Paul Gallins
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Works (14)
Updated: July 9th, 2023 15:10
2023 journal article
Genetic Modifiers of Cystic Fibrosis Lung Disease Severity
AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE, 207(10), 1324–1333.
author keywords: cystic fibrosis; whole-genome sequencing; lung disease severity; GWAS/TWAS; pathway analyses
MeSH headings : Humans; Cystic Fibrosis / genetics; Genome-Wide Association Study / methods; Cystic Fibrosis Transmembrane Conductance Regulator / genetics; Patient Acuity; Lung; Microtubule-Associated Proteins / genetics
Sources: Web Of Science, ORCID
Added: May 16, 2023
2022 journal article
A Population-Based Human In Vitro Approach to Quantify Inter-Individual Variability in Responses to Chemical Mixtures
TOXICS, 10(8).
author keywords: population-wide; inter-individual variability; toxicodynamics; chemical mixtures; defined mixtures; human health risk assessment; uncertainty factors; genome-wide association study
www.mdpi.com (publisher PDF)
Sources: Web Of Science, ORCID
Added: August 2, 2022
2022 journal article
A resource for integrated genomic analysis of the human liver
SCIENTIFIC REPORTS, 12(1).
MeSH headings : Bayes Theorem; Genome-Wide Association Study / methods; Genomics; Humans; Liver; Polymorphism, Single Nucleotide; Quantitative Trait Loci
Sources: Web Of Science, ORCID
Added: September 8, 2022
2022 journal article
Identification and single-base gene-editing functional validation of a cis-EPO variant as a genetic predictor for EPO-increasing therapies
AMERICAN JOURNAL OF HUMAN GENETICS, 109(9), 1638–1652.
MeSH headings : Anemia / drug therapy; Anemia / genetics; Coronary Artery Disease / genetics; Genome-Wide Association Study; Humans; Mendelian Randomization Analysis; Myocardial Infarction / genetics; Renal Insufficiency, Chronic / genetics
Source: Web Of Science
Added: November 21, 2022
2022 journal article
Leveraging TOPMed imputation server and constructing a cohort-specific imputation reference panel to enhance genotype imputation among cystic fibrosis patients
HUMAN GENETICS AND GENOMICS ADVANCES, 3(2).
Sources: Web Of Science, ORCID
Added: May 10, 2022
2020 journal article
A New Liver Expression Quantitative Trait Locus Map From 1,183 Individuals Provides Evidence for Novel Expression Quantitative Trait Loci of Drug Response, Metabolic, and Sex-Biased Phenotypes
CLINICAL PHARMACOLOGY & THERAPEUTICS, 107(6), 1383–1393.
MeSH headings : Adolescent; Adult; Aged; Aged, 80 and over; Antineoplastic Agents / adverse effects; Antineoplastic Agents / pharmacology; Child; Child, Preschool; Female; Gene Expression Regulation / genetics; Genetic Variation; Genome-Wide Association Study; Genotype; Humans; Hypolipidemic Agents / pharmacology; Infant; Liver / metabolism; Male; Middle Aged; Phenotype; Proprotein Convertase 9 / genetics; Quantitative Trait Loci / genetics; Receptors, G-Protein-Coupled / genetics; Sex Factors; Young Adult
Sources: Web Of Science, ORCID
Added: February 10, 2020
2020 journal article
Exploring the Limits of Combined Image/'omics Analysis for Non-cancer Histological Phenotypes
FRONTIERS IN GENETICS, 11.
author keywords: imaging; genomics; pathology; prediction; integration; histology; machine learning; embedding
Sources: Web Of Science, ORCID
Added: November 24, 2020
2019 review
A Review and Tutorial of Machine Learning Methods for Microbiome Host Trait Prediction
[Review of ]. FRONTIERS IN GENETICS, 10.
author keywords: disease; phenotype; modeling; machine learning; prediction
Sources: Web Of Science, ORCID
Added: July 15, 2019
2018 journal article
A common allele in FGF21 associated with sugar intake is associated with body shape, lower total body-fat percentage, and higher blood pressure
Cell Reports, 23(2), 327–336.
Source: NC State University Libraries
Added: August 6, 2018
2018 journal article
A zero-inflated beta-binomial model for microbiome data analysis
STAT, 7(1).
author keywords: count data; penalized generalized linear model; zero-inflated beta-binomial modelling
Sources: Web Of Science, ORCID, NC State University Libraries
Added: August 6, 2018
2018 journal article
Airway mucosal host defense is key to genomic regulation of cystic fibrosis lung disease severity
American Journal of Respiratory and Critical Care Medicine, 197(1), 79–93.
Source: NC State University Libraries
Added: August 6, 2018
2016 journal article
Genomic Characterization of Metformin Hepatic Response
PLOS GENETICS, 12(11).
MeSH headings : AMP-Activated Protein Kinases / biosynthesis; AMP-Activated Protein Kinases / genetics; Activating Transcription Factor 3 / genetics; Adaptor Proteins, Signal Transducing / genetics; Ataxia Telangiectasia Mutated Proteins / biosynthesis; Ataxia Telangiectasia Mutated Proteins / genetics; DEAD-box RNA Helicases / genetics; Diabetes Mellitus, Type 2 / drug therapy; Diabetes Mellitus, Type 2 / genetics; Diabetes Mellitus, Type 2 / pathology; Enhancer Elements, Genetic; Gene Knockdown Techniques; Gluconeogenesis / genetics; Haplotypes; Hepatocytes / drug effects; Hepatocytes / metabolism; Humans; Linkage Disequilibrium; Liver / drug effects; Liver / metabolism; Metformin / adverse effects; Metformin / therapeutic use; Polymorphism, Single Nucleotide
Source: Web Of Science
Added: August 6, 2018
2016 conference paper
Poster: risk-based attack surface approximation
Symposium and Bootcamp on the Science of Security, 121–123.
Source: NC State University Libraries
Added: August 6, 2018
2015 journal article
Population-Based in Vitro Hazard and Concentration-Response Assessment of Chemicals: The 1000 Genomes High-Throughput Screening Study
ENVIRONMENTAL HEALTH PERSPECTIVES, 123(5), 458–466.
MeSH headings : Cell Line, Tumor; Genome-Wide Association Study / methods; Genotype; Humans; Risk Assessment; Toxicity Tests / methods
Source: Web Of Science
Added: August 6, 2018
