@article{kaveti_jakus_chen_jain_kennedy_caso_mishra_sharma_uzunoglu_han_et al._2024, title={Water-powered, electronics-free dressings that electrically stimulate wounds for rapid wound closure}, volume={10}, ISSN={["2375-2548"]}, url={http://dx.doi.org/10.1126/sciadv.ado7538}, DOI={10.1126/sciadv.ado7538}, abstractNote={Chronic wounds affect ~2% of the U.S. population and increase risks of amputation and mortality. Unfortunately, treatments for such wounds are often expensive, complex, and only moderately effective. Electrotherapy represents a cost-effective treatment; however, its reliance on bulky equipment limits its clinical use. Here, we introduce water-powered, electronics-free dressings (WPEDs) that offer a unique solution to this issue. The WPED performs even under harsh conditions—situations wherein many present treatments fail. It uses a flexible, biocompatible magnesium-silver/silver chloride battery and a pair of stimulation electrodes; upon the addition of water, the battery creates a radial electric field. Experiments in diabetic mice confirm the WPED’s ability to accelerate wound closure and promote healing by increasing epidermal thickness, modulating inflammation, and promoting angiogenesis. Across preclinical wound models, the WPED-treated group heals faster than the control with wound closure rates comparable to treatments requiring expensive biologics and/or complex electronics. The results demonstrate the WPED’s potential as an effective and more practical wound treatment dressing.}, number={32}, journal={SCIENCE ADVANCES}, author={Kaveti, Rajaram and Jakus, Margaret A. and Chen, Henry and Jain, Bhavya and Kennedy, Darragh G. and Caso, Elizabeth A. and Mishra, Navya and Sharma, Nivesh and Uzunoglu, Baha Erim and Han, Won Bae and et al.}, year={2024}, month={Aug} }
 @article{garland_song_ma_kim_vazquez-guardado_hashkavayi_ganeshan_sharma_ryu_lee_et al._2023, title={A Miniaturized, Battery-Free, Wireless Wound Monitor That Predicts Wound Closure Rate Early}, volume={7}, ISSN={["2192-2659"]}, url={http://dx.doi.org/10.1002/adhm.202301280}, DOI={10.1002/adhm.202301280}, abstractNote={AbstractDiabetic foot ulcers are chronic wounds that affect millions and increase the risk of amputation and mortality, highlighting the critical need for their early detection. Recent demonstrations of wearable sensors enable real‐time wound assessment, but they rely on bulky electronics, making them difficult to interface with wounds. Herein, a miniaturized, wireless, battery‐free wound monitor that measures lactate in real‐time and seamlessly integrates with bandages for conformal attachment to the wound bed is introduced. Lactate is selected due to its multifaceted role in initiating healing. Studies in healthy and diabetic mice reveal distinct lactate profiles for normal and impaired healing wounds. A mathematical model based on the sensor data predicts wound closure rate within the first 3 days post‐injury with ≈76% accuracy, which increases to ≈83% when pH is included. These studies underscore the significance of monitoring biomarkers during the inflammation phase, which can offer several benefits, including short‐term use of wound monitors and their easy removal, resulting in lower risks of injury and infection at the wound site. Improvements in prediction accuracy can be achieved by designing mathematical models that build on multiple wound parameters such as pro‐inflammatory and metabolic markers. Achieving this goal will require designing multi‐analyte wound monitors.}, number={28}, journal={ADVANCED HEALTHCARE MATERIALS}, publisher={Wiley}, author={Garland, Nate T. and Song, Joseph W. and Ma, Tengfei and Kim, Yong Jae and Vazquez-Guardado, Abraham and Hashkavayi, Ayemeh Bagheri and Ganeshan, Sankalp Koduvayur and Sharma, Nivesh and Ryu, Hanjun and Lee, Min-Kyu and et al.}, year={2023}, month={Jul} }
 @article{boologam_krishnan_palaniswamy_kumar_bhowmik_sharma_vaish_chatterjee_2022, title={On the Design and Development of Planar Monopole Antenna for Bone Crack/Void Detection}, url={http://dx.doi.org/10.1155/2022/4663488}, DOI={10.1155/2022/4663488}, abstractNote={In this study, the design of a compact narrowband monopole antenna for bone crack detection is presented. The proposed antenna consists of a modified hexagon-shaped radiator with six triangular slits integrated on its bottom periphery, a rectangular-shaped ground plane, and a microstrip feed line of 50 Ω. The antenna is fabricated on the FR-4 substrate with a thickness of 1.6 mm, an overall size of 32 mm × 30 mm, and electrical dimensions of 0.13λ0 × 0.122λ0, where λ0 is the free space wavelength at 2.45 GHz. The resonant frequency of the designed antenna is 2.45 GHz. The antenna offers a gain of 1.68 dB and an efficiency of 85.3%. The presence of a crack in the bone is detected by observing the shift in the peak resonating frequency of the antenna. This method can detect bone fractures in a noninvasive manner. The human arm model is constructed, and the effect of bone cracks of different lengths on the resonating frequency is investigated. The pig bone and tissues are used to validate the simulated results. The simulated results are in agreement with the measured outcomes. Also, the specific absorption rate (SAR) of the antenna is calculated and found to be less than 0.57 W/kg. The designed monopole antenna has several advantages, including a small footprint, straightforward design, low cost, and easy integration with other devices. The proposed method is suitable for primary-level bone crack diagnosis.}, journal={International Journal of Antennas and Propagation}, author={Boologam, Ananda Venkatesan and Krishnan, Kalimuthu and PALANISWAMY, SANDEEP KUMAR and Kumar, Sachin and Bhowmik, Shreya and Sharma, Nivesh and Vaish, Deepesh and Chatterjee, Sourish}, year={2022}, month={May} }