@article{varghese_zhao_chen_hu_2024, title={Chitosan-nanoclay embolic material for catheter-directed arterial embolization}, volume={1}, ISSN={["1552-4965"]}, url={https://doi.org/10.1002/jbm.a.37670}, DOI={10.1002/jbm.a.37670}, abstractNote={Abstract}, journal={JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART A}, author={Varghese, P. J. George and Zhao, Keren and Chen, Peng and Hu, Jingjie}, year={2024}, month={Jan} }
 @article{zhao_varghese_chen_hu_2024, title={Developing a transcatheter injectable nanoclay- alginate gel for minimally invasive procedures}, volume={152}, ISSN={["1878-0180"]}, url={https://doi.org/10.1016/j.jmbbm.2024.106448}, DOI={10.1016/j.jmbbm.2024.106448}, abstractNote={Shear-thinning materials have held considerable promise as embolic agents due to their capability of transition between solid and liquid state. In this study, a laponite nanoclay (NC)/alginate gel embolic agent was developed, characterized, and studied for transcatheter based minimally invasive procedures. Both NC and alginate are biocompatible and FDA-approved. Due to electrostatic interactions, the NC/alginate gels exhibit shear-thinning properties that are desirable for transcatheter delivery. The unique shear-thinning nature of the NC/alginate gel allows it to function as a fluid-like substance during transcatheter delivery and as a solid-like embolic agent once deployed. To ensure optimal performance and safety in clinical applications, the rheological characteristics were thoroughly investigated to optimize the mechanical properties of the NC/alginate gel, including storage modulus, yield stress/strain, and thixotropy. To improve physicians' experience and enhance the predictability of gel delivery, a combination of experimental and theoretical approaches was used to assess the injection force required for successful delivery of the gel through clinically employed catheters. Overall, NC/alginate gel exhibited excellent stability and tunable injectability by optimizing the composition of each component. These findings highlight the gel's potential as a robust embolic agent for a wide range of minimally invasive procedures.}, journal={JOURNAL OF THE MECHANICAL BEHAVIOR OF BIOMEDICAL MATERIALS}, author={Zhao, Keren and Varghese, P. J. George and Chen, Peng and Hu, Jingjie}, year={2024}, month={Apr} }