Works (223)
Updated: October 27th, 2024 05:04
2024 journal article
A randomized, controlled clinical trial demonstrates improved owner-assessed cognitive function in senior dogs receiving a senolytic and NAD plus precursor combination
SCIENTIFIC REPORTS, 14(1).
author keywords: Aging; Senolytic; NAD plus; Canine cognitive dysfunction syndrome; Cognitive impairment; Longevity
open access via www.nature.com (publisher PDF)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, NC State University Libraries
Added: June 24, 2024
2024 article
ACVIM consensus statement on diagnosis and management of urinary incontinence in dogs
Kendall, A., Byron, J. K., Westropp, J. L., Coates, J. R., Vaden, S., Adin, C., … Berent, A. (2024, January 13). JOURNAL OF VETERINARY INTERNAL MEDICINE, Vol. 1.
author keywords: canine; incontinence; urinary
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
Sources: Web Of Science, NC State University Libraries
Added: February 12, 2024
2024 article
ALSUntangled #76: Wahls protocol
Li, X., Wicks, P., Brown, A., Shivaprasad, A., Greene, M., Crayle, J., … Bedlack, R. (2024, October 9). AMYOTROPHIC LATERAL SCLEROSIS AND FRONTOTEMPORAL DEGENERATION, Vol. 10.
author keywords: ALS; Wahls protocol; neuroinflammation; oxidative stress
Sources: Web Of Science, NC State University Libraries
Added: October 21, 2024
2024 article
Clinical and imaging findings in dogs with nerve root signature associated with cervical intervertebral disc herniation
Schachar, J., Bocage, A., Nelson, N. C., Early, P. J., Mariani, C. L., Olby, N. J., & Munana, K. R. (2024, January 12). JOURNAL OF VETERINARY INTERNAL MEDICINE, Vol. 1.
author keywords: cervical radiculopathy; intraforaminal disc herniation; magnetic resonance imaging; thoracic limb lameness
TL;DR:
NRS is most prevalent with C6‐C7 intervertebral disc involvement, suggesting that there might be unique anatomic factors that contribute to development of NRS at this site, but can be a clinical manifestation of IVDH occurring anywhere along the cervical spine.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, NC State University Libraries, ORCID
Added: January 13, 2024
2024 journal article
Cross-sectional and longitudinal analysis of health-related quality of life (HRQoL) in senior and geriatric dogs
PLOS ONE.
Ed(s): J. Suchodolski
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(OpenAlex)
Source: ORCID
Added: September 8, 2024
2024 journal article
Establishing a clinically applicable frailty phenotype screening tool for aging dogs
FRONTIERS IN VETERINARY SCIENCE, 11.
author keywords: frailty; canine frailty; frailty phenotype; geriatric; aging dogs
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(OpenAlex)
Sources: Web Of Science, NC State University Libraries
Added: October 21, 2024
2024 article
Pharmacokinetics of subcutaneous ketamine administration via the Omnipod® system in dogs
Colon, C., Early, P., Munana, K., Olby, N., Mariani, C., Mancini, S., … Messenger, K. (2024, March 27). JOURNAL OF VETERINARY PHARMACOLOGY AND THERAPEUTICS, Vol. 3.
author keywords: analgesia; canine; ketamine; novel; veterinary
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
Sources: Web Of Science, NC State University Libraries
Added: April 8, 2024
2024 journal article
Voxelwise analysis of the central hearing pathway in senior dogs reveals changes associated with fractional lifespan
SCIENTIFIC REPORTS, 14(1).
author keywords: Age-related hearing loss; Central presbycusis; Canine; Diffusion tensor imaging
Sources: Web Of Science, NC State University Libraries
Added: August 19, 2024
2023 journal article
A novel task of canine olfaction for use in adult and senior pet dogs
SCIENTIFIC REPORTS, 13(1).
MeSH headings : Dogs; Animals; Smell; Food; Aging; Neuropsychological Tests
TL;DR:
A novel olfaction test using spontaneous search behavior in dogs to find a hidden food treat in a three-choice task with both light-phase and dark-phase conditions is described, making it feasible to compare between and within groups of pet dogs.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: ORCID, Web Of Science, NC State University Libraries
Added: February 19, 2023
2023 review
A review of frailty instruments in human medicine and proposal of a frailty instrument for dogs
[Review of ]. FRONTIERS IN VETERINARY SCIENCE, 10.
author keywords: aging; age-related disease; geriatric; phenotype; resilience
TL;DR:
A phenotypic frailty instrument for companion dogs, utilizing components that are easily collected by owners, or in the general practice setting, is proposed, and factors that will be included, and the data from the Dog Aging Project that inform each domain are elaborate.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
2. Zero Hunger
(Web of Science)
3. Good Health and Well-being
(Web of Science)
5. Gender Equality
(Web of Science)
Sources: Web Of Science, NC State University Libraries
Added: July 19, 2023
2023 journal article
Activity patterns are associated with fractional lifespan, memory, and gait speed in aged dogs
SCIENTIFIC REPORTS, 13(1).
MeSH headings : Humans; Dogs; Animals; Alzheimer Disease; Longevity; Walking Speed; Gait; Cognition; Cognitive Dysfunction; Aging / psychology; Pain
TL;DR:
It is found that activity patterns in dogs are associated with fractional lifespan and working memory, and dogs with higher on/off leash gait speed are more active in the afternoon of weekdays.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: ORCID, Web Of Science, NC State University Libraries
Added: February 19, 2023
2023 article
Age-associated changes in electroretinography measures in companion dogs
Salzman, M. M., Merten, N., Panek, W. K., Fefer, G., Mondino, A., Westermeyer, H. D., … Mowat, F. M. (2023, June 11). DOCUMENTA OPHTHALMOLOGICA, Vol. 6.
author keywords: Translational model; Aging; Retina; ERG; Canine; Anxiolytic
TL;DR:
Consideration of anxiolytic medication use should be made when conducting ERG studies in dogs, as aged companion dogs have slower and reduced amplitude responses in both rod- and cone-mediated ERG.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, NC State University Libraries, ORCID
Added: June 19, 2023
2023 article
Association of the FGF4L2 retrogene with fibrocartilaginous embolic myelopathy in dogs
Embersics, C., Bannasch, D., Batcher, K., Boudreau, E. C., Church, M., Miller, A., … Dickinson, P. J. (2023, November 2). JOURNAL OF VETERINARY INTERNAL MEDICINE, Vol. 11.
author keywords: canine; chondrodystrophy; FCE; fibroblast growth factor
TL;DR:
Study data based on genotypically and histopathologically defined cases support the historical observation that FCE is uncommon in chondrodystrophic dog breeds.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
14. Life Below Water
(OpenAlex)
Sources: ORCID, Web Of Science, NC State University Libraries
Added: November 27, 2023
2023 journal article
Development and validation of a sleep questionnaire, SNoRE 3.0, to evaluate sleep in companion dogs
SCIENTIFIC REPORTS, 13(1).
TL;DR:
A valid and reliable questionnaire tool is described, that can be used as a cost-effective way to monitor dog sleep in clinical settings.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
8. Decent Work and Economic Growth
(OpenAlex)
Sources: Web Of Science, NC State University Libraries
Added: October 23, 2023
2023 article
Diagnosis and management of dogs with degenerative myelopathy: A survey of neurologists and rehabilitation professionals
Bouche, T. V., Coates, J. R., Moore, S. A., Faissler, D., Rishniw, M., & Olby, N. J. (2023, August 22). JOURNAL OF VETERINARY INTERNAL MEDICINE, Vol. 8.
author keywords: amyotrophic lateral sclerosis; degenerative; rehabilitation; SOD1; spinal cord
TL;DR:
The majority of dogs diagnosed with DM have not undergone advanced imaging, the combination of history, neurological findings, and genetic testing is heavily relied upon, and continued care is often performed by rehabilitation professionals or primary veterinarians.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
Sources: Web Of Science, NC State University Libraries, ORCID
Added: September 5, 2023
2023 journal article
Longitudinal Analysis of Canine Oral Microbiome Using Whole Genome Sequencing in Aging Companion Dogs
ANIMALS, 13(24).
author keywords: oral; microbiome; canine cognitive dysfunction syndrome; Alzheimer's disease
TL;DR:
The importance of defining the oral microbiota in aged dogs with a view to understanding potential therapeutic targets is shown, with an increased fungal and bacterial alpha diversity in aging dogs over time and nearly universal oral dysbiosis.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, NC State University Libraries
Added: January 16, 2024
2023 article
MRI features can help to confirm a diagnosis of progressive myelomalacia, but may not be accurate in dogs lacking characteristic clinical signs at the time of imaging
Cordle, K. J., Seiler, G. S., Barnes, D., & Olby, N. J. (2023, January 20). VETERINARY RADIOLOGY & ULTRASOUND, Vol. 1.
author keywords: ascending-descending myelomalacia; canine; intervertebral disc disease; MRI; spinal cord injury
MeSH headings : Dogs; Animals; Retrospective Studies; Case-Control Studies; Dog Diseases / diagnostic imaging; Dog Diseases / pathology; Spinal Cord Diseases / veterinary; Intervertebral Disc Displacement / diagnostic imaging; Intervertebral Disc Displacement / veterinary; Magnetic Resonance Imaging / veterinary
TL;DR:
MRI features can support the diagnosis in dogs with clinical evidence of progressive myelomalacia, and absence of these features supports absence of PMM at time of imaging, however, their absence does not reliably differentiate dogs with imminent progressive myELomalacia from other dogs with severe deficits following intervertebral disc extrusion.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
Sources: Web Of Science, NC State University Libraries
Added: February 6, 2023
2023 journal article
Magnetic resonance imaging characteristics of atlanto-axial subluxation in 42 dogs: Analysis of joint cavity size, subluxation distance, and craniocervical junction anomalies
OPEN VETERINARY JOURNAL, 13(9), 1091–1098.
author keywords: Canine; Cervical; Congenital; Malformation; Myelopathy
TL;DR:
Dogs with clinical signs of AA subluxation were significantly more likely to have intramedullary hyperintensity at the level of compression, an increased AA joint cavity size, and increased spinal cord compression at thelevel of dens and mid-body C2, according to MRI characteristics.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, NC State University Libraries
Added: January 16, 2024
2023 article
Phenotypic and genetic aspects of hereditary ataxia in dogs
Stee, K., Van Poucke, M., Lowrie, M., Van Ham, L., Peelman, L., Olby, N., & Bhatti, S. F. M. (2023, June 21). JOURNAL OF VETERINARY INTERNAL MEDICINE, Vol. 6.
author keywords: (spino)cerebellar; canine; gene; genetic variant; multiple system degeneration; neuronal ceroid lipofuscinosis
TL;DR:
A “multifocal degenerations with predominant (spino)cerebellar component” category is proposed regrouping canine multiple system degeneration, new hereditary ataxia syndromes that do not fit in 1 of the previous categories, as well as specific neuroaxonal dystrophies and lysosomal storage diseases that cause major (Spino)Cerebellar dysfunction.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, NC State University Libraries, ORCID
Added: July 3, 2023
2023 article
Presumed pituitary apoplexy in 26 dogs: Clinical findings, treatments, and outcomes
Woelfel, C. W., Mariani, C. L., Nolan, M. W., Keenihan, E. K., Topulos, S. P., Early, P. J., … Olby, N. J. (2023, April 21). JOURNAL OF VETERINARY INTERNAL MEDICINE, Vol. 4.
author keywords: adenoma; carcinoma; endocrionopathy; hemorrhage; magnetic resonance imaging; suprasellar; survival
MeSH headings : Dogs; Animals; Pituitary Apoplexy / therapy; Pituitary Apoplexy / veterinary; Pituitary Apoplexy / diagnosis; Pituitary Neoplasms / complications; Pituitary Neoplasms / diagnostic imaging; Pituitary Neoplasms / therapy; Pituitary Neoplasms / veterinary; Retrospective Studies; Hydrocephalus / veterinary; Infarction / veterinary; Magnetic Resonance Imaging / veterinary; Dog Diseases / diagnostic imaging; Dog Diseases / therapy
TL;DR:
Dogs with pituitary apoplexy present with a variety of acute signs of neurological disease and inconsistent endocrine dysfunction and dogs that survive to discharge can have a favorable outcome.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
Sources: Web Of Science, NC State University Libraries, ORCID
Added: April 22, 2023
2023 journal article
Relationship between engagement with the impossible task, cognitive testing, and cognitive questionnaires in a population of aging dogs
FRONTIERS IN VETERINARY SCIENCE, 9.
author keywords: canine cognitive dysfunction syndrome; canine cognition; frustration; aging; dogs
TL;DR:
The high correlation with several cognitive measures and the ease of administration of this test makes it a useful tool in evaluating canine cognitive dysfunction syndrome, however it is unclear if increased frustration or other cognitive processes are contributing to the observed changes.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, NC State University Libraries
Added: February 6, 2023
2023 journal article
Sleep and cognition in aging dogs. A polysomnographic study
FRONTIERS IN VETERINARY SCIENCE, 10.
author keywords: NREM sleep; REM sleep; canine cognitive dysfunction syndrome; quantitative EEG; power spectrum; coherence; complexity
TL;DR:
Polysomnographic recordings in dogs can detect sleep-wakefulness cycle changes associated with dementia, and their potential clinical use to monitor the progression of canine cognitive dysfunction syndrome is evaluated.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, NC State University Libraries
Added: May 22, 2023
2023 journal article
Winning the race with aging: age-related changes in gait speed and its association with cognitive performance in dogs
FRONTIERS IN VETERINARY SCIENCE, 10.
author keywords: canine cognitive dysfunction syndrome; canine gerontology; mobility; walking speed; memory; attention
TL;DR:
Dogs' food-motivated gait speed off leash is correlated with fractional lifespan and cognitive performance in dogs, particularly in the domains of attention and working memory and proves to be a more effective indicator of age-related deterioration and cognitive decline than gaitspeed on leash.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, NC State University Libraries
Added: July 24, 2023
2022 article
A novel mutation of the CLCN1 gene in a cat with myotonia congenita: Diagnosis and treatment
Woelfel, C., Meurs, K., Friedenberg, S., DeBruyne, N., & Olby, N. J. (2022, July 11). JOURNAL OF VETERINARY INTERNAL MEDICINE, Vol. 7.
author keywords: chloride channel; electromyography; nondystrophic myotonia; phenytoin
MeSH headings : Animals; Cat Diseases / diagnosis; Cat Diseases / drug therapy; Cat Diseases / genetics; Cats; Chloride Channels / genetics; Electromyography / veterinary; Exons; Male; Mutation; Myotonia Congenita / diagnosis; Myotonia Congenita / drug therapy; Myotonia Congenita / genetics; Myotonia Congenita / veterinary
TL;DR:
Phenytoin treatment was initiated at 3 mg/kg po q24 h and resulted in long‐term improvement and is reported for the first time its successful treatment.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
Sources: Web Of Science, NC State University Libraries, ORCID
Added: July 18, 2022
2022 article
ACVIM consensus statement on diagnosis and management of acute canine thoracolumbar intervertebral disc extrusion
Olby, N. J., Olby, N., Moore, S., Brisson, B., Fenn, J., Flegel, T., … Tipold, A. (2022, July 25). JOURNAL OF VETERINARY INTERNAL MEDICINE, Vol. 7.
author keywords: dog; intervertebral disc herniation; paralysis; spinal cord injury
MeSH headings : Animals; Decompression, Surgical / veterinary; Dog Diseases / diagnosis; Dog Diseases / etiology; Dog Diseases / therapy; Dogs; Intervertebral Disc / surgery; Intervertebral Disc Displacement / diagnosis; Intervertebral Disc Displacement / therapy; Intervertebral Disc Displacement / veterinary; Prospective Studies; Retrospective Studies
TL;DR:
Recommendations include better understanding of the ideal timing for surgical decompression, expected surgical vs medical outcomes for more mildly affected dogs, impact of durotomy on locomotor outcome and development of progressive myelomalacia, and refining of postoperative care, and genetic and preventative care studies.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, NC State University Libraries, ORCID
Added: August 1, 2022
2022 journal article
Bayesian model and selection signature analyses reveal risk factors for canine atopic dermatitis
COMMUNICATIONS BIOLOGY, 5(1).
MeSH headings : Animals; Dogs / genetics; Bayes Theorem; Dermatitis, Atopic / genetics; Dermatitis, Atopic / veterinary; Risk Factors
TL;DR:
A Bayesian mixture model adapted for mapping complex traits and a cross-population extended haplotype test is applied to search for disease-associated loci and selective sweeps in four dog breeds at risk for atopic dermatitis and identifies candidate genes, including genes belonging to the same biological pathways across multiple loci, with potential relevance to the pathogenesis of canine atopy dermatitis.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: ORCID, Web Of Science, NC State University Libraries
Added: February 19, 2023
2022 journal article
Canine Geriatric Syndrome: A Framework for Advancing Research in Veterinary Geroscience
FRONTIERS IN VETERINARY SCIENCE, 9.
author keywords: aging; lifespan; healthspan; quality of life; caregiver burden
TL;DR:
A new conceptual framework for aging in dogs, the Canine Geriatric Syndrome (CGS), which consists of the multiple, interrelated physical, functional, behavioral, and metabolic changes that characterize canine aging as well as the resulting clinical manifestations, including frailty, diminished quality of life, and age-associated disease is proposed.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, NC State University Libraries
Added: November 14, 2022
2022 article
Clinical signs, MRI findings and long-term outcomes of foraminal and far lateral thoracolumbar intervertebral disc herniations in dogs
Silva, S., Guevar, J., Jose-Lopez, R., De Decker, S., Brocal, J., Fuente, C., … Gutierrez-Quintana, R. (2022, March 12). VETERINARY RECORD, Vol. 3.
MeSH headings : Animals; Dog Diseases / diagnostic imaging; Dog Diseases / etiology; Dog Diseases / surgery; Dogs; Intervertebral Disc / diagnostic imaging; Intervertebral Disc / pathology; Intervertebral Disc Displacement / complications; Intervertebral Disc Displacement / diagnostic imaging; Intervertebral Disc Displacement / surgery; Intervertebral Disc Displacement / veterinary; Lameness, Animal / etiology; Lumbar Vertebrae / diagnostic imaging; Magnetic Resonance Imaging / veterinary; Pain / etiology; Pain / veterinary; Retrospective Studies; Thoracic Vertebrae / diagnostic imaging
TL;DR:
Although much less frequently recognised than herniation affecting the vertebral canal, foraminal and far lateral thoracolumbar intervertebral disc herniations should be considered in the differential diagnosis list of chondrodystrophic dogs presenting with pain and pelvic limb lameness.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
Sources: Web Of Science, NC State University Libraries, ORCID
Added: March 28, 2022
2022 article
Developing a predictive model for spinal shock in dogs with spinal cord injury
McBride, R., Parker, E., Garabed, R. B., Olby, N. J., Tipold, A., Stein, V. M., … Moore, S. A. (2022, January 10). JOURNAL OF VETERINARY INTERNAL MEDICINE, Vol. 1.
author keywords: fibrocartilaginous infarct; herniation; intervertebral disc disease; neurology; spinal cord disease; spinal shock
MeSH headings : Animals; Dog Diseases / diagnosis; Dogs; Humans; Intervertebral Disc Displacement / veterinary; Paraplegia / veterinary; Spinal Cord / pathology; Spinal Cord Diseases / veterinary; Spinal Cord Injuries / complications; Spinal Cord Injuries / diagnosis; Spinal Cord Injuries / veterinary
TL;DR:
A formula, as developed by the present study and after external validation, could be useful for assisting clinicians in determining the likelihood of spinal shock in various clinical scenarios and aid in diagnostic planning.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, NC State University Libraries, ORCID
Added: January 18, 2022
2022 article
Electroencephalographic Signatures of Canine Cognitive Dysfunction
Mondino, A., Gutiérrez, M., González, C., Mateos, D., Torterolo, P., Olby, N., & Delucchi, L. (2022, February 1).
TL;DR:
Electroencephalogram findings specific to AD are described and demonstrated that, quantitative EEG can detect differences between normal dogs and dogs with CCD, and reinforce the CCD as a translational model of AD.
(via Semantic Scholar)
Source: ORCID
Added: February 19, 2023
2022 journal article
Electroencephalographic signatures of dogs with presumptive diagnosis of canine cognitive dysfunction
RESEARCH IN VETERINARY SCIENCE, 150, 36–43.
author keywords: Aging; Alzheimer'sdisease; Onehealth; Cognition
MeSH headings : Animals; Cognition Disorders / diagnosis; Cognition Disorders / psychology; Cognitive Dysfunction / diagnosis; Dog Diseases / diagnosis; Dogs; Electroencephalography / veterinary; Humans; Neurodegenerative Diseases / veterinary; Quality of Life
TL;DR:
It is demonstrated that quantitative EEG analysis could aid the diagnosis of CCD, and reinforce the CCD as a translational model of early AD.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, NC State University Libraries
Added: August 15, 2022
2022 journal article
Novel subcutaneous cytarabine infusion with the Omnipod system in dogs with meningoencephalomyelitis of unknown etiology
AMERICAN JOURNAL OF VETERINARY RESEARCH, 83(9).
MeSH headings : Animals; Area Under Curve; Chromatography, High Pressure Liquid / veterinary; Cytarabine / therapeutic use; Dogs; Half-Life; Humans; Infusions, Intravenous / veterinary; North Carolina
TL;DR:
An SC continuous-rate infusion of cytarabine via the Omnipod system is feasible in dogs and was able to achieve a steady-state concentration of more than 1 μg/mL 4 to 10 hours postinitiation of cyTarabine and a Cmax of 7,510 ng/mL, comparable to values reported previously with IV continuous- rate infusion administration in healthy research Beagles and dogs with meningoencephalomyelitis of unknown etiology.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, NC State University Libraries
Added: August 1, 2022
2022 article
Relationship between hearing, cognitive function, and quality of life in aging companion dogs
Fefer, G., Khan, M. Z., Panek, W. K., Case, B., Gruen, M. E., & Olby, N. J. (2022, August 6). JOURNAL OF VETERINARY INTERNAL MEDICINE, Vol. 8.
author keywords: canine cognitive dysfunction syndrome; CCDS; cognitive testing; dementia; presbycusis
MeSH headings : Aging; Animals; Cognition; Dementia / epidemiology; Dog Diseases; Dogs; Hearing; Humans; Pets; Presbycusis / epidemiology; Presbycusis / veterinary; Prospective Studies; Quality of Life
TL;DR:
Presbycusis negatively alters owner‐pet interactions and is associated with poor executive performance and owner‐assessed dementia severity, and in multivariate analysis, higher CADES score was associated with worse hearing.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
1. No Poverty
(OpenAlex)
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, NC State University Libraries, ORCID
Added: August 22, 2022
2022 journal article
Static posturography as a novel measure of the effects of aging on postural control in dogs
PLOS ONE, 17(7).
Ed(s): R. Evans
MeSH headings : Acceleration; Aging; Animals; Arthralgia; Dogs; Postural Balance; Reproducibility of Results
TL;DR:
It is found that pressure sensitive walkway systems are a reliable tool to evaluate postural sway in dogs; and that postural swayed is affected by morphometric parameters and increases with age and joint pain.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, NC State University Libraries, ORCID
Added: September 12, 2022
2022 journal article
Stereotactic radiotherapy (10 Gy X 3) for canine nonlymphomatous intranasal tumors is associated with prolonged survival and minimal risk of severe radiotoxicity
JAVMA-JOURNAL OF THE AMERICAN VETERINARY MEDICAL ASSOCIATION, 260(12), 1496–1506.
MeSH headings : Dogs; Animals; Retrospective Studies; Dog Diseases / surgery; Quality of Life; Radiosurgery / methods; Radiosurgery / veterinary; Chondrosarcoma / veterinary; Bone Neoplasms / veterinary; Death; Treatment Outcome
TL;DR:
Oncologic outcomes following administration of a uniform stereotactic radiotherapy protocol for canine intranasal tumors are described and any clinical or dosimetric factors were predictive of event-free or overall survival time (EFST or OST) are identified.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, NC State University Libraries
Added: February 13, 2023
2022 journal article
Use of Cognitive Testing, Questionnaires, and Plasma Biomarkers to Quantify Cognitive Impairment in an Aging Pet Dog Population
JOURNAL OF ALZHEIMERS DISEASE, 87(3), 1367–1378.
author keywords: Blood biomarkers; canine cognitive dysfunction syndrome; CCDS; cognitive testing; dementia; neurofilament light chain; NfL
TL;DR:
It is suggested that a multi-dimensional approach using a combination of questionnaires, specific cognitive tests, and pNfL concentration can be used to quantify cognitive decline in aging pet dogs.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
10. Reduced Inequalities
(OpenAlex)
Sources: Web Of Science, NC State University Libraries
Added: June 20, 2022
2021 journal article
A CTSA One Health Alliance (COHA) survey of clinical trial infrastructure in North American veterinary institutions
BMC VETERINARY RESEARCH, 17(1).
MeSH headings : Animals; Clinical Trials, Veterinary as Topic; One Health; Research / economics; Research / statistics & numerical data; Schools, Veterinary / economics; Schools, Veterinary / statistics & numerical data; Surveys and Questionnaires
TL;DR:
An electronic survey of North American Veterinary Colleges regarding practices in veterinary clinical trial review, approval, conduct, and support was conducted in order to identify opportunities to leverage existing resources and develop new ones to enhance the impact of veterinary and translational health research.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, NC State University Libraries
Added: March 15, 2021
2021 journal article
A novel missense mutation of the NAT10 gene in a juvenile Schnauzer dog with chronic respiratory tract infections
JOURNAL OF VETERINARY INTERNAL MEDICINE, 35(3), 1542–1546.
author keywords: ciliary dysplasia; congenital; genetics; microtubule; pneumonia; whole genome sequencing
MeSH headings : Animals; Dog Diseases / genetics; Dogs; Male; Mutation; Mutation, Missense; Respiratory Tract Infections / genetics; Respiratory Tract Infections / veterinary; Whole Genome Sequencing / veterinary
TL;DR:
W Whole genome sequencing discovered a deleterious missense A/C mutation within the NAT10 gene, a gene essential for microtubule acetylation, appropriate ciliary development, and cytokinesis, suggesting a pathophysiological mechanism for this dog and highlighting an associated mutation or possible novel genetic cause of chronic respiratory infections in dogs.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
Sources: Web Of Science, NC State University Libraries, ORCID
Added: March 29, 2021
2021 article
ALSUntangled #63: ketogenic diets
Bedlack, R., Barkhaus, P. E., Barnes, B., Beauchamp, M., Bertorini, T., Bromberg, M. B., … Wills, A.-M. (2021, October 13). AMYOTROPHIC LATERAL SCLEROSIS AND FRONTOTEMPORAL DEGENERATION, Vol. 10.
author keywords: Ketone; ketogenic diet; alsuntangled; mitochondria; transgenic animals; therapy
MeSH headings : Mice; Animals; Humans; Diet, Ketogenic; Amyotrophic Lateral Sclerosis
TL;DR:
It is concluded that there is yet not enough data to recommend ketogenic diets for patients with ALS, especially in light of the many side effects these can have.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
7. Affordable and Clean Energy
(OpenAlex)
Sources: Web Of Science, NC State University Libraries
Added: November 1, 2021
2021 journal article
Association between filum terminale internum length and pain in Cavalier King Charles spaniels with and without syringomyelia
JOURNAL OF VETERINARY INTERNAL MEDICINE, 35(1), 363–371.
author keywords: Chiari-like malformation; conus medullaris; dural sac; morphometry; tethered cord
MeSH headings : Animals; Cauda Equina / diagnostic imaging; Dog Diseases; Dogs; Magnetic Resonance Imaging / veterinary; Pain / veterinary; Prospective Studies; Reproducibility of Results; Syringomyelia / diagnostic imaging; Syringomyelia / veterinary
TL;DR:
Painful CKCS without SM have decreased distance between the termination of the spinal cord and dural sac, suggesting a shorter FTIL, and more caudal spinal cord termination is associated with development of lumbar SM.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, NC State University Libraries, ORCID
Added: February 1, 2021
2021 journal article
Canine junctional epidermolysis bullosa due to a novel mutation in LAMA3 with severe upper respiratory involvement
VETERINARY DERMATOLOGY, 32(4), 379-+.
MeSH headings : Animals; Australia; Cattle; Dog Diseases / genetics; Dogs; Epidermolysis Bullosa, Junctional / genetics; Epidermolysis Bullosa, Junctional / veterinary; Laminin / genetics; Mutation, Missense; Nail Diseases / genetics; Nail Diseases / veterinary
TL;DR:
A novel variant in LAMA3 caused a generalized and severe phenotype of JEB with an unique clinical presentation of upper airway obstruction in a litter of puppies with severe upper respiratory involvement.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
Sources: Web Of Science, NC State University Libraries, ORCID
Added: July 19, 2021
2021 article
Editorial: Canine Intervertebral Disc Disease: The Current State of Knowledge
Olby, N. J., & Tipold, A. (2021, March 16). FRONTIERS IN VETERINARY SCIENCE, Vol. 8.
author keywords: intervertebral disc disease; canine; spinal cord injury; disc extrusion; disc degeneration
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, NC State University Libraries
Added: April 5, 2021
2021 journal article
Effect of Sedation on the Neurological Examination of the Patellar and Withdrawal Reflexes in Healthy Dogs
FRONTIERS IN VETERINARY SCIENCE, 8.
author keywords: sedation; withdrawal reflex; dexmedetomidine; patellar reflex; neurological exam
TL;DR:
Sedation does not affect the evaluation of the withdrawal reflex on any limb but improves the visualization of the patellar reflex in this group of neurologically normal dogs.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
Sources: Web Of Science, NC State University Libraries
Added: June 10, 2021
2021 journal article
Levetiracetam-responsive paroxysmal exertional dyskinesia in a Welsh Terrier
JOURNAL OF VETERINARY INTERNAL MEDICINE, 35(2), 1093–1097.
author keywords: movement disorder; paroxysmal dyskinesia; treatment; Welsh Terrier
MeSH headings : Animals; Anticonvulsants / therapeutic use; Chorea / veterinary; Diazepam / therapeutic use; Dog Diseases / drug therapy; Dogs; Dystonic Disorders / veterinary; Female; Levetiracetam / therapeutic use
TL;DR:
Although the pathophysiology of PED is not fully understood, the clinical presentation and the positive response to antiepileptic therapy highlight the overlap between disease pathways in epilepsy and PED in dogs.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
Sources: Web Of Science, NC State University Libraries, ORCID
Added: March 15, 2021
2021 journal article
Outcomes and prognostic indicators in 59 paraplegic medium to large breed dogs with extensive epidural hemorrhage secondary to thoracolumbar disc extrusion
VETERINARY SURGERY, 50(3), 527–536.
MeSH headings : Animals; Cohort Studies; Dog Diseases / diagnosis; Dog Diseases / surgery; Dogs; Female; Hematoma, Epidural, Spinal / complications; Hematoma, Epidural, Spinal / surgery; Hematoma, Epidural, Spinal / veterinary; Intervertebral Disc Degeneration / complications; Intervertebral Disc Degeneration / surgery; Intervertebral Disc Degeneration / veterinary; Laminectomy / statistics & numerical data; Laminectomy / veterinary; Male; Paraplegia / diagnosis; Paraplegia / surgery; Paraplegia / veterinary; Prognosis; Recovery of Function; Retrospective Studies; Species Specificity; Treatment Outcome; Walking
TL;DR:
Paraplegic medium to large breed dogs with DEEH have a less favorable outcome after surgical decompression than paraplegic dogs with TL-IVDE, and loss of pain perception and increased HASTEi are associated with a poor outcome, while more extensive decompression improves outcome.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
Sources: Web Of Science, NC State University Libraries
Added: March 8, 2021
2021 article
Subaxial cervical articular process subluxation and dislocation: Cervical locked facet injuries in dogs
Woelfel, C. W., Bray, K. Y., Early, P. J., Mariani, C. L., & Olby, N. J. (2021, November 24). VETERINARY SURGERY, Vol. 11.
MeSH headings : Animals; Cervical Vertebrae; Dogs; Joint Dislocations / veterinary; Neck; Retrospective Studies
TL;DR:
In these dogs, locked facet injuries affected the caudal cervical vertebrae in small breeds and could be identified on imaging through the presence of dorsal displacement of a cranial articular process.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
Sources: Web Of Science, NC State University Libraries
Added: December 6, 2021
2021 journal article
Sustained Gaze Is a Reliable In-home Test of Attention for Aging Pet Dogs
FRONTIERS IN VETERINARY SCIENCE, 8.
author keywords: Canine Cognitive Dysfunction Syndrome; cognitive testing; dementia; executive function; attention; cognitive impairment
TL;DR:
It is concluded that owners can perform the sustained gaze test at home and that data generated are reliable and correlate to CADES, a validated measure of dementia.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, NC State University Libraries
Added: January 24, 2022
2021 article
Vascular endothelial growth factor concentrations in the cerebrospinal fluid of dogs with neoplastic or inflammatory central nervous system disorders
Mariani, C. L., Niman, Z. E., Boozer, L. B., Ruterbories, L. K., Early, P. J., Munana, K. R., & Olby, N. J. (2021, June 9). JOURNAL OF VETERINARY INTERNAL MEDICINE, Vol. 6.
author keywords: biomarker; brain tumor; meningoencephalitis; meningomyelitis
MeSH headings : Animals; Case-Control Studies; Central Nervous System Diseases / veterinary; Cerebrospinal Fluid; Dog Diseases; Dogs; Hospitals, Animal; Hospitals, Teaching; Vascular Endothelial Growth Factor A
TL;DR:
Concentrations of VEGF in CSF are higher in dogs with central nervous system (CNS) neoplasia compared to those with meningoencephalomyelitis and other neurologic disorders and may serve as a marker of neoplastic and inflammatory CNS disorders relative to other conditions.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
Sources: Web Of Science, NC State University Libraries, ORCID
Added: June 10, 2021
2020 journal article
A mutation in MTM1 causes X-Linked myotubular myopathy in Boykin spaniels
Neuromuscular Disorders, 30(5), 353–359.
author keywords: Canine; Centronuclear myopathy; Myotubularin myopathy
MeSH headings : Animals; Dogs; Male; Myopathies, Structural, Congenital / genetics; Myopathies, Structural, Congenital / pathology; Myopathies, Structural, Congenital / physiopathology; Pedigree; Phenotype; Protein Tyrosine Phosphatases, Non-Receptor / genetics
TL;DR:
The purpose of this study was to report the findings of clinical and genetic evaluation of a 3-month old male Boykin spaniel that presented with progressive weakness that causes a severe form of X-linked myotubular myopathy, comparable to the human counterpart.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, NC State University Libraries, Crossref, ORCID
Added: June 29, 2020
2020 review
Ambulation in Dogs With Absent Pain Perception After Acute Thoracolumbar Spinal Cord Injury
[Review of ]. FRONTIERS IN VETERINARY SCIENCE, 7.
author keywords: spinal walking; deep pain negative; intervertebral disc herniation; canine; locomotion; gait generation
TL;DR:
Improved understanding of the mechanisms of gait generation and plasticity of the surviving tissue after injury might pave the way for further treatment options and enhanced outcomes in severely injured dogs.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
Sources: Web Of Science, NC State University Libraries
Added: October 19, 2020
2020 journal article
An update on hemilaminectomy of the cranial thoracic spine: review of 6 Cases
Open Veterinary Journal, 10(1), 16–21.
Source: NC State University Libraries
Added: September 20, 2020
2020 journal article
Association between anesthesia duration and outcome in dogs with surgically treated acute severe spinal cord injury caused by thoracolumbar intervertebral disk herniation
Journal of Veterinary Internal Medicine.
author keywords: canine; extrusion; hemilaminectomy; prognosis; surgery
MeSH headings : Anesthesia / adverse effects; Anesthesia / veterinary; Animals; Cohort Studies; Dog Diseases / surgery; Dogs; Female; Intervertebral Disc Degeneration / veterinary; Intervertebral Disc Displacement / veterinary; Laminectomy / veterinary; Male; Operative Time; Pain / veterinary; Paraplegia / rehabilitation; Paraplegia / surgery; Paraplegia / veterinary; Retrospective Studies; Spinal Cord Injuries / surgery; Spinal Cord Injuries / veterinary; Treatment Outcome; Walking
TL;DR:
A negative association between increased duration of anesthesia and outcome in dogs with absent pain perception treated surgically for acute thoracolumbar intervertebral disk herniation is supported.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
1. No Poverty
(OpenAlex)
3. Good Health and Well-being
(Web of Science)
Sources: Crossref, NC State University Libraries, ORCID
Added: May 18, 2020
2020 review
Bladder and Bowel Management in Dogs With Spinal Cord Injury
[Review of ]. FRONTIERS IN VETERINARY SCIENCE, 7.
author keywords: bladder; urinary and fecal incontinence; spinal cord injury; autonomic; dysfunction; canine; dog; sacral implant
TL;DR:
The physiology of micturition and defecation in dogs is proposed to briefly remind the reader and the bladder and gastrointestinal clinical signs associated with sacral lesions and supra-sacral lesions are presented, largely in the context of intervertebral disc herniation.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, NC State University Libraries
Added: December 11, 2020
2020 journal article
Cerebrospinal fluid lactate concentrations in dogs with seizure disorders
Journal of Veterinary Internal Medicine.
author keywords: acute repetitive seizures; biomarker; cluster seizures; epilepsy; status epilepticus
MeSH headings : Animals; Dog Diseases; Dogs; Epilepsy / veterinary; Humans; Lactic Acid; Seizures / veterinary; Status Epilepticus / veterinary
TL;DR:
Cerebrospinal fluid lactate concentration is minimally affected by seizure activity in dogs and increased concentrations are more likely associated with the underlying disease process.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
Source: ORCID
Added: November 3, 2020
2020 review
Classification of Intervertebral Disc Disease
[Review of ]. FRONTIERS IN VETERINARY SCIENCE, 7.
author keywords: IVD; chondrodystrophy; degeneration; Hansen; extrusion; protrusion
TL;DR:
An up to date overview of both historical and current systems of IVDD classification is provided, highlighting the important findings and controversies underpinning them.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, NC State University Libraries
Added: November 9, 2020
2020 review
Clinical Trial Design-A Review-With Emphasis on Acute Intervertebral Disc Herniation
[Review of ]. FRONTIERS IN VETERINARY SCIENCE, 7.
author keywords: explanatory; pragmatic; durotomy; glyburide; spinal cord injury
TL;DR:
In this review another key trial design decision—that between pragmatic and explanatory approaches—is highlighted and used as a theme to illustrate the close relationship between trial objective and design.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, NC State University Libraries
Added: October 12, 2020
2020 journal article
Comparison of Gait Assessment Scales in Dogs with Spinal Cord Injury due to Intervertebral Disc Herniation
Journal of Neurotrauma, 1.
author keywords: intervertebral disc herniation; outcome measure; paralysis; reliability
MeSH headings : Animals; Dogs; Gait / physiology; Gait Analysis / methods; Gait Analysis / standards; Intervertebral Disc Displacement / complications; Intervertebral Disc Displacement / physiopathology; Intervertebral Disc Displacement / therapy; Physical Therapy Modalities; Spinal Cord Injuries / etiology; Spinal Cord Injuries / physiopathology; Spinal Cord Injuries / therapy; Walking / physiology
TL;DR:
It is concluded that gait in dogs with SCI can be scored reliably following training and a variety of different gait scales can be used in multicenter trials to capture outcome in different ways.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Crossref, NC State University Libraries
Added: July 7, 2020
2020 journal article
Continuous rate infusion of midazolam as emergent treatment for seizures in dogs
Journal of Veterinary Internal Medicine.
author keywords: acute repetitive seizures; anticonvulsant; benzodiazepine; canine; cluster seizures; epilepsy; status epilepticus
MeSH headings : Animals; Anticonvulsants / adverse effects; Dog Diseases / drug therapy; Dogs; Hospitals, Animal; Hospitals, Teaching; Midazolam / therapeutic use; Retrospective Studies; Seizures / drug therapy; Seizures / veterinary
TL;DR:
Midazolam CRI is apparently safe and might be an effective treatment in dogs with CS or SE, and dogs with idiopathic/unknown epilepsy were more likely to survive than those with structural epilepsy.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
Source: ORCID
Added: December 17, 2020
2020 review
Current Approaches to the Management of Acute Thoracolumbar Disc Extrusion in Dogs
[Review of ]. FRONTIERS IN VETERINARY SCIENCE, 7.
author keywords: dog; interveterbral disc; intervertebral disc disease; hemilaminectomy; spinal cord injury; hansen type I
TL;DR:
There is no evidence to support treatment of the 48 h time point as a cut off beyond which it becomes impossible for dogs to achieve locomotor recovery, and recommendations for standard care can be made in some areas, particularly with respect to surgical decompression.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
Sources: Web Of Science, NC State University Libraries
Added: October 26, 2020
2020 journal article
Influence of Duration of Injury on Diffusion Tensor Imaging in Acute Canine Spinal Cord Injury
JOURNAL OF NEUROTRAUMA, 37(21), 2261–2267.
author keywords: dog; fractional anisotropy; imaging biomarker; intervertebral disc herniation; mean diffusivity
MeSH headings : Animals; Diffusion Tensor Imaging / methods; Dogs; Intervertebral Disc Displacement / diagnostic imaging; Intervertebral Disc Displacement / pathology; Intervertebral Disc Displacement / veterinary; Spinal Cord Injuries / diagnostic imaging; Spinal Cord Injuries / pathology; Spinal Cord Injuries / veterinary; Time Factors
TL;DR:
Investigating the impact of duration of injury on DTI indices in dogs with acute, spontaneous SCI due to thoracolumbar intervertebral disc herniation and explore associations with clinical severity found MD might differentiate injury severity in the acute setting and be worthy of development as an imaging biomarker.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
Sources: Web Of Science, NC State University Libraries
Added: August 31, 2020
2020 journal article
Intervertebral disc disease and aortic thromboembolism are the most common causes of acute paralysis in dogs and cats presenting to an emergency clinic
VETERINARY RECORD, 187(10).
MeSH headings : Animals; Cat Diseases / epidemiology; Cats; Dog Diseases / epidemiology; Dogs; Emergency Service, Hospital; Female; Intervertebral Disc Degeneration / epidemiology; Intervertebral Disc Degeneration / veterinary; Intervertebral Disc Displacement / epidemiology; Intervertebral Disc Displacement / veterinary; Male; North Carolina / epidemiology; Paralysis / etiology; Paralysis / veterinary; Prevalence; Records / veterinary; Thromboembolism / epidemiology; Thromboembolism / veterinary
TL;DR:
IVDD and ATE are the overwhelming causes of acute paralysis in dogs and cats, respectively, with approximately 28% of dogs and 40 per cent of cats having a different diagnosis.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, NC State University Libraries, ORCID
Added: February 15, 2021
2020 journal article
Long-term postoperative pain evaluation in dogs with thoracolumbar intervertebral disk herniation after hemilaminectomy
JOURNAL OF VETERINARY INTERNAL MEDICINE, 34(4), 1547–1555.
author keywords: algometry; mechanical thresholds; neuropathic pain; postoperative pain; spinal cord injury
MeSH headings : Animals; Dog Diseases / surgery; Dogs; Female; Intervertebral Disc Degeneration / surgery; Intervertebral Disc Displacement / surgery; Laminectomy / adverse effects; Laminectomy / veterinary; Male; Neuralgia / veterinary; Pain Measurement / veterinary; Pain, Postoperative / veterinary; Prospective Studies; Sensory Thresholds; Spinal Cord Injuries / surgery; Spinal Cord Injuries / veterinary
TL;DR:
Improving long‐term pain assessment of SCI dogs is important for offering treatment options and advising owners, and Mechanical sensory thresholds normalize by 6 months after surgery in most dogs with SCI.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
Sources: Web Of Science, NC State University Libraries, ORCID
Added: June 29, 2020
2020 journal article
Minimally invasive spine surgery in dogs: Evaluation of the safety and feasibility of a thoracolumbar approach to the spinal cord
Veterinary Surgery, 49, O76–O85.
MeSH headings : Animals; Dogs / surgery; Feasibility Studies; Female; Male; Minimally Invasive Surgical Procedures / methods; Minimally Invasive Surgical Procedures / veterinary; Orthopedic Procedures / veterinary; Pain, Postoperative / veterinary; Prospective Studies; Plastic Surgery Procedures; Spinal Cord / surgery; Thoracic Vertebrae / surgery; Treatment Outcome
TL;DR:
Minimally invasive spine surgery was a safe and feasible technique to access the thoracolumbar vertebral canal and the ventral aspect of the spinal cord in dogs and supported postoperative pain benefits.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, NC State University Libraries, Crossref
Added: February 17, 2020
2020 journal article
Plasma Amyloid Beta Concentrations in Aged and Cognitively Impaired Pet Dogs
MOLECULAR NEUROBIOLOGY, 58(2), 483–489.
Contributors: W. Panek n , D. Murdoch *, M. Gruen n , F. Mowat n, R. Marek* & n
author keywords: Canine; Cognitive dysfunction; Alzheimer's disease; CDS; Amyloid beta 42; Amyloid beta 40
MeSH headings : Aging / blood; Amyloid beta-Peptides / blood; Animals; Cognitive Dysfunction / blood; Dogs / blood; Female; Male; Pets / blood
TL;DR:
The findings suggest the dynamics of canine plasma amyloid concentrations are analogous to that found in aging humans with and without AD.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, ORCID, NC State University Libraries
Added: October 12, 2020
2020 journal article
Plasma Neurofilament Light Chain as a Translational Biomarker of Aging and Neurodegeneration in Dogs
MOLECULAR NEUROBIOLOGY, 57(7), 3143–3149.
Contributors: W. Panek n , M. Gruen n , D. Murdoch *, R. Marek*, A. Stachel n, F. Mowat*, K. Saker n, n
author keywords: Canine; Cognitive dysfunction; Alzheimer's disease; Amyotrophic lateral sclerosis; Degenerative myelopathy
TL;DR:
This work identified plasma NfL as a key clinical index of neuro-aging and neurodegeneration in pet dogs using an ultrasensitive single-molecule array assay to measure plasma concentrations and found it increases in an age-dependent manner and is significantly elevated in dogs diagnosed with Neurodegenerative disease.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, NC State University Libraries, ORCID
Added: July 13, 2020
2020 review
Prognostic Factors in Canine Acute Intervertebral Disc Disease
[Review of ]. FRONTIERS IN VETERINARY SCIENCE, 7.
author keywords: paraplegia; ambulation; dog; pain perception; spinal cord injury; acute intervertebral disc extrusion; acute non-compressive nucleus pulposus extrusion
TL;DR:
Cross-sectional area and length of T2 hyperintensity and loss of HASTE signal on MRI have been associated with outcome and future developments in plasma and imaging biomarkers will assist in accurate prognostication and optimization of patient management.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
Sources: Web Of Science, NC State University Libraries
Added: January 4, 2021
2020 journal article
Traumatic skull fractures in dogs and cats: A comparative analysis of neurological and computed tomographic features
JOURNAL OF VETERINARY INTERNAL MEDICINE, 34(5), 1975–1985.
author keywords: canine; computed tomography; feline; skull fractures
MeSH headings : Animals; Cat Diseases / diagnostic imaging; Cats; Dog Diseases / diagnostic imaging; Dogs; Retrospective Studies; Skull / diagnostic imaging; Skull Fractures / diagnostic imaging; Skull Fractures / veterinary; Tomography, X-Ray Computed / veterinary
TL;DR:
The cranial vault fractures were associated with neurological deficits and worse survival, and the presence of TSF alone should not be considered a negative prognostic factor because most affected animals survived the first week.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
Sources: Web Of Science, NC State University Libraries
Added: August 3, 2020
2019 journal article
A QIL1 Variant Associated with Ventricular Arrhythmias and Sudden Cardiac Death in the Juvenile Rhodesian Ridgeback Dog
Genes, 10(2), 168.
author keywords: QIL1; Rhodesian ridgeback; arrhythmia; mitochondrial cristae
MeSH headings : Animals; Death, Sudden, Cardiac / veterinary; Dog Diseases / genetics; Dog Diseases / pathology; Dogs; Female; Male; Mitochondria, Muscle / metabolism; Mitochondria, Muscle / ultrastructure; Mitochondrial Proteins / genetics; Mutation; Tachycardia, Ventricular / genetics; Tachycardia, Ventricular / pathology; Tachycardia, Ventricular / veterinary
TL;DR:
A natural animal model of mitochondrial cardiomyopathy provides a large animal model with which to study the development and progression of disease as well as genotypic phenotypic relationships.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
7. Affordable and Clean Energy
(OpenAlex)
Sources: Web Of Science, NC State University Libraries, Crossref, ORCID
Added: March 25, 2019
2019 journal article
A missense variant in the titin gene in Doberman pinscher dogs with familial dilated cardiomyopathy and sudden cardiac death
Human Genetics, 138(5), 515–524.
MeSH headings : Amino Acid Sequence; Animals; Base Sequence; Cardiomyopathy, Dilated / genetics; Cardiomyopathy, Dilated / veterinary; Connectin / genetics; Death, Sudden, Cardiac / etiology; Death, Sudden, Cardiac / veterinary; Disease Models, Animal; Dogs; Female; Genetic Predisposition to Disease / genetics; Male; Mutation, Missense / genetics; Protein Kinases / genetics; Whole Genome Sequencing
TL;DR:
The dog provides a large animal model of familial dilated cardiomyopathy and is an excellent model to improve the understanding of the genotypic phenotypic relationships, penetrance, expression and the pathophysiology of variants in the titin gene.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, NC State University Libraries, Crossref
Added: June 17, 2019
2019 journal article
Cerebrospinal fluid lactate in dogs with inflammatory central nervous system disorders
Journal of Veterinary Internal Medicine, 33(6), 2701–2708.
author keywords: canine; encephalitis; meningitis; meningo; meningoencephalitis; myelitis
MeSH headings : Animals; Dog Diseases / cerebrospinal fluid; Dogs; Inflammation / cerebrospinal fluid; Inflammation / veterinary; Lactic Acid / cerebrospinal fluid; Meningoencephalitis / cerebrospinal fluid; Meningoencephalitis / drug therapy; Meningoencephalitis / pathology; Meningoencephalitis / veterinary; Reference Values; Retrospective Studies; Steroids / therapeutic use
TL;DR:
Cerebrospinal fluid lactate concentrations could serve as a rapid biomarker of inflammatory CNS disease in dogs as well as humans with inflammatory central nervous system disorders.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
Sources: Crossref, NC State University Libraries, ORCID
Added: September 25, 2019
2019 journal article
Clinical characteristics, breed differences, and quality of life in North American dogs with acute steroid‐responsive meningitis‐arteritis
Journal of Veterinary Internal Medicine, 33(4), 1719–1727.
author keywords: aseptic meningitis; CSF analysis; immune-mediated disease; treatment response
MeSH headings : Animals; Arteritis / cerebrospinal fluid; Arteritis / drug therapy; Arteritis / veterinary; Canada / epidemiology; Dog Diseases / cerebrospinal fluid; Dog Diseases / drug therapy; Dog Diseases / pathology; Dogs; Female; Genetic Predisposition to Disease; Male; Meningitis / cerebrospinal fluid; Meningitis / drug therapy; Meningitis / veterinary; Neutrophils; Quality of Life; Recurrence; Retrospective Studies; Steroids / administration & dosage; Steroids / adverse effects; Steroids / therapeutic use; Surveys and Questionnaires; United States / epidemiology
TL;DR:
Golden Retrievers and Wirehaired Pointing Griffons should be considered among the breeds recognized to develop SRMA, and treatment with higher corticosteroid dosages is correlated with more severe adverse effects and worse QoL.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
Sources: Crossref, NC State University Libraries, ORCID
Added: June 8, 2019
2019 journal article
Co-infection with Bartonella henselae and Sarcocystis sp. in a 6-year-old male neutered domestic longhair cat with progressive multifocal neurological signs
Veterinary Quarterly, 39(1), 168–173.
MeSH headings : Animals; Bartonella henselae / genetics; Bartonella henselae / isolation & purification; Cat Diseases / drug therapy; Cat Diseases / microbiology; Cat-Scratch Disease / diagnosis; Cat-Scratch Disease / drug therapy; Cats; Coinfection / microbiology; Databases, Nucleic Acid; Drug Therapy, Combination / veterinary; Male; Orchiectomy / veterinary; Sarcocystis / genetics; Sarcocystis / isolation & purification; Sarcocystosis / diagnosis; Sarcocystosis / drug therapy; Treatment Outcome
TL;DR:
Aude Castel, Natasha J. Olby, Edward B. Breitschwerdt, Brittany Thomas, Ricardo G. Maggi and G. Diane Shelton present a novel approach to cell reprograming that allows for real-time characterization of the “silent” and “active” components of E.coli.
(via Semantic Scholar)
Sources: Crossref, NC State University Libraries
Added: July 7, 2020
2019 journal article
Comparison of cerebrospinal fluid parameters from the cerebellomedullary and lumbar cisterns in 54 dogs
Canadian Veterinary Journal, 60(8), 885–888.
Source: NC State University Libraries
Added: September 20, 2020
2019 journal article
Development of a Novel Gait Analysis Tool Measuring Center of Pressure for Evaluation of Canine Chronic Thoracolumbar Spinal Cord Injury
Journal of Neurotrauma, 36(21), 3018–3025.
author keywords: center of pressure; chronic spinal cord injury; dogs; locomotion; postural control
MeSH headings : Animals; Dogs; Gait Analysis / instrumentation; Lumbar Vertebrae; Postural Balance / physiology; Spinal Cord Injuries / veterinary; Thoracic Vertebrae
TL;DR:
COP analysis and body weight support measurements offer information about post-injury locomotion and further development is needed before consideration as an outcome measure to complement validated gait analysis methods in dogs with SCI.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
Sources: Web Of Science, NC State University Libraries, Crossref
Added: June 24, 2019
2019 journal article
Genome-wide association analysis in West Highland White Terriers with atopic dermatitis
Veterinary Immunology and Immunopathology, 209, 1–6.
Contributors: C. Agler n, S. Friedenberg *, T. Olivry n , K. Meurs n & n
author keywords: Allergy; Atopic; Canine; Dogs; Genetics; GWAS; Skin
MeSH headings : Animals; Cohort Studies; Dermatitis, Atopic / genetics; Dermatitis, Atopic / veterinary; Dog Diseases / genetics; Dogs; Female; Genome-Wide Association Study / veterinary; Genotyping Techniques / veterinary; Male; Polymorphism, Single Nucleotide
TL;DR:
Atopic dermatitis in WHWT is associated with a region on CFA3 that contains several candidate genes and a homozygous variant in the F2R gene present in multiple breeds that also suffer from AD warrants further evaluation.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
15. Life on Land
(OpenAlex)
Sources: Web Of Science, NC State University Libraries, ORCID, Crossref
Added: April 15, 2019
2019 journal article
Minimally invasive microsurgical decompression of an intervertebral disc protrusion in a dog
VETERINARY SURGERY, 49, O86–O92.
MeSH headings : Animals; Decompression, Surgical / methods; Decompression, Surgical / veterinary; Dogs; Intervertebral Disc / pathology; Intervertebral Disc / surgery; Intervertebral Disc Degeneration / surgery; Intervertebral Disc Degeneration / veterinary; Intervertebral Disc Displacement / surgery; Intervertebral Disc Displacement / veterinary; Male; Microsurgery / veterinary; Neurosurgical Procedures / methods; Neurosurgical Procedures / veterinary; Retrospective Studies; Spinal Cord Compression / surgery; Spinal Cord Compression / veterinary; Treatment Outcome
TL;DR:
This case provides evidence that minimally invasive microsurgery is an effective treatment for intervertebral disc protrusion in large breed dogs and may offer benefits regarding postoperative pain and functional recovery.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, NC State University Libraries, ORCID
Added: June 22, 2020
2019 journal article
Morphometric analysis of spinal cord termination in Cavalier King Charles Spaniels
Journal of Veterinary Internal Medicine, 33(2), 717–725.
author keywords: conus medullaris; dural sac; filum terminate; syringomyelia
MeSH headings : Animals; Dog Diseases / diagnostic imaging; Dogs; Dura Mater / abnormalities; Female; Magnetic Resonance Imaging / veterinary; Male; Neural Tube Defects / diagnostic imaging; Neural Tube Defects / veterinary; Reproducibility of Results; Retrospective Studies; Spinal Cord / abnormalities; Syringomyelia / diagnostic imaging; Syringomyelia / veterinary
TL;DR:
The relationship between TL SM and possible spinal cord tethering because of a more caudal dural sac termination should be investigated.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, NC State University Libraries, Crossref, ORCID
Added: April 22, 2019
2019 journal article
Presence of cerebrospinal fluid antibodies associated with autoimmune encephalitis of humans in dogs with neurologic disease
Journal of Veterinary Internal Medicine, 33(5), 2175–2182.
author keywords: immunofluorescent assay; meningoencephalitis; MUE; NMDA receptor encephalitis
MeSH headings : Animals; Autoantibodies / cerebrospinal fluid; Central Nervous System Diseases / cerebrospinal fluid; Central Nervous System Diseases / immunology; Central Nervous System Diseases / veterinary; Dog Diseases / cerebrospinal fluid; Dog Diseases / immunology; Dogs; Female; Fluorescent Antibody Technique, Indirect / veterinary; Humans; Male; Meningoencephalitis / cerebrospinal fluid; Meningoencephalitis / immunology; Meningoencephalitis / therapy; Neurons / immunology; Receptors, N-Methyl-D-Aspartate / immunology
TL;DR:
Defining antigenic targets associated with encephalitis in dogs might allow diagnostic categorization of MUE antemortem and further evaluation of the prevalence and clinical relevance of CSF and serum antibodies to neuronal cell surface antigens is warranted.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
Sources: Crossref, NC State University Libraries, ORCID
Added: September 9, 2019
2019 journal article
Risk factors associated with progressive myelomalacia in dogs with complete sensorimotor loss following intervertebral disc extrusion: a retrospective case-control study
BMC Veterinary Research, 15(1).
author keywords: Ascending-descending myelomalacia; Spinal cord injury; Intervertebral disk disease; Paraplegia
MeSH headings : Animals; Case-Control Studies; Dog Diseases / etiology; Dog Diseases / pathology; Dog Diseases / physiopathology; Dogs; Female; Intervertebral Disc Displacement / complications; Intervertebral Disc Displacement / veterinary; Logistic Models; Male; Multivariate Analysis; Paraplegia / etiology; Paraplegia / physiopathology; Paraplegia / veterinary; Retrospective Studies; Risk Factors; Spinal Cord Diseases / etiology; Spinal Cord Diseases / pathology; Spinal Cord Diseases / physiopathology; Spinal Cord Diseases / veterinary
TL;DR:
Dogs with lumbar intumescence IVDE are at increased risk of progressive myelomalacia and timing of surgery and corticosteroid use warrant further investigations.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
Sources: Web Of Science, NC State University Libraries, Crossref, ORCID
Added: February 10, 2020
2019 journal article
The R9H phospholamban mutation is associated with highly penetrant dilated cardiomyopathy and sudden death in a spontaneous canine model
Gene, 697, 118–122.
author keywords: Canine; Phospholamban; Dilated cardiomyopathy; Sudden death; Genetic
MeSH headings : Animals; Calcium-Binding Proteins / genetics; Calcium-Binding Proteins / physiology; Cardiomyopathy, Dilated / genetics; Death, Sudden / etiology; Death, Sudden / veterinary; Dogs; Female; Genetic Predisposition to Disease / genetics; Male; Mutation / genetics; Pedigree; Polymorphism, Single Nucleotide / genetics; Sequence Analysis, DNA
TL;DR:
A spontaneous canine model of familial DCM and sudden death with the R9H mutation is described, which was highly penetrant and resulted in sudden death in comparison to a reported human family.
(via Semantic Scholar)
Sources: Crossref, NC State University Libraries
Added: September 29, 2019
2019 journal article
Time course and prognostic value of serum GFAP, pNFH, and S100β concentrations in dogs with complete spinal cord injury because of intervertebral disc extrusion
Journal of Veterinary Internal Medicine, 33(2), 726–734.
author keywords: biomarker; intervertebral disc disease; myelomalacia; prognosis
MeSH headings : Animals; Biomarkers / blood; Dogs / blood; Dogs / injuries; Glial Fibrillary Acidic Protein / blood; Intermediate Filaments / metabolism; Intervertebral Disc Degeneration / veterinary; Intervertebral Disc Displacement / veterinary; Paralysis / blood; Paralysis / veterinary; Phosphorylation; Prognosis; Prospective Studies; S100 Calcium Binding Protein beta Subunit / blood; Spinal Cord Injuries / blood; Time Factors
TL;DR:
Serum GFAP concentrations can be used to predict outcome in clinically complete SCI with an accuracy of 76.7%‐89% depending on sample timing.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
Sources: Crossref, NC State University Libraries, ORCID
Added: February 20, 2019
2018 journal article
A de novo mutation in the EXT2 gene associated with osteochondromatosis in a litter of American Staffordshire Terriers
Journal of Veterinary Internal Medicine, 32(3), 986–992.
author keywords: bone; cartilage; genetics; multiple cartilaginous exostoses; mutation; osteochondroma
MeSH headings : Animals; Cartilage / pathology; Dog Diseases / genetics; Dog Diseases / pathology; Dogs; Female; Genetic Variation / genetics; Male; Mosaicism / veterinary; N-Acetylglucosaminyltransferases / genetics; Osteochondromatosis / genetics; Osteochondromatosis / pathology; Osteochondromatosis / veterinary; Polymorphism, Single Nucleotide / genetics; Whole Genome Sequencing / veterinary
TL;DR:
The identical mutation arose de novo in a litter of American Staffordshire Terrier puppies and represents the first reported mutation associated with osteochondromatosis in dogs.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, NC State University Libraries, Crossref, ORCID
Added: August 6, 2018
2018 journal article
A randomized, blinded, prospective clinical trial of postoperative rehabilitation in dogs after surgical decompression of acute thoracolumbar intervertebral disc herniation
Journal of Veterinary Internal Medicine, 32(3), 1133–1144.
author keywords: ataxia; gait training; locomotion; plasticity; spinal cord injury
MeSH headings : Animals; Decompression, Surgical / methods; Decompression, Surgical / veterinary; Dog Diseases / surgery; Dogs; Female; Intervertebral Disc Displacement / rehabilitation; Intervertebral Disc Displacement / surgery; Intervertebral Disc Displacement / veterinary; Lumbar Vertebrae / surgery; Male; Postoperative Care / veterinary; Recovery of Function; Thoracic Vertebrae / surgery
TL;DR:
Early postoperative rehabilitation after surgery for TL‐IVDH is safe but doesn't improve rate or level of recovery in dogs with incomplete SCI.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
Sources: Web Of Science, NC State University Libraries, Crossref, ORCID
Added: August 6, 2018
2018 journal article
Deafness and vestibular dysfunction in a Doberman Pinscher puppy associated with a mutation in the PTPRQ gene
Journal of Veterinary Internal Medicine, 32(2), 665–669.
author keywords: deafness; Doberman Pinscher; genetics; PTPRQ; vestibular disease
MeSH headings : Animals; Dog Diseases / genetics; Dogs; Female; Frameshift Mutation; Hearing Loss / genetics; Hearing Loss / veterinary; Receptor-Like Protein Tyrosine Phosphatases, Class 3 / genetics; Vestibular Diseases / genetics; Vestibular Diseases / veterinary; Whole Genome Sequencing
TL;DR:
The identification of a genetic alteration on the PTPRQ gene that is associated with congenital hearing and vestibular disorder in a young Doberman Pinscher dog is reported.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, NC State University Libraries, Crossref, ORCID
Added: August 6, 2018
2018 journal article
Development of an International Canine Spinal Cord Injury observational registry: a collaborative data-sharing network to optimize translational studies of SCI
Spinal Cord, 56(7), 656–665.
MeSH headings : Animals; Cohort Studies; Cross-Over Studies; Disease Models, Animal; Dogs; Europe; Female; Information Dissemination; International Cooperation; Male; Registries; Spinal Cord Injuries / epidemiology; Spinal Cord Injuries / therapy; Spinal Cord Injuries / veterinary; Translational Research, Biomedical / methods; United States
TL;DR:
Analysis of data accumulated during the first year of the canine SCI registry suggests that 16% of dogs with SCI present with severe, sensorimotor-complete injury and that 15% of cases are seen by a tertiary care facility within 8 h of injury.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, NC State University Libraries, Crossref
Added: August 6, 2018
2018 conference paper
Investigation of Sensory Thresholds in Cavalier King Charles Spaniels with and without Chiari-like Malformations and Syringomyelia
Pain in Animals Workshop 2017: Abstracts. Presented at the Pain in Animals Workshop 2017: Abstracts.
Event: Pain in Animals Workshop 2017: Abstracts
Sources: Crossref, NC State University Libraries
Added: January 25, 2020
2018 journal article
Investigation of sensory thresholds in Cavalier King Charles Spaniels with and without Chiari-like malformations and syringomyelia
Journal of Veterinary Internal Medicine, 32(6), 2021–2028.
author keywords: neuropathic pain; paresthesia; phantom scratch; syrinx
MeSH headings : Animals; Brain / diagnostic imaging; Brain / physiopathology; Budd-Chiari Syndrome / diagnostic imaging; Budd-Chiari Syndrome / physiopathology; Budd-Chiari Syndrome / veterinary; Case-Control Studies; Dog Diseases / diagnostic imaging; Dog Diseases / physiopathology; Dogs; Female; Hypesthesia / physiopathology; Hypesthesia / veterinary; Magnetic Resonance Imaging / veterinary; Male; Neuroimaging / veterinary; Sensory Thresholds / physiology; Syringomyelia / diagnostic imaging; Syringomyelia / physiopathology; Syringomyelia / veterinary
TL;DR:
Mechanical and thermal sensitivity does not appear to be related to the presence of SM, but mechanical sensitivity appears to berelated to the existence of pain and clinical signs.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
Sources: Web Of Science, NC State University Libraries, Crossref, ORCID
Added: December 31, 2018
2018 journal article
Predictors of Response to 4-Aminopyridine in Chronic Canine Spinal Cord Injury
Journal of Neurotrauma, 36(9), 1428–1434.
author keywords: canine; chronic SCI; motor neuron pool excitability; potassium channel antagonist; spasticity
MeSH headings : 4-Aminopyridine / pharmacology; Animals; Dogs; Evoked Potentials, Motor / physiology; Female; H-Reflex / physiology; Male; Motor Neurons / physiology; Muscle Spasticity / physiopathology; Potassium Channel Blockers / pharmacology; Spinal Cord Injuries / physiopathology
TL;DR:
Comparing clinical, electrodiagnostic, gait, and imaging variables between dogs that do and do not respond to 4AP, to identify predictors of response suggested Severity of spasticity and H-reflex threshold might allow prediction of response.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
Sources: Web Of Science, Crossref, NC State University Libraries
Added: December 31, 2018
2018 journal article
Saccadic oscillations in 4 dogs and 1 cat
Journal of Veterinary Internal Medicine, 32(4), 1392–1396.
author keywords: cerebellum; macrosaccadic oscillations; opsoclonus; vestibular disease
MeSH headings : Animals; Cat Diseases / diagnosis; Cat Diseases / physiopathology; Cats; Dog Diseases / diagnosis; Dog Diseases / physiopathology; Dogs; Eye Movement Measurements / veterinary; Female; Male; Neurologic Examination / veterinary; Ocular Motility Disorders / diagnosis; Ocular Motility Disorders / physiopathology; Ocular Motility Disorders / veterinary
TL;DR:
The clinical histories of three dogs and one cat displaying involuntary eye movements consistent with opsoclonus are presented, with final diagnoses including idiopathic generalized tremor syndrome and neuronal ceroid lipofuscinosis (NCL).
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
Sources: Crossref, NC State University Libraries, ORCID
Added: September 19, 2020
2018 journal article
The Effect of Electromagnetic Fields on Post-Operative Pain and Locomotor Recovery in Dogs with Acute, Severe Thoracolumbar Intervertebral Disc Extrusion: A Randomized Placebo-Controlled, Prospective Clinical Trial
Journal of Neurotrauma, 35(15), 1726–1736.
Contributors: N. Zidan n, J. Fenn *, E. Griffith n, P. Early n, C. Mariani n , K. Muñana n , J. Guevar n, n
author keywords: biomarker; GFAP; hemilaminectomy; pain; spinal cord injury
MeSH headings : Animals; Decompression, Surgical; Dog Diseases / therapy; Dogs; Female; Intervertebral Disc Displacement / complications; Intervertebral Disc Displacement / surgery; Lumbar Vertebrae; Magnetic Field Therapy / methods; Male; Pain, Postoperative / etiology; Pain, Postoperative / therapy; Random Allocation; Recovery of Function / radiation effects; Spinal Cord Injuries / etiology; Spinal Cord Injuries / therapy; Thoracic Vertebrae
TL;DR:
It is concluded that PEMF reduced incision-associated pain in dogs post-surgery for IVDE and may reduce extent of SCI and enhance proprioceptive placing.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
Sources: Web Of Science, Crossref, NC State University Libraries, ORCID
Added: August 6, 2018
2017 journal article
Associations Between Anesthetic Variables and Functional Outcome in Dogs With Thoracolumbar Intervertebral Disk Extrusion Undergoing Decompressive Hemilaminectomy
Journal of Veterinary Internal Medicine, 31(3), 814–824.
Contributors: J. Fenn *, E. Laber n, K. Williams n, C. Rousse n, P. Early n, C. Mariani n , K. Muñana n , S. De Decker *, H. Volk *, n
author keywords: Anesthesia; Canine; Intervertebral disk extrusion; Prognosis; Spinal cord injury
MeSH headings : Anesthesia, General / adverse effects; Anesthesia, General / methods; Anesthesia, General / veterinary; Animals; Bradycardia / chemically induced; Bradycardia / veterinary; Decompression, Surgical / methods; Decompression, Surgical / veterinary; Dog Diseases / surgery; Dogs; Female; Hypotension / chemically induced; Hypotension / veterinary; Intervertebral Disc Displacement / surgery; Intervertebral Disc Displacement / veterinary; Laminectomy / methods; Laminectomy / veterinary; Male; Retrospective Studies; Thoracic Vertebrae / surgery; Treatment Outcome
TL;DR:
Across all outcome measures, regression tree analysis highlighted functional grade at presentation as the primary determining factor, and among pain perception negative dogs, there was a possible association between increased duration of surgery and poorer outcome.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
1. No Poverty
(OpenAlex)
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, Crossref, NC State University Libraries, ORCID
Added: August 6, 2018
2017 journal article
Clinical Characteristics of Dogs with Progressive Myelomalacia Following Acute Intervertebral Disc Extrusion
Journal of Veterinary Internal Medicine, 31(6), 1782–1789.
Contributors: A. Castel n, n , C. Mariani n , K. Muñana n & P. Early n
author keywords: Ascending-descending myelomalacia; Intervertebral disc disease; Spinal cord injury
MeSH headings : Animals; Disease Progression; Dog Diseases / diagnostic imaging; Dog Diseases / pathology; Dogs; Female; Intervertebral Disc Degeneration / diagnostic imaging; Intervertebral Disc Degeneration / pathology; Intervertebral Disc Degeneration / veterinary; Intervertebral Disc Displacement / diagnostic imaging; Intervertebral Disc Displacement / pathology; Intervertebral Disc Displacement / veterinary; Magnetic Resonance Imaging / veterinary; Male; Myelography / veterinary; Retrospective Studies; Spinal Cord Diseases / mortality; Spinal Cord Diseases / pathology; Spinal Cord Diseases / veterinary; Tomography, X-Ray Computed / veterinary
TL;DR:
The majority of dogs developed PMM within 2 days of presentation and was euthanized within another 3 days, however, onset can be delayed up to 5 days after presentation with progression to euthanasia taking as long as 2 weeks.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
Sources: Web Of Science, Crossref, NC State University Libraries, ORCID
Added: August 6, 2018
2017 journal article
Development of a clinical spasticity scale for evaluation of dogs with chronic thoracolumbar spinal cord injury
American Journal of Veterinary Research, 78(7), 854–861.
MeSH headings : Adult; Animals; Dogs / injuries; Gait; Hindlimb; Humans; Muscle Spasticity / diagnosis; Muscle Spasticity / physiopathology; Muscle Spasticity / veterinary; Paralysis / etiology; Paralysis / veterinary; Prospective Studies; Reproducibility of Results; Spinal Cord Injuries / diagnosis; Spinal Cord Injuries / physiopathology; Spinal Cord Injuries / veterinary
TL;DR:
The CSS could be used to quantify hind limb spasticity in dogs with chronic thoracolumbar SCI and might be a useful outcome measure and Flexor spasms may represent an integral part of stepping in Dogs with severe SCI.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
Sources: Crossref, NC State University Libraries
Added: July 27, 2019
2017 journal article
Evaluation of gene expression and DNA copy number profiles of adipose tissue-derived stromal cells and consecutive neurosphere-like cells generated from dogs with naturally occurring spinal cord injury
American Journal of Veterinary Research, 78(3), 371–380.
MeSH headings : Adipose Tissue / cytology; Animals; Cells, Cultured; Comparative Genomic Hybridization; Dogs; Female; Gene Dosage / genetics; Gene Expression Profiling; Gene Expression Regulation; Male; Neural Stem Cells / cytology; Neural Stem Cells / pathology; Neurons / cytology; Neurons / pathology; Proteins / genetics; Spinal Cord Injuries / physiopathology; Spinal Cord Injuries / veterinary; Stromal Cells / cytology; Stromal Cells / physiology
TL;DR:
ADSCs can potentially be a safe and clinically relevant autologous source for canine neural progenitor cells and DNA copy number stability was suggested by the methods used.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(OpenAlex)
Sources: NC State University Libraries, Crossref, NC State University Libraries, ORCID
Added: August 6, 2018
2017 journal article
Genetics of Hereditary Ataxia in Scottish Terriers
Journal of Veterinary Internal Medicine, 31(4), 1132–1139.
author keywords: Canine; Cerebellar abiotrophy; Cerebellar ataxia; Neurodegeneration
MeSH headings : Animals; Brain / diagnostic imaging; Dog Diseases / diagnostic imaging; Dog Diseases / genetics; Dogs; Female; Genetic Linkage / genetics; Genome-Wide Association Study / veterinary; Homozygote; Magnetic Resonance Imaging / veterinary; Male; Neuroimaging / veterinary; Pedigree; Spinocerebellar Degenerations / diagnostic imaging; Spinocerebellar Degenerations / genetics; Spinocerebellar Degenerations / veterinary
TL;DR:
This finding suggests that further genetic investigation of the potential region of interest on CFA X should be considered in order to identify the causal mutation as well as develop a genetic test to eliminate the disease from this breed.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, Crossref, NC State University Libraries
Added: August 6, 2018
2017 journal article
Magnetic resonance imaging features of dogs with incomplete recovery after acute, severe spinal cord injury
Spinal Cord, 56(2), 133–141.
MeSH headings : Analysis of Variance; Animals; Dogs; Female; Image Processing, Computer-Assisted; Magnetic Resonance Imaging; Male; Recovery of Function / physiology; Spinal Cord / diagnostic imaging; Spinal Cord Injuries / diagnostic imaging; Spinal Cord Injuries / physiopathology; Spinal Cord Injuries / veterinary
TL;DR:
Findings demonstrate a spectrum of injury severity on MRI among severely affected dogs, which is related to functional status.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
Sources: Web Of Science, ORCID, Crossref, NC State University Libraries
Added: August 6, 2018
2017 journal article
Quantifying center of pressure variability in chondrodystrophoid dogs
The Veterinary Journal, 226, 26–31.
author keywords: Locomotion; Kinematics; Center of gravity
MeSH headings : Animals; Biomechanical Phenomena; Cartilage / growth & development; Dog Diseases / physiopathology; Dogs / anatomy & histology; Dogs / physiology; Gait; Species Specificity; Spinal Cord Injuries / physiopathology; Spinal Cord Injuries / veterinary
TL;DR:
In conclusion, COP variability can be measured consistently in dogs, and a range of COP variability for normal chondrodystrophoid dogs has been determined to provide a baseline for future studies on dogs with spinal cord injury.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
Sources: Web Of Science, Crossref, NC State University Libraries
Added: August 6, 2018
2017 journal article
Questionnaire-based Analysis of Owner-reported Scratching and Pain Signs in Cavalier King Charles Spaniels Screened for Chiari-like Malformation and Syringomyelia
Journal of Veterinary Internal Medicine, 32(1), 331–339.
author keywords: Neuropathic pain; Paresthesia; Phantom scratch; Syrinx
MeSH headings : Animals; Arnold-Chiari Malformation / diagnostic imaging; Arnold-Chiari Malformation / pathology; Arnold-Chiari Malformation / veterinary; Dog Diseases / diagnosis; Dog Diseases / diagnostic imaging; Dog Diseases / pathology; Dogs; Female; Magnetic Resonance Imaging / veterinary; Male; Neuroimaging / veterinary; Pain / pathology; Pain / veterinary; Pruritus / pathology; Pruritus / veterinary; Surveys and Questionnaires; Syringomyelia / diagnostic imaging; Syringomyelia / pathology; Syringomyelia / veterinary
TL;DR:
Lack of association of owner‐reported signs with SM highlights the lack of understanding of the pathophysiology of pain in this disease.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, ORCID, Crossref, NC State University Libraries
Added: August 6, 2018
2017 journal article
Targeting Translational Successes through CANSORT-SCI: Using Pet Dogs To Identify Effective Treatments for Spinal Cord Injury
Journal of Neurotrauma, 34(12), 2007–2018.
author keywords: animal model; clinical trial; dog; spinal cord injury
MeSH headings : Animals; Disease Models, Animal; Dogs; Pets; Spinal Cord Injuries; Translational Research, Biomedical
TL;DR:
The high prevalence of acute, naturally occurring SCI in pet dogs provides a unique opportunity to evaluate expeditiously promising interventions in a population of animals that receive diagnoses and treatment clinically in a manner similar to persons with SCI, while adhering to National Institutes of Health guidelines for scientific rigor and transparent reporting.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, Crossref, NC State University Libraries
Added: August 6, 2018
2017 journal article
The Frequency and Clinical Implications of Bacteriuria in Chronically Paralyzed Dogs
Journal of Veterinary Internal Medicine, 31(6), 1790–1795.
author keywords: Canine; Incontinence; Spinal cord injury; Urinary tract infection
MeSH headings : Animals; Bacteriuria / complications; Bacteriuria / mortality; Bacteriuria / veterinary; Dog Diseases / pathology; Dogs; Female; Fever / veterinary; Male; Paraplegia / complications; Paraplegia / veterinary; Pyuria / veterinary; Retrospective Studies; Urinary Tract Infections / complications; Urinary Tract Infections / diagnosis; Urinary Tract Infections / veterinary
TL;DR:
Bacteriuria is common in paralyzed dogs but does not cause fever; diagnostic criteria of UTI are unclear, and an association of bacteriuria with survival, but this needs further confirmation.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
Sources: Web Of Science, Crossref, NC State University Libraries, ORCID
Added: August 6, 2018
2017 journal article
The Relationship between Lesion Severity Characterized by Diffusion Tensor Imaging and Motor Function in Chronic Canine Spinal Cord Injury
Journal of Neurotrauma, 35(3), 500–507.
author keywords: chronic paralysis; fractional anisotropy; magnetic resonance imaging; mean diffusivity; tractography
MeSH headings : Animals; Diffusion Tensor Imaging; Dogs; Image Processing, Computer-Assisted; Motor Activity / physiology; Spinal Cord Injuries / veterinary
TL;DR:
Findings suggest DTI quantifies injury severity and suggests motor recovery in apparently complete dogs is because of supraspinal input.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
Sources: Crossref, NC State University Libraries
Added: July 27, 2019
2017 journal article
The Relationship between Trans-Lesional Conduction, Motor Neuron Pool Excitability, and Motor Function in Dogs with Incomplete Recovery from Severe Spinal Cord Injury
Journal of Neurotrauma, 34(21), 2994–3002.
author keywords: central pattern generator; disc extrusion; electrophysiology; motor evoked potentials
MeSH headings : Animals; Dogs; Evoked Potentials, Motor / physiology; Evoked Potentials, Somatosensory / physiology; Gait / physiology; H-Reflex / physiology; Locomotion / physiology; Motor Neurons / physiology; Recovery of Function / physiology; Spinal Cord Injuries / physiopathology; Transcranial Magnetic Stimulation
TL;DR:
The association between pelvic limb MEPs and gait scores supports the importance of descending influence on regaining walking after severe TL-SCI in dogs rather than just activation of spinal walking and implies that increases in motor neuron pool excitability might also contribute to motor recovery.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
Sources: Web Of Science, Crossref, NC State University Libraries
Added: August 6, 2018
2016 journal article
Acute change in neurological level following canine intervertebral disc herniation
Journal of Small Animal Practice, 57(4), 220–220.
MeSH headings : Animals; Diagnosis, Differential; Dog Diseases / diagnostic imaging; Dog Diseases / etiology; Dog Diseases / surgery; Dogs; Intervertebral Disc Displacement / complications; Intervertebral Disc Displacement / diagnostic imaging; Intervertebral Disc Displacement / surgery; Intervertebral Disc Displacement / veterinary; Magnetic Resonance Imaging / veterinary; Male; Nervous System Diseases / etiology; Nervous System Diseases / veterinary; Paraplegia / etiology; Paraplegia / veterinary; Postoperative Complications / veterinary; Reflex
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, Crossref, NC State University Libraries
Added: August 6, 2018
2016 journal article
Clinical and Diagnostic Imaging Features of Brain Herniation in Dogs and Cats
Journal of Veterinary Internal Medicine, 30(5), 1672–1680.
MeSH headings : Animals; Body Size; Brain / diagnostic imaging; Brain / pathology; Cat Diseases / diagnostic imaging; Cat Diseases / pathology; Cats; Dog Diseases / diagnostic imaging; Dog Diseases / pathology; Dogs; Magnetic Resonance Imaging / veterinary; Retrospective Studies
TL;DR:
Brain herniation can be quantified on MRI and more severe CTH based on TTX is associated with a worse short‐term outcome, compared with more severe foramen magnum based on FMH.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: NC State University Libraries, Crossref, NC State University Libraries, ORCID
Added: August 6, 2018
2016 review
Clinical characteristics of canine fibrocartilaginous embolic myelopathy (FCE): a systematic review of 393 cases (1973-2013)
[Review of ]. Veterinary Record, 179(25), 650-.
Source: NC State University Libraries
Added: August 6, 2018
2016 journal article
Clinical characteristics of canine fibrocartilaginous embolic myelopathy (FCE): a systematic review of 393 cases (1973–2013)
Veterinary Record, 179(25), 650–650.
MeSH headings : Animals; Cartilage Diseases / diagnosis; Cartilage Diseases / veterinary; Dog Diseases / diagnosis; Dogs; Embolism / diagnosis; Embolism / veterinary; Spinal Cord Diseases / diagnosis; Spinal Cord Diseases / veterinary
TL;DR:
Prognosis for recovery of ambulation was good to excellent with 85 per cent of cases regaining the ability to walk unassisted, most within 3 weeks, and future prospective studies should evaluate prognosis for more severely affected patients.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Source: Crossref
Added: July 27, 2019
2016 journal article
Effect of Cranberry Extract on the Frequency of Bacteriuria in Dogs with Acute Thoracolumbar Disk Herniation: A Randomized Controlled Clinical Trial
Journal of Veterinary Internal Medicine, 31(1), 60–68.
Contributors: n , S. Vaden n, K. Williams n, E. Griffith n, T. Harris n, C. Mariani n , K. Muñana n , P. Early n
author keywords: Escherichia coli; Incontinence; Proanthocyanidins; Spinal cord injury
MeSH headings : Administration, Oral; Animals; Anti-Infective Agents / administration & dosage; Anti-Infective Agents / therapeutic use; Bacteriuria / complications; Bacteriuria / drug therapy; Bacteriuria / urine; Bacteriuria / veterinary; Dog Diseases / drug therapy; Dogs; Female; Intervertebral Disc Displacement / complications; Intervertebral Disc Displacement / veterinary; Male; Plant Extracts / administration & dosage; Plant Extracts / therapeutic use; Prospective Studies; Single-Blind Method; Thoracic Vertebrae; Treatment Outcome; Urinary Tract Infections / complications; Urinary Tract Infections / drug therapy; Urinary Tract Infections / urine; Urinary Tract Infections / veterinary; Vaccinium macrocarpon
TL;DR:
This clinical trial did not show a benefit of oral cranberry extract but had low power, but a possible association between urine AAA and lower risk of E. coli bacteriuria was identified.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, Crossref, NC State University Libraries, ORCID
Added: August 6, 2018
2016 journal article
Generation of pure cultures of autologous Schwann cells by use of biopsy specimens of the dorsal cutaneous branches of the cervical nerves of young adult dogs
American Journal of Veterinary Research, 77(10), 1166–1174.
MeSH headings : Animals; Biopsy / veterinary; Cadaver; Cell Culture Techniques / veterinary; Cells, Cultured / cytology; Cervical Plexus / cytology; Dogs; Female; Male; Nerve Regeneration; Schwann Cells / cytology
TL;DR:
SCs could be cultured from biopsy specimens of dorsal cervical cutaneous nerves and purified and expanded to generate adequate numbers for autologous transplants to treat dogs with spinal cord and peripheral nerve injuries.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, Crossref, NC State University Libraries
Added: August 6, 2018
2016 journal article
Longitudinal Study of the Relationship among Craniocervical Morphology, Clinical Progression, and Syringomyelia in a Cohort of Cavalier King Charles Spaniels
Journal of Veterinary Internal Medicine, 30(4), 1090–1098.
author keywords: Atlantoaxial band; Chiari-like malformation; Dysesthesia; Neuropathic pain
MeSH headings : Animals; Atlanto-Axial Joint / diagnostic imaging; Atlanto-Axial Joint / pathology; Cohort Studies; Dog Diseases / diagnostic imaging; Dog Diseases / pathology; Dogs; Female; Humans; Longitudinal Studies; Magnetic Resonance Imaging / veterinary; Male; Pedigree; Severity of Illness Index; Surveys and Questionnaires; Syringomyelia / diagnostic imaging; Syringomyelia / pathology; Syringomyelia / veterinary
TL;DR:
The morphology of the CCJ at initial imaging did not predict development of either new or worsened signs or syringomyelia by the time of re‐evaluation, and Craniocervical junction anomalies assessed in this study did not appear predictive of future clinical status or syringsomyelia in this cohort.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
Sources: Web Of Science, Crossref, NC State University Libraries
Added: August 6, 2018
2016 journal article
Mechanical and Thermal Sensory Testing in Normal Chondrodystrophoid Dogs and Dogs with Spinal Cord Injury caused by Thoracolumbar Intervertebral Disc Herniations
Journal of Veterinary Internal Medicine, 30(2), 627–635.
Contributors: A. Gorney n, S. Blau n, C. Dohse n, E. Griffith n, K. Williams n, J. Lim n, D. Knazovicky n , B. Lascelles n, n
author keywords: Allodynia; Mechanical threshold; Nociception; Quantitative sensory testing; Thermal threshold
MeSH headings : Animals; Cold Temperature; Dog Diseases / diagnosis; Dogs; Female; Hot Temperature; Intervertebral Disc Displacement / diagnosis; Intervertebral Disc Displacement / veterinary; Male; Pressure; Sensory Thresholds / physiology; Spinal Cord Injuries / diagnosis; Spinal Cord Injuries / veterinary
TL;DR:
The differences in sensation among neurologic grades indicate that these techniques can be used to further characterize recovery of SCI dogs and can be measured reliably in chondrodystrophoid dogs and are altered by SCI.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
Sources: Web Of Science, NC State University Libraries, ORCID, Crossref
Added: August 6, 2018
2016 journal article
Recovery of stepping and coordination in dogs following acute thoracolumbar intervertebral disc herniations
The Veterinary Journal, 213, 59–63.
Contributors: C. Rousse n, n , K. Williams n, T. Harris n, E. Griffith n, C. Mariani n , K. Muñana n , P. Early n
author keywords: Canine; Gait; Locomotion; Paralysis; Spinal cord injury
MeSH headings : Acute Disease; Animals; Dog Diseases / etiology; Dog Diseases / surgery; Dogs; Female; Forelimb / physiology; Hindlimb / physiology; Intervertebral Disc / pathology; Intervertebral Disc / surgery; Intervertebral Disc Displacement / etiology; Intervertebral Disc Displacement / surgery; Intervertebral Disc Displacement / veterinary; Male; Prospective Studies; Spinal Cord Injuries / etiology; Spinal Cord Injuries / surgery; Spinal Cord Injuries / veterinary; Walking
TL;DR:
Recovery of coordination was incomplete in dogs that showed good recovery of stepping in the 6 weeks following surgical decompression of dogs with TL-IVDH.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
Sources: Web Of Science, Crossref, NC State University Libraries, ORCID
Added: August 6, 2018
2016 journal article
Use of posaconazole for treatment of disseminated protothecosis in a dog
Veterinary Record Case Reports, 4(2), e000350.
TL;DR:
The clinical improvement produced by posaconazole in this case suggests it may be an effective therapy for this typically fatal disease, but it may currently be cost prohibitive.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(OpenAlex)
Sources: Crossref, NC State University Libraries, ORCID
Added: September 13, 2020
2015 journal article
A Placebo-Controlled, Prospective, Randomized Clinical Trial of Polyethylene Glycol and Methylprednisolone Sodium Succinate in Dogs with Intervertebral Disk Herniation
JOURNAL OF VETERINARY INTERNAL MEDICINE, 30(1), 206–214.
Contributors: n , A. Muguet-Chanoit n, J. Lim n, M. Davidian n , C. Mariani n , A. Freeman*, S. Platt *, J. Humphrey n
author keywords: Neuroprotection; Paraplegia; Secondary injury; Spinal cord injury
MeSH headings : Animals; Anti-Inflammatory Agents / administration & dosage; Anti-Inflammatory Agents / therapeutic use; Dog Diseases / drug therapy; Dogs; Female; Intervertebral Disc Displacement / drug therapy; Intervertebral Disc Displacement / veterinary; Male; Methylprednisolone Hemisuccinate / administration & dosage; Methylprednisolone Hemisuccinate / therapeutic use; Nociception / drug effects; Polyethylene Glycols / administration & dosage; Polyethylene Glycols / therapeutic use
TL;DR:
This clinical trial did not show a benefit of either MPSS or PEG in the treatment of acute, severe thoracolumbar IVDH when used as adjunctive medical treatment administered to dogs presenting within 24 hours of onset of paralysis.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
Sources: Web Of Science, NC State University Libraries, ORCID
Added: August 6, 2018
2015 journal article
Clinical characteristics of Scottie Cramp in 31 cases
Journal of Small Animal Practice, 56(4), 276–280.
MeSH headings : Animals; Breeding; Cerebellum / pathology; Dog Diseases / drug therapy; Dog Diseases / genetics; Dog Diseases / physiopathology; Dogs; Female; Fluoxetine / therapeutic use; Genetic Predisposition to Disease; Male; Muscle Cramp / drug therapy; Muscle Cramp / genetics; Muscle Cramp / physiopathology; Muscle Cramp / veterinary; Muscle Hypertonia / drug therapy; Muscle Hypertonia / genetics; Muscle Hypertonia / physiopathology; Muscle Hypertonia / veterinary; Selective Serotonin Reuptake Inhibitors / therapeutic use; Severity of Illness Index; Sex Factors; Spinocerebellar Degenerations / genetics; Spinocerebellar Degenerations / physiopathology; Spinocerebellar Degenerations / veterinary
TL;DR:
The disorder recognised as Scottie Cramp by dog owners includes dogs with hind limb spasticity in addition to generalised cramping, which usually improve over time without specific treatment.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
Sources: Web Of Science, Crossref, NC State University Libraries
Added: August 6, 2018
2015 journal article
Dorsal Compressive Atlantoaxial Bands and the Craniocervical Junction Syndrome: Association with Clinical Signs and Syringomyelia in Mature Cavalier King Charles Spaniels
Journal of Veterinary Internal Medicine, 29(3), 887–892.
author keywords: Chiari-like; Compression index; Fibrous band; Magnetic resonance imaging
MeSH headings : Animals; Atlanto-Axial Joint / pathology; Dog Diseases / pathology; Dogs; Female; Magnetic Resonance Imaging / veterinary; Male; Spinal Cord Compression / diagnosis; Spinal Cord Compression / pathology; Spinal Cord Compression / veterinary; Syndrome; Syringomyelia / diagnosis; Syringomyelia / pathology; Syringomyelia / veterinary
TL;DR:
Positioning of dogs in extension during MRI enhances the sensitivity of the study for detecting this important abnormality, and there were significant associations among AA bands, clinical signs, and SM in dogs with CM.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
Sources: Web Of Science, Crossref, NC State University Libraries
Added: August 6, 2018
2015 journal article
Evaluation of a DLA-79 allele associated with multiple immune-mediated diseases in dogs
Immunogenetics, 68(3), 205–217.
Contributors: S. Friedenberg n, G. Buhrman n, L. Chdid n, n , T. Olivry n , J. Guillaumin *, T. O’Toole*, R. Goggs *
author keywords: Canine; Immune-mediated disease; Dog leukocyte antigen; Major histocompatibility complex class Ib
MeSH headings : Alleles; Amino Acid Substitution; Animals; Autoimmune Diseases / genetics; Autoimmune Diseases / immunology; Binding Sites; Dog Diseases / genetics; Dog Diseases / immunology; Dogs; Exons; Gene Frequency; Genetic Predisposition to Disease; Genotype; Histocompatibility Antigens Class I / chemistry; Histocompatibility Antigens Class I / genetics; Histocompatibility Antigens Class I / immunology; Immune System Diseases / veterinary; Meta-Analysis as Topic; Models, Molecular; Peptides / chemistry; Peptides / metabolism; Phenotype; Polymorphism, Single Nucleotide; Protein Conformation; Reproducibility of Results; Structure-Activity Relationship
TL;DR:
A strong association is demonstrated between two polymorphic positions (10 bp apart) in exon 2 of one allele in D LA-79, DLA-79*001:02, and multiple immune-mediated diseases, resulting in F33L and N37D amino acid changes that are likely to affect critical interactions with the peptide N-terminus.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, Crossref, NC State University Libraries, ORCID
Added: August 6, 2018
2015 journal article
Histiocytic Sarcoma with Central Nervous System Involvement in Dogs: 19 Cases (2006-2012)
Journal of Veterinary Internal Medicine, 29(2), 607–613.
author keywords: Brain tumor; Malignant histiocytosis; Round cell tumor; Spinal cord tumor
MeSH headings : Animals; Central Nervous System Neoplasms / pathology; Central Nervous System Neoplasms / veterinary; Dog Diseases / pathology; Dogs; Female; Histiocytic Sarcoma / pathology; Histiocytic Sarcoma / veterinary; Male; Retrospective Studies
TL;DR:
Some unique imaging and clinicopathologic characteristics, particularly brain herniation, profound meningeal enhancement, and pleocytosis in combination with 1 or more mass lesions, might help to differentiate this neoplasm from others involving the CNS, although this requires further study.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
Sources: Web Of Science, Crossref, NC State University Libraries, ORCID
Added: August 6, 2018
2015 journal article
Medullary Position at the Craniocervical Junction in Mature Cavalier King Charles Spaniels: Relationship with Neurologic Signs and Syringomyelia
Journal of Veterinary Internal Medicine, 29(3), 882–886.
author keywords: Cervicomedullary; Chiari-like; Medullary elevation; Medullary kinking
MeSH headings : Animals; Dog Diseases / pathology; Dogs; Female; Magnetic Resonance Imaging / veterinary; Male; Medulla Oblongata / pathology; Spinal Cord / pathology; Syringomyelia / pathology; Syringomyelia / veterinary
TL;DR:
There is a significant association between medullary elevation and clinical signs, whereas more caudal brainstem positions appear related to the presence of syringomyelia.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, Crossref, NC State University Libraries
Added: August 6, 2018
2015 journal article
The rationale for durotomy in surgical treatment of intervertebral disc disease
Advances in Intervertebral Disc Disease in Dogs and Cats, 251–254.
Source: NC State University Libraries
Added: August 6, 2018
2014 journal article
A rare homozygous MFSD8 single-base-pair deletion and frameshift in the whole genome sequence of a Chinese Crested dog with neuronal ceroid lipofuscinosis
BMC Veterinary Research, 10(1), 960.
author keywords: MFSD8; Neuronal ceroid lipofuscinosis; Chinese Crested; Whole genome sequence
MeSH headings : Animals; Cerebellum / pathology; Dog Diseases / genetics; Dog Diseases / pathology; Dogs / genetics; Frameshift Mutation / genetics; Gene Deletion; Genome / genetics; Homozygote; Magnetic Resonance Imaging / veterinary; Male; Membrane Transport Proteins / genetics; Neuroimaging / veterinary; Neuronal Ceroid-Lipofuscinoses / genetics; Neuronal Ceroid-Lipofuscinoses / veterinary
TL;DR:
The neurodegenerative disease of the Chinese Crested rescue dog was neuronal ceroid lipofuscinosis and that homozygosity for the MFSD8:c.843delT sequence variant was very likely to be the molecular-genetic cause of the disease.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
Sources: Crossref, NC State University Libraries, NC State University Libraries
Added: August 6, 2018
2014 journal article
Advances in Veterinary Neurology
Veterinary Clinics of North America: Small Animal Practice, 44(6), xi-xii.
MeSH headings : Animals; Central Nervous System Diseases / diagnosis; Central Nervous System Diseases / pathology; Central Nervous System Diseases / therapy; Central Nervous System Diseases / veterinary; Neurology / trends; Veterinary Medicine / trends
Sources: Crossref, NC State University Libraries
Added: July 27, 2019
2014 journal article
Advances in veterinary neurology preface
Veterinary Clinics of North America. Small Animal Practice, 44(6), XI-.
Source: NC State University Libraries
Added: August 6, 2018
2014 journal article
Canine Hereditary Ataxia
Veterinary Clinics of North America: Small Animal Practice, 44(6), 1075–1089.
author keywords: Cerebellar abiotrophy; Spinocerebellar; Purkinje neuron; Granuloprival degeneration
MeSH headings : Animals; Dog Diseases / classification; Dog Diseases / diagnosis; Dog Diseases / genetics; Dog Diseases / therapy; Dogs; Genetic Predisposition to Disease; Spinocerebellar Degenerations / classification; Spinocerebellar Degenerations / diagnosis; Spinocerebellar Degenerations / genetics; Spinocerebellar Degenerations / therapy; Spinocerebellar Degenerations / veterinary
TL;DR:
A breed-related neurodegenerative process should be suspected in any pure bred dog with slowly progressive, symmetric signs of ataxia.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
Sources: Crossref, NC State University Libraries, NC State University Libraries
Added: August 6, 2018
2014 journal article
Canine Hereditary Ataxia in Old English Sheepdogs and Gordon Setters Is Associated with a Defect in the Autophagy Gene Encoding RAB24
PLoS Genetics, 10(2), e1003991.
Ed(s): T. Leeb
MeSH headings : Animals; Autophagy / genetics; Cerebellar Cortex / pathology; Chromosome Mapping; Dog Diseases / genetics; Dog Diseases / pathology; Dogs; Genome-Wide Association Study; High-Throughput Nucleotide Sequencing; Humans; Mice; Mutation; Polymorphism, Single Nucleotide; Spinocerebellar Degenerations / etiology; Spinocerebellar Degenerations / genetics; rab GTP-Binding Proteins / genetics
TL;DR:
Histopathology, immunohistochemistry and ultrastructural evaluation of the brains of affected dogs from both breeds identified dramatic Purkinje neuron loss with axonal spheroids, accumulation of autophagosomes, ubiquitin positive inclusions and a diffuse increase in cytoplasmic neuronal ubiquit inclusions.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Crossref, NC State University Libraries, NC State University Libraries
Added: August 6, 2018
2014 journal article
Canine Paroxysmal Movement Disorders
Veterinary Clinics of North America: Small Animal Practice, 44(6), 1091–1102.
author keywords: Episodic movement disorders; Hypertonicity; Episodic falling; Hyperkinetic episode; Paroxysmal dyskinesia; Scottie cramp
MeSH headings : Animals; Chorea / diagnosis; Chorea / genetics; Chorea / pathology; Chorea / virology; Dog Diseases / diagnosis; Dog Diseases / genetics; Dog Diseases / pathology; Dogs; Genetic Predisposition to Disease
TL;DR:
A mutation in the gene for brevican (BCAN) has been identified as the cause of Episodic Falling in Cavalier King Charles spaniels and further elucidation of the genetic causes will enhance the ability to identify and treat these canine diseases.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
Sources: Crossref, NC State University Libraries, NC State University Libraries
Added: August 6, 2018
2014 journal article
Gait scoring in dogs with thoracolumbar spinal cord injuries when walking on a treadmill
BMC Veterinary Research, 10(1), 58.
author keywords: Coordination; Footstep sequence; Paresis; Paralysis; Regularity index; Intervertebral disc herniation; Spinal cord injury
MeSH headings : Animals; Biomechanical Phenomena; Dog Diseases / diagnosis; Dogs / injuries; Forelimb; Gait / physiology; Gait Disorders, Neurologic / diagnosis; Gait Disorders, Neurologic / veterinary; Hindlimb; Spinal Cord Injuries; Walking / physiology
TL;DR:
Dogs with naturally occurring spinal cord injury can walk on a treadmill without prior training and their hind limb function can be scored reliably using a stepping score and coordination score.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Crossref, NC State University Libraries, NC State University Libraries
Added: August 6, 2018
2014 journal article
Potassium Channel Antagonists 4-Aminopyridine and the T-Butyl Carbamate Derivative of 4-Aminopyridine Improve Hind Limb Function in Chronically Non-Ambulatory Dogs; A Blinded, Placebo-Controlled Trial
PLoS ONE, 9(12), e116139.
Ed(s): H. Sabaawy
MeSH headings : 4-Aminopyridine / adverse effects; 4-Aminopyridine / analogs & derivatives; 4-Aminopyridine / therapeutic use; Animals; Demyelinating Diseases / drug therapy; Dogs; Double-Blind Method; Female; Gait / drug effects; Hindlimb / physiopathology; Lameness, Animal / drug therapy; Male; Paralysis / drug therapy; Placebos / therapeutic use; Potassium Channel Blockers / therapeutic use; Spinal Cord Injuries / drug therapy; Treatment Outcome; Walking / physiology
TL;DR:
Both 4-AP and t- butyl significantly improved supported stepping ability in dogs with chronic spinal cord injury with no adverse effects noted with t-butyl.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
Sources: Crossref, NC State University Libraries, NC State University Libraries
Added: August 6, 2018
2013 journal article
Alternating Current Electric Fields of Varying Frequencies: Effects on Proliferation and Differentiation of Porcine Neural Progenitor Cells
Cellular Reprogramming, 15(5), 405–412.
MeSH headings : Animals; Cell Differentiation; Cell Proliferation; Cells, Cultured; Electricity; Electrodes; Fluorescence; Glial Fibrillary Acidic Protein / metabolism; Neural Stem Cells / cytology; Swine; Swine, Miniature; Tubulin / metabolism
TL;DR:
Higher frequency stimulation of low-frequency alternating current EFs via IDEs did not alter the alignment and proliferation of porcine neural progenitor cells, but higher frequency stimulation appeared to delay differentiation into mature astrocytes.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, Crossref, NC State University Libraries
Added: August 6, 2018
2013 journal article
Assessment of cord dorsum potentials from caudal nerves in anesthetized clinically normal adult dogs without or during neuromuscular blockade
American Journal of Veterinary Research, 74(4), 616–620.
MeSH headings : Action Potentials / drug effects; Action Potentials / physiology; Anesthesia / veterinary; Animals; Dogs; Female; Male; Nerve Net / drug effects; Nerve Net / physiology; Neuromuscular Blockade / veterinary; Spinal Cord / drug effects; Spinal Cord / physiology
TL;DR:
This technique may be useful as a tool to assess the caudal nerve roots in dogs suspected of having compressive lumbosacral disease or myelopathies affecting the lumbar intumescence.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, Crossref, NC State University Libraries, ORCID
Added: August 6, 2018
2013 journal article
Intervertebral Disk Degeneration in Dogs: Consequences, Diagnosis, Treatment, and Future Directions
Journal of Veterinary Internal Medicine, 27(6), 1318–1333.
author keywords: Compression; Computed tomography; Contusion; Magnetic resonance imaging; Prognosis; Spinal cord injury
MeSH headings : Animals; Clinical Trials as Topic / veterinary; Dog Diseases / diagnosis; Dog Diseases / pathology; Dog Diseases / surgery; Dogs; Intervertebral Disc Degeneration / diagnosis; Intervertebral Disc Degeneration / pathology; Intervertebral Disc Degeneration / surgery; Intervertebral Disc Degeneration / veterinary; Magnetic Resonance Imaging / veterinary; Spinal Cord Compression / diagnosis; Spinal Cord Compression / pathology; Spinal Cord Compression / surgery; Spinal Cord Compression / veterinary; Tomography, X-Ray Computed / veterinary
TL;DR:
This review summarizes the advances in diagnosis and treatment of IVDD that have been made since the 1950s and discusses new approaches to treatment of the associated spinal cord injury and new methods by which to classify injury severity that are currently under development.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
Sources: Web Of Science, Crossref, NC State University Libraries
Added: August 6, 2018
2013 journal article
Long-Term Effect of Cervical Distraction and Stabilization on Neurological Status and Imaging Findings in Giant Breed Dogs With Cervical Stenotic Myelopathy
Veterinary Surgery, 42(6), 701–709.
MeSH headings : Animals; Body Size; Cervical Vertebrae / pathology; Cervical Vertebrae / surgery; Dog Diseases / diagnostic imaging; Dog Diseases / pathology; Dog Diseases / surgery; Dogs; Female; Male; Retrospective Studies; Spinal Cord Compression / complications; Spinal Cord Compression / surgery; Spinal Cord Compression / veterinary; Spinal Stenosis / pathology; Spinal Stenosis / surgery; Spinal Stenosis / veterinary; Tomography, X-Ray Computed
TL;DR:
Distraction and stabilization with PMMA plugs and bone grafts is a safe surgical option for giant breed dogs with CSM with a single site of lateral or dorsolateral compression and long-term recurrence was common among dogs with multiple sites of compression.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
Sources: Web Of Science, Crossref, NC State University Libraries
Added: August 6, 2018
2012 journal article
Centronuclear Myopathy in Labrador Retrievers: A Recent Founder Mutation in the PTPLA Gene Has Rapidly Disseminated Worldwide
PLoS ONE, 7(10), e46408.
Ed(s): R. Veitia
MeSH headings : Alleles; Animals; Dog Diseases / genetics; Dogs; Founder Effect; Genes, Recessive; Mutation; Myopathies, Structural, Congenital / genetics; Myopathies, Structural, Congenital / veterinary; Phenotype; Protein Tyrosine Phosphatases / genetics
TL;DR:
Haplotype analysis demonstrated that the PTPLAcnm allele resulted from a single and recent mutational event that may have rapidly disseminated through the extensive use of popular sires, and will help define the integrated role of PTPLA in the existing CNM gene network.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Crossref, NC State University Libraries, NC State University Libraries
Added: August 6, 2018
2012 journal article
Evaluation of Levetiracetam as Adjunctive Treatment for Refractory Canine Epilepsy: A Randomized, Placebo-Controlled, Crossover Trial
JOURNAL OF VETERINARY INTERNAL MEDICINE, 26(2), 341–348.
Contributors: K. Muñana n , W. Thomas*, K. Inzana*, J. Nettifee-Osborne n, K. McLucas*, n , C. Mariani n , P. Early n
author keywords: Clinical pharmacology; CNS disorders; Dog; Epilepsy; Neurology; Seizures
MeSH headings : Animals; Anticonvulsants / administration & dosage; Anticonvulsants / adverse effects; Anticonvulsants / blood; Cross-Over Studies; Dog Diseases / blood; Dog Diseases / drug therapy; Dogs; Double-Blind Method; Epilepsy / blood; Epilepsy / drug therapy; Epilepsy / veterinary; Female; Levetiracetam; Male; Piracetam / administration & dosage; Piracetam / adverse effects; Piracetam / analogs & derivatives; Piracetam / blood; Quality of Life; Seizures / blood; Seizures / drug therapy; Seizures / veterinary; Statistics, Nonparametric
TL;DR:
Adjunctive treatment with LEV appears safe in epileptic dogs and effectiveness over placebo was not demonstrated, although the power of the study was limited.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
Sources: Web Of Science, NC State University Libraries, ORCID
Added: August 6, 2018
2012 journal article
GENERATION AND CHARACTERISATION OF INDUCED PLURIPOTENT STEM CELLS (iPSCs) FROM ADULT CANINE FIBROBLASTS
Reproduction, Fertility and Development, 24(1), 285.
TL;DR:
The isolated canine iPSCs have similar characteristics to ESCs from other species, but the exact cellular mechanisms behind their unique co-dependency on both FGF and LIF is still unknown.
(via Semantic Scholar)
Source: Crossref
Added: February 24, 2020
2012 conference paper
Generation and characterization of induced pluripotent stem cells (iPS) from adult canine fibroblasts
Reproduction in Domestic Animals, 47, 418–419.
Source: NC State University Libraries
Added: August 6, 2018
2012 journal article
Growth Requirements and Chromosomal Instability of Induced Pluripotent Stem Cells Generated from Adult Canine Fibroblasts
Stem Cells and Development, 22(6), 951–963.
Contributors: S. Koh n, R. Thomas n, S. Tsai n, S. Bischoff n, J. Lim n, M. Breen n , n , J. Piedrahita n
MeSH headings : Alkaline Phosphatase / metabolism; Animals; Antigens, Differentiation / genetics; Antigens, Differentiation / metabolism; Cell Differentiation; Cell Shape; Cells, Cultured; Chromosomal Instability; Coculture Techniques; Comparative Genomic Hybridization; Dogs; Fibroblasts / physiology; Gene Expression; In Situ Hybridization, Fluorescence; Induced Pluripotent Stem Cells / enzymology; Induced Pluripotent Stem Cells / pathology; Induced Pluripotent Stem Cells / transplantation; Kruppel-Like Factor 4; Mice; Mice, SCID; Recombinant Proteins / biosynthesis; Recombinant Proteins / genetics; Teratoma / genetics; Teratoma / pathology; Transcription Factors / biosynthesis; Transcription Factors / genetics
TL;DR:
The isolated ciPSCs have similar characteristics to ESCs from other species, but the exact cellular mechanisms behind their unique co-dependency on both FGF2 and LIF are still unknown.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, Crossref, NC State University Libraries, ORCID
Added: August 6, 2018
2012 journal article
Isolation and characterization of neural progenitor cells from adult canine brains
American Journal of Veterinary Research, 73(12), 1963–1968.
MeSH headings : Animals; Cell Culture Techniques / veterinary; Cell Differentiation; Cell Lineage; Dogs; Female; Hippocampus / cytology; Hippocampus / metabolism; Immunohistochemistry / veterinary; Lateral Ventricles / cytology; Lateral Ventricles / metabolism; Male; Neural Stem Cells / cytology; Neural Stem Cells / physiology; RNA / analysis; Reverse Transcriptase Polymerase Chain Reaction
TL;DR:
Results suggested the persistence of SOX2- Positive, nestin-positive, GFAP- positive,GFAP-Positive, OCT4-negative, and NANOG-negative neural progenitor cells in the SVZ and SGZ regions of mature canine brains, which are capable of producing multiple cell lineages.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, NC State University Libraries, Crossref, ORCID
Added: August 6, 2018
2011 journal article
Characterization of Immune Cell Infiltration Into Canine Intracranial Meningiomas
VETERINARY PATHOLOGY, 49(5), 784–795.
author keywords: brain; dog; immunohistochemistry; lymphocyte; meningioma; microglia; Toll-like receptor; tumor
MeSH headings : Animals; Antigens, CD / analysis; Antigens, CD / immunology; Biomarkers, Tumor / metabolism; Cytokines / metabolism; Dog Diseases / immunology; Dog Diseases / pathology; Dogs; Female; Forkhead Transcription Factors / metabolism; Immunohistochemistry / veterinary; Lymphocyte Subsets / immunology; Lymphocytes, Tumor-Infiltrating / immunology; Macrophages / immunology; Male; Meningeal Neoplasms / immunology; Meningeal Neoplasms / pathology; Meningeal Neoplasms / veterinary; Meningioma / immunology; Meningioma / pathology; Meningioma / veterinary; Paraffin Embedding / veterinary; Toll-Like Receptor 4 / metabolism; Toll-Like Receptor 9 / metabolism
TL;DR:
Investigation of the presence of a variety of immune cell subsets within canine intracranial meningiomas suggests that evaluation of this immune cell infiltrate may provide important prognostic information and may be useful in the design of novel therapies.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, NC State University Libraries, ORCID
Added: August 6, 2018
2011 journal article
Clinical progression of X-linked muscular dystrophy in two German Shorthaired Pointers
Journal of the American Veterinary Medical Association, 238(2), 207–212.
MeSH headings : Animals; Dog Diseases / genetics; Dog Diseases / pathology; Dogs; Male; Muscular Dystrophy, Animal / genetics; X Chromosome
TL;DR:
The clinical progression of muscular dystrophy in the 2 GSHPs was compared with that for other breeds and species with dystrophin-deficient conditions, and the potential basis for the phenotypic variation observed between these littermates, along with potential therapeutic ramifications for dogs and humans was evaluated.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
2. Zero Hunger
(OpenAlex)
3. Good Health and Well-being
(Web of Science)
Sources: Crossref, NC State University Libraries
Added: November 16, 2019
2011 journal article
Genome-wide linkage study of atopic dermatitis in West Highland White Terriers
BMC Genetics, 12(1), 37.
Contributors: C. Salzmann n, T. Olivry n, D. Nielsen n, J. Paps n, T. Harris n & n
MeSH headings : Animals; Chromosome Mapping; Dermatitis, Atopic / genetics; Dermatitis, Atopic / veterinary; Dog Diseases / genetics; Dogs; Genetic Linkage; Genotype
TL;DR:
The study was unable to detect any chromosomal regions significantly linked to canine AD, and a genome-wide SNP association study in a larger cohort of WHWTs may prove more successful by providing higher density coverage and higher statistical power.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Crossref, NC State University Libraries, ORCID, NC State University Libraries
Added: August 6, 2018
2011 journal article
Mapping of Purkinje Neuron Loss and Polyglucosan Body Accumulation in Hereditary Cerebellar Degeneration in Scottish Terriers
VETERINARY PATHOLOGY, 49(5), 852–859.
author keywords: dog; cerebellar abiotrophy; cerebellar ataxia; cerebellar cortex; inclusion; molecular layer; polyglucosan body
MeSH headings : Aging / pathology; Animals; Case-Control Studies; Cerebellar Cortex / metabolism; Cerebellar Cortex / pathology; Cerebellar Cortex / ultrastructure; Cerebellum / metabolism; Cerebellum / pathology; Cerebellum / ultrastructure; Dog Diseases / genetics; Dog Diseases / metabolism; Dog Diseases / pathology; Dogs; Female; Glucans / metabolism; Immunohistochemistry / veterinary; Inclusion Bodies / metabolism; Inclusion Bodies / pathology; Inclusion Bodies / ultrastructure; Male; Microscopy, Electron, Transmission / veterinary; Purkinje Cells / metabolism; Purkinje Cells / pathology; Purkinje Cells / ultrastructure; Spinocerebellar Degenerations / genetics; Spinocerebellar Degenerations / metabolism; Spinocerebellar Degenerations / pathology; Spinocerebellar Degenerations / veterinary
TL;DR:
Significant Purkinje cell loss and increased polyglucosan bodies in the cerebellum of affected Scottish Terriers are demonstrated.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018
2011 conference paper
Perspectives on transgenic livestock in agriculture and biomedicine: An update
Reproduction, Fertility and Development, 23(1), 56–63.
Source: NC State University Libraries
Added: August 6, 2018
2011 journal article
Perspectives on transgenic livestock in agriculture and biomedicine: an update
Reproduction, Fertility and Development, 23(1), 56.
author keywords: animal models; bioreactors; somatic cell nuclear transfer; spinal cord repair; xenotransplantation
MeSH headings : Agriculture / trends; Animals; Animals, Domestic; Animals, Genetically Modified; Biomedical Technology / trends; Nuclear Transfer Techniques / trends; Nuclear Transfer Techniques / veterinary; Pluripotent Stem Cells; Stem Cell Research
TL;DR:
The combination of advances in somatic cell nuclear transfer, the development of induced pluripotent stem cells and the completion of the sequencing of most livestock genomes ensures a bright and exciting future for this field, not only in livestock but also in companion animal species.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
2. Zero Hunger
(OpenAlex)
3. Good Health and Well-being
(Web of Science)
Source: Crossref
Added: February 24, 2020
2011 journal article
Possible Drug-Induced Hepatopathy in a Dog Receiving Zonisamide Monotherapy for Treatment of Cryptogenic Epilepsy
JOURNAL OF VETERINARY MEDICAL SCIENCE, 73(11), 1505–1508.
Contributors: M. Schwartz n, K. Muñana n & n
author keywords: antiepileptic drug; canine; idiosyncratic drug reaction; liver; seizure
MeSH headings : Animals; Anticonvulsants / adverse effects; Anticonvulsants / therapeutic use; Chemical and Drug Induced Liver Injury / diagnosis; Chemical and Drug Induced Liver Injury / veterinary; Dog Diseases / chemically induced; Dog Diseases / diagnosis; Dog Diseases / drug therapy; Dogs; Epilepsy / drug therapy; Epilepsy / veterinary; Female; Isoxazoles / adverse effects; Isoxazoles / therapeutic use; Zonisamide
TL;DR:
If signs of hepatotoxicity are recognised early and zonisamide is discontinued, complete recovery is possible and Veterinary practitioners and owners should be educated about the potential for an idiosyncratic drug reaction to Zonisamide.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
Sources: Web Of Science, NC State University Libraries, ORCID
Added: August 6, 2018
2011 journal article
TP53 Mutations in Canine Brain Tumors
VETERINARY PATHOLOGY, 49(5), 796–801.
author keywords: cancer genes; dog; gDNA; nervous system; oncology; polymerase chain reaction; sequencing
MeSH headings : Animals; Astrocytoma / genetics; Astrocytoma / veterinary; Brain Neoplasms / genetics; Brain Neoplasms / veterinary; DNA, Complementary / genetics; DNA, Neoplasm / chemistry; DNA, Neoplasm / genetics; Dog Diseases / genetics; Dogs; Exons / genetics; Female; Gene Frequency; Genes, p53 / genetics; Male; Mutation; RNA, Neoplasm / genetics; Sequence Analysis, DNA
TL;DR:
Genomic DNA from a series of 37 glial and 51 nonglial canine brain tumors was sequenced to determine the frequency of TP53 gene mutations involving exons 3–9, and exonic mutations were found in 3 of 88 tumors and specifically in 1 of 18 astrocytic tumors.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018
2011 journal article
The Cutaneous Trunci Muscle Reflex: A Predictor of Recovery in Dogs with Acute Thoracolumbar Myelopathies Caused by Intervertebral Disc Extrusions
Veterinary Surgery, 41(2), 200–206.
Contributors: A. Muguet-Chanoit n, n , J. Lim n, R. Gallagher, Z. Niman*, S. Dillard*, J. Campbell n, P. Early n
MeSH headings : Animals; Cohort Studies; Dog Diseases / physiopathology; Dogs; Female; Intervertebral Disc Degeneration / veterinary; Intervertebral Disc Displacement / veterinary; Male; Muscle, Skeletal / physiology; Muscular Diseases / physiopathology; Muscular Diseases / veterinary; Predictive Value of Tests; Reflex / physiology
TL;DR:
Postoperative changes of the caudal border of the CTM reflex are an early indicator of outcome in dogs with severe acute IVDE and cranial movement of theCTM reflex is significantly associated with improvement, but not associated with a long-term successful outcome.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, NC State University Libraries, Crossref, ORCID
Added: August 6, 2018
2011 journal article
The Sensory Field and Repeatability of the Cutaneous Trunci Muscle Reflex of the Dog
Veterinary Surgery, 40(7), 781–785.
MeSH headings : Animals; Dog Diseases / physiopathology; Dogs / physiology; Female; Lumbar Vertebrae; Male; Muscle, Skeletal / innervation; Muscle, Skeletal / physiology; Observer Variation; Prospective Studies; Reflex / physiology; Spinal Cord Diseases / physiopathology; Spinal Cord Diseases / veterinary; Thoracic Vertebrae
TL;DR:
The cutaneous trunci muscle (CTM) reflex is elicited caudal to L5 in most normal dogs, and the lateral sensory field extends to 50% or more of the circumference of the trunk.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Crossref, NC State University Libraries, NC State University Libraries
Added: August 6, 2018
2010 journal article
A canine Arylsulfatase G (ARSG) mutation leading to a sulfatase deficiency is associated with neuronal ceroid lipofuscinosis
Proceedings of the National Academy of Sciences, 107(33), 14775–14780.
author keywords: animal model; ataxia; dog; neurodegenerative; lysosome
MeSH headings : ATP-Binding Cassette Transporters / genetics; Age Factors; Animals; Arylsulfatases / deficiency; Arylsulfatases / genetics; Catalytic Domain / genetics; Cell Line; Cerebellar Cortex / metabolism; Cerebellar Cortex / pathology; Cerebellar Cortex / ultrastructure; Chromosome Mapping; Chromosomes, Mammalian / genetics; Dog Diseases / enzymology; Dog Diseases / genetics; Dogs; Female; Gene Expression Profiling; Gene Frequency; Genotype; Haplotypes; Humans; Male; Microscopy, Electron, Transmission; Molecular Sequence Data; Mutation, Missense; Neuronal Ceroid-Lipofuscinoses / veterinary; Pedigree; Polymorphism, Single Nucleotide; Reverse Transcriptase Polymerase Chain Reaction
TL;DR:
A protein involved in neuronal homeostasis is uncovered, a family of candidate genes to be screened in patients with Kufs' disease is identified, and it is suggested that a deficiency in sulfatase is part of the NCL pathogenesis.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Crossref, NC State University Libraries, NC State University Libraries
Added: August 6, 2018
2010 journal article
Development of a Model of Sacrocaudal Spinal Cord Injury in Cloned Yucatan MiniPigs for Cellular Transplantation Research
CELLULAR REPROGRAMMING, 12(6), 689–697.
MeSH headings : Animals; Behavior, Animal; Cauda Equina / pathology; Cauda Equina / surgery; Cell Culture Techniques; Cells, Cultured; Cloning, Organism; Green Fluorescent Proteins / metabolism; Humans; Models, Animal; Nerve Regeneration / physiology; Nuclear Transfer Techniques; Recovery of Function / physiology; Sacrum; Spinal Cord / pathology; Spinal Cord / surgery; Spinal Cord Injuries / pathology; Stem Cell Transplantation / methods; Swine; Swine, Miniature / surgery
TL;DR:
It is demonstrated that transection of the sacrocaudal spinal cord in Yucatan SCNT clones produces profound, quantifiable neurological deficits restricted to the tail, which represents a powerful research tool to investigate the effect of cellular transplantation on axonal regeneration and functional recovery.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018
2010 journal article
Development of a morphometric magnetic resonance image parameter suitable for distinguishing between normal dogs and dogs with cerebellar atrophy
Veterinary Radiology & Ultrasound, 51(3), 246–253.
Source: NC State University Libraries
Added: August 6, 2018
2010 journal article
Generation and Characterization of Neurospheres from Canine Adipose Tissue-Derived Stromal Cells
CELLULAR REPROGRAMMING, 12(4), 417–425.
MeSH headings : Adipose Tissue / metabolism; Animals; Biomarkers / metabolism; Blotting, Western; Bone and Bones / cytology; Bone and Bones / metabolism; Cell Differentiation; Cell Lineage; Cells, Cultured; Dogs; Flow Cytometry; Neurons / metabolism; Osteogenesis; Phenotype; RNA, Messenger / genetics; Reverse Transcriptase Polymerase Chain Reaction; Stem Cells / cytology; Stromal Cells / metabolism
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, NC State University Libraries, ORCID
Added: August 6, 2018
2010 journal article
Hereditary Cerebellar Degeneration in Scottish Terriers
JOURNAL OF VETERINARY INTERNAL MEDICINE, 24(3), 565–570.
author keywords: Canine; Cerebellar abiotrophy; Cerebellar ataxia; Polyglucosan body; Purkinje cell
MeSH headings : Animals; Cerebellum / pathology; Dog Diseases / genetics; Dogs; Female; Genetic Predisposition to Disease; Male; Pedigree; Spinocerebellar Degenerations / genetics; Spinocerebellar Degenerations / veterinary
TL;DR:
A hereditary cerebellar degenerative disorder with a relatively mild phenotype has emerged in the Scottish Terrier and genetic analysis results are consistent with an autosomal recessive mode of inheritance.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018
2010 journal article
Imaging diagnosis-neuronal ceroid lipofuscinosis with a chronic subdural hematoma
Veterinary Radiology & Ultrasound, 51(2), 155–158.
Source: NC State University Libraries
Added: August 6, 2018
2010 journal article
Mycophenolate mofetil treatment in dogs with serologically diagnosed acquired myasthenia gravis: 27 cases (1999-2008)
JAVMA-JOURNAL OF THE AMERICAN VETERINARY MEDICAL ASSOCIATION, 236(6), 664–668.
MeSH headings : Animals; Dog Diseases / drug therapy; Dog Diseases / mortality; Dogs; Drug Therapy, Combination; Enzyme Inhibitors / administration & dosage; Enzyme Inhibitors / adverse effects; Enzyme Inhibitors / therapeutic use; Female; Immunosuppressive Agents / administration & dosage; Immunosuppressive Agents / adverse effects; Immunosuppressive Agents / therapeutic use; Male; Myasthenia Gravis / drug therapy; Myasthenia Gravis / mortality; Myasthenia Gravis / veterinary; Mycophenolic Acid / administration & dosage; Mycophenolic Acid / adverse effects; Mycophenolic Acid / analogs & derivatives; Mycophenolic Acid / therapeutic use; Pyridostigmine Bromide / administration & dosage; Pyridostigmine Bromide / adverse effects; Pyridostigmine Bromide / therapeutic use; Retrospective Studies; Time Factors; Treatment Outcome
TL;DR:
The results did not support routine use of MMF for the treatment of dogs with acquired MG, and Megaesophagus, pneumonia, and low serum thyroid hormone concentration had no significant effect on time to remission or survival time for either treatment group.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018
2010 journal article
Prevalence of urinary tract infection in dogs after surgery for thoracolumbar intervertebral disc extrusion
Journal of Veterinary Internal Medicine, 24(5), 1106–1111.
Contributors: n , E. MacKillop, S. Cerda-Gonzalez *, S. Moore *, K. Muñana n , M. Grafinger*, J. Osborne, S. Vaden n
author keywords: Incontinence; Micturition; Spinal cord injury
MeSH headings : Animals; Dog Diseases / etiology; Dogs; Female; Intervertebral Disc Displacement / surgery; Intervertebral Disc Displacement / veterinary; Male; Risk Factors; Surgical Procedures, Operative / adverse effects; Surgical Procedures, Operative / veterinary; Urinary Tract Infections / etiology; Urinary Tract Infections / veterinary
TL;DR:
There is a high prevalence of UTIs, many of which are occult, in the 3 months after surgery for thoracolumbar IVDE, and these dogs should be routinely monitored for UTI with urine culture regardless of urinalysis results.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
Sources: Web Of Science, NC State University Libraries, ORCID
Added: August 6, 2018
2010 journal article
The Pathogenesis and Treatment of Acute Spinal Cord Injuries in Dogs
Veterinary Clinics of North America: Small Animal Practice, 40(5), 791–807.
author keywords: Spinal cord trauma; Infarct; Methylprednisolone; Polyethylene glycol; Primary damage; Secondary damage
MeSH headings : Acute Disease; Animals; Clinical Trials as Topic; Dogs / injuries; Female; Male; Mesenchymal Stem Cell Transplantation / veterinary; Myelitis / prevention & control; Myelitis / veterinary; Neuroprotective Agents / therapeutic use; Spinal Cord Injuries / pathology; Spinal Cord Injuries / therapy; Spinal Cord Injuries / veterinary; Spinal Cord Regeneration; Treatment Outcome
TL;DR:
There are currently no proven neuroprotective drug therapies for limiting secondary damage, but Transplantation with olfactory ensheathing cells and mesenchymal stem cells show promise, as do potassium channel antagonists.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
Sources: Crossref, NC State University Libraries, NC State University Libraries
Added: August 6, 2018
2009 journal article
CHARACTERISTICS OF CEREBROSPINAL FLUID FLOW IN CAVALIER KING CHARLES SPANIELS ANALYZED USING PHASE VELOCITY CINE MAGNETIC RESONANCE IMAGING
VETERINARY RADIOLOGY & ULTRASOUND, 50(5), 467–476.
author keywords: caudal occipital malformation syndrome; Chiari malformation; cine MRI; occipital hypoplasia; phase velocity contrast; syringohydromyelia
MeSH headings : Animals; Cerebrospinal Fluid / physiology; Dog Diseases / diagnosis; Dog Diseases / physiopathology; Dogs / physiology; Female; Foramen Magnum / physiopathology; Magnetic Resonance Imaging, Cine / veterinary; Male; Syringomyelia / physiopathology; Syringomyelia / veterinary
TL;DR:
Obstruction to flow at the foramen magnum is common in Cavalier King Charles Spaniels and CSF flow pattern and velocity are related to the presence of syringomyelia, which is unknown in dogs.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018
2009 journal article
Degenerative Myelopathy in 18 Pembroke Welsh Corgi Dogs
VETERINARY PATHOLOGY, 46(2), 241–250.
author keywords: Dogs; histochemistry; immunohistochemistry; myelopathy; neurodegeneration; spinal cord
MeSH headings : Animals; Axons / pathology; Dog Diseases / genetics; Dog Diseases / pathology; Dogs; Genetic Predisposition to Disease; Spinal Cord / cytology; Spinal Cord / pathology; Spinal Cord Diseases / genetics; Spinal Cord Diseases / pathology; Spinal Cord Diseases / veterinary
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018
2009 journal article
Genome-wide association analysis reveals a SOD1 mutation in canine degenerative myelopathy that resembles amyotrophic lateral sclerosis
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 106(8), 2794–2799.
MeSH headings : Amyotrophic Lateral Sclerosis / genetics; Amyotrophic Lateral Sclerosis / pathology; Animals; Base Sequence; DNA Primers; Disease Models, Animal; Dog Diseases / genetics; Dog Diseases / pathology; Dogs; Genome; Genome-Wide Association Study; Homozygote; Immunohistochemistry; Muscular Diseases / genetics; Muscular Diseases / pathology; Muscular Diseases / veterinary; Mutation, Missense; Polymerase Chain Reaction; Species Specificity; Superoxide Dismutase / genetics
TL;DR:
These findings identify canine DM to be the first recognized spontaneously occurring animal model for ALS.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
15. Life on Land
(Web of Science)
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018
2009 journal article
IDH1 and IDH2 hotspot mutations are not found in canine glioma
International Journal of Cancer, 127(1), 245–246.
Contributors: Z. Reitman *, n , C. Mariani n , R. Thomas n, M. Breen n , D. Bigner *, R. McLendon *, H. Yan *
MeSH headings : Animals; Brain Neoplasms / genetics; Brain Neoplasms / veterinary; Dogs; Glioma / genetics; Glioma / veterinary; Isocitrate Dehydrogenase / genetics; Isoenzymes / genetics; Mutation
TL;DR:
Human diffuse and anaplastic astrocytomas, well-differenti-ated and anaPLastic oligodendrogliomas and secondary glio-blastomas frequently contain somatic mutations of the R132 codon of the cytoplasmic NADPþ-dependent iso-citrate dehydrogenase (IDH1) or the corresponding R172codon in its homolog, IDH2.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, NC State University Libraries, Crossref, ORCID
Added: August 6, 2018
2009 journal article
Pharmacogenetic association study of 30 genes with phenobarbital drug response in epileptic dogs
Pharmacogenetics and Genomics, 19(12), 911–922.
Contributors: E. Kennerly n, Y. Idaghdour*, n , K. Munana n & G. Gibson*
author keywords: canine epilepsy; drug response; epoxide hydrolase; GABRA2; KCNQ3; pharmacogenetics; phenobarbital; SCN2A2
MeSH headings : Animals; Anticonvulsants / metabolism; Anticonvulsants / therapeutic use; Case-Control Studies; Dog Diseases / drug therapy; Dogs; Drug Resistance; Epilepsy / drug therapy; Epilepsy / veterinary; Pharmacogenetics; Phenobarbital / metabolism; Phenobarbital / therapeutic use; Polymorphism, Single Nucleotide
TL;DR:
Further replication and assessment of breed specificity is required before these markers can be considered as predictive of responsiveness to phenobarbital in dogs, but on functional grounds may tag strong candidate genes.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
Sources: Web Of Science, NC State University Libraries, Crossref, ORCID
Added: August 6, 2018
2009 journal article
Pharmacokinetics of 4-aminopyridine derivatives in dogs
JOURNAL OF VETERINARY PHARMACOLOGY AND THERAPEUTICS, 32(5), 485–491.
MeSH headings : 4-Aminopyridine / analogs & derivatives; 4-Aminopyridine / blood; 4-Aminopyridine / cerebrospinal fluid; 4-Aminopyridine / pharmacokinetics; Administration, Oral; Animals; Dogs; Dose-Response Relationship, Drug; Female; Male; Potassium Channel Blockers / administration & dosage; Potassium Channel Blockers / blood; Potassium Channel Blockers / cerebrospinal fluid; Potassium Channel Blockers / pharmacokinetics
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018
2009 journal article
Solitary Intracerebral Plasmacytoma in a Dog: Microscopic, Immunohistochemical, and Molecular Features
Veterinary Pathology, 46(5), 949–951.
author keywords: Brain neoplasia; canine; dogs; immunohistochemistry; plasma cell tumor; plasmacytoma; PCR
MeSH headings : Animals; Brain Neoplasms / pathology; Brain Neoplasms / veterinary; Dog Diseases / pathology; Dogs; Fatal Outcome; Female; Histocytochemistry / veterinary; Plasmacytoma / pathology; Plasmacytoma / veterinary; Seizures / pathology; Seizures / veterinary
TL;DR:
Although primary solitary intracerebral plasmacytoma is rare in dogs and other species, it should be included in the differential diagnosis for central nervous system round-cell neoplasms.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, Crossref, NC State University Libraries
Added: August 6, 2018
2009 journal article
‘Putting our heads together’: insights into genomic conservation between human and canine intracranial tumors
Journal of Neuro-Oncology, 94(3), 333–349.
Contributors: R. Thomas n, S. Duke n, H. Wang n, T. Breen n, R. Higgins *, K. Linder n, P. Ellis *, C. Langford*
author keywords: Comparative genomic hybridization; Canine; Brain tumor; Chromosome; Microarray
MeSH headings : Animals; Brain Neoplasms / genetics; Brain Neoplasms / pathology; Chromosome Aberrations; Chromosome Mapping; Chromosomes, Human, Pair 1; Chromosomes, Human, Pair 22; Cluster Analysis; Dogs; Female; Gene Expression Regulation, Neoplastic; Genome / genetics; Glioma / genetics; Glioma / pathology; Humans; In Situ Hybridization, Fluorescence; Male; Meningeal Neoplasms / genetics; Meningeal Neoplasms / pathology; Meningioma / genetics; Meningioma / pathology
TL;DR:
A microarray-based comparative genomic hybridization analysis of 60 spontaneous canine intracranial tumors was performed to examine the degree to which dog and human patients exhibit aberrations of ancestrally related chromosome regions, consistent with a shared pathogenesis.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
15. Life on Land
(OpenAlex)
Sources: Web Of Science, Crossref, NC State University Libraries, ORCID
Added: August 6, 2018
2008 article
MORPHOLOGY OF THE CAUDAL FOSSA IN CAVALIER KING CHARLES SPANIELS
VETERINARY RADIOLOGY & ULTRASOUND, Vol. 50, pp. 37–46.
author keywords: chiari-like; occipital hypoplasia; syringomyelia; MRI
MeSH headings : Animals; Arnold-Chiari Malformation / diagnosis; Arnold-Chiari Malformation / genetics; Arnold-Chiari Malformation / pathology; Arnold-Chiari Malformation / veterinary; Atlanto-Axial Joint / pathology; Atlanto-Occipital Joint / pathology; Breeding; Dog Diseases / diagnosis; Dog Diseases / genetics; Dog Diseases / pathology; Dogs; Female; Foramen Magnum / abnormalities; Foramen Magnum / anatomy & histology; Magnetic Resonance Imaging / methods; Magnetic Resonance Imaging / veterinary; Male; Syndrome; Syringomyelia / diagnosis; Syringomyelia / genetics; Syringomyelia / pathology; Syringomyelia / veterinary
TL;DR:
While several factors are associated with the presence of neurologic signs, occipital hypoplasia appears to be the most important factor.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018
2008 journal article
Managing acute spinal cord injuries
Compendium-Continuing Education for Veterinarians, 30(9), 496–504.
Source: NC State University Libraries
Added: August 6, 2018
2007 journal article
Clinical characterization of a familial degenerative myelopathy in Pembroke Welsh Corgi dogs
JOURNAL OF VETERINARY INTERNAL MEDICINE, 21(6), 1323–1331.
author keywords: ataxia; axonopathy; canine; neurodegenerative; oxidative stress; spinal cord
MeSH headings : Animals; DNA; Dog Diseases / genetics; Dogs; Female; Genetic Predisposition to Disease; Male; Pedigree; Spinal Cord Diseases / genetics; Spinal Cord Diseases / veterinary
TL;DR:
Clinical progression of FDM in PWC dogs was similar to that observed in other breeds but characterized by a longer duration, and pedigree analysis suggested a familial disease.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018
2007 journal article
Congenital Portosystemic shunts in five mature dogs with neurological signs
JOURNAL OF THE AMERICAN ANIMAL HOSPITAL ASSOCIATION, 43(6), 322–331.
MeSH headings : Age Factors; Animals; Dog Diseases / congenital; Dog Diseases / surgery; Dogs; Female; Hepatic Encephalopathy / congenital; Hepatic Encephalopathy / surgery; Hepatic Encephalopathy / veterinary; Male; Portal System / abnormalities; Portal System / surgery; Portal Vein / abnormalities; Portal Vein / surgery; Treatment Outcome
TL;DR:
All five dogs with congenital portosystemic shunts responded to medical or surgical treatment, demonstrating that older animals can respond to treatment even after exhibiting severe neurological signs.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018
2007 journal article
Intramedullary cavernous malformation of the spinal cord in two dogs
VETERINARY PATHOLOGY, 44(4), 528–532.
author keywords: cavernous hemangioma; hemorrhage; spinal cord; vascular malformation
MeSH headings : Animals; Dog Diseases / pathology; Dogs; Female; Male; Spinal Cord / abnormalities; Spinal Cord / blood supply; Spinal Cord / pathology
TL;DR:
CVMs appear to be an uncommon cause of both acute and chronic spinal cord disease in the dog.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018
2007 journal article
Neurologic dysfunction in hypothyroid, hyperlipidemic labrador retrievers
JOURNAL OF VETERINARY INTERNAL MEDICINE, 21(6), 1316–1322.
author keywords: atherosclerosis; hypercholesterolemia; hyperlipidemia; hypertriglyceridemia; hyperviscosity; hypothyroidism; iliac thrombosis; stroke; thromboembolism
MeSH headings : Animals; Atherosclerosis / complications; Atherosclerosis / veterinary; Central Nervous System Diseases / complications; Central Nervous System Diseases / veterinary; Dogs; Female; Hyperlipidemias / complications; Hyperlipidemias / veterinary; Hypothyroidism / complications; Hypothyroidism / veterinary; Male; Retrospective Studies
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
5. Gender Equality
(Web of Science)
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018
2006 journal article
Correlation between reverse transcriptase (TERT) expression and MIB-1 expression in canine brain tumors- an important animal model for developing telomerase based therapeutics
Neuropathology and Applied Neurobiology, 32, 662–673.
Source: NC State University Libraries
Added: September 9, 2019
2006 journal article
Fecal incontinence associated with epidural spinal hematoma and intervertebral disk extrusion in a dog
Journal of the American Veterinary Medical Association, 228(2), 230–235.
MeSH headings : Animals; Dog Diseases / diagnosis; Dog Diseases / diagnostic imaging; Dog Diseases / surgery; Dogs; Fecal Incontinence / etiology; Fecal Incontinence / veterinary; Hematoma, Epidural, Spinal / diagnosis; Hematoma, Epidural, Spinal / diagnostic imaging; Hematoma, Epidural, Spinal / surgery; Hematoma, Epidural, Spinal / veterinary; Intervertebral Disc Displacement / diagnosis; Intervertebral Disc Displacement / diagnostic imaging; Intervertebral Disc Displacement / surgery; Intervertebral Disc Displacement / veterinary; Lameness, Animal / etiology; Lameness, Animal / surgery; Magnetic Resonance Imaging / veterinary; Male; Radionuclide Imaging; Treatment Outcome
TL;DR:
Thoracolumbar spinal cord injuries can result in upper motor neuron fecal incontinence in ambulatory dogs and Epidural spinal hematomas may develop secondary to intervertebral disk herniations and cause spinal cord compression resulting in neurologic deficits.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, NC State University Libraries, Crossref
Added: August 6, 2018
2006 journal article
Femoral Neuropathy in a Dog with Iliopsoas Muscle Injury
Veterinary Surgery, 35(2), 186–190.
MeSH headings : Animals; Diagnosis, Differential; Dogs; Femoral Nerve / injuries; Femoral Nerve / surgery; Magnetic Resonance Imaging / veterinary; Male; Pain / diagnosis; Pain / etiology; Pain / veterinary; Psoas Muscles / injuries; Psoas Muscles / surgery; Treatment Outcome
TL;DR:
Iliopsoas muscle injury should be considered in patients with hip pain and MRI is a useful test for diagnosis, and tenectomy may be indicated for relief of chronic iliop soas muscle pain.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(OpenAlex)
Sources: Web Of Science, NC State University Libraries, Crossref
Added: August 6, 2018
2006 journal article
Intracranial vs extracranial seizures
NAVC Clinician's Brief, 4(6), 12.
Source: NC State University Libraries
Added: August 6, 2018
2006 journal article
Magnetic resonance imaging characteristics of peripheral nerve sheath tumors of the canine brachial plexus in 18 dogs
VETERINARY RADIOLOGY & ULTRASOUND, 48(1), 1–7.
author keywords: brachial plexus tumor; canine; magnetic resonance imaging; neurofibrosarcoma; peripheral nerve sheath tumor; schwannoma
MeSH headings : Animals; Brachial Plexus; Colorado; Dog Diseases / pathology; Dogs; Female; Magnetic Resonance Imaging / veterinary; Male; Nerve Sheath Neoplasms / pathology; Nerve Sheath Neoplasms / veterinary; Peripheral Nervous System Neoplasms / pathology; Peripheral Nervous System Neoplasms / veterinary; Records / veterinary; Retrospective Studies
TL;DR:
High resolution, smaller FOV, multiplanar examination of the cervicothoracic spine was important for appreciating nerve root and foraminal involvement, and Contrast enhancement was critical to detecting subtle diffuse nerve sheath involvement or small isointense nodules.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018
2006 journal article
Neuronal Ceroid Lipofuscinosis in a Vietnamese Pot-bellied Pig (Sus scrofa)
Veterinary Pathology, 43(4), 556–560.
author keywords: ceroid lipofuscinosis; pig; neurodegeneration; storage disease
MeSH headings : Animals; Brain / pathology; Central Nervous System Diseases / pathology; Central Nervous System Diseases / veterinary; Fatal Outcome; Histocytochemistry / veterinary; Neuronal Ceroid-Lipofuscinoses / pathology; Neuronal Ceroid-Lipofuscinoses / veterinary; Sus scrofa; Swine Diseases / pathology
TL;DR:
The neuronal ceroid ipofuscinoses are a group of heritable, neurodegenerative, storage diseases, typically with an autosomal recessive mode of inheritance, and to the authors' knowledge, this is the first report of the disease in a pig.
(via Semantic Scholar)
Sources: Crossref, NC State University Libraries
Added: September 20, 2020
2006 journal article
Seizure management in dogs
NAVC Clinician's Brief, 4(6), 7.
Source: NC State University Libraries
Added: August 6, 2018
2006 journal article
Value of a single-shot turbo spin-echo pulse sequence for assessing the architecture of the subarachnoid space and the constitutive nature of cerebrospinal fluid
VETERINARY RADIOLOGY & ULTRASOUND, 47(3), 254–259.
author keywords: cervical; half-Fourier acquisition single-shot turbo spin echo; magnetic resonance imaging; myelogram; shot turbo spin echo
MeSH headings : Animals; Cat Diseases / cerebrospinal fluid; Cat Diseases / pathology; Cats; Diagnosis, Differential; Dog Diseases / cerebrospinal fluid; Dog Diseases / pathology; Dogs; Encephalitis / complications; Encephalitis / pathology; Encephalitis / veterinary; Female; Lameness, Animal / etiology; Lumbar Vertebrae / pathology; Lymphoma, Non-Hodgkin / complications; Lymphoma, Non-Hodgkin / pathology; Lymphoma, Non-Hodgkin / veterinary; Magnetic Resonance Imaging / methods; Magnetic Resonance Imaging / veterinary; Male; Spinal Cord Neoplasms / complications; Spinal Cord Neoplasms / pathology; Spinal Cord Neoplasms / veterinary; Subarachnoid Space / pathology
TL;DR:
Although the resolution of the single-shot turbo spin-echo pulse sequence images is relatively poor compared with more conventional sequences, the qualitative information about the subarachnoid space and cerebrospinal fluid and the rapid acquisition time, make it a useful sequence to include in standard protocols of spinal magnetic resonance imaging.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018
2005 journal article
Adult-onset neurodegenerative diseases in dogs and cats
Veterinary Medicine, 100(2), 144-.
Source: NC State University Libraries
Added: August 6, 2018
2005 journal article
Microarray analysis of differentially expressed genes of primary tumors in the canine central nervous system
VETERINARY PATHOLOGY, 42(5), 550–558.
Contributors: S. Thomson n, E. Kennerly n, n , J. Mickelson *, D. Hoffmann *, P. Dickinson *, G. Gibson n, M. Breen n
author keywords: cDNA microarray; canine choroid plexus tumor; ependymoma; glial tumor; meningioma
MeSH headings : Animals; Astrocytoma / genetics; Astrocytoma / veterinary; Brain Neoplasms / genetics; Brain Neoplasms / veterinary; Dog Diseases / genetics; Dogs; Ependymoma / genetics; Ependymoma / veterinary; Female; Gene Expression Regulation, Neoplastic / genetics; Glioblastoma / genetics; Glioblastoma / veterinary; Male; Meningeal Neoplasms / genetics; Meningeal Neoplasms / veterinary; Meningioma / genetics; Meningioma / veterinary; Oligodendroglioma / genetics; Oligodendroglioma / veterinary; Oligonucleotide Array Sequence Analysis / veterinary; Papilloma / genetics; Papilloma / veterinary
TL;DR:
This report represents the first global gene expression analysis of different types of canine brain tumors by cDNA microarrays and might aid in the identification of potential candidate genes involved in tumor formation and progression.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
Sources: Web Of Science, NC State University Libraries, ORCID
Added: August 6, 2018
2005 journal article
Myokymia and neuromyotonia in a cat
Journal of the American Veterinary Medical Association, 227(10), 1608–1612.
MeSH headings : Animals; Cat Diseases / drug therapy; Cat Diseases / pathology; Cats; Electromyography / veterinary; Female; Isaacs Syndrome / drug therapy; Isaacs Syndrome / pathology; Isaacs Syndrome / veterinary; Myokymia / drug therapy; Myokymia / pathology; Myokymia / veterinary; Phenytoin / therapeutic use; Treatment Outcome
TL;DR:
A 6-year-old spayed female domestic shorthair cat was examined because of a 2-week history of rhythmic muscle movements and electromyography revealed a substantial decrease in the amount of spontaneous activity in previously affected muscles.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, NC State University Libraries, Crossref
Added: August 6, 2018
2005 journal article
Rehabilitation for the Neurologic Patient
Veterinary Clinics of North America: Small Animal Practice, 35(6), 1389–1409.
MeSH headings : Animal Diseases / therapy; Animals; Animals, Domestic; Central Nervous System / injuries; Immobilization / veterinary; Neuromuscular Diseases / therapy; Neuromuscular Diseases / veterinary; Peripheral Nervous System / injuries; Physical Therapy Modalities / veterinary; Prognosis; Range of Motion, Articular; Recovery of Function; Spinal Cord Injuries / therapy; Spinal Cord Injuries / veterinary; Treatment Outcome; Veterinary Medicine / methods
TL;DR:
The pathophysiology of injury and recovery in the central and peripheral nervous systems, assessment of the neurologic patient, data on the prognosis and expected course of recovery for a variety of different diseases, and rehabilitation exercises appropriate for neurologic patients are described.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Crossref, NC State University Libraries, NC State University Libraries
Added: August 6, 2018
2004 book
BSAVA manual of canine and feline neurology
Quedgeley: British Small Animal Veterinary Association.
Source: NC State University Libraries
Added: August 6, 2018
2004 journal article
Behavioural analysis of the efficacy of treatments for injuries to the spinal cord in animals
VETERINARY RECORD, 155(8), 225–230.
MeSH headings : Animals; Behavior, Animal / physiology; Cat Diseases / diagnosis; Cat Diseases / physiopathology; Cat Diseases / therapy; Cats; Disease Models, Animal; Dog Diseases / diagnosis; Dog Diseases / physiopathology; Dog Diseases / therapy; Dogs; Locomotion; Motor Activity; Neurologic Examination / methods; Neurologic Examination / veterinary; Rats; Recovery of Function; Species Specificity; Spinal Cord Injuries / physiopathology; Spinal Cord Injuries / therapy; Spinal Cord Injuries / veterinary; Treatment Outcome
TL;DR:
This review describes the methods suitable for evaluating the behavioural recovery of animals with spinal cord injuries, in either a clinical or a laboratory setting, both in the clinical and laboratory setting.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018
2004 journal article
Cerebellar cortical degeneration in adult American Staffordshire Terriers
JOURNAL OF VETERINARY INTERNAL MEDICINE, 18(2), 201–208.
Contributors: n , S. Blot *, J. Thibaud*, J. Phillips n, . D.P. O'Brien, J. Burr n, J. Berg, T. Brown n, M. Breen n
author keywords: cerebellar abiotrophy; dog; hereditary ataxia; Purkinje neuron
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, NC State University Libraries, ORCID
Added: August 6, 2018
2004 journal article
Comparison of regional gene expression differences in the brains of the domestic dog and human
Human Genomics, 1(6), 435.
MeSH headings : Animals; Cerebellum / physiology; Cerebral Cortex / physiology; Dogs / physiology; Evolution, Molecular; Gene Expression Profiling; Genetic Variation; Genetics, Population; Humans; Oligonucleotide Array Sequence Analysis; Phenotype; Pituitary Gland / physiology; Transcription, Genetic
TL;DR:
This study lays the foundation for detailed analysis of the population structure of transcriptional variation as it relates to cognitive and neurological phenotypes in the domestic dog.
(via Semantic Scholar)
Sources: Crossref, NC State University Libraries
Added: July 27, 2019
2004 journal article
Motor neuron disease: inherited and acquired
VETERINARY CLINICS OF NORTH AMERICA-SMALL ANIMAL PRACTICE, 34(6), 1403-+.
MeSH headings : Animals; Cat Diseases / diagnosis; Cat Diseases / genetics; Cat Diseases / therapy; Cats; Dog Diseases / diagnosis; Dog Diseases / genetics; Dog Diseases / therapy; Dogs; Genetic Predisposition to Disease; Motor Neuron Disease / diagnosis; Motor Neuron Disease / therapy; Motor Neuron Disease / veterinary
TL;DR:
Although motor neuron diseases are a complex and varied group of diseases, they can be divided roughly into three categories, the most common of which is amyotrophic lateral sclerosis (ALS), which are late-onset diseases of the upper (eg, corticospinal tract) and lower motor neuron.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018
2004 journal article
Recovery of pelvic limb function in dogs following acute intervertebral disc herniations
JOURNAL OF NEUROTRAUMA, 21(1), 49–59.
author keywords: dog; disc herniation; functional recovery; spinal cord compression; spinal cord trauma
MeSH headings : Animals; Disease Models, Animal; Dogs; Hindlimb / physiopathology; Intervertebral Disc Displacement / complications; Intervertebral Disc Displacement / physiopathology; Lumbosacral Region / physiopathology; Pelvis / pathology; Recovery of Function; Spinal Cord Injuries / etiology; Spinal Cord Injuries / physiopathology; Thoracic Vertebrae / physiopathology
TL;DR:
It is concluded that dogs with spontaneous disc herniations provide a useful model of acute spinal cord injury for clinical trials and are suitable for use in clinical trials on neuroprotective drugs.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
Sources: Web Of Science, NC State University Libraries, ORCID
Added: August 6, 2018
2004 journal article
Stabilisation of scoliosis in two koi (Cyprinus carpio)
VETERINARY RECORD, 155(4), 115–119.
MeSH headings : Animals; Bone Cements; Bone Screws / veterinary; Carps; Diagnosis, Differential; Female; Fish Diseases / diagnosis; Fish Diseases / diagnostic imaging; Fish Diseases / pathology; Fish Diseases / surgery; Polymethyl Methacrylate / administration & dosage; Scoliosis / diagnosis; Scoliosis / surgery; Scoliosis / veterinary; Tomography, X-Ray Computed
TL;DR:
Two koi (Cyprinus carpio) from the same pond developed similar lesions of scoliosis and appeared to improve after surgery, but they began to decline and died within three months.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
14. Life Below Water
(Web of Science; OpenAlex)
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018
2004 journal article
Ultrasonographic appearance of Dandy Walker-like Syndrome in a Boston terrier
Veterinary Radiology & Ultrasound, 45(4), 336–339.
Sources: NC State University Libraries, NC State University Libraries
Added: August 6, 2018
2003 journal article
Long-term functional outcome of dogs with severe injuries of the thoracolumbar spinal cord: 87 cases (1996–2001)
Journal of the American Veterinary Medical Association, 222(6), 762–769.
MeSH headings : Age Factors; Animals; Body Weight; Dog Diseases / physiopathology; Dog Diseases / surgery; Dogs; Female; Intervertebral Disc Displacement / physiopathology; Intervertebral Disc Displacement / surgery; Intervertebral Disc Displacement / veterinary; Laminectomy / veterinary; Lumbar Vertebrae; Male; Pain / veterinary; Paraplegia / etiology; Paraplegia / surgery; Paraplegia / veterinary; Prognosis; Recovery of Function; Retrospective Studies; Spinal Cord Injuries / physiopathology; Spinal Cord Injuries / surgery; Spinal Cord Injuries / veterinary; Thoracic Vertebrae; Treatment Outcome
TL;DR:
Results suggested that the prognosis for paraplegic dogs without DPP because of trauma was guarded, while dogs with disk herniation had a better chance of recovering motor function.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
Sources: Web Of Science, NC State University Libraries, ORCID, Crossref
Added: August 6, 2018
2003 journal article
Molecular genetic and expression analysis of alpha-tocopherol transfer protein mRNA in German shepherd dogs with degenerative myelopathy
Berliner Und Munchener Tierarztliche Wochenschrift (Berlin, Germany : 1949), 116(1-2), 31–36.
Source: NC State University Libraries
Added: August 6, 2018
2003 journal article
Molecular identification of Ehrlichia ewingii infection in dogs: 15 cases (1997-2001)
JOURNAL OF THE AMERICAN VETERINARY MEDICAL ASSOCIATION, 222(8), 1102–1107.
MeSH headings : Animals; Anti-Bacterial Agents / therapeutic use; DNA, Bacterial / blood; DNA, Bacterial / chemistry; Dog Diseases / diagnosis; Dog Diseases / drug therapy; Dog Diseases / microbiology; Dogs; Doxycycline / therapeutic use; Ehrlichia / genetics; Ehrlichia / isolation & purification; Ehrlichiosis / diagnosis; Ehrlichiosis / drug therapy; Ehrlichiosis / microbiology; Ehrlichiosis / veterinary; Female; Fever / microbiology; Fever / veterinary; Lameness, Animal / microbiology; Male; Polymerase Chain Reaction / methods; Polymerase Chain Reaction / veterinary; Retrospective Studies; Thrombocytopenia / microbiology; Thrombocytopenia / veterinary; Treatment Outcome
TL;DR:
PCR testing for E ewingii infection should be considered in dogs with fever, neutrophilic polyarthritis, unexplained ataxia or paresis, thrombocytopenia, or unexplained reactive lymphocytes, and indogs with clinical signs suggestive of ehrlichiosis that are seronegative for E canis.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018
2003 journal article
Relationship among basilar artery resistance index, degree of ventriculomegaly, and clinical signs in hydrocephalic dogs
VETERINARY RADIOLOGY & ULTRASOUND, 44(6), 687–694.
Contributors: M. Saito n, n , K. Spaulding n, K. Muñana n & N. Sharp n
author keywords: hydrocephalus; resistance index; ventriculomegaly; ultrasound
MeSH headings : Animals; Basilar Artery / physiopathology; Blood Flow Velocity / veterinary; Cerebrovascular Circulation; Dog Diseases / diagnostic imaging; Dog Diseases / physiopathology; Dogs; Female; Hydrocephalus / physiopathology; Hydrocephalus / veterinary; Male; Predictive Value of Tests; Pulsatile Flow; Sensitivity and Specificity; Severity of Illness Index; Ultrasonography, Doppler, Transcranial / methods; Vascular Resistance
TL;DR:
The results suggest that ultrasonographic measurement of VB ratio and basilar artery RI may allow identification of dogs with symptomatic hydrocephalus or dogs that are at risk of developing symptomatic Hydrocephalus.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
Sources: Web Of Science, NC State University Libraries, ORCID
Added: August 6, 2018
2003 journal article
Spinal arachnoid cysts in 17 dogs
JOURNAL OF THE AMERICAN ANIMAL HOSPITAL ASSOCIATION, 39(3), 271–282.
MeSH headings : Animals; Arachnoid Cysts / epidemiology; Arachnoid Cysts / veterinary; Cervical Vertebrae; Dog Diseases / diagnostic imaging; Dog Diseases / epidemiology; Dog Diseases / etiology; Dog Diseases / pathology; Dog Diseases / surgery; Dogs; Female; Magnetic Resonance Imaging / veterinary; Male; Myelography / veterinary; North Carolina / epidemiology; Records / veterinary; Retrospective Studies; Spinal Diseases / epidemiology; Spinal Diseases / veterinary; Spinal Fusion / veterinary; Thoracic Vertebrae
TL;DR:
The medical records of 17 dogs diagnosed with spinal arachnoid cysts at North Carolina State University Veterinary Teaching Hospital were retrospectively examined to identify trends in signalment, history, neurological status, treatment, and short- and long-term prognosis.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, NC State University Libraries, ORCID
Added: August 6, 2018
2003 article
Use of a multiplex polymerase chain reaction assay in the antemortem diagnosis of toxoplasmosis and neosporosis in the central nervous system of cats and dogs
Schatzberg, S. J., Haley, N. J., Barr, S. C., deLahunta, A., Olby, N., Munana, K., & Sharp, N. J. H. (2003, December). AMERICAN JOURNAL OF VETERINARY RESEARCH, Vol. 64, pp. 1507–1513.
Contributors: S. Schatzberg*, N. Haley, S. Barr, A. deLahunta, * , K. Munana* , N. Sharp
MeSH headings : Animals; Cats; Central Nervous System / parasitology; Coccidiosis / diagnosis; Coccidiosis / veterinary; DNA Primers; Dogs; Electrophoresis, Agar Gel; Neospora / genetics; Polymerase Chain Reaction / methods; Sequence Analysis, DNA; Toxoplasma / genetics; Toxoplasmosis, Animal / diagnosis
TL;DR:
The multiplex PCR assay with built-in control reactions could be a complementary clinical tool for the antemortem diagnosis of toxoplasmosis or neosporosis associated with the CNS.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, NC State University Libraries, ORCID
Added: August 6, 2018
2002 journal article
Cervical injury following a horse kick to the head in two dogs
JOURNAL OF THE AMERICAN ANIMAL HOSPITAL ASSOCIATION, 38(4), 321–326.
Contributors: n , K. Muñana n , L. De Risio n, P. Sebestyen n & B. Hansen n
MeSH headings : Animals; Brain Injuries / complications; Brain Injuries / diagnostic imaging; Brain Injuries / pathology; Brain Injuries / therapy; Brain Injuries / veterinary; Cervical Vertebrae / injuries; Diagnosis, Differential; Dogs / injuries; Emergency Treatment / veterinary; Female; Horses; Magnetic Resonance Imaging / veterinary; Male; Radiography; Respiration, Artificial / veterinary; Spinal Injuries / complications; Spinal Injuries / diagnostic imaging; Spinal Injuries / pathology; Spinal Injuries / therapy; Spinal Injuries / veterinary; Wounds, Nonpenetrating / complications; Wounds, Nonpenetrating / diagnostic imaging; Wounds, Nonpenetrating / pathology; Wounds, Nonpenetrating / therapy; Wounds, Nonpenetrating / veterinary
TL;DR:
Two dogs were presented to North Carolina State University Veterinary Teaching Hospital following blunt trauma to the head delivered by a horse kick and both had compromise to their upper airway as a result of indirect injury to the soft tissues of the neck, visible on plain radiographs.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
Sources: Web Of Science, NC State University Libraries, ORCID
Added: August 6, 2018
2002 journal article
Dorsal laminectomy for caudal cervical spondylomyelopathy: Postoperative recovery and long-term follow-up in 20 dogs
Veterinary Surgery, 31(5), 418–427.
Contributors: L. De Risio n, K. Muñana n , M. Murray n, n , N. Sharp n & P. Cuddon n
MeSH headings : Animals; Cervical Vertebrae / surgery; Colorado / epidemiology; Dog Diseases / mortality; Dog Diseases / surgery; Dogs; Female; Follow-Up Studies; Laminectomy / veterinary; Male; Neurologic Examination / veterinary; North Carolina / epidemiology; Postoperative Complications / veterinary; Records / veterinary; Recurrence; Retrospective Studies; Spinal Osteophytosis / mortality; Spinal Osteophytosis / surgery; Spinal Osteophytosis / veterinary; Treatment Outcome
TL;DR:
Dorsal cervical laminectomy is an effective treatment for CCSM in those dogs with dorsal compression or multiple sites of involvement and long-term outcome and recurrence rates were comparable to those seen with other surgical techniques for C CSM.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
Sources: NC State University Libraries, NC State University Libraries, ORCID
Added: August 6, 2018
2002 journal article
Muscle cramps in two standard poodles with hypoadrenocorticism
Journal of the American Animal Hospital Association, 38(5), 437–443.
MeSH headings : Adrenal Insufficiency / complications; Adrenal Insufficiency / drug therapy; Adrenal Insufficiency / veterinary; Animals; Desoxycorticosterone / analogs & derivatives; Desoxycorticosterone / therapeutic use; Dog Diseases / drug therapy; Dogs; Extremities; Female; Male; Muscle Cramp / complications; Muscle Cramp / drug therapy; Muscle Cramp / veterinary
TL;DR:
It is concluded that hypoadrenocorticism can be associated with episodes of painful muscle cramps in standard poodles and altering treatment to desoxycorticosterone pivalate resolved the electrolyte abnormalities and the episodes of muscle cramping in both dogs.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: NC State University Libraries, NC State University Libraries
Added: August 6, 2018
2002 article
Use of vagal nerve stimulation as a treatment for refractory epilepsy in dogs
Munana, K. R., Vitek, S. M., Tarver, W. B., Saito, M., Skeen, T. M., Sharp, N. J. H., … Haglund, M. M. (2002, October 1). JOURNAL OF THE AMERICAN VETERINARY MEDICAL ASSOCIATION, Vol. 221, pp. 977–983.
Contributors: K. Muñana n , S. Vitek n, W. Tarver n, M. Saito n, T. Skeen n, N. Sharp n, n , M. Haglund n
MeSH headings : Animals; Cross-Over Studies; Dog Diseases / therapy; Dogs; Electric Stimulation Therapy / adverse effects; Electric Stimulation Therapy / methods; Electric Stimulation Therapy / veterinary; Epilepsy / therapy; Epilepsy / veterinary; Female; Male; Pacemaker, Artificial / veterinary; Safety; Seizures / prevention & control; Seizures / veterinary; Treatment Outcome; Vagus Nerve / physiopathology
TL;DR:
Vagal nerve stimulation is a potentially safe approach to seizure control that appears to be efficacious in certain dogs and should be considered a possible treatment option when antiepileptic medications are ineffective.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
Sources: Web Of Science, NC State University Libraries, ORCID
Added: August 6, 2018
2001 journal article
Development of a functional scoring system in dogs with acute spinal cord injuries
AMERICAN JOURNAL OF VETERINARY RESEARCH, 62(10), 1624–1628.
Contributors: n , L. De Risio n, K. Muñana n , M. Wosar n, T. Skeen n, N. Sharp n, B. Keene n
MeSH headings : Animals; Dog Diseases / physiopathology; Dogs; Gait / physiology; Hindlimb / physiopathology; Intervertebral Disc Displacement / physiopathology; Intervertebral Disc Displacement / veterinary; Observer Variation; Paraplegia / etiology; Paraplegia / veterinary; Reproducibility of Results; Severity of Illness Index; Spinal Cord Diseases / complications; Spinal Cord Diseases / physiopathology; Spinal Cord Diseases / veterinary; Statistics, Nonparametric; Videotape Recording
TL;DR:
Pelvic limb gait of dogs recovering from thoracolumbar spinal cord injuries can be reliably quantified, using a numeric scale, and this scale will facilitate the performance of clinical trials aimed at improving the outcome of acute spinal Cord injuries.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
Sources: Web Of Science, NC State University Libraries, ORCID
Added: August 6, 2018
2001 journal article
Evaluation of the dystrophin-glycoprotein complex, alpha-actinin, dysferlin and calpain 3 in an autosomal recessive muscular dystrophy in Labrador retrievers
NEUROMUSCULAR DISORDERS, 11(1), 41–49.
author keywords: autosomal recessive muscular dystrophy in Labrador retrievers; limb-girdle muscular dystrophy; congenital muscular dystrophy; sarcoglycan; merosin; calpain 3; dysferlin
MeSH headings : Actinin / metabolism; Animals; Calpain / metabolism; Dog Diseases / metabolism; Dog Diseases / pathology; Dog Diseases / physiopathology; Dogs; Dysferlin; Dystrophin / metabolism; Female; Genes, Recessive / genetics; Glycoproteins / metabolism; Male; Membrane Proteins; Muscle Proteins / metabolism; Muscle, Skeletal / metabolism; Muscle, Skeletal / pathology; Muscle, Skeletal / physiopathology; Muscular Dystrophy, Animal / metabolism; Muscular Dystrophy, Animal / pathology; Muscular Dystrophy, Animal / physiopathology
TL;DR:
The results demonstrate that dystrophin, the sarcoglycans, alpha-actinin, dysferlin and calpain 3 are present in the normal and affected dogs, and it is concluded that this autosomal recessive muscular dystrophy is not due to a deficiency ofalpha-act inin, or any of the known autosome recessive limb-girdle muscular dystroke proteins, although it cannot rule out a malfunction of any of these proteins.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018
2001 journal article
Identification of arachnoid cysts in the quadrigeminal cistern using ultrasonography
VETERINARY RADIOLOGY & ULTRASOUND, 42(5), 435–439.
MeSH headings : Animals; Arachnoid Cysts / diagnostic imaging; Arachnoid Cysts / veterinary; Breeding; Diagnosis, Differential; Dog Diseases / diagnostic imaging; Dogs; Female; Male; Tectum Mesencephali / diagnostic imaging; Ultrasonography, Doppler, Transcranial / veterinary
TL;DR:
In transverse, dorsal and sagittal transcranial ultrasound images there was marked dilation of the lateral ventricles and a well-defined, oval to triangular-shaped anechoic area between the caudal aspect of the occipital lobes, dorsal to the midbrain, and rostral to the cerebellum, consistent with a diagnosis of concurrent hydrocephalus and an arachnoid cyst within the quadrigeminal cistern.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018
2001 journal article
Intervertebral disk disease in 10 cats
JOURNAL OF THE AMERICAN ANIMAL HOSPITAL ASSOCIATION, 37(4), 384–389.
MeSH headings : Animals; Cat Diseases / diagnostic imaging; Cat Diseases / epidemiology; Cat Diseases / pathology; Cats; Female; Intervertebral Disc; Lumbar Vertebrae; Male; North Carolina / epidemiology; Radiography; Records / veterinary; Retrospective Studies; Spinal Diseases / diagnostic imaging; Spinal Diseases / epidemiology; Spinal Diseases / pathology; Spinal Diseases / veterinary
TL;DR:
The medical records of 10 cats diagnosed with intervertebral disk disease were reviewed, and all cats judged to have an excellent outcome had undergone surgical decompression.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
Sources: Web Of Science, NC State University Libraries, ORCID
Added: August 6, 2018
2001 article
Predictors of outcome after dorsal decompressive laminectomy for degenerative lumbosacral stenosis in dogs: 69 cases (1987-1997)
De Risio, L., Sharp, N. J. H., Olby, N. J., Munana, K. R., & Thomas, W. B. (2001, September 1). JOURNAL OF THE AMERICAN VETERINARY MEDICAL ASSOCIATION, Vol. 219, pp. 624–628.
Contributors: L. De Risio *, N. Sharp, * , K. Muñana* & W. Thomas
MeSH headings : Animals; Decompression, Surgical / veterinary; Dog Diseases / surgery; Dogs; Female; Follow-Up Studies; Laminectomy / veterinary; Lumbosacral Region / surgery; Male; Medical Records; Prognosis; Retrospective Studies; Spinal Stenosis / complications; Spinal Stenosis / surgery; Spinal Stenosis / veterinary; Surveys and Questionnaires; Treatment Outcome; Urinary Incontinence / complications; Urinary Incontinence / veterinary
TL;DR:
Decompressive laminectomy is an effective treatment for DLSS, although dogs with urinary or fecal incontinence have a worse prognosis than dogs that are continent before surgery.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, NC State University Libraries, ORCID
Added: August 6, 2018
2001 journal article
Risk factors for development of status epilepticus in dogs with idiopathic epilepsy and effects of status epilepticus on outcome and survival time: 32 cases (1990-1996)
JOURNAL OF THE AMERICAN VETERINARY MEDICAL ASSOCIATION, 219(5), 618–623.
Contributors: M. Saito n, K. Muñana n , N. Sharp n & n
MeSH headings : Animals; Anticonvulsants / therapeutic use; Body Weight; Dog Diseases / diagnosis; Dog Diseases / etiology; Dog Diseases / mortality; Dogs; Epilepsy / complications; Epilepsy / mortality; Epilepsy / veterinary; Female; Male; Records / veterinary; Retrospective Studies; Risk Factors; Seizures / complications; Seizures / mortality; Seizures / veterinary; Status Epilepticus / etiology; Status Epilepticus / mortality; Status Epilepticus / veterinary; Treatment Outcome
TL;DR:
Results suggest that a substantial percentage of dogs with idiopathic epilepsy will have episodes of SE, and dogs with greater body weights were more likely to have episodes, and early appropriate seizure treatment did not appear to decrease the risk that dogs would have episodes.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
Sources: Web Of Science, NC State University Libraries, ORCID
Added: August 6, 2018
2000 journal article
The computed tomographic appearance of acute thoracolumbar intervertebral disk herniations in dogs.
Veterinary Radiology Ultrasound, 41(5), 396–402.
Contributors: n , K. Muñana , N. Sharp n & D. Thrall n
author keywords: intervertebral disc herniation; computed tomography; myelography; epidural hemorrhage; dog
MeSH headings : Animals; Diskectomy; Dog Diseases / diagnostic imaging; Dog Diseases / surgery; Dogs; Hematoma, Epidural, Cranial / veterinary; Intervertebral Disc Displacement / diagnostic imaging; Intervertebral Disc Displacement / surgery; Intervertebral Disc Displacement / veterinary; Myelography; Spinal Cord / pathology; Tomography, X-Ray Computed
TL;DR:
In dogs with a long standing history of disc herniations, disc material identified in the vertebral canal had a more hyperattenuating and homogeneous appearance than recently herniated disc material.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, NC State University Libraries, ORCID, Crossref
Added: August 6, 2018
2000 journal article
Tumoral calcinosis of the thoracic spine: a case report
Veterinary Neurology and Neurosurgery. https://www.vin.com/apputil/content/defaultadv1.aspx?id=3857015&pid=11157
Source: NC State University Libraries
Added: September 20, 2020
1999 journal article
A polymerase chain reaction screening strategy for the promoter of the canine dystrophin gene
American Journal of Veterinary Research, 60(9), 1040–1046.
Source: NC State University Libraries
Added: August 6, 2018
1999 journal article
Chronic and Acute Compressive Spinal Cord Lesions in Dogs due to Intervertebral Disc Herniation Are Associated With Elevation in Lumbar Cerebrospinal Fluid Glutamate Concentration
Journal of Neurotrauma, 16(12), 1215–1224.
author keywords: cerebrospinal fluid; dog; excitotoxicity; glutamate; spinal-cord compression; spinal cord injury
MeSH headings : Acute Disease; Animals; Chronic Disease; Dogs; Glutamic Acid / cerebrospinal fluid; Intervertebral Disc Displacement / complications; Lumbar Vertebrae; Lumbosacral Region; Osmolar Concentration; Reference Values; Spinal Cord Injuries / cerebrospinal fluid; Spinal Cord Injuries / etiology; Thoracic Vertebrae
TL;DR:
Dogs with chronic compressive thoracolumbar lesions have a two-fold elevation of CSF glutamate concentration, suggesting that excitotoxicity may also be a component of chronic spinal cord compression.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, NC State University Libraries, ORCID, Crossref
Added: August 6, 2018
1999 review
Current concepts in the management of acute spinal cord injury
[Review of ]. JOURNAL OF VETERINARY INTERNAL MEDICINE, 13(5), 399–407.
author keywords: disk disease; methylprednisolone; secondary injury; spinal cord trauma; thyrotropin-releasing hormone
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018
1999 journal article
Molecular analysis of a spontaneous dystrophin 'knockout' dog
NEUROMUSCULAR DISORDERS, 9(5), 289–295.
Contributors: S. Schatzberg n, * , M. Breen* , L. Anderson, C. Langford, H. Dickens, S. Wilton, C. Zeiss
author keywords: dystrophin; Duchenne muscular dystrophy; canine; animal models; fluorescence in situ hybridization; polymerase chain reaction
MeSH headings : Animals; Biopsy; Blotting, Western; Chromosome Deletion; Creatine Kinase / blood; DNA / genetics; Disease Models, Animal; Dog Diseases / genetics; Dog Diseases / pathology; Dogs; Dystrophin / genetics; In Situ Hybridization, Fluorescence; Male; Muscle, Skeletal / metabolism; Muscle, Skeletal / pathology; Muscular Dystrophy, Animal / genetics; Muscular Dystrophy, Animal / pathology; Mutation; Polymerase Chain Reaction; X Chromosome / genetics
TL;DR:
The molecular basis for skeletal myopathy and dilated cardiomyopathy in two male German short-haired pointer (GSHP) littermates is determined and a visible deletion in the p21 region of the affected canine X chromosome is confirmed.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, NC State University Libraries, ORCID
Added: August 6, 2018
1997 journal article
Suspected mitochondrial myopathy in a Jack Russell terrier
JOURNAL OF SMALL ANIMAL PRACTICE, 38(5), 213–216.
MeSH headings : Animals; Dog Diseases / physiopathology; Dogs; Female; Lactic Acid / metabolism; Mitochondrial Myopathies / diagnosis; Mitochondrial Myopathies / physiopathology; Mitochondrial Myopathies / veterinary; Muscle Fibers, Skeletal / ultrastructure; Physical Conditioning, Animal / physiology
TL;DR:
A tentative diagnosis of mitochondrial myopathy was made in a Jack Russell terrier with a history of progressive exercise intolerance and stunted, thin dog with a stilted gait, indicating a metabolic abnormality.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
2. Zero Hunger
(OpenAlex)
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018
1996 journal article
A New Method of Quantifying the Extent of Tissue Loss Following Spinal Cord Injury in the Rat
Experimental Neurology, 138(1), 82–92.
MeSH headings : Animals; Male; Rats; Spinal Cord / anatomy & histology; Spinal Cord Injuries / diagnosis; Spinal Cord Injuries / pathology; Time Factors
TL;DR:
The results demonstrate that the preinjury area of the cord must be established in order to calculate the full extent of tissue destruction and that it can be estimated accurately using the method described in this study.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(OpenAlex)
Sources: Crossref, NC State University Libraries
Added: July 27, 2019
1996 journal article
Primary demyelination and regeneration of ascending axons in the dorsal funiculus of the rat spinal cord following photochemically induced injury
Journal of Neurocytology, 25(1), 465–480.
MeSH headings : Animals; Axons / pathology; Axons / physiology; Axons / ultrastructure; Male; Microscopy, Electron; Nerve Degeneration; Nerve Fibers, Myelinated / pathology; Nerve Fibers, Myelinated / physiology; Nerve Fibers, Myelinated / ultrastructure; Nerve Regeneration; Oligodendroglia / pathology; Oligodendroglia / physiology; Photochemistry; Rats; Rats, Inbred Strains; Schwann Cells / pathology; Schwann Cells / physiology; Spinal Cord / pathology; Spinal Cord / physiopathology; Spinal Cord Injuries / pathology; Spinal Cord Injuries / physiopathology; Time Factors
TL;DR:
The extent of primary demyelination and regeneration of ascending axons in the dorsal funiculus of the rat spinal cord was investigated following photochemically-induced ischaemic injury and it is concluded that sub-pial axons at the lesion centre are demyelsinated between 4 and 7 days after injury and subsequently remyelinated by Schwann cells.
(via Semantic Scholar)
Sources: Crossref, NC State University Libraries
Added: July 27, 2019
1996 journal article
Reconstruction of the glial environment of a photochemically induced lesion in the rat spinal cord by transplantation of mixed glial cells
Journal of Neurocytology, 25(1), 481–498.
MeSH headings : Animals; Animals, Newborn; Astrocytes / cytology; Astrocytes / pathology; Astrocytes / physiology; Axons / physiology; Cats; Cell Line; Cell Survival; Coculture Techniques; Nerve Regeneration; Neuroglia / pathology; Neuroglia / physiology; Neuroglia / transplantation; Photochemistry; Rats; Rats, Inbred Strains; Spinal Cord Injuries / pathology; Spinal Cord Injuries / physiopathology; Spinal Cord Injuries / therapy; Transplantation, Heterologous
TL;DR:
O-2A progenitorderived astrocytes are more suitable for reconstruction of the glial environment of a cystic lesion in the rat spinal cord than ‘type-1 like’ astroCytes and would therefore be the cell of choice to engineer to produce factors that promote axonal regeneration.
(via Semantic Scholar)
Sources: Crossref, NC State University Libraries
Added: July 27, 2019
1995 journal article
Quadriceps muscle hypoplasia causing congenital lameness in Holstein calves
Veterinary Record, 136(18), 476–476.
MeSH headings : Animals; Cattle / injuries; Cattle Diseases / congenital; Female; Lameness, Animal / congenital; Muscle, Skeletal / abnormalities; Muscular Diseases / congenital; Muscular Diseases / veterinary
Sources: Crossref, NC State University Libraries
Added: September 20, 2020
1995 journal article
The Use of Transplanted Glial Cells to Reconstruct Glial Environments in the CNS
Brain Pathology, 5(4), 443–450.
MeSH headings : Animals; Astrocytes / physiology; Astrocytes / transplantation; Axons / physiology; Central Nervous System / surgery; Demyelinating Diseases / pathology; Demyelinating Diseases / physiopathology; Demyelinating Diseases / surgery; Nerve Regeneration; Neuroglia / transplantation
TL;DR:
Progenitor‐derived astrocytes show a greater ability to fill glia‐free areas than tissue culture astroCytes, although axons do not regenerate into the reconstituted area when introduced into infarcted white matter in the spinal cord.
(via Semantic Scholar)
Sources: Crossref, NC State University Libraries
Added: July 27, 2019
1995 journal article
The effect of injection technique on the passive spread of cells immediately following transplantation into rat spinal cord white matter tracts.
Restorative Neurology and Neuroscience, 7, 171–174.
Source: NC State University Libraries
Added: September 9, 2019
1994 journal article
Central core myopathy in a great dane
Journal of Small Animal Practice, 35(2), 100–103.
TL;DR:
An eight-month-old female great dane was referred for investigation of exercise intolerance that had developed progressively over one month, and the condition was diagnosed as a central core myopathy.
(via Semantic Scholar)
Sources: Crossref, NC State University Libraries
Added: July 7, 2020
1994 journal article
Correlation of plain radiographic and lumbar myelographic findings with surgical findings in thoracolumbar disc disease
Journal of Small Animal Practice, 35(7), 345–350.
TL;DR:
The results of a prospective study to compare the plain radiographic and lumbar myelographic findings with the surgical findings in 70 cases of suspected thoracolumbar disc protrusion in the dog are reported, assessing the relative accuracy of disc lesion localisation using plain and contrast radiography.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(OpenAlex)
Sources: Crossref, NC State University Libraries
Added: July 27, 2019
1992 journal article
Sensory neuropathy in a Jack Russell terrier
Journal of Small Animal Practice, 33(8), 402–404.
TL;DR:
A six-year-old male Jack Russell terrier was referred for investigation of an abnormal hindlimb stance and unresolving lesion on the dorsum of the right hindfoot, which was diagnosed as a sensory neuropathy, a disorder previously unrecognised in this breed.
(via Semantic Scholar)
Sources: Crossref, NC State University Libraries
Added: September 13, 2020
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