Nikolette L. McCombs

Works (2)

Updated: July 5th, 2023 15:36

2017 journal article

Interaction of Azole-Based Environmental Pollutants with the Coelomic Hemoglobin from Amphitrite ornata: A Molecular Basis for Toxicity

Biochemistry, 56(17), 2294–2303.

By: N. McCombs n, T. Moreno-Chicano, L. Carey n, S. Franzen n , M. Hough & R. Ghiladi n 

Contributors: N. McCombs n, T. Moreno-Chicano, L. Carey n, S. Franzen n , M. Hough & R. Ghiladi n 

MeSH headings : Amino Acid Motifs; Animals; Benzimidazoles / chemistry; Benzimidazoles / metabolism; Benzimidazoles / toxicity; Catalytic Domain; Computational Biology; Environmental Pollutants / chemistry; Environmental Pollutants / metabolism; Environmental Pollutants / toxicity; Enzyme Inhibitors / chemistry; Enzyme Inhibitors / metabolism; Enzyme Inhibitors / toxicity; Fungicides, Industrial / chemistry; Fungicides, Industrial / metabolism; Fungicides, Industrial / toxicity; Hemoglobins / antagonists & inhibitors; Hemoglobins / chemistry; Hemoglobins / metabolism; Hydrogen Bonding; Hydrophobic and Hydrophilic Interactions; Imidazoles / chemistry; Imidazoles / metabolism; Imidazoles / toxicity; Indazoles / chemistry; Indazoles / metabolism; Indazoles / toxicity; Isoenzymes / antagonists & inhibitors; Isoenzymes / chemistry; Isoenzymes / metabolism; Kinetics; Ligands; Models, Molecular; Peroxidases / antagonists & inhibitors; Peroxidases / chemistry; Peroxidases / metabolism; Pesticides / chemistry; Pesticides / metabolism; Pesticides / toxicity; Polychaeta / enzymology; Recombinant Fusion Proteins / chemistry; Recombinant Fusion Proteins / metabolism; Recombinant Proteins / chemistry; Recombinant Proteins / metabolism; Triazoles / chemistry; Triazoles / metabolism; Triazoles / toxicity
topics (OpenAlex): Biochemical effects in animals; Hemoglobin structure and function; Free Radicals and Antioxidants
TL;DR: The results demonstrate a new mechanism by which azole pollutants can potentially disrupt hemoglobin function, thereby improving the understanding of their impact on infaunal organisms in marine and aquatic environments. (via Semantic Scholar)
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14. Life Below Water (OpenAlex)
Sources: Web Of Science, NC State University Libraries, ORCID, Crossref
Added: August 6, 2018

2017 article

Oxidation of pyrrole by dehaloperoxidase-hemoglobin: chemoenzymatic synthesis of pyrrolin-2-ones

McCombs, N. L., Smirnova, T., & Ghiladi, R. A. (2017, January 1). Catalysis Science & Technology, Vol. 7, pp. 3104–3118.

By: N. McCombs n, T. Smirnova n  & R. Ghiladi n 

topics (OpenAlex): Porphyrin and Phthalocyanine Chemistry; Hemoglobin structure and function; Metal-Catalyzed Oxygenation Mechanisms; Porphyrin Metabolism and Disorders
TL;DR: The results demonstrate the breadth of chemical reactivity afforded by dehaloperoxidase, and provide further evidence for establishing DHP as a multifunctional globin with practical applications as a biocatalyst. (via Semantic Scholar)
UN Sustainable Development Goals Color Wheel
UN Sustainable Development Goal Categories
Sources: Web Of Science, ORCID, NC State University Libraries
Added: August 6, 2018

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