Ashton Lavoie

Works (5)

Updated: April 23rd, 2025 18:28

2023 article

Identification and characterization of CHO host‐cell proteins in monoclonal antibody bioprocessing

Oh, Y. H., Mendola, K. M., Choe, L. H., Min, L., Lavoie, A. R., Sripada, S. A., … Lenhoff, A. M. (2023, October 25). (T. I. Williams, Ed.). Biotechnology and Bioengineering, Vol. 10, pp. 291–305.

By: Y. Oh*, K. Mendola*, L. Choe*, L. Min*, A. Lavoie n, S. Sripada n, T. Williams n , K. Lee * ...

Contributors: T. Williams n , Y. Oh*, K. Mendola*, L. Choe*, L. Min*, A. Lavoie n, K. Lee *, Y. Yigzaw ...

Ed(s): T. Williams n 

author keywords: bioprocessing; Chinese hamster ovary cells; host-cell proteins; monoclonal antibodies; purification
MeSH headings : Cricetinae; Animals; Humans; Antibodies, Monoclonal / chemistry; Reproducibility of Results; Cricetulus; Mass Spectrometry; CHO Cells
topics (OpenAlex): Viral Infectious Diseases and Gene Expression in Insects; Protein purification and stability; Monoclonal and Polyclonal Antibodies Research
UN Sustainable Development Goals Color Wheel
UN Sustainable Development Goal Categories
3. Good Health and Well-being (Web of Science; OpenAlex)
Sources: Web Of Science, NC State University Libraries, ORCID
Added: November 6, 2023

2020 journal article

Past, Present, and Future of Affinity-based Cell Separation Technologies

Acta Biomaterialia, 112, 29–51.

By: K. Bacon n, A. Lavoie n, B. Rao n , M. Daniele n  & S. Menegatti n 

Contributors: K. Bacon n, A. Lavoie n, B. Rao n , M. Daniele n  & S. Menegatti n 

author keywords: Cell purification; Immunoaffinity; MACS; FACS; Microfluidics
MeSH headings : Cell Separation; Chromatography, Affinity; Flow Cytometry; Ligands; Regenerative Medicine
topics (OpenAlex): Viral Infectious Diseases and Gene Expression in Insects; 3D Printing in Biomedical Research; Microfluidic and Bio-sensing Technologies
TL;DR: This review discusses past and current methods for developing cell-targeting affinity ligands and their application in cell purification, along with the benefits and challenges associated with different purification formats, and presents new technologies towards improving the viability and throughput of cell products for tissue engineering and regenerative medicine. (via Semantic Scholar)
UN Sustainable Development Goals Color Wheel
UN Sustainable Development Goal Categories
9. Industry, Innovation and Infrastructure (OpenAlex)
Sources: Web Of Science, NC State University Libraries, ORCID, Crossref
Added: August 3, 2020

2019 article

Affordable Microfluidic Bead-Sorting Platform for Automated Selection of Porous Particles Functionalized with Bioactive Compounds

Saberi-Bosari, S., Omary, M., Lavoie, A., Prodromou, R., Day, K., Menegatti, S., & San-Miguel, A. (2019, May 10). Scientific Reports, Vol. 9.

By: S. Saberi-Bosari n, M. Omary  n, A. Lavoie n, R. Prodromou n, K. Day n, S. Menegatti n , A. San-Miguel n 

MeSH headings : Combinatorial Chemistry Techniques / instrumentation; Humans; Image Processing, Computer-Assisted; Immunoglobulin G / chemistry; Lab-On-A-Chip Devices; Microfluidic Analytical Techniques / instrumentation; Peptide Library; Porosity; Proof of Concept Study; Unsupervised Machine Learning
topics (OpenAlex): Innovative Microfluidic and Catalytic Techniques Innovation; Monoclonal and Polyclonal Antibodies Research; Advanced Biosensing Techniques and Applications; Microfluidic and Capillary Electrophoresis Applications; Microfluidic and Bio-sensing Technologies
TL;DR: A low-cost microfluidics-based platform enabling automated screening of small porous beads from solid-phase peptide libraries with high sensitivity and specificity, to identify leads with high binding affinity for a biological target is presented. (via Semantic Scholar)
UN Sustainable Development Goals Color Wheel
UN Sustainable Development Goal Categories
Sources: Web Of Science, NC State University Libraries, ORCID
Added: May 28, 2019

2019 article

Discovery and Evaluation of Peptide Ligands for Selective Adsorption and Release of Cas9 Nuclease on Solid Substrates

Day, K., Prodromou, R., Bosari, S. S., Lavoie, A., Omary, M., Market, C., … Menegatti, S. (2019, November 22). Bioconjugate Chemistry, Vol. 30, pp. 3057–3068.

By: K. Day n, R. Prodromou n, S. Bosari n, A. Lavoie n, M. Omary  n, C. Market n, A. Miguel n , S. Menegatti n 

MeSH headings : Adsorption; Amino Acid Sequence; Binding Sites; CRISPR-Associated Protein 9 / isolation & purification; CRISPR-Associated Protein 9 / metabolism; Drug Discovery; Ligands; Molecular Docking Simulation; Peptide Library; Peptides / metabolism; Resins, Synthetic / chemistry; Substrate Specificity
topics (OpenAlex): CRISPR and Genetic Engineering; Advanced biosensing and bioanalysis techniques; RNA Interference and Gene Delivery
TL;DR: This work represents the first effort at developing short synthetic Cas9-binding peptides and demonstrates their applicability as affinity ligands for the purification of a Cas nuclease. (via Semantic Scholar)
UN Sustainable Development Goals Color Wheel
UN Sustainable Development Goal Categories
Sources: Web Of Science, NC State University Libraries, ORCID
Added: January 13, 2020

2019 article

Targeted Capture of Chinese Hamster Ovary Host Cell Proteins: Peptide Ligand Discovery

Lavoie, R. A., Fazio, A., Blackburn, R. K., Goshe, M. B., Carbonell, R. G., & Menegatti, S. (2019, April 8). International Journal of Molecular Sciences, Vol. 20.

By: R. Lavoie n, A. Fazio n, R. Blackburn  n, M. Goshe n, R. Carbonell n & S. Menegatti n 

author keywords: therapeutic antibodies; host cell proteins; protein purification; peptide ligands
MeSH headings : Animals; CHO Cells; Chromatography, Affinity; Chromatography, Liquid; Cricetinae; Cricetulus; Humans; Peptides / chemistry; Peptides / isolation & purification; Proteomics / methods
topics (OpenAlex): Viral Infectious Diseases and Gene Expression in Insects; Protein purification and stability; Monoclonal and Polyclonal Antibodies Research
TL;DR: Development of synthetic peptide ligands capable of capturing a broad spectrum of Chinese hamster ovary (CHO) HCPs with a combination of peptide species that allow for advanced mixed-mode binding is described. (via Semantic Scholar)
UN Sustainable Development Goals Color Wheel
UN Sustainable Development Goal Categories
Sources: Web Of Science, NC State University Libraries
Added: May 6, 2019

Citation Index includes data from a number of different sources. If you have questions about the sources of data in the Citation Index or need a set of data which is free to re-distribute, please contact us.

Certain data included herein are derived from the Web of Science© and InCites© (2026) of Clarivate Analytics. All rights reserved. You may not copy or re-distribute this material in whole or in part without the prior written consent of Clarivate Analytics.