Paul T Hamilton
Also known as: Paul T. Hamilton
Works (36)
Updated: April 4th, 2024 16:00
2021 journal article
Remodeling hydrogen bond Interactions results in relaxed specificity of Caspase-3
BIOSCIENCE REPORTS, 41(1).
MeSH headings : Amino Acid Sequence; Animals; Aspartic Acid / metabolism; Caspase 3 / chemistry; Caspase 3 / metabolism; Caspase 6 / metabolism; Humans; Hydrogen Bonding; Sequence Homology, Amino Acid; Substrate Specificity; Valine / metabolism; Zebrafish; Zebrafish Proteins / chemistry; Zebrafish Proteins / metabolism
open access via doi.org (publisher)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, NC State University Libraries
Added: April 12, 2021
2020 journal article
Caspases from scleractinian coral show unique regulatory features
JOURNAL OF BIOLOGICAL CHEMISTRY, 295(43), 14578–14591.
author keywords: caspase; cysteine protease; allosteric regulation; substrate specificity; coral apoptosis; coral immunity; functional divergence; substrate selection; CARD-caspase; apoptosis
MeSH headings : Amino Acid Sequence; Animals; Anthozoa / chemistry; Anthozoa / cytology; Anthozoa / enzymology; Anthozoa / metabolism; Apoptosis; Caspases / chemistry; Caspases / metabolism; Coral Reefs; Crystallography, X-Ray; Enzyme Activation; Humans; Models, Molecular; Protein Conformation; Protein Domains; Sequence Alignment; Substrate Specificity
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
14. Life Below Water
(OpenAlex)
Sources: ORCID, Web Of Science, NC State University Libraries
Added: January 14, 2021
2019 journal article
Resurrection of ancestral effector caspases identifies novel networks for evolution of substrate specificity.
The Biochemical Journal.
MeSH headings : Animals; Caspases, Effector / chemistry; Caspases, Effector / genetics; Caspases, Effector / metabolism; Evolution, Molecular; Humans; Mammals / classification; Mammals / genetics; Phylogeny; Protein Conformation; Substrate Specificity
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Source: ORCID
Added: November 6, 2019
2017 journal article
An Internship May Not Be Enough: Enhancing Bioscience Industry Job Readiness through Practicum Experiences.
Journal of Microbiology & Biology Education, 18(1).
UN Sustainable Development Goal Categories
4. Quality Education
(Web of Science)
Source: ORCID
Added: January 31, 2019
2016 journal article
Phage display and structural studies reveal plasticity in substrate specificity of caspase-3a from zebrafish
Protein Science, 25(11), 2076–2088.
Contributors: M. Tucker n, S. MacKenzie n, J. Maciag n, H. Dirscherl Ackerman, P. Swartz n, J. Yoder n , n , A. Clay Clark *
author keywords: phage display substrate library; substrate recognition; Danio rerio; apoptosis
MeSH headings : Allosteric Regulation; Animals; Caspase 3 / chemistry; Crystallography, X-Ray; Molecular Dynamics Simulation; Peptide Library; Substrate Specificity; Zebrafish
TL;DR:
The structure of zebrafish Casp3a is determined to 2.28Å resolution by X‐ray crystallography, and the results suggest that a limited number of amino acid substitutions near the active site result in plasticity of the S4 sub‐site by increasing flexibility of one active site loop and by affecting hydrogen‐bonding with substrate.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: ORCID, Crossref, NC State University Libraries
Added: January 31, 2019
2015 article
High-Throughput and High-Content Screening Using Peptides
Carlson, R., Hyde-DeRuyscher, R., & Hamilton, P. (2015, February). Phage Display In Biotechnology and Drug Discovery, Second Edition, pp. 249–274.
Source: ORCID
Added: January 31, 2019
2015 book
High-throughput and high-content screening using peptides
In Phage Display in Biotechnology and Drug Discovery, Second Edition (pp. 249–274).
Source: ORCID
Added: February 1, 2019
2014 journal article
Characterization of a thermophilic bacteriophage of Geobacillus kaustophilus
ARCHIVES OF VIROLOGY, 159(10), 2771–2775.
MeSH headings : Bacillus subtilis / virology; Bacteriophages / genetics; Bacteriophages / isolation & purification; Base Composition; Base Sequence; DNA, Viral / genetics; Genome, Viral / genetics; Geobacillus / virology; Hot Temperature; Molecular Sequence Data; Open Reading Frames / genetics; Sequence Analysis, DNA; Soil Microbiology; Viral Proteins / genetics
TL;DR:
The overall genomic arrangement of GBK2 is similar to that of SPP1, with the majority ofGBK2SPP1-like genes coding for proteins involved in DNA replication and metabolism.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
15. Life on Land
(Web of Science)
Sources: Web Of Science, ORCID, NC State University Libraries
Added: August 6, 2018
2013 journal article
Cooperative Learning through Team-Based Projects in the Biotechnology Industry †
Journal of Microbiology & Biology Education, 14(2), 221–229.
TL;DR:
Using peer-evaluations, this model of team-based, industry-sponsored projects could be implemented in other college and university courses/programs to promote professional skills and expose students to an industry setting.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
4. Quality Education
(Web of Science)
Source: ORCID
Added: January 31, 2019
2013 journal article
Improved Bone Morphogenetic Protein-2 Retention in an Injectable Collagen Matrix Using Bifunctional Peptides
PLOS ONE, 8(8).
Contributors: n , M. Jansen*, S. Ganesan*, R. Benson*, R. Hyde-DeRuyscher*, W. Beyer, J. Gile, S. Nair*, J. Hodges*, H. Grøn*
Ed(s): F. Gelain
MeSH headings : Amino Acid Sequence; Animals; Biocompatible Materials / administration & dosage; Biocompatible Materials / chemistry; Biocompatible Materials / metabolism; Bone Morphogenetic Protein 2 / administration & dosage; Bone Morphogenetic Protein 2 / metabolism; Bone Morphogenetic Protein 2 / pharmacology; Collagen / administration & dosage; Collagen / chemistry; Collagen / metabolism; Injections; Male; Molecular Sequence Data; Osteogenesis / drug effects; Peptide Library; Peptides / administration & dosage; Peptides / chemistry; Peptides / metabolism; Protein Binding; Rats; Rats, Sprague-Dawley
TL;DR:
It is suggested that bifunctional peptides that can simultaneously bind to a growth factor and an implantable biomaterial can be used to control the delivery and release of growth factors at the site of implantation.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, ORCID, NC State University Libraries
Added: August 6, 2018
2012 journal article
Preparing Science-Trained Professionals for the Biotechnology Industry: A Ten-Year Perspective on a Professional Science Master’s Program
Journal of Microbiology & Biology Education : JMBE, 13(1), 39–44.
TL;DR:
An overview of the PSM program in Microbial Biotechnology is provided, and some of the lessons that have been learned are shared.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: ORCID, Web Of Science, NC State University Libraries
Added: January 31, 2019
2009 journal article
Directed Assembly of PEGylated-Peptide Coatings for Infection-Resistant Titanium Metal
J. Am. Chem. Soc., 131(31), 10992–10997.
Contributors: X. Khoo*, * , . G.A. O'Toole, B. Snyder *, D. Kenan * & M. Grinstaff *
MeSH headings : Amino Acid Substitution; Coated Materials, Biocompatible / chemistry; Combinatorial Chemistry Techniques; Fibronectins / drug effects; Infection Control / methods; Peptide Library; Peptides / chemistry; Polyethylene Glycols / chemistry; Prostheses and Implants / microbiology; Prostheses and Implants / standards; Staphylococcus aureus / drug effects; Titanium / chemistry
TL;DR:
These PEGylated-peptide coatings show promise in terms of resolving two major hurdles common to implanted metals: (i) nonspecific protein adsorption and (ii) bacterial colonization.
(via Semantic Scholar)
Source: ORCID
Added: January 31, 2019
2008 conference paper
A peptide coating for the endothelialization of intravascular devices
8th World Biomaterials Congress 2008, 1, 200. http://www.scopus.com/inward/record.url?eid=2-s2.0-84869012621&partnerID=MN8TOARS
Source: ORCID
Added: February 1, 2019
2008 conference paper
Growth factor coated sutures for improved tendon repair
8th World Biomaterials Congress 2008, 1, 179. http://www.scopus.com/inward/record.url?eid=2-s2.0-84869010182&partnerID=MN8TOARS
Source: ORCID
Added: February 1, 2019
2007 journal article
Endothelialization of Titanium Surfaces
Adv. Mater., 19(18), 2492–2498.
Contributors: S. Meyers *, * , E. Walsh*, D. Kenan * & M. Grinstaff *
TL;DR:
There is new concern regarding the use of drug-eluting stents owing to an increased thrombolytic potential of two to three fold compared to bare metal stents.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(OpenAlex)
Source: ORCID
Added: January 31, 2019
2005 article
High Throughput and High Content Screening Using Peptides
Hamilton, P., Carlson, R., & Hyde-Deruyscher, R. (2005, July). Phage Display In Biotechnology and Drug Discovery, pp. 347–384.
Source: ORCID
Added: January 31, 2019
2003 journal article
Identification and characterization of peptide probes directed against PKCα conformations
The Journal of Peptide Research, 61(5), 263–273.
author keywords: conformational probes; peptide phage display; protein kinase C; surrogate ligands
MeSH headings : Amino Acid Sequence; Binding Sites; Isoenzymes / chemistry; Isoenzymes / metabolism; Molecular Probes / chemistry; Molecular Probes / metabolism; Peptide Library; Peptides / chemistry; Peptides / metabolism; Protein Binding; Protein Kinase C / chemistry; Protein Kinase C / metabolism; Protein Kinase C-alpha
TL;DR:
This work has identified separate classes of peptides that bind to protein kinase C alpha (PKCalpha) only under activation conditions, and peptide binding was specific to PKCalpha and not to any of the other closely related PKC isoforms.
(via Semantic Scholar)
Source: ORCID
Added: January 31, 2019
2003 journal article
Intracellular Expression of Peptide Fusions for Demonstration of Protein Essentiality in Bacteria
Antimicrobial Agents and Chemotherapy, 47(9), 2875–2881.
MeSH headings : Bacterial Proteins / genetics; Bacterial Proteins / physiology; Blotting, Western; Culture Media; DNA Replication; DNA, Bacterial / genetics; DNA, Bacterial / metabolism; DNA, Superhelical / biosynthesis; DNA, Superhelical / genetics; Escherichia coli / growth & development; Escherichia coli / metabolism; Genetic Vectors; Peptide Library; Peptides / metabolism; Plasmids / genetics; Protein Biosynthesis; Reverse Transcriptase Polymerase Chain Reaction; Transcription, Genetic / genetics
TL;DR:
In growth-inhibited cells, inhibition could be relieved by concurrent overexpression of the relevant target protein but not by coexpression of an irrelevant protein, indicating that growth inhibition was due to a specific interaction of the expressed peptide with its target.
(via Semantic Scholar)
Source: ORCID
Added: January 31, 2019
2003 article
Surrogate Ligand-Based Assay Systems for Discovery of Antibacterial Agents for Genomic Targets
Hamilton, P., & Christensen, D. (2003, May). Microbial Genomics and Drug Discovery, pp. 173–185.
Source: ORCID
Added: January 31, 2019
2001 journal article
Identification of Enzyme Inhibitors from Phage-Displayed Combinatorial Peptide Libraries
CCHTS, 4(7), 535–543.
Contributors: B. Kay * & *
MeSH headings : Amino Acid Sequence; Bacteriophages / drug effects; Bacteriophages / enzymology; Combinatorial Chemistry Techniques; Enzyme Inhibitors / pharmacology; Escherichia coli / enzymology; Ligands; Molecular Sequence Data; Peptide Library; Tetrahydrofolate Dehydrogenase / metabolism
TL;DR:
Data is presented on peptide ligands the authors have identified for E. coli dihydrofolate reductase (DHFR) which bind at, or near, the same site as the known inhibitors methotrexate or trimethoprim.
(via Semantic Scholar)
Source: ORCID
Added: January 31, 2019
2001 journal article
Phage display for target-based antibacterial drug discovery
Drug Discovery Today, 6(14), 721–727.
TL;DR:
Peptides isolated by phage display can be used as 'surrogate ligands' in competition assays for screening of targets of unknown function with small-molecule libraries, including those based on radioactive, luminescence or fluorescence detection.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(OpenAlex)
Source: ORCID
Added: January 31, 2019
2000 journal article
Detection of small-molecule enzyme inhibitors with peptides isolated from phage-displayed combinatorial peptide libraries
Chemistry & Biology, 7(1), 17–25.
Contributors: R. Hyde-Deruyscher*, L. Paige, D. Christensen, N. Hyde-Deruyscher, A. Lim*, Z. Fredericks*, J. Kranz *, P. Gallant*
author keywords: enzyme inhibitors; fluorescence polarization; high-throughput screening; peptide ligand; phage display; time-resolved fluorescence
MeSH headings : Alcohol Dehydrogenase / antagonists & inhibitors; Amino Acid Sequence; Amino Acyl-tRNA Synthetases / antagonists & inhibitors; Bacteriophages / metabolism; Biotin / chemistry; Carboxypeptidase B; Carboxypeptidases / antagonists & inhibitors; Chromatography, Affinity; Enzyme Inhibitors / analysis; Enzyme Inhibitors / isolation & purification; Enzyme Inhibitors / pharmacology; Enzyme-Linked Immunosorbent Assay; Haemophilus influenzae / enzymology; Hexokinase / antagonists & inhibitors; Kinetics; Ligands; Molecular Sequence Data; Peptide Library; Phosphorylases / antagonists & inhibitors; Tyrosine-tRNA Ligase / antagonists & inhibitors; beta-Glucosidase / antagonists & inhibitors
TL;DR:
Peptidic surrogate ligands identified using phage display are preferentially targeted to a limited number of sites that inhibit enzyme function and can be utilized in a binding assay as a rapid and sensitive method to detect small-molecule inhibitors of target protein function.
(via Semantic Scholar)
Source: ORCID
Added: January 31, 2019
1999 journal article
Dissection of the LXXLL Nuclear Receptor-Coactivator Interaction Motif Using Combinatorial Peptide Libraries: Discovery of Peptide Antagonists of Estrogen Receptors α and β
Mol. Cell. Biol., 19(12), 8226–8239.
Contributors: C. Chang *, J. Norris, H. Grøn*, L. Paige*, * , D. Kenan *, D. Fowlkes*, D. McDonnell
MeSH headings : Amino Acid Sequence; Binding Sites; Estrogen Receptor alpha; Estrogen Receptor beta; HeLa Cells; Humans; Ligands; Molecular Sequence Data; Peptide Library; Peptides / metabolism; Receptors, Cytoplasmic and Nuclear / metabolism; Receptors, Estrogen / genetics; Receptors, Estrogen / metabolism; Recombinant Fusion Proteins / genetics; Recombinant Fusion Proteins / metabolism; Transcription, Genetic; Tumor Cells, Cultured
TL;DR:
It is shown that not all LXXLL motifs are functionally equivalent, a finding which suggests that it may be possible to target receptor-LXXLL interactions to develop receptor-specific antagonists.
(via Semantic Scholar)
Source: ORCID
Added: January 31, 2019
1999 journal article
Estrogen receptor (ER) modulators each induce distinct conformational changes in ER and ER
Proceedings of the National Academy of Sciences, 96(7), 3999–4004.
Contributors: L. Paige*, D. Christensen*, H. Grøn*, J. Norris *, E. Gottlin *, K. Padilla*, C. Chang *, L. Ballas*
MeSH headings : Amino Acid Sequence; Binding Sites; Estradiol / pharmacology; Estradiol Congeners / pharmacology; Estriol / pharmacology; Estrogen Antagonists / pharmacology; Estrogen Receptor alpha; Estrogen Receptor beta; Estrogens / pharmacology; Humans; Molecular Sequence Data; Protein Conformation / drug effects; Receptors, Estrogen / chemistry; Receptors, Estrogen / drug effects; Sequence Alignment; Sequence Homology, Amino Acid; Tamoxifen / analogs & derivatives; Tamoxifen / pharmacology
TL;DR:
It is shown that ER ligands, known to produce distinct biological effects, induce distinct conformational changes in the receptors, providing a strong correlation between ER conformation and biological activity.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
10. Reduced Inequalities
(OpenAlex)
Source: ORCID
Added: January 31, 2019
1999 journal article
Peptide antagonists of the human estrogen receptor
Science, 285(5428), 744–746.
Contributors: J. Norris *, L. Paige, D. Christensen, C. Chang *, M. Huacani*, D. Fan*, * , D. Fowlkes, D. McDonnell *
MeSH headings : Amino Acid Sequence; Binding Sites; Estradiol / metabolism; Estradiol / pharmacology; Estrogen Antagonists / pharmacology; Estrogen Receptor alpha; Humans; Ligands; Mifepristone / pharmacology; Molecular Sequence Data; Peptide Library; Peptides / metabolism; Peptides / pharmacology; Receptors, Cytoplasmic and Nuclear / metabolism; Receptors, Estrogen / agonists; Receptors, Estrogen / antagonists & inhibitors; Receptors, Estrogen / chemistry; Receptors, Estrogen / metabolism; Recombinant Fusion Proteins / pharmacology; Tamoxifen / metabolism; Tamoxifen / pharmacology; Transcription Factor AP-1 / genetics; Transcription Factor AP-1 / metabolism; Transcription, Genetic / drug effects
TL;DR:
The ability to regulate estrogen receptoralpha transcriptional activity by targeting sites outside of the ligand-binding pocket has implications for the development of estrogen receptor alpha antagonists for the treatment of tamoxifen-refractory breast cancers.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(OpenAlex)
Source: ORCID
Added: February 1, 2019
1995 article
Applying Genetic Engineering to the Structural Analysis of Proteins
Physical Methods to Characterize Pharmaceutical Proteins, pp. 329–350.
MeSH headings : Amino Acid Sequence; Base Sequence; Biotechnology; Cloning, Molecular; Coliphages / genetics; DNA, Recombinant / genetics; Escherichia coli / genetics; Gene Expression; Genetic Vectors; Molecular Sequence Data; Mutagenesis; Polymerase Chain Reaction; Protein Engineering / methods; Proteins / chemistry; Proteins / genetics; Recombinant Fusion Proteins / chemistry; Recombinant Fusion Proteins / genetics; Recombinant Fusion Proteins / isolation & purification; Technology, Pharmaceutical
TL;DR:
Genetic engineering offers many techniques that can be applied to the structural analysis of proteins, which aid in the characterization of the protein but also can be applications to the generation of completely new diagnostic and therapeutic agents.
(via Semantic Scholar)
Source: ORCID
Added: January 31, 2019
1995 journal article
Applying genetic engineering to the structural analysis of proteins.
Pharmaceutical Biotechnology, 7, 329–350. http://www.scopus.com/inward/record.url?eid=2-s2.0-0029449448&partnerID=MN8TOARS
Source: ORCID
Added: February 1, 2019
1993 journal article
Expression of a single-chain antibody as a maltose binding protein fusion
Protein Engineering, Design and Selection, 6, 88.
Source: ORCID
Added: February 1, 2019
1989 journal article
A hydrogenase-linked gene in Methanobacterium thermoautotrophicum strain delta H encodes a polyferredoxin.
Proceedings of the National Academy of Sciences, 86(9), 3031–3035.
Contributors: J. Reeve *, G. Beckler*, D. Cram *, * , J. Brown *, J. Krzycki*, A. Kolodziej*, L. Alex*, W. Orme-Johnson*, C. Walsh *
MeSH headings : Amino Acid Sequence; Base Sequence; Biological Evolution; Cloning, Molecular; Codon; Euryarchaeota / enzymology; Euryarchaeota / genetics; Ferredoxins / genetics; Genes, Bacterial; Hydrogenase / genetics; Molecular Sequence Data; Operon; Polymers; Transcription, Genetic
TL;DR:
The genes mvhDGA, which encode the subunit polypeptides of the methyl viologen-reducing hydrogenase in Methanobacterium thermoautotrophicum strain delta H, have been cloned and sequenced.
(via Semantic Scholar)
Source: ORCID
Added: January 31, 2019
1989 journal article
Nucleotide sequence of the major outer membrane protein gene from Chlamydia trachomatis serovar H
Nucl Acids Res, 17(20), 8366–8366.
MeSH headings : Amino Acid Sequence; Bacterial Outer Membrane Proteins / genetics; Base Sequence; Chlamydia trachomatis / genetics; Genes, Bacterial; Molecular Sequence Data
TL;DR:
The gene encoding the major outer membrane protein (MOMP) from Chlamydia trachomatis, serovar H was isolated from a genomic library using the MOMP gene fromserovar L2 as the probe and the nucleotide sequence was determined by the dideoxy chain termination method.
(via Semantic Scholar)
Source: ORCID
Added: January 31, 2019
1989 journal article
Polyferredoxin: A methanogen hydrogenase operon encodes a gene for a 12 × (4Fe4S) protein
Journal of Inorganic Biochemistry, 36(3-4), 221.
Source: ORCID
Added: January 31, 2019
1987 article
Divergence of Methanogens, Conservation of the His I Gene Sequence in all Three Biological Kingdoms and the Status of Methanobacterium Thermoautotrophicum
Microbial Growth on C1 Compounds, pp. 255–260.
TL;DR:
Using gene cloning in Escherichia coli to investigate the basic structure of methanogen genes and to use E. coli to synthesize meethanogen enzymes involved in methanogenesis and nitrogen fixation.
(via Semantic Scholar)
Source: ORCID
Added: January 31, 2019
1986 journal article
Structure of methanogen genes
Systematic and Applied Microbiology, 7(1), 5–12.
Contributors: J. Reeve *, * , G. Beckler*, C. Morris * & C. Clarke*
TL;DR:
An analysis of the structure and presumed regulatory signals in sequenced methanogen genes is presented and it is indicated that a consensus core ribosome binding sequence for methanogens would be 5 'AGGTGA and that many of the ribosom binding sequences are, in fact, longer than the core sequence containing 7 bases with the potential to hybridize to 16SrRNA.
(via Semantic Scholar)
Source: ORCID
Added: January 31, 2019
1985 journal article
Sequence divergence of an archaebacterial gene cloned from a mesophilic and a thermophilic methanogen
J Mol Evol, 22(4), 351–360.
Contributors: * & J. Reeve *
MeSH headings : Amino Acid Sequence; Base Composition; Base Sequence; Biological Evolution; Cloning, Molecular; Escherichia coli / genetics; Euryarchaeota / genetics; Genes; Genes, Bacterial; Genetic Variation; Genotype; Phenotype; Plasmids; Species Specificity
TL;DR:
A 1.6-kb fragment of DNA from the thermophilic, methane-producing, anaerobic archaebacteriumMethanobacterium thermoautotrophicum ΔH has been cloned and sequenced and predicts that complementation in E. coli results from the synthesis of a polypeptide with a molecular weight of 36,249.
(via Semantic Scholar)
Source: ORCID
Added: January 31, 2019
1985 journal article
Structure of genes and an insertion element in the methane producing archaebacterium Methanobrevibacter smithii
Molec. Gen. Genet., 200(1), 47–59.
Contributors: * & J. Reeve *
MeSH headings : Amino Acid Sequence; Archaea / genetics; Bacteria / genetics; Bacterial Proteins / genetics; Base Sequence; Cloning, Molecular; Codon; DNA Restriction Enzymes; DNA Transposable Elements; Escherichia coli / genetics; Genes; Genes, Bacterial; Genotype; Methane / metabolism; Mutation; Nucleic Acid Hybridization; Phenotype
TL;DR:
Sequence analyses, transposon mutagenesis and expression in E. coli minicells indicate that purE and proC complementations result from the synthesis of M. smithii polypeptides, and comparison of data with sequences from halophilic archaebacteria suggests that 5′GAANTTTCA and 5′TTTTAATATAAA may be consensus promoter sequences for archaEBacteria.
(via Semantic Scholar)
Source: ORCID
Added: January 31, 2019
1982 journal article
Beginning genetics with methanogens.
Basic Life Sciences, 19, 233–244. http://www.scopus.com/inward/record.url?eid=2-s2.0-0020009847&partnerID=MN8TOARS
Source: ORCID
Added: February 1, 2019
Employment
Updated: July 5th, 2016 10:20
2009 - present
North Carolina State University Raleigh, NC, US
Associate Professor
Plant and Microbial Biology
Education
Updated: July 5th, 2016 10:27
1980 - 1984
Ohio State University Columbus, OH, US
Ph.D in Microbiology
Microbiology
1976 - 1980
University of Michigan Ann Arbor, MI, US
Bachelor of Science in Microbiology
Funding History
Funding history based on the linked ORCID record. Updated: December 10th, 2019 19:37
grant
September 1, 2019 - August 1, 2022
NSF IGE: Accelerate to Industry (A2i)
National Science Foundation
grant
September 15, 2015 - May 31, 2016
I-Corps: Industrial Enzymes from the Microbiomes of Household Insects
National Science Foundation - Directorate for Engineering
grant
May 15, 2008 - April 30, 2009
Antibiotic-binding Peptides for Biofilm Prevention on Ventriculoperitoneal Shunts
National Institute of Neurological Disorders and Stroke
grant
May 15, 2008 - April 30, 2009
Antibiotic-binding Peptides for Biofilm Prevention on Ventriculoperitoneal Shunts
National Institute of Neurological Disorders and Stroke
grant
April 14, 2008 - August 1, 2009
Localized Growth Factor Therapy for Surgical Hernia Repair
National Institute of General Medical Sciences
grant
April 14, 2008 - August 1, 2009
Localized Growth Factor Therapy for Surgical Hernia Repair
National Institute of General Medical Sciences
grant
September 20, 2007 - August 31, 2010
Interfacial Adapters for Improved Cell Delivery to Tissues
National Heart Lung and Blood Institute
grant
July 2, 2007 - June 30, 2008
Point of Care Attachment of Multiple Antibiotics onto Metal Implants
National Institute of Dental and Craniofacial Research
grant
July 2, 2007 - July 31, 2011
Point of Care Attachment of Antibiotics onto Metal Implants
National Institute of Allergy and Infectious Diseases
grant
July 2, 2007 - June 30, 2008
Point of Care Attachment of Multiple Antibiotics onto Metal Implants
National Institute of Dental and Craniofacial Research
grant
September 30, 2006 - September 29, 2008
Discovery of a Platelet Derived Growth Factor Peptide-based Mimetic
National Institute of Diabetes and Digestive and Kidney Diseases
grant
September 30, 2006 - September 29, 2008
Discovery of a Platelet Derived Growth Factor Peptide-based Mimetic
National Institute of Diabetes and Digestive and Kidney Diseases
grant
September 1, 2006 - August 31, 2007
Injectable BMP-2 Formulation for Fracture Healing
National Institute of Arthritis and Musculoskeletal and Skin Diseases
grant
September 1, 2006 - August 31, 2007
Injectable BMP-2 Formulation for Fracture Healing
National Institute of Arthritis and Musculoskeletal and Skin Diseases
grant
June 28, 2006 - March 31, 2008
Growth Factor Coated Sutures for Improved Tendons Repair
National Institute of Arthritis and Musculoskeletal and Skin Diseases
grant
June 28, 2006 - March 31, 2008
Growth Factor Coated Sutures for Improved Tendons Repair
National Institute of Arthritis and Musculoskeletal and Skin Diseases
grant
July 1, 2005 - June 30, 2007
Discovery of Peptide-based Bone Morphogenic Protein Mimetics
National Institute of Arthritis and Musculoskeletal and Skin Diseases
grant
July 1, 2005 - June 30, 2007
Discovery of Peptide-based Bone Morphogenic Protein Mimetics
National Institute of Arthritis and Musculoskeletal and Skin Diseases
grant
April 1, 2005 - March 31, 2006
Improved Orthopedic Implant Surface Coatings
National Institute of Arthritis and Musculoskeletal and Skin Diseases
grant
April 1, 2005 - March 31, 2006
Improved Orthopedic Implant Surface Coatings
National Institute of Arthritis and Musculoskeletal and Skin Diseases
grant
April 1, 2004 - August 31, 2009
Improved Orthopedic Implant Surface Coatings
National Institute of Arthritis and Musculoskeletal and Skin Diseases
grant
April 1, 2004 - August 31, 2009
Improved Orthopedic Implant Surface Coatings
National Institute of Arthritis and Musculoskeletal and Skin Diseases
grant
September 1, 1999 - February 28, 2001
A NOVEL APPROACH TO THE DISCOVERY OF ANTIBACTERIAL DRUGS
National Institute of Allergy and Infectious Diseases
grant
September 1, 1999 - February 28, 2001
A NOVEL APPROACH TO THE DISCOVERY OF ANTIBACTERIAL DRUGS
National Institute of Allergy and Infectious Diseases
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