@article{fogle_hudson_thomson_sherman_gruen_lacelles_colby_clary_longo_meeker_2021, title={Improved neurocognitive performance in FIV infected cats following treatment with the p75 neurotrophin receptor ligand LM11A-31}, volume={27}, ISSN={["1538-2443"]}, DOI={10.1007/s13365-021-00956-2}, abstractNote={HIV rapidly infects the central nervous system (CNS) and establishes a persistent viral reservoir within microglia, perivascular macrophages and astrocytes. Inefficient control of CNS viral replication by antiretroviral therapy results in chronic inflammation and progressive cognitive decline in up to 50% of infected individuals with no effective treatment options. Neurotrophin based therapies have excellent potential to stabilize and repair the nervous system. A novel non-peptide ligand, LM11A-31, that targets the p75 neurotrophin receptor (p75NTR) has been identified as a small bioavailable molecule capable of strong neuroprotection with minimal side effects. To evaluate the neuroprotective effects of LM11A-31 in a natural infection model, we treated cats chronically infected with feline immunodeficiency virus (FIV) with 13 mg/kg LM11A-31 twice daily over a period of 10 weeks and assessed effects on cognitive functions, open field behaviors, activity, sensory thresholds, plasma FIV, cerebrospinal fluid (CSF) FIV, peripheral blood mononuclear cell provirus, CD4 and CD8 cell counts and general physiology. Between 12 and 18 months post-inoculation, cats began to show signs of neural dysfunction in T maze testing and novel object recognition, which were prevented by LM11A-31 treatment. Anxiety-like behavior was reduced in the open field and no changes were seen in sensory thresholds. Systemic FIV titers were unaffected but treated cats exhibited a log drop in CSF FIV titers. No significant adverse effects were observed under all conditions. The data indicate that LM11A-31 is likely to be a potent adjunctive treatment for the control of neurodegeneration in HIV infected individuals.}, number={2}, journal={JOURNAL OF NEUROVIROLOGY}, author={Fogle, Jonathan E. and Hudson, Lola and Thomson, Andrea and Sherman, Barbara and Gruen, Margaret and Lacelles, B. Duncan and Colby, Brenda M. and Clary, Gillian and Longo, Frank and Meeker, Rick B.}, year={2021}, month={Apr}, pages={302–324} }
 @article{kennedy_thomson_griffith_fogle_lascelles_meeker_sherman_gruen_2018, title={Enrichment Preferences of FIV-Infected and Uninfected Laboratory-Housed Cats}, volume={10}, ISSN={1999-4915}, url={http://dx.doi.org/10.3390/v10070353}, DOI={10.3390/v10070353}, abstractNote={Environmental enrichment is critical for alleviating stress in laboratory felines. However, there is a paucity of information about suitable enrichment for cats. This study aimed to determine preferred enrichment options of individually-housed, castrated male domestic short hair cats (Felis catus) used in a longitudinal study of the effects of chronic feline immunodeficiency virus (FIV) infection, and to determine if the FIV status of the cats affected enrichment preferences. Preference testing was performed with two types of grooming brushes, three different interactive play options, including a laser, ball, and petting interaction with a familiar investigator, and two types of toenail conditioning objects. We found that cats elected to be brushed, preferred social interaction and play with the laser to the ball, and preferred to scratch on an inclined-box toenail conditioning object compared to a horizontal, circular toenail conditioning object. There were individual preferences for enrichment opportunities. There were no differences in preferences between FIV-infected and sham-infected cats. These enrichment preferences may be used to advise laboratory animal facilities and researchers about how to best accommodate the behavioral needs of laboratory cats.}, number={7}, journal={Viruses}, publisher={MDPI AG}, author={Kennedy, Claudia and Thomson, Andrea and Griffith, Emily and Fogle, Jonathan and Lascelles, B. and Meeker, Rick and Sherman, Barbara and Gruen, Margaret}, year={2018}, month={Jul}, pages={353} }
 @article{gruen_thomson_clary_hamilton_hudson_meeker_sherman_2013, title={Conditioning laboratory cats to handling and transport}, volume={42}, ISSN={["1548-4475"]}, DOI={10.1038/laban.361}, abstractNote={As research subjects, cats have contributed substantially to our understanding of biological systems, from the development of mammalian visual pathways to the pathophysiology of feline immunodeficiency virus as a model for human immunodeficiency virus. Few studies have evaluated humane methods for managing cats in laboratory animal facilities, however, in order to reduce fear responses and improve their welfare. The authors describe a behavioral protocol used in their laboratory to condition cats to handling and transport. Such behavioral conditioning benefits the welfare of the cats, the safety of animal technicians and the quality of feline research data.}, number={10}, journal={LAB ANIMAL}, author={Gruen, Margaret E. and Thomson, Andrea E. and Clary, Gillian P. and Hamilton, Alexandra K. and Hudson, Lola C. and Meeker, Rick B. and Sherman, Barbara L.}, year={2013}, month={Oct}, pages={385–389} }