Noor Mohammad is an Assistant Professor at Bangladesh University of Engineering and Technology (BUET). He received his Ph.D. in Chemical and Biomolecular Engineering from NC State University, USA. Prior to his Ph.D., Dr. Mohammad completed his undergraduate and master’s degrees at BUET. After graduating with a B.Sc. in 2016, he served as a lecturer in the same department. He was awarded the prestigious Prime Minister’s Gold Medal for securing the top position in the Engineering Faculty at BUET. During his time at NC State, Dr. Mohammad conducted extensive research on developing novel CRISPR-based biosensing strategies for point-of-care diagnostics of animal and plant diseases. He developed multiple low-cost, label-free CRISPR diagnostic platforms, including a DNA sizing-based λ DNA reporting scheme, a hybrid reporter, and a supercoil plasmid DNA reporter. His work has been recognized by leading journals such as Nucleic Acids Research, Angewandte Chemie, Communications Chemistry, and CRISPR Journal, demonstrating his deep engagement with cutting-edge research in the field. He also received several accolades, including the Provost Doctoral Fellowship, Vivian T. Fellowship, College of Engineering Graduate Merit Award, and Scholar of the Year in Research (the highest recognition a Ph.D. student can receive from the university). Currently, he is dedicated to advancing his research on developing low-cost point-of-care biosensing devices for detecting infectious pathogens (such as HIV) with minimal instrumentation to make diagnostics accessible to all.
Works (11)
Updated: November 23rd, 2024 07:25
2024 article
Adeno-associated virus genome quantification with amplification-free CRISPR-Cas12a
Hetzler, Z., Marinakos, S. M., Lott, N., Mohammad, N., Lass-Napiorkowska, A., Kolbe, J., … Wei, Q. (2024, March 25). GENE THERAPY, Vol. 3.
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, NC State University Libraries
Added: April 15, 2024
2024 journal article
Disease Progress and Detection of a California Resistance-Breaking Strain of Tomato Spotted Wilt Virus in Tomato with LAMP and CRISPR-Cas12a Assays
PHYTOFRONTIERS, 4(1), 50–60.
author keywords: LAMP/CRISPR/Cas12a; resistance-breaking strain; tomato; TSWV
open access via doi.org (publisher)
Sources: Web Of Science, NC State University Libraries
Added: November 18, 2024
2024 article
Liquid Metal-Based Biosensors: Fundamentals and Applications
Jamalzadegan, S., Kim, S., Mohammad, N., Koduri, H., Hetzler, Z., Lee, G., … Wei, Q. (2024, January 23). ADVANCED FUNCTIONAL MATERIALS, Vol. 1.
author keywords: biosensors; liquid metals; wearable sensors; soft materials; precision health; point-of-care
TL;DR:
The recent progress of LM‐based biosensors for personalized healthcare and disease monitoring via both physical and biochemical signaling is survey and the challenges and future directions of LM‐integrated biosensor platforms is discussed.
(via Semantic Scholar)
Sources: Web Of Science, NC State University Libraries, ORCID
Added: February 12, 2024
2024 journal article
Ratiometric nonfluorescent CRISPR assay utilizing Cas12a-induced plasmid supercoil relaxation
COMMUNICATIONS CHEMISTRY, 7(1).
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, NC State University Libraries, ORCID
Added: June 24, 2024
2023 article
CRISPR-Cas Biochemistry and CRISPR-Based Molecular Diagnostics
Weng, Z., You, Z., Yang, J., Mohammad, N., Lin, M., Wei, Q., … Zhang, Y. (2023, February 14). ANGEWANDTE CHEMIE-INTERNATIONAL EDITION, Vol. 2.
author keywords: Amplification-Free Detection; Biosensors; CRISPR-Cas Biochemistry; Molecular Diagnostics; SARS-Cov-2
MeSH headings : Humans; COVID-19; CRISPR-Cas Systems; Pathology, Molecular; SARS-CoV-2; MicroRNAs; Biosensing Techniques; COVID-19 Testing
TL;DR:
Four ongoing research hotspots in molecular diagnostics-target preamplification-free detection, microRNA (miRNA) detection, non-nucleic-acid detection, and SARS-CoV-2 detection-are also covered.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, NC State University Libraries
Added: March 13, 2023
2023 article
Unidirectional trans-cleaving behavior of CRISPR-Cas12a unlocks for an ultrasensitive assay using hybrid DNA reporters containing a 3' toehold
Mohammad, N., Talton, L., Hetzler, Z., Gongireddy, M., & Wei, Q. (2023, August 31). NUCLEIC ACIDS RESEARCH, Vol. 8.
TL;DR:
This study not only unfolded new insight into the trans-cleavage behavior of Cas12a but also demonstrated a sensitive CRISPR-Cas12a assay by using a hybrid dsDNA reporter molecule.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, NC State University Libraries, ORCID
Added: September 18, 2023
2022 article
A Sensitive and Nonoptical CRISPR Detection Mechanism by Sizing Double-Stranded lambda DNA Reporter
Mohammad, N., Katkam, S. S., & Wei, Q. (2022, November 10). ANGEWANDTE CHEMIE-INTERNATIONAL EDITION, Vol. 11.
author keywords: Biosensors; CRISPR-Cas12a; DNA Sizing; DNA-Cleavage; lambda DNA
MeSH headings : CRISPR-Cas Systems; DNA; DNA Cleavage; DNA, Single-Stranded; Biosensing Techniques
TL;DR:
A simple, inexpensive, nonoptical, and sensitive CRISPR‐Cas12a‐based sensing platform to detect ssDNA targets by sizing double‐stranded λ DNA as novel report molecules, unlocking the possibility of using a variety of dsDNA asCRISPR reporters.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, ORCID, NC State University Libraries
Added: November 21, 2022
2022 journal article
A Sensitive and Nonoptical CRISPR Detection Mechanism by Sizing Double‐Stranded λ DNA Reporter
Angewandte Chemie.
Source: ORCID
Added: December 2, 2022
2022 article
Recent Advances in Clustered Regularly Interspaced Short Palindromic Repeats-Based Biosensors for Point-of-Care Pathogen Detection
Mohammad, N., Katkam, S. S., & Wei, Q. (2022, July 18). CRISPR JOURNAL, Vol. 7.
MeSH headings : Biosensing Techniques; CRISPR-Cas Systems / genetics; Gene Editing / methods; Plants; Point-of-Care Systems
TL;DR:
This review highlights recent efforts in configuring CRISPR technology as an efficient diagnostic tool for pathogen detection, including the development of new signaling mechanisms, elimination of preamplification and sample pretreatment steps, and miniaturization ofCRISPR reactions on digital assay chips and lateral flow devices.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
9. Industry, Innovation and Infrastructure
(OpenAlex)
Sources: Web Of Science, NC State University Libraries, ORCID
Added: August 1, 2022
2021 article
Recent Advances in Aptamer-Based Biosensors for Global Health Applications
ANNUAL REVIEW OF BIOMEDICAL ENGINEERING, VOL 23, 2021, Vol. 23, pp. 433–459.
author keywords: aptamer recognition; biosensors; point-of-care diagnostics; global health; optical sensors; electrochemical sensors
MeSH headings : Aptamers, Nucleotide; Biosensing Techniques; Global Health; Proteins
TL;DR:
A description of general aptasensing principles is provided and examples of recent reports of diagnostics-related applications, including detection of proteins and small molecules, circulating cancer cells, whole-cell pathogens, extracellular vesicles, and tissue diagnostics are discussed.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, NC State University Libraries
Added: August 2, 2021
2020 journal article
Comparative Assessment of Growth and Morphological Responses Reveals Resilience of HeLa cells over Vero Cells on Exposure to Arsenic (III)
Asian Journal of Pharmaceutical and Health Sciences, 10(2). https://ajphs.com/article/2020/10/2/2291-2302
Source: ORCID
Added: September 22, 2024
Employment
Updated: August 16th, 2020 12:47
2019 - present
North Carolina State University Raleigh, North Carolina, US
Graduate Research Assistant
Chemical and Biomolecular Engineering
2019 - present
Bangladesh University of Engineering and Technology Dhaka, Dhaka District, BD
Assistant Professor (On Leave)
Chemical Engineering
2016 - 2019
Bangladesh University of Engineering and Technology Dhaka, Dhaka District, BD
Lecturer
Chemical Engineering
Education
Updated: September 17th, 2024 21:25
2019 - 2024
North Carolina State University Raleigh, US
Ph.D.
Chemical and Biomolecular Engineering
2016 - 2018
Bangladesh University of Engineering and Technology Dhaka, BD
M.Sc.
Chemical Engineering
2011 - 2016
Bangladesh University of Engineering and Technology Dhaka, BD
B.Sc.
Chemical Engineering
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