Paul T Hamilton
Also known as: Paul T. Hamilton
Works (36)
Updated: July 26th, 2023 21:15
2021 journal article
Remodeling hydrogen bond Interactions results in relaxed specificity of Caspase-3
BIOSCIENCE REPORTS, 41(1).
MeSH headings : Amino Acid Sequence; Animals; Aspartic Acid / metabolism; Caspase 3 / chemistry; Caspase 3 / metabolism; Caspase 6 / metabolism; Humans; Hydrogen Bonding; Sequence Homology, Amino Acid; Substrate Specificity; Valine / metabolism; Zebrafish; Zebrafish Proteins / chemistry; Zebrafish Proteins / metabolism
doi.org (publisher)
Sources: Web Of Science, ORCID
Added: April 12, 2021
2020 journal article
Caspases from scleractinian coral show unique regulatory features
JOURNAL OF BIOLOGICAL CHEMISTRY, 295(43), 14578–14591.
author keywords: caspase; cysteine protease; allosteric regulation; substrate specificity; coral apoptosis; coral immunity; functional divergence; substrate selection; CARD-caspase; apoptosis
MeSH headings : Amino Acid Sequence; Animals; Anthozoa / chemistry; Anthozoa / cytology; Anthozoa / enzymology; Anthozoa / metabolism; Apoptosis; Caspases / chemistry; Caspases / metabolism; Coral Reefs; Crystallography, X-Ray; Enzyme Activation; Humans; Models, Molecular; Protein Conformation; Protein Domains; Sequence Alignment; Substrate Specificity
Sources: ORCID, Web Of Science
Added: January 14, 2021
2019 journal article
Resurrection of ancestral effector caspases identifies novel networks for evolution of substrate specificity.
The Biochemical Journal.
MeSH headings : Animals; Caspases, Effector / chemistry; Caspases, Effector / genetics; Caspases, Effector / metabolism; Evolution, Molecular; Humans; Mammals / classification; Mammals / genetics; Phylogeny; Protein Conformation; Substrate Specificity
Source: ORCID
Added: November 6, 2019
2017 journal article
An Internship May Not Be Enough: Enhancing Bioscience Industry Job Readiness through Practicum Experiences.
Journal of Microbiology & Biology Education, 18(1).
Source: ORCID
Added: January 31, 2019
2016 journal article
Phage display and structural studies reveal plasticity in substrate specificity of caspase-3a from zebrafish
Protein Science, 25(11), 2076–2088.
author keywords: phage display substrate library; substrate recognition; Danio rerio; apoptosis
MeSH headings : Allosteric Regulation; Animals; Caspase 3 / chemistry; Crystallography, X-Ray; Molecular Dynamics Simulation; Peptide Library; Substrate Specificity; Zebrafish
Sources: ORCID, Crossref
Added: January 31, 2019
2015 article
High-Throughput and High-Content Screening Using Peptides
Carlson, R., Hyde-DeRuyscher, R., & Hamilton, P. (2015, February). Phage Display In Biotechnology and Drug Discovery, Second Edition, pp. 249–274.
Source: ORCID
Added: January 31, 2019
2015 book
High-throughput and high-content screening using peptides
In Phage Display in Biotechnology and Drug Discovery, Second Edition (pp. 249–274).
Source: ORCID
Added: February 1, 2019
2014 journal article
Characterization of a thermophilic bacteriophage of Geobacillus kaustophilus
ARCHIVES OF VIROLOGY, 159(10), 2771–2775.
MeSH headings : Bacillus subtilis / virology; Bacteriophages / genetics; Bacteriophages / isolation & purification; Base Composition; Base Sequence; DNA, Viral / genetics; Genome, Viral / genetics; Geobacillus / virology; Hot Temperature; Molecular Sequence Data; Open Reading Frames / genetics; Sequence Analysis, DNA; Soil Microbiology; Viral Proteins / genetics
Sources: Web Of Science, ORCID
Added: August 6, 2018
2013 journal article
Cooperative Learning through Team-Based Projects in the Biotechnology Industry †
Journal of Microbiology & Biology Education, 14(2), 221–229.
Source: ORCID
Added: January 31, 2019
2013 journal article
Improved Bone Morphogenetic Protein-2 Retention in an Injectable Collagen Matrix Using Bifunctional Peptides
PLOS ONE, 8(8).
Ed(s): F. Gelain
MeSH headings : Amino Acid Sequence; Animals; Biocompatible Materials / administration & dosage; Biocompatible Materials / chemistry; Biocompatible Materials / metabolism; Bone Morphogenetic Protein 2 / administration & dosage; Bone Morphogenetic Protein 2 / metabolism; Bone Morphogenetic Protein 2 / pharmacology; Collagen / administration & dosage; Collagen / chemistry; Collagen / metabolism; Injections; Male; Molecular Sequence Data; Osteogenesis / drug effects; Peptide Library; Peptides / administration & dosage; Peptides / chemistry; Peptides / metabolism; Protein Binding; Rats; Rats, Sprague-Dawley
Sources: Web Of Science, ORCID
Added: August 6, 2018
2012 journal article
Preparing Science-Trained Professionals for the Biotechnology Industry: A Ten-Year Perspective on a Professional Science Master’s Program
Journal of Microbiology & Biology Education : JMBE, 13(1), 39–44.
Sources: ORCID, Web Of Science
Added: January 31, 2019
2009 journal article
Directed Assembly of PEGylated-Peptide Coatings for Infection-Resistant Titanium Metal
J. Am. Chem. Soc., 131(31), 10992–10997.
MeSH headings : Amino Acid Substitution; Coated Materials, Biocompatible / chemistry; Combinatorial Chemistry Techniques; Fibronectins / drug effects; Infection Control / methods; Peptide Library; Peptides / chemistry; Polyethylene Glycols / chemistry; Prostheses and Implants / microbiology; Prostheses and Implants / standards; Staphylococcus aureus / drug effects; Titanium / chemistry
Source: ORCID
Added: January 31, 2019
2008 conference paper
A peptide coating for the endothelialization of intravascular devices
8th World Biomaterials Congress 2008, 1, 200. http://www.scopus.com/inward/record.url?eid=2-s2.0-84869012621&partnerID=MN8TOARS
Source: ORCID
Added: February 1, 2019
2008 conference paper
Growth factor coated sutures for improved tendon repair
8th World Biomaterials Congress 2008, 1, 179. http://www.scopus.com/inward/record.url?eid=2-s2.0-84869010182&partnerID=MN8TOARS
Source: ORCID
Added: February 1, 2019
2007 journal article
Endothelialization of Titanium Surfaces
Adv. Mater., 19(18), 2492–2498.
Source: ORCID
Added: January 31, 2019
2005 article
High Throughput and High Content Screening Using Peptides
Hamilton, P., Carlson, R., & Hyde-Deruyscher, R. (2005, July). Phage Display In Biotechnology and Drug Discovery, pp. 347–384.
Source: ORCID
Added: January 31, 2019
2003 journal article
Identification and characterization of peptide probes directed against PKCα conformations
The Journal of Peptide Research, 61(5), 263–273.
author keywords: conformational probes; peptide phage display; protein kinase C; surrogate ligands
MeSH headings : Amino Acid Sequence; Binding Sites; Isoenzymes / chemistry; Isoenzymes / metabolism; Molecular Probes / chemistry; Molecular Probes / metabolism; Peptide Library; Peptides / chemistry; Peptides / metabolism; Protein Binding; Protein Kinase C / chemistry; Protein Kinase C / metabolism; Protein Kinase C-alpha
Source: ORCID
Added: January 31, 2019
2003 journal article
Intracellular Expression of Peptide Fusions for Demonstration of Protein Essentiality in Bacteria
Antimicrobial Agents and Chemotherapy, 47(9), 2875–2881.
MeSH headings : Bacterial Proteins / genetics; Bacterial Proteins / physiology; Blotting, Western; Culture Media; DNA Replication; DNA, Bacterial / genetics; DNA, Bacterial / metabolism; DNA, Superhelical / biosynthesis; DNA, Superhelical / genetics; Escherichia coli / growth & development; Escherichia coli / metabolism; Genetic Vectors; Peptide Library; Peptides / metabolism; Plasmids / genetics; Protein Biosynthesis; Reverse Transcriptase Polymerase Chain Reaction; Transcription, Genetic / genetics
Source: ORCID
Added: January 31, 2019
2003 article
Surrogate Ligand-Based Assay Systems for Discovery of Antibacterial Agents for Genomic Targets
Hamilton, P., & Christensen, D. (2003, May). Microbial Genomics and Drug Discovery, pp. 173–185.
Source: ORCID
Added: January 31, 2019
2001 journal article
Identification of Enzyme Inhibitors from Phage-Displayed Combinatorial Peptide Libraries
CCHTS, 4(7), 535–543.
MeSH headings : Amino Acid Sequence; Bacteriophages / drug effects; Bacteriophages / enzymology; Combinatorial Chemistry Techniques; Enzyme Inhibitors / pharmacology; Escherichia coli / enzymology; Ligands; Molecular Sequence Data; Peptide Library; Tetrahydrofolate Dehydrogenase / metabolism
Source: ORCID
Added: January 31, 2019
2001 journal article
Phage display for target-based antibacterial drug discovery
Drug Discovery Today, 6(14), 721–727.
Source: ORCID
Added: January 31, 2019
2000 journal article
Detection of small-molecule enzyme inhibitors with peptides isolated from phage-displayed combinatorial peptide libraries
Chemistry & Biology, 7(1), 17–25.
author keywords: enzyme inhibitors; fluorescence polarization; high-throughput screening; peptide ligand; phage display; time-resolved fluorescence
MeSH headings : Alcohol Dehydrogenase / antagonists & inhibitors; Amino Acid Sequence; Amino Acyl-tRNA Synthetases / antagonists & inhibitors; Bacteriophages / metabolism; Biotin / chemistry; Carboxypeptidase B; Carboxypeptidases / antagonists & inhibitors; Chromatography, Affinity; Enzyme Inhibitors / analysis; Enzyme Inhibitors / isolation & purification; Enzyme Inhibitors / pharmacology; Enzyme-Linked Immunosorbent Assay; Haemophilus influenzae / enzymology; Hexokinase / antagonists & inhibitors; Kinetics; Ligands; Molecular Sequence Data; Peptide Library; Phosphorylases / antagonists & inhibitors; Tyrosine-tRNA Ligase / antagonists & inhibitors; beta-Glucosidase / antagonists & inhibitors
Source: ORCID
Added: January 31, 2019
1999 journal article
Dissection of the LXXLL Nuclear Receptor-Coactivator Interaction Motif Using Combinatorial Peptide Libraries: Discovery of Peptide Antagonists of Estrogen Receptors α and β
Mol. Cell. Biol., 19(12), 8226–8239.
MeSH headings : Amino Acid Sequence; Binding Sites; Estrogen Receptor alpha; Estrogen Receptor beta; HeLa Cells; Humans; Ligands; Molecular Sequence Data; Peptide Library; Peptides / metabolism; Receptors, Cytoplasmic and Nuclear / metabolism; Receptors, Estrogen / genetics; Receptors, Estrogen / metabolism; Recombinant Fusion Proteins / genetics; Recombinant Fusion Proteins / metabolism; Transcription, Genetic; Tumor Cells, Cultured
Source: ORCID
Added: January 31, 2019
1999 journal article
Estrogen receptor (ER) modulators each induce distinct conformational changes in ER and ER
Proceedings of the National Academy of Sciences, 96(7), 3999–4004.
MeSH headings : Amino Acid Sequence; Binding Sites; Estradiol / pharmacology; Estradiol Congeners / pharmacology; Estriol / pharmacology; Estrogen Antagonists / pharmacology; Estrogen Receptor alpha; Estrogen Receptor beta; Estrogens / pharmacology; Humans; Molecular Sequence Data; Protein Conformation / drug effects; Receptors, Estrogen / chemistry; Receptors, Estrogen / drug effects; Sequence Alignment; Sequence Homology, Amino Acid; Tamoxifen / analogs & derivatives; Tamoxifen / pharmacology
Source: ORCID
Added: January 31, 2019
1999 journal article
Peptide antagonists of the human estrogen receptor
Science, 285(5428), 744–746.
MeSH headings : Amino Acid Sequence; Binding Sites; Estradiol / metabolism; Estradiol / pharmacology; Estrogen Antagonists / pharmacology; Estrogen Receptor alpha; Humans; Ligands; Mifepristone / pharmacology; Molecular Sequence Data; Peptide Library; Peptides / metabolism; Peptides / pharmacology; Receptors, Cytoplasmic and Nuclear / metabolism; Receptors, Estrogen / agonists; Receptors, Estrogen / antagonists & inhibitors; Receptors, Estrogen / chemistry; Receptors, Estrogen / metabolism; Recombinant Fusion Proteins / pharmacology; Tamoxifen / metabolism; Tamoxifen / pharmacology; Transcription Factor AP-1 / genetics; Transcription Factor AP-1 / metabolism; Transcription, Genetic / drug effects
Source: ORCID
Added: February 1, 2019
1995 article
Applying Genetic Engineering to the Structural Analysis of Proteins
Physical Methods to Characterize Pharmaceutical Proteins, pp. 329–350.
MeSH headings : Amino Acid Sequence; Base Sequence; Biotechnology; Cloning, Molecular; Coliphages / genetics; DNA, Recombinant / genetics; Escherichia coli / genetics; Gene Expression; Genetic Vectors; Molecular Sequence Data; Mutagenesis; Polymerase Chain Reaction; Protein Engineering / methods; Proteins / chemistry; Proteins / genetics; Recombinant Fusion Proteins / chemistry; Recombinant Fusion Proteins / genetics; Recombinant Fusion Proteins / isolation & purification; Technology, Pharmaceutical
Source: ORCID
Added: January 31, 2019
1995 journal article
Applying genetic engineering to the structural analysis of proteins.
Pharmaceutical Biotechnology, 7, 329–350. http://www.scopus.com/inward/record.url?eid=2-s2.0-0029449448&partnerID=MN8TOARS
Source: ORCID
Added: February 1, 2019
1993 journal article
Expression of a single-chain antibody as a maltose binding protein fusion
Protein Engineering, Design and Selection, 6, 88.
Source: ORCID
Added: February 1, 2019
1989 journal article
A hydrogenase-linked gene in Methanobacterium thermoautotrophicum strain delta H encodes a polyferredoxin.
Proceedings of the National Academy of Sciences, 86(9), 3031–3035.
MeSH headings : Amino Acid Sequence; Base Sequence; Biological Evolution; Cloning, Molecular; Codon; Euryarchaeota / enzymology; Euryarchaeota / genetics; Ferredoxins / genetics; Genes, Bacterial; Hydrogenase / genetics; Molecular Sequence Data; Operon; Polymers; Transcription, Genetic
Source: ORCID
Added: January 31, 2019
1989 journal article
Nucleotide sequence of the major outer membrane protein gene from Chlamydia trachomatis serovar H
Nucl Acids Res, 17(20), 8366–8366.
MeSH headings : Amino Acid Sequence; Bacterial Outer Membrane Proteins / genetics; Base Sequence; Chlamydia trachomatis / genetics; Genes, Bacterial; Molecular Sequence Data
Source: ORCID
Added: January 31, 2019
1989 journal article
Polyferredoxin: A methanogen hydrogenase operon encodes a gene for a 12 × (4Fe4S) protein
Journal of Inorganic Biochemistry, 36(3-4), 221.
Source: ORCID
Added: January 31, 2019
1987 article
Divergence of Methanogens, Conservation of the His I Gene Sequence in all Three Biological Kingdoms and the Status of Methanobacterium Thermoautotrophicum
Microbial Growth on C1 Compounds, pp. 255–260.
Source: ORCID
Added: January 31, 2019
1986 journal article
Structure of methanogen genes
Systematic and Applied Microbiology, 7(1), 5–12.
Source: ORCID
Added: January 31, 2019
1985 journal article
Sequence divergence of an archaebacterial gene cloned from a mesophilic and a thermophilic methanogen
J Mol Evol, 22(4), 351–360.
MeSH headings : Amino Acid Sequence; Base Composition; Base Sequence; Biological Evolution; Cloning, Molecular; Escherichia coli / genetics; Euryarchaeota / genetics; Genes; Genes, Bacterial; Genetic Variation; Genotype; Phenotype; Plasmids; Species Specificity
Source: ORCID
Added: January 31, 2019
1985 journal article
Structure of genes and an insertion element in the methane producing archaebacterium Methanobrevibacter smithii
Molec. Gen. Genet., 200(1), 47–59.
MeSH headings : Amino Acid Sequence; Archaea / genetics; Bacteria / genetics; Bacterial Proteins / genetics; Base Sequence; Cloning, Molecular; Codon; DNA Restriction Enzymes; DNA Transposable Elements; Escherichia coli / genetics; Genes; Genes, Bacterial; Genotype; Methane / metabolism; Mutation; Nucleic Acid Hybridization; Phenotype
Source: ORCID
Added: January 31, 2019
1982 journal article
Beginning genetics with methanogens.
Basic Life Sciences, 19, 233–244. http://www.scopus.com/inward/record.url?eid=2-s2.0-0020009847&partnerID=MN8TOARS
Source: ORCID
Added: February 1, 2019
Employment
Updated: July 5th, 2016 10:20
2009 - present
North Carolina State University Raleigh, NC, US
Associate Professor
Plant and Microbial Biology
Education
Updated: July 5th, 2016 10:27
1980 - 1984
Ohio State University Columbus, OH, US
Ph.D in Microbiology
Microbiology
1976 - 1980
University of Michigan Ann Arbor, MI, US
Bachelor of Science in Microbiology
Funding History
Funding history based on the linked ORCID record. Updated: December 10th, 2019 19:37
grant
September 1, 2019 - August 1, 2022
NSF IGE: Accelerate to Industry (A2i)
National Science Foundation
grant
September 15, 2015 - May 31, 2016
I-Corps: Industrial Enzymes from the Microbiomes of Household Insects
National Science Foundation - Directorate for Engineering
grant
May 15, 2008 - April 30, 2009
Antibiotic-binding Peptides for Biofilm Prevention on Ventriculoperitoneal Shunts
National Institute of Neurological Disorders and Stroke
grant
May 15, 2008 - April 30, 2009
Antibiotic-binding Peptides for Biofilm Prevention on Ventriculoperitoneal Shunts
National Institute of Neurological Disorders and Stroke
grant
April 14, 2008 - August 1, 2009
Localized Growth Factor Therapy for Surgical Hernia Repair
National Institute of General Medical Sciences
grant
April 14, 2008 - August 1, 2009
Localized Growth Factor Therapy for Surgical Hernia Repair
National Institute of General Medical Sciences
grant
September 20, 2007 - August 31, 2010
Interfacial Adapters for Improved Cell Delivery to Tissues
National Heart Lung and Blood Institute
grant
July 2, 2007 - June 30, 2008
Point of Care Attachment of Multiple Antibiotics onto Metal Implants
National Institute of Dental and Craniofacial Research
grant
July 2, 2007 - July 31, 2011
Point of Care Attachment of Antibiotics onto Metal Implants
National Institute of Allergy and Infectious Diseases
grant
July 2, 2007 - June 30, 2008
Point of Care Attachment of Multiple Antibiotics onto Metal Implants
National Institute of Dental and Craniofacial Research
grant
September 30, 2006 - September 29, 2008
Discovery of a Platelet Derived Growth Factor Peptide-based Mimetic
National Institute of Diabetes and Digestive and Kidney Diseases
grant
September 30, 2006 - September 29, 2008
Discovery of a Platelet Derived Growth Factor Peptide-based Mimetic
National Institute of Diabetes and Digestive and Kidney Diseases
grant
September 1, 2006 - August 31, 2007
Injectable BMP-2 Formulation for Fracture Healing
National Institute of Arthritis and Musculoskeletal and Skin Diseases
grant
September 1, 2006 - August 31, 2007
Injectable BMP-2 Formulation for Fracture Healing
National Institute of Arthritis and Musculoskeletal and Skin Diseases
grant
June 28, 2006 - March 31, 2008
Growth Factor Coated Sutures for Improved Tendons Repair
National Institute of Arthritis and Musculoskeletal and Skin Diseases
grant
June 28, 2006 - March 31, 2008
Growth Factor Coated Sutures for Improved Tendons Repair
National Institute of Arthritis and Musculoskeletal and Skin Diseases
grant
July 1, 2005 - June 30, 2007
Discovery of Peptide-based Bone Morphogenic Protein Mimetics
National Institute of Arthritis and Musculoskeletal and Skin Diseases
grant
July 1, 2005 - June 30, 2007
Discovery of Peptide-based Bone Morphogenic Protein Mimetics
National Institute of Arthritis and Musculoskeletal and Skin Diseases
grant
April 1, 2005 - March 31, 2006
Improved Orthopedic Implant Surface Coatings
National Institute of Arthritis and Musculoskeletal and Skin Diseases
grant
April 1, 2005 - March 31, 2006
Improved Orthopedic Implant Surface Coatings
National Institute of Arthritis and Musculoskeletal and Skin Diseases
grant
April 1, 2004 - August 31, 2009
Improved Orthopedic Implant Surface Coatings
National Institute of Arthritis and Musculoskeletal and Skin Diseases
grant
April 1, 2004 - August 31, 2009
Improved Orthopedic Implant Surface Coatings
National Institute of Arthritis and Musculoskeletal and Skin Diseases
grant
September 1, 1999 - February 28, 2001
A NOVEL APPROACH TO THE DISCOVERY OF ANTIBACTERIAL DRUGS
National Institute of Allergy and Infectious Diseases
grant
September 1, 1999 - February 28, 2001
A NOVEL APPROACH TO THE DISCOVERY OF ANTIBACTERIAL DRUGS
National Institute of Allergy and Infectious Diseases
