Works (173)

Updated: May 1st, 2024 05:02

2024 review

Biomimetic Scaffolds-A Novel Approach to Three Dimensional Cell Culture Techniques for Potential Implementation in Tissue Engineering

[Review of ]. NANOMATERIALS, 14(6).

By: T. Gornicki*, J. Lambrinow*, A. Golkar-Narenji n, K. Data*, D. Domagala*, J. Niebora*, M. Farzaneh*, P. Mozdziak n ...

author keywords: biomimetic scaffolds; 3D bioprinting; biologically derived materials; 4D materials
TL;DR: Increasing amounts of data provide evidence of vast potential of biomimetic scaffolds usage in tissue engineering and personalized medicine, with the main area of potential application being the regeneration of skin and musculoskeletal systems. (via Semantic Scholar)
Sources: ORCID, Web Of Science, NC State University Libraries
Added: March 22, 2024

2024 review

Cardiac progenitor cell therapy: mechanisms of action

[Review of ]. CELL AND BIOSCIENCE, 14(1).

By: R. Bryl*, M. Kulus*, A. Bryja*, D. Domagala*, P. Mozdziak n, P. Antosik*, D. Bukowska*, M. Zabel*, P. Dziegiel*, B. Kempisty n

author keywords: Cardiac regeneration; Adult cardiac progenitor cells; Exosomes; Non-coding RNAs
UN Sustainable Development Goal Categories
3. Good Health and Well-being (OpenAlex)
Sources: Web Of Science, NC State University Libraries
Added: April 1, 2024

2024 review

Cellular, Molecular and Clinical Aspects of Aortic Aneurysm-Vascular Physiology and Pathophysiology

[Review of ]. CELLS, 13(3).

author keywords: inflammation; vessel; VSMCs; ECM
TL;DR: The key mechanisms of initiating and promoting AAA are considered to achieve better preventative and therapeutic outcomes and to achieve better preventative and therapeutic outcomes. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (OpenAlex)
Sources: ORCID, Web Of Science, NC State University Libraries
Added: February 6, 2024

2024 journal article

New Gene Markers Regulating the Process of Vascularization in Pig Preovulatory Oocytes during Growth and Maturation

JOURNAL OF BIOLOGICAL REGULATORS AND HOMEOSTATIC AGENTS, 38(4), 2807–2824.

By: B. Borowiec, W. Kranc, M. Kulus, P. Sujka-Kordowska, A. Konwerska, P. Celichowski, M. Jozkowiak, J. Kulus ...

author keywords: cumulus-oocyte complexes; cumulus cells; gene ontology; ovary; sus scrofa; VEGFA
Sources: Web Of Science, NC State University Libraries
Added: April 29, 2024

2024 article

Phenotypic Transitions the Processes Involved in Regulation of Growth and Proangiogenic Properties of Stem Cells, Cancer Stem Cells and Circulating Tumor Cells

Kulus, M., Farzaneh, M., Bryja, A., Zehtabi, M., Azizidoost, S., Dari, M. A. G., … Antosik, P. (2024, February 19). STEM CELL REVIEWS AND REPORTS, Vol. 2.

By: M. Kulus*, M. Farzaneh*, A. Bryja*, M. Zehtabi*, S. Azizidoost*, M. Dari*, A. Golcar-Narenji n, H. Ziemak* ...

author keywords: Epithelial-mesenchymal Transition (EMT); Mesenchymal-epithelial Transition (MET); Circulating Tumor cell (CTC); Cancer stem Cells
TL;DR: While EMT is necessary for metastasis, MET is required for CTCs to establish a secondary site, and a thorough understanding of the processes that govern the balance between EMT and MET in malignancy is crucial. (via Semantic Scholar)
Sources: Web Of Science, NC State University Libraries
Added: March 11, 2024

2023 journal article

Apoptosis Related Human Wharton's Jelly-Derived Stem Cells Differentiation into Osteoblasts, Chondrocytes, Adipocytes and Neural-like Cells-Complete Transcriptomic Assays

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, 24(12).

author keywords: Wharton's jelly; mesenchymal stem cells; RNAseq; MSC; differentiation; apoptosis
TL;DR: In this study, cells were isolated from Wharton’s jelly of umbilical cords obtained from healthy full-term deliveries, cultivated in vitro, and differentiated towards osteogenic, chondrogenic, adipogenic and neurogenic lineages, providing an insight into the molecular mechanisms involved in the long-term culture in vitro and four-lineage differentiation of WJ-MSCs. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Sources: ORCID, Web Of Science, NC State University Libraries
Added: June 13, 2023

2023 review

Bioreactors, scaffolds and microcarriers and in vitro meat production-current obstacles and potential solutions

[Review of ]. FRONTIERS IN NUTRITION, 10.

By: M. Kulus*, M. Jankowski*, W. Kranc*, A. Narenji n, M. Farzaneh*, P. Dziegiel*, M. Zabel*, P. Antosik* ...

author keywords: bioreactor; cultured meat; scaffold; microcarriers; in vitro culture
TL;DR: This review summarizes the most current knowledge regarding the history of cultured meat, the currently used cell sources and methods used for the purpose of in vitro meat production, with particular focus on the role of bioreactors, scaffolds and microcarriers in overcoming the current obstacles. (via Semantic Scholar)
Sources: Web Of Science, NC State University Libraries
Added: October 10, 2023

2023 review

Decellularization of Dense Regular Connective Tissue-Cellular and Molecular Modification with Applications in Regenerative Medicine

[Review of ]. CELLS, 12(18).

By: K. Data*, M. Kulus*, H. Ziemak*, M. Chwarzynski*, H. Piotrowska-Kempisty*, D. Bukowska*, P. Antosik*, P. Mozdziak n, B. Kempisty n

author keywords: tendon; ligament; bioscaffold; extracellular matrix
TL;DR: The wide spectrum of decellularization makes it important to understand the key aspects of bioscaffolds relative to their potential use in tissue regeneration, as well as provide a valuable source of crucial information. (via Semantic Scholar)
Sources: ORCID, Web Of Science, NC State University Libraries
Added: September 21, 2023

2023 review

Diagnostic Test Accuracy of Artificial Intelligence in Detecting Periapical Periodontitis on Two-Dimensional Radiographs: A Retrospective Study and Literature Review

[Review of ]. MEDICINA-LITHUANIA, 59(4).

By: J. Issa*, M. Jaber*, I. Rifai*, P. Mozdziak n, B. Kempisty n & M. Dyszkiewicz-Konwinska*

author keywords: artificial intelligence (AI); periapical periodontitis; diagnosis; two-dimensional radiographs; diagnostic test accuracy; automatic detection
MeSH headings : Humans; Retrospective Studies; Artificial Intelligence; Cone-Beam Computed Tomography; Periapical Periodontitis / diagnostic imaging; Periapical Periodontitis / pathology; Diagnostic Tests, Routine
TL;DR: Dicionocat (Diagnocat Ltd., San Francisco, CA, USA) showed an optimum accuracy for detecting periapical periodontitis on periAPical radiographs, but more research is needed to assess the diagnostic accuracy of artificial intelligence-based algorithms in dentistry. (via Semantic Scholar)
Sources: ORCID, Web Of Science, NC State University Libraries
Added: April 20, 2023

2023 review

Endocrine Disrupting Chemicals in Polycystic Ovary Syndrome: The Relevant Role of the Theca and Granulosa Cells in the Pathogenesis of the Ovarian Dysfunction

[Review of ]. CELLS, 12(1).

By: M. Jozkowiak*, H. Piotrowska-Kempisty*, D. Kobylarek*, N. Gorska*, P. Mozdziak n, B. Kempisty n, D. Rachon*, R. Spaczynski

author keywords: polycystic ovary syndrome; granulosa cells; theca cells; endocrine disrupting chemicals
MeSH headings : Female; Humans; Polycystic Ovary Syndrome; Endocrine Disruptors / toxicity; Granulosa Cells / pathology
TL;DR: The recent knowledge on PCOS pathophysiology, the role of granulosa and theca cells in PCos pathogenesis, and the evidence linking exposure to EDCs with reproductive disorders such as PCOS are reviewed. (via Semantic Scholar)
UN Sustainable Development Goal Categories
5. Gender Equality (Web of Science)
Sources: Web Of Science, NC State University Libraries, ORCID
Added: January 5, 2023

2023 journal article

Expression Profile of New Marker Genes Involved in Differentiation of Human Wharton's Jelly-Derived Mesenchymal Stem Cells into Chondrocytes, Osteoblasts, Adipocytes and Neural-like Cells

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, 24(16).

author keywords: Wharton's jelly; mesenchymal stem cells; RNA-seq; MSC; differentiation
TL;DR: Insight is provided into the transcriptomic changes occurring during the differentiation of WJ-MSCs and enables the identification of novel markers involved in this process, which may serve as a reference for further research exploring the role of these genes in physiology of Wj- MSCs and in regenerative medicine. (via Semantic Scholar)
Sources: ORCID, Web Of Science, NC State University Libraries
Added: August 23, 2023

2023 journal article

Expression of genes regulating cell division in porcine follicular granulosa cells

CELL DIVISION, 18(1).

By: J. Kulus*, W. Kranc*, M. Kulus*, P. Dziegiel*, D. Bukowska*, P. Mozdziak n, B. Kempisty*, P. Antosik*

author keywords: Follicular granulosa cells; Cellular signaling; Cytoskeleton organization; Cell cycle; Gene expression profile; Transcriptomics
TL;DR: The expression profile of selected genes brings new insight into regulation of physiological processes in porcine follicular granulosa cells during primary in vitro culture. (via Semantic Scholar)
Sources: Web Of Science, NC State University Libraries
Added: August 21, 2023

2023 article

In vitro culture of reptile PGCS to preserve endangered species

Golkar-Narenji, A., Dziegiel, P., Kempisty, B., Petitte, J., Mozdziak, P. E., & Bryja, A. (2023, May 13). CELL BIOLOGY INTERNATIONAL, Vol. 5.

By: A. Golkar-Narenji n, P. Dziegiel*, B. Kempisty n, J. Petitte n, P. Mozdziak n & A. Bryja*

author keywords: avian; development; embryo; mammals; primordial germ cells; reptiles
MeSH headings : Animals; Endangered Species; Animals, Genetically Modified; Germ Cells; Cell Differentiation; Reptiles; Mammals
TL;DR: It is proposed that a discussion on similarities between reptilian PGCs development with avian and mammalian species helps to find clues for studies of Reptilian P GCs development details and finding an efficient protocol for in vitro culture of reptilian PG. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Sources: Web Of Science, NC State University Libraries
Added: May 30, 2023

2023 journal article

Intravenous Transplantation of Adipose-Derived Mesenchymal Stem Cells Promoted The Production of Dopaminergic Neurons and Improved Spatial Memory in A Rat Model of Parkinson's Disease

CELL JOURNAL, 25(5), 317–326.

By: H. Hamedi*, S. Ghorbanian*, L. Mirzaeian*, K. Abrari*, P. Mozdziak* & M. Ghorbanian*

author keywords: Dopaminergic Neurons; Mesenchymal Stem Cells; Parkinson's Disease; 6-Hydroxydopamine
TL;DR: Assessment of the impact of intravenous infusion of adipose-derived mesenchymal stem cells (AD-MSCs) on memory disorder in Parkinsonian rats suggests that AD- MSCs treatment for Parkinson’s could decrease the density of astrocytes and promote thedensity of TH-positive neurons. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Source: Web Of Science
Added: July 24, 2023

2023 journal article

Intravenous transplantation of adipose-derived mesenchymal stem cells promoted the production of dopaminergic neurons and improved spatial memory in a rat model of Parkinson’s disease

Cell Journal (Yakhteh). https://www.celljournal.org/article_701450.html

Contributors: . mozdziak

Source: ORCID
Added: February 22, 2023

2023 journal article

New Gene Markers of Exosomal Regulation Are Involved in Porcine Granulosa Cell Adhesion, Migration, and Proliferation

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, 24(14).

By: J. Kulus*, W. Kranc*, M. Kulus*, D. Bukowska*, H. Piotrowska-Kempisty*, P. Mozdziak n, B. Kempisty n, P. Antosik*

author keywords: porcine granulosa cells; cellular signaling; extracellular vesicles; cell adhesion; cell migration and proliferation; transcriptomics; extracellular matrix
TL;DR: Exosomes may play important roles regarding intercellular signaling between granulosa cells and have significant applications in regenerative medicine, targeted therapy, and assisted reproduction technologies. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Sources: ORCID, Web Of Science, NC State University Libraries
Added: July 29, 2023

2023 review

Small extracellular vesicles - A host for advanced bioengineering and "Trojan Horse" of non-coding RNAs

[Review of ]. LIFE SCIENCES, 332.

By: A. Bryja*, L. Zadka*, M. Farzaneh*, M. Zehtabi*, M. Ghasemian*, M. Dyszkiewicz-Konwinska*, P. Mozdziak n, M. Zabel* ...

author keywords: Small extracellular vesicles; Non -coding RNAs; Therapeutic agent; Exosomes; cancer
TL;DR: It is important to consider the fundamental attributes of sEVs and ncRNAs, including by an in-depth analysis of the practical and clinical potentials of exosomes, serving as a representative model for s EVs encapsulating nc RNAs. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (OpenAlex)
Sources: Web Of Science, NC State University Libraries
Added: November 27, 2023

2023 journal article

Spermatogenesis regeneration by transfected spermatogonial stem cells in infertile roosters through testicular transplantation

THERIOGENOLOGY, 198, 100–106.

By: K. Rasouli-Gharehsaghal*, M. Shakeri, M. Zhandi*, H. Amini*, F. Ghadimi*, A. Golkar-Narenji n, P. Mozdziak n

author keywords: Regeneration; Rooster; Spermatogenesis; Transfected; Transplantation
MeSH headings : Animals; Male; Female; Testis; Spermatogonia / metabolism; Chickens; Spermatogenesis / genetics; Infertility / veterinary; Stem Cells
TL;DR: Overall, it seems that regeneration of spermatogenesis in roosters via transfected SSCs is possible but more studies are need to produce recombinant proteins by this way. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Sources: Web Of Science, NC State University Libraries
Added: February 6, 2023

2023 article

The Mechanisms of Long Non-coding RNA-XIST in Ischemic Stroke: Insights into Functional Roles and Therapeutic Potential

Farzaneh, M., Anbiyaee, O., Azizidoost, S., Nasrolahi, A., Ghaedrahmati, F., Kempisty, B., … Najafi, S. (2023, November 6). MOLECULAR NEUROBIOLOGY, Vol. 11.

By: M. Farzaneh*, O. Anbiyaee*, S. Azizidoost*, A. Nasrolahi*, F. Ghaedrahmati*, B. Kempisty n, P. Mozdziak n, S. Khoshnam*, S. Najafi*

author keywords: Ischemic stroke; LncRNAs; XIST; miRNA; Pathogenesis
TL;DR: A comprehensive summary of the functional roles of X-inactive specific transcript in ischemic stroke is provided, which aims to enhance the understanding of the mechanisms underlying isChemic stroke and potentially identify novel therapeutic targets. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (OpenAlex)
Sources: Web Of Science, NC State University Libraries
Added: November 27, 2023

2023 review

The Role of Exosomes in Human Carcinogenesis and Cancer Therapy-Recent Findings from Molecular and Clinical Research

[Review of ]. CELLS, 12(3).

By: K. Stefanska*, M. Jozkowiak*, A. Angelova Volponi*, J. Shibli*, A. Golkar-Narenji n, P. Antosik*, D. Bukowska*, H. Piotrowska-Kempisty* ...

author keywords: exosomes; cancer; drug resistance; cancer therapies
MeSH headings : Animals; Humans; Exosomes / physiology; Neoplasms / pathology; Drug Carriers / therapeutic use; Drug Delivery Systems; Carcinogenesis; Mammals
TL;DR: It is important to consider the current knowledge regarding the role of exosomes in cancer, drug resistance, cancer therapies, and their clinical application in cancer therapies. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (Web of Science; OpenAlex)
Sources: ORCID, Web Of Science, NC State University Libraries
Added: January 23, 2023

2023 journal article

Transcriptomic Characterization of Genes Regulating the Stemness in Porcine Atrial Cardiomyocytes during Primary In Vitro Culture

Genes.

TL;DR: The establishment and detailed characterization of in vitro culture of myocardial cells may be important for future applications of these cells in heart regeneration processes. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (Web of Science; OpenAlex)
Source: ORCID
Added: June 9, 2023

2023 review

Unveiling Mesenchymal Stem Cells' Regenerative Potential in Clinical Applications: Insights in miRNA and lncRNA Implications

[Review of ]. CELLS, 12(21).

By: M. Jankowski*, M. Farzaneh*, F. Ghaedrahmati*, M. Shirvaliloo*, A. Moalemnia*, M. Kulus*, H. Ziemak*, M. Chwarzynski* ...

author keywords: mesenchymal stem cells; miRNA; lncRNA
TL;DR: The literature containing the latest discoveries pertaining to human stem cells and their potential in both fundamental research and clinical applications is collected, shedding light on the opportunities presented by harnessing the regulatory potential of miRNAs and lncRNAs. (via Semantic Scholar)
Sources: Web Of Science, NC State University Libraries, ORCID
Added: November 27, 2023

2022 review

Artificial-Intelligence-Based Imaging Analysis of Stem Cells: A Systematic Scoping Review

[Review of ]. BIOLOGY-BASEL, 11(10).

By: J. Issa, M. Abou Chaar*, B. Kempisty*, L. Gasiorowski, R. Olszewski, P. Mozdziak*, M. Dyszkiewicz-Konwinska

author keywords: artificial intelligence; stem cells; induced pluripotent stem cells; embryonic stem cells; adult stem cells; imaging
TL;DR: This systematic scoping review aimed to identify and map the available artificial-intelligence-based techniques for imaging analysis, the characterization of stem cell differentiation, and trans-differentiation pathways and guide and help researchers while planning for future investigations. (via Semantic Scholar)
Sources: ORCID, Web Of Science, NC State University Libraries
Added: October 3, 2022

2022 review

Cancer Stem Cells-The Insight into Non-Coding RNAs

[Review of ]. CELLS, 11(22).

By: R. Bryl, O. Piwocka*, E. Kawka, P. Mozdziak n, B. Kempisty n & A. Knopik-Skrocka*

author keywords: cancer stem cells; non-coding RNAs; EMT; phenotypic and metabolic plasticity; anti-cancer therapies
TL;DR: Cancer stem cells have claimed to be one of the most important group of cells for the development of several common cancers as they dictate features, such as resistance to radio- and chemotherapy, metastasis, and secondary tumor formation. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (Web of Science; OpenAlex)
Sources: ORCID, Web Of Science, NC State University Libraries
Added: November 23, 2022

2022 journal article

Cellular Processes in Human Ovarian Follicles Are Regulated by Expression Profile of New Gene Markers-Clinical Approach

JOURNAL OF CLINICAL MEDICINE, 11(1).

By: B. Chermula*, W. Kranc*, P. Celichowski*, B. Stelmach*, H. Piotrowska-Kempisty*, P. Mozdziak n, L. Pawelczyk*, R. Spaczynski*, B. Kempisty n

author keywords: cumulus cells; granulosa cells; human; gene expression; microarray; epithelialization
TL;DR: Detailed analysis of gene expression in these two cell populations at different time intervals confirms their ovarian surface epithelial origin, and some gene expression profiles appear to have tumorigenic properties, suggesting that granulosa cells may play a role in cancerogenesis. (via Semantic Scholar)
Sources: Web Of Science, NC State University Libraries, ORCID
Added: December 29, 2021

2022 journal article

Expression Profile of New Gene Markers Involved in Differentiation of Canine Adipose-Derived Stem Cells into Chondrocytes

GENES, 13(9).

By: M. Jankowski*, M. Kaczmarek*, G. Wasiatycz*, A. Konwerska*, C. Dompe*, D. Bukowska*, P. Antosik*, P. Mozdziak n, B. Kempisty n

author keywords: adipose; stem cells; chondrocytes; differentiation; RNAseq; transcriptomics
MeSH headings : Adipose Tissue / metabolism; Animals; Chondrocytes / metabolism; Culture Media / metabolism; Dogs; Genetic Markers; Matrix Metalloproteinase 12 / metabolism; Osteoarthritis / genetics; Osteoarthritis / metabolism; RNA / metabolism; Stem Cells
TL;DR: The results of the study prove the usefulness of the in vitro culture model, providing further molecular insight into the processes associated with ASC culture and differentiation, and could be used for future in vivo and clinical studies. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (Web of Science; OpenAlex)
5. Gender Equality (Web of Science)
Sources: ORCID, Web Of Science, NC State University Libraries
Added: September 21, 2022

2022 review

Fetomaternal Expression of Glucose Transporters (GLUTs)-Biochemical, Cellular and Clinical Aspects

[Review of ]. NUTRIENTS, 14(10).

By: R. Sibiak*, K. Ozegowska*, E. Wender-Ozegowska*, P. Gutaj*, P. Mozdziak n & B. Kempisty n

author keywords: diabetes; glucose transporter proteins; hyperglycemia in pregnancy; placenta; pregnancy
MeSH headings : Biological Transport; Female; Glucose / metabolism; Glucose Transport Proteins, Facilitative / genetics; Glucose Transport Proteins, Facilitative / metabolism; Humans; Placenta / metabolism; Pregnancy; Protein Isoforms
TL;DR: Several types of specialized glucose transporters provide constant glucose transport from the maternal circulation to the developing fetus through the placental barrier from the early stages of pregnancy, and most studies have found no between-group differences in GLUTs’ placental expression in macrosomic and normal control pregnancies. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (Web of Science; OpenAlex)
5. Gender Equality (Web of Science)
Sources: ORCID, Web Of Science, NC State University Libraries
Added: May 17, 2022

2022 journal article

Gene Ontology Groups and Signaling Pathways Regulating the Process of Avian Satellite Cell Differentiation

Genes.

MeSH headings : Animals; Cell Culture Techniques / methods; Cell Differentiation / genetics; Gene Ontology; Myoblasts; Signal Transduction / genetics
TL;DR: It seems that suspension cultures, often considered the desired method for in vitro meat production, require further investigation to fully elucidate their effect on myosatellite cells and, therefore, possibly enable their easier scalability to ensure suitability for industrial application. (via Semantic Scholar)
UN Sustainable Development Goal Categories
2. Zero Hunger (Web of Science; OpenAlex)
13. Climate Action (Web of Science)
Source: ORCID
Added: February 1, 2022

2022 review

The Potential of a Protein Model Synthesized Absent of Methionine

[Review of ]. MOLECULES, 27(12).

By: R. Savino n, B. Kempisty n & P. Mozdziak n

author keywords: methionine; cysteine; antioxidant; protein; cell; stability; protein synthesis
MeSH headings : Amino Acids; Antioxidants; Cysteine / metabolism; Methionine / chemistry; Proteins / chemistry
TL;DR: A number of novel mechanisms for alternative initiation of protein synthesis have been identified that suggest a potential to bypass the traditional methionine-dependent initiation during times of stress, and a number of examples that demonstrate a potential model for synthesizing a protein in the absence of methamphetamine are discussed. (via Semantic Scholar)
Sources: ORCID, Web Of Science, NC State University Libraries
Added: June 13, 2022

2022 review

The pathogenic roles of lncRNA-Taurine upregulated 1 (TUG1) in colorectal cancer

[Review of ]. CANCER CELL INTERNATIONAL, 22(1).

By: S. Azizidoost*, A. Nasrolahi*, F. Ghaedrahmati*, B. Kempisty n, P. Mozdziak n, K. Radoszkiewicz*, M. Farzaneh*

author keywords: Colorectal cancer; LncRNAs; TUG1; Tumorigenesis
TL;DR: The scientific literature reports that altered expression of long non-coding RNAs (lncRNAs) contributed to the pathogenesis of CRC cells, and TUG1 might be a potent predictive/prognostic biomarker for diagnosis of CRC. (via Semantic Scholar)
Sources: Web Of Science, NC State University Libraries
Added: November 21, 2022

2022 journal article

Transcriptomic Profile of Genes Regulating the Structural Organization of Porcine Atrial Cardiomyocytes during Primary In Vitro Culture

GENES, 13(7).

author keywords: cardiomyocyte structure; cytoskeleton organization; extracellular matrix; cell culture; transcriptomic analysis
MeSH headings : Animals; Collagen / metabolism; Extracellular Matrix / metabolism; Heart Atria; Myocardium / metabolism; Myocytes, Cardiac / metabolism; Swine; Transcriptome
TL;DR: A transcriptomic profile of atrial cardiomyocytes during long-term primary cell culture revealed the expression patterns depending on the duration of the culture and the heart segment of origin (right atrial appendage and right atrium); genes important for cellular architecture, such as ABLIM1, TMOD1, XIRP1, and PHACTR1, were downregulated during in vitro culture. (via Semantic Scholar)
Sources: ORCID, Web Of Science, NC State University Libraries
Added: July 10, 2022

2021 review

COVID-19 Pandemic Is a Call to Search for Alternative Protein Sources as Food and Feed: A Review of Possibilities

[Review of ]. NUTRIENTS, 13(1), 150.

MeSH headings : Animals; COVID-19 / epidemiology; COVID-19 / etiology; COVID-19 / prevention & control; Dietary Proteins / supply & distribution; Edible Insects; Food; Food Supply / methods; Humans; Meat; Plants, Edible; Zoonoses / etiology; Zoonoses / prevention & control
TL;DR: There is a need to further support the implementation and expansion of all three approaches discussed in this paper, plant-based diets, insect-based foods, and cultured meat, to decrease the epidemiological risks and ensure a sustainable future. (via Semantic Scholar)
Sources: ORCID, Web Of Science, NC State University Libraries
Added: January 10, 2021

2021 journal article

Design and Immunological Evaluation of a Hybrid Peptide as a Potent TLR2 Agonist by Structure-Based Virtual Screening

FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY, 9.

By: L. Zhang*, X. Wei n, R. Zhang*, P. Mozdziak n, D. Si*, B. Ahmad*, Q. Cheng*, Y. Tong*

author keywords: immunoregulatory activity; TLR2; molecule docking; cyclophosphamide; NF-κ B signaling
TL;DR: It is revealed that LTPa successfully inhibit immunosuppression, increased immune organ indices, enhanced DC maturation, regulated T lymphocyte subsets, and increased cytokine and Ig contents, and the immunomodulatory effects of L TPa are associated with binding to TLR2, forming TLR 2 clusters, and activating the NF-κB signaling pathway. (via Semantic Scholar)
Sources: Web Of Science, NC State University Libraries
Added: March 15, 2021

2021 journal article

Expression Profile of Genes Encoding Proteins Involved in Regulation of Vasculature Development and Heart Muscle Morphogenesis-A Transcriptomic Approach Based on a Porcine Model

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, 22(16).

author keywords: coronary vessels; neovascularization; cell culture; transcriptomic analysis
MeSH headings : Animals; Cells, Cultured; Coronary Vessels / chemistry; Coronary Vessels / growth & development; Gene Expression Profiling / methods; Gene Expression Regulation, Developmental; Gene Regulatory Networks; Muscle Development; Myocardium / chemistry; Myocardium / cytology; Oligonucleotide Array Sequence Analysis; Primary Cell Culture; Swine; Exome Sequencing
TL;DR: Transcriptomic comparative analysis between two different compartments of the heart muscle allowed us to indicate the presence of differences in the expression of key transcripts depending on the cell source, including SFRP2, PRRX1, and some other genes involved in inflammatory process. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (Web of Science; OpenAlex)
Sources: ORCID, Web Of Science, NC State University Libraries
Added: August 21, 2021

2021 journal article

Expression Profile of New Gene Markers and Signaling Pathways Involved in Immunological Processes in Human Cumulus-Oophorus Cells

GENES, 12(9).

By: B. Chermula*, G. Hutchings*, W. Kranc*, M. Jozkowiak*, K. Jopek*, B. Stelmach*, P. Mozdziak n, L. Pawelczyk* ...

author keywords: cumulus cells; cytokine action; IVF
MeSH headings : Adult; Cell Proliferation / genetics; Cells, Cultured; Cumulus Cells / immunology; Cumulus Cells / metabolism; Cytokines / metabolism; Female; Fertilization in Vitro; Gene Expression Profiling; Humans; Immunity / genetics; Oocytes / immunology; Oocytes / metabolism; Ovulation / genetics; Ovulation / immunology; Ovulation Induction; Primary Cell Culture; Signal Transduction / genetics; Signal Transduction / immunology; Up-Regulation / immunology
TL;DR: G genes involved in immunological defense processes are upregulated in CC cultures and could serve as useful molecular markers of growth and development in the COC, as well as the proliferation of granulosa and cumulus cells. (via Semantic Scholar)
Sources: ORCID, Web Of Science, NC State University Libraries
Added: September 5, 2021

2021 journal article

Expression Profile of New Marker Genes Involved in Differentiation of Canine Adipose-Derived Stem Cells into Osteoblasts

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, 22(13).

By: M. Jankowski*, M. Kaczmarek*, G. Wasiatycz*, C. Dompe*, P. Mozdziak n, J. Jaskowski*, H. Piotrowska-Kempisty*, B. Kempisty n

author keywords: adipose; stem cells; RNAseq; transcriptome; analysis
MeSH headings : Adipose Tissue / cytology; Animals; Cell Differentiation; Dogs; Gene Expression Profiling; Gene Expression Regulation; Osteoblasts / metabolism; Osteogenesis / genetics; Sequence Analysis, RNA; Stem Cells / metabolism; Stem Cells / physiology; Transcriptome
TL;DR: The results of this study provide molecular insight into the processes that occur during long-term in vitro culture and osteogenic differentiation of ASCs, allowing the re-evaluation of the roles of some genes in MSC progression towards a range of lineages. (via Semantic Scholar)
Sources: ORCID, Web Of Science, NC State University Libraries
Added: June 24, 2021

2021 review

Human Granulosa Cells-Stemness Properties, Molecular Cross-Talk and Follicular Angiogenesis

[Review of ]. CELLS, 10(6).

By: C. Dompe*, M. Kulus*, K. Stefanska*, W. Kranc*, B. Chermula*, R. Bryl*, W. Pienkowski*, M. Nawrocki* ...

author keywords: stem cells; granulosa cells; cumulus cells; translational medicine; miRNA; follicular angiogenesis
MeSH headings : Cumulus Cells / metabolism; Female; Humans; Neovascularization, Physiologic; Polycystic Ovary Syndrome / metabolism; Primary Ovarian Insufficiency / metabolism; Stem Cells / metabolism
TL;DR: It is important to carefully consider GCs as ovarian stem cells in terms of the cellular features and molecular pathways involved in their development and interactions as well as outline their possible application in translational medicine. (via Semantic Scholar)
Sources: ORCID, Web Of Science, NC State University Libraries
Added: June 10, 2021

2021 journal article

Mesenchymal Stem/Stromal Cells Derived from Human and Animal Perinatal Tissues-Origins, Characteristics, Signaling Pathways, and Clinical Trials

CELLS, 10(12).

By: M. Kulus*, R. Sibiak*, K. Stefanska*, M. Zdun*, M. Wieczorkiewicz*, H. Piotrowska-Kempisty*, J. Jaskowski*, D. Bukowska* ...

author keywords: perinatal mesenchymal stem; stromal cells; MSCs differentiation; signaling pathways
MeSH headings : Amniotic Fluid / cytology; Cell Differentiation / genetics; Cell Lineage / genetics; Cell Self Renewal / genetics; Embryonic Stem Cells / cytology; Embryonic Stem Cells / transplantation; Female; Humans; Mesenchymal Stem Cell Transplantation; Mesenchymal Stem Cells / cytology; Placenta / cytology; Placenta / transplantation; Pregnancy; Regenerative Medicine; Umbilical Cord / cytology; Umbilical Cord / transplantation
TL;DR: It is important to consider the origin of these cells, referring to the anatomical structure of the organs of origin, when describing the general and specific characteristics of the different types of MSCs as well as the pathways involved in differentiation. (via Semantic Scholar)
Sources: ORCID, Web Of Science, NC State University Libraries
Added: November 28, 2021

2021 review

Molecular Mechanisms Associated with ROS-Dependent Angiogenesis in Lower Extremity Artery Disease

[Review of ]. ANTIOXIDANTS, 10(5).

By: G. Hutchings*, L. Kruszyna*, M. Nawrocki*, E. Strauss*, R. Bryl*, J. Spaczynska*, B. Perek*, M. Jemielity* ...

author keywords: peripheral arterial diseases; angiogenesis; neovascularization; atherosclerosis
UN Sustainable Development Goal Categories
3. Good Health and Well-being (Web of Science; OpenAlex)
Sources: ORCID, Web Of Science, NC State University Libraries
Added: May 12, 2021

2021 journal article

New Gene Markers Expressed in Porcine Oviductal Epithelial Cells Cultured Primary In Vitro Are Involved in Ontological Groups Representing Physiological Processes of Porcine Oocytes

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, 22(4).

By: M. Kulus*, W. Kranc*, K. Wojtanowicz-Markiewicz*, P. Celichowski*, A. Swiatly-Blaszkiewicz*, E. Matuszewska*, P. Sujka-Kordowska*, A. Konwerska* ...

author keywords: pig; epithelial cells; microarray assays; long-term in vitro culture; oviduct; transcriptomics; proteomics
MeSH headings : Animals; Cell Differentiation / genetics; Cell Shape / genetics; Cells, Cultured; Down-Regulation / genetics; Epithelial Cells / metabolism; Female; Gene Expression Regulation; Gene Ontology; Gene Regulatory Networks; Genetic Markers; Oocytes / metabolism; Oviducts / cytology; Signal Transduction / genetics; Swine; Transcriptome; Up-Regulation / genetics
TL;DR: The aim of the study was to assess the expression profile of genes in primary in vitro cultured oviductal epithelial cells (OECs), clustered in Gene Ontology groups which enveloped markers also identified in porcine oocytes. (via Semantic Scholar)
Sources: ORCID, Web Of Science, NC State University Libraries
Added: February 24, 2021

2021 review

Ovarian Cancer and Cancer Stem Cells-Cellular and Molecular Characteristics, Signaling Pathways, and Usefulness as a Diagnostic Tool in Medicine and Oncology

[Review of ]. CANCERS, 13(16).

author keywords: ovarian cancer; cancer stem cells; molecular markers; ovarian tumor
TL;DR: Current histological classification of ovarian tumors, their epidemiology, and the most recent knowledge of ovarian CSCs, with particular emphasis on their molecular background, are presented and the importance of signaling pathways involved in tumor growth, development, and metastasis, is presented. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (Web of Science; OpenAlex)
Sources: ORCID, Web Of Science, NC State University Libraries
Added: August 24, 2021

2021 journal article

Photobiomodulation with Red and Near-Infrared Light Improves Viability and Modulates Expression of Mesenchymal and Apoptotic-Related Markers in Human Gingival Fibroblasts

MATERIALS, 14(12).

By: I. Kocherova*, A. Bryja*, K. Blochowiak*, M. Kaczmarek*, K. Stefanska*, J. Matys*, K. Grzech-Lesniak*, M. Dominiak* ...

author keywords: low-level laser treatment; LLLT; photobiomodulation; PBM; human gingival fibroblasts; in vitro
TL;DR: PBM with both 635 and 808 nm at 4 J/cm2 increased the cell number, modulated extracellular oxidative stress and inflammation markers and decreased the susceptibility of human primary gingival fibroblasts to apoptosis through the downregulation of apoptotic-related genes. (via Semantic Scholar)
UN Sustainable Development Goal Categories
7. Affordable and Clean Energy (OpenAlex)
Sources: ORCID, Web Of Science, NC State University Libraries
Added: June 24, 2021

2021 review

SARS-CoV-2 Genetic Variability and Non-Specific Immunity Associated with the Use of Different BCG Strains-A Molecular and Clinical Approach

[Review of ]. VACCINES, 9(6).

author keywords: SARS-CoV-2; COVID-19; BCG vaccinations; genetic variability; WHO recommendation; variants; tuberculosis
TL;DR: It is remembered that the large variation in the genetic makeup of SARS-CoV-2 may result in future changes in its pathogenicity, immunogenicity and antigenicity, and therefore it is necessary to carefully study the mutations occurring within the virus to determine whether the current vaccines will remain effective. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (Web of Science; OpenAlex)
Sources: ORCID, Web Of Science, NC State University Libraries
Added: June 16, 2021

2021 journal article

Small Extracellular Vesicles and COVID19-Using the "Trojan Horse" to Tackle the Giant

CELLS, 10(12).

author keywords: COVID-19; SARS-CoV-2; exosomes; extracellular vesicles
MeSH headings : Animals; COVID-19 / epidemiology; COVID-19 / therapy; COVID-19 / virology; Exosomes / metabolism; Extracellular Vesicles / metabolism; Humans; Models, Biological; SARS-CoV-2 / physiology
TL;DR: The role of EVs in promoting the viral spread by evading the immune response of the host, which is exhibited by retroviruses, indicates the potential for further investigation and possible manipulation of these processes when tackling the spread and treatment of COVID-19. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (Web of Science; OpenAlex)
Sources: ORCID, Web Of Science, NC State University Libraries
Added: December 6, 2021

2021 journal article

Transcriptomic Profile of New Gene Markers Encoding Proteins Responsible for Structure of Porcine Ovarian Granulosa Cells

BIOLOGY-BASEL, 10(11).

By: J. Kulus*, M. Kulus*, W. Kranc*, K. Jopek*, M. Zdun*, M. Jozkowiak*, J. Jaskowski*, H. Piotrowska-Kempisty* ...

author keywords: porcine granulosa cells; extracellular matrix; gene expression profile; folliculogenesis; reproductive physiology
TL;DR: The aim of this study was to describe the expression profile of genes within granulosa cells that are associated with extracellular matrix formation, intercellular signaling, and cell–cell fusion. (via Semantic Scholar)
Sources: ORCID, Web Of Science, NC State University Libraries
Added: November 25, 2021

2021 journal article

Transcriptomic and Morphological Analysis of Cells Derived from Porcine Buccal Mucosa-Studies on an In Vitro Model

ANIMALS, 11(1).

By: A. Bryja*, G. Latosinski*, M. Jankowski*, A. Angelova Volponi*, P. Mozdziak n, J. Shibli*, R. Bryl*, J. Spaczynska* ...

author keywords: cell culture; oral mucosa; fibroblasts; DIC imaging
TL;DR: In vitro expanded porcine oral mucosal cells, consisting of populations of epithelial and connective lineages, are interesting and complex systems for study via microarray transcriptomic assays to analyze gene expression profile. (via Semantic Scholar)
Sources: Web Of Science, NC State University Libraries, ORCID
Added: December 29, 2020

2020 journal article

A highly efficient hybrid peptide ameliorates intestinal inflammation and mucosal barrier damage by neutralizing lipopolysaccharides and antagonizing the lipopolysaccharide-receptor interaction

FASEB JOURNAL, 34(12), 16049–16072.

By: X. Wei*, L. Zhang*, R. Zhang*, R. Wu*, D. Si*, B. Ahmad*, J. Petitte n, P. Mozdziak n ...

author keywords: in silico; NF-kappa B signaling; peptide drug; proinflammatory cytokine; tight junction; Toll-like receptor
MeSH headings : Animals; Anti-Inflammatory Agents / pharmacology; Antimicrobial Cationic Peptides / pharmacology; Cell Line; Inflammation / chemically induced; Inflammation / drug therapy; Inflammation / metabolism; Interleukin-6 / metabolism; Intestinal Mucosa / drug effects; Intestinal Mucosa / metabolism; Lipopolysaccharides / pharmacology; Male; Mice; Mice, Inbred C57BL; Mucous Membrane / drug effects; Mucous Membrane / metabolism; NF-kappa B / metabolism; Peptides / pharmacology; RAW 264.7 Cells; Signal Transduction / drug effects; Toll-Like Receptor 4 / metabolism; Tumor Necrosis Factor-alpha / metabolism
TL;DR: A novel hybrid anti‐inflammatory peptide that combines the active center of Cecropin A and the core functional region of LL‐37 (L) was designed through in silico analysis to reduce cytotoxicity and improve the anti-inflammatory activity of the parental peptides, suggesting that the newly designed peptide, C‐L, could be developed into a novel anti‐ inflammatory agent for animals or humans. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (Web of Science; OpenAlex)
Sources: Web Of Science, NC State University Libraries
Added: November 9, 2020

2020 journal article

Avian Satellite Cell Plasticity

Animals, 10(8), 1322.

author keywords: satellite cells; plasticity; stem cells; chicken; embryo
TL;DR: The results of this study proved the high myogenicity of chicken Pectoralis thoracicus cell isolates, as well as provided new information about their migration pathways following introduction into the blastocyst. (via Semantic Scholar)
Source: ORCID
Added: August 5, 2020

2020 journal article

Bone Regeneration, Reconstruction and Use of Osteogenic Cells; from Basic Knowledge, Animal Models to Clinical Trials

Journal of Clinical Medicine.

By: G. Hutchings*, L. Moncrieff*, C. Dompe*, K. Janowicz*, R. Sibiak*, A. Bryja*, M. Jankowski*, . mozdziak n ...

author keywords: bone; regeneration; reconstruction; osteogenesis; stem; cells
TL;DR: The following review summarizes the latest studies and clinical trials related to the use of MSCs, both individually and combined with other methods, in the treatment of a variety of conditions related to skeletal health. (via Semantic Scholar)
Source: ORCID
Added: January 9, 2020

2020 personal communication

COVID-19 spotlights medical diagnostics

Jankowski, M., Mozdziak, P., & Kempisty, B. (2020, May 22).

By: M. Jankowski*, P. Mozdziak n & B. Kempisty*

MeSH headings : COVID-19; COVID-19 Testing; Clinical Laboratory Techniques; Coronavirus Infections / diagnosis; Diagnosis; Humans; Medicine; Pandemics; Pneumonia, Viral / diagnosis
Sources: Web Of Science, NC State University Libraries
Added: June 22, 2020

2020 review

CRISPR/Cas9 in Cancer Immunotherapy: Animal Models and Human Clinical Trials

[Review of ]. GENES, 11(8).

By: K. Khalaf*, K. Janowicz*, M. Dyszkiewicz-Konwinska*, G. Hutchings*, C. Dompe*, L. Moncrieff*, M. Jankowski*, M. Machnik* ...

author keywords: genome editing; cancer; animal models; experimental oncology
MeSH headings : Animals; CRISPR-Cas Systems; Clinical Trials as Topic; Disease; Disease Models, Animal; Drug Evaluation, Preclinical; Gene Editing; Genetic Therapy; Humans; Immunotherapy; Immunotherapy, Adoptive; Neoplasms / etiology; Neoplasms / therapy; Precision Medicine / methods
TL;DR: The aim of the article is to present the knowledge concerning the use of CRISPR Cas9 technique in targeting treatment-resistant cancers, and to present an overview of the limitations of the gene-editing tool. (via Semantic Scholar)
Sources: Web Of Science, NC State University Libraries, ORCID
Added: November 2, 2020

2020 journal article

Cortical Granule Distribution and Expression Pattern of Genes Regulating Cellular Component Size, Morphogenesis, and Potential to Differentiation are Related to Oocyte Developmental Competence and Maturational Capacity In Vivo and In Vitro

GENES, 11(7).

By: M. Kulus*, W. Kranc*, M. Jeseta*, P. Sujka-Kordowska*, A. Konwerska*, S. Ciesiolka*, P. Celichowski*, L. Moncrieff* ...

author keywords: pig; oocyte maturation; microarray; cortical granule; molecular markers
MeSH headings : Animals; Cell Differentiation; Cells, Cultured; Cytoplasmic Granules / metabolism; Female; In Vitro Oocyte Maturation Techniques / methods; Oocytes / cytology; Oocytes / metabolism; Swine; Transcriptome
TL;DR: The expression profile of genes that may be associated with cortical reactions are explored, the distribution of CGs in immature oocytes is evaluated, and movement towards the cortical zone of the oocyte during meiotic competence acquisition was observed. (via Semantic Scholar)
Sources: Web Of Science, NC State University Libraries, ORCID
Added: August 24, 2020

2020 review

Designing A Transgenic Chicken: Applying New Approaches toward A Promising Bioreactor

[Review of ]. CELL JOURNAL, 22(2), 133–139.

By: S. Bahrami*, A. Amiri-Yekta*, A. Daneshipour*, S. Jazayeri*, P. Mozdziak n, M. Sanati*, H. Gourabi*

author keywords: Chickens; CRISPR/Cas9; Ovalbumin; Recombinant Protein; Transgenes
TL;DR: The new approaches and technologies that can be applied to generate a transgenic chicken with regards to recombinant protein productions are discussed. (via Semantic Scholar)
UN Sustainable Development Goal Categories
2. Zero Hunger (OpenAlex)
Sources: Web Of Science, NC State University Libraries, ORCID
Added: December 16, 2019

2020 journal article

Epigenetic Research in Stem Cell Bioengineering—Anti-Cancer Therapy, Regenerative and Reconstructive Medicine in Human Clinical Trials

Cancers.

By: C. Dompe*, K. Janowicz*, G. Hutchings*, L. Moncrieff*, M. Jankowski*, M. Nawrocki*, M. Józkowiak*, . mozdziak n ...

TL;DR: A large number of currently designed or tested clinical approaches, based on compounds regulating epigenetic pathways in various types of tumour formation, malignancy and metastasis, employ these mechanisms in stem cell bioengineering. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (Web of Science; OpenAlex)
Source: ORCID
Added: April 26, 2020

2020 journal article

Expression of Selected Connexin and Aquaporin Genes and Real-Time Proliferation of Porcine Endometrial Luminal Epithelial Cells in Primary Culture Model

BIOMED RESEARCH INTERNATIONAL, 2020.

By: K. Wojtanowicz-Markiewicz*, M. Kulus*, S. Knap*, I. Kocherova*, M. Jankowski*, K. Stefanska*, M. Jeseta*, H. Piotrowska-Kempisty* ...

MeSH headings : Animals; Aquaporins / genetics; Aquaporins / metabolism; Cell Culture Techniques; Cell Proliferation / genetics; Cell Shape; Cells, Cultured; Connexins / genetics; Connexins / metabolism; Endometrium / cytology; Epithelial Cells / metabolism; Female; Gene Expression Regulation; Models, Biological; Swine
TL;DR: This study showed that the significant changes were noted in the case of Cx43, whose level of protein expression and distribution increases after 120 hours of culture, when the cells enter the lag phase, and maintains an upward trend until the end of the culture. (via Semantic Scholar)
UN Sustainable Development Goal Categories
6. Clean Water and Sanitation (OpenAlex)
Sources: Web Of Science, NC State University Libraries
Added: March 16, 2020

2020 journal article

Genes regulating hormone stimulus and response to protein signaling revealed differential expression pattern during porcine oocyte in vitro maturation, confirmed by lipid concentration

HISTOCHEMISTRY AND CELL BIOLOGY, 154(1), 77–95.

By: B. Chermula*, M. Jeseta*, P. Sujka-Kordowska*, A. Konwerska*, M. Jankowski*, W. Kranc*, I. Kocherova*, P. Celichowski* ...

author keywords: Pig; Oocyte maturation; Microarray; Mitochondrial activity
MeSH headings : Animals; Cells, Cultured; Eosine Yellowish-(YS) / chemistry; Female; Hematoxylin / chemistry; Hormones / genetics; Hormones / metabolism; In Vitro Oocyte Maturation Techniques; Lipids / analysis; Oocytes / growth & development; Oocytes / metabolism; Oxazines / chemistry; Signal Transduction; Swine
TL;DR: The results of the study may serve as a basic molecular reference for further research aimed at improving the methods of oocyte in vitro maturation, which plays an important role in the procedures of assisted reproduction. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Sources: Web Of Science, NC State University Libraries
Added: April 6, 2020

2020 journal article

Human Cumulus Cells in Long-Term In Vitro Culture Reflect Differential Expression Profile of Genes Responsible for Planned Cell Death and Aging—A Study of New Molecular Markers

Cells.

By: B. Chermuła*, W. Kranc*, K. Jopek*, Joanna, G. Hutchings*, C. Dompe*, L. Moncrieff*, K. Janowicz* ...

author keywords: cumulus cells; human; programmed cell death; gene expression
MeSH headings : Adult; Biomarkers / metabolism; Cell Culture Techniques / methods; Cell Death / genetics; Cell Shape / genetics; Cellular Senescence / genetics; Cumulus Cells / cytology; Cumulus Cells / metabolism; Gene Expression Profiling; Gene Expression Regulation; Gene Ontology; Gene Regulatory Networks; Humans; Principal Component Analysis; Reproducibility of Results; Time Factors
TL;DR: Long-term in vitro culture of CCs collected from patients undergoing controlled ovarian stimulation during in vitro fertilization procedure was conducted, and particular attention was paid to genes involved in programmed cell death, aging, and apoptosis. (via Semantic Scholar)
Source: ORCID
Added: May 26, 2020

2020 journal article

Human Wharton’s Jelly—Cellular Specificity, Stemness Potency, Animal Models, and Current Application in Human Clinical Trials

Journal of Clinical Medicine.

By: K. Stefańska*, K. Ożegowska*, G. Hutchings*, M. Popis*, L. Moncrieff*, C. Dompe*, K. Janowicz*, W. Pieńkowski* ...

author keywords: stem cells; Wharton's jelly; umbilical cord
TL;DR: Umbilical cord, especially Wharton’s jelly, is a promising source of mesenchymal stem cells, which makes them a good alternative for allogeneic and xenogeneic transplantations in cellular therapies. (via Semantic Scholar)
Source: ORCID
Added: April 17, 2020

2020 journal article

Immunoglobulin J chain as a non-invasive indicator of pregnancy in the cheetah (Acinonyx jubatus)

PLOS ONE.

Paul Mozdziak

MeSH headings : Acinonyx / physiology; Animals; Animals, Zoo; Biomarkers / analysis; Biomarkers / metabolism; Estrogens / analysis; Feces / chemistry; Female; Immunoglobulin J-Chains / analysis; Immunoglobulin J-Chains / metabolism; Luteal Phase / immunology; Male; Ovulation Induction; Pregnancy / immunology; Progestins / analysis; Reproduction / immunology; Semen; Sexual Behavior, Animal; United States
TL;DR: It was revealed that IgJ abundance was increased in pregnant females compared to non-pregnant females at week 4 and week 8 post-breeding, indicating the potential modulation of maternal immunity in response to sensitive events such as implantation and the increased secretory activity of the placenta. (via Semantic Scholar)
UN Sustainable Development Goal Categories
15. Life on Land (Web of Science; OpenAlex)
Source: ORCID
Added: February 12, 2020

2020 journal article

In Vitro Cultures of Adipose-Derived Stem Cells: An Overview of Methods, Molecular Analyses, and Clinical Applications

Cells.

author keywords: adipose-derived stem cells; clinical trials; molecular studies; in vitro
MeSH headings : Adipocytes / cytology; Adipocytes / metabolism; Cell Culture Techniques; Cell Differentiation; Humans; Models, Animal
TL;DR: In vitro studies will most likely continue to play a significant role in ASC studies, both providing the molecular knowledge of their ex vivo properties and possibly serving as an important step in purification and application of those cells in a clinical setting. (via Semantic Scholar)
Source: ORCID
Added: August 1, 2020

2020 journal article

Inclusion Biogenesis, Methods of Isolation and Clinical Application of Human Cellular Exosomes

Journal of Clinical Medicine.

By: M. Tschuschke*, I. Kocherova*, A. Bryja*, . mozdziak n, A. Volponi*, K. Janowicz*, R. Sibiak*, H. Piotrowska-Kempisty* ...

author keywords: exosome; neurodegenerative disease; cancer; biomarker; clinical application
TL;DR: This work explored the exosome formation through different systems, including the endosomal sorting complex required for transport (ESCRT) and ESCRT-independent system, looking at the mechanisms of release. (via Semantic Scholar)
Source: ORCID
Added: February 11, 2020

2020 journal article

Muscle Cell Morphogenesis, Structure, Development and Differentiation Processes Are Significantly Regulated during Human Ovarian Granulosa Cells In Vitro Cultivation

Journal of Clinical Medicine.

By: C. Dompe*, W. Kranc*, K. Jopek*, K. Kowalska*, S. Ciesiolka*, B. Chermuła*, A. Bryja*, M. Jankowski* ...

author keywords: human GCs; in vitro culture; proliferation; muscle differentiation
TL;DR: The expression of genes belonging to the mentioned ontological groups suggest the potential ability of GCs to differentiate and proliferate toward muscle lineage, showing possible application in muscle regeneration and the treatment of different diseases. (via Semantic Scholar)
UN Sustainable Development Goal Categories
5. Gender Equality (Web of Science)
Source: ORCID
Added: July 1, 2020

2020 journal article

Myogenic Response to Increasing Concentrations of Ammonia Differs between Mammalian, Avian, and Fish Species: Cell Differentiation and Genetic Study

Genes.

By: E. Miramontes n, B. Kempisty*, J. Petitte n, S. Dasarathy*, M. Kulus*, M. Wieczorkiewicz*, . mozdziak n

author keywords: muscle; ammonia; avian; mammals; fish; myostatin
MeSH headings : Ammonia / pharmacology; Animals; Birds; Cell Differentiation; Fishes; Gene Expression Regulation / drug effects; Humans; Mice; Muscle Development; Muscle, Skeletal / drug effects; Muscle, Skeletal / metabolism; Muscle, Skeletal / pathology; Myostatin / genetics; Myostatin / metabolism
TL;DR: It is confirmed that increasing concentrations of ammonia are detrimental to mammalian skeletal muscle, while chick cells responded positively at lower levels but began to exhibit a negative response at higher levels, as the tilapia experienced no detrimental effects. (via Semantic Scholar)
UN Sustainable Development Goal Categories
14. Life Below Water (OpenAlex)
Source: ORCID
Added: July 29, 2020

2020 journal article

New Gene Markers Involved in Molecular Processes of Tissue Repair, Response to Wounding and Regeneration Are Differently Expressed in Fibroblasts from Porcine Oral Mucosa during Long-Term Primary Culture

Animals.

By: A. Bryja*, P. Sujka-Kordowska*, A. Konwerska*, S. Ciesiółka*, M. Wieczorkiewicz*, D. Bukowska*, P. Antosik*, R. Bryl* ...

author keywords: primary culture; porcine; fibroblasts; microarray
TL;DR: Following the analysis of gene expression in three previously identified groups of genes, it is identified that transforming growth factor beta 1, ITGB3, PDPN, and ETS1 are involved in all three processes, suggesting that these genes could be recognized as markers of repair specific for oral fibroblasts within the porcine mucosal tissue. (via Semantic Scholar)
Source: ORCID
Added: October 27, 2020

2020 journal article

Photobiomodulation—Underlying Mechanism and Clinical Applications

Journal of Clinical Medicine.

author keywords: laser; low-level laser therapy; photobiomodulation; stem cells; tissue regeneration
TL;DR: The purpose of this study is to explore the possibilities for the application of laser therapy in medicine and dentistry by analyzing lasers’ underlying mechanism of action on different cells, with a special focus on stem cells and mechanisms of repair. (via Semantic Scholar)
Source: ORCID
Added: June 8, 2020

2020 journal article

Placental Lactogen as a Marker of Maternal Obesity, Diabetes, and Fetal Growth Abnormalities: Current Knowledge and Clinical Perspectives

Journal of Clinical Medicine.

author keywords: diabetes; fetal growth; placental lactogen; obesity
TL;DR: PL concentration measurement could be useful in the prediction of fetal macrosomia in women with normal oral glucose tolerance test (OGTT) results or in evaluating the risk of fetal growth restriction, but its application in standard clinical practice seems to be limited in the era of ultrasonography. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (Web of Science; OpenAlex)
5. Gender Equality (Web of Science)
Source: ORCID
Added: April 21, 2020

2020 journal article

Skeletal Muscle and the Effects of Ammonia Toxicity in Fish, Mammalian, and Avian Species: A Comparative Review Based on Molecular Research

International Journal of Molecular Sciences, 21(13), 4641.

By: E. Miramontes n, . mozdziak n, J. Petitte n, M. Kulus*, M. Wieczorkiewicz* & B. Kempisty*

author keywords: muscle; fish; avian; mammal; ammonia; myostatin
MeSH headings : Ammonia / pharmacology; Ammonia / toxicity; Animals; Birds; Fishes; Hyperammonemia / etiology; Liver Cirrhosis / etiology; Mammals; Muscle Development / drug effects; Muscle Development / physiology; Muscle Fibers, Skeletal / drug effects; Muscle, Skeletal / drug effects; Muscle, Skeletal / metabolism; Muscular Atrophy / metabolism; Muscular Atrophy / physiopathology; Sarcopenia / etiology
TL;DR: Understanding the differences between fish, mammalian and avian species’ myogenic response to hyperammonemia could lead to new therapies for muscle wasting due to a greater understanding of the mechanisms behind skeletal muscle regulation and how ammonia effects these mechanisms. (via Semantic Scholar)
UN Sustainable Development Goal Categories
2. Zero Hunger (OpenAlex)
14. Life Below Water (Web of Science)
Source: ORCID
Added: July 5, 2020

2020 journal article

Stemness Potency of Human Gingival Cells—Application in Anticancer Therapies and Clinical Trials

Cells.

author keywords: gingiva; gingival mesenchymal stem cells; mesenchymal stem cells; mesenchymal stromal cells; cancer; exosomes
MeSH headings : Animals; Carcinoma, Squamous Cell / therapy; Cell Culture Techniques; Cell Differentiation; Clinical Trials as Topic; Exosomes / metabolism; Gingiva / cytology; Gingiva / metabolism; Humans; Mesenchymal Stem Cell Transplantation / methods; Mesenchymal Stem Cells / immunology; Mesenchymal Stem Cells / metabolism; Mice; Tongue Neoplasms / therapy
TL;DR: Gingivae, as the part of periodontium, are involved in tooth support and possess the ability to heal rapidly, without scar formation, and GMSCs promise to be a valuable tool in cancer treatment, especially in tongue squamous cell carcinoma with the use of targeted therapy. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (Web of Science; OpenAlex)
Source: ORCID
Added: August 23, 2020

2020 review

The Proliferation and Differentiation of Adipose-Derived Stem Cells in Neovascularization and Angiogenesis

[Review of ]. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, 21(11).

By: G. Hutchings*, K. Janowicz*, L. Moncrieff*, C. Dompe*, E. Strauss*, I. Kocherova*, M. Nawrocki*, L. Kruszyna* ...

author keywords: adipose; stem; differentiation; vascularization; angiogenesis
MeSH headings : Adipose Tissue / cytology; Animals; Cell Differentiation; Cell Proliferation; Humans; Mesenchymal Stem Cells / cytology; Mesenchymal Stem Cells / metabolism; Mesenchymal Stem Cells / physiology; Neovascularization, Physiologic
TL;DR: This review aims to investigate the link between ASCs and angiogenesis/neovascularization, with references to current studies, and describes the molecular mechanisms of these processes, as well as ASC differentiation and proliferation. (via Semantic Scholar)
Sources: Web Of Science, NC State University Libraries, ORCID
Added: July 20, 2020

2020 journal article

The Role of the Adipokines in the Most Common Gestational Complications

International Journal of Molecular Sciences.

author keywords: adiponectin; apelin; chemerin; gestational diabetes; irisin; leptin; omentin; preeclampsia; resistin; visfatin
MeSH headings : Adipokines / metabolism; Animals; Biomarkers / metabolism; Diabetes, Gestational / metabolism; Diabetes, Gestational / pathology; Female; Humans; Pre-Eclampsia / metabolism; Pre-Eclampsia / pathology; Pregnancy
TL;DR: Routine assessments of adipokine levels during pregnancy are not recommended in the management of both normal and complicated pregnancies, and future implementation of obesity and their receptors as new therapeutic targets appears promising but requires further validation in humans. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (Web of Science; OpenAlex)
Source: ORCID
Added: December 15, 2020

2020 journal article

The Stemness of Human Ovarian Granulosa Cells and the Role of Resveratrol in the Differentiation of MSCs—A Review Based on Cellular and Molecular Knowledge

Cells.

author keywords: mesenchymal stem cells; granulosa cells; differentiation; resveratrol; SIRT1
MeSH headings : Animals; Cell Differentiation / drug effects; Female; Granulosa Cells / cytology; Granulosa Cells / drug effects; Granulosa Cells / metabolism; Humans; Mesenchymal Stem Cells / cytology; Models, Biological; Resveratrol / chemistry; Resveratrol / pharmacology; Signal Transduction / drug effects
TL;DR: The current knowledge about granulosa stem cells, the signaling pathways driving their development and maturation, as well as biological activities of resveratrol and its properties as a pro-differentiation agent are reviewed. (via Semantic Scholar)
Source: ORCID
Added: June 12, 2020

2020 journal article

The processes of cellular growth, aging, and programmed cell death are involved in lifespan of ovarian granulosa cells during short-term IVC - Study based on animal model

THERIOGENOLOGY, 148, 76–88.

By: M. Kulus*, W. Kranc*, P. Sujka-Kordowska*, P. Mozdziak n, M. Jankowski*, A. Konwerska*, J. Kulus*, D. Bukowska* ...

author keywords: Pig; Ovarian follicle; Granulosa cells; Primary culture; Microarray
MeSH headings : Animals; Apoptosis / physiology; Cell Survival / physiology; Cells, Cultured; Down-Regulation; Female; Gene Expression Regulation / physiology; Granulosa Cells / physiology; Protein Array Analysis; Swine; Transcriptome; Up-Regulation
TL;DR: The purpose of this study was to analyze gene expression in porcine GCs, to define differentially expressed genes belongs to the "cell growth", "aging", "positive regulation of cell death", "apoptotic process", "regulation of cellDeath", "cell death" and "negative regulation of Cell death" ontology groups during the short - term primary in vitro culture. (via Semantic Scholar)
Sources: Web Of Science, NC State University Libraries
Added: May 8, 2020

2020 journal article

Transcriptomic analysis of expression of genes regulating cell cycle progression in porcine ovarian granulosa cells during short-term in vitro primary culture

HISTOCHEMISTRY AND CELL BIOLOGY, 153(6), 397–412.

By: M. Kulus*, W. Kranc*, P. Sujka-Kordowska*, P. Celichowski*, A. Konwerska*, MaurycyJankowski, M. Jeseta*, M. Skowronski* ...

author keywords: Pig; Ovarian follicle; Granulosa cells; Primary culture; Microarray
MeSH headings : Animals; Cell Cycle / genetics; Cells, Cultured; Female; Gene Expression Profiling; Granulosa Cells / cytology; Ovarian Follicle / cytology; Swine; Transcriptome
TL;DR: The data obtained provide a potential reference for studies on the process of mammalian folliculogenesis, as well as suggests possible new genetic markers for cell cycle progress in in vitro cultured porcine granulosa cells. (via Semantic Scholar)
Sources: Web Of Science, NC State University Libraries
Added: July 6, 2020

2020 article

Transgenic chicken/poultry birds: serving us for survival

GENOMICS AND BIOTECHNOLOGICAL ADVANCES IN VETERINARY, POULTRY, AND FISHERIES, pp. 211–221.

By: A. Golkar-Narenji n, J. Petitte n & P. Mozdziak n

TL;DR: Development of transgenic technology in poultry science possibly helps to improve the efficiency of poultry industry productions and it may cause the development of different branches of avian industry with novel productions. (via Semantic Scholar)
Sources: Web Of Science, NC State University Libraries
Added: March 23, 2020

2019 journal article

Ammonia Induces a Myostatin-Mediated Atrophy in Mammalian Myotubes, but Induces Hypertrophy in Avian Myotubes

Frontiers in Sustainable Food Systems.

Paul Mozdziak

author keywords: muscle; ammonia; cirrhosis; sarcopenia; myostatin; glutamine; fiber type; myotubes
TL;DR: It is demonstrated that chicken myot tubes respond positively to ammonia while rodent myotubes respond negatively, and there is evidence that ammonia induces a fast fiber type shift in avian muscle, but a slow phenotype shift in mammalian muscle. (via Semantic Scholar)
Source: ORCID
Added: January 2, 2020

2019 journal article

Application potential and plasticity of human stem cells

Medical Journal of Cell Biology.

Paul Mozdziak

TL;DR: Progress in research on the use of stem cells in the treatment of heart attacks, burns, bone injuries and the use in animal models as an attempt to treat multiple sclerosis has been described, and the development of preclinical studies using Dental Pulp Stem Cells in various diseases such as Parkinson’s disease or Alzheimer's disease was paid. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (OpenAlex)
Source: ORCID
Added: January 2, 2020

2019 journal article

Biochemical properties of cofactor and coenzyme metabolism in porcine oviductal epithelial cells – a microarray study

Medical Journal of Cell Biology.

Paul Mozdziak

TL;DR: It can be concluded that changes observed on the 7th, 15th and 30th day of culture may indicate the increased metabolic and proliferation activity of studied cells in primary in vitro culture. (via Semantic Scholar)
Source: ORCID
Added: January 2, 2020

2019 journal article

Cardiac Stem Cell Therapy, Resident Progenitor Cells and the role of Cellular Signalling; a Review

Medical Journal of Cell Biology.

Paul Mozdziak

TL;DR: An overview of current studies and findings related to the potential of differentiation of CPCs to form mature cardiomyocytes (CM) and thereby heal damaged myocardial tissue, as well as implications of these findings for further research areas and possible treatments, are offered. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (OpenAlex)
Source: ORCID
Added: January 2, 2020

2019 journal article

Coenzyme and cofactor metabolism belongs to biochemical processes significantly regulated in human granulosa cells collected after IVF during long-term primary in vitro culture

Medical Journal of Cell Biology.

Paul Mozdziak

TL;DR: Granulosa cells provide the microenvironment necessary for the development of the follicle and the maturation of the oocyte, and the significant plasticity of this cell population is indicated, suggesting that GCs can undergo a transdifferentiation process. (via Semantic Scholar)
Source: ORCID
Added: January 2, 2020

2019 journal article

Current clinical applications of adipose-derived stem cells in humans and animals

Medical Journal of Cell Biology.

Paul Mozdziak

TL;DR: Adipose derived stem cells are a type of mesenchymal stem cell that, because of their straightforward isolation procedure and ready availability, have been intensively studied in the recent years regarding their possible clinical applications. (via Semantic Scholar)
Source: ORCID
Added: January 2, 2020

2019 review

Differential ammonia metabolism and toxicity between avian and mammalian species, and effect of ammonia on skeletal muscle: A comparative review

[Review of ]. JOURNAL OF ANIMAL PHYSIOLOGY AND ANIMAL NUTRITION, 103(3), 774–785.

By: R. Stern n & P. Mozdziak n

author keywords: ammonia; avian; cirrhosis; liver; mammalian; muscle
MeSH headings : Ammonia / metabolism; Ammonia / toxicity; Animals; Mammals / metabolism; Muscle, Skeletal / drug effects; Poultry / metabolism; Species Specificity
TL;DR: Understanding the intrinsic physiological mechanisms that allow for ammonia to be utilized for growth has potential to reveal novel approaches to muscle growth in avian species and will provide new targets for preventing muscle degeneration in mammalian species. (via Semantic Scholar)
Sources: Web Of Science, NC State University Libraries
Added: June 4, 2019

2019 journal article

Evidence for existence of molecular stemness markers in porcine ovarian follicular granulosa cells

Medical Journal of Cell Biology.

Paul Mozdziak

TL;DR: The results confirm stemness potential of porcine GCs and provide an insight into the transcriptome changes during in vitro cultivation. (via Semantic Scholar)
Source: ORCID
Added: January 2, 2020

2019 journal article

Glutamine synthetase in avian muscle contributes to a positive myogenic response to ammonia compared with mammalian muscle

AMERICAN JOURNAL OF PHYSIOLOGY-REGULATORY INTEGRATIVE AND COMPARATIVE PHYSIOLOGY, 317(1), R214–R221.

By: R. Stern n & P. Mozdziak n

author keywords: ammonia; cirrhosis; glutamine; glutamine synthetase; muscle
MeSH headings : Acetates / pharmacology; Animals; Cell Line; Chick Embryo; Glutamate-Ammonia Ligase / metabolism; Glutamine / pharmacology; Humans; Myoblasts / drug effects; Myoblasts / physiology; Rats
TL;DR: Data support species differences in skeletal muscle ammonia metabolism and suggest that glutamine synthesis is a mechanism of ammonia utilization in avian muscle. (via Semantic Scholar)
UN Sustainable Development Goal Categories
2. Zero Hunger (Web of Science)
Sources: Web Of Science, NC State University Libraries
Added: August 5, 2019

2019 journal article

Human Dental Pulp Stem Cells: recent findings and current research

Medical Journal of Cell Biology.

Paul Mozdziak

TL;DR: New advances in the area of regenerative dentistry and regenerative medicine, including three dimensional printing and three dimensional analysis, emerged to deepen studies under procedures to replace the non patient specific artificial implants. (via Semantic Scholar)
Source: ORCID
Added: January 2, 2020

2019 journal article

Human Ovarian Granulosa Cells Isolated during an IVF Procedure Exhibit Differential Expression of Genes Regulating Cell Division and Mitotic Spindle Formation

Journal of Clinical Medicine.

author keywords: ovarian granulosa; human; in vitro; cell division
TL;DR: The obtained results suggest that long-term in vitro cultivation of GCs may lead to their differentiation toward another cell type, including cells with cancer-like characteristics. (via Semantic Scholar)
UN Sustainable Development Goal Categories
5. Gender Equality (Web of Science)
Source: ORCID
Added: January 2, 2020

2019 review

Human Umbilical Vein Endothelial Cells (HUVECs) Co-Culture with Osteogenic Cells: From Molecular Communication to Engineering Prevascularised Bone Grafts

[Review of ]. JOURNAL OF CLINICAL MEDICINE, 8(10).

By: I. Kocherova*, A. Bryja*, P. Mozdziak n, A. Volponi*, M. Dyszkiewicz-Konwinska*, H. Piotrowska-Kempisty*, P. Antosik*, D. Bukowska* ...

author keywords: human umbilical vein endothelial cells; mesenchymal stem cells; osteoblasts; co-culture; prevascularization
TL;DR: The present review focuses on the best-characterized endothelial cells—HUVECs—attempting to estimate whether the co-culture approach, using these cells, could bring us closer to development and possible clinical application of prevascularized bone grafts. (via Semantic Scholar)
Sources: Web Of Science, ORCID, NC State University Libraries
Added: December 9, 2019

2019 journal article

Nucleotide, ribonucleotide and ribonucleoside binding belongs to differentially expressed genes in porcine epithelial oviductal cells during longterm primary cultivation

Medical Journal of Cell Biology.

Paul Mozdziak

TL;DR: Nucleotide, ribonucleotide and nucleoside binding patterns at a molecular level in oviduct epithelial cells (OECs) are described and special attention was paid to those showing the greatest variability in relation to the reference measurement, including OASL, PIM1, ACTA2 and ABCA1. (via Semantic Scholar)
Source: ORCID
Added: January 2, 2020

2019 journal article

Ovarian follicular cells - living in the shadow of stemness cellular competence

Medical Journal of Cell Biology.

Paul Mozdziak

TL;DR: Both three-dimensional culturing and mouse embryonic fibroblast medium have been used to help improve the culturing lifespan of GCs so that their profound proliferation and differentiation capabilities can be studied. (via Semantic Scholar)
Source: ORCID
Added: January 2, 2020

2019 journal article

The in vitro effect of chick embryo extract on mice pre-antral follicles

VETERINARY RESEARCH FORUM, 10(3), 213–219.

By: H. Torkashvand*, R. Fathi*, A. Shahverdi*, A. Golkar*, P. Mozdziak n & H. Eimani*

author keywords: Chick embryo extract; Follicle; Granulosa cells; In vitro culture
TL;DR: The increasing effect of CEE on follicle viability with keeping normal gene expression indicates that addition of proper percentage of Cee to culture media improves culture conditions, making it a possible choice to be used as a follicular growth enhancer in infertility clinics. (via Semantic Scholar)
UN Sustainable Development Goal Categories
5. Gender Equality (Web of Science)
Sources: Web Of Science, NC State University Libraries
Added: February 17, 2020

2018 journal article

Characterization of TTN Novex Splicing Variants across Species and the Role of RBM20 in Novex-Specific Exon Splicing

GENES, 9(2).

By: Z. Chen*, J. Song*, L. Chen*, C. Zhu*, H. Cai*, M. Sun*, A. Stern n, P. Mozdziak n ...

Contributors: Z. Chen*, J. Song*, L. Chen*, C. Zhu*, H. Cai*, M. Sun*, A. Stern n, P. Mozdziak n ...

author keywords: TTN; RBM20; Novex isoforms; cardiomyopathy; alternative splicing
TL;DR: The expression levels of Novex variants in human hearts with cardiomyopathies suggested that Novexes 2 and 3 could be associated with dilatedCardiomyopathy (DCM) and/or arrhythmogenic right ventricular cardiomeopathy (ARVC). (via Semantic Scholar)
UN Sustainable Development Goal Categories
15. Life on Land (OpenAlex)
Sources: Web Of Science, ORCID, NC State University Libraries
Added: August 6, 2018

2018 journal article

Cloning of japanese quail (Coturnix japonica) follistatin and production of bioactive quail follistatin288 in escherichia coli

International Journal of Poultry Science, 17(1), 8–21.

By: Y. Maaeni*, S. Lee*, D. Choi n, P. Mozdziak & Y. Kim n

Contributors: Y. Maaeni*, S. Lee*, D. Choi n, P. Mozdziak & Y. Kim n

UN Sustainable Development Goal Categories
2. Zero Hunger (OpenAlex)
Source: ORCID
Added: January 2, 2020

2018 journal article

Important signals regulating coronary artery angiogenesis

MICROVASCULAR RESEARCH, 117, 1–9.

By: S. Shoeibi*, P. Mozdziak n & S. Mohammadi*

Contributors: S. Shoeibi*, P. Mozdziak n & S. Mohammadi*

author keywords: Angiogenesis; Growth factor; Intraplaque
MeSH headings : Angiogenesis Inhibitors / therapeutic use; Angiogenic Proteins / metabolism; Animals; Cell Communication; Cell Differentiation; Cell Movement; Cell Proliferation; Coronary Artery Disease / drug therapy; Coronary Artery Disease / metabolism; Coronary Artery Disease / pathology; Coronary Artery Disease / physiopathology; Coronary Vessels / drug effects; Coronary Vessels / metabolism; Coronary Vessels / pathology; Coronary Vessels / physiopathology; Humans; Neovascularization, Pathologic; Plaque, Atherosclerotic; Signal Transduction
TL;DR: Since VEGF has a key role during angiogenesis; it may be considered as a good therapeutic target in the clinic and the essential function of several angiogenic factors involved in coronaryAngiogenesis and intraplaque ang iogenesis in atherosclerosis are carefully considered along with the use of angiogens factors in clinical practice. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Sources: Web Of Science, ORCID, NC State University Libraries
Added: August 6, 2018

2018 journal article

The method of chicken whole embryo culture using the eggshell windowing, surrogate eggshell and ex ovo culture system

BRITISH POULTRY SCIENCE, 59(2), 240–244.

By: M. Farzaneh*, F. Attari*, S. Khoshnam* & P. Mozdziak n

author keywords: Chicken embryo; efficient technique; eggshell; gene manipulation; in vivo study
MeSH headings : Animal Husbandry / methods; Animals; Chick Embryo / growth & development; Chick Embryo / physiology; Chickens; Developmental Biology / methods; Egg Shell
TL;DR: This short review illustrates recent applications of well-designed whole embryo culture systems as a robust model for research into numerous biological mechanism, drug discovery, gene manipulating and production of functional proteins. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018

2018 journal article

Z-band and M-band titin splicing and regulation by RNA binding motif 20 in striated muscles

JOURNAL OF CELLULAR BIOCHEMISTRY, 119(12), 9986–9996.

By: Z. Chen*, R. Maimaiti*, C. Zhu*, H. Cai*, A. Stern n, P. Mozdziak n, Y. Ge*, S. Ford*, P. Nathanielsz*, W. Guo*

author keywords: alternative splicing; heart disease; M-band; RNA binding motif 20 (RBM20); titin (TTN); Z-band
MeSH headings : Alternative Splicing; Animals; Connectin / genetics; Connectin / metabolism; Humans; Mice; Muscle, Skeletal / metabolism; Myocardium / metabolism; Protein Kinases / genetics; Protein Kinases / metabolism; RNA Splice Sites; RNA, Messenger / genetics; RNA, Messenger / metabolism; RNA-Binding Proteins / metabolism; Rats; Sarcomeres / metabolism; Sheep / genetics; Sheep / metabolism
TL;DR: It is revealed that RBM20 does not regulate the Z‐ and M‐band splicing in the heart, but does in skeletal muscles, and the first evidence of the role of R BM20 is provided in the Z- and M-band TTN splicing. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Sources: Web Of Science, NC State University Libraries
Added: December 3, 2018

2017 journal article

Ammonia elicits a different myogenic response in avian and murine myotubes

IN VITRO CELLULAR & DEVELOPMENTAL BIOLOGY-ANIMAL, 53(2), 99–110.

By: R. Stern n, S. Dasarathy* & P. Mozdziak n

Contributors: R. Stern n, S. Dasarathy* & P. Mozdziak n

author keywords: Muscle; Myogenesis; Myoblast; Liver; Cirrhosis
MeSH headings : Acetates / pharmacology; Ammonia / pharmacology; Animals; Blotting, Western; Cell Survival / drug effects; Chick Embryo; Gene Expression Regulation / drug effects; Hepatocytes / drug effects; Hepatocytes / metabolism; Mice; Muscle Development / drug effects; Muscle Fibers, Skeletal / cytology; Muscle Fibers, Skeletal / drug effects; Muscle Fibers, Skeletal / physiology; Myostatin / metabolism; Real-Time Polymerase Chain Reaction
TL;DR: Overall, it appears that there is a positive myogenic response to hyperammonemia in avian myotube compared to murine myotubes, which supports a proliferative myogenic environment. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Sources: Web Of Science, ORCID, NC State University Libraries
Added: August 6, 2018

2017 journal article

An in vitro study on oocyte and follicles of transplanted ovaries treated with vascular endothelial growth factor

JOURNAL OF THE TURKISH-GERMAN GYNECOLOGICAL ASSOCIATION, 18(4), 167–173.

By: M. Zand-Vakili*, A. Golkar-Narenji*, P. Mozdziak n & H. Eimani*

Contributors: M. Zand-Vakili*, A. Golkar-Narenji*, P. Mozdziak n & H. Eimani*

author keywords: Follicle; oocyte; ovary; transplantation; vascular endothelial growth factor
TL;DR: The improving effect of V EGF on in vitro maturation and in vitro development outcome indicates that VEGF administration may increase transplantation efficiency for fertility preservation. (via Semantic Scholar)
UN Sustainable Development Goal Categories
5. Gender Equality (Web of Science)
Sources: Web Of Science, ORCID, NC State University Libraries
Added: August 6, 2018

2017 journal article

Avian embryos and related cell lines: A convenient platform for recombinant proteins and vaccine production

Biotechnology Journal, 12(5), 1600598.

Contributors: M. Farzaneh*, S. Hassani*, P. Mozdziak* & H. Baharvand*

author keywords: Avian; Pluripotent cell lines; Recombinant proteins; Transgenic chicken; Vaccine
MeSH headings : Animals; Animals, Genetically Modified; Cell Line; Chick Embryo; Chickens; Humans; Pluripotent Stem Cells; Recombinant Proteins; Viral Vaccines
TL;DR: The unique characteristics of avian eggs in terms of safety, large scale and economical production of recombinant proteins, and the currently available germ cell‐mediated gene transfer system provides a more efficient strategy in gene targeting and creation of transgenic birds. (via Semantic Scholar)
Sources: ORCID, Crossref, NC State University Libraries
Added: January 2, 2020

2017 review

Biogenesis of Selenium Nanoparticles Using Green Chemistry

[Review of ]. TOPICS IN CURRENT CHEMISTRY, 375(6).

By: S. Shoeibi*, P. Mozdziak n & A. Golkar-Narenji*

Contributors: S. Shoeibi*, P. Mozdziak n & A. Golkar-Narenji*

author keywords: SeNps; Green chemistry; Reduction; Applications; Antimicrobial
MeSH headings : Bacteria / chemistry; Bacteria / metabolism; Fungi / chemistry; Fungi / metabolism; Metal Nanoparticles / chemistry; Plants / chemistry; Plants / metabolism; Selenium / chemistry; Selenium / metabolism
UN Sustainable Development Goal Categories
Sources: Web Of Science, ORCID, NC State University Libraries
Added: August 6, 2018

2017 journal article

Chemoprevention of spontaneous ovarian cancer in the domestic hen

Poultry Science, 96(6), 1901–1909.

By: E. Mocka n, R. Stern n, O. Fletcher n, K. Anderson n, J. Petitte n & P. Mozdziak n

author keywords: avian; CP-31398; oviduct; ovarian; cancer
MeSH headings : Adenocarcinoma / prevention & control; Adenocarcinoma / veterinary; Animal Feed / analysis; Animals; Chemoprevention / veterinary; Chickens; Diet / veterinary; Female; Genes, p53 / drug effects; Genital Neoplasms, Female / prevention & control; Genital Neoplasms, Female / veterinary; Ovarian Neoplasms / prevention & control; Ovarian Neoplasms / veterinary; Oviducts / pathology; Oviposition; Pyrimidines / administration & dosage; Pyrimidines / pharmacology
TL;DR: CP‐31398 appears to be an effective tool for chemoprevention against ovarian malignancy, but does not appear to affect oviductal malignancies. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (Web of Science; OpenAlex)
Sources: Web Of Science, NC State University Libraries, Crossref, ORCID
Added: August 6, 2018

2017 review

Satellite cells contribution to exercise mediated muscle hypertrophy and repair

[Review of ]. Cell Journal, 18(4), 473–484.

By: B. Bazgir, R. Fathi, M. Valojerdi, P. Mozdziak & A. Asgari

Source: NC State University Libraries
Added: August 6, 2018

2017 review

The evolution of chicken stem cell culture methods

[Review of ]. BRITISH POULTRY SCIENCE, 58(6), 681–686.

By: M. Farzaneh*, F. Attari*, P. Mozdziak n & S. Khoshnam*

Contributors: M. Farzaneh*, F. Attari*, P. Mozdziak n & S. Khoshnam*

author keywords: Chicken embryo; defined culture medium; stem cells; suspension culture; vaccine manufacture
MeSH headings : Animals; Cell Culture Techniques / methods; Cell Differentiation; Chickens; Embryonic Stem Cells / metabolism; Germ Cells / metabolism; Induced Pluripotent Stem Cells / metabolism
TL;DR: Development of a suspension cell culture process for chicken embryonic stem cells, chicken primordial germ cells (PGCs) and chicken induced pluripotent stem cells (ciPSCs) will be an important advance for increasing the growth kinetics of these cells. (via Semantic Scholar)
UN Sustainable Development Goal Categories
8. Decent Work and Economic Growth (OpenAlex)
Sources: Web Of Science, ORCID, NC State University Libraries
Added: August 6, 2018

2016 journal article

Histological evaluation of the effect of VEGF on auto-transplanted mouse ovaries

ANIMAL CELLS AND SYSTEMS, 20(5), 260–266.

By: M. Zand-vakili*, H. Eimani*, A. Golkar-Narenji*, P. Eftekhari-Yazdi*, A. Shahverdi* & P. Mozdziak n

Contributors: M. Zand-vakili*, H. Eimani*, A. Golkar-Narenji*, P. Eftekhari-Yazdi*, A. Shahverdi* & P. Mozdziak n

author keywords: Histology; ovary; vascularization; VEGF
TL;DR: Survival rate of follicles and follicular development has improved with the effect of VEGF and the most effective dosage of V EGF on transplanted tissue was determined over H&E (hematoxylin and eosin) staining results. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (Web of Science; OpenAlex)
5. Gender Equality (Web of Science)
Sources: Web Of Science, ORCID, NC State University Libraries
Added: August 6, 2018

2016 journal article

Satellite cells contribution to exercise mediated muscle hypertrophy and repair

Cell Journal, 18(4), 473–484. http://www.scopus.com/inward/record.url?eid=2-s2.0-84992348114&partnerID=MN8TOARS

By: B. Bazgir, R. Fathi, M. Valojerdi, P. Mozdziak & A. Asgari

Contributors: B. Bazgir, R. Fathi, M. Valojerdi, P. Mozdziak & A. Asgari

Source: ORCID
Added: January 2, 2020

2015 journal article

The effect of hyperammonemia on myostatin and myogenic regulatory factor gene expression in broiler embryos

ANIMAL, 9(6), 992–999.

By: R. Stern n, C. Ashwell n, S. Dasarathy* & P. Mozdziak n

Contributors: R. Stern n, C. Ashwell n, S. Dasarathy* & P. Mozdziak n

author keywords: broiler; hyperammonemia; myogenesis; myogenic regulatory factor; myostatin
MeSH headings : Animals; Chick Embryo; Chickens; Gene Expression Regulation; Hyperammonemia / genetics; Hyperammonemia / metabolism; Hyperammonemia / veterinary; Muscle Development / genetics; Myogenic Regulatory Factors / genetics; Myogenic Regulatory Factors / metabolism; Myogenin / genetics; Myogenin / metabolism; Pectoralis Muscles / metabolism; Poultry Diseases / genetics; Poultry Diseases / metabolism; RNA, Messenger / genetics; RNA, Messenger / metabolism
TL;DR: Overall, it appears possible to inhibit myostatin expression through hyperammonemia, which is expected to have a positive effect on embryonic myogenesis and postnatal muscle growth. (via Semantic Scholar)
Sources: Web Of Science, ORCID, NC State University Libraries
Added: August 6, 2018

2014 journal article

Epithelial Cell Tumors of the Hen Reproductive Tract

Avian Diseases, 58(1), 95–101.

By: E. Harris n, O. Fletcher*, K. Anderson n, J. Petitte n, L. Kopelovich* & P. Mozdziak n

Contributors: E. Harris n, O. Fletcher*, K. Anderson n, J. Petitte n, L. Kopelovich* & P. Mozdziak n

author keywords: hen; egg-laying; cancer; oviductal; ovarian; malignancy
MeSH headings : Animals; Chickens; Epithelial Cells / pathology; Female; Gastrointestinal Neoplasms / classification; Gastrointestinal Neoplasms / epidemiology; Gastrointestinal Neoplasms / pathology; Gastrointestinal Neoplasms / veterinary; Genital Diseases, Female / classification; Genital Diseases, Female / epidemiology; Genital Diseases, Female / pathology; Genital Diseases, Female / veterinary; Incidence; Ovarian Neoplasms / classification; Ovarian Neoplasms / epidemiology; Ovarian Neoplasms / pathology; Ovarian Neoplasms / veterinary; Oviducts / pathology; Poultry Diseases / classification; Poultry Diseases / epidemiology; Poultry Diseases / pathology
TL;DR: The egg-laying hen appears to be the most promising model to study the spontaneous occurrence of ovarian tumors in the clinical setting and an updated gross pathology and histologic classification systems for the hen reproductive malignancies provides a method to report the range of reproductive tumors revealed in a flock of aged laying hens. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (Web of Science; OpenAlex)
Sources: Web Of Science, ORCID, NC State University Libraries
Added: August 6, 2018

2014 book

Poultry

In Encyclopedia of Meat Sciences (pp. 369–373).

By: P. Mozdziak n

Contributors: P. Mozdziak n

TL;DR: The historical production, present production, and nutritional value of the predominant poultry meat species (chicken and turkeys), and poultry species that have a much smaller presence in the marketplace are reviewed. (via Semantic Scholar)
UN Sustainable Development Goal Categories
2. Zero Hunger (OpenAlex)
Source: ORCID
Added: January 2, 2020

2014 book

Production of Transgenic Poultry

In Transgenic Animal Technology: A Laboratory Handbook: Third Edition (pp. 335–357).

By: J. Petitte n & P. Mozdziak n

Contributors: J. Petitte n & P. Mozdziak n

TL;DR: The domestic laying hen is being viewed as dual-purpose research animal with other applications in developmental biology, biomedicine, and biomanufacturing, meaning transgenic technology in poultry can influence entirely new industries outside of agriculture. (via Semantic Scholar)
UN Sustainable Development Goal Categories
2. Zero Hunger (OpenAlex)
Source: ORCID
Added: January 2, 2020

2013 journal article

Hyperammonemia in cirrhosis induces transcriptional regulation of myostatin by an NF-kappa B-mediated mechanism

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 110(45), 18162–18167.

By: J. Qiu, S. Thapaliya, A. Runkana*, Y. Yang, C. Tsien, M. Mohan*, A. Narayanan, B. Eghtesad ...

Contributors: J. Qiu, S. Thapaliya, A. Runkana*, Y. Yang, C. Tsien, M. Mohan*, A. Narayanan, B. Eghtesad ...

author keywords: signaling; portosystemic shunting
MeSH headings : Acetates; Animals; Chromatin Immunoprecipitation; Electrophoretic Mobility Shift Assay; Gene Expression Regulation / physiology; Humans; Hyperammonemia / etiology; Hyperammonemia / physiopathology; Immunoblotting; Liver Cirrhosis / complications; Mice; Mice, Knockout; Microscopy, Confocal; Muscle Fibers, Skeletal / metabolism; Myostatin / genetics; Myostatin / metabolism; NF-kappa B / metabolism; Real-Time Polymerase Chain Reaction
TL;DR: It is shown that the expression of myostatin, a negative regulator of skeletal muscle mass, is increased in the cirrhotic muscle and is mediated by increased ammonia concentration, and a mechanism by which sarcopenia develops in cirrhosis patients is suggested. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (Web of Science; OpenAlex)
Sources: Web Of Science, ORCID, NC State University Libraries
Added: August 6, 2018

2012 journal article

Differential expression of genes characterizing myofibre phenotype

ANIMAL GENETICS, 43(3), 298–308.

By: L. Nierobisz n, K. Sporer*, G. Strasburg*, K. Reed, S. Velleman*, C. Ashwell n, J. Felts n, P. Mozdziak n

Contributors: L. Nierobisz n, K. Sporer*, G. Strasburg*, K. Reed, S. Velleman*, C. Ashwell n, J. Felts n, P. Mozdziak n

author keywords: gene expression; microarray; muscle phenotype; turkey
MeSH headings : Age Factors; Animals; DNA, Complementary / genetics; Gene Expression Profiling; Gene Expression Regulation; Male; Meat; Muscle Fibers, Skeletal / metabolism; Muscle Proteins / genetics; Muscle Proteins / metabolism; Oligonucleotide Array Sequence Analysis; Phenotype; Real-Time Polymerase Chain Reaction; Turkeys / genetics; Turkeys / growth & development; Turkeys / metabolism
TL;DR: The gene analysis revealed that phenotypically 'red' BF muscle has high expression of glycolytic genes usually associated with the 'white' muscle phenotype, which may have large implications in muscle-type-related disorders and improvement of muscle quality in agricultural species. (via Semantic Scholar)
UN Sustainable Development Goal Categories
2. Zero Hunger (OpenAlex)
Sources: Web Of Science, ORCID, NC State University Libraries
Added: August 6, 2018

2012 book

Production of Transgenic Poultry

In Transgenic Animal Technology: A Laboratory Handbook: Second Edition (pp. 279–306).

By: J. Petitte & P. Mozdziak*

Contributors: J. Petitte & P. Mozdziak*

UN Sustainable Development Goal Categories
2. Zero Hunger (OpenAlex)
Source: ORCID
Added: January 2, 2020

2011 journal article

MitoQ(10) induces adipogenesis and oxidative metabolism in myotube cultures

COMPARATIVE BIOCHEMISTRY AND PHYSIOLOGY B-BIOCHEMISTRY & MOLECULAR BIOLOGY, 158(2), 125–131.

By: L. Nierobisz*, D. McFarland & P. Mozdziak*

Contributors: L. Nierobisz*, D. McFarland & P. Mozdziak*

author keywords: MitoQ(10); PGC-1 alpha; PPAR gamma; Adipocytes; Skeletal muscle; Avian
MeSH headings : Adipogenesis / drug effects; Animals; Cells, Cultured; Lipids / biosynthesis; Muscle Fibers, Skeletal / drug effects; Muscle Fibers, Skeletal / metabolism; Organophosphorus Compounds / pharmacology; Oxidation-Reduction; PPAR gamma / biosynthesis; Turkeys; Ubiquinone / pharmacology
TL;DR: MitoQ(10) likely controls a range of metabolic pathways through its differential regulation of gene expression levels in myotubes derived from fast-glycolytic and slow-oxidative muscles through its up-regulation of oxidative mitochondrial biogenesis and adipogenesis in PM myotube cultures. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Sources: Web Of Science, ORCID, NC State University Libraries
Added: August 6, 2018

2010 journal article

Fiber Phenotype and Coenzyme Q(10) Content in Turkey Skeletal Muscles

CELLS TISSUES ORGANS, 192(6), 382–394.

By: L. Nierobisz n, N. Hentz n, J. Felts n & P. Mozdziak*

Contributors: L. Nierobisz n, N. Hentz n, J. Felts n & P. Mozdziak*

author keywords: Coenzyme Q(10); Mitochondria; Muscle metabolism; Muscle phenotype; Turkey
MeSH headings : Animals; Blotting, Western; Chromatography, High Pressure Liquid; Immunohistochemistry; Muscle Fibers, Skeletal / classification; Muscle Fibers, Skeletal / metabolism; Muscle, Skeletal / metabolism; Myosins / metabolism; Succinate Dehydrogenase / metabolism; Turkeys / metabolism; Ubiquinone / analogs & derivatives; Ubiquinone / metabolism
TL;DR: Age-related decreases in mitochondrial CoQ10 content in muscles with fast/glycolytic profile are revealed, and it is demonstrated that muscles with a slow/oxidative phenotypic profile contain a higher proportion of Co Q10 than muscles withA fast/ Glycolysis phenotypesic profile. (via Semantic Scholar)
UN Sustainable Development Goal Categories
7. Affordable and Clean Energy (OpenAlex)
Sources: Web Of Science, ORCID, NC State University Libraries
Added: August 6, 2018

2010 journal article

Measuring the intra-individual variability of the plasma proteome in the chicken model of spontaneous ovarian adenocarcinoma

ANALYTICAL AND BIOANALYTICAL CHEMISTRY, 398(2), 737–749.

By: A. Hawkridge n, R. Wysocky n, J. Petitte n, K. Anderson n, P. Mozdziak n, O. Fletcher n, J. Horowitz n, D. Muddiman n

Contributors: A. Hawkridge n, R. Wysocky n, J. Petitte n, K. Anderson n, P. Mozdziak n, O. Fletcher n, J. Horowitz n, D. Muddiman n

author keywords: Genomics/proteomics; Mass spectrometry/ICP-MS; Biological samples; Bioanalytical methods; Clinical/biomedical analysis
MeSH headings : Adenocarcinoma / metabolism; Adenocarcinoma / pathology; Animals; Chickens; Female; Humans; Mass Spectrometry / methods; Ovarian Neoplasms / metabolism; Ovarian Neoplasms / pathology; Plasma / metabolism; Proteome / analysis; Proteome / metabolism; Proteomics / methods
TL;DR: An experimental strategy for biomarker discovery is reported herein that combines the chicken model of EOC, longitudinal plasma sample collection with matched tissues, advanced mass spectrometry-based proteomics, and concepts derived from the index of individuality in an effort to identify diagnostic protein biomarkers. (via Semantic Scholar)
Sources: Web Of Science, ORCID, NC State University Libraries
Added: August 6, 2018

2010 article

Measuring the intra-individual variability of the plasma proteome in the chicken model of spontaneous ovarian adenocarcinoma (vol 398, pg 737, 2010)

Hawkridge, A. M., Wysocky, R. B., Petitte, J. N., Anderson, K. E., Mozdziak, P. E., Fletcher, O. J., … Muddiman, D. C. (2010, October). ANALYTICAL AND BIOANALYTICAL CHEMISTRY, Vol. 398, pp. 1835–1835.

By: A. Hawkridge n, R. Wysocky n, J. Petitte n, K. Anderson n, P. Mozdziak n, O. Fletcher n, J. Horowitz n, D. Muddiman n

Contributors: A. Hawkridge n, R. Wysocky n, J. Petitte n, K. Anderson n, P. Mozdziak n, O. Fletcher n, J. Horowitz n, D. Muddiman n

UN Sustainable Development Goal Categories
2. Zero Hunger (OpenAlex)
Sources: Web Of Science, ORCID, NC State University Libraries
Added: August 6, 2018

2010 journal article

The impact of scheduled cage cleaning on older hens (Gallus gallus)

LAB ANIMAL, 39(7), 210–215.

By: K. Anderson n, P. Mozdziak n & J. Petitte n

Contributors: K. Anderson n, P. Mozdziak n & J. Petitte n

MeSH headings : Animal Husbandry / methods; Animals; Chickens / physiology; Female; Housing, Animal; Longevity / physiology; Ovulation / physiology; Time Factors
TL;DR: It is suggested that regularly cleaning the cages of older hens may not promote better welfare or improve flock mortality, and it may be necessary to remove hens for cage changing once every 4 weeks. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (Web of Science; OpenAlex)
Sources: Web Of Science, ORCID, NC State University Libraries
Added: August 6, 2018

2010 patent

Transgenic snakes and methods of making

By: P. Mozdziak & J. Petitte

Source: NC State University Libraries
Added: August 6, 2018

2009 journal article

Apoptosis and macrophage infiltration occur simultaneously and present a potential sign of muscle injury in skeletal muscle of nutritionally compromised, early post-hatch turkeys

COMPARATIVE BIOCHEMISTRY AND PHYSIOLOGY B-BIOCHEMISTRY & MOLECULAR BIOLOGY, 153(1), 61–65.

By: L. Nierobisz n, J. Felts n & P. Mozdziak n

Contributors: L. Nierobisz n, J. Felts n & P. Mozdziak n

author keywords: Amino acids; Apoptosis; Feed deprivation; Macrophages; Muscle; Satellite cells; Turkey
MeSH headings : Analysis of Variance; Animal Nutritional Physiological Phenomena / physiology; Animals; Apoptosis / physiology; Macrophages / metabolism; Muscle, Skeletal / metabolism; Muscle, Skeletal / physiopathology; Poultry Diseases / diagnosis; Poultry Diseases / metabolism; Poultry Diseases / physiopathology; Turkeys
TL;DR: To histochemically determine the association of apoptosis and/or macrophage infiltration with changes in muscle satellite cell mitotic activity in pectoralis thoracicus muscle of early post-hatch turkey toms, three different levels of crude protein and amino acids were used. (via Semantic Scholar)
UN Sustainable Development Goal Categories
2. Zero Hunger (OpenAlex)
Sources: Web Of Science, ORCID, NC State University Libraries
Added: August 6, 2018

2009 journal article

IDENTIFICATION OF POULTRY MEAT FROM PORK AND BEEF ON THE BASIS OF THE TITIN PEVK REGION USING PCR

JOURNAL OF MUSCLE FOODS, 20(3), 341–351.

By: A. Spychaj*, P. Mozdziak n & E. Pospiech*

Contributors: A. Spychaj*, P. Mozdziak n & E. Pospiech*

TL;DR: The data presented in this study suggest that it is possible to detect chicken meat, pork and beef in meat mixtures on the basis of PEVK region by using PCR. (via Semantic Scholar)
Sources: Web Of Science, ORCID, NC State University Libraries
Added: August 6, 2018

2009 journal article

PCR methods in meat species identification as a tool for the verification of regional and traditional meat products,Metody PCR w identyfikacji gatunkowej żywności jako narze{ogonek}dzie do weryfikacji żywno̧sci regionalnej i tradycyjnej

Acta Scientiarum Polonorum, Technologia Alimentaria, 8(2), 5–20. http://www.scopus.com/inward/record.url?eid=2-s2.0-70349779654&partnerID=MN8TOARS

By: A. Spychaj, P. Mozdziak & E. Pospiech

Contributors: A. Spychaj, P. Mozdziak & E. Pospiech

Source: ORCID
Added: January 2, 2020

2008 journal article

Avian somitic cell chimeras using surrogate eggshell technology

Asian-Australasian Journal of Animal Sciences, 21(6), 801–806.

By: P. Mozdziak*, D. Hodgson & J. Petitte

Contributors: P. Mozdziak*, D. Hodgson & J. Petitte

author keywords: embryo; chick; transgenic; eGFP
TL;DR: Using a surrogate eggshell system in conjunction with transgenic chick:chick somitic cell cross-transplantation to generate viable chimeric embryos and offspring to remove any possibility of interspecies graft rejection. (via Semantic Scholar)
Source: ORCID
Added: January 2, 2020

2008 journal article

Broiler embryo bone development is influenced by incubator temperature, oxygen concentration and eggshell conductance at the plateau stage in oxygen consumption

BRITISH POULTRY SCIENCE, 49(6), 666–676.

By: E. Oviedo-Rondon n, J. Small n, M. Wineland n, V. Christensen n, P. Mozdziak n, M. Koci n, S. Funderburk n, D. Ort n, K. Mann n

Contributors: E. Oviedo-Rondón n, J. Small n, M. Wineland n, V. Christensen n, P. Mozdziak n, M. Koci n, S. Funderburk n, D. Ort n, K. Mann n

MeSH headings : Animals; Body Weight; Bone Development / drug effects; Chick Embryo; Chickens / anatomy & histology; Chickens / growth & development; Chickens / metabolism; Egg Shell / physiology; Embryonic Development / drug effects; Femur / anatomy & histology; Incubators; Oxygen / metabolism; Oxygen / pharmacology; Temperature; Tibia / anatomy & histology
TL;DR: The results indicated that elevated TEM during incubation increased RA between the two legs, mainly in the Low G strain, and suggest that late incubation conditions affect long bone development in broilers. (via Semantic Scholar)
Sources: ORCID, Web Of Science, NC State University Libraries
Added: August 6, 2018

2008 review

Factors influencing satellite cell activity during skeletal muscle development in avian and mammalian species

[Review of ]. ASIAN-AUSTRALASIAN JOURNAL OF ANIMAL SCIENCES, 21(3), 456–464.

By: L. Nierobisz n & P. Mozdziak n

Contributors: L. Nierobisz n & P. Mozdziak n

author keywords: muscle regeneration; muscle development; mitogenic factors; meat production; poultry; mammals
TL;DR: The regenerative properties ofatellite cells, the processes of satellite cell activation and the potential role of satellite cells in skeletal muscle growth, tissue engineering and meat production are highlighted. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Sources: Web Of Science, ORCID, NC State University Libraries
Added: August 6, 2018

2007 journal article

CA125 expression in spontaneous ovarian adenocarcinomas from laying hens

Gynecologic Oncology, 104(1), 192–198.

By: E. Jackson, K. Anderson*, C. Ashwell*, J. Petitte* & P. Mozdziak*

Contributors: E. Jackson, K. Anderson*, C. Ashwell*, J. Petitte* & P. Mozdziak*

author keywords: ovarian cancer; chicken; avian; cancer markers; in vitro; Western blotting
MeSH headings : Adenocarcinoma / pathology; Animals; Blotting, Western; CA-125 Antigen / biosynthesis; Cell Growth Processes / physiology; Chickens; Disease Models, Animal; Female; Immunohistochemistry; Ovarian Neoplasms / immunology; Ovarian Neoplasms / pathology
TL;DR: The growth of avian tumors in culture fits a sigmoidal curve for cell growth and suggests a cell cycle time of 28 h, and CA125 expression does not appear to change with time in culture. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (OpenAlex)
Sources: ORCID, Crossref, NC State University Libraries
Added: January 2, 2020

2007 journal article

Effect of Incubator Temperature and Oxygen Concentration at the Plateau Stage in Oxygen Consumption on Turkey Embryo Muscle Growth and Development

International Journal of Poultry Science, 6(6), 406–412.

By: V. Christensen, M. J. Wineland, J. L. Grimes, E. O. Oviedo, P. . Mozdziak, D. T. Ort, K. M. Mann

Contributors: V. Christensen, M. Wineland, J. Grimes, E. Oviedo, P. Mozdziak*, D. Ort, K. Mann

TL;DR: Muscle function was affected differently when embryos were exposed to TEM and O and incubator conditions may affect muscle development and function in poult embryos. (via Semantic Scholar)
UN Sustainable Development Goal Categories
2. Zero Hunger (OpenAlex)
Sources: ORCID, Crossref, NC State University Libraries
Added: March 18, 2019

2007 journal article

The effect of early dietary amino acid levels on muscle satellite cell dynamics in turkeys

COMPARATIVE BIOCHEMISTRY AND PHYSIOLOGY B-BIOCHEMISTRY & MOLECULAR BIOLOGY, 148(3), 286–294.

By: L. Nierobisz n, V. Felts n & P. Mozdziak n

Contributors: L. Nierobisz n, V. Felts n & P. Mozdziak n

author keywords: amino acids; feed deprivation; muscle; satellite cells; turkey
MeSH headings : Amino Acids / administration & dosage; Amino Acids / metabolism; Animals; Diet; Immunohistochemistry; Male; Muscles / cytology; Muscles / metabolism; Turkeys
TL;DR: Research evaluating species-related differences in apoptotic events and in genes regulating cell proliferation may be necessary to devise feeding strategies aimed at obtaining optimal pectoralis thoracicus muscle yield at market age. (via Semantic Scholar)
UN Sustainable Development Goal Categories
2. Zero Hunger (OpenAlex)
Sources: Web Of Science, ORCID, NC State University Libraries
Added: August 6, 2018

2007 article

The incredible, edible, and therapeutic egg

Petitte, J. N., & Mozdziak, P. E. (2007, February 6). PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, Vol. 104, pp. 1739–1740.

By: J. Petitte n & P. Mozdziak n

Contributors: J. Petitte n & P. Mozdziak n

MeSH headings : Animals; Animals, Genetically Modified; Chickens / genetics; Egg Proteins / biosynthesis; Egg Proteins / genetics; Egg Proteins / therapeutic use; Eggs; Gene Transfer Techniques; Humans; Lentivirus / genetics; Ovum
TL;DR: The chicken model provided the foundation for understanding the chemical processes for vision, insights into animal behavior, and the first introduction to tumor viruses and the cellular origin of retroviral oncogenes, as well as providing valuable models for human disease. (via Semantic Scholar)
Sources: Web Of Science, ORCID, NC State University Libraries
Added: August 6, 2018

2006 journal article

Blood-borne stem cells differentiate into vascular and cardiac lineages during normal development

Stem Cells and Development, 15(1), 17–28.

By: N. Zhang*, D. Mustin*, W. Reardon*, A. DeAlmeida*, P. Mozdziak n, M. Mrug*, L. Eisenberg*, D. Sedmera*

Contributors: N. Zhang*, D. Mustin*, W. Reardon*, A. DeAlmeida*, P. Mozdziak n, M. Mrug*, L. Eisenberg*, D. Sedmera*

MeSH headings : Animals; Cell Differentiation; Cells, Cultured; Central Nervous System / cytology; Chick Embryo; Chickens; Endothelium, Vascular / cytology; Endothelium, Vascular / embryology; Endothelium, Vascular / ultrastructure; Heart / embryology; Hematopoietic Stem Cell Transplantation; Hematopoietic Stem Cells / physiology; Kidney / cytology; Kidney / ultrastructure; Liver / cytology; Lung / cytology; Myocardium / cytology; Parabiosis; Quail
TL;DR: The demonstration that blood-borne cells contribute to the development of various organs of the developing embryo using a quail-chick parabiosis model lends credence to claims that hematopoietic stem cells have utility for treating diseased or damaged tissues in the adult. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (Web of Science; OpenAlex)
Source: ORCID
Added: January 2, 2020

2006 journal article

Identification of the lacZ insertion site and beta-galactosidase expression in transgenic chickens

CELL AND TISSUE RESEARCH, 324(1), 41–53.

By: P. Mozdziak n, Q. Wu n, J. Bradford n, S. Pardue n, S. Borwornpinyo n, C. Giamario n, J. Petitte n

Contributors: P. Mozdziak n, Q. Wu n, J. Bradford n, S. Pardue n, S. Borwornpinyo n, C. Giamario n, J. Petitte n

author keywords: beta-galactosidase; neurotactin; inverse polymerase chain reaction; genotyping; lacZ; NCSU-Blue1; chicken
MeSH headings : Animals; Animals, Genetically Modified; Base Sequence; Blotting, Southern; Chemokine CX3CL1; Chemokines, CX3C / metabolism; Chick Embryo; Chickens; Female; Genotype; Lac Operon; Male; Membrane Proteins / metabolism; Molecular Sequence Data; Mutagenesis, Insertional; Sequence Homology, Nucleic Acid; beta-Galactosidase / metabolism
TL;DR: With the identification of homozygous birds, the line of chickens is now designated NCSU-Blue1 and the viral insertion carrying the lacZ gene has been located on chromosome 11 within the predicted gene for neurotactin/fractalkine (CX3CL1). (via Semantic Scholar)
UN Sustainable Development Goal Categories
2. Zero Hunger (OpenAlex)
Sources: Web Of Science, ORCID, NC State University Libraries
Added: August 6, 2018

2006 journal article

Production of chick germline chimeras from fluorescence-activated cell-sorted gonocytes

POULTRY SCIENCE, 85(10), 1764–1768.

By: P. Mozdziak n, R. Wysocki n, J. Angerman-Stewart n, S. Pardue n & J. Petitte n

Contributors: P. Mozdziak n, R. Wysocki n, J. Angerman-Stewart n, S. Pardue n & J. Petitte n

author keywords: gonad; stage-specific embryonic antigen-1; testes; fluorescence-activated cell sorting; primordial germ cell
MeSH headings : Animals; Cell Separation / methods; Cell Separation / veterinary; Chick Embryo / cytology; Chick Embryo / embryology; Chick Embryo / metabolism; Chimera / embryology; Embryo Culture Techniques / veterinary; Female; Flow Cytometry; Germ Cells / cytology; Germ Cells / transplantation; Male; Testis / cytology; Testis / embryology
TL;DR: It was demonstrated that gonocytes isolated from stage 27 embryonic gonads can be introduced into embryos at an earlier stage of development, and the introduced gonocytes can fully participate in germline development. (via Semantic Scholar)
Sources: Web Of Science, ORCID, NC State University Libraries
Added: August 6, 2018

2006 journal article

Satellite cells express distinct patterns of myogenic proteins in immature skeletal muscle

DEVELOPMENTAL DYNAMICS, 235(12), 3230–3239.

By: E. Schultz*, C. Chamberlain*, K. McCormick* & P. Mozdziak n

Contributors: E. Schultz*, C. Chamberlain*, K. McCormick* & P. Mozdziak n

author keywords: muscle; myonuclei; interstitial cells; fibroblasts; stem cells
MeSH headings : Animals; Cell Nucleus / metabolism; Immunohistochemistry; Male; Muscle Proteins / metabolism; Muscle, Skeletal / cytology; Muscle, Skeletal / growth & development; Muscle, Skeletal / metabolism; MyoD Protein / metabolism; Myogenin / metabolism; PAX7 Transcription Factor / metabolism; Rats; Rats, Sprague-Dawley; Satellite Cells, Skeletal Muscle / metabolism
TL;DR: Results from this study suggest that expression patterns of MyoD, myogenin, and Pax7 vary predictably among muscles with different growth dynamics and phenotypic characteristics. (via Semantic Scholar)
Sources: Web Of Science, ORCID, NC State University Libraries
Added: August 6, 2018

2005 journal article

Culture of chicken embryos in surrogate eggshells

POULTRY SCIENCE, 84(9), 1477–1482.

By: S. Borwornpinyo, J. Brake n, P. Mozdziak n & J. Petitte n

Contributors: S. Borwornpinyo, J. Brake n, P. Mozdziak n & J. Petitte n

author keywords: surrogate eggshell; avian embryo culture; transgenic bird; hatchability
MeSH headings : Animals; Chick Embryo / growth & development; Egg Shell; Time Factors; Tissue Culture Techniques / methods; Tissue Culture Techniques / veterinary; Turkeys
TL;DR: Hatchability of cultured embryos cultured in turkey eggshells and sealed with Handi Wrap exhibited higher hatchability than cultures sealed with Saran Wrap, which suggested that Handi wrap was an excellent sealant for chick embryos cultured after 3 d of incubation. (via Semantic Scholar)
UN Sustainable Development Goal Categories
6. Clean Water and Sanitation (OpenAlex)
Sources: Web Of Science, ORCID, NC State University Libraries
Added: August 6, 2018

2005 journal article

Early post-hatch fasting induces satellite cell self-renewal

COMPARATIVE BIOCHEMISTRY AND PHYSIOLOGY A-MOLECULAR & INTEGRATIVE PHYSIOLOGY, 142(3), 331–339.

By: D. Moore n, P. Ferket n & P. Mozdziak n

Contributors: D. Moore n, P. Ferket n & P. Mozdziak n

author keywords: fasting; feed deprivation; Pax7; BrdU; Bcl-2; turkey; avian; muscle
MeSH headings : Animal Nutritional Physiological Phenomena; Animals; Body Weight; Bromodeoxyuridine; Food Deprivation / physiology; Male; Mitosis / physiology; Muscle Development / physiology; Pectoralis Muscles / cytology; Pectoralis Muscles / growth & development; Satellite Cells, Skeletal Muscle / physiology; Turkeys / growth & development
TL;DR: Early post-hatch satellite cell kinetics are an important aspect of muscle development, and understanding the interplay between fasting and muscle development will lead to improvements in muscle mass following an illness, and optimal meat production. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Sources: Web Of Science, ORCID, NC State University Libraries
Added: August 6, 2018

2005 journal article