Nikolette L. McCombs

MeSH headings : Amino Acid Motifs; Animals; Benzimidazoles / chemistry; Benzimidazoles / metabolism; Benzimidazoles / toxicity; Catalytic Domain; Computational Biology; Environmental Pollutants / chemistry; Environmental Pollutants / metabolism; Environmental Pollutants / toxicity; Enzyme Inhibitors / chemistry; Enzyme Inhibitors / metabolism; Enzyme Inhibitors / toxicity; Fungicides, Industrial / chemistry; Fungicides, Industrial / metabolism; Fungicides, Industrial / toxicity; Hemoglobins / antagonists & inhibitors; Hemoglobins / chemistry; Hemoglobins / metabolism; Hydrogen Bonding; Hydrophobic and Hydrophilic Interactions; Imidazoles / chemistry; Imidazoles / metabolism; Imidazoles / toxicity; Indazoles / chemistry; Indazoles / metabolism; Indazoles / toxicity; Isoenzymes / antagonists & inhibitors; Isoenzymes / chemistry; Isoenzymes / metabolism; Kinetics; Ligands; Models, Molecular; Peroxidases / antagonists & inhibitors; Peroxidases / chemistry; Peroxidases / metabolism; Pesticides / chemistry; Pesticides / metabolism; Pesticides / toxicity; Polychaeta / enzymology; Recombinant Fusion Proteins / chemistry; Recombinant Fusion Proteins / metabolism; Recombinant Proteins / chemistry; Recombinant Proteins / metabolism; Triazoles / chemistry; Triazoles / metabolism; Triazoles / toxicity

TL;DR: The results demonstrate a new mechanism by which azole pollutants can potentially disrupt hemoglobin function, thereby improving the understanding of their impact on infaunal organisms in marine and aquatic environments. (via Semantic Scholar)

TL;DR: The results demonstrate the breadth of chemical reactivity afforded by dehaloperoxidase, and provide further evidence for establishing DHP as a multifunctional globin with practical applications as a biocatalyst. (via Semantic Scholar)