Piyum Khatibi

Works (6)

Updated: July 5th, 2023 15:36

2019 journal article

Lignocellulose solubilization and conversion by extremely thermophilic Caldicellulosiruptor bescii improves by maintaining metabolic activity

BIOTECHNOLOGY AND BIOENGINEERING, 116(8), 1901–1908.

By: C. Straub n, P. Khatibi n, J. Otten n, M. Adams * & R. Kelly n 

author keywords: biofuels; bioreactor; Caldicellulosiruptor bescii; lignocellulose; switchgrass
MeSH headings : Biofuels / microbiology; Bioreactors; Caldicellulosiruptor; Fermentation; Firmicutes / growth & development; Firmicutes / metabolism; Lignin / metabolism; Panicum / metabolism; Solubility
TL;DR: The extreme thermophile Caldicellulosiruptor bescii solubilized carbohydrate conversion to fermentation products increased from 40% in batch to over 80% in the purged system, an improvement attributed to maintaining the bioreactor culture in a metabolically active state. (via Semantic Scholar)
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Sources: Web Of Science, NC State University Libraries
Added: August 19, 2019

2019 journal article

Quantitative fermentation of unpretreated transgenic poplar by Caldicellulosiruptor bescii

NATURE COMMUNICATIONS, 10(1).

By: C. Straub n, P. Khatibi n, J. Wang n , J. Conway n, A. Williams-Rhaesa *, I. Peszlen n , V. Chiang n, M. Adams *, R. Kelly n 

Contributors: C. Straub n, P. Khatibi n, J. Wang n , J. Conway n, A. Williams-Rhaesa *, I. Peszlen n , V. Chiang n, M. Adams *, R. Kelly n 

MeSH headings : Biomass; Cellulose / metabolism; Clostridiales / genetics; Clostridiales / metabolism; Ethanol / metabolism; Fermentation; Industrial Microbiology; Lignin / metabolism; Metabolic Engineering; Plants, Genetically Modified / chemistry; Plants, Genetically Modified / genetics; Plants, Genetically Modified / metabolism; Polysaccharides / metabolism; Populus / chemistry; Populus / genetics; Populus / metabolism
TL;DR: The authors pair transgenic lignin modified poplar lines with engineered Caldicellusiruptor bescii to achieve biomass solubilization and ethanol conversion without pretreatment and the nearly quantitative microbial conversion of the carbohydrate content of unpretreated transgen lignocellulosic biomass bodes well for full utilization of renewable biomass feedstocks. (via Semantic Scholar)
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Sources: Web Of Science, ORCID, NC State University Libraries
Added: August 26, 2019

2017 journal article

Bioavailability of Carbohydrate Content in Natural and Transgenic Switchgrasses for the Extreme Thermophile Caldicellulosiruptor bescii

APPLIED AND ENVIRONMENTAL MICROBIOLOGY, 83(17).

By: J. Zurawski n, P. Khatibi n, H. Akinosho *, C. Straub n, S. Compton n, J. Conway n, L. Lee n, A. Ragauskas * ...

author keywords: Caldicellulosiruptor; switchgrass; lignocellulose deconstruction and conversion; extreme thermophiles; lignocellulose
MeSH headings : Biomass; Fermentation; Gram-Positive Bacteria / genetics; Gram-Positive Bacteria / metabolism; Hot Temperature; Lignin / chemistry; Lignin / metabolism; Panicum / chemistry; Panicum / genetics; Panicum / metabolism; Panicum / microbiology; Plants, Genetically Modified / chemistry; Plants, Genetically Modified / genetics; Plants, Genetically Modified / metabolism; Plants, Genetically Modified / microbiology; Polysaccharides / chemistry; Polysaccharides / metabolism
TL;DR: While C. bescii could significantly solubilize the transgenic switchgrass lines and natural variant tested here, additional or alternative strategies (physical, chemical, enzymatic, and/or genetic) are needed to eliminate recalcitrance. (via Semantic Scholar)
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Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018

2017 journal article

Genome Stability in Engineered Strains of the Extremely Thermophilic Lignocellulose-Degrading Bacterium Caldicellulosiruptor bescii

APPLIED AND ENVIRONMENTAL MICROBIOLOGY, 83(14).

By: A. Williams-Rhaesa *, F. Poole*, J. Dinsmore*, G. Lipscomb*, G. Rubinstein*, I. Scott*, J. Conway n, L. Lee n ...

author keywords: Southern blotting; genome sequencing; insertion elements; kanamycin resistance
MeSH headings : Bacterial Proteins / genetics; Bacterial Proteins / metabolism; Genetic Engineering; Genome, Bacterial; Genomic Instability; Gram-Positive Bacteria / genetics; Gram-Positive Bacteria / metabolism; Hot Temperature; Lignin / metabolism
TL;DR: It is shown that strains derived from the genetic background containing a random deletion in uracil biosynthesis genes (pyrFA) have a dramatic increase in the number of single nucleotide polymorphisms, insertions/deletions, and ISCbe4 insertion elements in their genomes compared to the wild type. (via Semantic Scholar)
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Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018

2017 journal article

Impact of growth mode, phase, and rate on the metabolic state of the extremely thermophilic archaeon Pyrococcus furiosus

BIOTECHNOLOGY AND BIOENGINEERING, 114(12), 2947–2954.

By: P. Khatibi n, C. Chou n, A. Loder n, J. Zurawski n, M. Adams * & R. Kelly n 

author keywords: continuous culture; growth phase; growth rate; hyperthermophiles; Pyrococcus furiosus; transcriptome
MeSH headings : Archaeal Proteins / metabolism; Batch Cell Culture Techniques / methods; Cell Proliferation / physiology; Energy Metabolism / physiology; Pyrococcus furiosus / growth & development; Pyrococcus furiosus / metabolism; Transcriptome / physiology
TL;DR: The results here suggest that cellular processes involved in carbon and electron flux in P. furiosus were significantly impacted by growth mode, phase and rate, factors that need to be taken into account when developing successful metabolic engineering strategies. (via Semantic Scholar)
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Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018

2016 journal article

Differential detection of a surrogate biological threat agent (Bacillus globigii) with a portable surface plasmon resonance biosensor

Biosensors & Bioelectronics, 78, 160–166.

By: B. Adducci, H. Gruszewski, P. Khatibi & D. Schmale

Source: NC State University Libraries
Added: August 6, 2018

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