Works (46)
Updated: November 5th, 2024 10:00
2024 journal article
Myeloid cell MHC I expression drives CD8<SUP>+</SUP> T cell activation in nonalcoholic steatohepatitis
FRONTIERS IN IMMUNOLOGY, 14.
Contributors: T. Williams n , V. Adams n, L. Collins n , J. Holmes n, n , H. Atkins n, G. Scheidemantle n, X. Liu n
Ed(s): T. Williams n , L. Collins n & A. Kennedy n
author keywords: liver; NASH; fibrosis; H2Kb; CD8(+) T cells; immunopeptidome
TL;DR:
Activated hepatic CD8+ T cells are dependent on myeloid cell MHC class I expression in diet induced NASH to promote inflammation and fibrosis and a role of NADPH oxidase in the production of Ncf2 peptide generation is suggested.
(via Semantic Scholar)
open access via www.frontiersin.org (publisher PDF)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, NC State University Libraries, ORCID
Added: January 28, 2024
2023 journal article
A Kmer-based paired-end read de novo assembler and genotyper for canine MHC class I genotyping
ISCIENCE, 26(2).
TL;DR:
A Kmer-based paired-end read (KPR) de novo assembler and genotyper, which assemble paired- end RNA-seq reads from MHC-I regions into contigs, and then genotype each contig and estimate its expression level meets a significant need in biomedical research.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, NC State University Libraries
Added: June 12, 2023
2022 journal article
Doxorubicin for treatment of histiocytic sarcoma in dogs: 31 cases (2003-2017)
JAVMA-JOURNAL OF THE AMERICAN VETERINARY MEDICAL ASSOCIATION, 260(14), 1827–1833.
MeSH headings : Dogs; Animals; Histiocytic Sarcoma / veterinary; Retrospective Studies; Dog Diseases / diagnosis; Doxorubicin / therapeutic use; Treatment Outcome
TL;DR:
Benefits of doxorubicin administration in canine HS are modest, with a limited ORR and delay in tumor progression, and are comparable to effects attained with other single-agent regimens.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
1. No Poverty
(OpenAlex)
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, NC State University Libraries
Added: February 6, 2023
2021 journal article
Dog leukocyte antigen-88*034:01 presents nonamer peptides from canine distemper virus hemagglutinin, large polymerase, and matrix proteins
HLA, 97(5), 428–434.
author keywords: distemper virus; canine; dogs; epitopes; major histocompatibility complex; peptides; T-lymphocytes; cytotoxic
MeSH headings : Alleles; Animals; Distemper Virus, Canine / genetics; Dogs; Hemagglutinins; Leukocytes; Peptides
TL;DR:
The allomorph's binding motif is experimentally confirmed by developing an MHC surface stabilization assay, which adds new tools for studying neoepitope‐specific CTL in Boxers to foster canine comparative oncology.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
Sources: ORCID, Web Of Science, NC State University Libraries
Added: February 4, 2021
2021 article
High-resolution characterization of the structural features and genetic variation of six feline leukocyte antigen class I loci via single molecule, real-time (SMRT) sequencing
Holmes, J. C., Scholl, E. H., Dickey, A. N., & Hess, P. R. (2021, June 27). IMMUNOGENETICS, Vol. 6.
author keywords: Cats; Class I genes; High-throughput DNA sequencing; Major histocompatibility complex; Polymorphism
MeSH headings : Animals; Cats; Exons; Genes, MHC Class I / genetics; Genetic Variation; Haplotypes; High-Throughput Nucleotide Sequencing; Histocompatibility Antigens Class I / chemistry; Histocompatibility Antigens Class I / genetics; Sequence Analysis, DNA / methods
TL;DR:
A targeted approach to FLAI genotyping, using the single-molecule real-time (SMRT) platform, which allows full-length (3.4-kb) reads without assembly, is developed, which could allow highly accurate allele surveys in large cat cohorts.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, NC State University Libraries
Added: July 6, 2021
2019 journal article
Cancer‐testis antigens in canine histiocytic sarcoma and other malignancies
Veterinary and Comparative Oncology, 17(3), 317–328.
author keywords: cancer-testis antigens; dog; histiocytic sarcoma; mass spectrometry; MHC class I
MeSH headings : Animals; Antigens, Neoplasm / metabolism; Cell Line, Tumor; Chromatography, Liquid; Dog Diseases / metabolism; Dogs; Gene Expression Regulation, Neoplastic / physiology; HLA Antigens / metabolism; Histiocytic Sarcoma / genetics; Histiocytic Sarcoma / metabolism; Humans; Male; RNA, Messenger / genetics; RNA, Messenger / metabolism; Tandem Mass Spectrometry; Testis / metabolism
TL;DR:
The results illustrate the feasibility of discovering canine CTAs by a reverse approach, proceeding from identification of MHC class I-presented peptides to a comparative RNA expression survey of tumours and normal tissues.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
Sources: Crossref, ORCID, NC State University Libraries
Added: July 20, 2019
2019 journal article
Incidence and risk factors associated with development of clinical cardiotoxicity in dogs receiving doxorubicin
Journal of Veterinary Internal Medicine, 33(2), 783–791.
author keywords: canine; cardiology; cardiomyopathy; chemotherapy; echocardiography; oncology
MeSH headings : Animals; Antibiotics, Antineoplastic / administration & dosage; Antibiotics, Antineoplastic / adverse effects; Antibiotics, Antineoplastic / therapeutic use; Body Weight; Cardiomyopathy, Dilated / veterinary; Cardiotoxicity / veterinary; Dog Diseases / drug therapy; Dogs; Doxorubicin / administration & dosage; Doxorubicin / adverse effects; Doxorubicin / therapeutic use; Female; Heart Diseases / chemically induced; Heart Diseases / veterinary; Incidence; Male; Neoplasms / drug therapy; Neoplasms / veterinary; Retrospective Studies; Risk Factors
TL;DR:
Overall, the incidence of clinical DOX‐induced cardiotoxicity is low, but Boxers and other breeds at high risk for dilated cardiomyopathy may be at an increased risk.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
Sources: Web Of Science, ORCID, NC State University Libraries, Crossref
Added: April 22, 2019
2018 journal article
The canine MHC class Ia allele DLA-88*508:01 presents diverse self- and canine distemper virus-origin peptides of varying length that have a conserved binding motif
Veterinary Immunology and Immunopathology, 197, 76–86.
author keywords: Canine distemper virus; CD8(+) T lymphocytes; MHC; Peptides/Epitopes; Retrovirus
MeSH headings : Alleles; Amino Acid Motifs; Animals; Antigen Presentation; Distemper Virus, Canine / chemistry; Distemper Virus, Canine / immunology; Dogs / genetics; Epitopes / chemistry; Epitopes / immunology; Genes, MHC Class I; Histocompatibility Antigens Class I / genetics; Histocompatibility Antigens Class I / immunology; Peptides / chemistry; Peptides / immunology; Protein Binding; T-Lymphocytes / immunology; Viral Proteins / chemistry; Viral Proteins / immunology
TL;DR:
The presentation of diverse self and viral peptides indicates that DLA-88 is a classical MHC class Ia gene, and thus, potential targets of anti-viral CTL in D LA-88*508:01-bearing dogs.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Crossref, ORCID, NC State University Libraries
Added: July 20, 2019
2018 journal article
The prevalent Boxer MHC class Ia allotype dog leukocyte antigen (DLA)-88*034:01 preferentially binds nonamer peptides with a defined motif
HLA, 92(6), 403–407.
author keywords: amino acids; binding motif; dogs; MHC class I; peptides; tandem mass spectrometry
MeSH headings : Amino Acid Motifs; Amino Acids / chemistry; Amino Acids / immunology; Animals; Antigens, Neoplasm / analysis; Antigens, Neoplasm / genetics; Antigens, Neoplasm / immunology; Dogs; Epitopes / chemistry; Epitopes / genetics; Epitopes / immunology; Gene Expression; Histocompatibility Antigens Class I / chemistry; Histocompatibility Antigens Class I / genetics; Histocompatibility Antigens Class I / immunology; Oligopeptides / chemistry; Oligopeptides / genetics; Oligopeptides / immunology; Protein Binding; T-Lymphocytes / chemistry; T-Lymphocytes / immunology; Tandem Mass Spectrometry
TL;DR:
Mass spectrometry of eluted peptides showed a preference for nonamers with conserved amino acid preferences that should expedite finding epitopes restricted by this DLA‐88 allotype, which is popular, inbred dogs with increased risks of relevant target cancers and restricted MHC diversity.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
Sources: Web Of Science, ORCID, NC State University Libraries, Crossref
Added: January 14, 2019
2017 journal article
Canine scent detection of canine cancer: A feasibility study
Veterinary Medicine-Research and Reports, 8, 1–7.
Source: NC State University Libraries
Added: August 6, 2018
2017 journal article
Canine scent detection of canine cancer: a feasibility study
Veterinary Medicine: Research and Reports, Volume 8, 69–76.
author keywords: urinary tract cancer; cancer detection dogs; cancer odor; olfactory memory; multiple sample learning
TL;DR:
The study illustrates the need to consider canine olfactory memory and the use of double-blind methods to avoid erroneous conclusions regarding the ability of dogs to alert on specimens from canine cancer patients and suggests that sample storage, confounding odors, and other factors need to be considered in the design of future studies that evaluate the detection of canine cancers by scent detection dogs.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
10. Reduced Inequalities
(OpenAlex)
Sources: ORCID, Crossref
Added: July 21, 2019
2017 journal article
Oral melphalan for the treatment of relapsed canine lymphoma
Veterinary and Comparative Oncology, 16(1), E123–E129.
author keywords: canine; chemotherapy; lymphoma; melphalan; rescue
MeSH headings : Administration, Oral; Animals; Antineoplastic Agents, Alkylating / administration & dosage; Antineoplastic Agents, Alkylating / adverse effects; Antineoplastic Agents, Alkylating / therapeutic use; Dog Diseases / drug therapy; Dogs; Female; Lymphoma / drug therapy; Lymphoma / veterinary; Male; Melphalan / administration & dosage; Melphalan / adverse effects; Melphalan / therapeutic use; Recurrence; Retrospective Studies
TL;DR:
Although treatment resulted in limited clinical benefit and non-durable responses, oral melphalan was well-tolerated and may be a reasonable rescue option in cases where minimal effective agents remain.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
Sources: Web Of Science, ORCID, NC State University Libraries, Crossref
Added: August 6, 2018
2017 journal article
Saporin-conjugated tetramers identify efficacious anti-HIV CD8+ T-cell specificities.
PloS One.
MeSH headings : Antiviral Agents / pharmacology; CD8-Positive T-Lymphocytes / drug effects; CD8-Positive T-Lymphocytes / immunology; Endocytosis / drug effects; HIV Infections / drug therapy; HIV Infections / immunology; Humans; Lymphocyte Depletion; Protein Multimerization; Ribosome Inactivating Proteins, Type 1 / therapeutic use; Saporins
TL;DR:
The utility of cytotoxic saporin-conjugated tetramers is demonstrated here in identifying the CD8+ T-cell specificity most effective in preventing HIV progression in HIV-infected HLA-B*27-positive immune controllers.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
Source: ORCID
Added: September 9, 2019
2017 journal article
Saporin-conjugated tetramers identify efficacious anti-HIV CD8+T-cell specificities
PLoS One, 12(10).
Source: NC State University Libraries
Added: August 6, 2018
2016 journal article
Canine acute leukaemia: 50 cases (1989-2014)
Veterinary and Comparative Oncology, 15(3), 1101–1114.
author keywords: acute leukaemia; canine; chemotherapy; CHOP; immunophenotype
MeSH headings : Acute Disease; Animals; Antineoplastic Agents / adverse effects; Antineoplastic Agents / therapeutic use; Dog Diseases / drug therapy; Dog Diseases / mortality; Dogs; Leukemia / drug therapy; Leukemia / mortality; Leukemia / veterinary; Retrospective Studies; Survival Analysis; Treatment Outcome
TL;DR:
Most dogs developed chemoresistance within weeks of initiating treatment, and consequently, survival times for AL remain disappointingly short.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, ORCID, NC State University Libraries, Crossref
Added: August 6, 2018
2013 journal article
Characterization and allelic variation of the transporters associated with antigen processing (TAP) genes in the domestic dog (Canis lupus familiaris)
Developmental & Comparative Immunology, 41(4), 578–586.
author keywords: Alleles; Canine; Immunology; Splice variants; Transporter associated with antigen processing
MeSH headings : ATP-Binding Cassette Transporters / genetics; Alleles; Amino Acid Sequence; Animals; Antigen Presentation / genetics; Cell Line; Dogs; Genetic Variation; Histocompatibility Antigens Class I / genetics; Humans; Mice; Molecular Sequence Data; Phylogeny; Promoter Regions, Genetic; Protein Isoforms; Wolves / genetics
TL;DR:
The promoter and coding regions of the canine TAP1 and TAP2 genes, which encode the homologous subunits forming the TAP heterodimer, are reported, which should prove useful in investigating the association of specific TAP defects or alleles with immunity to intracellular pathogens and cancer in dogs.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, Crossref, ORCID, NC State University Libraries
Added: August 6, 2018
2013 journal article
Comparison of automated versus manual neutrophil counts for the detection of cellular abnormalities in dogs receiving chemotherapy: 50 cases (May to June 2008)
JAVMA-JOURNAL OF THE AMERICAN VETERINARY MEDICAL ASSOCIATION, 242(11), 1539–1543.
Contributors: M. Cora n, J. Neel* , C. Grindem*, G. Kissling & *
MeSH headings : Animals; Antineoplastic Agents / adverse effects; Antineoplastic Agents / therapeutic use; Dog Diseases / blood; Dog Diseases / drug therapy; Dogs; Neoplasms / drug therapy; Neoplasms / veterinary; Neutropenia / chemically induced; Neutropenia / diagnosis; Neutropenia / veterinary; Neutrophils / physiology; Retrospective Studies
TL;DR:
An automated CBC appears to be accurate for neutrophil counts, but a microscopic examination of the corresponding blood smear is still recommended; further studies are needed to determine whether the detection or frequency of these abnormalities would differ dependent on chemotherapy protocol, neoplastic disease, and decision thresholds used by the oncologist in the ordering of a CBC without a blood smear evaluation.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, ORCID, NC State University Libraries
Added: August 6, 2018
2013 journal article
Deletion of naïve T cells recognizing the minor histocompatibility antigen HY with toxin-coupled peptide-MHC class I tetramers inhibits cognate CTL responses and alters immunodominance
Transplant Immunology, 29(1-4), 138–145.
author keywords: Cytotoxic T lymphocytes; Alloreactivity; MHC; Tetramers; Minor histocompatibility antigens; Immunodominance
MeSH headings : Allografts; Animals; Bone Marrow Transplantation; CD8-Positive T-Lymphocytes / immunology; Epitopes, T-Lymphocyte / genetics; Epitopes, T-Lymphocyte / immunology; Female; H-Y Antigen / genetics; H-Y Antigen / immunology; Histocompatibility Antigens Class I / genetics; Histocompatibility Antigens Class I / immunology; Histocompatibility Antigens Class I / pharmacology; Immunotoxins / genetics; Immunotoxins / immunology; Immunotoxins / pharmacology; Lymphocyte Depletion / methods; Male; Mice; Mice, Transgenic; Peptides / genetics; Peptides / immunology; Peptides / pharmacology
TL;DR:
As hypothesized, toxic tetramer administration prior to immunization increased survival of cognate peptide-pulsed cells in an in vivo CTL assay, and reduced the frequency of corresponding T cells, however, tetramer-mediated decreases in either T-cell population magnified CTL responses against the non-targeted epitope, suggesting that D(b)-Uty(+) and D( b)-Smcy(+) T cells compete for a limited common resource during priming.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, ORCID, NC State University Libraries, Crossref
Added: August 6, 2018
2013 journal article
Podoplanin maintains high endothelial venule integrity by interacting with platelet CLEC-2
Nature, 502(7469), 105–109.
MeSH headings : Animals; Antigens, CD / metabolism; Cadherins / metabolism; Endothelium, Lymphatic / immunology; Endothelium, Lymphatic / metabolism; Female; Gene Expression Regulation; Intercellular Junctions / genetics; Intercellular Junctions / immunology; Lectins, C-Type / metabolism; Lymph Nodes / metabolism; Lymph Nodes / pathology; Lysophospholipids / metabolism; Male; Membrane Glycoproteins / genetics; Membrane Glycoproteins / metabolism; Mice; Mice, Inbred C57BL; Sphingosine / analogs & derivatives; Sphingosine / metabolism
TL;DR:
A role for the transmembrane O-glycoprotein podoplanin (PDPN) in maintaining HEV barrier function is reported and local sphingosine-1-phosphate release after PDPN–CLEC-2-mediated platelet activation is critical for HEV integrity during immune responses.
(via Semantic Scholar)
Sources: Crossref, NC State University Libraries
Added: September 6, 2020
2013 journal article
Polymorphisms and tissue expression of the feline leukocyte antigen class I loci FLAI-E, FLAI-H, and FLAI-K
Immunogenetics, 65(9), 675–689.
author keywords: Cat; Major histocompatibility complex; Polymorphism; Classical class I genes
MeSH headings : Amino Acid Sequence; Animals; CD8-Positive T-Lymphocytes / immunology; Cats / genetics; Cats / immunology; Cloning, Molecular; Complementarity Determining Regions / genetics; Genotype; Histocompatibility Antigens Class I / chemistry; Histocompatibility Antigens Class I / genetics; Models, Animal; Molecular Sequence Data; Polymorphism, Single Nucleotide; Sequence Alignment; Viruses / immunology
TL;DR:
Alleles could be assigned to a specific locus with reasonable confidence, although there was evidence of potentially confounding interlocus recombination between FLAI-E andFLAI-K, and hypervariable regions across these genes permitted the assignment of names to both novel and established alleles.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, ORCID, NC State University Libraries, Crossref
Added: August 6, 2018
2012 journal article
A cell-based MHC stabilization assay for the detection of peptide binding to the canine classical class I molecule, DLA-88
VETERINARY IMMUNOLOGY AND IMMUNOPATHOLOGY, 150(3-4), 206–212.
author keywords: Canine; CD8(+) T lymphocytes; MHC; Peptides/epitopes
MeSH headings : Animals; Biological Assay / methods; Biological Assay / veterinary; CD8-Positive T-Lymphocytes / metabolism; Cell Line, Tumor; Cell Membrane; Dogs / metabolism; Epitopes; Gene Expression Regulation / physiology; Histocompatibility Antigens Class I / chemistry; Histocompatibility Antigens Class I / metabolism; Mice; Protein Binding; Protein Subunits
TL;DR:
The potential to use RMA-S cells transfected with canine alleles as a tool for CTL epitope discovery in this species is demonstrated, and the high false positive rate with this analysis ideally requires binding confirmation.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, ORCID, NC State University Libraries
Added: August 6, 2018
2012 journal article
Allelic diversity at the DLA-88 locus in Golden Retriever and Boxer breeds is limited
TISSUE ANTIGENS, 80(2), 175–183.
author keywords: breeds; canine; class I genes; major histocompatibility complex; polymorphisms
MeSH headings : Alleles; Amino Acid Sequence; Animals; Breeding; CD8-Positive T-Lymphocytes / cytology; CD8-Positive T-Lymphocytes / immunology; CD8-Positive T-Lymphocytes / metabolism; Dogs / genetics; Dogs / immunology; Gene Frequency; Genetic Loci; Haplotypes; Histocompatibility Antigens Class I / genetics; Histocompatibility Antigens Class I / immunology; Homozygote; Models, Molecular; Molecular Sequence Data; Phylogeny; Polymorphism, Genetic; Sequence Alignment
TL;DR:
The finding of highly prevalent alleles fulfills an important prerequisite for studying canine CD8+ T-cell responses and represents a significant advance over previous analyses of major histocompatibility complex class I genes.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, ORCID, NC State University Libraries
Added: August 6, 2018
2012 journal article
Chronic lymphocytic leukaemia in the cat: 18 cases (2000-2010)
Veterinary and Comparative Oncology, 11(4), 256–264.
author keywords: blood; feline; lymphocytosis; neoplasm; oncology
MeSH headings : Animals; Antineoplastic Agents / adverse effects; Antineoplastic Agents / therapeutic use; Cat Diseases / pathology; Cats; Female; Leukemia, Lymphocytic, Chronic, B-Cell / diagnosis; Leukemia, Lymphocytic, Chronic, B-Cell / drug therapy; Leukemia, Lymphocytic, Chronic, B-Cell / pathology; Leukemia, Lymphocytic, Chronic, B-Cell / veterinary; Male; Retrospective Studies
TL;DR:
Results of this study suggest that CLL affects older-aged cats and responds favourably to treatment with oral chlorambucil and prednisolone and to multi-agent injectable chemotherapy.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
Sources: Web Of Science, ORCID, NC State University Libraries, Crossref
Added: August 6, 2018
2012 journal article
Development of an ELISA to detect circulating anti-asparaginase antibodies in dogs with lymphoid neoplasia treated with Escherichia colil-asparaginase
Veterinary and Comparative Oncology, 13(2), 77–88.
author keywords: antibodies; canine; ELISA; L-asparaginase; lymphoma
MeSH headings : Animals; Antibodies / blood; Antineoplastic Agents / immunology; Antineoplastic Agents / therapeutic use; Asparaginase / immunology; Asparaginase / therapeutic use; Dog Diseases / blood; Dog Diseases / drug therapy; Dog Diseases / immunology; Dogs; Enzyme-Linked Immunosorbent Assay / veterinary; Escherichia coli / enzymology; Immunoglobulin G / blood; Lymphoma / blood; Lymphoma / drug therapy; Lymphoma / immunology; Lymphoma / veterinary; Reproducibility of Results; Sensitivity and Specificity
TL;DR:
An enzyme-linked immunosorbent assay (ELISA) to measure plasma anti-asparaginase immunoglobulin G responses should prove useful in investigating the potential correlation of antibody responses with resistance.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
Sources: Web Of Science, ORCID, NC State University Libraries, Crossref
Added: August 6, 2018
2012 journal article
Making the Most of Major Histocompatibility Complex Molecule Multimers: Applications in Type 1 Diabetes
Clinical and Developmental Immunology, 2012, 1–9.
MeSH headings : Animals; CD4-Positive T-Lymphocytes / immunology; CD8-Positive T-Lymphocytes / immunology; Diabetes Mellitus, Type 1 / immunology; Diabetes Mellitus, Type 1 / therapy; Histocompatibility Antigens Class I / immunology; Histocompatibility Antigens Class II / immunology; Humans; Major Histocompatibility Complex; Peptides / chemistry; Peptides / immunology; Protein Multimerization
TL;DR:
PMHC multimer usage in defining the role T-cell subsets play in T1D etiology and the therapeutic potential of pMHC for antigen-specific identification and modulation of diabetogenic T cells are provided.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
Sources: ORCID, Crossref, NC State University Libraries
Added: September 9, 2019
2012 review
Making the most of major histocompatibility complex molecule multimers: Applications in type 1 diabetes
[Review of ]. Clinical & Developmental Immunology.
Source: NC State University Libraries
Added: August 6, 2018
2012 journal article
TAK1 (MAP3K7) Signaling Regulates Hematopoietic Stem Cells through TNF-Dependent and -Independent Mechanisms
PLoS ONE, 7(11), e51073.
Contributors: G. Takaesu *, M. Inagaki n, K. Takubo *, Y. Mishina *, n , G. Dean n, A. Yoshimura *, K. Matsumoto *, T. Suda *, J. Ninomiya-Tsuji n
Ed(s): M. Tjwa
MeSH headings : Adaptor Proteins, Signal Transducing / metabolism; Animals; Antigens, Surface / metabolism; Bone Marrow Cells / enzymology; Cell Death; Cell Proliferation; Chimerism; Hematopoietic Stem Cells / cytology; Hematopoietic Stem Cells / enzymology; Humans; MAP Kinase Kinase Kinases / deficiency; MAP Kinase Kinase Kinases / metabolism; MAP Kinase Signaling System; Mice; Mice, Inbred C57BL; Receptors, Tumor Necrosis Factor, Type I / deficiency; Receptors, Tumor Necrosis Factor, Type I / metabolism; Time Factors; Tumor Necrosis Factor-alpha / metabolism
TL;DR:
The results indicate that TAB1- or TAB2-dependent activation of TAK1 is required for maintenance of the hematopoietic system through two mechanisms: one is prevention of TNF-dependent cell death and the other is T NF-independent maintenance of long-term HSC.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
Sources: Crossref, NC State University Libraries, Web Of Science, ORCID
Added: August 6, 2018
2012 journal article
The use of peptide-major-histocompatibility-complex multimers in type 1 diabetes mellitus.
Journal of Diabetes Science and Technology.
MeSH headings : Animals; Autoimmunity; Diabetes Mellitus, Type 1 / immunology; Diabetes Mellitus, Type 1 / therapy; Histocompatibility Antigens / immunology; Histocompatibility Antigens / therapeutic use; Humans; Immunotherapy / methods; Major Histocompatibility Complex / immunology; Molecular Imaging / methods; Peptides / immunology; Peptides / therapeutic use; Protein Multimerization; Signal Transduction; T-Lymphocytes / immunology
TL;DR:
An overview of the development and use of pMHC multimers is provided, particularly in T1DM, and the therapeutic promise these reagents have as an antigen-specific means of ameliorating deleterious T-cell responses in this autoimmune disease is described.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(OpenAlex)
Source: ORCID
Added: September 9, 2019
2011 journal article
Safety and efficacy of a xenogeneic DNA vaccine encoding for human tyrosinase as adjunctive treatment for oral malignant melanoma in dogs following surgical excision of the primary tumor
American Journal of Veterinary Research, 72(12), 1631–1638.
MeSH headings : Administration, Cutaneous; Animals; Cancer Vaccines / immunology; Cancer Vaccines / therapeutic use; DNA, Complementary / genetics; DNA, Complementary / therapeutic use; Dog Diseases / drug therapy; Dog Diseases / immunology; Dogs; Female; Follow-Up Studies; Humans; Kaplan-Meier Estimate; Male; Melanoma / drug therapy; Melanoma / immunology; Melanoma / veterinary; Monophenol Monooxygenase / genetics; Monophenol Monooxygenase / therapeutic use; Mouth Neoplasms / drug therapy; Mouth Neoplasms / immunology; Mouth Neoplasms / veterinary; Neoplasm Staging / veterinary; Oral Surgical Procedures / veterinary; Plasmids / genetics; Plasmids / therapeutic use; Prospective Studies; Treatment Outcome; United States; Vaccines, DNA / immunology; Vaccines, DNA / therapeutic use
TL;DR:
Results support the safety and efficacy of the huTyr DNA vaccine in dogs as adjunctive treatment for oral MM and response to DNA vaccination in dogs with oral MM may be useful in development of plasmid DNA vaccination protocols for human patients with similar disease.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
Sources: ORCID, Web Of Science, NC State University Libraries
Added: September 9, 2019
2010 journal article
Evaluation of an in vitro telomeric repeat amplification protocol assay to detect telomerase activity in canine urine
American Journal of Veterinary Research, 71(12), 1468–1474.
MeSH headings : Animals; Carcinoma, Transitional Cell / enzymology; Carcinoma, Transitional Cell / urine; Carcinoma, Transitional Cell / veterinary; Cell Line, Tumor; Dog Diseases / enzymology; Dog Diseases / urine; Dogs / urine; Electrophoresis, Polyacrylamide Gel; Enzyme Stability; Fibroblasts / enzymology; Lung / enzymology; Polymerase Chain Reaction / methods; Telomerase / analysis; Telomerase / urine; Telomere / genetics
TL;DR:
The TRAP-based assay detected telomerase activity in the canine TCC cell line and revealed that the telomersase ribonucleoprotein complex was inherently unstable at various storage durations and conditions.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Crossref, ORCID, NC State University Libraries
Added: July 20, 2019
2010 article
Pathology in Practice
Palgrave, C. J., Hunter, S. A., Clarke, D. M., & Hess, P. R. (2010, October 15). JAVMA-JOURNAL OF THE AMERICAN VETERINARY MEDICAL ASSOCIATION, Vol. 237, pp. 911–913.
MeSH headings : Animals; Dog Diseases / diagnosis; Dog Diseases / pathology; Dogs; Female; Multiple Myeloma / diagnosis; Multiple Myeloma / pathology; Multiple Myeloma / veterinary
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018
2010 journal article
Toxin-Coupled MHC Class I Tetramers Can Specifically Ablate Autoreactive CD8+ T Cells and Delay Diabetes in Nonobese Diabetic Mice
The Journal of Immunology, 184(8), 4196–4204.
MeSH headings : Animals; Autoantigens / immunology; Autoantigens / metabolism; CD8-Positive T-Lymphocytes / immunology; CD8-Positive T-Lymphocytes / metabolism; CD8-Positive T-Lymphocytes / pathology; Cell Death / immunology; Cell Movement / immunology; Diabetes Mellitus, Type 1 / immunology; Diabetes Mellitus, Type 1 / pathology; Diabetes Mellitus, Type 1 / prevention & control; Disease Progression; Epitopes, T-Lymphocyte / immunology; Female; Glucose-6-Phosphatase / administration & dosage; Glucose-6-Phosphatase / biosynthesis; Glucose-6-Phosphatase / immunology; H-2 Antigens / administration & dosage; H-2 Antigens / toxicity; Histocompatibility Antigen H-2D; Immunotoxins / administration & dosage; Immunotoxins / toxicity; Islets of Langerhans / immunology; Islets of Langerhans / pathology; Mice; Mice, Inbred NOD; Mice, SCID; Mice, Transgenic; Molecular Mimicry / immunology; Proteins / administration & dosage; Proteins / immunology; Receptors, Antigen, T-Cell, alpha-beta / biosynthesis; Receptors, Antigen, T-Cell, alpha-beta / genetics; Ribosome Inactivating Proteins, Type 1 / administration & dosage; Ribosome Inactivating Proteins, Type 1 / toxicity; Saporins; beta 2-Microglobulin / administration & dosage; beta 2-Microglobulin / toxicity
TL;DR:
It is shown that saporin-coupled tetramers can delete islet-specific glucose-6-phosphatase catalytic subunit-related protein (IGRP)-reactive T cells in vitro and in vivo, and deletion at 8 wk of age of IGRP+ CD8+ T cells, but not dystophia myotonica kinase- or insulin B-reactive cells, significantly delays diabetes in NOD mice.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
Sources: Crossref, NC State University Libraries
Added: September 11, 2019
2009 journal article
Islet lymphocyte subsets in male and female NOD mice are qualitatively similar but quantitatively distinct
AUTOIMMUNITY, 42(8), 678–691.
author keywords: Autoimmunity; FoxP3; IGRP; IL-4; naive T-cell
MeSH headings : Age Factors; Animals; B-Lymphocytes / cytology; CD4-CD8 Ratio; CD4-Positive T-Lymphocytes / cytology; CD4-Positive T-Lymphocytes / immunology; CD4-Positive T-Lymphocytes / metabolism; CD8-Positive T-Lymphocytes / cytology; CD8-Positive T-Lymphocytes / immunology; Cell Count; Diabetes Mellitus, Type 1 / immunology; Female; Forkhead Transcription Factors / metabolism; Glucose-6-Phosphatase / immunology; Interleukin-4 / metabolism; Islets of Langerhans / cytology; Islets of Langerhans / immunology; Lymph Nodes / cytology; Lymph Nodes / immunology; Lymphocyte Subsets / cytology; Lymphocyte Subsets / immunology; Male; Mice; Mice, Inbred NOD; Pancreas / cytology; Pancreas / immunology; Pancreatitis / immunology; Proteins / immunology; Sex Characteristics; Spleen / cytology; Spleen / immunology; T-Lymphocyte Subsets / cytology; T-Lymphocyte Subsets / immunology; T-Lymphocyte Subsets / metabolism; T-Lymphocytes, Regulatory / cytology; T-Lymphocytes, Regulatory / immunology; T-Lymphocytes, Regulatory / metabolism; Th2 Cells / cytology; Th2 Cells / immunology; Th2 Cells / metabolism
TL;DR:
The underlying immunological processes in both male and female NOD mice are similar while the rates differ and the presence of naïve T cell in the islets may contribute to epitope spreading.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018
2006 journal article
Selective deletion of antigen-specific CD8(+) T cells by MHC class I tetramers, coupled to the type I ribosome-inactivating protein saporin
BLOOD, 109(8), 3300–3307.
MeSH headings : Animals; Autoimmune Diseases / drug therapy; Autoimmune Diseases / immunology; Autoimmune Diseases / pathology; CD8-Positive T-Lymphocytes / immunology; CD8-Positive T-Lymphocytes / pathology; Cell Death / drug effects; Clonal Deletion / drug effects; Cytotoxins / immunology; Cytotoxins / pharmacology; Histocompatibility Antigens Class I / immunology; Histocompatibility Antigens Class I / pharmacology; Mice; Mice, Transgenic; N-Glycosyl Hydrolases / pharmacology; Plant Proteins / pharmacology; Ribosome Inactivating Proteins, Type 1; Saporins; Time Factors; Transplantation, Homologous
TL;DR:
This work demonstrates the therapeutic potential of cytotoxic tetramers to selectively eradicate pathogenic clonotypes while leaving overall T-cell immunity intact.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018
2005 journal article
Experimental Ehrlichia canis infection in the dog does not cause immunosuppression
VETERINARY IMMUNOLOGY AND IMMUNOPATHOLOGY, 109(1-2), 117–125.
author keywords: Ehrlichia canis; dog; immunoregulation; immunophenotype analysis; lymphocyte proliferation; LAK; CD8(+) T cell
MeSH headings : Animals; Antibody Formation / immunology; CD4-Positive T-Lymphocytes / immunology; CD4-Positive T-Lymphocytes / microbiology; Dog Diseases / immunology; Dog Diseases / microbiology; Dogs; Doxycycline / therapeutic use; Ehrlichia canis / genetics; Ehrlichia canis / immunology; Ehrlichiosis / blood; Ehrlichiosis / immunology; Ehrlichiosis / microbiology; Ehrlichiosis / veterinary; Female; Flow Cytometry / veterinary; Immunity, Cellular / immunology; Immunodiffusion / veterinary; Immunoglobulins / blood; Immunophenotyping / veterinary; Killer Cells, Lymphokine-Activated / immunology; Random Allocation; Specific Pathogen-Free Organisms
TL;DR:
It is suggested that immune responses are not grossly impaired in young dogs during the first several months following experimental E. canis infection.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018
2005 journal article
Thermal dose is related to duration of local control in canine sarcomas treated with thermoradiotherapy
Clinical Cancer Research, 11(14), 5206–5214.
Source: NC State University Libraries
Added: August 6, 2018
2005 journal article
Vaccination with mRNAs encoding tumor-associated antigens and granulocyte-macrophage colony-stimulating factor efficiently primes CTL responses, but is insufficient to overcome tolerance to a model tumor/self antigen
CANCER IMMUNOLOGY IMMUNOTHERAPY, 55(6), 672–683.
author keywords: CTL; mRNA vaccine; GM-CSF; SV40 large T antigen; tolerance
MeSH headings : Animals; Antigens, Neoplasm / immunology; Autoantigens / immunology; Cancer Vaccines / immunology; Disease Models, Animal; Granulocyte-Macrophage Colony-Stimulating Factor / immunology; Immune Tolerance / immunology; Liposomes; Male; Mice; Mice, Inbred C57BL; Mice, Transgenic; Polymerase Chain Reaction; Prostatic Neoplasms / drug therapy; Prostatic Neoplasms / immunology; RNA, Messenger / administration & dosage; T-Lymphocytes, Cytotoxic / immunology; Transfection
TL;DR:
The data from this study suggest that vaccination with TAA mRNA is a simple and effective means of priming antitumor CTL, and that immunogenicity of the vaccine can be augmented by co-delivery of GM-CSF mRNA.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018
2000 chapter
Diagnostic approach to hepatobiliary disease
In Kirk's current meterinary therapy XIII, small animal practice (Vol. 13, pp. 659–664). Philadelphia: WB Saunders Co.
Source: NC State University Libraries
Added: August 6, 2018
1999 journal article
What is your diagnosis? Nodular lung disease
Journal of the American Veterinary Medical Association, 214(2), 193–194.
Source: NC State University Libraries
Added: August 6, 2018
1997 journal article
Steroid-responsive, cervical, pyogranulomatous pachymeningitis in a dog
JOURNAL OF THE AMERICAN ANIMAL HOSPITAL ASSOCIATION, 33(5), 461–468.
MeSH headings : Animals; Dog Diseases / diagnosis; Dog Diseases / drug therapy; Dog Diseases / pathology; Dogs; Dura Mater / pathology; Female; Immunosuppressive Agents / therapeutic use; Meningitis / diagnosis; Meningitis / drug therapy; Meningitis / veterinary; Prednisone / therapeutic use; Radiography; Spinal Cord Compression / etiology; Spinal Cord Compression / veterinary; Spine / diagnostic imaging; Spine / pathology
TL;DR:
This case shares features with hypertrophic spinal pachymeningitis of humans, an uncommon, frequently idiopathic, chronic inflammatory disorder causing dural hypertrophy, radiculopathy, and spinal cord compression.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018
1995 journal article
MANAGEMENT OF PORTAL-HYPERTENSION AND ITS CONSEQUENCES
VETERINARY CLINICS OF NORTH AMERICA-SMALL ANIMAL PRACTICE, 25(2), 461–483.
TL;DR:
Pathophysiology of altered portal vascular dynamics, diagnostic approach for animals suspected of having an intra-abdominal source of portal hypertension and treatment options are discussed.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018
1988 journal article
Effects of neonatal transection upon substance P- and leucine enkephalin-like immunoreactivities in trigeminal subnucleus caudalis of the rat
Journal of Neuroscience, 8(7), 2234–2247.
MeSH headings : Aging / metabolism; Animals; Animals, Newborn; Brain Stem / metabolism; Denervation; Enkephalin, Leucine / metabolism; Immunohistochemistry; Nervous System Physiological Phenomena; Orbit / innervation; Rats; Rats, Inbred Strains; Substance P / metabolism; Tissue Distribution; Trigeminal Caudal Nucleus / metabolism; Trigeminal Nucleus, Spinal / metabolism
TL;DR:
The distributions of substance P-like immunoreactivity in subnucleus caudalis of normal adult rats were compared with those observed in the adult rats that sustained transection of the infraorbital (IO) nerve either on the day of birth or in adulthood.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(OpenAlex)
Sources: NC State University Libraries, NC State University Libraries
Added: August 6, 2018
1988 journal article
The projection from the superficial to the deep layers of the superior colliculus: an intracellular horseradish peroxidase injection study in the hamster
Journal of Neuroscience, 8(4), 1384–1399.
TL;DR:
Results indicate that there is an extensive anatomical substrate by which sensory information may be communicated from superficial to deep layer SC neurons, and that the dendrites of deep layer cells may extend through the SO and into the SGS.
(via Semantic Scholar)
Sources: NC State University Libraries, NC State University Libraries
Added: August 6, 2018
1987 chapter
Development and lesion induced reorganization of the peripheral projections of the trigeminal ganglion in rat
In L. M. Pubols & B. J. Sessle (Eds.), Effects of injury on trigeminal and spinal somatosensory systems (pp. 49–60). New York: Alan R. Liss, Inc.
Ed(s): . L. M. Pubols & B. Sessle
Source: NC State University Libraries
Added: August 6, 2018
1987 journal article
MORPHOLOGICAL-CHARACTERISTICS OF LOW-THRESHOLD PRIMARY AFFERENTS IN THE TRIGEMINAL SUBNUCLEI INTERPOLARIS AND CAUDALIS (THE MEDULLARY DORSAL HORN) OF THE GOLDEN-HAMSTER
JOURNAL OF COMPARATIVE NEUROLOGY, 264(4), 527–546.
MeSH headings : Animals; Cricetinae / anatomy & histology; Cricetinae / physiology; Differential Threshold; Electrophysiology; Mesocricetus; Nerve Fibers / physiology; Neurons, Afferent / classification; Neurons, Afferent / physiology; Neurons, Afferent / ultrastructure; Physical Stimulation; Skin Physiological Phenomena; Spinal Cord / cytology; Spinal Cord / physiology; Spinal Cord / ultrastructure; Trigeminal Nuclei / cytology; Trigeminal Nuclei / physiology; Trigeminal Nuclei / ultrastructure; Vibrissae / physiology
TL;DR:
Intra‐axonal recording and horseradish peroxidase injection techniques were employed to define the response characteristics of low‐threshold, rapidly conducting trigeminal primary afferents and the morphological features of their axon arbors in subnucleus interpolaris and subn nucleus caudalis.
(via Semantic Scholar)
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018
1987 journal article
PREVENTING REGENERATION OF INFRAORBITAL AXONS DOES NOT ALTER THE GANGLIONIC OR TRANSGANGLIONIC CONSEQUENCES OF NEONATAL TRANSECTION OF THIS TRIGEMINAL BRANCH
DEVELOPMENTAL BRAIN RESEARCH, 36(1), 75–88.
MeSH headings : Animals; Animals, Newborn; Axons / physiology; Cell Survival; Nerve Regeneration; Rats; Trigeminal Ganglion / cytology; Trigeminal Ganglion / physiology; Trigeminal Nerve / cytology; Trigeminal Nerve / physiology; Trigeminal Nerve Injuries
TL;DR:
Counts of labelled ganglion cells and examination of the brainstem labelling produced by application of HRP and WGA-HRP to the IO nerve proximal to the point of transection(s) at 6 weeks of age demonstrated no differential effects of preventing regeneration of the cut nerve.
(via Semantic Scholar)
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018
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