Works (38)

Updated: August 31st, 2023 05:01

2023 journal article

Assembly path dependence of telomeric DNA compaction by TRF1, TIN2, and SA1

BIOPHYSICAL JOURNAL, 122(10), 1822–1832.

By: M. Liu n, H. Pan n, P. Kaur n, L. Wang n, M. Jin*, A. Detwiler*, P. Opresko*, Y. Tao*, H. Wang n, R. Riehn n

Sources: Web Of Science, ORCID
Added: April 21, 2023

2023 article

PARP1 associates with R-loops to promote their resolution and genome stability

Laspata, N., Kaur, P., Mersaoui, S. Y., Muoio, D., Liu, Z. S., Bannister, M. H., … Fouquerel, E. (2023, February 16). NUCLEIC ACIDS RESEARCH, Vol. 2.

By: N. Laspata*, P. Kaur*, S. Mersaoui*, D. Muoio*, Z. Liu*, M. Bannister*, H. Nguyen*, C. Curry* ...

MeSH headings : Humans; DNA / chemistry; DNA Repair; Genomic Instability; Poly (ADP-Ribose) Polymerase-1 / genetics; Poly (ADP-Ribose) Polymerase-1 / metabolism; R-Loop Structures; RNA / chemistry
Sources: Web Of Science, ORCID
Added: March 20, 2023

2023 article

Structure-specific roles for PolG2-DNA complexes in maintenance and replication of mitochondrial DNA

Wojtaszek, J. L., Hoff, K. E., Longley, M. J., Kaur, P., Andres, S. N., Wang, H., … Copeland, W. C. (2023, August 18). NUCLEIC ACIDS RESEARCH, Vol. 8.

Sources: Web Of Science, ORCID
Added: August 28, 2023

2022 journal article

Densely methylated DNA traps Methyl-CpG-binding domain protein 2 but permits free diffusion by Methyl-CpG-binding domain protein 3

JOURNAL OF BIOLOGICAL CHEMISTRY, 298(10).

By: G. Leighton, E. Irvin*, P. Kaur*, M. Liu*, C. You, D. Bhattaram, J. Piehler, R. Riehn* ...

MeSH headings : CpG Islands; DNA Methylation; DNA-Binding Proteins / metabolism; Mi-2 Nucleosome Remodeling and Deacetylase Complex / genetics; Mi-2 Nucleosome Remodeling and Deacetylase Complex / metabolism; Nucleosomes; Protein Binding; Transcription Factors / metabolism; Humans; Single Molecule Imaging
Sources: Web Of Science, ORCID
Added: August 29, 2022

2022 article

Structural and dynamic basis of DNA capture and translocation by mitochondrial Twinkle helicase

Li, Z., Kaur, P., Lo, C.-Y., Chopra, N., Smith, J., Wang, H., & Gao, Y. (2022, November 18). NUCLEIC ACIDS RESEARCH, Vol. 11.

By: Z. Li*, P. Kaur n, C. Lo*, N. Chopra*, J. Smith*, H. Wang n, Y. Gao*

MeSH headings : Humans; Mitochondrial Proteins / metabolism; Cryoelectron Microscopy; DNA Helicases / metabolism; Mitochondria / genetics; Mitochondria / metabolism; DNA Replication; DNA, Mitochondrial / genetics
Sources: Web Of Science, ORCID
Added: December 5, 2022

2021 journal article

Structure, dynamics, and regulation of TRF1-TIN2-mediated trans- and cis-interactions on telomeric DNA

JOURNAL OF BIOLOGICAL CHEMISTRY, 297(3).

By: H. Pan n, P. Kaur n, R. Barnes*, A. Detwiler*, S. Sanford*, M. Liu n, P. Xu n, C. Mahn n ...

MeSH headings : Cell Adhesion Molecules / metabolism; Cell Adhesion Molecules / physiology; DNA / metabolism; DNA-Binding Proteins / metabolism; Humans; Microscopy, Atomic Force / methods; Models, Molecular; Multiprotein Complexes / metabolism; Protein Binding; Protein Isoforms / metabolism; Shelterin Complex / metabolism; Shelterin Complex / physiology; Telomere / metabolism; Telomere-Binding Proteins / metabolism; Telomere-Binding Proteins / physiology; Telomeric Repeat Binding Protein 1 / metabolism; Telomeric Repeat Binding Protein 1 / physiology; Telomeric Repeat Binding Protein 2 / metabolism; Telomeric Repeat Binding Protein 2 / physiology
Sources: Web Of Science, ORCID
Added: October 26, 2021

2021 journal article

TIN2 is an architectural protein that facilitates TRF2-mediated trans- and cis-interactions on telomeric DNA

NUCLEIC ACIDS RESEARCH, 49(22), 13000–13018.

By: P. Kaur n, R. Barnes*, H. Pan n, A. Detwiler*, M. Liu n, C. Mahn n, J. Hall n, Z. Messenger n ...

MeSH headings : Animals; DNA / chemistry; DNA / genetics; DNA / metabolism; HeLa Cells; Humans; Mice, Inbred C57BL; Microscopy, Atomic Force; Nucleic Acid Conformation; Protein Binding; Shelterin Complex / genetics; Shelterin Complex / metabolism; Telomere / genetics; Telomere / metabolism; Telomere-Binding Proteins / genetics; Telomere-Binding Proteins / metabolism; Telomeric Repeat Binding Protein 2 / genetics; Telomeric Repeat Binding Protein 2 / metabolism
Sources: Web Of Science, ORCID
Added: January 18, 2022

2021 journal article

Using Atomic Force Microscopy to Study the Real Time Dynamics of DNA Unwinding by Mitochondrial Twinkle Helicase

BIO-PROTOCOL, 11(17).

By: P. Kaur*, H. Pan*, M. Longley, W. Copeland & H. Wang*

author keywords: Atomic Force Microscope; Twinkle helicase; Mitochondria; Liquid AFM imaging; Mitochondrial replication; Single molecule imaging
Source: Web Of Science
Added: September 20, 2021

2020 journal article

Cohesin SA1 and SA2 are RNA binding proteins that localize to RNA containing regions on DNA

NUCLEIC ACIDS RESEARCH, 48(10), 5639–5655.

By: H. Pan n, M. Jin*, A. Ghadiyaram n, P. Kaur n, H. Miller*, H. Ta*, M. Liu n, Y. Fan* ...

MeSH headings : Binding Sites; Cell Cycle Proteins / metabolism; Chromosomal Proteins, Non-Histone / metabolism; DNA / metabolism; R-Loop Structures; RNA / metabolism; RNA-Binding Proteins / metabolism
Sources: Web Of Science, ORCID
Added: October 5, 2020

2020 journal article

DNA looping by two 5-methylcytosine-binding proteins quantified using nanofluidic devices

EPIGENETICS & CHROMATIN, 13(1).

By: M. Liu n, S. Movahed n, S. Dangi n, H. Pan n, P. Kaur n, S. Bilinovich*, E. Faison*, G. Leighton* ...

author keywords: DNA methylation; MeCP2; MBD2; DNA compaction
MeSH headings : 5-Methylcytosine / chemistry; 5-Methylcytosine / metabolism; Binding Sites; DNA / chemistry; DNA / metabolism; DNA Methylation; DNA-Binding Proteins / chemistry; DNA-Binding Proteins / metabolism; Epigenomics / methods; Humans; Methyl-CpG-Binding Protein 2 / chemistry; Methyl-CpG-Binding Protein 2 / metabolism; Microfluidics / instrumentation; Microfluidics / methods; Microscopy, Atomic Force / methods; Protein Binding
Sources: Web Of Science, ORCID
Added: April 20, 2020

2020 journal article

Single-molecule level structural dynamics of DNA unwinding by human mitochondrial Twinkle helicase

JOURNAL OF BIOLOGICAL CHEMISTRY, 295(17), 5564–5576.

author keywords: atomic force microscopy (AFM); DNA binding protein; DNA helicase; DNA replication; mitochondrial disease; mitochondrial DNA (mtDNA); single-molecule biophysics; ssDNA-binding protein (SSB); structural dynamics; Twinkle helicase
MeSH headings : DNA / analysis; DNA / metabolism; DNA Helicases / analysis; DNA Helicases / metabolism; Humans; Microscopy, Atomic Force; Mitochondria / metabolism; Mitochondrial Proteins / analysis; Mitochondrial Proteins / metabolism; Nucleic Acid Conformation; Protein Binding; Protein Multimerization; Recombinant Proteins / analysis; Recombinant Proteins / metabolism
Source: Web Of Science
Added: May 18, 2020

2019 journal article

Cohesin SA2 and EWSR1 in R-Loop Regulation

Biophysical Journal, 116(3), 505a.

By: H. Wang n, A. Ghadiyaram n, H. Pan n, Y. Fan*, P. Kaur n, A. Gorthi*, R. Riehn n, A. Bishop*, Y. Jane Tao*

Sources: Crossref, ORCID
Added: January 25, 2020

2019 journal article

Single-Molecule Study of TRF2 Mediated DNA Compaction using Physiologically Relevant Long Telomeric DNA

Biophysical Journal, 116(3), 505a.

By: P. Kaur n, R. Barnes*, H. Pan n, P. Opresko*, R. Riehn n & H. Wang n

Sources: Crossref, ORCID
Added: January 25, 2020

2019 journal article

TIN2 is an Architectural Protein Stabilizing TRF1 at Telomere

Biophysical Journal, 116(3), 211a–212a.

By: H. Pan n, S. Dangi n, P. Kaur n, P. Hao n, K. Weninger n, R. Riehn n, P. Opresko*, H. Wang n

Sources: Crossref, ORCID
Added: January 25, 2020

2018 journal article

Cohesin SA2 is a sequence-independent DNA-binding protein that recognizes DNA replication and repair intermediates

JOURNAL OF BIOLOGICAL CHEMISTRY, 293(3), 1054–1069.

By: P. Countryman n, Y. Fan*, A. Gorthi*, H. Pan n, J. Strickland n, P. Kaur n, X. Wang n, J. Lin n ...

MeSH headings : Cell Cycle Proteins / chemistry; Cell Cycle Proteins / metabolism; Chromosomal Proteins, Non-Histone / chemistry; Chromosomal Proteins, Non-Histone / metabolism; DNA Repair / genetics; DNA Repair / physiology; DNA Replication / physiology; DNA-Binding Proteins / chemistry; DNA-Binding Proteins / metabolism; Fluorescence Polarization; Genomic Instability / genetics; Genomic Instability / physiology; Microscopy, Atomic Force; Microscopy, Fluorescence; Protein Binding / genetics; Protein Binding / physiology
Sources: Web Of Science, ORCID
Added: August 6, 2018

2018 journal article

Single-molecule DREEM imaging reveals DNA wrapping around human mitochondrial single-stranded DNA binding protein

NUCLEIC ACIDS RESEARCH, 46(21), 11287–11302.

By: P. Kaur n, M. Longley*, H. Pan n, H. Wang n & W. Copeland*

MeSH headings : DNA, Mitochondrial / chemistry; DNA, Mitochondrial / metabolism; DNA, Single-Stranded / chemistry; DNA, Single-Stranded / metabolism; DNA-Binding Proteins / analysis; DNA-Binding Proteins / chemistry; DNA-Binding Proteins / metabolism; Fluorescence Polarization; Humans; Microscopy, Atomic Force / methods; Mitochondrial Proteins / analysis; Mitochondrial Proteins / chemistry; Mitochondrial Proteins / metabolism; Protein Conformation; Protein Stability; Recombinant Proteins / genetics; Single Molecule Imaging / methods; Static Electricity
Sources: Web Of Science, ORCID
Added: February 11, 2019

2017 journal article

CpG and methylation-dependent DNA binding and dynamics of the methylcytosine binding domain 2 protein at the single-molecule level

NUCLEIC ACIDS RESEARCH, 45(15), 9164–9177.

By: H. Pan n, S. Bilinovich*, P. Kaur n, R. Riehn n, H. Wang n & D. Williams*

MeSH headings : 5-Methylcytosine / chemistry; 5-Methylcytosine / metabolism; Animals; Binding Sites; Chickens; Cloning, Molecular; CpG Islands; DNA / chemistry; DNA / metabolism; DNA Methylation; DNA-Binding Proteins / chemistry; DNA-Binding Proteins / genetics; DNA-Binding Proteins / metabolism; Escherichia coli / genetics; Escherichia coli / metabolism; Fluorescence Polarization; Gene Expression; Humans; Magnetic Resonance Spectroscopy; Mi-2 Nucleosome Remodeling and Deacetylase Complex / metabolism; Mi-2 Nucleosome Remodeling and Deacetylase Complex / ultrastructure; Nucleic Acid Conformation; Nucleosomes / metabolism; Nucleosomes / ultrastructure; Protein Binding; Protein Isoforms / chemistry; Protein Isoforms / genetics; Protein Isoforms / metabolism; Recombinant Proteins / chemistry; Recombinant Proteins / genetics; Recombinant Proteins / metabolism; Single Molecule Imaging
Sources: Web Of Science, ORCID
Added: August 6, 2018

2017 journal article

Nucleosome-like, Single-stranded DNA (ssDNA)-Histone Octamer Complexes and the Implication for DNA Double Strand Break Repair

JOURNAL OF BIOLOGICAL CHEMISTRY, 292(13), 5271–5281.

MeSH headings : Chromatin Assembly and Disassembly / genetics; DNA Breaks, Double-Stranded; DNA Repair / genetics; DNA, Single-Stranded / metabolism; Genomic Instability; Histones / metabolism; Nucleosomes / metabolism; Protein Processing, Post-Translational; Saccharomyces cerevisiae / genetics; Saccharomyces cerevisiae Proteins / metabolism; Transcription Factors / metabolism
Source: Web Of Science
Added: August 6, 2018

2017 journal article

Single Molecule Fluorescence and Atomic Force Microscopy Studies of DNA Repair

Biophysical Journal, 112(3), 7a.

By: D. Erie*, K. Bradford*, H. Wilkins*, J. Bower*, Z. Wang*, J. Gauer*, M. Satusky*, R. Qiu n ...

Sources: Crossref, ORCID
Added: February 5, 2020

2017 journal article

Using atomic force microscopy to characterize the conformational properties of proteins and protein-DNA complexes that carry out DNA repair

DNA Repair Enzymes: Structure, Biophysics, and Mechanism, 592, 187–212.

By: S. LeBlanc, H. Wilkins, Z. Li, P. Kaur, H. Wang & D. Erie

Source: NC State University Libraries
Added: August 6, 2018

2017 journal article

Walking the DNA Methylation Tightrope: The Involvement of Intrinsically Disordered Regions of Transcription Factors

Biophysical Journal, 112(3), 207a.

By: S. Bilinovich*, H. Pan n, P. Kaur n, H. Wang n & D. Williams*

Sources: Crossref, ORCID
Added: February 24, 2020

2016 journal article

Enhanced electrostatic force microscopy reveals higher-order DNA looping mediated by the telomeric protein TRF2

Scientific Reports, 6(1).

MeSH headings : DNA / chemistry; DNA / metabolism; HeLa Cells; Humans; Microscopy; Multiprotein Complexes / chemistry; Multiprotein Complexes / metabolism; Nucleic Acid Conformation; Static Electricity; Telomeric Repeat Binding Protein 2 / chemistry; Telomeric Repeat Binding Protein 2 / metabolism
Sources: Crossref, ORCID, NC State University Libraries
Added: August 6, 2018

2016 journal article

Functional interplay between SA1 and TRF1 in telomeric DNA binding and DNA-DNA pairing

NUCLEIC ACIDS RESEARCH, 44(13), 6363–6376.

By: J. Lin n, P. Countryman n, H. Chen*, H. Pan n, Y. Fan*, Y. Jiang*, P. Kaur n, W. Miao* ...

MeSH headings : AT-Hook Motifs / genetics; Chromatids / genetics; Chromatids / ultrastructure; Chromosome Segregation / genetics; DNA-Binding Proteins / genetics; Humans; Microscopy, Atomic Force; Mitosis / genetics; Nuclear Proteins / genetics; Nuclear Proteins / metabolism; Telomere / genetics; Telomere / ultrastructure; Telomere-Binding Proteins / genetics; Telomere-Binding Proteins / metabolism; Telomeric Repeat Binding Protein 1 / genetics; Telomeric Repeat Binding Protein 1 / metabolism
Sources: Web Of Science, ORCID
Added: August 6, 2018

2016 journal article

TRF2-Mediated Control of Telomere DNA Topology as a Mechanism for Chromosome-End Protection

Molecular Cell, 61(2), 274–286.

By: D. Benarroch-Popivker*, S. Pisano*, A. Mendez-Bermudez*, L. Lototska*, P. Kaur n, S. Bauwens*, N. Djerbi*, C. Latrick* ...

MeSH headings : Ataxia Telangiectasia Mutated Proteins / metabolism; Base Pairing; DNA / chemistry; DNA / metabolism; DNA Damage; DNA End-Joining Repair; HeLa Cells; Humans; Lysine / metabolism; Models, Molecular; Mutation; Nucleic Acid Conformation; Protein Structure, Tertiary; Shelterin Complex; Signal Transduction; Telomere / metabolism; Telomere-Binding Proteins / metabolism; Telomeric Repeat Binding Protein 2 / chemistry; Telomeric Repeat Binding Protein 2 / metabolism
Sources: Crossref, NC State University Libraries
Added: August 6, 2018

2016 journal article

Visualizing the Path of DNA through Proteins Using DREEM Imaging

MOLECULAR CELL, 61(2), 315–323.

MeSH headings : DNA / chemistry; DNA Mismatch Repair; Imaging, Three-Dimensional; Microscopy, Atomic Force; Nucleosomes / metabolism; Proteins / metabolism; Static Electricity
Source: Web Of Science
Added: August 6, 2018

2015 journal article

Comparison of Ensemble and Single Molecule Methods for Particle Characterization and Binding Analysis of a PEGylated Single-Domain Antibody

Journal of Pharmaceutical Sciences, 104(12), 4015–4024.

By: L. Schneeweis*, L. Obenauer-Kutner*, P. Kaur*, A. Yamniuk*, J. Tamura*, N. Jaffe*, B. O’Mara*, S. Lindsay*, M. Doyle*, J. Bryson*

author keywords: proteins; PEGylation; microscopy; light scattering (static); calorimetry (ITC)
MeSH headings : Antibodies / chemistry; Biological Assay / methods; Half-Life; Kinetics; Microscopy, Atomic Force / methods; Polyethylene Glycols / chemistry; Protein Binding / drug effects; Proteins / chemistry; Surface Plasmon Resonance / methods
Source: Crossref
Added: February 24, 2020

2015 journal article

Determining the DNA Diffusion Behavior of SA2 on Various DNA Substrates

Biophysical Journal, 108(2), 397a.

By: P. Countryman n, J. Lin n, P. Kaur n, E. Brennan n, H. Chen*, C. You*, J. Piehler*, Y. Tao*, H. Wang n

Sources: Crossref, ORCID
Added: February 24, 2020

2015 journal article

Enhanced Electrostatic Force Microscopy Imaging Reveals Mechanism of TRF2 Mediated DNA Compaction

Biophysical Journal, 108(2), 166a.

By: P. Kaur n

Source: Crossref
Added: December 31, 2020

2015 journal article

Revealing Structure and Dynamics of Telomere Maintenance Proteins on DNA: One Molecule at a Time

Biophysical Journal, 108(2), 7a.

By: H. Wang n, J. Lin n, P. Kaur n, P. Countryman n, P. Opresko*, S. Smith, J. Tao*

Sources: Crossref, ORCID
Added: February 24, 2020

2015 journal article

Single-Molecule Imaging Reveals Dynamics of SA1-TRF1 Interactions on Telomeric DNA

Biophysical Journal, 108(2), 206a.

By: J. Lin n, H. Chen*, P. Kaur n, W. Miao n, P. Countryman n, C. You*, J. Piehler*, Y. Tao*, S. Smith*, H. Wang n

Sources: Crossref, ORCID
Added: February 24, 2020

2014 journal article

Probing transient protein-mediated DNA linkages using nanoconfinement

Biomicrofluidics, 8(3), 034113.

By: M. Roushan n, P. Kaur n, A. Karpusenko n, P. Countryman n, C. Ortiz n, S. Fang Lim n, H. Wang n, R. Riehn n

Sources: Crossref, ORCID, NC State University Libraries
Added: August 6, 2018

2014 conference paper

Single-molecule imaging reveals DNA-binding properties of cohesin proteins SA1 and SA2.

Environmental and Molecular Mutagenesis, 55, S29–29.

By: J. Lin, P. Kaur, H. Chen, P. Countryman, M. Roushan, D. Flaherty, E. Brennan, C. You ...

Source: NC State University Libraries
Added: August 6, 2018

2014 journal article

Solution-state conformation and stoichiometry of yeast Sir3 heterochromatin fibres

Nature Communications, 5(1).

MeSH headings : Algorithms; Heterochromatin / chemistry; Heterochromatin / metabolism; Microscopy, Atomic Force; Monte Carlo Method; Nucleosomes / chemistry; Nucleosomes / genetics; Nucleosomes / metabolism; Protein Multimerization; Silent Information Regulator Proteins, Saccharomyces cerevisiae / chemistry; Silent Information Regulator Proteins, Saccharomyces cerevisiae / genetics; Silent Information Regulator Proteins, Saccharomyces cerevisiae / metabolism; Ultracentrifugation
Source: Crossref
Added: August 28, 2020

2014 journal article

TRF1 and TRF2 use different mechanisms to find telomeric DNA but share a novel mechanism to search for protein partners at telomeres

NUCLEIC ACIDS RESEARCH, 42(4), 2493–2504.

By: J. Lin n, P. Countryman n, N. Buncher n, P. Kaur n, E. Longjiang n, Y. Zhang n, G. Gibson n, C. You n ...

MeSH headings : DNA / chemistry; DNA / metabolism; Diffusion; Protein Binding; Protein Structure, Tertiary; Repetitive Sequences, Nucleic Acid; Telomere / chemistry; Telomere / metabolism; Telomeric Repeat Binding Protein 1 / metabolism; Telomeric Repeat Binding Protein 2 / chemistry; Telomeric Repeat Binding Protein 2 / metabolism
Source: Web Of Science
Added: August 6, 2018

2014 journal article

Unraveling secrets of telomeres: One molecule at a time

DNA REPAIR, 20, 142–153.

By: J. Lin n, P. Kaur n, P. Countryman n, P. Opresko* & H. Wang n

author keywords: Telomeres; Single-molecule imaging; Atomic force microscopy; Fluorescence microscopy; FRET; Laser tweezers; Magnetic tweezers; Protein DNA interactions
MeSH headings : Animals; Fluorescence Resonance Energy Transfer / methods; Humans; Microscopy, Atomic Force / methods; Microscopy, Fluorescence / methods; Optical Tweezers; Telomere / chemistry; Telomere / metabolism; Telomere-Binding Proteins / chemistry; Telomere-Binding Proteins / metabolism
Source: Web Of Science
Added: August 6, 2018

2013 journal article

DNA polymerase delta stalls on telomeric lagging strand templates independently from G-quadruplex formation

NUCLEIC ACIDS RESEARCH, 41(22), 10323–10333.

By: J. Lormand n, N. Buncher n, C. Murphy n, P. Kaur n, M. Lee n, P. Burgers n, H. Wang n, T. Kunkel n, P. Opresko n

MeSH headings : DNA / biosynthesis; DNA / chemistry; DNA Polymerase III / metabolism; G-Quadruplexes; Humans; Repetitive Sequences, Nucleic Acid; Telomere / metabolism; Templates, Genetic
Source: Web Of Science
Added: August 6, 2018

2013 review

Investigating bioconjugation by atomic force microscopy

[Review of ]. Journal of Anobiotechnology, 11.

By: I. Tessmer, P. Kaur, J. Lin & H. Wang

Source: NC State University Libraries
Added: August 6, 2018

2011 journal article

Antibody-Unfolding and Metastable-State Binding in Force Spectroscopy and Recognition Imaging

Biophysical Journal, 100(1), 243–250.

By: P. Kaur*, Qiang-Fu, A. Fuhrmann*, R. Ros*, L. Kutner*, L. Schneeweis*, R. Navoa*, K. Steger* ...

MeSH headings : Humans; Imaging, Three-Dimensional / methods; Immunoglobulin G / chemistry; Immunoglobulin G / metabolism; Kinetics; Protein Binding; Protein Conformation; Protein Unfolding; Spectrum Analysis / methods
Source: Crossref
Added: August 28, 2020