Nina Alexandra Moiseiwitsch

Works (7)

Updated: June 29th, 2024 05:02

2024 article

Clot-Targeted Nanogels for Dual-Delivery of AntithrombinIII and Tissue Plasminogen Activator to Mitigate Disseminated Intravascular Coagulation Complications

Sheridan, A., Nellenbach, K., Pandit, S., Byrnes, E., Hardy, G., Lutz, H., … Brown, A. C. (2024, June 5). ACS NANO, Vol. 6.

By: A. Sheridan n, K. Nellenbach n, S. Pandit n, E. Byrnes n, G. Hardy n, H. Lutz  n, N. Moiseiwitsch n, G. Scull n ...

author keywords: nanogel; fibrin; thrombosis; hemorrhage; fibrinolytic; anticoagulant
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Sources: Web Of Science, NC State University Libraries
Added: June 24, 2024

2024 journal article

Ultrasoft platelet-like particles stop bleeding in rodent and porcine models of trauma

Science Translational Medicine, 16(742).

By: K. Nellenbach n, E. Mihalko n, S. Nandi n, D. Koch n, J. Shetty *, L. Moretti *, J. Sollinger n, N. Moiseiwitsch n ...

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Sources: Web Of Science, NC State University Libraries, Crossref
Added: April 22, 2024

2023 journal article

Influence of Fibrinogen Concentrate on Neonatal Clot Structure When Administered Ex Vivo After Cardiopulmonary Bypass

Anesthesia & Analgesia, 137(3), 682–690.

By: N. Moiseiwitsch n, K. Nellenbach n, L. Downey *, D. Boorman *, A. Brown n  & N. Guzzetta *

TL;DR: It is suggested that FC is effective in restoring structural fibrin clot properties after CPB, and further studies after the administration of FC in vivo are needed to validate this hypothesis. (via Semantic Scholar)
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Sources: Web Of Science, NC State University Libraries, Crossref
Added: September 5, 2023

2022 journal article

COVID‐19 patient fibrinogen produces dense clots with altered polymerization kinetics, partially explained by increased sialic acid

Journal of Thrombosis and Haemostasis, 20(12), 2909–2920.

By: N. Moiseiwitsch n, N. Zwennes n, F. Szlam *, R. Sniecinski * & A. Brown n 

author keywords: coagulopathy; COVID-19; fibrinogen; sialic acid; thrombosis
MeSH headings : Humans; Fibrinogen / metabolism; Fibrin / chemistry; N-Acetylneuraminic Acid; COVID-19; Polymerization; Neuraminidase; SARS-CoV-2; Fibrinolysis; Thrombosis / metabolism; Hemostatics
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Sources: Web Of Science, NC State University Libraries, Crossref
Added: October 17, 2022

2021 article

Ex Vivo and In Vivo Evaluation of Fibrinogen Concentrate to Mitigate Post-Surgical Bleeding in Neonates

Moiseiwitsch, N., Nellenbach, K. A., Guzzetta, N. A., Brown, A. C., & Downey, L. (2021, November 23). BLOOD, Vol. 138.

By: N. Moiseiwitsch n, K. Nellenbach n, N. Guzzetta *, A. Brown n  & L. Downey *

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Added: September 6, 2022

2021 journal article

Fibrin‐specific <scp>poly(N‐isopropylacrylamide)</scp> nanogels for targeted delivery of tissue‐type plasminogen activator to treat thrombotic complications are well tolerated in vivo

Bioengineering & Translational Medicine, 7(2).

By: E. Mihalko n, K. Nellenbach n, M. Krishnakumar n, N. Moiseiwitsch n, J. Sollinger n, B. Cooley *, A. Brown n 

author keywords: disseminated intravascular coagulation; fibrin; nanogels; pNIPAM; targeted delivery; thrombosis; tissue plasminogen activator
TL;DR: The therapeutic efficacy of targeted fibrin‐specific nanogel (FSN) design for targeted delivery of tPA to treat thrombotic complications is demonstrated and key translational parameters for tPA‐FSN therapeutics are evaluated, including optimal tPA •FSN dosage in a DIC rodent model and safety of intravenous tPA•FSN therapies. (via Semantic Scholar)
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3. Good Health and Well-being (Web of Science; OpenAlex)
Sources: Web Of Science, NC State University Libraries, Crossref
Added: December 20, 2021

2021 journal article

Neonatal coagulopathies: A review of established and emerging treatments

Experimental Biology and Medicine, 246(12), 1447–1457.

By: N. Moiseiwitsch n & A. Brown n 

author keywords: Neonatal; coagulopathy; developmental hemostasis; transfusion
MeSH headings : Animals; Blood Coagulation Disorders / etiology; Blood Coagulation Disorders / therapy; Hemorrhage / etiology; Hemorrhage / therapy; Hemostasis / physiology; Humans; Infant, Newborn; Infant, Newborn, Diseases / etiology; Infant, Newborn, Diseases / therapy
TL;DR: This mini-review examines the current understanding of neonatal hemostatic balance and treatment of Neonatal coagulopathies, with particular emphasis on emerging treatment methods and areas in need of further investigative efforts. (via Semantic Scholar)
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Sources: Web Of Science, Crossref, NC State University Libraries
Added: July 12, 2021

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