Preston Gourville

College of Sciences

Works (1)

Updated: July 5th, 2023 15:21

2019 journal article

Aza-Amino Acids Disrupt -Sheet Secondary Structures

MOLECULES, 24(10).

By: M. McMechen n, E. Willis n, P. Gourville n & C. Proulx n 

author keywords: peptidomimetics; azapeptides; aza-amino acids; -hairpin; -sheet
MeSH headings : Amino Acid Sequence; Amino Acids / chemistry; Aza Compounds / chemistry; Aza Compounds / pharmacology; Hydrogen Bonding; Molecular Structure; Peptides / chemical synthesis; Peptides / chemistry; Protein Folding; Protein Structure, Secondary / drug effects; Proteins / chemistry; Solid-Phase Synthesis Techniques
TL;DR: The effect of a single aza-amino acid incorporation located in the upper β-strand at a hydrogen-bonded (HB) site of a β-hairpin model peptide (H-Arg-Tyr-Val-Glu- Val-d-Pro-Gly-Orn-Lys-Ile-Leu-Gln-NH2) is reported. (via Semantic Scholar)
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Sources: Web Of Science, ORCID, NC State University Libraries
Added: July 1, 2019

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