Pengning Xu

College of Sciences

Works (4)

Updated: April 24th, 2025 08:48

2024 article

Structural and Dynamical Properties of Nucleic Acid Hairpins Implicated in Trinucleotide Repeat Expansion Diseases

Pan, F., Xu, P., Roland, C., Sagui, C., & Weninger, K. (2024, October 10). Biomolecules, Vol. 14.

By: F. Pan n, P. Xu n, C. Roland n , C. Sagui n  & K. Weninger n 

author keywords: trinucleotide repeats; expansion diseases; hairpin structure; single-molecule FRET; smFRET; molecular dynamics simulations; CAG and GAC; CTG and GTC
MeSH headings : Trinucleotide Repeat Expansion / genetics; Humans; Nucleic Acid Conformation; DNA / chemistry; DNA / metabolism; DNA / genetics; Molecular Dynamics Simulation; Trinucleotide Repeats / genetics; Fluorescence Resonance Energy Transfer
topics (OpenAlex): Genetic Neurodegenerative Diseases; Genetics and Neurodevelopmental Disorders; DNA Repair Mechanisms
UN Sustainable Development Goals Color Wheel
UN Sustainable Development Goal Categories
Sources: Web Of Science, NC State University Libraries
Added: November 12, 2024

2022 article

A blind benchmark of analysis tools to infer kinetic rate constants from single-molecule FRET trajectories

Götz, M., Barth, A., Bohr, S. S.-R., Börner, R., Chen, J., Cordes, T., … Schmid, S. (2022, September 14). Nature Communications, Vol. 9.

By: M. Götz *, A. Barth *, S. Bohr *, R. Börner *, J. Chen *, T. Cordes *, D. Erie *, C. Gebhardt * ...

MeSH headings : Benchmarking; Fluorescence Resonance Energy Transfer / methods; Kinetics; Models, Theoretical
topics (OpenAlex): ATP Synthase and ATPases Research; Advanced Fluorescence Microscopy Techniques; Advanced Electron Microscopy Techniques and Applications
TL;DR: A blind benchmark study assessing eleven analysis tools used to infer kinetic rate constants from smFRET trajectories, testing on simulated and experimental data and identifying key targets for future developments to advance the understanding of biomolecular dynamics. (via Semantic Scholar)
UN Sustainable Development Goals Color Wheel
UN Sustainable Development Goal Categories
Sources: Web Of Science, NC State University Libraries
Added: October 3, 2022

2021 article

Molecular conformations and dynamics of nucleotide repeats associated with neurodegenerative diseases: double helices and CAG hairpin loops

Pan, F., Zhang, Y., Xu, P., Man, V. H., Roland, C., Weninger, K., & Sagui, C. (2021, January 1). Computational and Structural Biotechnology Journal, Vol. 19, pp. 2819–2832.

By: F. Pan*, Y. Zhang *, P. Xu n, V. Man n, C. Roland n , K. Weninger n , C. Sagui n 

author keywords: Trinucleotide hexanucleotide repeats; CAG; GAC; CTG; CUG; CCG; GGC; GGGGCC; GGCCCC; Hairpin loops; smFRET; Molecular dynamics
topics (OpenAlex): Genetic Neurodegenerative Diseases; Neurogenetic and Muscular Disorders Research; RNA Research and Splicing
UN Sustainable Development Goals Color Wheel
UN Sustainable Development Goal Categories
Sources: Web Of Science, NC State University Libraries
Added: August 30, 2021

2021 article

Structure, dynamics, and regulation of TRF1-TIN2-mediated trans- and cis-interactions on telomeric DNA

Pan, H., Kaur, P., Barnes, R., Detwiler, A. C., Sanford, S. L., Liu, M., … Wang, H. (2021, August 14). Journal of Biological Chemistry, Vol. 9.

By: H. Pan n, P. Kaur n, R. Barnes *, A. Detwiler *, S. Sanford *, M. Liu  n, P. Xu n, C. Mahn n ...

MeSH headings : Cell Adhesion Molecules / metabolism; Cell Adhesion Molecules / physiology; DNA / metabolism; DNA-Binding Proteins / metabolism; Humans; Microscopy, Atomic Force / methods; Models, Molecular; Multiprotein Complexes / metabolism; Protein Binding; Protein Isoforms / metabolism; Shelterin Complex / metabolism; Shelterin Complex / physiology; Telomere / metabolism; Telomere-Binding Proteins / metabolism; Telomere-Binding Proteins / physiology; Telomeric Repeat Binding Protein 1 / metabolism; Telomeric Repeat Binding Protein 1 / physiology; Telomeric Repeat Binding Protein 2 / metabolism; Telomeric Repeat Binding Protein 2 / physiology
topics (OpenAlex): Telomeres, Telomerase, and Senescence; DNA Repair Mechanisms; Genomics and Chromatin Dynamics
TL;DR: Analysis of DNA molecular structures promoted by TRF1-TIN2 interaction supports a molecular model in which protein assemblies at telomeres are heterogeneous with distinct subcomplexes and full shelterin complexes playing distinct roles in telomere protection and elongation. (via Semantic Scholar)
UN Sustainable Development Goals Color Wheel
UN Sustainable Development Goal Categories
Sources: Web Of Science, NC State University Libraries
Added: October 26, 2021

Citation Index includes data from a number of different sources. If you have questions about the sources of data in the Citation Index or need a set of data which is free to re-distribute, please contact us.

Certain data included herein are derived from the Web of Science© and InCites© (2026) of Clarivate Analytics. All rights reserved. You may not copy or re-distribute this material in whole or in part without the prior written consent of Clarivate Analytics.