Qingyang Liu

Works (2)

Updated: July 5th, 2023 15:43

2015 journal article

Conditional Control of Alternative Splicing through Light-Triggered Splice-Switching Oligonucleotides

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 137(10), 3656–3662.

By: J. Hemphill n, Q. Liu n, R. Uprety n, S. Samanta *, M. Tsang *, R. Juliano*, A. Deiters n

MeSH headings : Alternative Splicing / radiation effects; Animals; HeLa Cells; Humans; Light; Oligonucleotides / chemistry; Oligonucleotides / genetics; Zebrafish
TL;DR: This work addressed site-specific installation of light-removable nucleobase-caging groups as well as photocleavable backbone linkers into synthetic SSOs that enables optochemical OFF → ON and ON → OFF switching of their activity and thus precise control of alternative splicing. (via Semantic Scholar)
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Added: August 6, 2018

2013 review

Optochemical Control of Deoxyoligonucleotide Function via a Nucleobase-Caging Approach

[Review of ]. ACCOUNTS OF CHEMICAL RESEARCH, 47(1), 45–55.

By: Q. Liu n & A. Deiters n

MeSH headings : Base Sequence; DNA, Catalytic / genetics; DNA, Catalytic / metabolism; Humans; Light; Oligonucleotides / chemistry; Oligonucleotides / metabolism; Photochemical Processes; Proteins / metabolism; RNA / chemistry; RNA / metabolism
TL;DR: The application of caged nucleobases to the photoregulation of DNA function is focused on and light-activated DNA logic operations are developed, an advance that may lay the foundation for the optochemical control of complex DNA calculations. (via Semantic Scholar)
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Added: August 6, 2018

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