNAL MEDICINE, Vol. 1.

By: R. McBride*, E. Parker*, R. Garabed*, N. Olby n, A. Tipold*, V. Stein*, N. Granger*, A. Hechler*, P. Yaxley*, S. Moore*

author keywords: fibrocartilaginous infarct; herniation; intervertebral disc disease; neurology; spinal cord disease; spinal shock
MeSH headings : Animals; Dog Diseases / diagnosis; Dogs; Humans; Intervertebral Disc Displacement / veterinary; Paraplegia / veterinary; Spinal Cord / pathology; Spinal Cord Diseases / veterinary; Spinal Cord Injuries / complications; Spinal Cord Injuries / diagnosis; Spinal Cord Injuries / veterinary
TL;DR: A formula, as developed by the present study and after external validation, could be useful for assisting clinicians in determining the likelihood of spinal shock in various clinical scenarios and aid in diagnostic planning. (via Semantic Scholar)
Sources: Web Of Science, NC State University Libraries, ORCID
Added: January 18, 2022

2022 article

Electroencephalographic Signatures of Canine Cognitive Dysfunction

Mondino, A., Gutiérrez, M., González, C., Mateos, D., Torterolo, P., Olby, N., & Delucchi, L. (2022, February 1).

By: A. Mondino n, M. Gutiérrez, C. González, D. Mateos*, P. Torterolo*, N. Olby n, L. Delucchi

TL;DR: Electroencephalogram findings specific to AD are described and demonstrated that, quantitative EEG can detect differences between normal dogs and dogs with CCD, and reinforce the CCD as a translational model of AD. (via Semantic Scholar)
Source: ORCID
Added: February 19, 2023

2022 journal article

Electroencephalographic signatures of dogs with presumptive diagnosis of canine cognitive dysfunction

RESEARCH IN VETERINARY SCIENCE, 150, 36–43.

By: A. Mondino n, M. Gutierrez, C. Gonzalez, D. Mateos*, P. Torterolo*, N. Olby n, L. Delucchi

author keywords: Aging; Alzheimer'sdisease; Onehealth; Cognition
MeSH headings : Animals; Cognition Disorders / diagnosis; Cognition Disorders / psychology; Cognitive Dysfunction / diagnosis; Dog Diseases / diagnosis; Dogs; Electroencephalography / veterinary; Humans; Neurodegenerative Diseases / veterinary; Quality of Life
TL;DR: It is demonstrated that quantitative EEG analysis could aid the diagnosis of CCD, and reinforce the CCD as a translational model of early AD. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Sources: Web Of Science, NC State University Libraries
Added: August 15, 2022

2022 journal article

Novel subcutaneous cytarabine infusion with the Omnipod system in dogs with meningoencephalomyelitis of unknown etiology

AMERICAN JOURNAL OF VETERINARY RESEARCH, 83(9).

By: S. Mancini n, P. Early n, B. Slater n, N. Olby n, C. Mariani n, K. Munana n, C. Woelfel n, J. Schacher n, L. Zhong n, K. Messenger n

MeSH headings : Animals; Area Under Curve; Chromatography, High Pressure Liquid / veterinary; Cytarabine / therapeutic use; Dogs; Half-Life; Humans; Infusions, Intravenous / veterinary; North Carolina
TL;DR: An SC continuous-rate infusion of cytarabine via the Omnipod system is feasible in dogs and was able to achieve a steady-state concentration of more than 1 μg/mL 4 to 10 hours postinitiation of cyTarabine and a Cmax of 7,510 ng/mL, comparable to values reported previously with IV continuous- rate infusion administration in healthy research Beagles and dogs with meningoencephalomyelitis of unknown etiology. (via Semantic Scholar)
Sources: Web Of Science, NC State University Libraries
Added: August 1, 2022

2022 article

Relationship between hearing, cognitive function, and quality of life in aging companion dogs

Fefer, G., Khan, M. Z., Panek, W. K., Case, B., Gruen, M. E., & Olby, N. J. (2022, August 6). JOURNAL OF VETERINARY INTERNAL MEDICINE, Vol. 8.

By: G. Fefer n, M. Khan n, W. Panek n, B. Case n, M. Gruen n & N. Olby n

author keywords: canine cognitive dysfunction syndrome; CCDS; cognitive testing; dementia; presbycusis
MeSH headings : Aging; Animals; Cognition; Dementia / epidemiology; Dog Diseases; Dogs; Hearing; Humans; Pets; Presbycusis / epidemiology; Presbycusis / veterinary; Prospective Studies; Quality of Life
TL;DR: Presbycusis negatively alters owner‐pet interactions and is associated with poor executive performance and owner‐assessed dementia severity, and in multivariate analysis, higher CADES score was associated with worse hearing. (via Semantic Scholar)
UN Sustainable Development Goal Categories
1. No Poverty (OpenAlex)
Sources: Web Of Science, NC State University Libraries, ORCID
Added: August 22, 2022

2022 journal article

Static posturography as a novel measure of the effects of aging on postural control in dogs

PLOS ONE, 17(7).

By: A. Mondino n, G. Wagner n, K. Russell n, E. Lobaton n, E. Griffith n, M. Gruen n, B. Lascelles n, N. Olby n

Ed(s): R. Evans

MeSH headings : Acceleration; Aging; Animals; Arthralgia; Dogs; Postural Balance; Reproducibility of Results
TL;DR: It is found that pressure sensitive walkway systems are a reliable tool to evaluate postural sway in dogs; and that postural swayed is affected by morphometric parameters and increases with age and joint pain. (via Semantic Scholar)
Sources: Web Of Science, NC State University Libraries, ORCID
Added: September 12, 2022

2022 journal article

Stereotactic radiotherapy (10 Gy X 3) for canine nonlymphomatous intranasal tumors is associated with prolonged survival and minimal risk of severe radiotoxicity

JAVMA-JOURNAL OF THE AMERICAN VETERINARY MEDICAL ASSOCIATION, 260(12), 1496–1506.

By: M. Nolan n, A. Berman n, M. Watson-Skaggs n, C. Quinn n, K. Marcus n, K. Russell n, H. Yoshikawa n, N. Olby n, T. Gieger n

MeSH headings : Dogs; Animals; Retrospective Studies; Dog Diseases / surgery; Quality of Life; Radiosurgery / methods; Radiosurgery / veterinary; Chondrosarcoma / veterinary; Bone Neoplasms / veterinary; Death; Treatment Outcome
TL;DR: Oncologic outcomes following administration of a uniform stereotactic radiotherapy protocol for canine intranasal tumors are described and any clinical or dosimetric factors were predictive of event-free or overall survival time (EFST or OST) are identified. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Sources: Web Of Science, NC State University Libraries
Added: February 13, 2023

2022 journal article

Use of Cognitive Testing, Questionnaires, and Plasma Biomarkers to Quantify Cognitive Impairment in an Aging Pet Dog Population

JOURNAL OF ALZHEIMERS DISEASE, 87(3), 1367–1378.

By: G. Fefer n, W. Panek n, M. Khan n, M. Singer n, H. Westermeyer n, F. Mowat n, D. Murdoch*, B. Case n, N. Olby n, M. Gruen n

author keywords: Blood biomarkers; canine cognitive dysfunction syndrome; CCDS; cognitive testing; dementia; neurofilament light chain; NfL
TL;DR: It is suggested that a multi-dimensional approach using a combination of questionnaires, specific cognitive tests, and pNfL concentration can be used to quantify cognitive decline in aging pet dogs. (via Semantic Scholar)
UN Sustainable Development Goal Categories
10. Reduced Inequalities (OpenAlex)
Sources: Web Of Science, NC State University Libraries
Added: June 20, 2022

2021 journal article

A CTSA One Health Alliance (COHA) survey of clinical trial infrastructure in North American veterinary institutions

BMC VETERINARY RESEARCH, 17(1).

By: S. Moore*, A. McCleary-Wheeler*, J. Coates*, N. Olby n & C. London*

MeSH headings : Animals; Clinical Trials, Veterinary as Topic; One Health; Research / economics; Research / statistics & numerical data; Schools, Veterinary / economics; Schools, Veterinary / statistics & numerical data; Surveys and Questionnaires
TL;DR: An electronic survey of North American Veterinary Colleges regarding practices in veterinary clinical trial review, approval, conduct, and support was conducted in order to identify opportunities to leverage existing resources and develop new ones to enhance the impact of veterinary and translational health research. (via Semantic Scholar)
Sources: Web Of Science, NC State University Libraries
Added: March 15, 2021

2021 journal article

A novel missense mutation of the NAT10 gene in a juvenile Schnauzer dog with chronic respiratory tract infections

JOURNAL OF VETERINARY INTERNAL MEDICINE, 35(3), 1542–1546.

By: B. Hedgespeth n, A. Birkenheuer n, S. Friedenberg*, N. Olby n & K. Meurs n

author keywords: ciliary dysplasia; congenital; genetics; microtubule; pneumonia; whole genome sequencing
MeSH headings : Animals; Dog Diseases / genetics; Dogs; Male; Mutation; Mutation, Missense; Respiratory Tract Infections / genetics; Respiratory Tract Infections / veterinary; Whole Genome Sequencing / veterinary
TL;DR: W Whole genome sequencing discovered a deleterious missense A/C mutation within the NAT10 gene, a gene essential for microtubule acetylation, appropriate ciliary development, and cytokinesis, suggesting a pathophysiological mechanism for this dog and highlighting an associated mutation or possible novel genetic cause of chronic respiratory infections in dogs. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (Web of Science; OpenAlex)
Sources: Web Of Science, NC State University Libraries, ORCID
Added: March 29, 2021

2021 article

ALSUntangled #63: ketogenic diets

Bedlack, R., Barkhaus, P. E., Barnes, B., Beauchamp, M., Bertorini, T., Bromberg, M. B., … Wills, A.-M. (2021, October 13). AMYOTROPHIC LATERAL SCLEROSIS AND FRONTOTEMPORAL DEGENERATION, Vol. 10.

By: R. Bedlack*, P. Barkhaus*, B. Barnes*, M. Beauchamp n, T. Bertorini*, M. Bromberg*, G. Carter, V. Chaudry* ...

author keywords: Ketone; ketogenic diet; alsuntangled; mitochondria; transgenic animals; therapy
MeSH headings : Mice; Animals; Humans; Diet, Ketogenic; Amyotrophic Lateral Sclerosis
TL;DR: It is concluded that there is yet not enough data to recommend ketogenic diets for patients with ALS, especially in light of the many side effects these can have. (via Semantic Scholar)
UN Sustainable Development Goal Categories
7. Affordable and Clean Energy (OpenAlex)
Sources: Web Of Science, NC State University Libraries
Added: November 1, 2021

2021 journal article

Association between filum terminale internum length and pain in Cavalier King Charles spaniels with and without syringomyelia

JOURNAL OF VETERINARY INTERNAL MEDICINE, 35(1), 363–371.

By: C. Sparks n, C. Woelfel n, I. Robertson n & N. Olby n

author keywords: Chiari-like malformation; conus medullaris; dural sac; morphometry; tethered cord
MeSH headings : Animals; Cauda Equina / diagnostic imaging; Dog Diseases; Dogs; Magnetic Resonance Imaging / veterinary; Pain / veterinary; Prospective Studies; Reproducibility of Results; Syringomyelia / diagnostic imaging; Syringomyelia / veterinary
TL;DR: Painful CKCS without SM have decreased distance between the termination of the spinal cord and dural sac, suggesting a shorter FTIL, and more caudal spinal cord termination is associated with development of lumbar SM. (via Semantic Scholar)
Sources: Web Of Science, NC State University Libraries, ORCID
Added: February 1, 2021

2021 journal article

Canine junctional epidermolysis bullosa due to a novel mutation in LAMA3 with severe upper respiratory involvement

VETERINARY DERMATOLOGY, 32(4), 379-+.

MeSH headings : Animals; Australia; Cattle; Dog Diseases / genetics; Dogs; Epidermolysis Bullosa, Junctional / genetics; Epidermolysis Bullosa, Junctional / veterinary; Laminin / genetics; Mutation, Missense; Nail Diseases / genetics; Nail Diseases / veterinary
TL;DR: A novel variant in LAMA3 caused a generalized and severe phenotype of JEB with an unique clinical presentation of upper airway obstruction in a litter of puppies with severe upper respiratory involvement. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (Web of Science; OpenAlex)
Sources: Web Of Science, NC State University Libraries, ORCID
Added: July 19, 2021

2021 journal article

Continuous rate infusion of midazolam as emergent treatment for seizures in dogs

Journal of Veterinary Internal Medicine.

By: K. Bray n, C. Mariani n, P. Early n, K. Muñana n & N. Olby n

author keywords: acute repetitive seizures; anticonvulsant; benzodiazepine; canine; cluster seizures; epilepsy; status epilepticus
MeSH headings : Animals; Anticonvulsants / adverse effects; Dog Diseases / drug therapy; Dogs; Hospitals, Animal; Hospitals, Teaching; Midazolam / therapeutic use; Retrospective Studies; Seizures / drug therapy; Seizures / veterinary
TL;DR: Midazolam CRI is apparently safe and might be an effective treatment in dogs with CS or SE, and dogs with idiopathic/unknown epilepsy were more likely to survive than those with structural epilepsy. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (Web of Science; OpenAlex)
Source: ORCID
Added: December 17, 2020

2021 article

Editorial: Canine Intervertebral Disc Disease: The Current State of Knowledge

Olby, N. J., & Tipold, A. (2021, March 16). FRONTIERS IN VETERINARY SCIENCE, Vol. 8.

By: N. Olby n & A. Tipold*

author keywords: intervertebral disc disease; canine; spinal cord injury; disc extrusion; disc degeneration
Sources: Web Of Science, NC State University Libraries
Added: April 5, 2021

2021 journal article

Effect of Sedation on the Neurological Examination of the Patellar and Withdrawal Reflexes in Healthy Dogs

FRONTIERS IN VETERINARY SCIENCE, 8.

By: K. Horsley*, N. Olby n, M. Mitchell*, K. Aulakh* & J. Gines*

author keywords: sedation; withdrawal reflex; dexmedetomidine; patellar reflex; neurological exam
TL;DR: Sedation does not affect the evaluation of the withdrawal reflex on any limb but improves the visualization of the patellar reflex in this group of neurologically normal dogs. (via Semantic Scholar)
Sources: Web Of Science, NC State University Libraries
Added: June 10, 2021

2021 journal article

Levetiracetam-responsive paroxysmal exertional dyskinesia in a Welsh Terrier

JOURNAL OF VETERINARY INTERNAL MEDICINE, 35(2), 1093–1097.

By: S. Green* & N. Olby n

author keywords: movement disorder; paroxysmal dyskinesia; treatment; Welsh Terrier
MeSH headings : Animals; Anticonvulsants / therapeutic use; Chorea / veterinary; Diazepam / therapeutic use; Dog Diseases / drug therapy; Dogs; Dystonic Disorders / veterinary; Female; Levetiracetam / therapeutic use
TL;DR: Although the pathophysiology of PED is not fully understood, the clinical presentation and the positive response to antiepileptic therapy highlight the overlap between disease pathways in epilepsy and PED in dogs. (via Semantic Scholar)
Sources: Web Of Science, NC State University Libraries, ORCID
Added: March 15, 2021

2021 journal article

Outcomes and prognostic indicators in 59 paraplegic medium to large breed dogs with extensive epidural hemorrhage secondary to thoracolumbar disc extrusion

VETERINARY SURGERY, 50(3), 527–536.

By: C. Woelfel n, J. Robertson n, C. Mariani n, K. Munana n, P. Early n & N. Olby n

MeSH headings : Animals; Cohort Studies; Dog Diseases / diagnosis; Dog Diseases / surgery; Dogs; Female; Hematoma, Epidural, Spinal / complications; Hematoma, Epidural, Spinal / surgery; Hematoma, Epidural, Spinal / veterinary; Intervertebral Disc Degeneration / complications; Intervertebral Disc Degeneration / surgery; Intervertebral Disc Degeneration / veterinary; Laminectomy / statistics & numerical data; Laminectomy / veterinary; Male; Paraplegia / diagnosis; Paraplegia / surgery; Paraplegia / veterinary; Prognosis; Recovery of Function; Retrospective Studies; Species Specificity; Treatment Outcome; Walking
TL;DR: Paraplegic medium to large breed dogs with DEEH have a less favorable outcome after surgical decompression than paraplegic dogs with TL-IVDE, and loss of pain perception and increased HASTEi are associated with a poor outcome, while more extensive decompression improves outcome. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (Web of Science; OpenAlex)
Sources: Web Of Science, NC State University Libraries
Added: March 8, 2021

2021 journal article

Plasma Amyloid Beta Concentrations in Aged and Cognitively Impaired Pet Dogs

MOLECULAR NEUROBIOLOGY, 58(2), 483–489.

By: W. Panek n, D. Murdoch*, M. Gruen n, F. Mowat n, R. Marek* & N. Olby n

Contributors: W. Panek n, D. Murdoch*, M. Gruen n, F. Mowat n, R. Marek* & N. Olby n

author keywords: Canine; Cognitive dysfunction; Alzheimer's disease; CDS; Amyloid beta 42; Amyloid beta 40
MeSH headings : Aging / blood; Amyloid beta-Peptides / blood; Animals; Cognitive Dysfunction / blood; Dogs / blood; Female; Male; Pets / blood
TL;DR: The findings suggest the dynamics of canine plasma amyloid concentrations are analogous to that found in aging humans with and without AD. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Sources: Web Of Science, ORCID, NC State University Libraries
Added: October 12, 2020

2021 article

Subaxial cervical articular process subluxation and dislocation: Cervical locked facet injuries in dogs

Woelfel, C. W., Bray, K. Y., Early, P. J., Mariani, C. L., & Olby, N. J. (2021, November 24). VETERINARY SURGERY, Vol. 11.

By: C. Woelfel n, K. Bray*, P. Early n, C. Mariani n & N. Olby n

MeSH headings : Animals; Cervical Vertebrae; Dogs; Joint Dislocations / veterinary; Neck; Retrospective Studies
TL;DR: In these dogs, locked facet injuries affected the caudal cervical vertebrae in small breeds and could be identified on imaging through the presence of dorsal displacement of a cranial articular process. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (Web of Science; OpenAlex)
Sources: Web Of Science, NC State University Libraries
Added: December 6, 2021

2021 journal article

Sustained Gaze Is a Reliable In-home Test of Attention for Aging Pet Dogs

FRONTIERS IN VETERINARY SCIENCE, 8.

By: J. Hoel n, G. Templeton n, G. Fefer n, B. Case n, A. Shah n, M. Gruen n, N. Olby n

author keywords: Canine Cognitive Dysfunction Syndrome; cognitive testing; dementia; executive function; attention; cognitive impairment
TL;DR: It is concluded that owners can perform the sustained gaze test at home and that data generated are reliable and correlate to CADES, a validated measure of dementia. (via Semantic Scholar)
Sources: Web Of Science, NC State University Libraries
Added: January 24, 2022

2021 article

Vascular endothelial growth factor concentrations in the cerebrospinal fluid of dogs with neoplastic or inflammatory central nervous system disorders

Mariani, C. L., Niman, Z. E., Boozer, L. B., Ruterbories, L. K., Early, P. J., Munana, K. R., & Olby, N. J. (2021, June 9). JOURNAL OF VETERINARY INTERNAL MEDICINE, Vol. 6.

By: C. Mariani n, Z. Niman n, L. Boozer n, L. Ruterbories n, P. Early n, K. Munana n, N. Olby n

author keywords: biomarker; brain tumor; meningoencephalitis; meningomyelitis
MeSH headings : Animals; Case-Control Studies; Central Nervous System Diseases / veterinary; Cerebrospinal Fluid; Dog Diseases; Dogs; Hospitals, Animal; Hospitals, Teaching; Vascular Endothelial Growth Factor A
TL;DR: Concentrations of VEGF in CSF are higher in dogs with central nervous system (CNS) neoplasia compared to those with meningoencephalomyelitis and other neurologic disorders and may serve as a marker of neoplastic and inflammatory CNS disorders relative to other conditions. (via Semantic Scholar)
Sources: Web Of Science, NC State University Libraries, ORCID
Added: June 10, 2021

2020 journal article

A mutation in MTM1 causes X-Linked myotubular myopathy in Boykin spaniels

Neuromuscular Disorders, 30(5), 353–359.

By: N. Olby n, S. Friedenberg*, K. Meurs n, D. DeProspero n, J. Guevar n, J. Lau n, O. Yost n, L. Guo*, G. Shelton*

author keywords: Canine; Centronuclear myopathy; Myotubularin myopathy
MeSH headings : Animals; Dogs; Male; Myopathies, Structural, Congenital / genetics; Myopathies, Structural, Congenital / pathology; Myopathies, Structural, Congenital / physiopathology; Pedigree; Phenotype; Protein Tyrosine Phosphatases, Non-Receptor / genetics
TL;DR: The purpose of this study was to report the findings of clinical and genetic evaluation of a 3-month old male Boykin spaniel that presented with progressive weakness that causes a severe form of X-linked myotubular myopathy, comparable to the human counterpart. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Sources: Web Of Science, NC State University Libraries, Crossref, ORCID
Added: June 29, 2020

2020 review

Ambulation in Dogs With Absent Pain Perception After Acute Thoracolumbar Spinal Cord Injury

[Review of ]. FRONTIERS IN VETERINARY SCIENCE, 7.

By: M. Lewis*, N. Jeffery* & N. Olby n

author keywords: spinal walking; deep pain negative; intervertebral disc herniation; canine; locomotion; gait generation
TL;DR: Improved understanding of the mechanisms of gait generation and plasticity of the surviving tissue after injury might pave the way for further treatment options and enhanced outcomes in severely injured dogs. (via Semantic Scholar)
Sources: Web Of Science, NC State University Libraries
Added: October 19, 2020

2020 journal article

An update on hemilaminectomy of the cranial thoracic spine: review of 6 Cases

Open Veterinary Journal, 10(1), 16–21.

By: K. Bray, P. Early, N. Olby & M. Lewis

Source: NC State University Libraries
Added: September 20, 2020

2020 journal article

Association between anesthesia duration and outcome in dogs with surgically treated acute severe spinal cord injury caused by thoracolumbar intervertebral disk herniation

Journal of Veterinary Internal Medicine.

By: J. Fenn*, H. Ru n, N. Jeffery*, S. Moore*, A. Tipold*, F. Soebbeler*, A. Wang‐Leandro*, C. Mariani n ...

author keywords: canine; extrusion; hemilaminectomy; prognosis; surgery
MeSH headings : Anesthesia / adverse effects; Anesthesia / veterinary; Animals; Cohort Studies; Dog Diseases / surgery; Dogs; Female; Intervertebral Disc Degeneration / veterinary; Intervertebral Disc Displacement / veterinary; Laminectomy / veterinary; Male; Operative Time; Pain / veterinary; Paraplegia / rehabilitation; Paraplegia / surgery; Paraplegia / veterinary; Retrospective Studies; Spinal Cord Injuries / surgery; Spinal Cord Injuries / veterinary; Treatment Outcome; Walking
TL;DR: A negative association between increased duration of anesthesia and outcome in dogs with absent pain perception treated surgically for acute thoracolumbar intervertebral disk herniation is supported. (via Semantic Scholar)
UN Sustainable Development Goal Categories
1. No Poverty (OpenAlex)
Sources: Crossref, NC State University Libraries, ORCID
Added: May 18, 2020

2020 review

Bladder and Bowel Management in Dogs With Spinal Cord Injury

[Review of ]. FRONTIERS IN VETERINARY SCIENCE, 7.

By: N. Granger*, N. Olby n & Y. Nout-Lomas*

author keywords: bladder; urinary and fecal incontinence; spinal cord injury; autonomic; dysfunction; canine; dog; sacral implant
TL;DR: The physiology of micturition and defecation in dogs is proposed to briefly remind the reader and the bladder and gastrointestinal clinical signs associated with sacral lesions and supra-sacral lesions are presented, largely in the context of intervertebral disc herniation. (via Semantic Scholar)
Sources: Web Of Science, NC State University Libraries
Added: December 11, 2020

2020 journal article

Cerebrospinal fluid lactate concentrations in dogs with seizure disorders

Journal of Veterinary Internal Medicine.

By: C. Mariani n, C. Nye n, L. Ruterbories n, D. Tokarz n, L. Green n, J. Lau n, N. Zidan n, P. Early n ...

author keywords: acute repetitive seizures; biomarker; cluster seizures; epilepsy; status epilepticus
MeSH headings : Animals; Dog Diseases; Dogs; Epilepsy / veterinary; Humans; Lactic Acid; Seizures / veterinary; Status Epilepticus / veterinary
TL;DR: Cerebrospinal fluid lactate concentration is minimally affected by seizure activity in dogs and increased concentrations are more likely associated with the underlying disease process. (via Semantic Scholar)
UN Sustainable Development Goal Categories
2. Zero Hunger (Web of Science)
3. Good Health and Well-being (Web of Science; OpenAlex)
Source: ORCID
Added: November 3, 2020

2020 review

Classification of Intervertebral Disc Disease

[Review of ]. FRONTIERS IN VETERINARY SCIENCE, 7.

By: J. Fenn* & N. Olby n

author keywords: IVD; chondrodystrophy; degeneration; Hansen; extrusion; protrusion
TL;DR: An up to date overview of both historical and current systems of IVDD classification is provided, highlighting the important findings and controversies underpinning them. (via Semantic Scholar)
Sources: Web Of Science, NC State University Libraries
Added: November 9, 2020

2020 review

Clinical Trial Design-A Review-With Emphasis on Acute Intervertebral Disc Herniation

[Review of ]. FRONTIERS IN VETERINARY SCIENCE, 7.

By: N. Jeffery*, N. Olby n & S. Moore*

author keywords: explanatory; pragmatic; durotomy; glyburide; spinal cord injury
TL;DR: In this review another key trial design decision—that between pragmatic and explanatory approaches—is highlighted and used as a theme to illustrate the close relationship between trial objective and design. (via Semantic Scholar)
Sources: Web Of Science, NC State University Libraries
Added: October 12, 2020

2020 journal article

Comparison of Gait Assessment Scales in Dogs with Spinal Cord Injury due to Intervertebral Disc Herniation

Journal of Neurotrauma, 1.

By: N. Olby n, E. Griffith n & J. Levine*

author keywords: intervertebral disc herniation; outcome measure; paralysis; reliability
MeSH headings : Animals; Dogs; Gait / physiology; Gait Analysis / methods; Gait Analysis / standards; Intervertebral Disc Displacement / complications; Intervertebral Disc Displacement / physiopathology; Intervertebral Disc Displacement / therapy; Physical Therapy Modalities; Spinal Cord Injuries / etiology; Spinal Cord Injuries / physiopathology; Spinal Cord Injuries / therapy; Walking / physiology
TL;DR: It is concluded that gait in dogs with SCI can be scored reliably following training and a variety of different gait scales can be used in multicenter trials to capture outcome in different ways. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Sources: Crossref, NC State University Libraries
Added: July 7, 2020

2020 review

Current Approaches to the Management of Acute Thoracolumbar Disc Extrusion in Dogs

[Review of ]. FRONTIERS IN VETERINARY SCIENCE, 7.

By: S. Moore*, A. Tipold*, N. Olby n, V. Stein* & N. Granger*

author keywords: dog; interveterbral disc; intervertebral disc disease; hemilaminectomy; spinal cord injury; hansen type I
TL;DR: There is no evidence to support treatment of the 48 h time point as a cut off beyond which it becomes impossible for dogs to achieve locomotor recovery, and recommendations for standard care can be made in some areas, particularly with respect to surgical decompression. (via Semantic Scholar)
Sources: Web Of Science, NC State University Libraries
Added: October 26, 2020

2020 journal article

Influence of Duration of Injury on Diffusion Tensor Imaging in Acute Canine Spinal Cord Injury

JOURNAL OF NEUROTRAUMA, 37(21), 2261–2267.

By: M. Lewis*, P. Early n, C. Mariani n, K. Munana n & N. Olby n

author keywords: dog; fractional anisotropy; imaging biomarker; intervertebral disc herniation; mean diffusivity
MeSH headings : Animals; Diffusion Tensor Imaging / methods; Dogs; Intervertebral Disc Displacement / diagnostic imaging; Intervertebral Disc Displacement / pathology; Intervertebral Disc Displacement / veterinary; Spinal Cord Injuries / diagnostic imaging; Spinal Cord Injuries / pathology; Spinal Cord Injuries / veterinary; Time Factors
TL;DR: Investigating the impact of duration of injury on DTI indices in dogs with acute, spontaneous SCI due to thoracolumbar intervertebral disc herniation and explore associations with clinical severity found MD might differentiate injury severity in the acute setting and be worthy of development as an imaging biomarker. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (Web of Science; OpenAlex)
Sources: Web Of Science, NC State University Libraries
Added: August 31, 2020

2020 journal article

Intervertebral disc disease and aortic thromboembolism are the most common causes of acute paralysis in dogs and cats presenting to an emergency clinic

VETERINARY RECORD, 187(10).

By: G. Rossi n, A. Stachel n, A. Lynch n & N. Olby n

MeSH headings : Animals; Cat Diseases / epidemiology; Cats; Dog Diseases / epidemiology; Dogs; Emergency Service, Hospital; Female; Intervertebral Disc Degeneration / epidemiology; Intervertebral Disc Degeneration / veterinary; Intervertebral Disc Displacement / epidemiology; Intervertebral Disc Displacement / veterinary; Male; North Carolina / epidemiology; Paralysis / etiology; Paralysis / veterinary; Prevalence; Records / veterinary; Thromboembolism / epidemiology; Thromboembolism / veterinary
TL;DR: IVDD and ATE are the overwhelming causes of acute paralysis in dogs and cats, respectively, with approximately 28% of dogs and 40 per cent of cats having a different diagnosis. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Sources: Web Of Science, NC State University Libraries, ORCID
Added: February 15, 2021

2020 journal article

Long-term postoperative pain evaluation in dogs with thoracolumbar intervertebral disk herniation after hemilaminectomy

JOURNAL OF VETERINARY INTERNAL MEDICINE, 34(4), 1547–1555.

By: N. Zidan n, J. Medland n & N. Olby n

author keywords: algometry; mechanical thresholds; neuropathic pain; postoperative pain; spinal cord injury
MeSH headings : Animals; Dog Diseases / surgery; Dogs; Female; Intervertebral Disc Degeneration / surgery; Intervertebral Disc Displacement / surgery; Laminectomy / adverse effects; Laminectomy / veterinary; Male; Neuralgia / veterinary; Pain Measurement / veterinary; Pain, Postoperative / veterinary; Prospective Studies; Sensory Thresholds; Spinal Cord Injuries / surgery; Spinal Cord Injuries / veterinary
TL;DR: Improving long‐term pain assessment of SCI dogs is important for offering treatment options and advising owners, and Mechanical sensory thresholds normalize by 6 months after surgery in most dogs with SCI. (via Semantic Scholar)
Sources: Web Of Science, NC State University Libraries, ORCID
Added: June 29, 2020

2020 journal article

Minimally invasive microsurgical decompression of an intervertebral disc protrusion in a dog

VETERINARY SURGERY, 49, O86–O92.

By: J. Guevar* & N. Olby n

MeSH headings : Animals; Decompression, Surgical / methods; Decompression, Surgical / veterinary; Dogs; Intervertebral Disc / pathology; Intervertebral Disc / surgery; Intervertebral Disc Degeneration / surgery; Intervertebral Disc Degeneration / veterinary; Intervertebral Disc Displacement / surgery; Intervertebral Disc Displacement / veterinary; Male; Microsurgery / veterinary; Neurosurgical Procedures / methods; Neurosurgical Procedures / veterinary; Retrospective Studies; Spinal Cord Compression / surgery; Spinal Cord Compression / veterinary; Treatment Outcome
TL;DR: This case provides evidence that minimally invasive microsurgery is an effective treatment for intervertebral disc protrusion in large breed dogs and may offer benefits regarding postoperative pain and functional recovery. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Sources: Web Of Science, NC State University Libraries, ORCID
Added: June 22, 2020

2020 journal article

Minimally invasive spine surgery in dogs: Evaluation of the safety and feasibility of a thoracolumbar approach to the spinal cord

Veterinary Surgery, 49, O76–O85.

By: J. Guevar n, N. Zidan n, A. Durand* & N. Olby n

MeSH headings : Animals; Dogs / surgery; Feasibility Studies; Female; Male; Minimally Invasive Surgical Procedures / methods; Minimally Invasive Surgical Procedures / veterinary; Orthopedic Procedures / veterinary; Pain, Postoperative / veterinary; Prospective Studies; Plastic Surgery Procedures; Spinal Cord / surgery; Thoracic Vertebrae / surgery; Treatment Outcome
TL;DR: Minimally invasive spine surgery was a safe and feasible technique to access the thoracolumbar vertebral canal and the ventral aspect of the spinal cord in dogs and supported postoperative pain benefits. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Sources: Web Of Science, NC State University Libraries, Crossref
Added: February 17, 2020

2020 journal article

Plasma Neurofilament Light Chain as a Translational Biomarker of Aging and Neurodegeneration in Dogs

MOLECULAR NEUROBIOLOGY, 57(7), 3143–3149.

By: W. Panek n, M. Gruen n, D. Murdoch*, R. Marek*, A. Stachel n, F. Mowat*, K. Saker n, N. Olby n

Contributors: W. Panek n, M. Gruen n, D. Murdoch*, R. Marek*, A. Stachel n, F. Mowat*, K. Saker n, N. Olby n

author keywords: Canine; Cognitive dysfunction; Alzheimer's disease; Amyotrophic lateral sclerosis; Degenerative myelopathy
TL;DR: This work identified plasma NfL as a key clinical index of neuro-aging and neurodegeneration in pet dogs using an ultrasensitive single-molecule array assay to measure plasma concentrations and found it increases in an age-dependent manner and is significantly elevated in dogs diagnosed with Neurodegenerative disease. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Sources: Web Of Science, NC State University Libraries, ORCID
Added: July 13, 2020

2020 review

Prognostic Factors in Canine Acute Intervertebral Disc Disease

[Review of ]. FRONTIERS IN VETERINARY SCIENCE, 7.

By: N. Olby n, R. Costa*, J. Levine* & V. Stein*

author keywords: paraplegia; ambulation; dog; pain perception; spinal cord injury; acute intervertebral disc extrusion; acute non-compressive nucleus pulposus extrusion
TL;DR: Cross-sectional area and length of T2 hyperintensity and loss of HASTE signal on MRI have been associated with outcome and future developments in plasma and imaging biomarkers will assist in accurate prognostication and optimization of patient management. (via Semantic Scholar)
Sources: Web Of Science, NC State University Libraries
Added: January 4, 2021

2020 journal article

Traumatic skull fractures in dogs and cats: A comparative analysis of neurological and computed tomographic features

JOURNAL OF VETERINARY INTERNAL MEDICINE, 34(5), 1975–1985.

By: P. Amengual-Batle*, R. Jose-Lopez*, A. Durand n, M. Czopowicz*, E. Beltran*, J. Guevar n, K. Lazzerini*, S. De Decker* ...

author keywords: canine; computed tomography; feline; skull fractures
MeSH headings : Animals; Cat Diseases / diagnostic imaging; Cats; Dog Diseases / diagnostic imaging; Dogs; Retrospective Studies; Skull / diagnostic imaging; Skull Fractures / diagnostic imaging; Skull Fractures / veterinary; Tomography, X-Ray Computed / veterinary
TL;DR: The cranial vault fractures were associated with neurological deficits and worse survival, and the presence of TSF alone should not be considered a negative prognostic factor because most affected animals survived the first week. (via Semantic Scholar)
Sources: Web Of Science, NC State University Libraries
Added: August 3, 2020

2019 journal article

A QIL1 Variant Associated with Ventricular Arrhythmias and Sudden Cardiac Death in the Juvenile Rhodesian Ridgeback Dog

Genes, 10(2), 168.

By: K. Meurs n, S. Friedenberg*, N. Olby n, J. Condit n, J. Weidman*, S. Rosenthal*, G. Shelton*

author keywords: QIL1; Rhodesian ridgeback; arrhythmia; mitochondrial cristae
MeSH headings : Animals; Death, Sudden, Cardiac / veterinary; Dog Diseases / genetics; Dog Diseases / pathology; Dogs; Female; Male; Mitochondria, Muscle / metabolism; Mitochondria, Muscle / ultrastructure; Mitochondrial Proteins / genetics; Mutation; Tachycardia, Ventricular / genetics; Tachycardia, Ventricular / pathology; Tachycardia, Ventricular / veterinary
TL;DR: A natural animal model of mitochondrial cardiomyopathy provides a large animal model with which to study the development and progression of disease as well as genotypic phenotypic relationships. (via Semantic Scholar)
UN Sustainable Development Goal Categories
7. Affordable and Clean Energy (OpenAlex)
Sources: Web Of Science, NC State University Libraries, Crossref, ORCID
Added: March 25, 2019

2019 journal article

A missense variant in the titin gene in Doberman pinscher dogs with familial dilated cardiomyopathy and sudden cardiac death

Human Genetics, 138(5), 515–524.

By: K. Meurs n, S. Friedenberg*, J. Kolb*, C. Saripalli*, P. Tonino*, K. Woodruff n, N. Olby n, B. Keene n ...

MeSH headings : Amino Acid Sequence; Animals; Base Sequence; Cardiomyopathy, Dilated / genetics; Cardiomyopathy, Dilated / veterinary; Connectin / genetics; Death, Sudden, Cardiac / etiology; Death, Sudden, Cardiac / veterinary; Disease Models, Animal; Dogs; Female; Genetic Predisposition to Disease / genetics; Male; Mutation, Missense / genetics; Protein Kinases / genetics; Whole Genome Sequencing
TL;DR: The dog provides a large animal model of familial dilated cardiomyopathy and is an excellent model to improve the understanding of the genotypic phenotypic relationships, penetrance, expression and the pathophysiology of variants in the titin gene. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Sources: Web Of Science, NC State University Libraries, Crossref
Added: June 17, 2019

2019 journal article

Cerebrospinal fluid lactate in dogs with inflammatory central nervous system disorders

Journal of Veterinary Internal Medicine, 33(6), 2701–2708.

By: C. Mariani n, C. Nye n, D. Tokarz n, L. Green n, J. Lau n, N. Zidan n, P. Early n, J. Guevar n ...

author keywords: canine; encephalitis; meningitis; meningo; meningoencephalitis; myelitis
MeSH headings : Animals; Dog Diseases / cerebrospinal fluid; Dogs; Inflammation / cerebrospinal fluid; Inflammation / veterinary; Lactic Acid / cerebrospinal fluid; Meningoencephalitis / cerebrospinal fluid; Meningoencephalitis / drug therapy; Meningoencephalitis / pathology; Meningoencephalitis / veterinary; Reference Values; Retrospective Studies; Steroids / therapeutic use
TL;DR: Cerebrospinal fluid lactate concentrations could serve as a rapid biomarker of inflammatory CNS disease in dogs as well as humans with inflammatory central nervous system disorders. (via Semantic Scholar)
Sources: Crossref, NC State University Libraries, ORCID
Added: September 25, 2019

2019 journal article

Clinical characteristics, breed differences, and quality of life in North American dogs with acute steroid‐responsive meningitis‐arteritis

Journal of Veterinary Internal Medicine, 33(4), 1719–1727.

By: J. Lau n, J. Nettifee n, P. Early n, C. Mariani n, N. Olby n & K. Muñana n

author keywords: aseptic meningitis; CSF analysis; immune-mediated disease; treatment response
MeSH headings : Animals; Arteritis / cerebrospinal fluid; Arteritis / drug therapy; Arteritis / veterinary; Canada / epidemiology; Dog Diseases / cerebrospinal fluid; Dog Diseases / drug therapy; Dog Diseases / pathology; Dogs; Female; Genetic Predisposition to Disease; Male; Meningitis / cerebrospinal fluid; Meningitis / drug therapy; Meningitis / veterinary; Neutrophils; Quality of Life; Recurrence; Retrospective Studies; Steroids / administration & dosage; Steroids / adverse effects; Steroids / therapeutic use; Surveys and Questionnaires; United States / epidemiology
TL;DR: Golden Retrievers and Wirehaired Pointing Griffons should be considered among the breeds recognized to develop SRMA, and treatment with higher corticosteroid dosages is correlated with more severe adverse effects and worse QoL. (via Semantic Scholar)
Sources: Crossref, NC State University Libraries, ORCID
Added: June 8, 2019

2019 journal article

Co-infection with Bartonella henselae and Sarcocystis sp. in a 6-year-old male neutered domestic longhair cat with progressive multifocal neurological signs

Veterinary Quarterly, 39(1), 168–173.

MeSH headings : Animals; Bartonella henselae / genetics; Bartonella henselae / isolation & purification; Cat Diseases / drug therapy; Cat Diseases / microbiology; Cat-Scratch Disease / diagnosis; Cat-Scratch Disease / drug therapy; Cats; Coinfection / microbiology; Databases, Nucleic Acid; Drug Therapy, Combination / veterinary; Male; Orchiectomy / veterinary; Sarcocystis / genetics; Sarcocystis / isolation & purification; Sarcocystosis / diagnosis; Sarcocystosis / drug therapy; Treatment Outcome
TL;DR: Aude Castel, Natasha J. Olby, Edward B. Breitschwerdt, Brittany Thomas, Ricardo G. Maggi and G. Diane Shelton present a novel approach to cell reprograming that allows for real-time characterization of the “silent” and “active” components of E.coli. (via Semantic Scholar)
Sources: Crossref, NC State University Libraries
Added: July 7, 2020

2019 journal article

Comparison of cerebrospinal fluid parameters from the cerebellomedullary and lumbar cisterns in 54 dogs

Canadian Veterinary Journal, 60(8), 885–888.

By: P. Early, K. Munana, N. Olby & C. Mariani

Source: NC State University Libraries
Added: September 20, 2020

2019 journal article

Development of a Novel Gait Analysis Tool Measuring Center of Pressure for Evaluation of Canine Chronic Thoracolumbar Spinal Cord Injury

Journal of Neurotrauma, 36(21), 3018–3025.

By: M. Lewis*, K. Williams*, T. Langley*, L. Jarvis*, G. Sawicki* & N. Olby n

author keywords: center of pressure; chronic spinal cord injury; dogs; locomotion; postural control
MeSH headings : Animals; Dogs; Gait Analysis / instrumentation; Lumbar Vertebrae; Postural Balance / physiology; Spinal Cord Injuries / veterinary; Thoracic Vertebrae
TL;DR: COP analysis and body weight support measurements offer information about post-injury locomotion and further development is needed before consideration as an outcome measure to complement validated gait analysis methods in dogs with SCI. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (Web of Science; OpenAlex)
Sources: Web Of Science, NC State University Libraries, Crossref
Added: June 24, 2019

2019 journal article

Genome-wide association analysis in West Highland White Terriers with atopic dermatitis

Veterinary Immunology and Immunopathology, 209, 1–6.

By: C. Agler n, S. Friedenberg*, T. Olivry n, K. Meurs n & N. Olby n

Contributors: C. Agler n, S. Friedenberg*, T. Olivry n, K. Meurs n & N. Olby n

author keywords: Allergy; Atopic; Canine; Dogs; Genetics; GWAS; Skin
MeSH headings : Animals; Cohort Studies; Dermatitis, Atopic / genetics; Dermatitis, Atopic / veterinary; Dog Diseases / genetics; Dogs; Female; Genome-Wide Association Study / veterinary; Genotyping Techniques / veterinary; Male; Polymorphism, Single Nucleotide
TL;DR: Atopic dermatitis in WHWT is associated with a region on CFA3 that contains several candidate genes and a homozygous variant in the F2R gene present in multiple breeds that also suffer from AD warrants further evaluation. (via Semantic Scholar)
UN Sustainable Development Goal Categories
15. Life on Land (OpenAlex)
Sources: Web Of Science, NC State University Libraries, ORCID, Crossref
Added: April 15, 2019

2019 journal article

Morphometric analysis of spinal cord termination in Cavalier King Charles Spaniels

Journal of Veterinary Internal Medicine, 33(2), 717–725.

By: C. Sparks n, I. Robertson n & N. Olby n

author keywords: conus medullaris; dural sac; filum terminate; syringomyelia
MeSH headings : Animals; Dog Diseases / diagnostic imaging; Dogs; Dura Mater / abnormalities; Female; Magnetic Resonance Imaging / veterinary; Male; Neural Tube Defects / diagnostic imaging; Neural Tube Defects / veterinary; Reproducibility of Results; Retrospective Studies; Spinal Cord / abnormalities; Syringomyelia / diagnostic imaging; Syringomyelia / veterinary
TL;DR: The relationship between TL SM and possible spinal cord tethering because of a more caudal dural sac termination should be investigated. (via Semantic Scholar)
Sources: Web Of Science, NC State University Libraries, Crossref, ORCID
Added: April 22, 2019

2019 journal article

Predictors of Response to 4-Aminopyridine in Chronic Canine Spinal Cord Injury

Journal of Neurotrauma, 36(9), 1428–1434.

By: M. Lewis*, E. Laber n & N. Olby n

author keywords: canine; chronic SCI; motor neuron pool excitability; potassium channel antagonist; spasticity
MeSH headings : 4-Aminopyridine / pharmacology; Animals; Dogs; Evoked Potentials, Motor / physiology; Female; H-Reflex / physiology; Male; Motor Neurons / physiology; Muscle Spasticity / physiopathology; Potassium Channel Blockers / pharmacology; Spinal Cord Injuries / physiopathology
TL;DR: Comparing clinical, electrodiagnostic, gait, and imaging variables between dogs that do and do not respond to 4AP, to identify predictors of response suggested Severity of spasticity and H-reflex threshold might allow prediction of response. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (Web of Science; OpenAlex)
Sources: Web Of Science, Crossref, NC State University Libraries
Added: December 31, 2018

2019 journal article

Presence of cerebrospinal fluid antibodies associated with autoimmune encephalitis of humans in dogs with neurologic disease

Journal of Veterinary Internal Medicine, 33(5), 2175–2182.

By: E. Stafford n, A. Kortum n, A. Castel n, L. Green n, J. Lau n, P. Early n, K. Muñana n, C. Mariani n, J. Yoder n, N. Olby n

author keywords: immunofluorescent assay; meningoencephalitis; MUE; NMDA receptor encephalitis
MeSH headings : Animals; Autoantibodies / cerebrospinal fluid; Central Nervous System Diseases / cerebrospinal fluid; Central Nervous System Diseases / immunology; Central Nervous System Diseases / veterinary; Dog Diseases / cerebrospinal fluid; Dog Diseases / immunology; Dogs; Female; Fluorescent Antibody Technique, Indirect / veterinary; Humans; Male; Meningoencephalitis / cerebrospinal fluid; Meningoencephalitis / immunology; Meningoencephalitis / therapy; Neurons / immunology; Receptors, N-Methyl-D-Aspartate / immunology
TL;DR: Defining antigenic targets associated with encephalitis in dogs might allow diagnostic categorization of MUE antemortem and further evaluation of the prevalence and clinical relevance of CSF and serum antibodies to neuronal cell surface antigens is warranted. (via Semantic Scholar)
Sources: Crossref, NC State University Libraries, ORCID
Added: September 9, 2019

2019 journal article

Risk factors associated with progressive myelomalacia in dogs with complete sensorimotor loss following intervertebral disc extrusion: a retrospective case-control study

BMC Veterinary Research, 15(1).

By: A. Castel*, N. Olby n, H. Ru n, C. Mariani n, K. Muñana n & P. Early n

author keywords: Ascending-descending myelomalacia; Spinal cord injury; Intervertebral disk disease; Paraplegia
MeSH headings : Animals; Case-Control Studies; Dog Diseases / etiology; Dog Diseases / pathology; Dog Diseases / physiopathology; Dogs; Female; Intervertebral Disc Displacement / complications; Intervertebral Disc Displacement / veterinary; Logistic Models; Male; Multivariate Analysis; Paraplegia / etiology; Paraplegia / physiopathology; Paraplegia / veterinary; Retrospective Studies; Risk Factors; Spinal Cord Diseases / etiology; Spinal Cord Diseases / pathology; Spinal Cord Diseases / physiopathology; Spinal Cord Diseases / veterinary
TL;DR: Dogs with lumbar intumescence IVDE are at increased risk of progressive myelomalacia and timing of surgery and corticosteroid use warrant further investigations. (via Semantic Scholar)
Sources: Web Of Science, NC State University Libraries, Crossref, ORCID
Added: February 10, 2020

2019 journal article

The R9H phospholamban mutation is associated with highly penetrant dilated cardiomyopathy and sudden death in a spontaneous canine model

Gene, 697, 118–122.

By: O. Yost n, S. Friedenberg*, S. Jesty, N. Olby n & K. Meurs n

author keywords: Canine; Phospholamban; Dilated cardiomyopathy; Sudden death; Genetic
MeSH headings : Animals; Calcium-Binding Proteins / genetics; Calcium-Binding Proteins / physiology; Cardiomyopathy, Dilated / genetics; Death, Sudden / etiology; Death, Sudden / veterinary; Dogs; Female; Genetic Predisposition to Disease / genetics; Male; Mutation / genetics; Pedigree; Polymorphism, Single Nucleotide / genetics; Sequence Analysis, DNA
TL;DR: A spontaneous canine model of familial DCM and sudden death with the R9H mutation is described, which was highly penetrant and resulted in sudden death in comparison to a reported human family. (via Semantic Scholar)
Sources: Crossref, NC State University Libraries
Added: September 29, 2019

2019 journal article

Time course and prognostic value of serum GFAP, pNFH, and S100β concentrations in dogs with complete spinal cord injury because of intervertebral disc extrusion

Journal of Veterinary Internal Medicine, 33(2), 726–734.

By: N. Olby n, J. Lim*, N. Wagner*, N. Zidan n, P. Early n, C. Mariani n, K. Muñana n, E. Laber n

author keywords: biomarker; intervertebral disc disease; myelomalacia; prognosis
MeSH headings : Animals; Biomarkers / blood; Dogs / blood; Dogs / injuries; Glial Fibrillary Acidic Protein / blood; Intermediate Filaments / metabolism; Intervertebral Disc Degeneration / veterinary; Intervertebral Disc Displacement / veterinary; Paralysis / blood; Paralysis / veterinary; Phosphorylation; Prognosis; Prospective Studies; S100 Calcium Binding Protein beta Subunit / blood; Spinal Cord Injuries / blood; Time Factors
TL;DR: Serum GFAP concentrations can be used to predict outcome in clinically complete SCI with an accuracy of 76.7%‐89% depending on sample timing. (via Semantic Scholar)
Sources: Crossref, NC State University Libraries, ORCID
Added: February 20, 2019

2018 journal article

A de novo mutation in the EXT2 gene associated with osteochondromatosis in a litter of American Staffordshire Terriers

Journal of Veterinary Internal Medicine, 32(3), 986–992.

author keywords: bone; cartilage; genetics; multiple cartilaginous exostoses; mutation; osteochondroma
MeSH headings : Animals; Cartilage / pathology; Dog Diseases / genetics; Dog Diseases / pathology; Dogs; Female; Genetic Variation / genetics; Male; Mosaicism / veterinary; N-Acetylglucosaminyltransferases / genetics; Osteochondromatosis / genetics; Osteochondromatosis / pathology; Osteochondromatosis / veterinary; Polymorphism, Single Nucleotide / genetics; Whole Genome Sequencing / veterinary
TL;DR: The identical mutation arose de novo in a litter of American Staffordshire Terrier puppies and represents the first reported mutation associated with osteochondromatosis in dogs. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Sources: Web Of Science, NC State University Libraries, Crossref, ORCID
Added: August 6, 2018

2018 journal article

A randomized, blinded, prospective clinical trial of postoperative rehabilitation in dogs after surgical decompression of acute thoracolumbar intervertebral disc herniation

Journal of Veterinary Internal Medicine, 32(3), 1133–1144.

By: N. Zidan n, C. Sims n, J. Fenn*, K. Williams n, E. Griffith n, P. Early n, C. Mariani n, K. Munana n ...

author keywords: ataxia; gait training; locomotion; plasticity; spinal cord injury
MeSH headings : Animals; Decompression, Surgical / methods; Decompression, Surgical / veterinary; Dog Diseases / surgery; Dogs; Female; Intervertebral Disc Displacement / rehabilitation; Intervertebral Disc Displacement / surgery; Intervertebral Disc Displacement / veterinary; Lumbar Vertebrae / surgery; Male; Postoperative Care / veterinary; Recovery of Function; Thoracic Vertebrae / surgery
TL;DR: Early postoperative rehabilitation after surgery for TL‐IVDH is safe but doesn't improve rate or level of recovery in dogs with incomplete SCI. (via Semantic Scholar)
Sources: Web Of Science, NC State University Libraries, Crossref, ORCID
Added: August 6, 2018

2018 journal article

Deafness and vestibular dysfunction in a Doberman Pinscher puppy associated with a mutation in the PTPRQ gene

Journal of Veterinary Internal Medicine, 32(2), 665–669.

By: J. Guevar n, N. Olby n, K. Meurs n, O. Yost n & S. Friedenberg*

author keywords: deafness; Doberman Pinscher; genetics; PTPRQ; vestibular disease
MeSH headings : Animals; Dog Diseases / genetics; Dogs; Female; Frameshift Mutation; Hearing Loss / genetics; Hearing Loss / veterinary; Receptor-Like Protein Tyrosine Phosphatases, Class 3 / genetics; Vestibular Diseases / genetics; Vestibular Diseases / veterinary; Whole Genome Sequencing
TL;DR: The identification of a genetic alteration on the PTPRQ gene that is associated with congenital hearing and vestibular disorder in a young Doberman Pinscher dog is reported. (via Semantic Scholar)
Sources: Web Of Science, NC State University Libraries, Crossref, ORCID
Added: August 6, 2018

2018 journal article

Development of an International Canine Spinal Cord Injury observational registry: a collaborative data-sharing network to optimize translational studies of SCI

Spinal Cord, 56(7), 656–665.

By: S. Moore*, N. Zidan n, I. Spitzbarth*, Y. Nout-Lomas*, N. Granger*, R. da Costa*, J. Levine*, N. Jeffery* ...

MeSH headings : Animals; Cohort Studies; Cross-Over Studies; Disease Models, Animal; Dogs; Europe; Female; Information Dissemination; International Cooperation; Male; Registries; Spinal Cord Injuries / epidemiology; Spinal Cord Injuries / therapy; Spinal Cord Injuries / veterinary; Translational Research, Biomedical / methods; United States
TL;DR: Analysis of data accumulated during the first year of the canine SCI registry suggests that 16% of dogs with SCI present with severe, sensorimotor-complete injury and that 15% of cases are seen by a tertiary care facility within 8 h of injury. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Sources: Web Of Science, NC State University Libraries, Crossref
Added: August 6, 2018

2018 conference paper

Investigation of Sensory Thresholds in Cavalier King Charles Spaniels with and without Chiari-like Malformations and Syringomyelia

Pain in Animals Workshop 2017: Abstracts. Presented at the Pain in Animals Workshop 2017: Abstracts.

By: C. Sparks n, A. Gorney n, K. Williams n, B. Lascelles n & N. Olby n

Event: Pain in Animals Workshop 2017: Abstracts

Sources: Crossref, NC State University Libraries
Added: January 25, 2020

2018 journal article

Investigation of sensory thresholds in Cavalier King Charles Spaniels with and without Chiari-like malformations and syringomyelia

Journal of Veterinary Internal Medicine, 32(6), 2021–2028.

By: C. Sparks n, A. Gorney n, K. Williams n, E. Griffith n, S. Cerda-Gonzalez*, B. Lascelles n, N. Olby n

author keywords: neuropathic pain; paresthesia; phantom scratch; syrinx
MeSH headings : Animals; Brain / diagnostic imaging; Brain / physiopathology; Budd-Chiari Syndrome / diagnostic imaging; Budd-Chiari Syndrome / physiopathology; Budd-Chiari Syndrome / veterinary; Case-Control Studies; Dog Diseases / diagnostic imaging; Dog Diseases / physiopathology; Dogs; Female; Hypesthesia / physiopathology; Hypesthesia / veterinary; Magnetic Resonance Imaging / veterinary; Male; Neuroimaging / veterinary; Sensory Thresholds / physiology; Syringomyelia / diagnostic imaging; Syringomyelia / physiopathology; Syringomyelia / veterinary
TL;DR: Mechanical and thermal sensitivity does not appear to be related to the presence of SM, but mechanical sensitivity appears to berelated to the existence of pain and clinical signs. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (Web of Science; OpenAlex)
Sources: Web Of Science, NC State University Libraries, Crossref, ORCID
Added: December 31, 2018

2018 journal article

Saccadic oscillations in 4 dogs and 1 cat

Journal of Veterinary Internal Medicine, 32(4), 1392–1396.

By: E. Ives, E. MacKillop & N. Olby n

author keywords: cerebellum; macrosaccadic oscillations; opsoclonus; vestibular disease
MeSH headings : Animals; Cat Diseases / diagnosis; Cat Diseases / physiopathology; Cats; Dog Diseases / diagnosis; Dog Diseases / physiopathology; Dogs; Eye Movement Measurements / veterinary; Female; Male; Neurologic Examination / veterinary; Ocular Motility Disorders / diagnosis; Ocular Motility Disorders / physiopathology; Ocular Motility Disorders / veterinary
TL;DR: The clinical histories of three dogs and one cat displaying involuntary eye movements consistent with opsoclonus are presented, with final diagnoses including idiopathic generalized tremor syndrome and neuronal ceroid lipofuscinosis (NCL). (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (Web of Science; OpenAlex)
Sources: Crossref, NC State University Libraries, ORCID
Added: September 19, 2020

2018 journal article

The Effect of Electromagnetic Fields on Post-Operative Pain and Locomotor Recovery in Dogs with Acute, Severe Thoracolumbar Intervertebral Disc Extrusion: A Randomized Placebo-Controlled, Prospective Clinical Trial

Journal of Neurotrauma, 35(15), 1726–1736.

By: N. Zidan n, J. Fenn*, E. Griffith n, P. Early n, C. Mariani n, K. Muñana n, J. Guevar n, N. Olby n

Contributors: N. Zidan n, J. Fenn*, E. Griffith n, P. Early n, C. Mariani n, K. Muñana n, J. Guevar n, N. Olby n

author keywords: biomarker; GFAP; hemilaminectomy; pain; spinal cord injury
MeSH headings : Animals; Decompression, Surgical; Dog Diseases / therapy; Dogs; Female; Intervertebral Disc Displacement / complications; Intervertebral Disc Displacement / surgery; Lumbar Vertebrae; Magnetic Field Therapy / methods; Male; Pain, Postoperative / etiology; Pain, Postoperative / therapy; Random Allocation; Recovery of Function / radiation effects; Spinal Cord Injuries / etiology; Spinal Cord Injuries / therapy; Thoracic Vertebrae
TL;DR: It is concluded that PEMF reduced incision-associated pain in dogs post-surgery for IVDE and may reduce extent of SCI and enhance proprioceptive placing. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (Web of Science; OpenAlex)
Sources: Web Of Science, Crossref, NC State University Libraries, ORCID
Added: August 6, 2018

2018 journal article

The Relationship between Lesion Severity Characterized by Diffusion Tensor Imaging and Motor Function in Chronic Canine Spinal Cord Injury

Journal of Neurotrauma, 35(3), 500–507.

By: M. Lewis n, P. Yap*, S. McCullough & N. Olby n

author keywords: chronic paralysis; fractional anisotropy; magnetic resonance imaging; mean diffusivity; tractography
MeSH headings : Animals; Diffusion Tensor Imaging; Dogs; Image Processing, Computer-Assisted; Motor Activity / physiology; Spinal Cord Injuries / veterinary
TL;DR: Findings suggest DTI quantifies injury severity and suggests motor recovery in apparently complete dogs is because of supraspinal input. (via Semantic Scholar)
Sources: Crossref, NC State University Libraries
Added: July 27, 2019

2017 journal article

Associations Between Anesthetic Variables and Functional Outcome in Dogs With Thoracolumbar Intervertebral Disk Extrusion Undergoing Decompressive Hemilaminectomy

Journal of Veterinary Internal Medicine, 31(3), 814–824.

By: J. Fenn*, E. Laber n, K. Williams n, C. Rousse n, P. Early n, C. Mariani n, K. Munana n, S. Decker* ...

Contributors: J. Fenn*, E. Laber n, K. Williams n, C. Rousse n, P. Early n, C. Mariani n, K. Muñana n, S. De Decker*, H. Volk*, N. Olby n

author keywords: Anesthesia; Canine; Intervertebral disk extrusion; Prognosis; Spinal cord injury
MeSH headings : Anesthesia, General / adverse effects; Anesthesia, General / methods; Anesthesia, General / veterinary; Animals; Bradycardia / chemically induced; Bradycardia / veterinary; Decompression, Surgical / methods; Decompression, Surgical / veterinary; Dog Diseases / surgery; Dogs; Female; Hypotension / chemically induced; Hypotension / veterinary; Intervertebral Disc Displacement / surgery; Intervertebral Disc Displacement / veterinary; Laminectomy / methods; Laminectomy / veterinary; Male; Retrospective Studies; Thoracic Vertebrae / surgery; Treatment Outcome
TL;DR: Across all outcome measures, regression tree analysis highlighted functional grade at presentation as the primary determining factor, and among pain perception negative dogs, there was a possible association between increased duration of surgery and poorer outcome. (via Semantic Scholar)
UN Sustainable Development Goal Categories
1. No Poverty (OpenAlex)
Sources: Web Of Science, Crossref, NC State University Libraries, ORCID
Added: August 6, 2018

2017 journal article

Clinical Characteristics of Dogs with Progressive Myelomalacia Following Acute Intervertebral Disc Extrusion

Journal of Veterinary Internal Medicine, 31(6), 1782–1789.

By: A. Castel n, N. Olby n, C. Mariani n, K. Muñana n & P. Early n

Contributors: A. Castel n, N. Olby n, C. Mariani n, K. Muñana n & P. Early n

author keywords: Ascending-descending myelomalacia; Intervertebral disc disease; Spinal cord injury
MeSH headings : Animals; Disease Progression; Dog Diseases / diagnostic imaging; Dog Diseases / pathology; Dogs; Female; Intervertebral Disc Degeneration / diagnostic imaging; Intervertebral Disc Degeneration / pathology; Intervertebral Disc Degeneration / veterinary; Intervertebral Disc Displacement / diagnostic imaging; Intervertebral Disc Displacement / pathology; Intervertebral Disc Displacement / veterinary; Magnetic Resonance Imaging / veterinary; Male; Myelography / veterinary; Retrospective Studies; Spinal Cord Diseases / mortality; Spinal Cord Diseases / pathology; Spinal Cord Diseases / veterinary; Tomography, X-Ray Computed / veterinary
TL;DR: The majority of dogs developed PMM within 2 days of presentation and was euthanized within another 3 days, however, onset can be delayed up to 5 days after presentation with progression to euthanasia taking as long as 2 weeks. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (Web of Science; OpenAlex)
Sources: Web Of Science, Crossref, NC State University Libraries, ORCID
Added: August 6, 2018

2017 journal article

Development of a clinical spasticity scale for evaluation of dogs with chronic thoracolumbar spinal cord injury

American Journal of Veterinary Research, 78(7), 854–861.

By: M. Lewis & N. Olby*

MeSH headings : Adult; Animals; Dogs / injuries; Gait; Hindlimb; Humans; Muscle Spasticity / diagnosis; Muscle Spasticity / physiopathology; Muscle Spasticity / veterinary; Paralysis / etiology; Paralysis / veterinary; Prospective Studies; Reproducibility of Results; Spinal Cord Injuries / diagnosis; Spinal Cord Injuries / physiopathology; Spinal Cord Injuries / veterinary
TL;DR: The CSS could be used to quantify hind limb spasticity in dogs with chronic thoracolumbar SCI and might be a useful outcome measure and Flexor spasms may represent an integral part of stepping in Dogs with severe SCI. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (Web of Science; OpenAlex)
Sources: Crossref, NC State University Libraries
Added: July 27, 2019

2017 journal article

Evaluation of gene expression and DNA copy number profiles of adipose tissue-derived stromal cells and consecutive neurosphere-like cells generated from dogs with naturally occurring spinal cord injury

American Journal of Veterinary Research, 78(3), 371–380.

By: J. Lim*, S. Koh*, R. Thomas*, M. Breen* & N. Olby*

MeSH headings : Adipose Tissue / cytology; Animals; Cells, Cultured; Comparative Genomic Hybridization; Dogs; Female; Gene Dosage / genetics; Gene Expression Profiling; Gene Expression Regulation; Male; Neural Stem Cells / cytology; Neural Stem Cells / pathology; Neurons / cytology; Neurons / pathology; Proteins / genetics; Spinal Cord Injuries / physiopathology; Spinal Cord Injuries / veterinary; Stromal Cells / cytology; Stromal Cells / physiology
TL;DR: ADSCs can potentially be a safe and clinically relevant autologous source for canine neural progenitor cells and DNA copy number stability was suggested by the methods used. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (OpenAlex)
Sources: NC State University Libraries, Crossref, NC State University Libraries
Added: August 6, 2018

2017 journal article

Genetics of Hereditary Ataxia in Scottish Terriers

Journal of Veterinary Internal Medicine, 31(4), 1132–1139.

By: G. Urkasemsin n, D. Nielsen n, A. Singleton*, S. Arepalli, D. Hernandez*, C. Agler n, N. Olby n

author keywords: Canine; Cerebellar abiotrophy; Cerebellar ataxia; Neurodegeneration
MeSH headings : Animals; Brain / diagnostic imaging; Dog Diseases / diagnostic imaging; Dog Diseases / genetics; Dogs; Female; Genetic Linkage / genetics; Genome-Wide Association Study / veterinary; Homozygote; Magnetic Resonance Imaging / veterinary; Male; Neuroimaging / veterinary; Pedigree; Spinocerebellar Degenerations / diagnostic imaging; Spinocerebellar Degenerations / genetics; Spinocerebellar Degenerations / veterinary
TL;DR: This finding suggests that further genetic investigation of the potential region of interest on CFA X should be considered in order to identify the causal mutation as well as develop a genetic test to eliminate the disease from this breed. (via Semantic Scholar)
Sources: Web Of Science, Crossref, NC State University Libraries
Added: August 6, 2018

2017 journal article

Magnetic resonance imaging features of dogs with incomplete recovery after acute, severe spinal cord injury

Spinal Cord, 56(2), 133–141.

By: M. Lewis n, E. Cohen n & N. Olby n

Contributors: M. Lewis n, E. Cohen n & N. Olby n

MeSH headings : Analysis of Variance; Animals; Dogs; Female; Image Processing, Computer-Assisted; Magnetic Resonance Imaging; Male; Recovery of Function / physiology; Spinal Cord / diagnostic imaging; Spinal Cord Injuries / diagnostic imaging; Spinal Cord Injuries / physiopathology; Spinal Cord Injuries / veterinary
TL;DR: Findings demonstrate a spectrum of injury severity on MRI among severely affected dogs, which is related to functional status. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (Web of Science; OpenAlex)
Sources: Web Of Science, ORCID, Crossref, NC State University Libraries
Added: August 6, 2018

2017 journal article

Quantifying center of pressure variability in chondrodystrophoid dogs

The Veterinary Journal, 226, 26–31.

By: S. Blau n, L. Davis n, A. Gorney n, C. Dohse n, K. Williams n, J. Lim n, W. Pfitzner n, E. Laber n, G. Sawicki n, N. Olby n

author keywords: Locomotion; Kinematics; Center of gravity
MeSH headings : Animals; Biomechanical Phenomena; Cartilage / growth & development; Dog Diseases / physiopathology; Dogs / anatomy & histology; Dogs / physiology; Gait; Species Specificity; Spinal Cord Injuries / physiopathology; Spinal Cord Injuries / veterinary
TL;DR: In conclusion, COP variability can be measured consistently in dogs, and a range of COP variability for normal chondrodystrophoid dogs has been determined to provide a baseline for future studies on dogs with spinal cord injury. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (Web of Science; OpenAlex)
Sources: Web Of Science, Crossref, NC State University Libraries
Added: August 6, 2018

2017 journal article

Questionnaire-based Analysis of Owner-reported Scratching and Pain Signs in Cavalier King Charles Spaniels Screened for Chiari-like Malformation and Syringomyelia

Journal of Veterinary Internal Medicine, 32(1), 331–339.

By: C. Sparks n, S. Cerda-Gonzalez*, E. Griffith n, B. Lascelles n & N. Olby n

author keywords: Neuropathic pain; Paresthesia; Phantom scratch; Syrinx
MeSH headings : Animals; Arnold-Chiari Malformation / diagnostic imaging; Arnold-Chiari Malformation / pathology; Arnold-Chiari Malformation / veterinary; Dog Diseases / diagnosis; Dog Diseases / diagnostic imaging; Dog Diseases / pathology; Dogs; Female; Magnetic Resonance Imaging / veterinary; Male; Neuroimaging / veterinary; Pain / pathology; Pain / veterinary; Pruritus / pathology; Pruritus / veterinary; Surveys and Questionnaires; Syringomyelia / diagnostic imaging; Syringomyelia / pathology; Syringomyelia / veterinary
TL;DR: Lack of association of owner‐reported signs with SM highlights the lack of understanding of the pathophysiology of pain in this disease. (via Semantic Scholar)
Sources: Web Of Science, ORCID, Crossref, NC State University Libraries
Added: August 6, 2018

2017 journal article

Targeting Translational Successes through CANSORT-SCI: Using Pet Dogs To Identify Effective Treatments for Spinal Cord Injury

Journal of Neurotrauma, 34(12), 2007–2018.

By: S. Moore*, N. Granger*, N. Olby n, I. Spitzbarth*, N. Jeffery*, A. Tipold*, Y. Nout-Lomas*, R. da Costa* ...

author keywords: animal model; clinical trial; dog; spinal cord injury
MeSH headings : Animals; Disease Models, Animal; Dogs; Pets; Spinal Cord Injuries; Translational Research, Biomedical
TL;DR: The high prevalence of acute, naturally occurring SCI in pet dogs provides a unique opportunity to evaluate expeditiously promising interventions in a population of animals that receive diagnoses and treatment clinically in a manner similar to persons with SCI, while adhering to National Institutes of Health guidelines for scientific rigor and transparent reporting. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Sources: Web Of Science, Crossref, NC State University Libraries
Added: August 6, 2018

2017 journal article

The Frequency and Clinical Implications of Bacteriuria in Chronically Paralyzed Dogs

Journal of Veterinary Internal Medicine, 31(6), 1790–1795.

By: S. Rafatpanah Baigi*, S. Vaden n & N. Olby n

author keywords: Canine; Incontinence; Spinal cord injury; Urinary tract infection
MeSH headings : Animals; Bacteriuria / complications; Bacteriuria / mortality; Bacteriuria / veterinary; Dog Diseases / pathology; Dogs; Female; Fever / veterinary; Male; Paraplegia / complications; Paraplegia / veterinary; Pyuria / veterinary; Retrospective Studies; Urinary Tract Infections / complications; Urinary Tract Infections / diagnosis; Urinary Tract Infections / veterinary
TL;DR: Bacteriuria is common in paralyzed dogs but does not cause fever; diagnostic criteria of UTI are unclear, and an association of bacteriuria with survival, but this needs further confirmation. (via Semantic Scholar)
Sources: Web Of Science, Crossref, NC State University Libraries, ORCID
Added: August 6, 2018

2017 journal article

The Relationship between Trans-Lesional Conduction, Motor Neuron Pool Excitability, and Motor Function in Dogs with Incomplete Recovery from Severe Spinal Cord Injury

Journal of Neurotrauma, 34(21), 2994–3002.

By: M. Lewis n, J. Howard* & N. Olby n

author keywords: central pattern generator; disc extrusion; electrophysiology; motor evoked potentials
MeSH headings : Animals; Dogs; Evoked Potentials, Motor / physiology; Evoked Potentials, Somatosensory / physiology; Gait / physiology; H-Reflex / physiology; Locomotion / physiology; Motor Neurons / physiology; Recovery of Function / physiology; Spinal Cord Injuries / physiopathology; Transcranial Magnetic Stimulation
TL;DR: The association between pelvic limb MEPs and gait scores supports the importance of descending influence on regaining walking after severe TL-SCI in dogs rather than just activation of spinal walking and implies that increases in motor neuron pool excitability might also contribute to motor recovery. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (Web of Science; OpenAlex)
Sources: Web Of Science, Crossref, NC State University Libraries
Added: August 6, 2018

2016 journal article

A Placebo-Controlled, Prospective, Randomized Clinical Trial of Polyethylene Glycol and Methylprednisolone Sodium Succinate in Dogs with Intervertebral Disk Herniation

JOURNAL OF VETERINARY INTERNAL MEDICINE, 30(1), 206–214.

By: N. Olby n, A. Muguet-Chanoit n, J. Lim n, M. Davidian n, C. Mariani n, A. Freeman*, S. Platt*, J. Humphrey n ...

Contributors: N. Olby n, A. Muguet-Chanoit n, J. Lim n, M. Davidian n, C. Mariani n, A. Freeman*, S. Platt*, J. Humphrey n ...

author keywords: Neuroprotection; Paraplegia; Secondary injury; Spinal cord injury
MeSH headings : Animals; Anti-Inflammatory Agents / administration & dosage; Anti-Inflammatory Agents / therapeutic use; Dog Diseases / drug therapy; Dogs; Female; Intervertebral Disc Displacement / drug therapy; Intervertebral Disc Displacement / veterinary; Male; Methylprednisolone Hemisuccinate / administration & dosage; Methylprednisolone Hemisuccinate / therapeutic use; Nociception / drug effects; Polyethylene Glycols / administration & dosage; Polyethylene Glycols / therapeutic use
TL;DR: This clinical trial did not show a benefit of either MPSS or PEG in the treatment of acute, severe thoracolumbar IVDH when used as adjunctive medical treatment administered to dogs presenting within 24 hours of onset of paralysis. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (Web of Science; OpenAlex)
Sources: Web Of Science, NC State University Libraries, ORCID
Added: August 6, 2018

2016 journal article

Acute change in neurological level following canine intervertebral disc herniation

Journal of Small Animal Practice, 57(4), 220–220.

By: A. Castel n & N. Olby n

MeSH headings : Animals; Diagnosis, Differential; Dog Diseases / diagnostic imaging; Dog Diseases / etiology; Dog Diseases / surgery; Dogs; Intervertebral Disc Displacement / complications; Intervertebral Disc Displacement / diagnostic imaging; Intervertebral Disc Displacement / surgery; Intervertebral Disc Displacement / veterinary; Magnetic Resonance Imaging / veterinary; Male; Nervous System Diseases / etiology; Nervous System Diseases / veterinary; Paraplegia / etiology; Paraplegia / veterinary; Postoperative Complications / veterinary; Reflex
UN Sustainable Development Goal Categories
Sources: Web Of Science, Crossref, NC State University Libraries
Added: August 6, 2018

2016 journal article

Clinical and Diagnostic Imaging Features of Brain Herniation in Dogs and Cats

Journal of Veterinary Internal Medicine, 30(5), 1672–1680.

By: M. Lewis n, N. Olby n, P. Early n, C. Mariani n, K. Muñana n, G. Seiler n, E. Griffith n

MeSH headings : Animals; Body Size; Brain / diagnostic imaging; Brain / pathology; Cat Diseases / diagnostic imaging; Cat Diseases / pathology; Cats; Dog Diseases / diagnostic imaging; Dog Diseases / pathology; Dogs; Magnetic Resonance Imaging / veterinary; Retrospective Studies
TL;DR: Brain herniation can be quantified on MRI and more severe CTH based on TTX is associated with a worse short‐term outcome, compared with more severe foramen magnum based on FMH. (via Semantic Scholar)
Sources: NC State University Libraries, Crossref, NC State University Libraries, ORCID
Added: August 6, 2018

2016 review

Clinical characteristics of canine fibrocartilaginous embolic myelopathy (FCE): a systematic review of 393 cases (1973-2013)

[Review of ]. Veterinary Record, 179(25), 650-.

By: K. Bartholomew, K. Stover, N. Olby & S. Moore

Source: NC State University Libraries
Added: August 6, 2018

2016 journal article

Clinical characteristics of canine fibrocartilaginous embolic myelopathy (FCE): a systematic review of 393 cases (1973–2013)

Veterinary Record, 179(25), 650–650.

By: K. Bartholomew*, K. Stover n, N. Olby n & S. Moore*

MeSH headings : Animals; Cartilage Diseases / diagnosis; Cartilage Diseases / veterinary; Dog Diseases / diagnosis; Dogs; Embolism / diagnosis; Embolism / veterinary; Spinal Cord Diseases / diagnosis; Spinal Cord Diseases / veterinary
TL;DR: Prognosis for recovery of ambulation was good to excellent with 85 per cent of cases regaining the ability to walk unassisted, most within 3 weeks, and future prospective studies should evaluate prognosis for more severely affected patients. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Source: Crossref
Added: July 27, 2019

2016 journal article

Effect of Cranberry Extract on the Frequency of Bacteriuria in Dogs with Acute Thoracolumbar Disk Herniation: A Randomized Controlled Clinical Trial

Journal of Veterinary Internal Medicine, 31(1), 60–68.

By: N. Olby n, S. Vaden n, K. Williams n, E. Griffith n, T. Harris n, C. Mariani n, K. Muñana n, P. Early n ...

Contributors: N. Olby n, S. Vaden n, K. Williams n, E. Griffith n, T. Harris n, C. Mariani n, K. Muñana n, P. Early n ...

author keywords: Escherichia coli; Incontinence; Proanthocyanidins; Spinal cord injury
MeSH headings : Administration, Oral; Animals; Anti-Infective Agents / administration & dosage; Anti-Infective Agents / therapeutic use; Bacteriuria / complications; Bacteriuria / drug therapy; Bacteriuria / urine; Bacteriuria / veterinary; Dog Diseases / drug therapy; Dogs; Female; Intervertebral Disc Displacement / complications; Intervertebral Disc Displacement / veterinary; Male; Plant Extracts / administration & dosage; Plant Extracts / therapeutic use; Prospective Studies; Single-Blind Method; Thoracic Vertebrae; Treatment Outcome; Urinary Tract Infections / complications; Urinary Tract Infections / drug therapy; Urinary Tract Infections / urine; Urinary Tract Infections / veterinary; Vaccinium macrocarpon
TL;DR: This clinical trial did not show a benefit of oral cranberry extract but had low power, but a possible association between urine AAA and lower risk of E. coli bacteriuria was identified. (via Semantic Scholar)
Sources: Web Of Science, Crossref, NC State University Libraries, ORCID
Added: August 6, 2018

2016 journal article

Generation of pure cultures of autologous Schwann cells by use of biopsy specimens of the dorsal cutaneous branches of the cervical nerves of young adult dogs

American Journal of Veterinary Research, 77(10), 1166–1174.

By: J. Lim & N. Olby*

MeSH headings : Animals; Biopsy / veterinary; Cadaver; Cell Culture Techniques / veterinary; Cells, Cultured / cytology; Cervical Plexus / cytology; Dogs; Female; Male; Nerve Regeneration; Schwann Cells / cytology
TL;DR: SCs could be cultured from biopsy specimens of dorsal cervical cutaneous nerves and purified and expanded to generate adequate numbers for autologous transplants to treat dogs with spinal cord and peripheral nerve injuries. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Sources: Web Of Science, Crossref, NC State University Libraries
Added: August 6, 2018

2016 journal article

Longitudinal Study of the Relationship among Craniocervical Morphology, Clinical Progression, and Syringomyelia in a Cohort of Cavalier King Charles Spaniels

Journal of Veterinary Internal Medicine, 30(4), 1090–1098.

By: S. Cerda-Gonzalez*, N. Olby n & E. Griffith n

author keywords: Atlantoaxial band; Chiari-like malformation; Dysesthesia; Neuropathic pain
MeSH headings : Animals; Atlanto-Axial Joint / diagnostic imaging; Atlanto-Axial Joint / pathology; Cohort Studies; Dog Diseases / diagnostic imaging; Dog Diseases / pathology; Dogs; Female; Humans; Longitudinal Studies; Magnetic Resonance Imaging / veterinary; Male; Pedigree; Severity of Illness Index; Surveys and Questionnaires; Syringomyelia / diagnostic imaging; Syringomyelia / pathology; Syringomyelia / veterinary
TL;DR: The morphology of the CCJ at initial imaging did not predict development of either new or worsened signs or syringomyelia by the time of re‐evaluation, and Craniocervical junction anomalies assessed in this study did not appear predictive of future clinical status or syringsomyelia in this cohort. (via Semantic Scholar)
Sources: Web Of Science, Crossref, NC State University Libraries
Added: August 6, 2018

2016 journal article

Mechanical and Thermal Sensory Testing in Normal Chondrodystrophoid Dogs and Dogs with Spinal Cord Injury caused by Thoracolumbar Intervertebral Disc Herniations

Journal of Veterinary Internal Medicine, 30(2), 627–635.

Contributors: A. Gorney n, S. Blau n, C. Dohse n, E. Griffith n, K. Williams n, J. Lim n, D. Knazovicky n, B. Lascelles n, N. Olby n

author keywords: Allodynia; Mechanical threshold; Nociception; Quantitative sensory testing; Thermal threshold
MeSH headings : Animals; Cold Temperature; Dog Diseases / diagnosis; Dogs; Female; Hot Temperature; Intervertebral Disc Displacement / diagnosis; Intervertebral Disc Displacement / veterinary; Male; Pressure; Sensory Thresholds / physiology; Spinal Cord Injuries / diagnosis; Spinal Cord Injuries / veterinary
TL;DR: The differences in sensation among neurologic grades indicate that these techniques can be used to further characterize recovery of SCI dogs and can be measured reliably in chondrodystrophoid dogs and are altered by SCI. (via Semantic Scholar)
Sources: Web Of Science, NC State University Libraries, ORCID, Crossref
Added: August 6, 2018

2016 journal article

Recovery of stepping and coordination in dogs following acute thoracolumbar intervertebral disc herniations

The Veterinary Journal, 213, 59–63.

By: C. Rousse n, N. Olby n, K. Williams n, T. Harris n, E. Griffith n, C. Mariani n, K. Muñana n, P. Early n

Contributors: C. Rousse n, N. Olby n, K. Williams n, T. Harris n, E. Griffith n, C. Mariani n, K. Muñana n, P. Early n

author keywords: Canine; Gait; Locomotion; Paralysis; Spinal cord injury
MeSH headings : Acute Disease; Animals; Dog Diseases / etiology; Dog Diseases / surgery; Dogs; Female; Forelimb / physiology; Hindlimb / physiology; Intervertebral Disc / pathology; Intervertebral Disc / surgery; Intervertebral Disc Displacement / etiology; Intervertebral Disc Displacement / surgery; Intervertebral Disc Displacement / veterinary; Male; Prospective Studies; Spinal Cord Injuries / etiology; Spinal Cord Injuries / surgery; Spinal Cord Injuries / veterinary; Walking
TL;DR: Recovery of coordination was incomplete in dogs that showed good recovery of stepping in the 6 weeks following surgical decompression of dogs with TL-IVDH. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (Web of Science; OpenAlex)
Sources: Web Of Science, Crossref, NC State University Libraries, ORCID
Added: August 6, 2018

2016 journal article

Use of posaconazole for treatment of disseminated protothecosis in a dog

Veterinary Record Case Reports, 4(2), e000350.

By: B. Enders, N. Olby* & C. Mariani*

TL;DR: The clinical improvement produced by posaconazole in this case suggests it may be an effective therapy for this typically fatal disease, but it may currently be cost prohibitive. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (OpenAlex)
Sources: Crossref, NC State University Libraries, ORCID
Added: September 13, 2020

2015 journal article

A rare homozygous MFSD8 single-base-pair deletion and frameshift in the whole genome sequence of a Chinese Crested dog with neuronal ceroid lipofuscinosis

BMC Veterinary Research, 10(1), 960.

By: J. Guo*, D. O’Brien*, T. Mhlanga-Mutangadura*, N. Olby n, J. Taylor*, R. Schnabel*, M. Katz*, G. Johnson*

author keywords: MFSD8; Neuronal ceroid lipofuscinosis; Chinese Crested; Whole genome sequence
MeSH headings : Animals; Cerebellum / pathology; Dog Diseases / genetics; Dog Diseases / pathology; Dogs / genetics; Frameshift Mutation / genetics; Gene Deletion; Genome / genetics; Homozygote; Magnetic Resonance Imaging / veterinary; Male; Membrane Transport Proteins / genetics; Neuroimaging / veterinary; Neuronal Ceroid-Lipofuscinoses / genetics; Neuronal Ceroid-Lipofuscinoses / veterinary
TL;DR: The neurodegenerative disease of the Chinese Crested rescue dog was neuronal ceroid lipofuscinosis and that homozygosity for the MFSD8:c.843delT sequence variant was very likely to be the molecular-genetic cause of the disease. (via Semantic Scholar)
Sources: Crossref, NC State University Libraries, NC State University Libraries
Added: August 6, 2018

2015 journal article

Clinical characteristics of Scottie Cramp in 31 cases

Journal of Small Animal Practice, 56(4), 276–280.

By: G. Urkasemsin n & N. Olby n

MeSH headings : Animals; Breeding; Cerebellum / pathology; Dog Diseases / drug therapy; Dog Diseases / genetics; Dog Diseases / physiopathology; Dogs; Female; Fluoxetine / therapeutic use; Genetic Predisposition to Disease; Male; Muscle Cramp / drug therapy; Muscle Cramp / genetics; Muscle Cramp / physiopathology; Muscle Cramp / veterinary; Muscle Hypertonia / drug therapy; Muscle Hypertonia / genetics; Muscle Hypertonia / physiopathology; Muscle Hypertonia / veterinary; Selective Serotonin Reuptake Inhibitors / therapeutic use; Severity of Illness Index; Sex Factors; Spinocerebellar Degenerations / genetics; Spinocerebellar Degenerations / physiopathology; Spinocerebellar Degenerations / veterinary
TL;DR: The disorder recognised as Scottie Cramp by dog owners includes dogs with hind limb spasticity in addition to generalised cramping, which usually improve over time without specific treatment. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (Web of Science; OpenAlex)
Sources: Web Of Science, Crossref, NC State University Libraries
Added: August 6, 2018

2015 journal article

Dorsal Compressive Atlantoaxial Bands and the Craniocervical Junction Syndrome: Association with Clinical Signs and Syringomyelia in Mature Cavalier King Charles Spaniels

Journal of Veterinary Internal Medicine, 29(3), 887–892.

By: S. Cerda-Gonzalez*, N. Olby n & E. Griffith n

author keywords: Chiari-like; Compression index; Fibrous band; Magnetic resonance imaging
MeSH headings : Animals; Atlanto-Axial Joint / pathology; Dog Diseases / pathology; Dogs; Female; Magnetic Resonance Imaging / veterinary; Male; Spinal Cord Compression / diagnosis; Spinal Cord Compression / pathology; Spinal Cord Compression / veterinary; Syndrome; Syringomyelia / diagnosis; Syringomyelia / pathology; Syringomyelia / veterinary
TL;DR: Positioning of dogs in extension during MRI enhances the sensitivity of the study for detecting this important abnormality, and there were significant associations among AA bands, clinical signs, and SM in dogs with CM. (via Semantic Scholar)
Sources: Web Of Science, Crossref, NC State University Libraries
Added: August 6, 2018

2015 journal article

Evaluation of a DLA-79 allele associated with multiple immune-mediated diseases in dogs

Immunogenetics, 68(3), 205–217.

By: S. Friedenberg n, G. Buhrman n, L. Chdid n, N. Olby n, T. Olivry n, J. Guillaumin*, T. O’Toole*, R. Goggs* ...

Contributors: S. Friedenberg n, G. Buhrman n, L. Chdid n, N. Olby n, T. Olivry n, J. Guillaumin*, T. O’Toole*, R. Goggs* ...

author keywords: Canine; Immune-mediated disease; Dog leukocyte antigen; Major histocompatibility complex class Ib
MeSH headings : Alleles; Amino Acid Substitution; Animals; Autoimmune Diseases / genetics; Autoimmune Diseases / immunology; Binding Sites; Dog Diseases / genetics; Dog Diseases / immunology; Dogs; Exons; Gene Frequency; Genetic Predisposition to Disease; Genotype; Histocompatibility Antigens Class I / chemistry; Histocompatibility Antigens Class I / genetics; Histocompatibility Antigens Class I / immunology; Immune System Diseases / veterinary; Meta-Analysis as Topic; Models, Molecular; Peptides / chemistry; Peptides / metabolism; Phenotype; Polymorphism, Single Nucleotide; Protein Conformation; Reproducibility of Results; Structure-Activity Relationship
TL;DR: A strong association is demonstrated between two polymorphic positions (10 bp apart) in exon 2 of one allele in D LA-79, DLA-79*001:02, and multiple immune-mediated diseases, resulting in F33L and N37D amino acid changes that are likely to affect critical interactions with the peptide N-terminus. (via Semantic Scholar)
Sources: Web Of Science, Crossref, NC State University Libraries, ORCID
Added: August 6, 2018

2015 journal article

Histiocytic Sarcoma with Central Nervous System Involvement in Dogs: 19 Cases (2006-2012)

Journal of Veterinary Internal Medicine, 29(2), 607–613.

By: C. Mariani n, M. Jennings n, N. Olby n, L. Borst n, J. Brown n, I. Robertson n, G. Seiler n, E. MacKillop

author keywords: Brain tumor; Malignant histiocytosis; Round cell tumor; Spinal cord tumor
MeSH headings : Animals; Central Nervous System Neoplasms / pathology; Central Nervous System Neoplasms / veterinary; Dog Diseases / pathology; Dogs; Female; Histiocytic Sarcoma / pathology; Histiocytic Sarcoma / veterinary; Male; Retrospective Studies
TL;DR: Some unique imaging and clinicopathologic characteristics, particularly brain herniation, profound meningeal enhancement, and pleocytosis in combination with 1 or more mass lesions, might help to differentiate this neoplasm from others involving the CNS, although this requires further study. (via Semantic Scholar)
Sources: Web Of Science, Crossref, NC State University Libraries, ORCID
Added: August 6, 2018

2015 journal article

Medullary Position at the Craniocervical Junction in Mature Cavalier King Charles Spaniels: Relationship with Neurologic Signs and Syringomyelia

Journal of Veterinary Internal Medicine, 29(3), 882–886.

By: S. Cerda-Gonzalez*, N. Olby n & E. Griffith n

author keywords: Cervicomedullary; Chiari-like; Medullary elevation; Medullary kinking
MeSH headings : Animals; Dog Diseases / pathology; Dogs; Female; Magnetic Resonance Imaging / veterinary; Male; Medulla Oblongata / pathology; Spinal Cord / pathology; Syringomyelia / pathology; Syringomyelia / veterinary
TL;DR: There is a significant association between medullary elevation and clinical signs, whereas more caudal brainstem positions appear related to the presence of syringomyelia. (via Semantic Scholar)
Sources: Web Of Science, Crossref, NC State University Libraries
Added: August 6, 2018

2015 journal article

The rationale for durotomy in surgical treatment of intervertebral disc disease

Advances in Intervertebral Disc Disease in Dogs and Cats, 251–254.

By: F. Forterre, N. Reves & N. Olby

Source: NC State University Libraries
Added: August 6, 2018

2014 journal article

Advances in Veterinary Neurology

Veterinary Clinics of North America: Small Animal Practice, 44(6), xi-xii.

By: N. Olby n & N. Jeffery*

MeSH headings : Animals; Central Nervous System Diseases / diagnosis; Central Nervous System Diseases / pathology; Central Nervous System Diseases / therapy; Central Nervous System Diseases / veterinary; Neurology / trends; Veterinary Medicine / trends
Sources: Crossref, NC State University Libraries
Added: July 27, 2019

2014 journal article

Advances in veterinary neurology preface

Veterinary Clinics of North America. Small Animal Practice, 44(6), XI-.

By: N. Olby & N. Jeffery

Source: NC State University Libraries
Added: August 6, 2018

2014 journal article

Canine Hereditary Ataxia

Veterinary Clinics of North America: Small Animal Practice, 44(6), 1075–1089.

By: G. Urkasemsin* & N. Olby n

author keywords: Cerebellar abiotrophy; Spinocerebellar; Purkinje neuron; Granuloprival degeneration
MeSH headings : Animals; Dog Diseases / classification; Dog Diseases / diagnosis; Dog Diseases / genetics; Dog Diseases / therapy; Dogs; Genetic Predisposition to Disease; Spinocerebellar Degenerations / classification; Spinocerebellar Degenerations / diagnosis; Spinocerebellar Degenerations / genetics; Spinocerebellar Degenerations / therapy; Spinocerebellar Degenerations / veterinary
TL;DR: A breed-related neurodegenerative process should be suspected in any pure bred dog with slowly progressive, symmetric signs of ataxia. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (Web of Science; OpenAlex)
Sources: Crossref, NC State University Libraries, NC State University Libraries
Added: August 6, 2018

2014 journal article

Canine Hereditary Ataxia in Old English Sheepdogs and Gordon Setters Is Associated with a Defect in the Autophagy Gene Encoding RAB24

PLoS Genetics, 10(2), e1003991.

By: C. Agler n, D. Nielsen n, G. Urkasemsin n, A. Singleton*, N. Tonomura*, S. Sigurdsson*, R. Tang*, K. Linder n ...

Ed(s): T. Leeb

MeSH headings : Animals; Autophagy / genetics; Cerebellar Cortex / pathology; Chromosome Mapping; Dog Diseases / genetics; Dog Diseases / pathology; Dogs; Genome-Wide Association Study; High-Throughput Nucleotide Sequencing; Humans; Mice; Mutation; Polymorphism, Single Nucleotide; Spinocerebellar Degenerations / etiology; Spinocerebellar Degenerations / genetics; rab GTP-Binding Proteins / genetics
TL;DR: Histopathology, immunohistochemistry and ultrastructural evaluation of the brains of affected dogs from both breeds identified dramatic Purkinje neuron loss with axonal spheroids, accumulation of autophagosomes, ubiquitin positive inclusions and a diffuse increase in cytoplasmic neuronal ubiquit inclusions. (via Semantic Scholar)
Sources: Crossref, NC State University Libraries, NC State University Libraries
Added: August 6, 2018

2014 journal article

Canine Paroxysmal Movement Disorders

Veterinary Clinics of North America: Small Animal Practice, 44(6), 1091–1102.

By: G. Urkasemsin* & N. Olby n

author keywords: Episodic movement disorders; Hypertonicity; Episodic falling; Hyperkinetic episode; Paroxysmal dyskinesia; Scottie cramp
MeSH headings : Animals; Chorea / diagnosis; Chorea / genetics; Chorea / pathology; Chorea / virology; Dog Diseases / diagnosis; Dog Diseases / genetics; Dog Diseases / pathology; Dogs; Genetic Predisposition to Disease
TL;DR: A mutation in the gene for brevican (BCAN) has been identified as the cause of Episodic Falling in Cavalier King Charles spaniels and further elucidation of the genetic causes will enhance the ability to identify and treat these canine diseases. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (Web of Science; OpenAlex)
Sources: Crossref, NC State University Libraries, NC State University Libraries
Added: August 6, 2018

2014 journal article

Gait scoring in dogs with thoracolumbar spinal cord injuries when walking on a treadmill

BMC Veterinary Research, 10(1), 58.

By: N. Olby n, J. Lim n, K. Babb n, K. Bach n, C. Domaracki n, K. Williams n, E. Griffith n, T. Harris n, A. Muguet-Chanoit n

author keywords: Coordination; Footstep sequence; Paresis; Paralysis; Regularity index; Intervertebral disc herniation; Spinal cord injury
MeSH headings : Animals; Biomechanical Phenomena; Dog Diseases / diagnosis; Dogs / injuries; Forelimb; Gait / physiology; Gait Disorders, Neurologic / diagnosis; Gait Disorders, Neurologic / veterinary; Hindlimb; Spinal Cord Injuries; Walking / physiology
TL;DR: Dogs with naturally occurring spinal cord injury can walk on a treadmill without prior training and their hind limb function can be scored reliably using a stepping score and coordination score. (via Semantic Scholar)
Sources: Crossref, NC State University Libraries, NC State University Libraries
Added: August 6, 2018

2014 journal article

Potassium Channel Antagonists 4-Aminopyridine and the T-Butyl Carbamate Derivative of 4-Aminopyridine Improve Hind Limb Function in Chronically Non-Ambulatory Dogs; A Blinded, Placebo-Controlled Trial

PLoS ONE, 9(12), e116139.

By: J. Lim n, A. Muguet-Chanoit n, D. Smith*, E. Laber n & N. Olby n

Ed(s): H. Sabaawy

MeSH headings : 4-Aminopyridine / adverse effects; 4-Aminopyridine / analogs & derivatives; 4-Aminopyridine / therapeutic use; Animals; Demyelinating Diseases / drug therapy; Dogs; Double-Blind Method; Female; Gait / drug effects; Hindlimb / physiopathology; Lameness, Animal / drug therapy; Male; Paralysis / drug therapy; Placebos / therapeutic use; Potassium Channel Blockers / therapeutic use; Spinal Cord Injuries / drug therapy; Treatment Outcome; Walking / physiology
TL;DR: Both 4-AP and t- butyl significantly improved supported stepping ability in dogs with chronic spinal cord injury with no adverse effects noted with t-butyl. (via Semantic Scholar)
Sources: Crossref, NC State University Libraries, NC State University Libraries
Added: August 6, 2018

2013 journal article

Alternating Current Electric Fields of Varying Frequencies: Effects on Proliferation and Differentiation of Porcine Neural Progenitor Cells

Cellular Reprogramming, 15(5), 405–412.

By: J. Lim n, S. McCullen n, J. Piedrahita n, E. Loboa n & N. Olby n

MeSH headings : Animals; Cell Differentiation; Cell Proliferation; Cells, Cultured; Electricity; Electrodes; Fluorescence; Glial Fibrillary Acidic Protein / metabolism; Neural Stem Cells / cytology; Swine; Swine, Miniature; Tubulin / metabolism
TL;DR: Higher frequency stimulation of low-frequency alternating current EFs via IDEs did not alter the alignment and proliferation of porcine neural progenitor cells, but higher frequency stimulation appeared to delay differentiation into mature astrocytes. (via Semantic Scholar)
Sources: Web Of Science, Crossref, NC State University Libraries
Added: August 6, 2018

2013 journal article

Assessment of cord dorsum potentials from caudal nerves in anesthetized clinically normal adult dogs without or during neuromuscular blockade

American Journal of Veterinary Research, 74(4), 616–620.

By: J. Campbell n, N. Olby n, J. Hash n & B. Lascelles

MeSH headings : Action Potentials / drug effects; Action Potentials / physiology; Anesthesia / veterinary; Animals; Dogs; Female; Male; Nerve Net / drug effects; Nerve Net / physiology; Neuromuscular Blockade / veterinary; Spinal Cord / drug effects; Spinal Cord / physiology
TL;DR: This technique may be useful as a tool to assess the caudal nerve roots in dogs suspected of having compressive lumbosacral disease or myelopathies affecting the lumbar intumescence. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Sources: Web Of Science, Crossref, NC State University Libraries, ORCID
Added: August 6, 2018

2013 journal article

Growth Requirements and Chromosomal Instability of Induced Pluripotent Stem Cells Generated from Adult Canine Fibroblasts

Stem Cells and Development, 22(6), 951–963.

By: S. Koh n, R. Thomas n, S. Tsai n, S. Bischoff n, J. Lim n, M. Breen n, N. Olby n, J. Piedrahita n

MeSH headings : Alkaline Phosphatase / metabolism; Animals; Antigens, Differentiation / genetics; Antigens, Differentiation / metabolism; Cell Differentiation; Cell Shape; Cells, Cultured; Chromosomal Instability; Coculture Techniques; Comparative Genomic Hybridization; Dogs; Fibroblasts / physiology; Gene Expression; In Situ Hybridization, Fluorescence; Induced Pluripotent Stem Cells / enzymology; Induced Pluripotent Stem Cells / pathology; Induced Pluripotent Stem Cells / transplantation; Kruppel-Like Factor 4; Mice; Mice, SCID; Recombinant Proteins / biosynthesis; Recombinant Proteins / genetics; Teratoma / genetics; Teratoma / pathology; Transcription Factors / biosynthesis; Transcription Factors / genetics
TL;DR: The isolated ciPSCs have similar characteristics to ESCs from other species, but the exact cellular mechanisms behind their unique co-dependency on both FGF2 and LIF are still unknown. (via Semantic Scholar)
Sources: Web Of Science, Crossref, NC State University Libraries
Added: August 6, 2018

2013 journal article

Intervertebral Disk Degeneration in Dogs: Consequences, Diagnosis, Treatment, and Future Directions

Journal of Veterinary Internal Medicine, 27(6), 1318–1333.

author keywords: Compression; Computed tomography; Contusion; Magnetic resonance imaging; Prognosis; Spinal cord injury
MeSH headings : Animals; Clinical Trials as Topic / veterinary; Dog Diseases / diagnosis; Dog Diseases / pathology; Dog Diseases / surgery; Dogs; Intervertebral Disc Degeneration / diagnosis; Intervertebral Disc Degeneration / pathology; Intervertebral Disc Degeneration / surgery; Intervertebral Disc Degeneration / veterinary; Magnetic Resonance Imaging / veterinary; Spinal Cord Compression / diagnosis; Spinal Cord Compression / pathology; Spinal Cord Compression / surgery; Spinal Cord Compression / veterinary; Tomography, X-Ray Computed / veterinary
TL;DR: This review summarizes the advances in diagnosis and treatment of IVDD that have been made since the 1950s and discusses new approaches to treatment of the associated spinal cord injury and new methods by which to classify injury severity that are currently under development. (via Semantic Scholar)
Sources: Web Of Science, Crossref, NC State University Libraries
Added: August 6, 2018

2013 journal article

Long-Term Effect of Cervical Distraction and Stabilization on Neurological Status and Imaging Findings in Giant Breed Dogs With Cervical Stenotic Myelopathy

Veterinary Surgery, 42(6), 701–709.

By: M. Lewis n, N. Olby n, N. Sharp & P. Early n

MeSH headings : Animals; Body Size; Cervical Vertebrae / pathology; Cervical Vertebrae / surgery; Dog Diseases / diagnostic imaging; Dog Diseases / pathology; Dog Diseases / surgery; Dogs; Female; Male; Retrospective Studies; Spinal Cord Compression / complications; Spinal Cord Compression / surgery; Spinal Cord Compression / veterinary; Spinal Stenosis / pathology; Spinal Stenosis / surgery; Spinal Stenosis / veterinary; Tomography, X-Ray Computed
TL;DR: Distraction and stabilization with PMMA plugs and bone grafts is a safe surgical option for giant breed dogs with CSM with a single site of lateral or dorsolateral compression and long-term recurrence was common among dogs with multiple sites of compression. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (Web of Science; OpenAlex)
Sources: Web Of Science, Crossref, NC State University Libraries
Added: August 6, 2018

2012 journal article

Centronuclear Myopathy in Labrador Retrievers: A Recent Founder Mutation in the PTPLA Gene Has Rapidly Disseminated Worldwide

PLoS ONE, 7(10), e46408.

By: M. Maurer*, J. Mary*, L. Guillaud*, M. Fender, M. Pelé*, T. Bilzer*, N. Olby n, J. Penderis* ...

Ed(s): R. Veitia

MeSH headings : Alleles; Animals; Dog Diseases / genetics; Dogs; Founder Effect; Genes, Recessive; Mutation; Myopathies, Structural, Congenital / genetics; Myopathies, Structural, Congenital / veterinary; Phenotype; Protein Tyrosine Phosphatases / genetics
TL;DR: Haplotype analysis demonstrated that the PTPLAcnm allele resulted from a single and recent mutational event that may have rapidly disseminated through the extensive use of popular sires, and will help define the integrated role of PTPLA in the existing CNM gene network. (via Semantic Scholar)
Sources: Crossref, NC State University Libraries, NC State University Libraries
Added: August 6, 2018

2012 journal article

Characterization of Immune Cell Infiltration Into Canine Intracranial Meningiomas

VETERINARY PATHOLOGY, 49(5), 784–795.

By: L. Boozer n, T. Davis n, L. Borst n, K. Zseltvay n, N. Olby n & C. Mariani n

author keywords: brain; dog; immunohistochemistry; lymphocyte; meningioma; microglia; Toll-like receptor; tumor
MeSH headings : Animals; Antigens, CD / analysis; Antigens, CD / immunology; Biomarkers, Tumor / metabolism; Cytokines / metabolism; Dog Diseases / immunology; Dog Diseases / pathology; Dogs; Female; Forkhead Transcription Factors / metabolism; Immunohistochemistry / veterinary; Lymphocyte Subsets / immunology; Lymphocytes, Tumor-Infiltrating / immunology; Macrophages / immunology; Male; Meningeal Neoplasms / immunology; Meningeal Neoplasms / pathology; Meningeal Neoplasms / veterinary; Meningioma / immunology; Meningioma / pathology; Meningioma / veterinary; Paraffin Embedding / veterinary; Toll-Like Receptor 4 / metabolism; Toll-Like Receptor 9 / metabolism
TL;DR: Investigation of the presence of a variety of immune cell subsets within canine intracranial meningiomas suggests that evaluation of this immune cell infiltrate may provide important prognostic information and may be useful in the design of novel therapies. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Sources: Web Of Science, NC State University Libraries, ORCID
Added: August 6, 2018

2012 journal article

Evaluation of Levetiracetam as Adjunctive Treatment for Refractory Canine Epilepsy: A Randomized, Placebo-Controlled, Crossover Trial

JOURNAL OF VETERINARY INTERNAL MEDICINE, 26(2), 341–348.

By: K. Munana n, W. Thomas*, K. Inzana*, J. Nettifee-Osborne n, K. McLucas*, N. Olby n, C. Mariani n, P. Early n

Contributors: K. Muñana n, W. Thomas*, K. Inzana*, J. Nettifee-Osborne n, K. McLucas*, N. Olby n, C. Mariani n, P. Early n

author keywords: Clinical pharmacology; CNS disorders; Dog; Epilepsy; Neurology; Seizures
MeSH headings : Animals; Anticonvulsants / administration & dosage; Anticonvulsants / adverse effects; Anticonvulsants / blood; Cross-Over Studies; Dog Diseases / blood; Dog Diseases / drug therapy; Dogs; Double-Blind Method; Epilepsy / blood; Epilepsy / drug therapy; Epilepsy / veterinary; Female; Levetiracetam; Male; Piracetam / administration & dosage; Piracetam / adverse effects; Piracetam / analogs & derivatives; Piracetam / blood; Quality of Life; Seizures / blood; Seizures / drug therapy; Seizures / veterinary; Statistics, Nonparametric
TL;DR: Adjunctive treatment with LEV appears safe in epileptic dogs and effectiveness over placebo was not demonstrated, although the power of the study was limited. (via Semantic Scholar)
Sources: Web Of Science, NC State University Libraries, ORCID
Added: August 6, 2018

2012 journal article

GENERATION AND CHARACTERISATION OF INDUCED PLURIPOTENT STEM CELLS (iPSCs) FROM ADULT CANINE FIBROBLASTS

Reproduction, Fertility and Development, 24(1), 285.

By: J. Piedrahita n, S. Koh n & N. Olby n

TL;DR: The isolated canine iPSCs have similar characteristics to ESCs from other species, but the exact cellular mechanisms behind their unique co-dependency on both FGF and LIF is still unknown. (via Semantic Scholar)
Source: Crossref
Added: February 24, 2020

2012 conference paper

Generation and characterization of induced pluripotent stem cells (iPS) from adult canine fibroblasts

Reproduction in Domestic Animals, 47, 418–419.

By: S. Koh, S. Tsai, S. Bischoff, R. Thomas, J. Lim, M. Breen, N. Olby, J. Piedrahita

Source: NC State University Libraries
Added: August 6, 2018

2012 journal article

Isolation and characterization of neural progenitor cells from adult canine brains

American Journal of Veterinary Research, 73(12), 1963–1968.

By: J. Lim n, S. Koh*, N. Olby*, J. Piedrahita* & C. Mariani*

MeSH headings : Animals; Cell Culture Techniques / veterinary; Cell Differentiation; Cell Lineage; Dogs; Female; Hippocampus / cytology; Hippocampus / metabolism; Immunohistochemistry / veterinary; Lateral Ventricles / cytology; Lateral Ventricles / metabolism; Male; Neural Stem Cells / cytology; Neural Stem Cells / physiology; RNA / analysis; Reverse Transcriptase Polymerase Chain Reaction
TL;DR: Results suggested the persistence of SOX2- Positive, nestin-positive, GFAP- positive,GFAP-Positive, OCT4-negative, and NANOG-negative neural progenitor cells in the SVZ and SGZ regions of mature canine brains, which are capable of producing multiple cell lineages. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Sources: Web Of Science, NC State University Libraries, Crossref, ORCID
Added: August 6, 2018

2012 journal article

Mapping of Purkinje Neuron Loss and Polyglucosan Body Accumulation in Hereditary Cerebellar Degeneration in Scottish Terriers

VETERINARY PATHOLOGY, 49(5), 852–859.

By: G. Urkasemsin n, K. Linder n, J. Bell*, A. Lahunta* & N. Olby n

author keywords: dog; cerebellar abiotrophy; cerebellar ataxia; cerebellar cortex; inclusion; molecular layer; polyglucosan body
MeSH headings : Aging / pathology; Animals; Case-Control Studies; Cerebellar Cortex / metabolism; Cerebellar Cortex / pathology; Cerebellar Cortex / ultrastructure; Cerebellum / metabolism; Cerebellum / pathology; Cerebellum / ultrastructure; Dog Diseases / genetics; Dog Diseases / metabolism; Dog Diseases / pathology; Dogs; Female; Glucans / metabolism; Immunohistochemistry / veterinary; Inclusion Bodies / metabolism; Inclusion Bodies / pathology; Inclusion Bodies / ultrastructure; Male; Microscopy, Electron, Transmission / veterinary; Purkinje Cells / metabolism; Purkinje Cells / pathology; Purkinje Cells / ultrastructure; Spinocerebellar Degenerations / genetics; Spinocerebellar Degenerations / metabolism; Spinocerebellar Degenerations / pathology; Spinocerebellar Degenerations / veterinary
TL;DR: Significant Purkinje cell loss and increased polyglucosan bodies in the cerebellum of affected Scottish Terriers are demonstrated. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018

2012 journal article

TP53 Mutations in Canine Brain Tumors

VETERINARY PATHOLOGY, 49(5), 796–801.

By: D. York*, R. Higgins*, R. LeCouteur*, A. Wolfe*, R. Grahn*, N. Olby n, M. Campbell*, P. Dickinson*

author keywords: cancer genes; dog; gDNA; nervous system; oncology; polymerase chain reaction; sequencing
MeSH headings : Animals; Astrocytoma / genetics; Astrocytoma / veterinary; Brain Neoplasms / genetics; Brain Neoplasms / veterinary; DNA, Complementary / genetics; DNA, Neoplasm / chemistry; DNA, Neoplasm / genetics; Dog Diseases / genetics; Dogs; Exons / genetics; Female; Gene Frequency; Genes, p53 / genetics; Male; Mutation; RNA, Neoplasm / genetics; Sequence Analysis, DNA
TL;DR: Genomic DNA from a series of 37 glial and 51 nonglial canine brain tumors was sequenced to determine the frequency of TP53 gene mutations involving exons 3–9, and exonic mutations were found in 3 of 88 tumors and specifically in 1 of 18 astrocytic tumors. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (Web of Science; OpenAlex)
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018

2011 journal article

Clinical progression of X-linked muscular dystrophy in two German Shorthaired Pointers

Journal of the American Veterinary Medical Association, 238(2), 207–212.

By: N. Olby n, N. Sharp n, P. Nghiem n, B. Keene n, T. DeFrancesco n, J. Sidley n, J. Kornegay n, S. Schatzberg n

MeSH headings : Animals; Dog Diseases / genetics; Dog Diseases / pathology; Dogs; Male; Muscular Dystrophy, Animal / genetics; X Chromosome
TL;DR: The clinical progression of muscular dystrophy in the 2 GSHPs was compared with that for other breeds and species with dystrophin-deficient conditions, and the potential basis for the phenotypic variation observed between these littermates, along with potential therapeutic ramifications for dogs and humans was evaluated. (via Semantic Scholar)
UN Sustainable Development Goal Categories
2. Zero Hunger (OpenAlex)
Sources: Crossref, NC State University Libraries
Added: November 16, 2019

2011 journal article

Genome-wide linkage study of atopic dermatitis in West Highland White Terriers

BMC Genetics, 12(1), 37.

By: C. Salzmann n, T. Olivry n, D. Nielsen n, J. Paps n, T. Harris n & N. Olby n

Contributors: C. Salzmann n, T. Olivry n, D. Nielsen n, J. Paps n, T. Harris n & N. Olby n

MeSH headings : Animals; Chromosome Mapping; Dermatitis, Atopic / genetics; Dermatitis, Atopic / veterinary; Dog Diseases / genetics; Dogs; Genetic Linkage; Genotype
TL;DR: The study was unable to detect any chromosomal regions significantly linked to canine AD, and a genome-wide SNP association study in a larger cohort of WHWTs may prove more successful by providing higher density coverage and higher statistical power. (via Semantic Scholar)
Sources: Crossref, NC State University Libraries, ORCID, NC State University Libraries
Added: August 6, 2018

2011 conference paper

Perspectives on transgenic livestock in agriculture and biomedicine: An update

Reproduction, Fertility and Development, 23(1), 56–63.

By: J. Piedrahita & N. Olby

Source: NC State University Libraries
Added: August 6, 2018

2011 journal article

Perspectives on transgenic livestock in agriculture and biomedicine: an update

Reproduction, Fertility and Development, 23(1), 56.

By: J. Piedrahita n & N. Olby n

author keywords: animal models; bioreactors; somatic cell nuclear transfer; spinal cord repair; xenotransplantation