Quibria Guthrie

Works (4)

Updated: July 5th, 2023 15:34

2022 journal article

Aligned peptoid-based macrodiscs for structural studies of membrane proteins by oriented-sample NMR

BIOPHYSICAL JOURNAL, 121(17), 3263–3270.

By: A. Galiakhmetov n, C. Davern n, R. Esteves n, E. Awosanya n, Q. Guthrie n, C. Proulx n , A. Nevzorov n

MeSH headings : Glycine; Lipids; Magnetic Resonance Spectroscopy; Membrane Proteins / chemistry; Peptoids / chemistry
TL;DR: The NMR spectra measured for the membrane-bound form of Pf1 coat protein incorporated in this new lipid mimetics demonstrate a higher order parameter and uniform linewidths as compared to the conventional bicelles and peptide-based macrodiscs. (via Semantic Scholar)
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Sources: Web Of Science, NC State University Libraries
Added: October 11, 2022

2019 journal article

Ketoxime peptide ligations: oxidative couplings of alkoxyamines to N-aryl peptides

CHEMICAL SCIENCE, 10(41), 9506–9512.

By: Q. Guthrie n, H. Young n & C. Proulx n 

TL;DR: Ketoxime peptides are readily accessible from oxidative couplings between N-aryl peptides and alkoxyamines under catalyst-free conditions. (via Semantic Scholar)
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Sources: Web Of Science, NC State University Libraries
Added: November 18, 2019

2019 journal article

N-Arylation of Amino Acid Esters to Expand Side Chain Diversity in Ketoxime Peptide Ligations

JOURNAL OF ORGANIC CHEMISTRY, 85(3), 1748–1755.

By: H. Young n, Q. Guthrie n & C. Proulx n 

TL;DR: Palladium-catalyzed N-arylations of amino acid tert-butyl esters using 4-bromo-N,N-dimethylaniline as a coupling partner are reported, increasing the scope of Cα-substitution in ketoxime peptides. (via Semantic Scholar)
Sources: Web Of Science, NC State University Libraries
Added: March 16, 2020

2018 journal article

Oxime Ligation via in situ Oxidation of N-Phenylglycinyl Peptides

ORGANIC LETTERS, 20(9), 2564–2567.

By: Q. Guthrie n & C. Proulx n 

MeSH headings : Molecular Structure; Oxidation-Reduction; Oximes / chemistry; Peptides
TL;DR: Mild conditions for oxime ligations via in situ generation of α-imino amide intermediates, which can be fine-tuned by the electronic properties of the N-phenylglycine residue, offer unique advantages over conventional approaches for oximes ligations. (via Semantic Scholar)
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Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018

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