Quibria Guthrie

Works (4)

Updated: July 5th, 2023 15:34

2022 article

Aligned peptoid-based macrodiscs for structural studies of membrane proteins by oriented-sample NMR

Galiakhmetov, A. R., Davern, C. M., Esteves, R. J. A., Awosanya, E. O., Guthrie, Q. A. E., Proulx, C., & Nevzorov, A. A. (2022, August 2). Biophysical Journal, Vol. 9.

By: A. Galiakhmetov n, C. Davern n, R. Esteves n, E. Awosanya n, Q. Guthrie n, C. Proulx n , A. Nevzorov n

MeSH headings : Glycine; Lipids; Magnetic Resonance Spectroscopy; Membrane Proteins / chemistry; Peptoids / chemistry
topics (OpenAlex): Chemical Synthesis and Analysis; RNA and protein synthesis mechanisms; DNA and Nucleic Acid Chemistry
TL;DR: The NMR spectra measured for the membrane-bound form of Pf1 coat protein incorporated in this new lipid mimetics demonstrate a higher order parameter and uniform linewidths as compared to the conventional bicelles and peptide-based macrodiscs. (via Semantic Scholar)
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Sources: Web Of Science, NC State University Libraries
Added: October 11, 2022

2019 article

N-Arylation of Amino Acid Esters to Expand Side Chain Diversity in Ketoxime Peptide Ligations

Young, H. A., Guthrie, Q. A. E., & Proulx, C. (2019, December 3). The Journal of Organic Chemistry, Vol. 85, pp. 1748–1755.

By: H. Young n, Q. Guthrie n & C. Proulx n 

topics (OpenAlex): Chemical Synthesis and Analysis; Click Chemistry and Applications; Peptidase Inhibition and Analysis
TL;DR: Palladium-catalyzed N-arylations of amino acid tert-butyl esters using 4-bromo-N,N-dimethylaniline as a coupling partner are reported, increasing the scope of Cα-substitution in ketoxime peptides. (via Semantic Scholar)
Sources: Web Of Science, NC State University Libraries
Added: March 16, 2020

2019 article

Ketoxime peptide ligations: oxidative couplings of alkoxyamines to N-aryl peptides

Guthrie, Q. A. E., Young, H. A., & Proulx, C. (2019, January 1). Chemical Science, Vol. 10, pp. 9506–9512.

By: Q. Guthrie n, H. Young n & C. Proulx n 

topics (OpenAlex): Chemical Synthesis and Analysis; Click Chemistry and Applications
TL;DR: Ketoxime peptides are readily accessible from oxidative couplings between N-aryl peptides and alkoxyamines under catalyst-free conditions. (via Semantic Scholar)
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Sources: Web Of Science, NC State University Libraries
Added: November 18, 2019

2018 article

Oxime Ligation via in situ Oxidation of N-Phenylglycinyl Peptides

Guthrie, Q. A. E., & Proulx, C. (2018, April 25). Organic Letters, Vol. 20, pp. 2564–2567.

By: Q. Guthrie n & C. Proulx n 

MeSH headings : Molecular Structure; Oxidation-Reduction; Oximes / chemistry; Peptides
topics (OpenAlex): Chemical Synthesis and Analysis; Click Chemistry and Applications; Synthesis and Catalytic Reactions
TL;DR: Mild conditions for oxime ligations via in situ generation of α-imino amide intermediates, which can be fine-tuned by the electronic properties of the N-phenylglycine residue, offer unique advantages over conventional approaches for oximes ligations. (via Semantic Scholar)
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Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018

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