@article{ruan_hu_wen_chen_chen_lu_wang_cheng_lu_gu_2019, title={A Dual-Bioresponsive Drug-Delivery Depot for Combination of Epigenetic Modulation and Immune Checkpoint Blockade}, volume={31}, ISSN={["1521-4095"]}, DOI={10.1002/adma.201806957}, abstractNote={Abstract}, number={17}, journal={ADVANCED MATERIALS}, author={Ruan, Huitong and Hu, Quanyin and Wen, Di and Chen, Qian and Chen, Guojun and Lu, Yifei and Wang, Jinqiang and Cheng, Hao and Lu, Weiyue and Gu, Zhen}, year={2019}, month={Apr} }
 @article{yang_chen_wen_chen_wang_chen_wang_zhang_zhang_hu_et al._2019, title={A Therapeutic Microneedle Patch Made from Hair-Derived Keratin for Promoting Hair Regrowth}, volume={13}, ISSN={["1936-086X"]}, DOI={10.1021/acsnano.8b09573}, abstractNote={Activating hair follicle stem cells (HFSCs) to promote hair follicle regrowth holds promise for hair loss therapy, while challenges still remain to develop a scenario that enables enhanced therapeutic efficiency and easy administration. Here we describe a detachable microneedle patch-mediated drug delivery system, mainly made from hair-derived keratin, for sustained delivery of HFSC activators. It was demonstrated that this microneedle device integrated with mesenchymal stem cell (MSC)-derived exosomes and a small molecular drug, UK5099, could enhance the treatment efficiency at a reduced dosage, leading to promoted pigmentation and hair regrowth within 6 days through two rounds of administration in a mouse model. This microneedle-based transdermal drug delivery approach shows augmented efficacy compared to the subcutaneous injection of exosomes and topical administration of UK5099.}, number={4}, journal={ACS NANO}, author={Yang, Guang and Chen, Qian and Wen, Di and Chen, Zhaowei and Wang, Jinqiang and Chen, Guojun and Wang, Zejun and Zhang, Xudong and Zhang, Yuqi and Hu, Quanyin and et al.}, year={2019}, month={Apr}, pages={4354–4360} }
 @article{chen_chen_chen_shen_zhang_wang_chan_gu_2019, title={Bioresponsive Protein Complex of aPD1 and aCD47 Antibodies for Enhanced Immunotherapy}, volume={19}, ISSN={["1530-6992"]}, DOI={10.1021/acs.nanolett.9b00584}, abstractNote={Despite the promising efficacy of immune checkpoint blockade (ICB) in treating many types of cancers, the clinical benefits have often been restricted by the low objective response rates and systemic immune-related adverse events. Here, a bioresponsive ICB treatment is developed based on the reactive oxygen species (ROS)-sensitive protein complex for controlled sequential release of anti- "don't eat me" signal antibody (aCD47) and antiprogrammed cell death protein 1 (aPD1), by leveraging the abundant ROS in the tumor microenvironment (TME). These protein complexes can also act as scavengers of ROS in the TME to reverse the immunosuppressive responses, thereby enhancing antitumor efficacy in vivo. In a melanoma cancer model, the synergistic antitumor efficacy was achieved, which was accompanied by enhanced T cell immune responses together with reduced immunosuppressive responses.}, number={8}, journal={NANO LETTERS}, author={Chen, Qian and Chen, Guojun and Chen, Jiawen and Shen, Jingjing and Zhang, Xudong and Wang, Jinqiang and Chan, Amanda and Gu, Zhen}, year={2019}, month={Aug}, pages={4879–4889} }
 @article{chen_wang_zhang_chen_hu_li_wang_wen_zhang_lu_et al._2019, title={In situ sprayed bioresponsive immunotherapeutic gel for post-surgical cancer treatment}, volume={14}, ISSN={["1748-3395"]}, DOI={10.1038/s41565-018-0319-4}, abstractNote={Cancer recurrence after surgical resection remains a significant cause of treatment failure. Here, we have developed an in situ formed immunotherapeutic bioresponsive gel that controls both local tumour recurrence after surgery and development of distant tumours. Briefly, calcium carbonate nanoparticles pre-loaded with the anti-CD47 antibody are encapsulated in the fibrin gel and scavenge H+ in the surgical wound, allowing polarization of tumour-associated macrophages to the M1-like phenotype. The released anti-CD47 antibody blocks the 'don't eat me' signal in cancer cells, thereby increasing phagocytosis of cancer cells by macrophages. Macrophages can promote effective antigen presentation and initiate T cell mediated immune responses that control tumour growth. Our findings indicate that the immunotherapeutic fibrin gel 'awakens' the host innate and adaptive immune systems to inhibit both local tumour recurrence post surgery and potential metastatic spread.}, number={1}, journal={NATURE NANOTECHNOLOGY}, author={Chen, Qian and Wang, Chao and Zhang, Xudong and Chen, Guojun and Hu, Quanyin and Li, Hongjun and Wang, Jinqiang and Wen, Di and Zhang, Yuqi and Lu, Yifei and et al.}, year={2019}, month={Jan}, pages={89-+} }
 @article{chen_hu_dukhovlinova_chen_ahn_wang_ogunnaike_ligler_dotti_gu_2019, title={Photothermal Therapy Promotes Tumor Infiltration and Antitumor Activity of CAR T Cells}, volume={31}, ISSN={["1521-4095"]}, DOI={10.1002/adma.201900192}, abstractNote={Abstract}, number={23}, journal={ADVANCED MATERIALS}, author={Chen, Qian and Hu, Quanyin and Dukhovlinova, Elena and Chen, Guojun and Ahn, Sarah and Wang, Chao and Ogunnaike, Edikan A. and Ligler, Frances S. and Dotti, Gianpietro and Gu, Zhen}, year={2019}, month={Jun} }
 @article{yan_zhang_liu_ye_yu_chen_wang_zhang_hu_kang_et al._2019, title={Shape-controlled synthesis of liquid metal nanodroplets for photothermal therapy}, volume={12}, ISSN={["1998-0000"]}, DOI={10.1007/s12274-018-2262-y}, number={6}, journal={NANO RESEARCH}, author={Yan, Junjie and Zhang, Xudong and Liu, Yang and Ye, Yanqi and Yu, Jicheng and Chen, Qian and Wang, Jinqiang and Zhang, Yuqi and Hu, Quanyin and Kang, Yang and et al.}, year={2019}, month={Jun}, pages={1313–1320} }
 @article{zhang_zhang_gardner_yan_wu_tian_chen_ti_2018, title={A method for determining density based on gamma ray and fast neutron detection using a Cs2LiYCl6 detector in neutron-gamma density logging}, volume={142}, ISSN={["0969-8043"]}, DOI={10.1016/j.apradiso.2018.09.011}, abstractNote={With the increasing demand for radioisotope-free operations, pulsed neutron-gamma density (NGD) has become increasingly important for logging-while-drilling (LWD) development. However, current NGD tools, adopting the multiple-detector array design, are not conducive to the simplification of instrument design and measurement system. To break obstacles, based on the fast neutron-gamma coupled theory, a new density measurement method was proposed. Further, combined with the neutron-gamma simultaneous detection characteristics of the Cs2LiYCl6 (CLYC) detector, an NGD measurement system consisting of a D-T source and one CLYC detector was used. Results show that the new method is capable of determining formation density using a single CLYC detector, which can not only avoid complex instrument systems but also improve density sensitivity. Moreover, the applicability of the new density method was well verified by Monte Carlo simulation. Additionally, the method was successfully applied in a simulated well, and density results are in good agreement with the benchmarked formations. The research provides theoretical guidance for NGD instrument design.}, journal={APPLIED RADIATION AND ISOTOPES}, author={Zhang, Quanying and Zhang, Feng and Gardner, Robin P. and Yan, Huizhong and Wu, Guoli and Tian, Lili and Chen, Qian and Ti, Yongzhou}, year={2018}, month={Dec}, pages={77–84} }
 @article{hu_chen_gu_2018, title={Advances in transformable drug delivery systems}, volume={178}, ISSN={["1878-5905"]}, DOI={10.1016/j.biomaterials.2018.03.056}, abstractNote={These years, transformable drug delivery systems (DDSs), which hold the capability of changing formulation morphology and subsequent functionality at the desired disease site, have shown great promise in control of spatio-temporal drug delivery/release manner and enhanced treatment efficacy. Equipped with controllability and design flexibility, the transformable DDSs are being increasingly pursued for the development of precision drug delivery platforms for biomedical applications. In this review, we describe the recently developed intracelluarly and extracellularly transformable DDSs, especially associated with assembly or disassociation of the original formulation units, for achieving various functionalities, including prolonged retention time, inhibited endocytosis and enhanced cytotoxicity. Furthermore, the different stimuli, such as pH, enzyme, light, temperature, redox and mechanical force that trigger the transformation process are also introduced. The future outlook and challenges are discussed in the end.}, journal={BIOMATERIALS}, author={Hu, Quanyin and Chen, Qian and Gu, Zhen}, year={2018}, month={Sep}, pages={546–558} }
 @article{chen_wang_chen_hu_gu_2018, title={Delivery Strategies for Immune Checkpoint Blockade}, volume={7}, ISSN={["2192-2659"]}, DOI={10.1002/adhm.201800424}, abstractNote={Abstract}, number={20}, journal={ADVANCED HEALTHCARE MATERIALS}, author={Chen, Qian and Wang, Chao and Chen, Guojun and Hu, Quanyin and Gu, Zhen}, year={2018}, month={Oct} }
 @article{zhang_zhang_gardner_liu_zhang_qiu_chen_tian_wang_2018, title={Quantitative monitoring of CO2 sequestration using thermal neutron detection technique in heavy oil reservoirs}, volume={79}, ISSN={["1878-0148"]}, DOI={10.1016/j.ijggc.2018.10.003}, abstractNote={CO2 enhanced oil recovery (CO2-EOR) project is of significance for CO2 sequestration and heavy oil recovery. Quantitative monitoring of CO2 saturation (SCO2) is essential to recognizing and understanding the migration and distribution of CO2 injected into the geological formations. In this paper, based on the difference in the neutron moderation ability of CO2, water and heavy oil, thermal neutron detection technique is applied in heavy oil reservoirs to monitor CO2 sequestration. By Monte Carlo simulation, the responses of thermal neutron count ratio versus different porosities and CO2 saturation were studied. Then, a mathematical model of CO2 saturation versus thermal neutron count ratio and formation porosity was established to quantitatively calculate CO2 saturation. Besides, the effects of formation pressure and temperature, heavy oil density, lithology, and other factors on the method were studied. Results show that variations of formation pressure, formation temperature, and density of heavy oil have little impact on the CO2 saturation measurement. However, the change of formation lithology results in larger CO2 saturation errors and needs corrections. In addition, the method has a low discrimination between CO2 and CH4 gas, and the results are easily affected by the CH4 content. Finally, a simulated case demonstrates the application of the method. For the heavy-oil sandstone with different porosities, the method shows a perfect performance: the SCO2 errors are less than 1% for the high and low gas saturated formation. This research provides an effective strategy to monitor CO2 storage and residual oil saturation in CO2-EOR reservoirs.}, journal={INTERNATIONAL JOURNAL OF GREENHOUSE GAS CONTROL}, author={Zhang, Feng and Zhang, Quanying and Gardner, Robin P. and Liu, Juntao and Zhang, Xiaoyang and Qiu, Fei and Chen, Qian and Tian, Lili and Wang, Yang}, year={2018}, month={Dec}, pages={154–164} }
 @article{chen_huang_2012, title={A Low-Loss Gate Drive for Emitter Turn-Off Thyristor (ETO)}, volume={27}, ISSN={["1941-0107"]}, DOI={10.1109/tpel.2012.2203146}, abstractNote={This letter introduces a new and energy-efficient gate drive circuit for emitter turn-off thyristor (ETO). The proposed circuit is a buck converter with two controllers that obtains power from gate current when the ETO gate voltage is negative, thus reducing power dissipation of the ETO gate drive and significantly mitigating a limitation of current ETO self-power designs. Various on-state gate current circuits are discussed and simulated. Experimental results verify the proposed circuit's operation and low-power consumption performance. The proposed circuit can be used in integrated gate-commutated thyristor and gate-commutated thyristor as well.}, number={12}, journal={IEEE TRANSACTIONS ON POWER ELECTRONICS}, author={Chen, Qian and Huang, Alex Q.}, year={2012}, month={Dec}, pages={4827–4831} }
 @inproceedings{chen_tan_huang_2012, title={Self-power emitter turn-off thyristor (SPETO) based circuit breaker for power distribution system}, DOI={10.1109/ecce.2012.6342564}, abstractNote={Compared to mechanical solution, solid-state circuit breaker (SSCB) offers enormous advantages in terms of switching speed and maintenance. With fast switching performance, high current turn-off capability, self-power and built-in sensor functions, SPETO is a very promising high power switching device for the application of SSCB in power distribution system. The experimental results show that the SPETO based SSCB can turn off current quickly and works well with self-power function, and therefore is suitable for SSCB in power distribution system.}, booktitle={2012 IEEE Energy Conversion Congress and Exposition (ECCE)}, author={Chen, Q. and Tan, K. and Huang, A. Q.}, year={2012}, pages={2017–2021} }
 @inproceedings{chen_huang_2011, title={Analysis of impact of self-power function on emitter turn-off thyristor}, DOI={10.1109/ecce.2011.6064013}, abstractNote={Self-power emitter turn-off thyristor (SPETO) is a high power switching device which could provide power for its gate drive during operation. Self-power function reduces the system cost and makes the mechanical structure compact, whereas it may bring extra harmonic when SPETO is to be utilized in high power utilities. In this paper, the impact of self-power function on extra harmonic is analyzed; the ideas to attenuate the impact are presented and verified by the analysis, simulation and experimental results.}, booktitle={2011 IEEE Energy Conversion Congress and Exposition (ECCE)}, author={Chen, Q. and Huang, A. Q.}, year={2011}, pages={1868–1872} }
 @inproceedings{chen_huang_2010, title={Improvement of gate drive for self-power emitter turn-off thyristor (speto)}, DOI={10.1109/iecon.2010.5675201}, abstractNote={Self-power emitter turn-off thyristor (SPETO) is a high power switching device which could provide power for its gate drive during operation. Self-power function reduces the system cost and makes the mechanical structure compact, whereas it may bring extra harmonic when SPETO is being utilized in power utilities. In this paper, the impact of self-power function on extra harmonic is analyzed. The ideas to improve SPETO gate drive hence reduce extra harmonic are presented and verified by simulation.}, booktitle={Iecon 2010: 36th annual conference of the ieee industrial electronics society}, author={Chen, Q. A. and Huang, A. Q.}, year={2010} }