Works (2)
Updated: July 17th, 2023 21:17
2018 journal article
Cadmium disrupts signaling of the hypoxia-inducible (HIF) and transforming growth factor (TGF-beta) pathways in placental JEG-3 trophoblast cells via reactive oxygen species
TOXICOLOGY AND APPLIED PHARMACOLOGY, 342, 108–115.
author keywords: Reactive oxygen species; Hypoxia; Placentation; Growth factor; Gene expression; Cadmium
MeSH headings : Cadmium / toxicity; Cell Line, Tumor; Dose-Response Relationship, Drug; Female; Humans; Hypoxia-Inducible Factor 1, alpha Subunit / antagonists & inhibitors; Hypoxia-Inducible Factor 1, alpha Subunit / metabolism; Placenta / cytology; Placenta / drug effects; Placenta / metabolism; Pregnancy; Reactive Oxygen Species / metabolism; Signal Transduction / drug effects; Signal Transduction / physiology; Transforming Growth Factor beta / antagonists & inhibitors; Transforming Growth Factor beta / metabolism; Trophoblasts / drug effects; Trophoblasts / metabolism
TL;DR:
Treatment of placental trophoblast cells with Cd results in increased production of ROSs that disrupt placentation pathways involved in disease pathogenesis, and co‐occurrence of Cd with other toxic metals, particularly arsenic, may induce detrimental health effects that are currently underestimated when analyzed as single metals.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
5. Gender Equality
(Web of Science)
Sources: Web Of Science, ORCID, NC State University Libraries
Added: August 6, 2018
2015 journal article
Toxicological responses of environmental mixtures: Environmental metal mixtures display synergistic induction of metal-responsive and oxidative stress genes in placental cells
TOXICOLOGY AND APPLIED PHARMACOLOGY, 289(3), 534–541.
author keywords: Toxicogenomics; Biomarkers; Real-world mixtures; Gene expression; Synergism; mRNA
MeSH headings : Arsenic / toxicity; Cadmium / toxicity; Cell Line, Tumor; China; Dose-Response Relationship, Drug; Female; Heavy Metal Poisoning; Humans; Metallothionein / metabolism; Metals, Heavy / toxicity; Oxidative Stress / drug effects; Oxidative Stress / genetics; Placenta / drug effects; Placenta / metabolism; Poisoning; Pregnancy; Water Pollutants, Chemical / toxicity
TL;DR:
It is demonstrated that metal mixtures increase the expression of gene biomarkers in placental JEG-3 cells in a synergistic manner, suggesting that toxic metals that co-occur may induce detrimental health effects that are currently underestimated when analyzed as single metals.
(via Semantic Scholar)
open access via europepmc.org (repository)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, ORCID, NC State University Libraries
Added: August 6, 2018
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