Pavak K. Shah

Works (9)

Updated: July 5th, 2023 15:55

2014 journal article

Dynamics and evolution of beta-catenin-dependent Wnt signaling revealed through massively parallel clonogenic screening

INTEGRATIVE BIOLOGY, 6(7), 673–684.

By: P. Shah n, M. Walker *, C. Sims *, M. Major * & N. Allbritton n

MeSH headings : Cell Line, Tumor; Clone Cells; Humans; Image Processing, Computer-Assisted; Kinetics; Luminescent Proteins / chemistry; Luminescent Proteins / metabolism; Microscopy, Fluorescence / methods; Wnt Proteins / metabolism; Wnt Signaling Pathway; beta Catenin / metabolism
TL;DR: A generational-dependent trend in Wnt signaling in A375 cells is revealed that provides insight into the pathway's mechanisms of positive feedback and self-inhibition, which is seen as a challenge to be overcome in the development of novel cell lines and reporter-based assays. (via Semantic Scholar)
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Source: Web Of Science
Added: August 6, 2018

2014 journal article

Small Sample Sorting of Primary Adherent Cells by Automated Micropallet Imaging and Release

CYTOMETRY PART A, 85A(7), 642–649.

By: P. Shah n, S. Herrera-Loeza*, C. Sims *, J. Yeh * & N. Allbritton n

author keywords: image cytometry; xenografts; cell sorting; micropallet arrays
MeSH headings : Animals; Antigens, Neoplasm / analysis; Cell Adhesion Molecules / analysis; Colorectal Neoplasms / pathology; Electronic Data Processing; Epithelial Cell Adhesion Molecule; Flow Cytometry / methods; Heterografts / cytology; Humans; Image Processing, Computer-Assisted; Mice; Mice, Nude; Pancreatic Neoplasms / pathology; Staining and Labeling; Tumor Cells, Cultured
TL;DR: A platform for imaging cytometry integrated with micropallet array technology is developed to perform automated cell sorting on very small samples obtained from PDX models of pancreatic and colorectal cancer using antibody staining of EpCAM (CD326) as a selection criteria, demonstrating the ability to automate and efficiently separate samples with very low number of cells. (via Semantic Scholar)
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Source: Web Of Science
Added: August 6, 2018

2013 journal article

Capture and 3D culture of colonic crypts and colonoids in a microarray platform

Lab on a Chip, 13(23), 4625–4634.

By: Y. Wang, A. Ahmad, P. Shah, C. Sims, S. Magness & N. Allbritton

Source: NC State University Libraries
Added: August 6, 2018

2013 journal article

Microfluidic Chemical Cytometry of Peptide Degradation in Single Drug-Treated Acute Myeloid Leukemia Cells

ANALYTICAL CHEMISTRY, 85(10), 4991–4997.

By: M. Kovarik *, P. Shah n, P. Armistead * & N. Allbritton n

MeSH headings : Amino Acid Sequence; Antineoplastic Agents / pharmacology; Cell Line, Tumor; Humans; Kinetics; Leukemia, Myeloid, Acute / pathology; Microfluidic Analytical Techniques / methods; Peptides / chemistry; Peptides / metabolism; Proteolysis / drug effects
TL;DR: This work used a robust microfluidic platform to explore the heterogeneity of enzyme activity in single cells treated with a chemotherapeutic drug and found a linear dependence of degradation rate on amount of substrate loaded superimposed upon substantial heterogeneity in peptide processing in response to inhibitor treatment. (via Semantic Scholar)
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Source: Web Of Science
Added: August 6, 2018

2013 journal article

Scalable synthesis of a biocompatible, transparent and superparamagnetic photoresist for microdevice fabrication

Journal of Micromechanics and Microengineering, 23(10).

By: P. Shah, M. Hughes, Y. Wang, C. Sims & N. Allbritton

Source: NC State University Libraries
Added: August 6, 2018

2012 review

Micro Total Analysis Systems: Fundamental Advances and Applications in the Laboratory, Clinic, and Field

[Review of ]. ANALYTICAL CHEMISTRY, 85(2), 451–472.

By: M. Kovarik *, D. Ornoff *, A. Melvin *, N. Dobes*, Y. Wang *, A. Dickinson *, P. Gach*, P. Shah*, N. Allbritton n

MeSH headings : Clinical Laboratory Techniques / instrumentation; Equipment Design; Laboratories; Microtechnology / instrumentation
TL;DR: This review focuses on advances in the area of μTAS or “lab-on-a-chip” systems over the time span of May 2011 through September 2012 with a focus on applications in basic research, clinical medicine and field usage. (via Semantic Scholar)
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Source: Web Of Science
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2012 article

Trapping cells on a stretchable microwell array for single-cell analysis (vol 402, pg 1065, 2012)

Analytical and Bioanalytical Chemistry, Vol. 404, pp. 2519–2519.

By: Y. Wang, P. Shah, C. Phillips, C. Sims & N. Allbritton

Source: NC State University Libraries
Added: August 6, 2018

2011 journal article

Trapping cells on a stretchable microwell array for single-cell analysis

ANALYTICAL AND BIOANALYTICAL CHEMISTRY, 402(3), 1065–1072.

By: Y. Wang *, P. Shah*, C. Phillips*, C. Sims * & N. Allbritton*

author keywords: Bioanalytical methods; Cell systems/single-cell analysis; Biochips/high-throughput screening
MeSH headings : Animals; Calcium / metabolism; Cell Line; Dimethylpolysiloxanes / chemistry; Equipment Design; Ionomycin / metabolism; Single-Cell Analysis / economics; Single-Cell Analysis / instrumentation; Tissue Array Analysis / economics; Tissue Array Analysis / instrumentation
TL;DR: A simple, low-cost microarray platform that can trap cells for dynamic single-cell analysis of mammalian cells and demonstrate the utility by multicolor analysis of trapped cells and monitoring in individual cells real-time calcium flux after exposure to the calcium ionophore ionomycin is reported. (via Semantic Scholar)
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Source: Web Of Science
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2007 journal article

Probing protein adsorption onto mercaptoundecanoic acid stabilized gold nanoparticles and surfaces by quartz crystal microbalance and zeta-potential measurements

LANGMUIR, 23(11), 6053–6062.

By: E. Kaufman n, J. Belyea n, M. Johnson n, Z. Nicholson n, J. Ricks n, P. Shah n, M. Bayless n, T. Pettersson  n ...

MeSH headings : Adsorption; Animals; Biosensing Techniques; Cattle; Coated Materials, Biocompatible / chemistry; Cytochromes c / chemistry; Electrochemistry; Fatty Acids / chemistry; Gold / chemistry; Hydrogen-Ion Concentration; In Vitro Techniques; Metal Nanoparticles / chemistry; Myoglobin / chemistry; Proteins / chemistry; Quartz; Serum Albumin, Bovine / chemistry; Surface Properties
TL;DR: The observation of stable BSA complexes on MUA/AuNPs at the isoelectric point by zeta-potential measurements demonstrates that BSA can sterically stabilize MUA /AuNP. (via Semantic Scholar)
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Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018

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