Works (5)

Updated: July 10th, 2023 21:17

2015 journal article

Coordinated regulation of Nrf2 and histone H3 serine 10 phosphorylation in arsenite-activated transcription of the human heme oxygenase-1 gene


By: P. Ray n, B. Huang n & Y. Tsuji n

author keywords: Nrf2; Histone; Epigenetic; Arsenic; HO-1; Antioxidant response element
MeSH headings : Animals; Antioxidant Response Elements / genetics; Arsenites / pharmacology; Gene Expression Regulation, Enzymologic; Heme Oxygenase-1 / biosynthesis; Heme Oxygenase-1 / genetics; Heme Oxygenase-1 / metabolism; Histones / genetics; Histones / metabolism; Humans; Keratinocytes / metabolism; Mice; NF-E2-Related Factor 2 / genetics; NF-E2-Related Factor 2 / metabolism; Oxidative Stress / genetics; Phosphorylation; Promoter Regions, Genetic; Protein Binding; Signal Transduction; Transcriptional Activation / drug effects; Transcriptional Activation / genetics
TL;DR: It is proposed that Nrf2 may influence H3S10 phosphorylation at the HO-1 ARE and additional promoter regions, which highlights the complex interplay between NRF2 and H 3S10osphorylation in arsenite-activatedHO-1 transcription. (via Semantic Scholar)
Source: Web Of Science
Added: August 6, 2018

2013 journal article

Role of AMP-Activated Protein Kinase in Ferritin H Gene Expression by Resveratrol in Human T Cells

BIOCHEMISTRY, 52(30), 5075–5083.

By: K. Iwasaki*, P. Ray n, B. Huang n, K. Sakamoto n, T. Kobayashi* & Y. Tsuji n

MeSH headings : AMP-Activated Protein Kinases / antagonists & inhibitors; AMP-Activated Protein Kinases / chemistry; AMP-Activated Protein Kinases / genetics; AMP-Activated Protein Kinases / metabolism; Antioxidants / chemistry; Antioxidants / pharmacology; Apoferritins / genetics; Apoferritins / metabolism; Enzyme Activation / drug effects; Gene Expression Regulation / drug effects; Glycogen Synthase Kinase 3 / antagonists & inhibitors; Glycogen Synthase Kinase 3 / genetics; Glycogen Synthase Kinase 3 / metabolism; Glycogen Synthase Kinase 3 beta; Humans; Jurkat Cells; K562 Cells; Leukocytes, Mononuclear / drug effects; Leukocytes, Mononuclear / metabolism; NF-E2-Related Factor 2 / metabolism; Oxidative Stress / drug effects; Phosphorylation / drug effects; Protein Processing, Post-Translational / drug effects; RNA Interference; Response Elements / drug effects; Resveratrol; Serine / metabolism; Stilbenes / antagonists & inhibitors; Stilbenes / pharmacology; T-Lymphocytes / drug effects; T-Lymphocytes / metabolism
TL;DR: It is found that AMP-activated protein kinase (AMPK) plays a key role in the activation of nuclear factor E2-related factor (Nrf2) and subsequent ARE-dependent ferritin H gene transcription by resveratrol. (via Semantic Scholar)
Source: Web Of Science
Added: August 6, 2018

2013 journal article

Transcriptional regulation of the human ferritin gene by coordinated regulation of Nrf2 and protein arginine methyltransferases PRMT1 and PRMT4

FASEB JOURNAL, 27(9), 3763–3774.

By: B. Huang n, P. Ray n, K. Iwasaki* & Y. Tsuji n

author keywords: arsenic; histone methylation; antioxidant; oxidative stress
MeSH headings : Antioxidants / metabolism; Arsenic / toxicity; Cell Line; Cells, Cultured; Ferritins / genetics; Fibroblasts / cytology; Fibroblasts / metabolism; Histones / metabolism; Humans; Keratinocytes / cytology; Keratinocytes / metabolism; Methylation; NF-E2-Related Factor 2 / genetics; NF-E2-Related Factor 2 / metabolism; Oxidative Stress / drug effects; Oxidative Stress / genetics; Protein-Arginine N-Methyltransferases / genetics; Protein-Arginine N-Methyltransferases / metabolism; Repressor Proteins / genetics; Repressor Proteins / metabolism; Transcription, Genetic / drug effects; Transcription, Genetic / genetics
TL;DR: To test the hypothesis that histone H4R3 and H3R17 methylation regulates ferritin transcription, PRMT1 and PRMT4 regulate the ARE and cellular antioxidant response to arsenic, and focused microarray characterized several oxidative stress response genes are subject toPRMT1 orPRMT4 regulation. (via Semantic Scholar)
Source: Web Of Science
Added: August 6, 2018

2012 review

Reactive oxygen species (ROS) homeostasis and redox regulation in cellular signaling

[Review of ]. CELLULAR SIGNALLING, 24(5), 981–990.

By: P. Ray n, B. Huang n & Y. Tsuji n

author keywords: Reactive oxygen species; MAPK; Shc; Nrf2; ATM; Iron
MeSH headings : Amino Acid Sequence; Animals; Gene Expression Regulation; Homeostasis; Humans; Intracellular Signaling Peptides and Proteins / metabolism; Intracellular Signaling Peptides and Proteins / physiology; Molecular Sequence Data; Oxidation-Reduction; Oxidative Stress; Reactive Oxygen Species / metabolism; Signal Transduction
TL;DR: This review focuses on the molecular mechanisms through which ROS directly interact with critical signaling molecules to initiate signaling in a broad variety of cellular processes, such as proliferation and survival, ROS homeostasis and antioxidant gene regulation, mitochondrial oxidative stress, apoptosis, and aging. (via Semantic Scholar)
Source: Web Of Science
Added: August 6, 2018

2008 journal article

Role and regulation of ferritin H in rotenone-mediated mitochondrial oxidative stress


By: E. MacKenzie n, P. Ray n & Y. Tsuji n

author keywords: ferritin; rotenone; mitochondria; iron; oxidative stress; free radicals
MeSH headings : Animals; Antioxidants / metabolism; Apoferritins / chemistry; Cell Line, Tumor; Gene Expression Regulation; Humans; Mice; Mitochondria / metabolism; Models, Biological; NF-E2-Related Factor 2 / metabolism; NIH 3T3 Cells; Oxidative Stress; Proto-Oncogene Proteins / metabolism; Proto-Oncogene Proteins c-jun; Rotenone / pharmacology; Uncoupling Agents / pharmacology
TL;DR: Results suggest that ferritin H transcription is activated by rotenone via an oxidative stress-mediated pathway leading to ARE activation and may be critically important to protect cells from mitochondrial dysfunction and oxidative stress. (via Semantic Scholar)
Source: Web Of Science
Added: August 6, 2018

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