Works (21)
Updated: July 19th, 2023 12:40
2021 journal article
Binding specificity and function of the SWI/SNF subunit SMARCA4 bromodomain interaction with acetylated histone
JOURNAL OF BIOLOGICAL CHEMISTRY, 297(4).
co-author countries:
United States of America 🇺🇸
MeSH headings : Acetylation; Animals; Caenorhabditis elegans / genetics; Caenorhabditis elegans / metabolism; Caenorhabditis elegans Proteins / genetics; Caenorhabditis elegans Proteins / metabolism; Histones / genetics; Histones / metabolism; Humans; Protein Binding; Transcription Factors / genetics; Transcription Factors / metabolism
www.jbc.org (publisher PDF)
Sources: ORCID, Web Of Science
Added: August 31, 2021
2021 journal article
Structure, Function, and Thermal Adaptation of the Biotin Carboxylase Domain Dimer from Hydrogenobacter thermophilus 2-Oxoglutarate Carboxylase
BIOCHEMISTRY, 60(4), 324–345.
co-author countries:
United States of America 🇺🇸
MeSH headings : Bacteria / enzymology; Bacterial Proteins / chemistry; Carbon-Nitrogen Ligases / chemistry; Crystallography, X-Ray; Enzyme Stability; Hot Temperature; Protein Domains; Structure-Activity Relationship
Sources: ORCID, Web Of Science
Added: January 20, 2021
2016 journal article
5-Hydroxymethylcytosine in E-box motifs ACAT|GTG and ACAC|GTG increases DNA-binding of the B-HLH transcription factor TCF4
INTEGRATIVE BIOLOGY, 8(9), 936–945.
co-author countries:
France 🇫🇷 United States of America 🇺🇸
MeSH headings : 5-Methylcytosine / analogs & derivatives; 5-Methylcytosine / chemistry; Basic Helix-Loop-Helix Leucine Zipper Transcription Factors / chemistry; Basic Helix-Loop-Helix Leucine Zipper Transcription Factors / ultrastructure; Binding Sites; DNA / chemistry; DNA / ultrastructure; DNA-Binding Proteins / chemistry; DNA-Binding Proteins / ultrastructure; E-Box Elements; Protein Array Analysis / methods; Protein Binding; Protein Interaction Domains and Motifs; Protein Interaction Mapping; Transcription Factor 4 / chemistry; Transcription Factor 4 / ultrastructure
Sources: Web Of Science, ORCID
Added: August 6, 2018
2016 journal article
A High-Resolution Crystal Structure of a Psychrohalophilic alpha-Carbonic Anhydrase from Photobacterium profundum Reveals a Unique Dimer Interface
PLOS ONE, 11(12).
co-author countries:
United States of America 🇺🇸
Ed(s): A. Hofmann
MeSH headings : Carbonic Anhydrases / chemistry; Chlorides / chemistry; Chromatography, Gel; Crystallography, X-Ray; Dimerization; Molecular Dynamics Simulation; Photobacterium / enzymology; Protein Conformation
Sources: ORCID, Web Of Science
Added: August 6, 2018
2016 journal article
Modeling the Growth of Archaeon Halobacterium halobium Affected by Temperature and Light
Applied Biochemistry and Biotechnology, 181(3), 1080–1095.
co-author countries:
United States of America 🇺🇸
author keywords: Halobacterium holobium; Sigmoidal model; Temperature effect; Light intensity effect; Bacteriorhodopsin
MeSH headings : Halobacterium salinarum / growth & development; Hot Temperature; Light; Models, Biological
Sources: Web Of Science, ORCID, Crossref
Added: August 6, 2018
2015 journal article
Evaluation of a DLA-79 allele associated with multiple immune-mediated diseases in dogs
Immunogenetics, 68(3), 205–217.
co-author countries:
United Kingdom of Great Britain and Northern Ireland 🇬🇧 United States of America 🇺🇸
Contributors: S. Friedenberg n, G. Buhrman n, L. Chdid n, N. Olby n , T. Olivry n , J. Guillaumin *, T. O’Toole*, R. Goggs *
author keywords: Canine; Immune-mediated disease; Dog leukocyte antigen; Major histocompatibility complex class Ib
MeSH headings : Alleles; Amino Acid Substitution; Animals; Autoimmune Diseases / genetics; Autoimmune Diseases / immunology; Binding Sites; Dog Diseases / genetics; Dog Diseases / immunology; Dogs; Exons; Gene Frequency; Genetic Predisposition to Disease; Genotype; Histocompatibility Antigens Class I / chemistry; Histocompatibility Antigens Class I / genetics; Histocompatibility Antigens Class I / immunology; Immune System Diseases / veterinary; Meta-Analysis as Topic; Models, Molecular; Peptides / chemistry; Peptides / metabolism; Phenotype; Polymorphism, Single Nucleotide; Protein Conformation; Reproducibility of Results; Structure-Activity Relationship
Sources: Web Of Science, ORCID, Crossref
Added: August 6, 2018
2015 journal article
Interactions with the Bifunctional Interface of the Transcriptional Coactivator DCoH1 Are Kinetically Regulated
JOURNAL OF BIOLOGICAL CHEMISTRY, 290(7), 4319–4329.
co-author countries:
United States of America 🇺🇸
MeSH headings : Animals; Chromatography, Gel; Crystallography, X-Ray; Hydro-Lyases / chemistry; Hydro-Lyases / genetics; Hydro-Lyases / metabolism; Kinetics; Mice; Models, Molecular; Mutation / genetics; Protein Conformation; Protein Folding; Protein Multimerization; Serine / chemistry; Serine / genetics; Serine / metabolism; Threonine / chemistry; Threonine / genetics; Threonine / metabolism; Water / chemistry
Sources: Web Of Science, ORCID
Added: August 6, 2018
2014 journal article
Carboxylation of cytosine (5caC) in the CG dinucleotide in the E-box motif (CGCAG vertical bar GTG) increases binding of the Tcf3 vertical bar Ascl1 helix-loop-helix heterodimer 10-fold
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 449(2), 248–255.
author keywords: Carboxylation; E-Box motif; CG dinucleotide; Basic-helix-loop-helix; DNA binding; Tcf3 vertical bar Ascl1 heterodimer
MeSH headings : 5-Methylcytosine / chemistry; 5-Methylcytosine / metabolism; Amino Acid Sequence; Animals; Base Sequence; Basic Helix-Loop-Helix Transcription Factors / chemistry; Basic Helix-Loop-Helix Transcription Factors / genetics; Basic Helix-Loop-Helix Transcription Factors / metabolism; Circular Dichroism; Cytosine / analogs & derivatives; Cytosine / chemistry; Cytosine / metabolism; Dinucleoside Phosphates / chemistry; Dinucleoside Phosphates / metabolism; E-Box Elements; Humans; Models, Molecular; Molecular Sequence Data; Protein Binding; Protein Multimerization
Sources: Web Of Science, ORCID
Added: August 6, 2018
2013 journal article
Binding Polymorphism in the DNA Bound State of the Pdx1 Homeodomain
PLOS COMPUTATIONAL BIOLOGY, 9(8).
co-author countries:
United States of America 🇺🇸
Sources: Web Of Science, ORCID
Added: August 6, 2018
2012 journal article
A Novel DNA Binding Mechanism for maf Basic Region-Leucine Zipper Factors Inferred from a MafA-DNA Complex Structure and Binding Specificities
BIOCHEMISTRY, 51(48), 9706–9717.
co-author countries:
United States of America 🇺🇸
MeSH headings : Amino Acid Sequence; Base Sequence; Crystallography, X-Ray; DNA / metabolism; DNA Primers; Electrophoretic Mobility Shift Assay; Leucine Zippers; Maf Transcription Factors, Large / chemistry; Maf Transcription Factors, Large / metabolism; Molecular Sequence Data; Protein Binding; Protein Conformation; Sequence Homology, Amino Acid
Sources: Web Of Science, ORCID
Added: August 6, 2018
2010 journal article
Crystallization and preliminary X-ray diffraction analysis of red clover necrotic mosaic virus
ACTA CRYSTALLOGRAPHICA SECTION F-STRUCTURAL BIOLOGY COMMUNICATIONS, 66(Pt 11), 1458–1462.
co-author countries:
United States of America 🇺🇸
Contributors: S. Martin n, R. Guenther n, T. Sit n , P. Swartz n, F. Meilleur n , S. Lommel n, n
author keywords: red clover necrotic mosaic virus; dianthoviruses; viruses
MeSH headings : Crystallization; Crystallography, X-Ray; Microscopy, Electron, Transmission; Tombusviridae / chemistry; Tombusviridae / ultrastructure; Virion / chemistry; Virion / ultrastructure
Sources: Web Of Science, ORCID
Added: August 6, 2018
2010 journal article
Kinetic Stability May Determine the Interaction Dynamics of the Bifunctional Protein DCoH1, the Dimerization Cofactor of the Transcription Factor HNF-1 alpha
BIOCHEMISTRY, 49(47), 10187–10197.
co-author countries:
United States of America 🇺🇸
MeSH headings : Chromatography, Gel; Enzyme Stability; Guanidine / pharmacology; Hepatocyte Nuclear Factor 1-alpha / metabolism; Hydro-Lyases / genetics; Hydro-Lyases / metabolism; Kinetics; Models, Molecular; Point Mutation; Protein Denaturation; Protein Multimerization; Protein Unfolding; Spectrometry, Fluorescence; Tryptophan / chemistry
Sources: Web Of Science, ORCID
Added: August 6, 2018
2010 journal article
X-ray structure of the metcyano form of dehaloperoxidase from Amphitrite ornata: Evidence for photoreductive dissociation of the iron-cyanide bond
Acta Crystallographica. Section D, Biological Crystallography, 66, 770–782.
Source: NC State University Libraries
Added: August 6, 2018
2008 journal article
Crystal structure of E47 neuroD1/Beta2 bHLH domain DNA complex: Heterodimer selectivity and DNA recognition
BIOCHEMISTRY, 47(1), 218–229.
co-author countries:
United States of America 🇺🇸
MeSH headings : Amino Acid Sequence; Animals; Base Sequence; Basic Helix-Loop-Helix Transcription Factors / chemistry; Basic Helix-Loop-Helix Transcription Factors / metabolism; Binding Sites; Crystallography, X-Ray; DNA / chemistry; DNA / genetics; DNA / metabolism; Dimerization; Humans; Mice; Models, Molecular; Molecular Sequence Data; Nerve Tissue Proteins / chemistry; Nerve Tissue Proteins / metabolism; Protein Binding; Protein Structure, Secondary; Protein Structure, Tertiary; Sequence Homology, Amino Acid; TCF Transcription Factors / chemistry; TCF Transcription Factors / metabolism; Transcription Factor 7-Like 1 Protein
Sources: Web Of Science, ORCID
Added: August 6, 2018
2007 journal article
Structural Basis for Induced Fit Mechanisms in DNA Recognition by the Pdx1 Homeodomain†,‡
Biochemistry, 46(11), 2948–2957.
co-author countries:
United States of America 🇺🇸
MeSH headings : Amino Acid Sequence; Animals; Base Sequence; Cricetinae; Crystallization; Crystallography, X-Ray; DNA / metabolism; Homeodomain Proteins / genetics; Homeodomain Proteins / metabolism; Mesocricetus; Models, Molecular; Molecular Sequence Data; Nucleic Acid Conformation; Protein Conformation; Sequence Alignment; Trans-Activators / genetics; Trans-Activators / metabolism
Sources: Crossref, ORCID
Added: February 10, 2020
2007 journal article
Structural basis for induced fit mechanisms in DNA recognition by the Pdx1 homeodomain
Biochemistry, 46(11), 2948–2957.
Sources: NC State University Libraries, ORCID
Added: August 6, 2018
2005 journal article
Structure of the conserved transcriptional repressor enhancer of rudimentary homolog
BIOCHEMISTRY, 44(13), 5017–5023.
co-author countries:
United States of America 🇺🇸
MeSH headings : Amino Acid Sequence; Animals; Binding Sites; Cell Cycle Proteins / chemistry; Cell Cycle Proteins / genetics; Cell Cycle Proteins / metabolism; Conserved Sequence; Crystallography, X-Ray; Dimerization; Evolution, Molecular; Humans; In Vitro Techniques; Models, Molecular; Molecular Sequence Data; Protein Structure, Quaternary; Protein Structure, Secondary; Recombinant Proteins / chemistry; Recombinant Proteins / genetics; Recombinant Proteins / metabolism; Sequence Homology, Amino Acid; Static Electricity; Transcription Factors / chemistry; Transcription Factors / genetics; Transcription Factors / metabolism
Sources: Web Of Science, ORCID
Added: August 6, 2018
2004 journal article
Biochemical and structural basis for partially redundant enzymatic and ranscriptional functions of DCoH and DCoH2
BIOCHEMISTRY, 43(23), 7345–7355.
co-author countries:
United States of America 🇺🇸
MeSH headings : Amino Acid Sequence; Animals; Crystallography, X-Ray; DNA-Binding Proteins / metabolism; Hepatocyte Nuclear Factor 1; Hepatocyte Nuclear Factor 1-alpha; Humans; Hydro-Lyases / chemistry; Hydro-Lyases / genetics; Hydro-Lyases / metabolism; Mice; Models, Molecular; Molecular Sequence Data; Nuclear Proteins / metabolism; Phylogeny; Protein Structure, Tertiary; Pseudogenes / genetics; Sequence Alignment; Transcription Factors / metabolism; Transcription, Genetic
Sources: Web Of Science, ORCID
Added: August 6, 2018
1998 journal article
Domain flexibility in retroviral proteases: structural implications for drug resistant mutations.
Biochemistry.
co-author countries:
United States of America 🇺🇸
MeSH headings : Aspartic Acid Endopeptidases / chemistry; Aspartic Acid Endopeptidases / genetics; Binding Sites / genetics; Catalysis; Dimerization; Drug Resistance, Microbial / genetics; Enzyme Stability; HIV Protease / chemistry; HIV Protease / genetics; HIV Protease Inhibitors / pharmacology; HIV-1 / drug effects; HIV-1 / enzymology; HIV-1 / genetics; Humans; In Vitro Techniques; Ligands; Models, Molecular; Point Mutation; Protease Inhibitors / pharmacology; Protein Conformation; Protein Structure, Secondary; Simian Immunodeficiency Virus / drug effects; Simian Immunodeficiency Virus / enzymology; Simian Immunodeficiency Virus / genetics
Source: ORCID
Added: February 10, 2023
1996 journal article
Three-dimensional structures of HIV-1 and SIV protease product complexes.
Biochemistry.
co-author countries:
United States of America 🇺🇸
MeSH headings : Aspartic Acid / chemistry; Aspartic Acid / metabolism; Aspartic Acid Endopeptidases / chemistry; Aspartic Acid Endopeptidases / genetics; Aspartic Acid Endopeptidases / metabolism; Crystallization; Crystallography, X-Ray; Enzyme Stability; HIV Protease / chemistry; HIV Protease / genetics; HIV Protease / metabolism; Hydrogen Bonding; Ligands; Models, Molecular; Mutagenesis; Oligopeptides / chemical synthesis; Oligopeptides / chemistry; Oligopeptides / metabolism; Protein Conformation
Source: ORCID
Added: February 10, 2023
1993 journal article
Structure of the protease from simian immunodeficiency virus: complex with an irreversible nonpeptide inhibitor.
Biochemistry.
MeSH headings : Aspartic Acid / chemistry; Aspartic Acid Endopeptidases / antagonists & inhibitors; Aspartic Acid Endopeptidases / ultrastructure; Binding Sites; Crystallography, X-Ray; Epoxy Compounds / pharmacology; Nitrophenols / pharmacology; Protein Structure, Secondary; Protein Structure, Tertiary; Recombinant Proteins; Simian Immunodeficiency Virus / enzymology; Water / chemistry
Source: ORCID
Added: February 10, 2023
Employment
Updated: December 13th, 2018 21:45
2002 - present
North Carolina State University Raleigh, NC, US
Associate Professor
Biochemistry
Education
Updated: January 7th, 2019 11:14
1989 - 1996
UCSF Medical Center San Francisco, CA, US
PhD
Biophysics
1977 - 1982
Yale University New Haven, CT, US
BA
physics
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