Piush Khanal

Works (7)

Updated: October 28th, 2024 08:14

2020 journal article

Evaluation of Resistance to Fescue Toxicosis in Purebred Angus Cattle Utilizing Animal Performance and Cytokine Response

TOXINS, 12(12).

By: D. Poole n , K. Mayberry n, M. Newsome n, R. Poole  n, J. Galliou n, P. Khanal n, M. Poore n, N. Serao  n

author keywords: fescue toxicosis; genetic tolerance; cytokines; cow productivity
MeSH headings : Animal Feed / analysis; Animal Feed / toxicity; Animals; Behavior, Animal / drug effects; Behavior, Animal / physiology; Cattle; Cattle Diseases / chemically induced; Cattle Diseases / metabolism; Cattle Diseases / microbiology; Cytokines / metabolism; Ergot Alkaloids / analysis; Ergot Alkaloids / toxicity; Herbivory / drug effects; Herbivory / physiology; Poaceae / microbiology; Poaceae / toxicity
TL;DR: Findings from this study support the proposed fescue toxicosis selection method, could accurately distinguish between tolerant and susceptible animals based on the performance parameters in cattle chronically exposed to ergot alkaloids, and provides evidence to warrant additional analysis to examine the impact of ergotAlkaloids on immune responsiveness in cattle experiencing fescues toxicosis. (via Semantic Scholar)
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Sources: Web Of Science, NC State University Libraries
Added: January 19, 2021

2020 journal article

Evaluation of a commercial genetic test for fescue toxicosis in pregnant Angus beef cattle

TRANSLATIONAL ANIMAL SCIENCE, 4(4).

By: J. Galliou n, P. Khanal n, K. Mayberry n, M. Poore n, D. Poole n  & N. Serao  n

author keywords: Bos taurus; Epichloe coenophiala; fescue toxicity; host genetics; T-Snip test
TL;DR: Results indicate that the T-Snip test may be predictive of cow performance (aBWd, aBCSd, and adjWW) in an endophyte-infected tall fescue environment. (via Semantic Scholar)
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Sources: Web Of Science, NC State University Libraries
Added: February 15, 2021

2020 journal article

Modeling host-microbiome interactions for the prediction of meat quality and carcass composition traits in swine

GENETICS SELECTION EVOLUTION, 52(1).

By: P. Khanal n, C. Maltecca n , C. Schwab, J. Fix*, M. Bergamaschi n & F. Tiezzi  n

Contributors: P. Khanal n, C. Maltecca n , C. Schwab, J. Fix*, M. Bergamaschi n & F. Tiezzi  n

MeSH headings : Animals; Female; Gastrointestinal Microbiome; Genome-Wide Association Study / methods; Host-Pathogen Interactions / genetics; Male; Metagenome; Models, Genetic; Polymorphism, Single Nucleotide; Pork Meat / standards; Quantitative Trait, Heritable; RNA, Ribosomal, 16S / genetics; Swine / genetics; Swine / microbiology
TL;DR: Inclusion of microbiome information in the model improved predictive ability of phenotypes for fat deposition and color traits whereas including a genome-by-microbiome term did not improve prediction accuracy significantly, providing novel insight on the use of microbiome Information for the phenotypic prediction of meat quality and carcass traits in swine. (via Semantic Scholar)
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Sources: Web Of Science, NC State University Libraries, ORCID
Added: August 24, 2020

2019 article

Evaluation of cytokine response as an indicator of genetic resistance to fescue toxicosis in purebred Angus cattle.

Mayberry, K., Poole, R. K., Newsome, M. K. A., Khanal, P., Poore, M. H., Serao, N. V. L., & Poole, D. H. (2019, July). JOURNAL OF ANIMAL SCIENCE, Vol. 97, pp. 45–46.

By: K. Mayberry n, R. Poole  n, M. Newsome n, P. Khanal n, M. Poore n, N. Serao *, D. Poole n 

author keywords: fescue toxicosis; genetic tolerance; cytokines
TL;DR: Evaluating the cytokine response of cows deemed either tolerant or susceptible to endophyte-infected fescue found greater concentrations of GASP-1, VEGF-A, and IL-4 in tolerant compared to susceptible cattle may mitigate the detrimental effects of fescUE toxicosis, including suppressed PRL and vasoconstriction, leading to improved animal performance in a fescues environment. (via Semantic Scholar)
Sources: Web Of Science, NC State University Libraries
Added: August 12, 2019

2019 article

Genes and functions associated with tolerance to fescue toxicosis in Angus cows

Khanal, P., Sanglard, L. P., Mayberry, K., Sommer, J., Poore, M. H., Poole, D. H., & Serao, N. V. L. (2019, July). JOURNAL OF ANIMAL SCIENCE, Vol. 97, pp. 167–167.

By: P. Khanal n, L. Sanglard*, K. Mayberry n, J. Sommer n, M. Poore n, D. Poole n , N. Serao *

author keywords: fescue toxicosis; differentially expressed genes; tolerance
TL;DR: Enrichment analysis showed that DEG between genetic groups have general functions, such as metabolic, biosynthetic, and catabolic processes, as well as DNA and RNA-related functions,such as translation, transcription, and repair. (via Semantic Scholar)
Sources: Web Of Science, NC State University Libraries
Added: August 12, 2019

2019 journal article

Genetic parameters of meat quality, carcass composition, and growth traits in commercial swine

JOURNAL OF ANIMAL SCIENCE, 97(9), 3669–3683.

By: P. Khanal n, C. Maltecca n , C. Schwab, K. Gray* & F. Tiezzi  n

Contributors: P. Khanal n, C. Maltecca n , C. Schwab, K. Gray* & F. Tiezzi  n

author keywords: carcass; genetic correlations; heritability; meat quality
MeSH headings : Animals; Body Composition / genetics; Body Weight / genetics; Breeding; Female; Genotype; Male; Parity / genetics; Phenotype; Red Meat / standards; Swine / genetics; Swine / growth & development; Swine / physiology
TL;DR: The genetic parameter estimates of this study indicate that a multi-trait approach should be considered for selection programs aimed at meat quality and carcass composition in commercial swine populations. (via Semantic Scholar)
Sources: Web Of Science, NC State University Libraries, ORCID
Added: November 4, 2019

2018 article

Evaluation of Angus Calf Performance Based on Dams Tolerance or Susceptibility to Fescue Toxicosis.

Mayberry, K., Khanal, P., Poore, M. H., Serao, N. V. L., & Poole, D. H. (2018, March). JOURNAL OF ANIMAL SCIENCE, Vol. 96, pp. 55–55.

By: K. Mayberry n, P. Khanal n, M. Poore n, N. Serao * & D. Poole n 

author keywords: calf performance; cow productivity; fescue toxicosis
Sources: Web Of Science, NC State University Libraries
Added: November 26, 2018

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