Works (17)
Updated: April 4th, 2024 15:19
2023 journal article
Facile hyperpolarization chemistry for molecular imaging and metabolic tracking of [1-13C]pyruvate in vivo
JOURNAL OF MAGNETIC RESONANCE OPEN, 16-17.
Contributors: K. MacCulloch n, A. Browning n, D. Guarin Bedoya, S. McBride n, M. Abdulmojeed n, C. Dedesma, B. Goodson *, M. Rosen *
author keywords: Hyperpolarized MRI; Parahydrogen; SABRE; Metabolic imaging
TL;DR:
A first demonstration of SABRE-hyperpolarized contrast detected in vivo, specifically using hyperpolarized [1-13C]pyruvate is described, illustrating the utility of combining lower-cost MRI systems with simple, low-cost hyperpolarization chemistry to develop safe, and scalable molecular imaging.
(via Semantic Scholar)
open access via doi.org (publisher)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
6. Clean Water and Sanitation
(OpenAlex)
Sources: Web Of Science, NC State University Libraries, ORCID
Added: November 15, 2023
2023 article
Parahydrogen in Reversible Exchange Induces Long-Lived 15N Hyperpolarization of Anticancer Drugs Anastrozole and Letrozole
MacCulloch, K., Browning, A., TomHon, P., Lehmkuhl, S., Chekmenev, E. Y., & Theis, T. (2023, May 10). ANALYTICAL CHEMISTRY, Vol. 5.
Contributors: K. MacCulloch n, A. Browning n, n , S. Lehmkuhl n, E. Chekmenev * & T. Theis n
MeSH headings : Letrozole; Anastrozole; Magnetic Resonance Spectroscopy; Magnetic Resonance Imaging; Antineoplastic Agents / pharmacology
TL;DR:
The nitrile 15N sites enable long-lasting polarization storage with [15N]T1 over 9 min, enabling signal detection from a single hyperpolarization cycle for over 30 min, and this sensitivity gain enables polarization studies at naturally abundant 15N enrichment level (0.4%).
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, NC State University Libraries, ORCID
Added: May 11, 2023
2023 journal article
Spin dynamics of [1,2-C-13(2)]pyruvate hyperpolarization by parahydrogen in reversible exchange at micro Tesla fields
PHYSICAL CHEMISTRY CHEMICAL PHYSICS, 25(24), 16446–16458.
Contributors: A. Browning n, K. Macculloch n, n , I. Mandzhieva n, E. Chekmenev *, B. Goodson *, S. Lehmkuhl n, T. Theis n
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, NC State University Libraries, ORCID
Added: June 13, 2023
2022 article
Catalyst-Free Aqueous Hyperpolarized [1-13C]Pyruvate Obtained by Re-Dissolution Signal Amplification by Reversible Exchange
Schmidt, A. B., Maissin, H., Adelabu, I., Nantogma, S., Ettedgui, J., TomHon, P., … Chekmenev, E. Y. (2022, November 15). ACS SENSORS, Vol. 11.
Contributors: A. Schmidt *, H. De Maissin *, I. Adelabu *, S. Nantogma *, J. Ettedgui*, n , B. Goodson *, T. Theis n , E. Chekmenev *
author keywords: Biosensors; magnetic resonance imaging; hyperpolarization; imaging agents; NMR spectroscopy; Parahydrogen; Pyruvate; SABRE
MeSH headings : Humans; Pyruvic Acid; Magnetic Resonance Spectroscopy / methods; Solubility; Magnetic Resonance Imaging / methods; Water
TL;DR:
The development of Re-Dissolution Signal Amplification By Reversible Exchange (Re-D SABRE), which relies on fast and low-cost hyperpolarization of [1-13C]pyruvate by chemical exchange with parahydrogen at microtesla magnetic fields, is reported.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: ORCID, Web Of Science, NC State University Libraries
Added: November 16, 2022
2022 article
Interplay of Near-Zero-Field Dephasing, Rephasing, and Relaxation Dynamics and [1-C-13]Pyruvate Polarization Transfer Efficiency in Pulsed SABRE-SHEATH
Nantogma, S., Eriksson, S. L., Adelabu, I., Mandzhieva, I., Browning, A., TomHon, P., … Chekmenev, E. Y. (2022, November 28). JOURNAL OF PHYSICAL CHEMISTRY A, Vol. 11.
Contributors: S. Nantogma *, S. Eriksson *, I. Adelabu *, I. Mandzhieva n, A. Browning n, n , W. Warren *, T. Theis n , B. Goodson *, E. Chekmenev *
MeSH headings : Pyruvic Acid
TL;DR:
The application of microtesla pulses is studied to investigate their effect on C-13 polarization efficiency, compared to that of conventional SABRE-SHEATH employing a static field, to provide the matching conditions of polarization transfer from parahydrogen-derived hydrides to the 13C-1 nucleus.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: ORCID, Web Of Science, NC State University Libraries
Added: November 29, 2022
2022 article
Triplet Photosensitized para-Hydrogen Induced Polarization
Brown, E. E., Mandzhieva, I., TomHon, P. M., Theis, T., & Castellano, F. N. (2022, November 14). ACS CENTRAL SCIENCE, Vol. 11.
Contributors: E. Brown n , I. Mandzhieva n, n , T. Theis n & F. Castellano n
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: ORCID, Web Of Science, NC State University Libraries
Added: November 15, 2022
2021 article
A Versatile Compact Parahydrogen Membrane Reactor
TomHon, P. M., Han, S., Lehmkuhl, S., Appelt, S., Chekmenev, E. Y., Abolhasani, M., & Theis, T. (2021, October 26). CHEMPHYSCHEM, Vol. 10.
Contributors: n , S. Han n, S. Lehmkuhl n, S. Appelt *, E. Chekmenev *, M. Abolhasani n , T. Theis n
author keywords: hyperpolarization; parahydrogen; NMR; fluidics; RASER
MeSH headings : Magnetic Resonance Imaging; Magnetic Resonance Spectroscopy
TL;DR:
A Spin Transfer Automated Reactor that produces continuous parahydrogen induced polarization (PHIP), which is stable for hours to days is introduced, and the PHIP variant called signal amplification by reversible exchange (SABRE) is used, which is particularly well suited to produce continuous hyperpolarization.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, NC State University Libraries, ORCID
Added: November 8, 2021
2021 article
Density Functional Theory Study of Reaction Equilibria in Signal Amplification by Reversible Exchange
Lin, K., TomHon, P., Lehmkuhl, S., Laasner, R., Theis, T., & Blum, V. (2021, September 22). CHEMPHYSCHEM, Vol. 9.
Contributors: K. Lin *, n , S. Lehmkuhl n, R. Laasner *, T. Theis n & V. Blum *
author keywords: computational chemistry; density functional calculations; hyperpolarization; NMR spectroscopy; reaction mechanisms; parahydrogen
MeSH headings : Density Functional Theory; Hydrogen / chemistry; Methanol / chemistry; Pyridines / chemistry; Surface Properties
TL;DR:
An in-depth theoretical analysis of key chemical equilibria in Signal Amplification by Reversible Exchange (SABRE), employing density functional theory calculations to characterize the likely reaction network, shows that a methanol-containing intermediate is plausible as a transient species in the process.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
7. Affordable and Clean Energy
(OpenAlex)
Sources: ORCID, Web Of Science, NC State University Libraries
Added: September 23, 2021
2021 article
Density Functional Theory Study of Reaction Equilibria in Signal Amplification by Reversible Exchange
Lin, K., TomHon, P., Lehmkuhl, S., Laasner, R., Theis, T., & Blum, V. (2021, October 5). CHEMPHYSCHEM, Vol. 22, pp. 1937–1938.
Contributors: K. Lin *, n , S. Lehmkuhl n, R. Laasner *, T. Theis n & V. Blum *
author keywords: computational chemistry; density functional calculations; hyperpolarization; NMR spectroscopy; reaction mechanisms; parahydrogen
TL;DR:
The front cover artwork is provided by the groups of Prof. Thomas Theis and Volker Blum and shows the reaction network of Signal Amplification by Reversible Exchange, elucidated by density functional theory (DFT).
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: ORCID, Web Of Science, NC State University Libraries
Added: October 10, 2021
2021 journal article
Front Cover: Density Functional Theory Study of Reaction Equilibria in Signal Amplification by Reversible Exchange (ChemPhysChem 19/2021)
ChemPhysChem.
Source: ORCID
Added: October 10, 2021
2021 article
Hyperpolarization of common antifungal agents with SABRE
MacCulloch, K., Tomhon, P., Browning, A., Akeroyd, E., Lehmkuhl, S., Chekmenev, E. Y., & Theis, T. (2021, June 20). MAGNETIC RESONANCE IN CHEMISTRY, Vol. 6.
Contributors: K. MacCulloch n, n , A. Browning n, E. Akeroyd n, S. Lehmkuhl n, E. Chekmenev *, T. Theis n
author keywords: N-15; H-1; antifungals; clotrimazole and fluconazole; contrast agents; hyperpolarization; NMR; parahydrogen; SABRE; voriconazole
MeSH headings : Antifungal Agents; Catalysis; Magnetic Resonance Imaging; Magnetic Resonance Spectroscopy; Nitrogen Isotopes
TL;DR:
This work broadens the SABRE substrate scope and provides mechanistic and kinetic insights into the HP process, optimizing the polarization with respect to temperature and the polarization transfer field (PTF) for 1 H nuclei in the millitesla regime and for 15 N nucleiIn the microtesla regime, which provides detailed insights into exchange kinetics and spin evolution.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, ORCID, NC State University Libraries
Added: June 21, 2021
2021 journal article
Intensified continuous extraction of switchable hydrophilicity solvents triggered by carbon dioxide
GREEN CHEMISTRY, 23(8), 2900–2906.
Contributors: S. Han n, M. Ramezani n, n , K. Abdel-Latif n, R. Epps n , T. Theis n , M. Abolhasani n
Sources: Web Of Science, ORCID, NC State University Libraries
Added: April 1, 2021
2021 journal article
Micron-Scale NV-NMR Spectroscopy with Signal Amplification by Reversible Exchange
PRX Quantum, 2(1), 010305.
Contributors: N. Arunkumar*, D. Bucher *, M. Turner *, n , D. Glenn*, S. Lehmkuhl n, M. Lukin *, H. Park *
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, NC State University Libraries, ORCID, Crossref
Added: January 13, 2021
2021 article
Order-Unity C-13 Nuclear Polarization of [1-C-13]Pyruvate in Seconds and the Interplay of Water and SABRE Enhancement
Adelabu, I., TomHon, P., Kabir, M. S. H., Nantogma, S., Abdulmojeed, M., Mandzhieva, I., … Chekmenev, E. Y. (2021, December 9). CHEMPHYSCHEM, Vol. 11.
Contributors: I. Adelabu *, n , M. Kabir *, S. Nantogma *, M. Abdulmojeed n, I. Mandzhieva n, J. Ettedgui*, R. Swenson *
author keywords: hyperpolarization; NMR spectroscopy; parahydrogen; C-13; pyruvate
MeSH headings : Magnetic Resonance Imaging; Magnetic Resonance Spectroscopy; Nitrogen Isotopes; Pyruvic Acid; Water / chemistry
TL;DR:
Signal Amplification By Reversible Exchange in SHield Enabled Alignment Transfer (SABRE-SHEATH) is investigated to achieve rapid hyperpolarization of 13C1 spins of [1-13C]pyruvate, using parahydrogen as the source of nuclear spin order.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
6. Clean Water and Sanitation
(OpenAlex)
Sources: ORCID, Web Of Science, NC State University Libraries
Added: December 10, 2021
2021 article
Temperature Cycling Enables Efficient 13C SABRE-SHEATH Hyperpolarization and Imaging of [1-13C]Pyruvate
TomHon, P., Abdulmojeed, M., Adelabu, I., Nantogma, S., Kabir, M. S. H., Lehmkuhl, S., … Theis, T. (2021, August 2). ChemRxiv.
Contributors: n , M. Abdulmojeed n, I. Adelabu *, S. Nantogma *, M. Kabir *, S. Lehmkuhl n, E. Chekmenev *, T. Theis n
Source: ORCID
Added: February 2, 2022
2021 article
Temperature Cycling Enables Efficient C-13 SABRE-SHEATH Hyperpolarization and Imaging of [1-C-13]-Pyruvate
TomHon, P., Abdulmojeed, M., Adelabu, I., Nantogma, S., Kabir, M. S. H., Lehmkuhl, S., … Theis, T. (2021, December 23). JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, Vol. 12.
Contributors: n , M. Abdulmojeed n, I. Adelabu *, S. Nantogma *, M. Kabir *, S. Lehmkuhl n, E. Chekmenev *, T. Theis n
MeSH headings : Pyruvic Acid
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
9. Industry, Innovation and Infrastructure
(OpenAlex)
Sources: ORCID, Web Of Science, NC State University Libraries
Added: December 24, 2021
2020 journal article
Automated pneumatic shuttle for magnetic field cycling and parahydrogen hyperpolarized multidimensional NMR
Journal of Magnetic Resonance, 312, 106700.
Contributors: n , E. Akeroyd n, S. Lehmkuhl n, E. Chekmenev * & T. Theis n
author keywords: Parahydrogen; SABRE; Magnetic field cycling; Pneumatic shuttling; Singlet states; Hyperpolarization
MeSH headings : Catalysis; Equipment Design; Hydrogen / chemistry; Magnetic Fields; Magnetic Resonance Spectroscopy / instrumentation; Models, Molecular; Nitrogen Isotopes / chemistry; Protons
TL;DR:
A simple-to-implement pneumatic sample shuttle system that enables automated 2D hyperpolarized NMR, including the first inverse 15N/1H HSQC, and uncovers binding mechanisms of the catalytic species through cross peaks that are not accessible in standard one-dimensional hyperPolarized experiments.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, ORCID, NC State University Libraries, Crossref
Added: March 23, 2020
Employment
Updated: February 19th, 2020 17:38
2018 - present
North Carolina State University Raleigh, North Carolina, US
Graduate Student
Department of Chemistry
Education
Updated: April 27th, 2021 14:11
2018 - present
North Carolina State University Raleigh, North Carolina, US
Ph.D. Candidate
Physical Chemistry
2014 - 2019
University of Richmond Richmond, Virginia, US
B.S.
Chemistry
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