Works (108)
Updated: July 22nd, 2024 08:05
2024 article
Chlorophyllin as a photosensitizer in photodynamic antimicrobial materials
Jiang, C., Scholle, F., Jin, F., Wei, Q., Wang, Q., & Ghiladi, R. A. (2024, February 8). CELLULOSE, Vol. 2.
author keywords: Antimicrobial; Chlorophyllin; Photodynamic inactivation; Photothermal inactivation
doi.org (repository)
Sources: Web Of Science, NC State University Libraries
Added: February 19, 2024
2024 article
Comparison of the Backbone Dynamics of Dehaloperoxidase-Hemoglobin Isoenzymes
Gonzalez-Delgado, J. M., Thompson, P. M., Andralojc, W., Gdaniec, Z., Ghiladi, R. A., & Franzen, S. (2024, April 2). JOURNAL OF PHYSICAL CHEMISTRY B, Vol. 4.
Sources: Web Of Science, NC State University Libraries
Added: April 15, 2024
2024 journal article
Enhanced Antioxidant Extraction from <i>Lonicerae japonicae Flos</i> Based on a Novel Optimization Strategy with Tailored Deep Eutectic Solvents
SEPARATIONS, 11(6).
author keywords: deep eutectic solvents; extraction of antioxidants; Lonicerae japonicae Flos; sample pretreatment; quality evaluation
Sources: ORCID, Web Of Science, NC State University Libraries
Added: June 22, 2024
2024 journal article
HemN2 Regulates the Virulence of <i>Pseudomonas donghuensis</i> HYS through 7-Hydroxytropolone Synthesis and Oxidative Stress
BIOLOGY-BASEL, 13(6).
author keywords: Pseudomonas donghuensis HYS; HemN2; 7-hydroxytropolone; GacS; oxidative stress
Sources: ORCID, Web Of Science, NC State University Libraries
Added: June 1, 2024
2024 journal article
Neuropeptides affecting social behavior in mammals: Oxytocin
PEPTIDES, 177.
author keywords: Oxytocin; Parental behavior; Anxiety; Aggressive behavior; Attachment; Empathy
UN Sustainable Development Goal Categories
10. Reduced Inequalities
(OpenAlex)
Sources: Web Of Science, NC State University Libraries
Added: June 11, 2024
2024 journal article
Serum binding folate receptor autoantibodies lower in autistic boys and positively-correlated with folate
BIOMEDICINE & PHARMACOTHERAPY, 172.
author keywords: Autism; Folate receptor autoantibody; Folate; Ferritin; VB12
TL;DR:
Differences revealed that the low serum FRAA in autistic children was mediated by multiple factors, which deserves more comprehensive investigation with larger population and mechanistic studies.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
2. Zero Hunger
(OpenAlex)
Sources: Web Of Science, NC State University Libraries
Added: March 25, 2024
2023 article
Celebrating Kenneth D. Karlin for his ACS Award for Distinguished Service in the Advancement of Inorganic Chemistry
Lucas, H. R., Kim, E., & Ghiladi, R. A. (2023, April). JOURNAL OF INORGANIC BIOCHEMISTRY, Vol. 241.
MeSH headings : History, 20th Century; History, 21st Century; Awards and Prizes; Chemistry, Inorganic
Sources: Web Of Science, NC State University Libraries
Added: May 1, 2023
2023 journal article
Comparative study of the binding and activation of 2,4-dichlorophenol by dehaloperoxidase A and B
JOURNAL OF INORGANIC BIOCHEMISTRY, 247.
author keywords: Peroxidase; 4-dichlorophenol; electron transfer; Activation energy; Enzyme kinetics; Solvent effect
TL;DR:
Comparison of the binding and reactivity of the substrate 2,4-dichlorophenol (DCP) in the isoforms DHPA and B contributes to the studies of DHP as a naturally occurring bioremediation enzyme capable of oxidizing a wide range of environmental pollutants.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, NC State University Libraries
Added: August 28, 2023
2023 article
Hydrothermally Derived Green Carbon Dots from Broccoli Water Extracts: Decreased Toxicity, Enhanced Free-Radical Scavenging, and Anti-Inflammatory Performance
Deng, W.-wen, Zang, C.-ru, Li, Q.-chen, Sun, B., Mei, X.-ping, Bai, L., … Wang, J. (2023, February 6). ACS BIOMATERIALS SCIENCE & ENGINEERING, Vol. 2.
author keywords: biomass carbon dot; free-radical scavenging; broccoli; anti-inflammation; antioxidant
MeSH headings : Animals; Antioxidants; Brassica; Zebrafish; Carbon / chemistry; Water; Anti-Inflammatory Agents / chemistry; Solvents
TL;DR:
This work indicates that the antioxidant activity of CDs could be enhanced by using solvent extracts of biomass as precursors, and the obtained BWE-CDs exhibit characteristics of greenness, low toxicity, and excellent antioxidant and anti-inflammatory activities, which suggests the potential promising application of BWE -CDs as an antioxidant nanomedicine for inflammatory therapy.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, NC State University Libraries
Added: March 13, 2023
2023 article
Journal of Inorganic Biochemistry - Karlin Special Issue
Lucas, H. R., Kim, E., & Ghiladi, R. A. (2023, April). JOURNAL OF INORGANIC BIOCHEMISTRY, Vol. 241.
Sources: Web Of Science, NC State University Libraries
Added: April 24, 2023
2023 journal article
Oxidation of bisphenol A (BPA) and related compounds by the multifunctional catalytic globin dehaloperoxidase
JOURNAL OF INORGANIC BIOCHEMISTRY, 238.
author keywords: Bisphenols; Biphenols; Dehaloperoxidase; Hemoglobin; Biodegradation; Peroxidase
MeSH headings : Hemoglobins / chemistry; Oxidoreductases; Peroxidases / metabolism; Phenols; Polychaeta / enzymology
TL;DR:
The data presented here strongly suggest that DHP B can catalyze the oxidation of bisphenols and biphenols, thus providing evidence of how infaunal invertebrates can contribute to the biotransformation of these marine pollutants.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
14. Life Below Water
(OpenAlex)
Sources: Web Of Science, NC State University Libraries
Added: January 9, 2023
2023 journal article
Preventing the spread of life-threatening gastrointestinal microbes on the surface of a continuously self-disinfecting block polymer
JOURNAL OF COLLOID AND INTERFACE SCIENCE, 652, 718–726.
author keywords: Anionic block polymer; Clostridioides difficile; Candida auris; Candida albicans; Antimicrobial; Self-disinfecting; Broad-spectrum; Infection prevention
TL;DR:
It is demonstrated that highly persistent, drug-resistant and transmissible healthcare pathogens such as Clostridioides difficile and Candida auris can be rapidly inactivated on the solid surface of a self-disinfecting anionic block polymer that inherently generates a water surface layer that is highly acidic (pH < 1) upon hydration.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, NC State University Libraries
Added: September 25, 2023
2023 journal article
The role of sound stimulation in production of plant secondary metabolites
NATURAL PRODUCTS AND BIOPROSPECTING, 13(1).
author keywords: Sound; Music; Plant secondary metabolites; Flavonoid; Antioxidant; Immunity
TL;DR:
The potential role of sound stimulation on the biosynthesis of secondary metabolites and the followed cascade of physiological changes in plants is examined, from the perspective of transcriptional regulation and epigenetic regulation for the first time.
(via Semantic Scholar)
Sources: Web Of Science, NC State University Libraries
Added: December 11, 2023
2022 journal article
Bridging the functional gap between reactivity and inhibition in dehaloperoxidase B from Amphitrite ornata: Mechanistic and structural studies with 2,4-and 2,6-dihalophenols
JOURNAL OF INORGANIC BIOCHEMISTRY, 236.
author keywords: Catalytic globin; Dihalophenol; Heme; Oxidation; Peroxidase; Peroxygenase
MeSH headings : Animals; Halogens; Hemoglobins / chemistry; Hydrogen Peroxide / chemistry; Peroxidases / metabolism; Polychaeta
TL;DR:
The findings here on dihalophenol reactivity with DHP advance the understanding of how these compounds bridge the inhibitory and oxidative functions of their mono- and trihalophenols counterparts, respectively, and provide further insight into the protein structure-function paradigm relevant to multifunctional catalytic globins in comparison to their monofunctional analogs.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
14. Life Below Water
(OpenAlex)
Sources: Web Of Science, NC State University Libraries
Added: October 24, 2022
2022 journal article
Complementarity of neutron, XFEL and synchrotron crystallography for defining the structures of metalloenzymes at room temperature
IUCRJ, 9, 610–624.
author keywords: serial femtosecond crystallography; serial synchrotron crystallography; neutron crystallography; XFELs; room temperature; metalloenzymes
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
16. Peace, Justice and Strong Institutions
(OpenAlex)
Sources: Web Of Science, NC State University Libraries
Added: September 29, 2022
2022 journal article
Dual-functionalized luminescent/photodynamic composite fabrics: Synergistic antibacterial activity for self-disinfecting textiles
APPLIED SURFACE SCIENCE, 587.
author keywords: Antibacterial; Coating; Luminescence; Photodynamic; Photosensitizer; Singlet oxygen
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, NC State University Libraries
Added: April 25, 2022
2022 journal article
Electrospinning membranes with Au@carbon dots: Low toxicity and efficient antibacterial photothermal therapy
BIOMATERIALS ADVANCES, 142.
author keywords: Antibacterial; Carbon dots; Gold nanoparticles; Photothermal; Wound dressings
MeSH headings : Male; Mice; Animals; Gold / pharmacology; Staphylococcus aureus; Metal Nanoparticles / therapeutic use; Photothermal Therapy; Escherichia coli; Carbon / pharmacology; Anti-Bacterial Agents / pharmacology
TL;DR:
NIR-irradiated Au@CD-based membranes and related materials are promising photothermal antimicrobial platforms for wound dressings and related healthcare applications and are confirmed as a safe and potentially efficient strategy to combat bacterial infections.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, NC State University Libraries
Added: November 14, 2022
2022 journal article
In situ grown bacterial cellulose/MoS2 composites for multi-contaminant wastewater treatment and bacteria inactivation
CARBOHYDRATE POLYMERS, 277.
author keywords: Antibacterial; Bacterial cellulose; Molybdenum disulfide(MoS2); Peroxidase-like catalytic activity; Photocatalytic; Photothermal
MeSH headings : Anti-Bacterial Agents / chemistry; Anti-Bacterial Agents / pharmacology; Cellulose / chemistry; Cellulose / pharmacology; Disulfides / chemistry; Disulfides / pharmacology; Escherichia coli / drug effects; Microbial Sensitivity Tests; Molybdenum / chemistry; Molybdenum / pharmacology; Staphylococcus aureus / drug effects; Wastewater / microbiology; Water Purification
Sources: Web Of Science, NC State University Libraries
Added: November 29, 2021
2022 journal article
Mossbauer studies of the ferryl, ferrous and ferric states of dehaloperoxidase from A. ornata
JOURNAL OF INORGANIC BIOCHEMISTRY, 234.
author keywords: Mossbauer spectroscopy; Peroxidase; Heme enzyme; Ferryl; Globin
MeSH headings : Animals; Ferric Compounds / chemistry; Heme / chemistry; Hemoglobins / chemistry; Hydrogen Peroxide / chemistry; Iron / chemistry; Myoglobin / chemistry; Peroxidases / metabolism; Polychaeta; Spectroscopy, Mossbauer
TL;DR:
The isomer shift and quadrupole splitting of DHP in the four states studied are expectedly similar to both peroxidases and to myoglobin, and differences in electronic structure between DHP and other heme proteins and enzyme are observed in the high-field Mössbauer spectra of the ferric state, which show pH-dependent zero-field splittings suggesting a heme site in which the ligand field strength at the iron ion is tuned by pH.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
14. Life Below Water
(OpenAlex)
Sources: Web Of Science, NC State University Libraries
Added: December 12, 2022
2021 journal article
A new inhibition mechanism in the multifunctional catalytic hemoglobin dehaloperoxidase as revealed by the DHP A(V59W) mutant: A spectroscopic and crystallographic study
JOURNAL OF PORPHYRINS AND PHTHALOCYANINES, 25(7-8), 756–771.
author keywords: Peroxidase; hemoglobin; structure-function; tryptophan; inhibition
TL;DR:
The data reveal a new mechanism of DHP inhibition, namely a shift towards a non-reactive form by OH that is strongly stabilized (presumably through H-bonding interactions) by the presence of W59 in the distal cavity.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, NC State University Libraries
Added: August 23, 2021
2021 review
Dehaloperoxidase: An enzymatic Swiss army knife
[Review of ]. COORDINATION CHEMISTRY REVIEWS, 441.
author keywords: Dehaloperoxidase; Peroxygenase enzymes; Hydrogen peroxide dependent oxidation; Structure-function relationship
TL;DR:
This review aims to provide further structural and mechanistic details into the other three activities performed by dehaloperoxidase, with a particular emphasis on its peroxygenase activity.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
14. Life Below Water
(OpenAlex)
Sources: Web Of Science, NC State University Libraries
Added: June 10, 2021
2021 journal article
Porous protoporphyrin IX-embedded cellulose diacetate electrospun microfibers in antimicrobial photodynamic inactivation
Materials Science and Engineering: C, 118, 111502.
author keywords: Antibacterial; Photodynamic inactivation; Cellulose diacetate; Electrospinning; Microfiber; Porous; Potassium iodide; Protoporphyrin IX
MeSH headings : Anti-Bacterial Agents / pharmacology; Cellulose / analogs & derivatives; Escherichia coli; Photochemotherapy; Photosensitizing Agents / pharmacology; Photosensitizing Agents / therapeutic use; Porosity; Protoporphyrins; Staphylococcus aureus
TL;DR:
The findings indicate that the electrospun CA microfibrous membrane is an ideal matrix for a photosensitizer such as PpIX to be embedded and effectively sensitized upon visible light illumination, and its antimicrobial photodynamic inactivation efficiency could be strongly enhanced with the increased KI addition, showing a promising future for its use in pathogen transmission defensive materials.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Crossref, NC State University Libraries
Added: December 22, 2020
2021 journal article
Rapid and Repetitive Inactivation of SARS-CoV-2 and Human Coronavirus on Self-Disinfecting Anionic Polymers
ADVANCED SCIENCE, 8(11).
author keywords: antiviral materials; charged block polymers; microphase‐ ordered materials; polyanions; thermoplastic elastomers
MeSH headings : COVID-19 / prevention & control; COVID-19 / transmission; COVID-19 / virology; Disinfectants / therapeutic use; Humans; Pandemics; Polymers / chemistry; Polymers / therapeutic use; SARS-CoV-2 / drug effects; SARS-CoV-2 / pathogenicity
TL;DR:
It is demonstrated that an architecturally‐ and chemically‐diverse family of nanostructured anionic polymers yield a rapid and continuous disinfecting alternative to inactivate coronaviruses and prevent their transmission from contact with contaminated surfaces.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
Sources: Web Of Science, NC State University Libraries
Added: April 5, 2021
2021 journal article
Serum nitrite and nitrate: A potential biomarker for post-covid-19 complications
FREE RADICAL BIOLOGY AND MEDICINE, 175, 216–225.
author keywords: COVID-19; Nitric oxide; Nitrite; Nitrate; Biomarker; Long-term effect
MeSH headings : Adult; Aged; Biomarkers; COVID-19; Humans; Nitrates; Nitric Oxide; Nitrites; SARS-CoV-2
TL;DR:
It is suggested that NO metabolites might serve as a predictor to track the health status of recovered COVID-19 patients, highlighting the need to elucidate the role of NO after SARS-CoV-2 infection.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, NC State University Libraries
Added: October 12, 2021
2021 journal article
Synergistic Photodynamic and Photothermal Antibacterial Activity of In Situ Grown Bacterial Cellulose/MoS2-Chitosan Nanocomposite Materials with Visible Light Illumination
ACS APPLIED MATERIALS & INTERFACES, 13(26), 31193–31205.
author keywords: antibacterial; bacterial cellulose; chitosan; molybdenum disulfide; photodynamic; photothermal
MeSH headings : Animals; Anti-Bacterial Agents / chemistry; Anti-Bacterial Agents / pharmacology; Anti-Bacterial Agents / radiation effects; Anti-Bacterial Agents / toxicity; Cell Line; Cellulose / chemistry; Cellulose / toxicity; Chitosan / chemistry; Chitosan / toxicity; Disulfides / chemistry; Disulfides / pharmacology; Disulfides / radiation effects; Disulfides / toxicity; Escherichia coli / drug effects; Heating; Light; Membranes, Artificial; Mice; Microbial Sensitivity Tests; Molybdenum / chemistry; Molybdenum / pharmacology; Molybdenum / radiation effects; Molybdenum / toxicity; Nanocomposites / chemistry; Nanocomposites / radiation effects; Nanocomposites / toxicity; Photosensitizing Agents / chemistry; Photosensitizing Agents / pharmacology; Photosensitizing Agents / radiation effects; Photosensitizing Agents / toxicity; Reactive Oxygen Species / metabolism; Staphylococcus aureus / drug effects
TL;DR:
In situ grown bacterial cellulose/MoS2-chitosan nanocomposite materials that utilize synergistic membrane disruption and photodynamic and photothermal antibacterial activities to achieve more efficient bactericidal activity are developed.
(via Semantic Scholar)
Sources: Web Of Science, NC State University Libraries
Added: July 26, 2021
2021 journal article
The role of NO in COVID-19 and potential therapeutic strategies
Free Radical Biology and Medicine, 163, 153–162.
author keywords: COVID-19; Nitric oxide; Vasodilation; Anti-viral; Anti-inflammation
MeSH headings : Administration, Inhalation; Anti-Inflammatory Agents / blood; Anti-Inflammatory Agents / therapeutic use; Anticoagulants / blood; Anticoagulants / therapeutic use; Antiviral Agents / blood; Antiviral Agents / therapeutic use; COVID-19 / blood; COVID-19 / pathology; COVID-19 / virology; Endothelial Cells / drug effects; Endothelial Cells / pathology; Endothelial Cells / virology; Humans; Inflammation; Lung / blood supply; Lung / drug effects; Lung / virology; Mitochondria / drug effects; Mitochondria / virology; Nitric Oxide / blood; Nitric Oxide / therapeutic use; SARS-CoV-2 / drug effects; SARS-CoV-2 / pathogenicity; Severity of Illness Index; Vasodilation / drug effects; COVID-19 Drug Treatment
TL;DR:
The potential role of NO during SARS-CoV-2 infection is examined from the perspective of the unique physical, chemical and biological properties and potential mechanisms of NO in COVID-19, as well as possible therapeutic strategies using inhaled NO.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
Sources: Crossref, NC State University Libraries, Web Of Science
Added: February 6, 2021
2021 review
The structural appeal of metal-organic frameworks in antimicrobial applications
[Review of ]. COORDINATION CHEMISTRY REVIEWS, 442.
author keywords: Metal-organic frameworks; MOF-based composites; Structural property; Antimicrobial mechanism; Antimicrobial applications
TL;DR:
The structural characteristics of MOFs that are demonstrated to be the main structural determinants in microorganism inactivation are discussed, with a particular focus on the type(s) of metal clusters, organic ligands, nanoparticles, and pores employed.
(via Semantic Scholar)
Sources: Web Of Science, NC State University Libraries
Added: July 12, 2021
2021 journal article
Toward Universal Photodynamic Coatings for Infection Control
FRONTIERS IN MEDICINE, 8.
author keywords: antimicrobial; Coronavirus; coatings; photodynamic inactivation; photosensitizer; polymer; singlet oxygen; Staphylococcus aureus
TL;DR:
The antimicrobial efficacy of a simple bicomponent spray coating composed of the commercially-available UV-photocrosslinkable polymer N-methyl-4(4'-formyl-styryl)pyridinium methosulfate acetal poly(vinyl alcohol) (SbQ-PVA) and one of three aPDI photosensitizers (PSs) is evaluated.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
Sources: Web Of Science, NC State University Libraries
Added: August 23, 2021
2020 journal article
Carbon quantum dots: A bright future as photosensitizers for in vitro antibacterial photodynamic inactivation
Journal of Photochemistry and Photobiology B: Biology, 206, 111864.
author keywords: Antibacterial; Carbon quantum dots; Escherichia coli; Photodynamic inactivation; Staphylococcus aureus
TL;DR:
It is demonstrated that CQDs can be facilely prepared, operate via a Type II mechanism, and are effective photosensitizers for in vitro antibacterial photodynamic inactivation (aPDI).
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, Crossref, NC State University Libraries
Added: April 27, 2020
2020 journal article
Color-Variable Photodynamic Antimicrobial Wool/Acrylic Blended Fabrics
Materials, 13(18), 4141.
author keywords: antibacterial; photodynamic; apparent color; blended fabric; photosensitizer; rose bengal; cationic dyes; wool; acrylic
TL;DR:
Overall, the findings demonstrate the feasibility and potential applications of low cost and color variable RB-loaded W/A blended fabrics as effective self-disinfecting textiles against pathogen transmission.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, ORCID, Crossref, NC State University Libraries
Added: November 9, 2020
2020 journal article
One-pot method based on deep eutectic solvent for extraction and conversion of polydatin to resveratrol from Polygonum cuspidatum
Food Chemistry, 343, 128498.
author keywords: Resveratrol; Extraction and conversation of polydatin; Polygonum cuspidatum; Deep eutectic solvents
MeSH headings : Chemical Fractionation / methods; Fallopia japonica / chemistry; Glucosides / chemistry; Glucosides / isolation & purification; Hydrolysis; Resveratrol / chemistry; Solvents / chemistry; Stilbenes / chemistry; Stilbenes / isolation & purification
TL;DR:
A novel one-pot method based on deep eutectic solvent (DES) was developed for simultaneous extraction and conversion of polydatin to resveratrol from Polygonum cuspidatum for the first time and indicated that one green method was successfully established.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, Crossref, NC State University Libraries
Added: December 22, 2020
2020 journal article
Photodynamic Coatings on Polymer Microfibers for Pathogen Inactivation: Effects of Application Method and Composition
ACS Applied Materials & Interfaces, 13(1), 155–163.
author keywords: hospital-acquired infections; photodynamic coatings; porphyrin photosensitizer; SARS-CoV-2 virus; polymer microfibers
MeSH headings : COVID-19 / prevention & control; COVID-19 / virology; Escherichia coli / drug effects; Escherichia coli / pathogenicity; Humans; Iatrogenic Disease / prevention & control; Light; Methicillin-Resistant Staphylococcus aureus / drug effects; Methicillin-Resistant Staphylococcus aureus / pathogenicity; Microfibrils / chemistry; Pandemics; Photosensitizing Agents / chemistry; Photosensitizing Agents / pharmacology; Polymers / chemistry; Polymers / pharmacology; Porphyrins / chemistry; Porphyrins / pharmacology; SARS-CoV-2 / drug effects; SARS-CoV-2 / pathogenicity; Singlet Oxygen
TL;DR:
These coated fibers can inactivate a human common cold coronavirus serving as a surrogate for the SARS-CoV-2 virus and are confirmed to be able to inactivate antibiotic-resistant bacteria.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, Crossref, NC State University Libraries
Added: January 31, 2021
2020 journal article
Photoinactivation of bacteria by hypocrellin-grafted bacterial cellulose
Cellulose, 27(2), 991–1007.
author keywords: Antibacterial photodynamic inactivation; Bacterial cellulose; Escherichia coli; Hypocrellin; Potassium iodide; Staphylococcus aureus
TL;DR:
The findings demonstrated that hypocrellin-grafted bacterial cellulose is a sustainable material from which potent photodynamic antibacterial materials may be derived, and was characterized by both physical and spectroscopic methods.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, Crossref, NC State University Libraries
Added: December 2, 2019
2019 journal article
A facile strategy for photoactive nanocellulose-based antimicrobial materials
Green Chemistry, 21(12), 3424–3435.
TL;DR:
Anti-infective materials based upon renewable nanocellulose–porphyrin conjugates photodynamically inactivated four strains of drug-resistant bacteria and two viruses by 99.999+%.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, NC State University Libraries, Crossref, ORCID
Added: July 8, 2019
2019 magazine article
Antimicrobial Thermoplastic Elastomers: Strategic Pathways for the Future of Broad-Spectrum Anti-Infective Materials
Peddinti, B., Scholle, F., Ghiladi, R. A., & Spontak, R. (2019, October). Rubber World, 261(1), 67–77.
Source: NC State University Libraries
Added: December 8, 2020
2019 journal article
BODIPY-embedded electrospun materials in antimicrobial photodynamic inactivation
Photochemical & Photobiological Sciences, 18(8), 1923–1932.
Contributors: n , X. Zhang n , J. Zhu n, F. Scholle n & K. Stoll n
MeSH headings : Acinetobacter baumannii / drug effects; Acrylic Resins / chemistry; Acrylic Resins / pharmacology; Anti-Bacterial Agents / chemistry; Anti-Bacterial Agents / pharmacology; Boron Compounds / chemistry; Boron Compounds / pharmacology; Klebsiella pneumoniae / drug effects; Methicillin-Resistant Staphylococcus aureus / drug effects; Microbial Sensitivity Tests; Nanofibers / chemistry; Nylons / chemistry; Nylons / pharmacology; Particle Size; Photochemotherapy; Photosensitizing Agents / chemistry; Photosensitizing Agents / pharmacology; Vancomycin-Resistant Enterococci / drug effects
TL;DR:
The results demonstrate the potential for electrospun BODIPY ^(+)-embedded nanofiber materials as the basis for pathogen-specific anti-infective materials, even at low photosensitizer loadings.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, ORCID, NC State University Libraries, Crossref
Added: September 16, 2019
2019 journal article
High-throughput structures of protein–ligand complexes at room temperature using serial femtosecond crystallography
IUCrJ, 6(6), 1074–1085.
author keywords: serial femtosecond crystallography; ligand binding; high throughput; X-ray crystallography; damage-free structures; X-ray free-electron lasers
TL;DR:
Here, an efficient solution using high-throughput, fixed-target serial femtosecond crystallography at an XFEL is demonstrated.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, NC State University Libraries, Crossref
Added: November 25, 2019
2019 journal article
Inherently self-sterilizing charged multiblock polymers that kill drug-resistant microbes in minutes
Materials Horizons, 6(10), 2056–2062.
TL;DR:
It is demonstrated that midblock-sulfonated block polymers can kill 99.9999% of “superbugs,” including bacteria and viruses, in just 5 minutes due to an abrupt pH reduction.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, NC State University Libraries, Crossref
Added: December 16, 2019
2019 journal article
Let There Be Light: Targeted Photodynamic Therapy Using High Aspect Ratio Plant Viral Nanoparticles
Macromolecular Bioscience, 19(5), 1800407.
author keywords: cancer phototherapy; nucleolin targeting; tobacco green mosaic virus; tobacco mosaic virus; zinc photosensitizer
MeSH headings : Animals; Cell Line, Tumor; Drug Carriers / chemistry; Drug Carriers / pharmacology; Melanoma, Experimental / drug therapy; Melanoma, Experimental / metabolism; Melanoma, Experimental / pathology; Metalloporphyrins / chemistry; Metalloporphyrins / pharmacology; Mice; Nanoparticles / chemistry; Nanoparticles / therapeutic use; Photochemotherapy; Tobacco Mosaic Virus / chemistry
TL;DR:
This is the first study investigating tobacco mosaic virus for medical applications and a fivefold increase in cancer cell killing is observed using nucleolin-targeted TMV loaded with tricationic Zn-Por and displaying the nucleolini-specific F3 peptide.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
Sources: Web Of Science, ORCID, NC State University Libraries, Crossref
Added: July 1, 2019
2019 conference paper
Mn-doped Zn/S quantum dots as photosensitizers for antimicrobial photodynamic inactivation
In T. Dai, M. X. Wu, & J. Popp (Eds.), Photonic Diagnosis and Treatment of Infections and Inflammatory Diseases II.
Ed(s): T. Dai, M. Wu & J. Popp
Event: Photonic Diagnosis, Monitoring, Prevention, and Treatment of Infections and Inflammatory Diseases 2019
TL;DR:
The utility of Mn:ZnS QDs as photosensitizers for aPDI is demonstrated, together with antiviral studies of Zika virus that showed ~3 log units of inactivation, to demonstrate the power of these findings.
(via Semantic Scholar)
Sources: Crossref, NC State University Libraries
Added: August 28, 2020
2019 journal article
The multifunctional globin dehaloperoxidase strikes again: Simultaneous peroxidase and peroxygenase mechanisms in the oxidation of EPA pollutants
Archives of Biochemistry and Biophysics, 673, 108079.
author keywords: Cresols; Dehaloperoxidase; Hemoglobin; Oxidation; Peroxidase; Peroxygenase
MeSH headings : Biocatalysis; Environmental Pollutants / metabolism; Globins / metabolism; Mixed Function Oxygenases / chemistry; Mixed Function Oxygenases / metabolism; Models, Molecular; Peroxidase / chemistry; Peroxidase / metabolism; Protein Conformation; United States; United States Environmental Protection Agency
TL;DR:
The findings establish cresols as a new class of substrate for DHP, demonstrate that multiple oxidation mechanisms may exist for a given substrate, and provide further evidence that different substituents can serve as functional switches between the different activities performed by dehaloperoxidase.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Crossref, NC State University Libraries
Added: August 28, 2020
2019 journal article
Towards microbe-targeted photosensitizers: Synthesis, characterization and in vitro photodynamic inactivation of the tuberculosis model pathogen M. smegmatis by porphyrin-peptide conjugates
Journal of Porphyrins and Phthalocyanines, 23(11n12), 1414–1439.
author keywords: antimicrobial; Mycobacterium smegmatis; peptide; photodynamic inactivation; porphyrin; tuberculosis
TL;DR:
The ability of PPCs to maintain their antimicrobial photodynamic inactivation efficacy when possessing a short cationic peptides for enabling the potential targeting of pathogens in vivo is demonstrated.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
Sources: Web Of Science, NC State University Libraries, Crossref
Added: February 10, 2020
2019 journal article
Wool/Acrylic Blended Fabrics as Next-Generation Photodynamic Antimicrobial Materials
ACS Applied Materials & Interfaces, 11(33), 29557–29568.
author keywords: acrylic; antibacterial; blended fabric; photodynamic inactivation; photosensitizer; Rose Bengal; wool
MeSH headings : Animals; Anti-Bacterial Agents / chemistry; Photosensitizing Agents / chemistry; Wool Fiber
TL;DR:
The results suggest the feasibility of photosensitizer-embedded blended fabrics produced through a one-step dyeing process as a low-cost and scalable method for creating effective self-disinfecting textiles for infection prevention, and whose inclusion of a second traditional dye for color variation will further benefit their adoption from a commercial standpoint.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Crossref, NC State University Libraries, Web Of Science
Added: April 20, 2020
2018 journal article
How nature tunes isoenzyme activity in the multifunctional catalytic globin dehaloperoxidase from Amphitrite ornata
Biochimica Et Biophysica Acta (BBA) - Proteins and Proteomics, 1866(2), 230–241.
author keywords: Globin; Isoenzyme; Peroxidase; Peroxygenase; Structure-function
MeSH headings : Amino Acid Substitution; Animals; Crystallography, X-Ray; Hemoglobins / chemistry; Hemoglobins / genetics; Hemoglobins / metabolism; Isoenzymes / chemistry; Isoenzymes / genetics; Isoenzymes / metabolism; Mutation, Missense; Peroxidase / chemistry; Peroxidase / genetics; Peroxidase / metabolism; Polychaeta / enzymology; Polychaeta / genetics; Protein Domains
TL;DR:
Light is shed on the structure-function relationship in dehaloperoxidase, and the foundation for understanding how enzymatic activity can be tuned in isoenzymes of a multifunctional catalytic globin is established.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, ORCID, NC State University Libraries, Crossref
Added: August 6, 2018
2018 journal article
Peroxidase versus Peroxygenase Activity: Substrate Substituent Effects as Modulators of Enzyme Function in the Multifunctional Catalytic Globin Dehaloperoxidase
Biochemistry, 57(30), 4455–4468.
MeSH headings : Animals; Crystallography, X-Ray; Guaiacol / analogs & derivatives; Guaiacol / metabolism; Halogenation; Hemoglobins / chemistry; Hemoglobins / metabolism; Hydrogen Peroxide / metabolism; Models, Molecular; Oxidation-Reduction; Peroxidases / chemistry; Peroxidases / metabolism; Polychaeta / chemistry; Polychaeta / enzymology; Polychaeta / metabolism; Substrate Specificity
TL;DR:
Results presented here show that simple substituent effects can serve as functional switches between peroxidase and peroxygenase activities in this multifunctional catalytic globin, demonstrating the breadth of heterocyclic compounds of anthropogenic origin that can potentially disrupt marine hemoglobins or function as environmental stressors.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
14. Life Below Water
(OpenAlex)
Sources: Crossref, ORCID, NC State University Libraries
Added: February 24, 2020
2018 journal article
Photodynamic Polymers as Comprehensive Anti-Infective Materials: Staying Ahead of a Growing Global Threat
ACS Applied Materials & Interfaces, 10(31), 25955–25959.
author keywords: antimicrobial photodynamic inactivation; antibacterial surface; anti-infective polymer; antibiotic-resistant bacteria; antiviral; block copolymer; olefin thermoplastic elastomer
MeSH headings : Anti-Infective Agents / chemistry; Light; Photosensitizing Agents; Polymers; Singlet Oxygen
TL;DR:
The anti-infective efficacy of bulk thermoplastic elastomer films containing zinc-tetra(4- N-methylpyridyl)porphine (ZnTMPyP4+), a photoactive antimicrobial that utilizes visible light to generate singlet oxygen, is explored.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Crossref, ORCID, NC State University Libraries
Added: February 5, 2020
2018 journal article
Photooxidation Properties of Photosensitizer/Direct Dye Patterned Polyester/Cotton Fabrics
Fibers and Polymers, 19(8), 1687–1693.
author keywords: Cationic dyeable polyester; Polyester/cotton knitted fabric; Dyeing process; Antimicrobial; Photooxidation
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Crossref, NC State University Libraries
Added: February 24, 2020
2018 journal article
Preparation of photodynamic P(MMA-co-MAA) composite nanofibers doped with MMT: A facile method for increasing antimicrobial efficiency
Applied Surface Science, 457, 247–255.
author keywords: Montmorillonite; Photodynamic; Nanofiber; Electrospinning; Photosensitizer; Antibacterial
TL;DR:
The results demonstrate that MMT and similar additives may be a universal method for increasing the adsorption capacity of cationic photosensitizers in electrospun nanofibers, thereby generating materials with improved photodynamic inactivation efficacy without significantly changing the fiber morphology, cost, or ease of production.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Crossref, NC State University Libraries
Added: February 24, 2020
2018 journal article
Protoporphyrin IX conjugated bacterial cellulose via diamide spacer arms with specific antibacterial photodynamic inactivation against Escherichia coli
Cellulose, 25(3), 1673–1686.
author keywords: Protoporphyrin IX; Bacterial cellulose; aPDI; Specific antibacterial effect; Escherichia coli
TL;DR:
Though the reusability of the as-fabricated materials needs to be further enhanced, this work provides a potent strategy for efficient photodynamic inactivation against Gram negative bacteria using neutral photosensitizers.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, NC State University Libraries, Crossref
Added: August 6, 2018
2018 journal article
Protoporphyrin-IX conjugated cellulose nanofibers that exhibit high antibacterial photodynamic inactivation efficacy
Nanotechnology, 29(26), 265601.
author keywords: cellulose; antibacterial; photodynamic; photosensitizer; E. coli; S. aureus
MeSH headings : Anti-Bacterial Agents / pharmacology; Calorimetry, Differential Scanning; Cellulose / chemistry; Escherichia coli / drug effects; Escherichia coli / ultrastructure; Microbial Sensitivity Tests; Microbial Viability / drug effects; Nanofibers / chemistry; Nanofibers / ultrastructure; Photochemotherapy; Protoporphyrins / pharmacology; Reactive Oxygen Species / metabolism; Spectrometry, Fluorescence; Spectrophotometry, Ultraviolet; Spectroscopy, Fourier Transform Infrared; Spectrum Analysis, Raman; Staphylococcus aureus / drug effects; Staphylococcus aureus / ultrastructure; Stress, Mechanical; Thermogravimetry
TL;DR:
The conjugation strategy employed here provides a scalable, facile and efficient route to creating nanofibrous materials from natural polymers with a high photosensitizer loading, enabling the use of commercially-available neutral porphyrin photosensiters, such as PPIX, in the design and synthesis of potent anti-infective nanomaterials.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
6. Clean Water and Sanitation
(OpenAlex)
Sources: ORCID, Crossref, NC State University Libraries
Added: December 15, 2020
2018 journal article
Protoporphyrin-IX conjugated cellulose nanofibers that exhibit high antibacterial photodynamic inactivation efficacy
Nanotechnology, 29(26).
Source: NC State University Libraries
Added: August 6, 2018
2018 journal article
Selective tuning of activity in a multifunctional enzyme as revealed in the F21W mutant of dehaloperoxidase B from Amphitrite ornata
JBIC Journal of Biological Inorganic Chemistry, 23(2), 209–219.
author keywords: Globin; Peroxidase; Peroxygenase; Structure-function relationship
MeSH headings : Animals; Catalysis; Crystallography, X-Ray; Hemoglobins / chemistry; Hemoglobins / genetics; Hemoglobins / isolation & purification; Hemoglobins / metabolism; Mutation; Peroxidases / chemistry; Peroxidases / genetics; Peroxidases / isolation & purification; Peroxidases / metabolism; Polychaeta / enzymology; Spectrophotometry, Ultraviolet; Substrate Specificity
TL;DR:
Stopped-flow UV/visible studies and isotope labeling experiments together suggest that the F21W mutation neither significantly changes the nature of the catalytic intermediates, nor alters the mechanisms that have been established for peroxidase and peroxygenase activities in DHP.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, ORCID, NC State University Libraries, Crossref
Added: August 6, 2018
2017 journal article
Fluorinated polymer–photosensitizer conjugates enable improved generation of ROS for anticancer photodynamic therapy
Polymer Chemistry, 8(20), 3195–3202.
TL;DR:
Covalent conjugation of the photosensitizer to a fluorous polymer demonstrated enhanced singlet oxygen production, showing the potential to improve the PDT efficacy in hypoxic tumor environments.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, NC State University Libraries, Crossref
Added: August 6, 2018
2017 journal article
Interaction of Azole-Based Environmental Pollutants with the Coelomic Hemoglobin from Amphitrite ornata: A Molecular Basis for Toxicity
Biochemistry, 56(17), 2294–2303.
Contributors: N. McCombs n, T. Moreno-Chicano*, L. Carey n, S. Franzen n , M. Hough * & n
MeSH headings : Amino Acid Motifs; Animals; Benzimidazoles / chemistry; Benzimidazoles / metabolism; Benzimidazoles / toxicity; Catalytic Domain; Computational Biology; Environmental Pollutants / chemistry; Environmental Pollutants / metabolism; Environmental Pollutants / toxicity; Enzyme Inhibitors / chemistry; Enzyme Inhibitors / metabolism; Enzyme Inhibitors / toxicity; Fungicides, Industrial / chemistry; Fungicides, Industrial / metabolism; Fungicides, Industrial / toxicity; Hemoglobins / antagonists & inhibitors; Hemoglobins / chemistry; Hemoglobins / metabolism; Hydrogen Bonding; Hydrophobic and Hydrophilic Interactions; Imidazoles / chemistry; Imidazoles / metabolism; Imidazoles / toxicity; Indazoles / chemistry; Indazoles / metabolism; Indazoles / toxicity; Isoenzymes / antagonists & inhibitors; Isoenzymes / chemistry; Isoenzymes / metabolism; Kinetics; Ligands; Models, Molecular; Peroxidases / antagonists & inhibitors; Peroxidases / chemistry; Peroxidases / metabolism; Pesticides / chemistry; Pesticides / metabolism; Pesticides / toxicity; Polychaeta / enzymology; Recombinant Fusion Proteins / chemistry; Recombinant Fusion Proteins / metabolism; Recombinant Proteins / chemistry; Recombinant Proteins / metabolism; Triazoles / chemistry; Triazoles / metabolism; Triazoles / toxicity
TL;DR:
The results demonstrate a new mechanism by which azole pollutants can potentially disrupt hemoglobin function, thereby improving the understanding of their impact on infaunal organisms in marine and aquatic environments.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
14. Life Below Water
(OpenAlex)
Sources: Web Of Science, ORCID, NC State University Libraries, Crossref
Added: August 6, 2018
2017 journal article
Oxidation of pyrrole by dehaloperoxidase-hemoglobin: chemoenzymatic synthesis of pyrrolin-2-ones
CATALYSIS SCIENCE & TECHNOLOGY, 7(14), 3104–3118.
TL;DR:
The results demonstrate the breadth of chemical reactivity afforded by dehaloperoxidase, and provide further evidence for establishing DHP as a multifunctional globin with practical applications as a biocatalyst.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, ORCID, NC State University Libraries
Added: August 6, 2018
2017 journal article
Physalis Mottle Virus-Like Particles as Nanocarriers for Imaging Reagents and Drugs
Biomacromolecules, 18(12), 4141–4153.
MeSH headings : Animals; Cell Line; Cell Line, Tumor; Doxorubicin / chemistry; Drug Carriers / chemistry; HeLa Cells; Humans; Indicators and Reagents / chemistry; Lysine / chemistry; Maleimides / chemistry; Mice; Mitoxantrone / chemistry; Nanoparticles / chemistry; Neoplasms / diagnosis; Neoplasms / diagnostic imaging; Pharmaceutical Preparations / chemistry; Photosensitizing Agents / chemistry; RAW 264.7 Cells; Tymovirus / chemistry
TL;DR:
The results show that PhMV-derived VLPs provide a new platform technology for the delivery of imaging agents and drugs, with preferential uptake into cancer cells, and could be developed as multifunctional tools for cancer diagnosis and therapy.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Crossref, ORCID, NC State University Libraries
Added: February 24, 2020
2016 journal article
A Novel Approach for Rapid Preparation of Monophasic Microemulsions That Facilitates Penetration of Woody Biomass
ACS Sustainable Chemistry & Engineering, 4(3), 1665–1672.
author keywords: Surfactant-oil-water (SOW) system; Microemulsion; Surface tension; Kinetic viscosity; Wood penetration
UN Sustainable Development Goal Categories
6. Clean Water and Sanitation
(OpenAlex)
Sources: Web Of Science, ORCID, NC State University Libraries, Crossref
Added: August 6, 2018
2016 journal article
Development of a Highly Efficient Pretreatment Sequence for the Enzymatic Saccharification of Loblolly Pine Wood
ACS Sustainable Chemistry & Engineering, 4(7), 3669–3678.
author keywords: Pretreatment; Softwood; Delamination; XRD; Phosphoric acid; Saccharification efficiency
UN Sustainable Development Goal Categories
7. Affordable and Clean Energy
(Web of Science)
12. Responsible Consumption and Production
(Web of Science)
Sources: Web Of Science, ORCID, NC State University Libraries, Crossref
Added: August 6, 2018
2016 journal article
High Aspect Ratio Nanotubes Formed by Tobacco Mosaic Virus for Delivery of Photodynamic Agents Targeting Melanoma
ACS Biomaterials Science & Engineering, 2(5), 838–844.
Contributors: K. Lee, B. Carpenter n, A. Wen, n & N. Steinmetz
author keywords: viral nanoparticles; tobacco mosaic virus; photodynamic therapy; melanoma
TL;DR:
The delivery of a porphyrin-based photosensitizer encapsulated within a plant viral nanoparticle made use of the hollow, high aspect ratio nanotubes formed by the nucleoprotein components of tobacco mosaic virus to encapsulate the drug for delivery and targeting of cancer cells.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
Sources: Web Of Science, ORCID, NC State University Libraries, Crossref
Added: August 6, 2018
2016 journal article
Multi-functional hemoglobin dehaloperoxidases
Heme Peroxidases, (4), 218–244.
Source: NC State University Libraries
Added: August 6, 2018
2016 journal article
Nonmicrobial Nitrophenol Degradation via Peroxygenase Activity of Dehaloperoxidase-Hemoglobin fromAmphitrite ornata
Biochemistry, 55(17), 2465–2478.
Contributors: N. McCombs n, . J. D'Antonio, D. Barrios n, L. Carey n & n
MeSH headings : Animals; Catalysis; Hemoglobins / metabolism; Hydrogen Peroxide / metabolism; Mixed Function Oxygenases / metabolism; Nitrophenols; Oxidation-Reduction; Oxygen / metabolism; Peroxidases / metabolism; Polychaeta / enzymology
TL;DR:
The results demonstrate that there may be a much larger number of nonmicrobial enzymes that are underrepresented when it comes to understanding the degradation of persistent organic pollutants such as nitrophenols in the environment.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
14. Life Below Water
(OpenAlex)
Sources: Web Of Science, ORCID, NC State University Libraries, Crossref
Added: August 6, 2018
2016 journal article
Photosensitizer-Embedded Polyacrylonitrile Nanofibers as Antimicrobial Non-Woven Textile
Nanomaterials, 6(4), 77.
Contributors: S. Stanley n, F. Scholle n, J. Zhu n, Y. Lu n, X. Zhang n , X. Situ n, n
author keywords: photodynamic inactivation; singlet oxygen; antibacterial; antiviral; photobiocidal; polyacrylonitrile; photosensitizer; porphyrin
TL;DR:
The results demonstrate the potential of photosensitizer-embedded polyacrylonitrile nanofibers to serve as scalable scaffolds for anti-infective or self-sterilizing materials against both bacteria and viruses when employing a photodynamic inactivation mode of action.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
9. Industry, Innovation and Infrastructure
(OpenAlex)
Sources: Web Of Science, ORCID, NC State University Libraries, Crossref
Added: August 6, 2018
2016 journal article
Utilizing Viral Nanoparticle/Dendron Hybrid Conjugates in Photodynamic Therapy for Dual Delivery to Macrophages and Cancer Cells
Bioconjugate Chemistry, 27(5), 1227–1235.
Contributors: A. Wen, K. Lee, P. Cao, K. Pangilinan, B. Carpenter n, P. Lam, F. Veliz, n , R. Advincula, N. Steinmetz
MeSH headings : Animals; Comovirus / chemistry; Dendrimers / chemistry; Drug Carriers / chemistry; Macrophages / metabolism; Melanoma, Experimental / pathology; Mice; Nanoparticles / chemistry; Photochemotherapy; Photosensitizing Agents / chemistry; Photosensitizing Agents / metabolism; RAW 264.7 Cells
TL;DR:
Overall, effective elimination of both macrophage and tumor cells at low micromolar concentrations of the photosensitizer when delivered with the CPMV bioconjugate is demonstrated, thereby potentially improving melanoma treatment.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
Sources: Web Of Science, ORCID, NC State University Libraries, Crossref
Added: August 6, 2018
2015 journal article
Antiviral, Antifungal and Antibacterial Activities of a BODIPY-Based Photosensitizer
Molecules, 20(6), 10604–10621.
Contributors: B. Carpenter n, X. Situ n, F. Scholle n, J. Bartelmess n, W. Weare n & n
author keywords: photodynamic therapy; singlet oxygen; antibacterial; antiviral; antifungal; photobiocidal
MeSH headings : Anti-Bacterial Agents; Anti-Infective Agents / chemistry; Anti-Infective Agents / pharmacology; Antifungal Agents; Antiviral Agents; Boron Compounds / chemistry; Dose-Response Relationship, Drug; Humans; Microbial Sensitivity Tests; Photosensitizing Agents / chemistry; Photosensitizing Agents / pharmacology
TL;DR:
The results demonstrate that DIMPy-BODIPY exhibits antiviral, antibacterial and antifungal photodynamic inactivation at nanomolar concentrations and short illumination times.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: ORCID, NC State University Libraries, Crossref, NC State University Libraries
Added: August 6, 2018
2015 chapter
Chapter 10. Multi-functional Hemoglobin Dehaloperoxidases
In Heme Peroxidases: Vol. 2016-January (pp. 218–244).
Contributors: S. Franzen n, n , L. Lebioda* & J. Dawson*
TL;DR:
An overview of the peroxidase function of DHP is presented, and the mechanism of the oxidative dehalogenation reaction carried out by this enzyme when initiated from both the ferric and oxyferrous states by the addition of hydrogen peroxide is described.
(via Semantic Scholar)
Sources: ORCID, Crossref, NC State University Libraries
Added: December 15, 2020
2015 journal article
Dendritic near-IR absorbing zinc phthalocyanines for antimicrobial photodynamic therapy
Tetrahedron Letters, 56(23), 3541–3545.
Contributors: D. Muli, B. Carpenter*, M. Mayukh, * & D. McGrath
author keywords: Non-aggregated; Water soluble; Click chemistry; Singlet oxygen; Methylene blue
TL;DR:
Both ZnPcs showed negligible dark toxicity on bacteria and yeast with 10 μM 1a and 1b, and aggregation studies indicate that non-peripherally substituted 1b is significantly less aggregated in aqueous media than peripherally substitution 1a .
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
6. Clean Water and Sanitation
(OpenAlex)
Sources: Web Of Science, ORCID, NC State University Libraries, Crossref
Added: August 6, 2018
2015 journal article
Synthesis, Characterization, and Antimicrobial Efficacy of Photomicrobicidal Cellulose Paper
BIOMACROMOLECULES, 16(8), 2482–2492.
Contributors: B. Carpenter*, F. Scholle*, H. Sadeghifar*, A. Francis*, J. Boltersdorf*, W. Weare*, D. Argyropoulos* , P. Maggard* , *
MeSH headings : Anti-Infective Agents / administration & dosage; Anti-Infective Agents / chemical synthesis; Anti-Infective Agents / chemistry; Cellulose / administration & dosage; Cellulose / chemical synthesis; Cellulose / chemistry; Enterococcus faecium / drug effects; Humans; Klebsiella pneumoniae / drug effects; Light; Microbial Sensitivity Tests; Paper; Photosensitizing Agents / chemical synthesis; Photosensitizing Agents / chemistry; Porphyrins / administration & dosage; Porphyrins / chemical synthesis; Porphyrins / chemistry; Pseudomonas aeruginosa / drug effects; Staphylococcus aureus / drug effects
TL;DR:
The results demonstrate the potential of cellulose materials to serve as scalable scaffolds for anti-infective or self-sterilizing materials against both bacteria and viruses when employing a photodynamic inactivation mode of action.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, ORCID, NC State University Libraries
Added: August 6, 2018
2014 journal article
Peroxygenase and Oxidase Activities of Dehaloperoxidase-Hemoglobin from Amphitrite ornata
Journal of the American Chemical Society, 136(22), 7914–7925.
Contributors: D. Barrios n, . J. D'Antonio, N. McCombs n, J. Zhao n, S. Franzen n , A. Schmidt n, L. Sombers n , n
MeSH headings : Animals; Catalytic Domain; Hemoglobins / chemistry; Hemoglobins / metabolism; Indoles / chemistry; Indoles / metabolism; Mixed Function Oxygenases / metabolism; Models, Molecular; Oxidoreductases / metabolism; Oxygen / chemistry; Oxygen Consumption; Oxygen Radioisotopes; Polychaeta / enzymology; Protein Conformation
TL;DR:
The marine globin dehaloperoxidase‐hemoglobin (DHP) from Amphitrite ornata was found to catalyze the H2O2‐dependent oxidation of monohaloindoles, a previously unreported class of substrate for DHP, and non‐enzymatic and anaerobic controls suggest a novel oxidase activity for D HP.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
14. Life Below Water
(OpenAlex)
Sources: Web Of Science, ORCID, NC State University Libraries, Crossref
Added: August 6, 2018
2013 journal article
Tyrosyl Radicals in Dehaloperoxidase
Journal of Biological Chemistry, 288(46), 33470–33482.
Contributors: R. Dumarieh n, . J. D'Antonio, A. Deliz-Liang n, T. Smirnova n , D. Svistunenko * & n
author keywords: Hemoglobin; Iron; Peroxidase; Radicals; Tyrosine; Compound ES; Compound I; Compound II; Dehaloperoxidase; Ferryl
MeSH headings : Adaptation, Physiological; Animals; Hemoglobins / chemistry; Hemoglobins / genetics; Hemoglobins / metabolism; Oxidation-Reduction; Oxygen / chemistry; Oxygen / metabolism; Peroxidase / chemistry; Peroxidase / genetics; Peroxidase / metabolism; Peroxidases / chemistry; Peroxidases / genetics; Peroxidases / metabolism; Polychaeta / enzymology; Protein Binding; Tyrosine / analogs & derivatives; Tyrosine / chemistry; Tyrosine / genetics; Tyrosine / metabolism
TL;DR:
The results indicate that radicals form on all three tyrosines in DHP, likely an evolutionary adaptation allowing DHP to avoid self-inflicted damage in the oxidative environment.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Crossref, ORCID, NC State University Libraries
Added: February 24, 2020
2013 journal article
Tyrosyl radicals in dehaloperoxidase how nature deals with evolving an oxygen-binding globin to a biologically relevant peroxidase
Journal of Biological Chemistry, 288(46), 33470–33482.
Source: NC State University Libraries
Added: August 6, 2018
2012 journal article
Ferric haem forms of Mycobacterium tuberculosis catalase-peroxidase probed by EPR spectroscopy: Their stability and interplay with pH
Biochimie, 94(6), 1274–1280.
Contributors: D. Svistunenko *, J. Worrall *, S. Chugh*, S. Haigh*, n & P. Nicholls *
author keywords: Catalase-peroxidase; Mycobacterium tuberculosis; High spin; HS; EPR
MeSH headings : Bacterial Proteins / chemistry; Catalase / chemistry; Cold Temperature; Electron Spin Resonance Spectroscopy; Enzyme Stability; Ferric Compounds / chemistry; Heme / chemistry; Hydrogen-Ion Concentration; Models, Molecular; Mycobacterium tuberculosis / enzymology; Peroxidases / chemistry
TL;DR:
Low temperature EPR spectroscopy was used to characterise Mycobacterium tuberculosis catalase-peroxidase in its resting ferric haem state, indicating that the mechanism of the time-dependent transition from one high spin ferrics haem form to another must be more complex than a simple single site oxidation.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
6. Clean Water and Sanitation
(Web of Science; OpenAlex)
Sources: Web Of Science, ORCID, NC State University Libraries, Crossref
Added: August 6, 2018
2012 journal article
Nonphotochemical Base-Catalyzed Hydroxylation of 2,6-Dichloroquinone by H2O2Occurs by a Radical Mechanism
The Journal of Physical Chemistry B, 116(5), 1666–1676.
Contributors: S. Franzen* , K. Sasan, B. Sturgeon*, B. Lyon*, B. Battenburg*, H. Gracz*, R. Dumariah, *
MeSH headings : Animals; Benzoquinones / chemistry; Benzoquinones / metabolism; Catalysis; Chlorophenols / metabolism; Hydrogen Peroxide / metabolism; Peroxidases / metabolism; Polychaeta / enzymology; Polychaeta / metabolism
TL;DR:
The control experiments and precedents in studies of other peroxidases lead to the conclusion that hydroxylation will be observed following any process that leads to the formation of the 2,6-DCQ at pH > 7, regardless of the catalyst used in the2,4, 6-TCP oxidation reaction.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, ORCID, NC State University Libraries, Crossref
Added: August 6, 2018
2012 article
Porphyrin-Cellulose Nanocrystals: A Photobactericidal Material that Exhibits Broad Spectrum Antimicrobial Activity (vol 88, pg 495, 2012)
PHOTOCHEMISTRY AND PHOTOBIOLOGY, Vol. 88, pp. 1034–1034.
Contributors: B. Carpenter n, E. Feese n, H. Sadeghifar n, D. Argyropoulos n & n
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, ORCID, NC State University Libraries
Added: August 6, 2018
2012 journal article
Porphyrin-Cellulose Nanocrystals: A Photobactericidal Material that Exhibits Broad Spectrum Antimicrobial Activity†
Photochemistry and Photobiology, 88(3), 527–536.
Contributors: B. Carpenter n, E. Feese n, H. Sadeghifar n, D. Argyropoulos n & n
MeSH headings : Acinetobacter baumannii / drug effects; Anti-Bacterial Agents / pharmacology; Cellulose / chemistry; Drug Resistance, Microbial; Microscopy, Confocal; Microscopy, Fluorescence; Nanoparticles; Photochemotherapy; Porphyrins / chemistry; Spectrophotometry, Ultraviolet; Staphylococcus aureus / drug effects
TL;DR:
Research into alternative materials such as CNC‐Por may lead to their application in hospitals and healthcare‐related industries wherein novel materials with the capability of reducing the rates of transmission of a wide range of bacteria, particularly antibiotic resistant strains, are desired.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, Crossref, ORCID, NC State University Libraries
Added: August 6, 2018
2012 journal article
Synthesis and characterization of new trinuclear copper complexes
Inorganica Chimica Acta, 389, 131–137.
Contributors: * , A. Rheingold *, M. Siegler * & K. Karlin *
author keywords: Trinuclear copper; Copper(I) and copper(II); Copper clusters; Trinucleating ligands; Cu clusters in biology
TL;DR:
The approach towards modelling the copper cluster active sites of nitrous oxide reductase and the multicopper oxidases/oxygenases is described and two mesitylene-based trinucleating ligands are synthesized, which employ bis( 2-picolyl)amine (PY1) and bis(2-pyridylethyl)amine(PY2) tridentate copper chelates, respectively.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
6. Clean Water and Sanitation
(OpenAlex)
Sources: Crossref, ORCID, NC State University Libraries
Added: February 24, 2020
2012 journal article
The Role of the Distal Histidine in H2O2 Activation and Heme Protection in both Peroxidase and Globin Functions
The Journal of Physical Chemistry B, 116(40), 12065–12077.
Contributors: J. Zhao n, V. De Serrano n, R. Dumarieh n, M. Thompson n, n & S. Franzen n
MeSH headings : Biocatalysis; Chlorophenols / chemistry; Chlorophenols / metabolism; Heme / chemistry; Heme / metabolism; Hemoglobin A / chemistry; Hemoglobin A / metabolism; Histidine / chemistry; Histidine / genetics; Histidine / metabolism; Hydrogen Peroxide / chemistry; Hydrogen Peroxide / metabolism; Models, Molecular; Molecular Structure; Mutation; Oxidation-Reduction; Peroxidases / chemistry; Peroxidases / metabolism; Quinones / chemistry; Quinones / metabolism
TL;DR:
The distal histidine mutations of dehaloperoxidase-hemoglobin A to aspartate (H55D) and asparagine and H55N have been prepared to study the role played by the distal Histidine in both activation and protection against oxidation by radicals in heme proteins.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, ORCID, NC State University Libraries, Crossref
Added: August 6, 2018
2012 journal article
The dehaloperoxidase paradox
Biochimica Et Biophysica Acta (BBA) - Proteins and Proteomics, 1824(4), 578–588.
Contributors: S. Franzen n , M. Thompson n & n
author keywords: Peroxidase; Competitive inhibition; Hemoglobin; Phenol; Marine; Enzyme
MeSH headings : Amino Acid Motifs; Amino Acid Substitution; Animals; Enzyme Inhibitors / chemistry; Free Radicals / chemistry; Heme / chemistry; Hemoglobins / antagonists & inhibitors; Hemoglobins / chemistry; Hemoglobins / genetics; Humans; Hydrogen-Ion Concentration; Isoenzymes / antagonists & inhibitors; Isoenzymes / chemistry; Isoenzymes / genetics; Kinetics; Models, Molecular; Oxidation-Reduction; Peroxidases / antagonists & inhibitors; Peroxidases / chemistry; Peroxidases / genetics; Phenols / chemistry; Protein Binding
TL;DR:
The unresolved aspects of the reaction scheme that leads to the apparent paradox of Amphitrite ornata are explored in the context of control of reactivity radical pathways and reactivity by the motion of the distal histidine, H55, which is coupled to the binding of substrate and inhibitor.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, ORCID, NC State University Libraries, Crossref
Added: August 6, 2018
2011 journal article
Decay of Compound ES in Dehaloperoxidase-Hemoglobin
Biophysical Journal, 100(3), 194a.
TL;DR:
A kinetic model of the experimental data suggests that formation of Compound RH or the Tyr38 radical are two alternative routes ofcompound ES decay, a product of safe termination of the two oxidizing equivalents of H2O2 when no substrate is available.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
6. Clean Water and Sanitation
(OpenAlex)
Sources: Crossref, NC State University Libraries
Added: February 24, 2020
2011 journal article
Functional Consequences of the Creation of an Asp-His-Fe Triad in a 3/3 Globin
Biochemistry, 50(44), 9664–9680.
Contributors: E. Dantonio n, J. Dantonio n, V. De Serrano n, H. Gracz n, M. Thompson n, n , E. Bowden n , S. Franzen n
MeSH headings : Animals; Aspartic Acid / chemistry; Aspartic Acid / genetics; Catalytic Domain / genetics; Crystallography, X-Ray; Electrochemistry; Globins / chemistry; Globins / genetics; Helminth Proteins / chemistry; Helminth Proteins / genetics; Histidine / chemistry; Histidine / genetics; Magnetic Resonance Spectroscopy; Mutagenesis, Site-Directed; Polychaeta / enzymology; Polychaeta / genetics; Spectrophotometry, Ultraviolet; Spectrum Analysis, Raman
TL;DR:
The results suggest that the proximal charge relay in peroxidases regulate the redox potential of the heme Fe but that the trans effect is a carefully balanced property that can both activate H( 2)O(2) and attract ligation by the distal histidine.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, ORCID, NC State University Libraries, Crossref
Added: August 6, 2018
2011 journal article
Photobactericidal Porphyrin-Cellulose Nanocrystals: Synthesis, Characterization, and Antimicrobial Properties
Biomacromolecules, 12(10), 3528–3539.
Contributors: E. Feese n, H. Sadeghifar*, H. Gracz*, D. Argyropoulos* & *
MeSH headings : Anti-Bacterial Agents / chemical synthesis; Anti-Bacterial Agents / pharmacology; Azides / chemistry; Cellulose / chemistry; Click Chemistry / methods; Disinfectants / chemical synthesis; Disinfectants / pharmacology; Escherichia coli / drug effects; Escherichia coli / growth & development; Escherichia coli / radiation effects; Humans; Light; Magnetic Resonance Spectroscopy; Microbial Sensitivity Tests; Microbial Viability / drug effects; Microbial Viability / radiation effects; Molecular Structure; Mycobacterium smegmatis / drug effects; Mycobacterium smegmatis / growth & development; Mycobacterium smegmatis / radiation effects; Nanoparticles / chemistry; Nanotechnology / methods; Photosensitizing Agents / chemical synthesis; Photosensitizing Agents / pharmacology; Porphyrins / chemistry; Species Specificity; Staphylococcus aureus / drug effects; Staphylococcus aureus / growth & development; Staphylococcus aureus / radiation effects; Thermogravimetry
TL;DR:
The synthesis, properties, and activity of CNC-Por (5) described herein serve as a benchmark toward the overall objectives of developing novel, potent, bioactive, photobactericidal materials that are effective against a range of bacteria, with potential utilization in the health care and food preparation industries.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, ORCID, NC State University Libraries, Crossref
Added: August 6, 2018
2011 journal article
Reactivity of Deoxy- and Oxyferrous Dehaloperoxidase B fromAmphitrite ornata:Identification of Compound II and Its Ferrous–Hydroperoxide Precursor
Biochemistry, 50(27), 5999–6011.
MeSH headings : Animals; Electron Spin Resonance Spectroscopy; Enzyme Precursors / chemistry; Enzyme Precursors / metabolism; Ferric Compounds / chemistry; Ferric Compounds / metabolism; Ferrous Compounds / chemistry; Ferrous Compounds / metabolism; Hydrogen Peroxide / chemistry; Hydrogen Peroxide / metabolism; Isoenzymes / chemistry; Isoenzymes / metabolism; Peroxidases / chemistry; Peroxidases / metabolism; Polychaeta / enzymology; Spectrophotometry, Ultraviolet
TL;DR:
The data presented herein provide a link between the peroxidase and oxygen transport activities, which furthers the understanding of how this bifunctional enzyme is able to unite its two inherent functions in one system.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, ORCID, NC State University Libraries, Crossref
Added: August 6, 2018
2011 journal article
Site(s) of Tyrosyl Radical Formation in Dehaloperoxidase A and B
Biophysical Journal, 100(3), 379a.
Sources: Crossref, NC State University Libraries
Added: February 24, 2020
2010 journal article
Characterization of the Radical Intermediates of Dehaloperoxidase A and B from Amphitrite Ornata
Biophysical Journal, 98(3), 641a.
UN Sustainable Development Goal Categories
14. Life Below Water
(OpenAlex)
Sources: Crossref, NC State University Libraries
Added: February 24, 2020
2010 journal article
Compound ES of Dehaloperoxidase Decays via Two Alternative Pathways Depending on the Conformation of the Distal Histidine
Journal of the American Chemical Society, 132(49), 17501–17510.
Contributors: M. Thompson n, S. Franzen n , n , B. Reeder n & D. Svistunenko n
MeSH headings : Animals; Electron Spin Resonance Spectroscopy; Free Radicals / metabolism; Heme / chemistry; Heme / metabolism; Hemoglobins / chemistry; Hemoglobins / metabolism; Histidine / chemistry; Histidine / metabolism; Hydrogen Peroxide / metabolism; Kinetics; Models, Molecular; Molecular Conformation; Peroxidases / chemistry; Peroxidases / metabolism; Polychaeta / chemistry; Polychaeta / enzymology; Polychaeta / metabolism; Protein Conformation
TL;DR:
A kinetic model of the experimental data suggests that formation of Compound RH and formation of the Tyr38 radical are two alternative routes ofcompound ES decay, a product of safe termination of the two oxidizing equivalents of H2O2 when no substrate is available.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
6. Clean Water and Sanitation
(OpenAlex)
Sources: Web Of Science, ORCID, NC State University Libraries, Crossref
Added: August 6, 2018
2010 journal article
Isoniazid-resistance conferring mutations in Mycobacterium tuberculosis KatG: Catalase, peroxidase, and INH-NADH adduct formation activities
Protein Science, 19(3), 458–474.
Contributors: C. Cade n, A. Dlouhy n, K. Medzihradszky *, S. Salas-Castillo* & n
author keywords: catalase-peroxidase; KatG; isoniazid; INH; heme; crosslink
MeSH headings : Antitubercular Agents / metabolism; Antitubercular Agents / pharmacology; Bacterial Proteins / chemistry; Bacterial Proteins / genetics; Bacterial Proteins / metabolism; Catalase / chemistry; Catalase / genetics; Catalase / metabolism; Catalytic Domain; Drug Resistance, Bacterial / genetics; Humans; Isoniazid / metabolism; Isoniazid / pharmacology; Mutagenesis, Site-Directed; Mycobacterium tuberculosis / drug effects; Mycobacterium tuberculosis / enzymology; Mycobacterium tuberculosis / genetics; NAD / metabolism; Peroxidase / genetics; Protein Conformation; Tuberculosis, Multidrug-Resistant / microbiology
TL;DR:
The results demonstrate that residue location plays a critical role in determining INH‐resistance mechanisms associated with INH activation; however, different mutations at the same location can produce vastly different reactivities that are oxidant‐specific.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: ORCID, NC State University Libraries, Crossref, NC State University Libraries
Added: August 6, 2018
2010 journal article
Spectroscopic and Mechanistic Investigations of Dehaloperoxidase B fromAmphitrite ornata
Biochemistry, 49(31), 6600–6616.
Contributors: . J. D'Antonio, . E.L. D'Antonio n, M. Thompson n, E. Bowden n , S. Franzen n , T. Smirnova n , n
MeSH headings : Animals; Cloning, Molecular; Halogenation; Hemoglobins; Iron; Kinetics; Oxidation-Reduction; Oxygen / metabolism; Peroxidases / genetics; Peroxidases / metabolism; Polychaeta / enzymology; Spectrum Analysis
TL;DR:
A novel reaction pathway is demonstrated in which the products of the oxidative dehalogenation of trihalophenols (dihaloquinones) are themselves capable of inducing formation of oxyferrous DHP B, and an updated catalytic cycle for DHP is proposed.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, ORCID, NC State University Libraries, Crossref
Added: August 6, 2018
2010 journal article
Structure of dehaloperoxidase B at 1.58 A resolution and structural characterization of the AB dimer from Amphitrite ornata
Acta Crystallographica Section D Biological Crystallography, 66(5), 529–538.
Contributors: V. De Serrano n, J. Dantonio n, S. Franzen n & n
MeSH headings : Animals; Crystallography, X-Ray; Hemoglobins / chemistry; Hemoglobins / metabolism; Histidine / chemistry; Isoenzymes / chemistry; Isoenzymes / metabolism; Models, Molecular; Peroxidases / chemistry; Peroxidases / metabolism; Polychaeta / enzymology; Protein Conformation
TL;DR:
These structural investigations of DHP B provide insights that may relate to the mechanistic details of the H(2)O(2)-dependent oxidative dehalogenation reaction catalyzed by dehaloperoxidase, present a clearer description of the function of specific residues in DHP at the molecular level and lead to a better understanding of the paradigms of globin structure-function relationships.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
14. Life Below Water
(OpenAlex)
Sources: ORCID, Crossref, NC State University Libraries
Added: December 15, 2020
2010 journal article
Structure of dehaloperoxidase B at 1.58 angstrom resolution and structural characterization of the AB dimer from Amphitrite ornata
Acta Crystallographica. Section D, Biological Crystallography, 66, 529–538.
Source: NC State University Libraries
Added: August 6, 2018
2009 journal article
Characterization of Dehaloperoxidase Compound ES and Its Reactivity with Trihalophenols†
Biochemistry, 48(5), 995–1005.
Contributors: J. Feducia n , R. Dumarieh n, L. Gilvey n, T. Smirnova n , S. Franzen n & n
MeSH headings : Animals; Binding Sites; Chlorophenols / chemistry; Chlorophenols / metabolism; Crystallography, X-Ray; Cytochrome-c Peroxidase / chemistry; Cytochrome-c Peroxidase / metabolism; Electron Transport Complex IV / chemistry; Electron Transport Complex IV / metabolism; Hemoglobins / chemistry; Hemoglobins / metabolism; Peroxidases / chemistry; Peroxidases / metabolism; Polychaeta / enzymology
TL;DR:
It is demonstrated that the first detectable intermediate following the addition of hydrogen peroxide to ferric DHP contains both a ferryl heme and a tyrosyl radical, analogous to Compound ES of cytochrome c peroxidase.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, ORCID, NC State University Libraries, Crossref
Added: August 6, 2018
2009 journal article
Highly efficient in vitro photodynamic inactivation of Mycobacterium smegmatis
Journal of Antimicrobial Chemotherapy, 64(4), 782–785.
Contributors: E. Feese n & n
author keywords: multidrug resistant; TB; photosensitizers
MeSH headings : Colony Count, Microbial; Light; Microbial Viability / radiation effects; Mycobacterium smegmatis / radiation effects; Photosensitizing Agents / pharmacology
TL;DR:
The best results demonstrate that PDI of M. smegmatis can achieve a noteworthy 5-6 log unit reduction in cfu (99.999% + viable cell eradication) when cationic PSs are employed in the nanomolar concentration range.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
Sources: Web Of Science, ORCID, NC State University Libraries, Crossref
Added: August 6, 2018
2009 journal article
Molecular Oxygen and Sulfur Reactivity of a Cyclotriveratrylene Derived Trinuclear Copper(I) Complex
Inorganic Chemistry, 48(17), 8342–8356.
Contributors: D. Maiti *, J. Woertink*, * , E. Solomon * & K. Karlin *
MeSH headings : Copper / chemistry; Crystallography, X-Ray; Ligands; Models, Molecular; Molecular Structure; Organometallic Compounds / chemical synthesis; Organometallic Compounds / chemistry; Oxygen / chemistry; Polycyclic Compounds / chemistry; Sulfur / chemistry
TL;DR:
The design and synthesis of a cyclotriveratrylene (CTV)-based trinucleating ligand, CTV-TMPA, which employs tetradentate tris(2-pyridylmethyl)-amine chelates (TMPA) for their copper ion binding sites was designed and synthesized.
(via Semantic Scholar)
Sources: Crossref, ORCID, NC State University Libraries
Added: February 24, 2020
2009 journal article
Spectroscopic Probes of the Reactive Intermediates of Dehaloperoxidase from Amphitrite ornata
Biophysical Journal, 96(3), 437a.
TL;DR:
While unreactive toward further oxidation, Compound RH can be reduced and subsequently bind dioxygen, generating oxyferrous DHP, which may represent the catalytic link between the peroxidase and oxygen-transport activities in this bifunctional protein.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
14. Life Below Water
(OpenAlex)
Sources: Crossref, NC State University Libraries
Added: February 24, 2020
2008 book review
Book Review of Organic Synthesis with Enzymes in Non-Aqueous Media
[Review of Organic Synthesis with Enzymes in Non-Aqueous Media, by G. Carrea & S. Riva]. Journal of the American Chemical Society, 130(45), 15218–15219.
Sources: Crossref, NC State University Libraries
Added: January 23, 2021
2007 journal article
Further Insights into the Spectroscopic Properties, Electronic Structure, and Kinetics of Formation of the Heme−Peroxo−Copper Complex [(F8TPP)FeIII−(O22-)−CuII(TMPA)]+
Inorganic Chemistry, 46(10), 3889–3902.
Contributors: * , E. Chufán*, D. Del Río*, E. Solomon *, C. Krebs *, H. Boi*, H. Huang *, P. Moënne-Loccoz *
MeSH headings : Cold Temperature; Copper / chemistry; Deuterium / chemistry; Electrochemistry; Fluorine Radioisotopes / chemistry; Heme / chemistry; Iron Compounds / chemistry; Kinetics; Magnetic Resonance Spectroscopy; Organometallic Compounds / chemistry; Oxygen / chemistry; Peroxides / chemistry; Solvents; Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization; Spectroscopy, Mossbauer; Spectrum Analysis, Raman
Sources: ORCID, Crossref, NC State University Libraries
Added: December 15, 2020
2005 journal article
Correlation between Isoniazid Resistance and Superoxide Reactivity in Mycobacterium tuberculosis KatG
Journal of the American Chemical Society, 127(38), 13428–13442.
Contributors: * , K. Medzihradszky *, F. Rusnak* & P. Ortiz De Montellano*
MeSH headings : Bacterial Proteins / chemistry; Catalase / chemistry; Drug Resistance, Microbial; Free Radicals / chemistry; Isoniazid / chemistry; Isoniazid / pharmacology; Mycobacterium tuberculosis / drug effects; Mycobacterium tuberculosis / enzymology; Oxidation-Reduction; Oxygen Consumption / drug effects; Structure-Activity Relationship; Time Factors
TL;DR:
A mechanism for isoniazid resistance which accounts for the observed reactivity for each of the compound I, II, and III intermediates is proposed and suggests that the compound III pathway may be the primary factor in determining overall isoniaZid resistance by specific KatG mutants, with secondary contributions arising from the compounds I and II pathways.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(OpenAlex)
Sources: ORCID, Crossref, NC State University Libraries
Added: December 15, 2020
2005 journal article
Role of the Met−Tyr−Trp Cross-Link inMycobacterium tuberculosis Catalase-Peroxidase (KatG) As Revealed by KatG(M255I)
Biochemistry, 44(46), 15093–15105.
Contributors: * , K. Medzihradszky * & P. Ortiz De Montellano*
MeSH headings : Amino Acid Sequence; Bacterial Proteins / chemistry; Bacterial Proteins / genetics; Catalase / chemistry; Catalase / genetics; Chromatography, High Pressure Liquid; Cross-Linking Reagents; Mass Spectrometry; Methionine / chemistry; Molecular Sequence Data; Peptide Fragments / chemistry; Peracetic Acid / chemistry; Peroxidases / analysis; Spectrophotometry; Spectrophotometry, Ultraviolet; Tryptophan / chemistry; Tyrosine / chemistry
TL;DR:
Insight into the contributions of the individual Tyr-Trp and Met-Tyr cross-links to catalase activity is presented, as is the overall contribution of the Met-tyr-trp cross-link to the structure-function-spectroscopy relationship and catalases-peroxidase mechanism in KatG.
(via Semantic Scholar)
Sources: ORCID, Crossref, NC State University Libraries
Added: December 15, 2020
2005 journal article
The Met-Tyr-Trp Cross-link in Mycobacterium tuberculosis Catalase-peroxidase (KatG)
Journal of Biological Chemistry, 280(24), 22651–22663.
Contributors: * , G. Knudsen *, K. Medzihradszky * & P. Ortiz De Montellano*
MeSH headings : Amino Acid Sequence; Bacterial Proteins / chemistry; Bacterial Proteins / physiology; Binding Sites; Catalase / chemistry; Catalase / physiology; Catalysis; Chromatography, High Pressure Liquid; Cross-Linking Reagents / pharmacology; Crystallography, X-Ray; Heme / chemistry; Hydrogen Peroxide / chemistry; Kinetics; Mass Spectrometry; Methionine / chemistry; Models, Chemical; Models, Molecular; Molecular Sequence Data; Mycobacterium tuberculosis / enzymology; Peptides / chemistry; Peracetic Acid / chemistry; Plasmids / metabolism; Protein Binding; Recombinant Proteins / chemistry; Spectrophotometry; Time Factors; Trypsin / pharmacology; Tryptophan / chemistry; Tyrosine / chemistry; Ultraviolet Rays
TL;DR:
The structure-function-spectroscopy relationship in KatG is discussed with relevance to the role that the Met-Tyr-Trp cross-link plays in the catalase-peroxidase mechanism.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(OpenAlex)
Sources: ORCID, Crossref, NC State University Libraries
Added: December 15, 2020
2004 journal article
Heme-copper/dioxygen adduct formation relevant to cytochrome c oxidase: spectroscopic characterization of [(6L)FeIII-(O22?)-CuII]+
JBIC Journal of Biological Inorganic Chemistry, 10(1), 63–77.
Contributors: * , H. Huang *, P. Moënne-Loccoz, J. Stasser*, N. Blackburn *, A. Woods *, R. Cotter *, C. Incarvito*, A. Rheingold *, K. Karlin *
author keywords: heme-copper; iron(II)-copper(I) complex; peroxo complex; mass spectrometry; resonance Raman spectroscopy; dioxygen adduct; model compound
MeSH headings : Binding Sites; Copper / chemistry; Copper / metabolism; Electron Transport Complex IV / chemistry; Electron Transport Complex IV / metabolism; Heme / chemistry; Heme / metabolism; Molecular Conformation; Oxygen / chemistry; Oxygen / metabolism; Solvents; Spectrum Analysis; Temperature
TL;DR:
1H and 2H NMR spectroscopy reveals that 2 is the first heme-copper peroxo complex which is high-spin, with downfield-shifted pyrrole resonances and upfield shifted peaks at δ= −22, −35, and −40 ppm, similar to the pattern observed for the μ-oxocomplex.
(via Semantic Scholar)
Sources: ORCID, Crossref, NC State University Libraries
Added: December 15, 2020
2004 journal article
Superoxide Reactivity of KatG: Insights into Isoniazid Resistance Pathways in TB
Journal of the American Chemical Society, 126(15), 4772–4773.
MeSH headings : Antitubercular Agents / pharmacology; Bacterial Proteins; Catalase; Drug Resistance, Bacterial; Isoniazid / pharmacology; Mycobacterium tuberculosis / drug effects; Mycobacterium tuberculosis / enzymology; Mycobacterium tuberculosis / genetics; Oxidoreductases / genetics; Oxidoreductases / metabolism; Point Mutation; Pulse Radiolysis; Superoxides / metabolism
TL;DR:
A mechanism capable of correlating the inability for the oxyferrous intermediate of KatG(S315T) to oxidize ("activate") INH to the suppressed formation of the INH-NADH adduct, thereby leading to INH resistance in Mycobacterium tuberculosis is proposed.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
6. Clean Water and Sanitation
(OpenAlex)
Sources: Crossref, ORCID, NC State University Libraries
Added: August 28, 2020
2003 journal article
Synthesis and Characterization of Reduced Heme and Heme/Copper Carbonmonoxy Species
Inorganic Chemistry, 42(9), 3016–3025.
Contributors: R. Kretzer*, * , E. Lebeau*, H. Liang* & K. Karlin *
MeSH headings : Copper / chemistry; Crystallography, X-Ray; Ferrous Compounds / chemical synthesis; Ferrous Compounds / chemistry; Heme / chemistry; Indicators and Reagents; Magnetic Resonance Spectroscopy; Molecular Structure; Organometallic Compounds / chemical synthesis; Organometallic Compounds / chemistry; Oxidation-Reduction
TL;DR:
Experiments repeated in acetonitrile, acetone, toluene, and dichloromethane showed similar spectroscopic data, with binding of CO resulting in a change from five-coordinate, high-spin Fe(II) to six-coordinated, low-spinFe(II), as evidenced by the upfield shift of the pyrrole resonances to the diamagnetic region.
(via Semantic Scholar)
Sources: Crossref, ORCID, NC State University Libraries
Added: August 28, 2020
2003 journal article
Synthesis, Characterization, and Laser Flash Photolysis Reactivity of a Carbonmonoxy Heme Complex
Inorganic Chemistry, 42(17), 5211–5218.
Contributors: D. Thompson*, R. Kretzer*, E. Lebeau*, D. Scaltrito*, * , K. Lam*, A. Rheingold *, K. Karlin *, G. Meyer *
MeSH headings : Carbon Monoxide / chemistry; Crystallography, X-Ray; Ferrous Compounds / chemistry; Heme / chemistry; Kinetics; Lasers; Magnetic Resonance Spectroscopy; Metalloporphyrins / chemistry; Photolysis; Spectrophotometry, Infrared
TL;DR:
The synthesis, characterization, and flash photolysis study of [(F(8)TPP)Fe(II)(CO)(THF)] is presented, to more fully understand the intricacies of solvent-ligand binding (as compared to CO rebinding to the photolyzed heme).
(via Semantic Scholar)
Sources: ORCID, Crossref, NC State University Libraries
Added: December 15, 2020
2002 journal article
Low-Temperature UV−Visible and NMR Spectroscopic Investigations of O2 Binding to (6L)FeII, a Ferrous Heme Bearing Covalently Tethered Axial Pyridine Ligands
Inorganic Chemistry, 41(9), 2400–2407.
Contributors: * & K. Karlin *
MeSH headings : Electron Transport Complex IV / chemistry; Ferrous Compounds / chemical synthesis; Ferrous Compounds / chemistry; Furans / chemistry; Heme / chemistry; Magnetic Resonance Spectroscopy; Metalloporphyrins / chemical synthesis; Metalloporphyrins / chemistry; Methylene Chloride / chemistry; Models, Molecular; Molecular Structure; Oxidation-Reduction; Oxygen / chemistry; Pyridines / chemical synthesis; Pyridines / chemistry; Spectrophotometry, Ultraviolet; Temperature
TL;DR:
The reversible dioxygen reactivity of ((6)L)Fe(II) is described using a combination of low-temperature UV-vis and multinuclear NMR spectroscopies and the coordination of the tethered pyridyl arm to the heme-superoxo complex as axial base ligand is suggested.
(via Semantic Scholar)
Sources: ORCID, Crossref, NC State University Libraries
Added: December 15, 2020
2001 journal article
(F8TPP)FeII/O2 Reactivity Studies {F8TPP = Tetrakis(2,6-difluorophenyl)porphyrinate(2−)}: Spectroscopic (UV−Visible and NMR) and Kinetic Study of Solvent-Dependent (Fe/O2= 1:1 or 2:1) Reversible O2-Reduction and Ferryl Formation
Inorganic Chemistry, 40(23), 5754–5767.
Contributors: * , R. Kretzer*, I. Guzei *, A. Rheingold *, Y. Neuhold*, K. Hatwell*, A. Zuberbühler*, K. Karlin *
MeSH headings : Chemical Phenomena; Chemistry, Physical; Crystallography, X-Ray; Ferrous Compounds / chemistry; Heme / chemistry; Magnetic Resonance Spectroscopy; Metalloporphyrins / chemistry; Microscopy, Ultraviolet; Models, Molecular; Molecular Structure; Oxidation-Reduction; Oxygen / chemistry; Spectrometry, Mass, Fast Atom Bombardment; Spectrophotometry, Ultraviolet; Time Factors
TL;DR:
Stopped-flow UV-visible spectrophotometry studies of the (F(8)TPP)Fe(II) (1)/O(2) reaction in EtCN and THF solvents were able to provide kinetic and thermodynamic insight into the reversible formation of 2.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
6. Clean Water and Sanitation
(OpenAlex)
Sources: ORCID, Crossref, NC State University Libraries
Added: December 15, 2020
2001 journal article
Dioxygen Reactivity of Mononuclear Heme and Copper Components Yielding A High-Spin Heme−Peroxo−Cu Complex
Journal of the American Chemical Society, 123(25), 6183–6184.
Contributors: * , K. Hatwell*, K. Karlin *, H. Huang *, P. Moënne-Loccoz *, C. Krebs *, B. Huynh*, L. Marzilli*
Sources: Crossref, ORCID, NC State University Libraries
Added: August 28, 2020
2000 journal article
Nitric Oxide Reductase from Paracoccus denitrificans Contains an Oxo-Bridged Heme/Non-Heme Diiron Center
Journal of the American Chemical Society, 122(38), 9344–9345.
Contributors: P. Moënne-Loccoz *, O. Richter*, H. Huang *, I. Wasser*, * , K. Karlin *, S. De Vries*
Sources: ORCID, Crossref, NC State University Libraries
Added: December 15, 2020
1999 journal article
Dioxygen Reactivity of Fully Reduced [LFeII···CuI]+Complexes Utilizing Tethered Tetraarylporphyrinates: Active Site Models for Heme-Copper Oxidases
Inorganic Chemistry, 38(10), 2244–2245.
Source: Crossref
Added: January 23, 2021
1999 journal article
Dioxygen reactivity of fully reduced [LFeII⋯CuI]+ complexes utilizing tethered tetraarylporphyrinates: Active site models for heme-copper oxidases
Inorganic Chemistry, 38(10), 2244–2245. http://www.scopus.com/inward/record.url?eid=2-s2.0-0001509852&partnerID=MN8TOARS
Source: ORCID
Added: December 15, 2020
1999 journal article
Formation and Characterization of a High-Spin Heme-Copper Dioxygen (Peroxo) Complex
Journal of the American Chemical Society, 121(42), 9885–9886.
Contributors: * , T. Ju*, D. Lee *, P. Moënne-Loccoz *, S. Kaderli*, Y. Neuhold*, A. Zuberbühler*, A. Woods *, R. Cotter *, K. Karlin *
Sources: ORCID, Crossref, NC State University Libraries
Added: December 15, 2020
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