Works (17)
Updated: April 4th, 2024 10:12
2023 journal article
Cerebrospinal Fluid Protein Markers Indicate Neuro-Damage in SARS-CoV-2-Infected Nonhuman Primates
Molecular & Cellular Proteomics.
MeSH headings : Animals; Humans; Chlorocebus aethiops; SARS-CoV-2; COVID-19; Cerebrospinal Fluid Proteins; Proteome; Macaca mulatta
TL;DR:
The results indicate that CSF proteome changes after infection resolution correspond with bronchial virus abundance during early infection and revealed substantial differences between the infected NHPs and their age-matched uninfected controls, suggesting these differences could reflect altered secretion of CNS factors in response to SARS-CoV-2-induced neuropathology.
(via Semantic Scholar)
doi.org (publisher)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(OpenAlex)
Source: ORCID
Added: May 2, 2023
2022 journal article
Assay design for unambiguous identification and quantification of circulating pathogen-derived peptide biomarkers
Theranostics.
MeSH headings : Animals; Biomarkers; Mycobacterium tuberculosis; Peptides; Sensitivity and Specificity; Tuberculosis / diagnosis; Tuberculosis / microbiology
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(OpenAlex)
Source: ORCID
Added: May 2, 2023
2022 journal article
MS-based Detection of Pathogen Antigen Through Immunoprecipitation of Its Proteolytic Peptides
Molecular & Cellular Proteomics.
Source: ORCID
Added: May 2, 2023
2022 journal article
Nanopore-based disease diagnosis using pathogen-derived tryptic peptides from serum
Nano Today.
Contributors: W. Zheng *, J. Saliba*, X. Wei *, * , L. Pierson*, L. Mao*, C. Liu *, C. Lyon *
TL;DR:
It is demonstrated that a peptide identified by this approach produced high-affinity antibodies and yielded a characteristic peptide signature that was detectable over a broad linear range, to detect and quantify a pathogen-derived peptide from digested human serum samples with high sensitivity and specificity.
(via Semantic Scholar)
Source: ORCID
Added: May 2, 2023
2022 journal article
Peptidomic analysis of mycobacterial secreted proteins enables species identification
View.
Contributors: * , M. Rajagopal*, J. Fan *, L. Zhan*, X. Kong*, Y. He *, S. Rotcheewaphan *, C. Lyon *
TL;DR:
A novel immunoprecipitation‐coupled mass spectrometry assay that can distinguish Esx proteins that are expressed by slow‐growing mycobacterial species commonly detected in clinical isolates is described.
(via Semantic Scholar)
Source: ORCID
Added: May 2, 2023
2021 journal article
Species-specific quantification of circulating ebolavirus burden using VP40-derived peptide variants
PLOS Pathogens, 17(11), e1010039.
Ed(s): A. Hartman
MeSH headings : Animals; Ebolavirus / immunology; Hemorrhagic Fever, Ebola / blood; Hemorrhagic Fever, Ebola / diagnosis; Hemorrhagic Fever, Ebola / immunology; Hemorrhagic Fever, Ebola / virology; Humans; Macaca mulatta; Peptide Fragments / immunology; Recombinant Proteins / immunology; Species Specificity; Viral Matrix Proteins / immunology
TL;DR:
An immunoprecipitation-coupled mass spectrometry (IP-MS) assay for VP40 antigen detection and quantification that differentiates four of the six known EBV species in one assay, through a combination of p8 and p12 data.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
15. Life on Land
(OpenAlex)
Source: ORCID
Added: May 2, 2023
2020 journal article
Destabilization of exotoxin A diminishes serum antibody titer and affinity maturation by reducing peptide-MHCII abundance
The Journal of Immunology. https://publons.com/wos-op/publon/57950976/
Source: ORCID
Added: May 2, 2023
2020 article
IP-MS Analysis of ESX-5 and ESX-1 Substrates Enables Mycobacterial Species Identification
Shu, Q., Rajagopal, M., Fan, J., Zhan, L., Kong, X., He, Y., … Hu, T. (2020, June 7). (Vol. 6). Vol. 6.
TL;DR:
This IP-MS assay employs antibodies specific for conserved tryptic peptides of M. tuberculosis EsxN (AQAASLEAEHQAIVR) and CFP-10 (TQIDQVESTAGSLQGQWR) to capture and identify specific mycobacterial species and allows species-specific myCobacterium identification at the first sign of MGIT culture positivity.
(via Semantic Scholar)
Source: ORCID
Added: May 2, 2023
2020 journal article
Large-scale Identification of N-linked Intact Glycopeptides in Human Serum using HILIC Enrichment and Spectral Library Search
Molecular & Cellular Proteomics, 19(4), 672–689.
MeSH headings : Amino Acid Sequence; Biomarkers / blood; Blood Coagulation; Blood Proteins / analysis; Blood Proteins / chemistry; Cell Adhesion Molecules / blood; Cell Lineage; Complement System Proteins / metabolism; Databases, Protein; Glycopeptides / blood; Glycopeptides / chemistry; Glycoproteins / blood; Glycoproteins / chemistry; Glycosylation; Humans; Hydrophobic and Hydrophilic Interactions; Molecular Weight; Peptide Library; Polysaccharides / chemistry; Reference Standards; Reproducibility of Results; Software
TL;DR:
Large-scale identification of N-linked intact glycopeptides by liquid chromatography coupled with tandem mass spectrometry in human serum is challenging because of the wide dynamic range of serum protein abundances, the lack of a complete serum N-glycan database and the existence of proteoforms.
(via Semantic Scholar)
Source: ORCID
Added: May 2, 2023
2019 journal article
Alphabet Projection of Spectra
Journal of Proteome Research.
Contributors: P. Kreitzberg *, M. Bern *, * , F. Yang * & O. Serang*
MeSH headings : Amino Acid Sequence / genetics; Databases, Protein / statistics & numerical data; Glycomics / methods; Mass Spectrometry / methods; Metabolomics / methods; Proteomics / methods; Sequence Analysis, Protein / methods
TL;DR:
A method is proposed that identifies an alphabet of m/z differences that can build large connected graphs from many intense peaks in each spectrum from a collection, and a novel approach is introduced to efficiently find recurring substructures in the de novo graph results.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
4. Quality Education
(OpenAlex)
Source: ORCID
Added: May 2, 2023
2018 journal article
Antigen 85B peptidomic analysis allows species-specific mycobacterial identification
Clinical Proteomics.
Contributors: W. Zhang *, * , Z. Zhao *, J. Fan *, C. Lyon *, A. Zelazny *, Y. Hu *
TL;DR:
Analyzing predicted tryptic peptides of the major mycobacterial antigen Ag85B for their capacity to distinguish Mycobacterium tuberculosis and three NTM species responsible for the majority of pulmonary infections caused by slow-growing myc Cobacteria found one of these species-specific signature peptides in each sample.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
15. Life on Land
(OpenAlex)
Source: ORCID
Added: May 2, 2023
2018 journal article
N-Linked Glycopeptide Identification Based on Open Mass Spectral Library Search
BioMed Research International.
MeSH headings : Glycopeptides / analysis; Glycopeptides / chemistry; Glycosylation; Humans; Proteomics; Reproducibility of Results; Search Engine; Tandem Mass Spectrometry
Source: ORCID
Added: May 2, 2023
2016 journal article
Characterization and relative quantification of phospholipids based on methylation and stable isotopic labeling
Journal of Lipid Research.
MeSH headings : Cell Line, Tumor; Diazomethane / metabolism; Humans; Isotope Labeling; Lysophospholipids / metabolism; Metabolomics / methods; Methylation; Phospholipids / chemistry; Phospholipids / metabolism; Time Factors
TL;DR:
The results showed that phosphate methylation allows fast and sensitive identification of the six major PL classes, including their lysophospholipid counterparts, under positive ionization mode, and the isotopic labeling strategy is capable of providing relative quantitation with adequate accuracy, reproducibility, and a coefficient of variation of 9.1%.
(via Semantic Scholar)
Source: ORCID
Added: May 2, 2023
2016 journal article
Comparative proteomics reveals abnormal binding of ATGL and dysferlin on lipid droplets from pressure overload-induced dysfunctional rat hearts
Scientific Reports.
Contributors: L. Li*, H. Zhang *, W. Wang *, Y. Hong*, J. Wang*, S. Zhang *, S. Xu *, *
MeSH headings : Animals; Heart / physiology; Heart / physiopathology; Lipase / metabolism; Lipid Droplets / metabolism; Mass Spectrometry; Membrane Proteins / chemistry; Membrane Proteins / metabolism; Muscle Proteins / chemistry; Muscle Proteins / metabolism; Myocardium / metabolism; Pressure; Protein Binding; Protein Domains; Protein Interaction Maps; Proteome / metabolism; Proteomics / methods; Rats, Sprague-Dawley; Reproducibility of Results; Subcellular Fractions / metabolism; Triglycerides / metabolism
TL;DR:
This study for the first time reveals the dataset of the heart LD proteome in healthy tissue and the variation of it under cardiac dysfunction, highlighting an association between the altered LD protein localization of dysferlin and ATGL and myocardial dysfunction.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(OpenAlex)
Source: ORCID
Added: May 2, 2023
2016 journal article
Evaluation of Different N-Glycopeptide Enrichment Methods for N-Glycosylation Sites Mapping in Mouse Brain
Journal of Proteome Research.
MeSH headings : Amino Acid Motifs; Animals; Binding Sites; Brain / metabolism; Glycopeptides; Glycosylation; Isotope Labeling; Mass Spectrometry / methods; Mice; Oxygen Isotopes; Sensitivity and Specificity
TL;DR:
This work identified a total of 3446 unique glycosylation sites conforming to the N-X-T/S/C; X ≠ P with (18)O labeling in 1597 N-glycoproteins, and showed the highest sensitivity and specificity of the five enrichment methods evaluated.
(via Semantic Scholar)
Source: ORCID
Added: May 2, 2023
2015 journal article
Profiling and Relative Quantitation of Phosphoinositides by Multiple Precursor Ion Scanning Based on Phosphate Methylation and Isotopic Labeling
Analytical Chemistry.
MeSH headings : Animals; Cattle; Chromatography, Liquid; Diazomethane / chemistry; Humans; Isotope Labeling; Lipids / analysis; Male; Methylation; Phosphates / chemistry; Phosphatidylinositols / analysis; Prostatic Neoplasms / metabolism; Spectrometry, Mass, Secondary Ion / methods
TL;DR:
DAG(+)-specific MPIS and isotopic labeling based MS analysis of phosphoinositides offers unique advantages over existing approaches and presents a powerful tool for research ofosphoinositide metabolism.
(via Semantic Scholar)
Source: ORCID
Added: May 2, 2023
2015 journal article
Proteomic Comparison and MRM-Based Comparative Analysis of Metabolites Reveal Metabolic Shift in Human Prostate Cancer Cell Lines
Journal of Proteome Research.
MeSH headings : AMP-Activated Protein Kinases / metabolism; Acetyl Coenzyme A / metabolism; Adenylate Kinase / metabolism; Cell Line, Tumor; Chromatography, Liquid / methods; Cluster Analysis; Fatty Acids / metabolism; Humans; Isotope Labeling / methods; Male; Mitochondria / metabolism; Models, Biological; Nucleotides / metabolism; Peptides / metabolism; Prostatic Neoplasms / metabolism; Prostatic Neoplasms / pathology; Proteome / classification; Proteome / metabolism; Proteomics / methods; Receptors, Androgen / metabolism; Reproducibility of Results; Signal Transduction; Tandem Mass Spectrometry / methods
TL;DR:
Most of the differentially expressed proteins between each pair function in metabolism, indicating a metabolic shift between AS and AI cells, as validated by multiple reaction monitoring (MRM)-based quantification of nucleotides and relative comparison of fatty acids between these cell lines.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(OpenAlex)
Source: ORCID
Added: May 2, 2023
Employment
Updated: May 1st, 2023 18:14
2023 - present
North Carolina State University Raleigh, North Carolina, US
Research Scholar
METRIC
2019 - 2023
Tulane University New Orleans, Louisiana, US
Postdoc Fellow
Biochemistry and Molecular Biology
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