Works (92)

Updated: April 3rd, 2024 18:02

2023 journal article

C/EBP beta deficiency enhances the keratinocyte innate immune response to direct activators of cytosolic pattern recognition receptors

INNATE IMMUNITY, 29(1-2), 14–24.

By: J. House n, S. Gray n, J. Owen n, D. Jima n, R. Smart n & J. Hall n

author keywords: C/EBP beta; cell death; keratinocytes; type I IFN response
MeSH headings : Animals; Mice; Caspase 3 / metabolism; Caspase 8 / metabolism; CCAAT-Enhancer-Binding Protein-beta / genetics; Immunity, Innate; Interferon Type I / metabolism; Keratinocytes; Receptors, Pattern Recognition / genetics; Receptors, Pattern Recognition / metabolism
TL;DR: The conditional deletion of C/EBPβ transcription factor in mouse epidermis resulted in the upregulation of IFNβ and numerous keratinocyte interferon-stimulated genes (ISGs) and the expression of cytosolic pattern recognition receptors (cPRRs), that recognize viral RNA and DNA, were significantly increased, and enriched in the RNAseq data set. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (Web of Science; OpenAlex)
Sources: Web Of Science, NC State University Libraries
Added: May 30, 2023

2021 journal article

TIN2 is an architectural protein that facilitates TRF2-mediated trans- and cis-interactions on telomeric DNA

NUCLEIC ACIDS RESEARCH, 49(22), 13000–13018.

By: P. Kaur n, R. Barnes*, H. Pan n, A. Detwiler*, M. Liu n, C. Mahn n, J. Hall n, Z. Messenger n ...

MeSH headings : Animals; DNA / chemistry; DNA / genetics; DNA / metabolism; HeLa Cells; Humans; Mice, Inbred C57BL; Microscopy, Atomic Force; Nucleic Acid Conformation; Protein Binding; Shelterin Complex / genetics; Shelterin Complex / metabolism; Telomere / genetics; Telomere / metabolism; Telomere-Binding Proteins / genetics; Telomere-Binding Proteins / metabolism; Telomeric Repeat Binding Protein 2 / genetics; Telomeric Repeat Binding Protein 2 / metabolism
TL;DR: A molecular model in which TIN2 functions as an architectural protein to promote TRF2-mediated trans and cis higher-order nucleic acid structures at telomeres is proposed. (via Semantic Scholar)
Sources: Web Of Science, NC State University Libraries
Added: January 18, 2022

2020 journal article

Measurement of Novel, Drinking Water-Associated PFAS in Blood from Adults and Children in Wilmington, North Carolina

ENVIRONMENTAL HEALTH PERSPECTIVES, 128(7).

By: N. Kotlarz n, J. McCord*, D. Collier*, C. Lea*, M. Strynar*, A. Lindstrom*, A. Wilkie n, J. Islam n ...

MeSH headings : Adult; Alkanesulfonic Acids; Caprylates; Child; Drinking Water; Environmental Exposure / statistics & numerical data; Female; Fluorocarbons / analysis; Fluorocarbons / blood; Humans; Male; North Carolina; Nutrition Surveys; Rivers; Water Pollutants, Chemical / analysis
TL;DR: Poorly understood fluoroethers released into the Cape Fear River by a fluorochemical manufacturing facility were detected in blood samples from Wilmington, North Carolina, residents. (via Semantic Scholar)
UN Sustainable Development Goal Categories
6. Clean Water and Sanitation (Web of Science; OpenAlex)
Sources: Web Of Science, NC State University Libraries
Added: August 24, 2020

2019 journal article

C/EBP beta suppresses keratinocyte autonomous type 1 IFN response and p53 to increase cell survival and susceptibility to UVB-induced skin cancer

CARCINOGENESIS, 40(9), 1099–1109.

By: H. Tam n, J. Hall n, Z. Messenger n, D. Jima n, J. House n, K. Linder n, R. Smart n

Contributors: H. Tam n, J. Hall n, Z. Messenger n, D. Jima n, J. House n, K. Linder n, R. Smart n

TL;DR: A p53-C/E BPβ feedback loop, whereby C/EBPβ a transcriptional target of a p53 pathway, functions as a survival factor by negatively regulating p53 apoptotic activity in response to DNA damage is suggested. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (Web of Science; OpenAlex)
Sources: Web Of Science, NC State University Libraries, ORCID
Added: November 18, 2019

2018 journal article

C/EBPβ deletion in oncogenic Ras skin tumors is a synthetic lethal event

Cell Death & Disease, 9(11).

By: Z. Messenger*, J. Hall*, D. Jima*, J. House*, H. Tam, D. Tokarz*, R. Smart*

Contributors: Z. Messenger*, J. Hall*, D. Jima*, J. House*, H. Tam, D. Tokarz*, R. Smart*

MeSH headings : 9,10-Dimethyl-1,2-benzanthracene / administration & dosage; Animals; Apoptosis / drug effects; Apoptosis / genetics; CCAAT-Enhancer-Binding Protein-beta / deficiency; CCAAT-Enhancer-Binding Protein-beta / genetics; Cell Differentiation; Cell Transformation, Neoplastic / genetics; Cell Transformation, Neoplastic / metabolism; Cell Transformation, Neoplastic / pathology; Gene Expression Regulation, Neoplastic; Genes, Lethal; Keratinocytes / drug effects; Keratinocytes / metabolism; Keratinocytes / pathology; Mice; Mice, Knockout; Receptors, Death Domain / genetics; Receptors, Death Domain / metabolism; Signal Transduction; Skin / drug effects; Skin / metabolism; Skin / pathology; Skin Neoplasms / chemically induced; Skin Neoplasms / genetics; Skin Neoplasms / metabolism; Skin Neoplasms / pathology; Tetradecanoylphorbol Acetate / administration & dosage; Tetradecanoylphorbol Acetate / analogs & derivatives; Tumor Suppressor Protein p53 / genetics; Tumor Suppressor Protein p53 / metabolism; ras Proteins / genetics; ras Proteins / metabolism
TL;DR: The results show that oncogenic Ras tumors display a significant DNA damage/replicative stress phenotype and these tumors have acquired a dependence on C/EBPβ for their survival, making it a promising target for future potential anticancer therapies. (via Semantic Scholar)
Sources: Crossref, NC State University Libraries, Web Of Science, ORCID
Added: October 29, 2018

2018 chapter

Carcinogenesis

In R. C. Smart & E. Hodgson (Eds.), Molecular and Biochemical Toxicology (5th ed.). Hoboken, NJ: J Wiley and Sons.

By: R. Smart & J. Hall

Ed(s): R. Smart & E. Hodgson

Sources: NC State University Libraries, ORCID
Added: May 5, 2022

2018 chapter

Molecular Techniques in the Study of Gene Function

In R. C. Smart & E. Hodgson (Eds.), Molecular and Biochemical Toxicology (5th ed.). Hoboken, NJ: J Wiley and Sons.

By: Y. Tsuji & R. Smart

Ed(s): R. Smart & E. Hodgson

Sources: NC State University Libraries, ORCID
Added: May 5, 2022

2018 book

Molecular and Biochemical Toxicology

(5th ed.). Hoboken, NJ: J. Wiley and Sons.

Robert Smart

Ed(s): R. Smart & E. Hodgson

Source: NC State University Libraries
Added: May 8, 2022

2018 book

Molecular and Biochemical Toxicology

(ed.). J. Wiley and Sons.

Robert Smart

Source: ORCID
Added: May 12, 2022

2018 chapter

Molecular and Biochemical Toxicology: Definition and Scope

In R. C. Smart & E. Hodgson (Eds.), Molecular and Biochemical Toxicology (5th ed.). Hoboken, NJ: J Wiley and Sons.

By: R. Smart & E. Hodgson

Ed(s): R. Smart & E. Hodgson

Sources: NC State University Libraries, ORCID
Added: May 5, 2022

2015 journal article

Long noncoding RNA lincRNA-p21 is the major mediator of UVB-induced and p53-dependent apoptosis in keratinocytes

CELL DEATH & DISEASE, 6.

By: J. Hall n, Z. Messenger n, H. Tam n, S. Phillips*, L. Recio* & R. Smart n

MeSH headings : Animals; Apoptosis / genetics; Apoptosis / radiation effects; Cell Cycle Checkpoints / genetics; Cell Cycle Checkpoints / radiation effects; Cell Line; Cell Proliferation / genetics; Cell Proliferation / radiation effects; DNA Damage / genetics; DNA Damage / radiation effects; Gene Expression Regulation / radiation effects; Humans; Keratinocytes / metabolism; Keratinocytes / pathology; Keratinocytes / radiation effects; Mice; RNA, Long Noncoding / biosynthesis; RNA, Long Noncoding / genetics; Skin / metabolism; Skin / pathology; Skin / radiation effects; Skin Neoplasms / genetics; Skin Neoplasms / pathology; Tumor Suppressor Protein p53 / genetics; Ultraviolet Rays
UN Sustainable Development Goal Categories
3. Good Health and Well-being (Web of Science; OpenAlex)
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018

2014 journal article

C/EBPα regulates CRL4Cdt2-mediated degradation of p21 in response to UVB-induced DNA damage to control the G1/S checkpoint

Cell Cycle, 13(22), 3602–3610.

By: J. Hall n, M. Bereman n, A. Nepomuceno n, E. Thompson n, D. Muddiman n & R. Smart n

author keywords: C/EBP alpha; CRL4(Cdt2); G(1)/S DNA damage checkpoint; keratinocytes; p21
MeSH headings : Animals; CCAAT-Enhancer-Binding Protein-alpha / genetics; CCAAT-Enhancer-Binding Protein-alpha / metabolism; Cell Cycle Checkpoints / genetics; Cell Cycle Checkpoints / radiation effects; Cyclin-Dependent Kinase Inhibitor p21 / metabolism; DNA Damage / genetics; DNA Damage / radiation effects; G1 Phase Cell Cycle Checkpoints / genetics; Keratinocytes / metabolism; Keratinocytes / radiation effects; Mice; Nuclear Proteins / genetics; Nuclear Proteins / metabolism; Proteolysis; Ubiquitin-Protein Ligases / genetics; Ubiquitin-Protein Ligases / metabolism; Ultraviolet Rays; p21-Activated Kinases / genetics; p21-Activated Kinases / metabolism
TL;DR: Findings reveal C/EBPα regulates G1/S cell cycle arrest in response to DNA damage via the control of CRL4Cdt2 mediated degradation of p21. (via Semantic Scholar)
Sources: Web Of Science, NC State University Libraries, Crossref
Added: August 6, 2018

2011 journal article

C/EBP alpha Expression Is Downregulated in Human Nonmelanoma Skin Cancers and Inactivation of C/EBP alpha Confers Susceptibility to UVB-Induced Skin Squamous Cell Carcinomas

JOURNAL OF INVESTIGATIVE DERMATOLOGY, 131(6), 1339–1346.

By: E. Thompson n, S. Zhu n, J. Hall n, J. House n, R. Ranjan n, J. Burr n, Y. He*, D. Owens*, R. Smart n

Contributors: E. Thompson n, S. Zhu n, J. Hall n, J. House n, R. Ranjan n, J. Burr n, Y. He*, D. Owens*, R. Smart n

MeSH headings : Animals; CCAAT-Enhancer-Binding Protein-alpha / analysis; CCAAT-Enhancer-Binding Protein-alpha / physiology; Carcinoma, Squamous Cell / chemistry; Carcinoma, Squamous Cell / etiology; Cell Cycle; Cells, Cultured; Genes, p53; Humans; Keratosis, Actinic / metabolism; Male; Mice; Mice, Hairless; Mice, Inbred C57BL; Mutation; Neoplasms, Radiation-Induced / etiology; Precancerous Conditions / chemistry; Skin / metabolism; Skin / radiation effects; Skin Neoplasms / chemistry; Skin Neoplasms / etiology; Ultraviolet Rays / adverse effects
TL;DR: It is observed that C/EBPα is induced in normal human epidermal keratinocytes and in the epidermis of human subjects exposed to UVB radiation, and loss of C/ EBPα confers susceptibility toUVB-induced skin SCCs involving defective cell cycle arrest in response to UVBs. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (Web of Science; OpenAlex)
Sources: Web Of Science, NC State University Libraries, ORCID
Added: August 6, 2018

2011 journal article

CD34 antigen: Determination of specific sites of phosphorylation in vitro and in vivo

INTERNATIONAL JOURNAL OF MASS SPECTROMETRY, 301(1-3), 12–21.

By: L. Deterding*, J. Williams*, M. Humble*, R. Petrovich*, S. Wei*, C. Trempus*, M. Gates*, F. Zhu n ...

author keywords: CD34; Phosphorylation; PKC kinase; AKT2 kinase; LC/MS/MS
TL;DR: The identification of the in vitro sites of phosphorylation on the intracellular domain of mouse CD34 following PKC treatment suggests that other kinases, as well as PKC, may have important signaling functions in CD34. (via Semantic Scholar)
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018

2011 journal article

Control of skin cancer by the circadian rhythm

Proceedings of the National Academy of Sciences, 108(46), 18790–18795.

By: S. Gaddameedhi*, C. Selby, W. Kaufmann*, R. Smart n & A. Sancar*

Contributors: S. Gaddameedhi*, C. Selby, W. Kaufmann*, R. Smart n & A. Sancar*

author keywords: circadian clock; cryptochrome; sunbathing; tanning salons
MeSH headings : Animals; Carcinoma, Squamous Cell / etiology; Carcinoma, Squamous Cell / physiopathology; Circadian Rhythm / physiology; DNA Damage; DNA Repair; Disease Models, Animal; Humans; Immunohistochemistry / methods; Mice; Mice, Inbred C57BL; Mice, Transgenic; Skin / radiation effects; Skin Neoplasms / etiology; Skin Neoplasms / physiopathology; Sunlight; Time Factors; Xeroderma Pigmentosum Group A Protein / biosynthesis; Xeroderma Pigmentosum Group A Protein / genetics
TL;DR: It is concluded that time of day of exposure to UVR is a contributing factor to its carcinogenicity in mice, and possibly in humans. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (Web of Science; OpenAlex)
Sources: Crossref, NC State University Libraries, ORCID
Added: February 24, 2020

2011 journal article

PTEN Positively Regulates UVB-Induced DNA Damage Repair

CANCER RESEARCH, 71(15), 5287–5295.

By: M. Ming n, L. Feng n, C. Shea n, K. Soltani n, B. Zhao n, W. Han n, R. Smart n, C. Trempus n, Y. He n

MeSH headings : Animals; Carcinoma, Squamous Cell / etiology; Carcinoma, Squamous Cell / genetics; Carcinoma, Squamous Cell / pathology; Cell Line / metabolism; Cell Line / pathology; Cell Line / radiation effects; Checkpoint Kinase 1; Checkpoint Kinase 2; DNA Damage; DNA Repair / genetics; DNA Repair / physiology; DNA-Binding Proteins / physiology; Down-Regulation; Humans; Keratinocytes / metabolism; Keratinocytes / pathology; Keratinocytes / radiation effects; Keratosis, Actinic / genetics; Keratosis, Actinic / pathology; Mice; Neoplasms, Radiation-Induced / genetics; Neoplasms, Radiation-Induced / pathology; PTEN Phosphohydrolase / antagonists & inhibitors; PTEN Phosphohydrolase / deficiency; PTEN Phosphohydrolase / genetics; PTEN Phosphohydrolase / physiology; Papilloma / etiology; Papilloma / genetics; Papilloma / pathology; Precancerous Conditions / etiology; Precancerous Conditions / genetics; Protein Kinases / physiology; Protein Serine-Threonine Kinases / physiology; Proto-Oncogene Proteins c-akt / physiology; RNA, Small Interfering / pharmacology; Skin Neoplasms / etiology; Skin Neoplasms / genetics; Skin Neoplasms / pathology; Ultraviolet Rays / adverse effects; p38 Mitogen-Activated Protein Kinases / antagonists & inhibitors
TL;DR: This work shows that attenuating PTEN in epidermal keratinocytes is a predisposing factor for UVB-induced skin carcinogenesis in mice, and defines PTEN as an essential genomic gatekeeper in the skin through its ability to positively regulate XPC-dependent GG-NER following DNA damage. (via Semantic Scholar)
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018

2010 journal article

Ablation of TAK1 Upregulates Reactive Oxygen Species and Selectively Kills Tumor Cells

Cancer Research, 70(21), 8417–8425.

By: E. Omori n, K. Matsumoto n, S. Zhu n, R. Smart n & J. Ninomiya-Tsuji n

MeSH headings : 9,10-Dimethyl-1,2-benzanthracene / toxicity; Animals; Apoptosis; Blotting, Western; Carcinogens / toxicity; Cell Proliferation; Gene Deletion; Integrases / metabolism; Keratinocytes / cytology; Keratinocytes / drug effects; Keratinocytes / metabolism; MAP Kinase Kinase Kinases / antagonists & inhibitors; MAP Kinase Kinase Kinases / physiology; Mice; Mice, Knockout; Papilloma / chemically induced; Papilloma / metabolism; Papilloma / pathology; RNA, Messenger / genetics; RNA, Small Interfering / pharmacology; Reactive Oxygen Species / metabolism; Reverse Transcriptase Polymerase Chain Reaction; Skin / metabolism; Skin / pathology; Skin Neoplasms / chemically induced; Skin Neoplasms / metabolism; Skin Neoplasms / pathology; Up-Regulation
TL;DR: TAK1 kinase could be a new and effective molecular target for ROS-based tumor killing and is examined whether ablation of TAK1 in preexisting skin tumors could cause an increase in ROS and result in tumor cell death. (via Semantic Scholar)
Sources: Crossref, NC State University Libraries, Web Of Science
Added: August 6, 2018

2010 journal article

C/EBP alpha and C/EBP beta Are Required for Sebocyte Differentiation and Stratified Squamous Differentiation in Adult Mouse Skin

PLOS ONE, 5(3).

By: J. House n, S. Zhu n, R. Ranjan n, K. Linder n & R. Smart n

Contributors: J. House n, S. Zhu n, R. Ranjan n, K. Linder n & R. Smart n

MeSH headings : Animals; CCAAT-Enhancer-Binding Protein-alpha / physiology; CCAAT-Enhancer-Binding Protein-beta / physiology; Cell Cycle; Cell Differentiation; Cell Proliferation; Epithelial Cells / cytology; Gene Expression Regulation; Genotype; Homozygote; Immunoblotting; Immunohistochemistry / methods; Keratinocytes / cytology; Mice; Sebaceous Glands / cytology; Skin / cytology
TL;DR: Results indicate that in adult mouse skin, C/EBPα and C-EBPβ are critically involved in regulating sebocyte differentiation and epidermal homeostasis involving the basal to spinous keratinocyte transition and basal cell cycle withdrawal. (via Semantic Scholar)
Sources: Web Of Science, NC State University Libraries, ORCID
Added: August 6, 2018

2010 chapter

Chemical Carcinogenesis and Mutagenesis

In E. Hodgson (Ed.), Modern Toxicology (4th ed.). New York: J. Wiley and Sons.

By: R. Smart

Ed(s): E. Hodgson

Sources: NC State University Libraries, ORCID
Added: May 5, 2022

2010 journal article

Overexpression of Transcription Factor Sp2 Inhibits Epidermal Differentiation and Increases Susceptibility to Wound- and Carcinogen-Induced Tumorigenesis

CANCER RESEARCH, 70(21), 8507–8516.

By: T. Kim n, S. Chiera n, K. Linder n, C. Trempus n, R. Smart n & J. Horowitz n

MeSH headings : 9,10-Dimethyl-1,2-benzanthracene / toxicity; Animals; Blotting, Western; COS Cells; Carcinogens / toxicity; Carcinoma, Squamous Cell / etiology; Carcinoma, Squamous Cell / metabolism; Carcinoma, Squamous Cell / pathology; Cattle; Cell Differentiation; Chlorocebus aethiops; Disease Susceptibility; Epidermal Cells; Epidermis / drug effects; Epidermis / metabolism; Female; Humans; Immunoenzyme Techniques; Keratin-5 / genetics; Keratinocytes / cytology; Keratinocytes / drug effects; Keratinocytes / metabolism; Male; Mice; Mice, Transgenic; Promoter Regions, Genetic; RNA, Messenger / genetics; Reverse Transcriptase Polymerase Chain Reaction; Skin Neoplasms / etiology; Skin Neoplasms / metabolism; Skin Neoplasms / pathology; Sp2 Transcription Factor / physiology; Wounds and Injuries
TL;DR: It is reported that Sp2 protein abundance in mice increases in concert with the progression of carcinogen-induced murine squamous cell carcinomas, and this results directly support the likelihood that Sp2 overexpression occurring in various human cancers has significant functional effect. (via Semantic Scholar)
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018

2010 journal article

RSK-Mediated Phosphorylation in the C/EBP beta Leucine Zipper Regulates DNA Binding, Dimerization, and Growth Arrest Activity

MOLECULAR AND CELLULAR BIOLOGY, 30(11), 2621–2635.

By: S. Lee, J. Shuman, T. Guszczynski*, K. Sakchaisri, T. Sebastian, T. Copeland*, M. Miller*, M. Cohen* ...

MeSH headings : Amino Acid Sequence; Animals; CCAAT-Enhancer-Binding Protein-beta / chemistry; CCAAT-Enhancer-Binding Protein-beta / genetics; CCAAT-Enhancer-Binding Protein-beta / metabolism; Cell Cycle / physiology; Cell Line; DNA / genetics; DNA / metabolism; Growth Substances / metabolism; Humans; Leucine Zippers; MAP Kinase Signaling System / physiology; Mice; Mitogen-Activated Protein Kinases / antagonists & inhibitors; Mitogen-Activated Protein Kinases / genetics; Mitogen-Activated Protein Kinases / metabolism; Molecular Sequence Data; Phosphorylation; Protein Multimerization; Protein Processing, Post-Translational; Rats; Ribosomal Protein S6 Kinases / antagonists & inhibitors; Ribosomal Protein S6 Kinases / genetics; Ribosomal Protein S6 Kinases / metabolism; Sequence Alignment; Transcriptional Activation; ras Proteins / genetics; ras Proteins / metabolism
TL;DR: It is shown that C/EBPβ DNA binding is autorepressed and becomes activated by the Ras-Raf-MEK-ERK-p90RSK cascade and RSK-mediated phosphorylation of a bifunctional residue in the leucine zipper that regulates DNA binding and homodimerization and thereby promotes cell cycle arrest. (via Semantic Scholar)
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018

2009 journal article

C/EBP alpha expression is partially regulated by C/EBP beta in response to DNA damage and C/EBP alpha-deficient fibroblasts display an impaired G(1) checkpoint

ONCOGENE, 28(36), 3235–3245.

By: R. Ranjan n, E. Thompson n, K. Yoon* & R. Smart n

author keywords: C/EBP; DNA damage response; G(1)/S transition; p53
MeSH headings : Animals; Blotting, Western; CCAAT-Enhancer-Binding Protein-alpha / genetics; CCAAT-Enhancer-Binding Protein-alpha / metabolism; CCAAT-Enhancer-Binding Protein-beta / genetics; CCAAT-Enhancer-Binding Protein-beta / metabolism; DNA Damage; Female; Fibroblasts / drug effects; Fibroblasts / metabolism; Fibroblasts / radiation effects; Flow Cytometry; G1 Phase; Gene Expression; Male; Methylnitronitrosoguanidine / toxicity; Mice; Mice, Inbred C57BL; Mice, Inbred Strains; Mice, Knockout; Reverse Transcriptase Polymerase Chain Reaction; S Phase; Time Factors; Ultraviolet Rays
TL;DR: This study shows a novel function for C/EBPβ in the regulation of C/N′-nitro-N-nitrosoguanidine-treated fibroblasts and provides definitive genetic evidence that C-EBPα has a critical role in the DNA damage G1 checkpoint. (via Semantic Scholar)
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018

2008 journal article

C/EBP beta represses p53 to promote cell survival downstream of DNA damage independent of oncogenic Ras and p19(Arf)

CELL DEATH AND DIFFERENTIATION, 15(11), 1734–1744.

By: S. Ewing n, S. Zhu n, F. Zhu n, J. House n & R. Smart n

Contributors: S. Ewing n, S. Zhu n, F. Zhu n, J. House n & R. Smart n

author keywords: apoptosis; p53; C/EBP beta; p19(Arf); DNA damage; keratinocytes
MeSH headings : Animals; Apoptosis / drug effects; CCAAT-Enhancer-Binding Protein-beta / deficiency; CCAAT-Enhancer-Binding Protein-beta / metabolism; Carcinogens / toxicity; Cell Survival / drug effects; Cyclin-Dependent Kinase Inhibitor p16 / metabolism; Cyclophosphamide / administration & dosage; Cyclophosphamide / pharmacology; DNA Damage; Epidermal Cells; Epidermis / drug effects; Epidermis / metabolism; Injections, Intraperitoneal; Keratinocytes / cytology; Keratinocytes / drug effects; Keratinocytes / metabolism; Mice; Oncogene Protein p21(ras) / metabolism; Protein Processing, Post-Translational / drug effects; Repressor Proteins / metabolism; Transcriptional Activation / drug effects; Tumor Suppressor Protein p53 / genetics; Tumor Suppressor Protein p53 / metabolism
TL;DR: Results suggest that inhibition of C/EBPβ may be a target for cancer cotherapy to increase the efficacy of alkylating chemotherapeutic agents and suggest that p19Arf represses p53 to promote cell survival downstream of DNA damage. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (Web of Science; OpenAlex)
Sources: Web Of Science, NC State University Libraries, ORCID
Added: August 6, 2018

2008 chapter

Carcinogenesis

In Molecular and Biochemical Toxicology (4th ed., pp. 537–586).

By: R. Smart n, S. Ewing* & K. Loomis n

Sources: Crossref, NC State University Libraries
Added: April 9, 2022

2008 book

Molecular and Biochemical Toxicology

Robert Smart

Ed(s): R. Smart & E. Hodgson

TL;DR: This crucial new edition has been completely revised to provide timely and thorough coverage of the underlying biochemical, molecular, and cellular mechanisms through which toxicants produce their adverse effects. (via Semantic Scholar)
Sources: Crossref, NC State University Libraries
Added: April 10, 2022

2008 chapter

Molecular and Biochemical Toxicology: Definition and Scope

In R. C. Smart & E. Hodgson (Eds.), Molecular and Biochemical Toxicology (4th ed., pp. 1–4).

By: E. Hodgson n & R. Smart n

Ed(s): R. Smart n & E. Hodgson n

Sources: Crossref, NC State University Libraries
Added: April 9, 2022

2008 chapter

Overview of Molecular Techniques in Toxicology: Genes and Transgenes

In R. C. Smart & E. Hodgson (Eds.), Molecular and Biochemical Toxicology (4th ed., pp. 5–24).

By: R. Smart n

Ed(s): R. Smart n & E. Hodgson

UN Sustainable Development Goal Categories
4. Quality Education (OpenAlex)
Sources: Crossref, NC State University Libraries
Added: April 9, 2022

2007 journal article

Decreased survival of C/EBP beta-deficient keratinocytes is due to aberrant regulation of p53 levels and function

ONCOGENE, 26(3), 360–367.

By: K. Yoon n, S. Zhu n, S. Ewing n & R. Smart n

author keywords: apoptosis; p53; C/EBP beta; keratinocytes
MeSH headings : 9,10-Dimethyl-1,2-benzanthracene / toxicity; Animals; Apoptosis; CCAAT-Enhancer-Binding Protein-beta / genetics; CCAAT-Enhancer-Binding Protein-beta / physiology; Carcinogens / toxicity; Cell Survival; Epidermis / drug effects; Epidermis / metabolism; Epidermis / pathology; Female; Gene Expression Regulation, Neoplastic; Immunoenzyme Techniques; In Situ Nick-End Labeling; Keratinocytes / drug effects; Keratinocytes / metabolism; Keratinocytes / pathology; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; Proto-Oncogene Proteins c-bcl-2 / metabolism; Proto-Oncogene Proteins c-mdm2 / metabolism; Proto-Oncogene Proteins p21(ras) / metabolism; Reverse Transcriptase Polymerase Chain Reaction; Tumor Suppressor Protein p53 / genetics; Tumor Suppressor Protein p53 / metabolism
TL;DR: The results demonstrate that altered keratinocyte survival in C/EBPβ−/− mice results from aberrant regulation of p53 protein and function and indicate C/ EBPβ has a role in the negative regulation ofp53 protein levels in response to carcinogen-induced stress. (via Semantic Scholar)
UN Sustainable Development Goal Categories
2. Zero Hunger (OpenAlex)
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018

2007 journal article

Genetic ablation of CCAAT/Enhancer binding protein alpha in epidermis reveals its role in suppression of epithelial tumorigenesis

CANCER RESEARCH, 67(14), 6768–6776.

By: K. Loomis n, S. Zhu*, K. Yoon*, P. Johnson* & R. Smart n

MeSH headings : Animals; Apoptosis; CCAAT-Enhancer-Binding Protein-alpha / genetics; Cell Differentiation; Cell Proliferation; Epidermis / metabolism; Epithelial Cells / metabolism; Gene Expression Regulation, Neoplastic; Keratinocytes / cytology; Mice; Mice, Inbred BALB C; Mice, Knockout; Mutation; NIH 3T3 Cells; ras Proteins / metabolism
TL;DR: C/EBPalpha is dispensable for epidermal homeostasis and provides genetic evidence that C/EB Palpha is a suppressor of epithelial tumorigenesis, as well as proposed to block cell cycle progression through inhibition of E2F activity. (via Semantic Scholar)
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018

2006 journal article

Conditional ablation of C/EBP beta demonstrates its keratinocyte-specific requirement for cell survival and mouse skin tumorigenesis

ONCOGENE, 25(8), 1272–1276.

By: E. Sterneck*, S. Zhu n, A. Ramirez*, J. Jorcano* & R. Smart*

author keywords: C/EBP; apoptosis; carcinogenesis
MeSH headings : 9,10-Dimethyl-1,2-benzanthracene / toxicity; Animals; Apoptosis; CCAAT-Enhancer-Binding Protein-beta / genetics; CCAAT-Enhancer-Binding Protein-beta / physiology; Carcinogens / toxicity; Female; Integrases / metabolism; Keratin-15; Keratin-5; Keratinocytes / metabolism; Keratinocytes / pathology; Keratins / genetics; Mice; Mice, Inbred C57BL; Mice, Knockout; Promoter Regions, Genetic; Skin Neoplasms / chemically induced; Skin Neoplasms / metabolism; Skin Neoplasms / pathology; Tetradecanoylphorbol Acetate / toxicity
TL;DR: It is demonstrated that C/EBPβ exerts an essential, keratinocyte-intrinsic role in cell survival in response to carcinogen treatment and the elimination of C/ EBPβ in keratinocytes is sufficient to confer complete resistance of the skin to chemical carcinogenesis. (via Semantic Scholar)
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018

2006 journal article

TAK1 is a master regulator of epidermal homeostasis involving skin inflammation and apoptosis

JOURNAL OF BIOLOGICAL CHEMISTRY, 281(28), 19610–19617.

MeSH headings : Animals; Apoptosis; Cytokines / metabolism; Epidermis / metabolism; Gene Deletion; Homeostasis; Inflammation; Keratinocytes / cytology; Keratinocytes / metabolism; MAP Kinase Kinase 4 / metabolism; MAP Kinase Kinase Kinases / physiology; Mice; Mice, Inbred C57BL; NF-kappa B / metabolism; Skin / pathology
TL;DR: It is demonstrated that TAK1 is the major regulator of skin inflammation as well as keratinocyte death in vivo and is a master regulator of TNF signaling in skin and regulates skin inflammation and keratinocytes death. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (Web of Science; OpenAlex)
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018

2005 journal article

Diminished expression of C/EBP alpha in skin carcinomas is linked to oncogenic Ras and reexpression of C/EBP alpha in carcinoma cells inhibits proliferation

Cancer Research, 65(3), 861–867.

By: M. Shim, K. Powers, S. Ewing, S. Zhu & R. Smart

Sources: NC State University Libraries, ORCID
Added: August 6, 2018

2004 journal article

C/EBP alpha is a DNA damage-inducible p53-regulated mediator of the G(1) checkpoint in keratinocytes

MOLECULAR AND CELLULAR BIOLOGY, 24(24), 10650–10660.

By: K. Yoon n & R. Smart n

MeSH headings : Animals; Blotting, Western; CCAAT-Enhancer-Binding Protein-alpha / metabolism; Caspases / analysis; Cell Line; Cells, Cultured; DNA Damage; Dose-Response Relationship, Radiation; Electrophoretic Mobility Shift Assay; Fibroblasts / drug effects; Fibroblasts / metabolism; Fibroblasts / radiation effects; G1 Phase; Humans; Immunohistochemistry; Keratinocytes / drug effects; Keratinocytes / metabolism; Keratinocytes / pathology; Keratinocytes / radiation effects; Kinetics; Methylnitronitrosoguanidine / pharmacology; Mice; Mice, Inbred C57BL; Mice, Inbred Strains; Mutagens / pharmacology; NIH 3T3 Cells; Precipitin Tests; Rats; Retroviridae / genetics; Skin / metabolism; Time Factors; Tumor Suppressor Protein p53 / deficiency; Tumor Suppressor Protein p53 / metabolism; Ultraviolet Rays
TL;DR: A novel role is uncovered for C/EBPα as a p53-regulated DNA damage-inducible gene that has a critical function in the DNA damage G1 checkpoint response in keratinocytes. (via Semantic Scholar)
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018

2004 journal article

Cell cycle-dependent phosphorylation of C/EBP beta mediates oncogenic cooperativity between C/EBP beta and H-Ras(V12)

MOLECULAR AND CELLULAR BIOLOGY, 24(17), 7380–7391.

By: J. Shuman*, T. Sebastian*, P. Kaldis*, T. Copeland*, S. Zhu n, R. Smart n, P. Johnson*

MeSH headings : Amino Acid Sequence; Animals; CCAAT-Enhancer-Binding Protein-beta / genetics; CCAAT-Enhancer-Binding Protein-beta / metabolism; CDC2-CDC28 Kinases / metabolism; Cell Cycle / physiology; Cell Transformation, Neoplastic; Cyclin-Dependent Kinase 2; Enzyme Inhibitors / metabolism; Genes, ras; Mice; Mitogen-Activated Protein Kinases / genetics; Mitogen-Activated Protein Kinases / metabolism; Molecular Sequence Data; NIH 3T3 Cells; Phosphorylation; Proto-Oncogene Proteins c-raf / genetics; Proto-Oncogene Proteins c-raf / metabolism; Sequence Alignment; Serine / metabolism; Signal Transduction; Threonine / metabolism; ras Proteins / genetics; ras Proteins / metabolism
TL;DR: It is shown that cell cycle-dependent phosphorylation of C/EBPβ on Ser64 and Thr189 is required to promote Ras-induced transformation of NIH 3T3 cells, and this support a role for C/ EBPβ as a nuclear effector of Ras signaling and transformation. (via Semantic Scholar)
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018

2004 chapter

Chemical Carcinogenesis

In E. Hodgson (Ed.), A Textbook of Modern Toxicology (pp. 225–250).

By: R. Smart n

Ed(s): E. Hodgson

UN Sustainable Development Goal Categories
3. Good Health and Well-being (OpenAlex)
Sources: Crossref, NC State University Libraries
Added: April 9, 2022

2004 chapter

Introduction to Biochemical and Molecular Methods in Toxicology

In E. Hodgson (Ed.), A Textbook of Modern Toxicology (pp. 13–22).

By: E. Hodgson n, G. Leblanc n, S. Meyer* & R. Smart n

Ed(s): E. Hodgson n

Sources: Crossref, NC State University Libraries
Added: December 8, 2019

2003 journal article

Lithium stabilizes the CCAAT/enhancer-binding protein alpha (C/EBP alpha) through a glycogen synthase kinase 3 (GSK3)-independent pathway involving direct inhibition of proteasomal activity

JOURNAL OF BIOLOGICAL CHEMISTRY, 278(22), 19674–19681.

By: M. Shim n & R. Smart n

MeSH headings : Animals; CCAAT-Enhancer-Binding Protein-alpha / genetics; CCAAT-Enhancer-Binding Protein-alpha / metabolism; Cell Line; Cysteine Endopeptidases; Glycogen Synthase Kinases / genetics; Glycogen Synthase Kinases / metabolism; Lithium / pharmacology; Mice; Mice, Inbred BALB C; Multienzyme Complexes / antagonists & inhibitors; Mutagenesis, Site-Directed; Proteasome Endopeptidase Complex; Ubiquitin / metabolism
TL;DR: Results demonstrate C/EBPα is degraded via a ubiquitin-dependent proteasomal pathway, and LiCl stabilizes C/ EBPα through a GSK3-independent pathway involving direct inhibition of proteasome activity. (via Semantic Scholar)
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018

2003 patent

Method of treating alopecia

Washington, DC: U.S. Patent and Trademark Office.

By: R. Smart & H. Oh

Source: NC State University Libraries
Added: August 6, 2018

2003 article

Method of treating alopecia

(Vol. 6, 555, 532). Vol. 6, 555, 532. Washington, DC: U.S. Patent and Trademark Office.

By: R. Smart & H. Oh

Source: ORCID
Added: May 12, 2022

2002 journal article

17 beta-estradiol is a hormonal regulator of mirex tumor promotion sensitivity in mice

TOXICOLOGICAL SCIENCES, 69(1), 42–48.

By: K. Porter*, S. Chanda, H. Wang, K. Gaido, R. Smart & C. Robinette

author keywords: mirex; skin; 17 beta-estradiol; tumor promotion; endocrine
MeSH headings : Animals; Carcinogens / toxicity; Cell Line; Chlordecone / toxicity; Drug Implants; Estradiol / administration & dosage; Estradiol / pharmacology; Female; Genes, Reporter / drug effects; Insecticides / toxicity; Luciferases / biosynthesis; Male; Mice; Mirex / toxicity; Orchiectomy; Ovariectomy; Radioimmunoassay; Sex Characteristics
TL;DR: Collectively, these studies indicate that E2 is a major ovarian hormone responsible for mirex tumor promotion sensitivity in female mice. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (OpenAlex)
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018

2002 journal article

CCAAT/enhancer binding protein-beta is a mediator of keratinocyte survival and skin tumorigenesis involving oncogenic Ras signaling

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 99(1), 207–212.

By: S. Zhu n, K. Yoon n, E. Sterneck n, P. Johnson n & R. Smart n

MeSH headings : 3T3 Cells; 9,10-Dimethyl-1,2-benzanthracene; Animals; Apoptosis; Blotting, Western; Bromodeoxyuridine / pharmacology; CCAAT-Enhancer-Binding Protein-beta / genetics; CCAAT-Enhancer-Binding Protein-beta / metabolism; CCAAT-Enhancer-Binding Protein-beta / physiology; Carcinogens; Cell Division; Cell Survival; Genes, Reporter; Keratinocytes / cytology; Keratinocytes / metabolism; Mice; Mice, Inbred BALB C; Mice, Transgenic; Mitogen-Activated Protein Kinase 1 / metabolism; Mitogen-Activated Protein Kinase 3; Mitogen-Activated Protein Kinases / metabolism; Mutagens; Mutation; Oncogene Protein p21(ras) / genetics; Oncogene Protein p21(ras) / physiology; Phosphorylation; Signal Transduction; Skin Neoplasms / metabolism; Tetradecanoylphorbol Acetate; Time Factors; Transcriptional Activation
TL;DR: It is reported here that C/EBPβ-nullizygous mice are completely refractory to skin tumor development induced by a variety of carcinogens and carcinogenesis protocols, including 7,12-dimethylbenz[a]anthracene-initiation/12-O-tetradecanoylphorbol 13-acetate promotion, that produce tumors containing oncogenic Ras mutations. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (Web of Science; OpenAlex)
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018

2002 journal article

Deficiency of either cyclooxygenase (COX)-1 or COX-2 alters epidermal differentiation and reduces mouse skin tumorigenesis

Cancer Research, 62(12), 3395–3401.

By: H. Tiano, C. Loftin, J. Akunda, C. Lee, J. Spalding, A. Sessoms, D. Dunson, E. Rogan ...

Sources: NC State University Libraries, ORCID
Added: August 6, 2018

2001 chapter

Biochemical Toxicology: Definition and Scope

In E. Hodgson & R. C. Smart (Eds.), Introduction to Biochemical Toxicology (pp. 1–10). New York: J. Wiley and Sons.

By: E. Hodgson & R. Smart

Ed(s): E. Hodgson & R. Smart

Sources: NC State University Libraries, ORCID
Added: May 5, 2022

2001 chapter

Carcinogenesis

In E. Hodgson & R. C. Smart (Eds.), Introduction to Biochemical Toxicology (3rd ed., pp. 343–398). New York: J. Wiley and Sons.

By: R. Smart & J. Akunda

Ed(s): E. Hodgson & R. Smart

Sources: NC State University Libraries, ORCID
Added: May 5, 2022

2001 book

Introduction to Biochemical Toxicology

(3rd ed.). New York: J. Wiley and Sons.

Robert Smart

Ed(s): E. Hodgson & R. Smart

Source: NC State University Libraries
Added: May 8, 2022

2001 book

Introduction to Biochemical Toxicology

(ed.). J. Wiley and Sons.

Robert Smart

Source: ORCID
Added: May 12, 2022

2001 patent

Method of treating alopecia

Washington, DC: U.S. Patent and Trademark Office.

By: R. Smart & H. Oh

Source: NC State University Libraries
Added: August 6, 2018

2001 article

Method of treating alopecia

(Vol. 6, 204, 258). Vol. 6, 204, 258. Washington, DC: U.S. Patent and Trademark Office.

By: R. Smart & H. Oh

Source: ORCID
Added: May 12, 2022

2001 chapter

Molecular Techniques in Toxicology

In E. Hodgson & R. C. Smart (Eds.), Introduction to Biochemical Toxicology (3rd ed., pp. 11–32). New York: J. Wiley and Sons.

By: R. Smart

Ed(s): E. Hodgson & R. Smart

Sources: NC State University Libraries, ORCID
Added: May 5, 2022

2001 journal article

Protein kinase C-alpha coordinately regulates cytosolic phospholipase A(2) activity and the expression of cyclooxygenase-2 through different mechanisms in mouse keratinocytes

MOLECULAR PHARMACOLOGY, 59(4), 860–866.

By: H. Wang n, M. Kim n, H. Tiano n, R. Langenbach n & R. Smart n

MeSH headings : Animals; Arachidonic Acid / metabolism; CCAAT-Enhancer-Binding Protein-beta / metabolism; Cells, Cultured; Cyclooxygenase 2; Cytosol / enzymology; Dinoprostone / metabolism; Enzyme Inhibitors / pharmacology; Inflammation / metabolism; Isoenzymes / antagonists & inhibitors; Isoenzymes / biosynthesis; Isoenzymes / genetics; Isoenzymes / metabolism; Keratinocytes / cytology; Keratinocytes / drug effects; Keratinocytes / metabolism; Keratins / genetics; Mice; Mice, Transgenic; Mitogen-Activated Protein Kinase Kinases / antagonists & inhibitors; Phospholipases A / metabolism; Phospholipids / metabolism; Phosphorylation / drug effects; Promoter Regions, Genetic; Prostaglandin-Endoperoxide Synthases / biosynthesis; Protein Isoforms / genetics; Protein Kinase C / antagonists & inhibitors; Protein Kinase C / genetics; Protein Kinase C / metabolism; Protein Kinase C-alpha; Signal Transduction / drug effects; Signal Transduction / physiology; Skin / drug effects; Skin / metabolism; Tetradecanoylphorbol Acetate / pharmacology
TL;DR: It is indicated that epidermal PKC alpha coordinately regulates cPLA(2) activity and COX-2 expression resulting in increased levels of AA and PGE(2), and MEK-dependent and C/EBP beta-independent events. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018

2000 journal article

17 beta-Estradiol and ICI-182780 regulate the hair follicle cycle in mice through an estrogen receptor-alpha pathway

AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM, 278(2), E202–E210.

By: S. Chanda*, C. Robinette n, J. Couse* & R. Smart*

author keywords: skin; hair growth; hormones; androgens
MeSH headings : Administration, Topical; Animals; Blotting, Northern; Dose-Response Relationship, Drug; Estradiol / administration & dosage; Estradiol / analogs & derivatives; Estradiol / pharmacology; Estrogen Antagonists / administration & dosage; Estrogen Antagonists / pharmacology; Estrogen Receptor alpha; Female; Fulvestrant; Hair / growth & development; Hair Follicle / drug effects; Hair Follicle / physiology; Immunohistochemistry; Mice; Ovariectomy; RNA, Messenger / analysis; Receptors, Estrogen / drug effects; Receptors, Estrogen / genetics; Receptors, Estrogen / physiology; Skin / drug effects; Skin / metabolism
TL;DR: Findings implicate a skin-specific ER-alpha pathway in the regulation of the hair follicle cycle and indicate the direct rather than secondary systemic nature of their effects. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018

1999 journal article

A multihit, multistage model of chemical carcinogenesis

CARCINOGENESIS, 20(9), 1837–1844.

By: D. Owens, S. Wei* & R. Smart*

MeSH headings : 9,10-Dimethyl-1,2-benzanthracene / toxicity; Acetone / toxicity; Animals; Carcinogens / toxicity; Carcinoma, Squamous Cell / chemically induced; Carcinoma, Squamous Cell / pathology; Cell Transformation, Neoplastic / chemically induced; Cell Transformation, Neoplastic / genetics; Cocarcinogenesis; DNA Mutational Analysis; DNA, Neoplasm / genetics; Female; Gene Expression Regulation, Neoplastic; Genes, ras; Keratinocytes / drug effects; Keratinocytes / pathology; Keratins / biosynthesis; Keratins / genetics; Mice; Models, Biological; Neoplasm Proteins / biosynthesis; Neoplasm Proteins / genetics; Papilloma / chemically induced; Papilloma / pathology; Polymerase Chain Reaction; Polymorphism, Single-Stranded Conformational; S Phase; Skin Neoplasms / chemically induced; Skin Neoplasms / pathology; Tetradecanoylphorbol Acetate / toxicity
TL;DR: Promotion between the first and second hits has a profound outcome on carcinogenesis, presumably by increasing the probability that a second hit will occur in a previously initiated cell; continued promotion after the second hit is required for full expression of malignancy; and the classic initiation-promotion protocol can be extended to a multihit, multistage model. (via Semantic Scholar)
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018

1999 journal article

C/EBP beta modulates the early events of keratinocyte differentiation involving growth arrest and keratin 1 and keratin 10 expression

Molecular and Cellular Biology, 19(10), 7181–7190.

By: S. Zhu n, H. Oh n, M. Shim n, E. Sterneck*, P. Johnson* & R. Smart n

MeSH headings : Animals; CCAAT-Enhancer-Binding Proteins; Calcium Signaling; Cell Differentiation; Cell Division; Cells, Cultured; DNA-Binding Proteins / metabolism; Epidermal Cells; Keratin-10; Keratinocytes / cytology; Keratins / biosynthesis; Membrane Proteins / biosynthesis; Mice; Mice, Mutant Strains; Nuclear Proteins / metabolism; Protein Precursors / biosynthesis; Transcriptional Activation
TL;DR: It is demonstrated that C/EBPβ plays an important role in the early events of stratified squamous differentiation in keratinocytes involving growth arrest and K1 and K10 expression and expression of later-stage markers was only minimally altered. (via Semantic Scholar)
Sources: NC State University Libraries, NC State University Libraries
Added: August 6, 2018

1999 journal article

Correlation between expression of peroxisome proliferator-activated receptor beta and squamous differentiation in epidermal and tracheobronchial epithelial cells

MOLECULAR AND CELLULAR ENDOCRINOLOGY, 147(1-2), 85–92.

By: H. Matsuura*, H. Adachi*, R. Smart n, X. Xu*, J. Arata* & A. Jetten*

author keywords: peroxisome proliferator-activated receptor; epidermis; keratinocyte; trachea; phorbol ester; retinoic acid; transglutaminase
MeSH headings : Animals; Bronchi / cytology; Cell Differentiation / drug effects; Cell Line; Cornified Envelope Proline-Rich Proteins; Epidermal Cells; Epidermis / drug effects; Epidermis / metabolism; Epithelial Cells / cytology; Epithelial Cells / drug effects; Epithelial Cells / metabolism; Female; Humans; Interferon-gamma / pharmacology; Keratinocytes / cytology; Keratinocytes / drug effects; Keratinocytes / metabolism; Membrane Proteins / genetics; Mice; Mice, Inbred Strains; RNA, Messenger / metabolism; Receptors, Cytoplasmic and Nuclear / genetics; Tetradecanoylphorbol Acetate / pharmacology; Time Factors; Trachea / cytology; Transcription Factors / genetics; Transcriptional Activation / drug effects; Transforming Growth Factor beta / pharmacology; Transglutaminases / genetics; Tretinoin / pharmacology
TL;DR: The results demonstrate that the expression of PPARbeta is associated with squamous differentiation suggesting a regulatory role for this receptor in the control of specific genes during this differentiation process. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018

1999 article

Effects of 17-beta-estradiol and ICI 182 780 on hair growth in various strains of mice

Smart, R. C., Oh, H. S., Chanda, S., & Robinette, C. L. (1999, December). JOURNAL OF INVESTIGATIVE DERMATOLOGY SYMPOSIUM PROCEEDINGS, Vol. 4, pp. 285–289.

By: R. Smart n, H. Oh n, S. Chanda n & C. Robinette n

author keywords: alopecia; dermal papilla; estrogen receptor; hair follicle
MeSH headings : Administration, Topical; Animals; Estradiol / administration & dosage; Estradiol / analogs & derivatives; Estrogen Antagonists / administration & dosage; Female; Fulvestrant; Hair / drug effects; Hair / growth & development; Male; Mice; Mice, Inbred C3H; Mice, Inbred C57BL
TL;DR: The results demonstrate that (i) the route of administration of 17-beta-estradiol is critical for its ability to block hair growth, and (ii) C57BL/6 and C3H mice, two commonly employed mouse strains for hair growth studies, responded to 17- beta-ESTradiol and ICI 182 780 in a manner similar to that described in CD-1 mice. (via Semantic Scholar)
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018

1999 patent

Methods of treating alopecia

Washington, DC: U.S. Patent and Trademark Office.

By: R. Smart & H. Oh

Source: NC State University Libraries
Added: August 6, 2018

1999 article

Methods of treating alopecia

(Vol. 5, 965, 551). Vol. 5, 965, 551. Washington, DC: U.S. Patent and Trademark Office.

By: R. Smart & H. Oh

Source: ORCID
Added: May 12, 2022

1999 journal article

Overexpression of protein kinase C-[alpha] in the epidermis of transgenic mice results in striking alterations in phorbol ester-induced inflammation and COX-2, MIP-2, and TNF-[alpha] but not tumor promotion

Journal of Cell Science, 112(20), 3497–3506.

By: H. Wang & R. Smart

Sources: NC State University Libraries, ORCID
Added: August 6, 2018

1998 journal article

Expression of CCAAT/enhancer binding proteins (C/EBP) is associated with squamous differentiation in epidermis and isolated primary keratinocytes and is altered in neoplasms

JOURNAL OF INVESTIGATIVE DERMATOLOGY, 110(6), 939–945.

By: H. Oh n & R. Smart n

author keywords: cytokines; skin; transcription factor
MeSH headings : Animals; CCAAT-Enhancer-Binding Proteins; Calcium / administration & dosage; Calcium / pharmacology; Carcinoma, Squamous Cell / chemistry; Carcinoma, Squamous Cell / metabolism; Cell Differentiation / drug effects; Cell Differentiation / genetics; Cell Differentiation / physiology; DNA-Binding Proteins / analysis; DNA-Binding Proteins / genetics; DNA-Binding Proteins / physiology; Dose-Response Relationship, Drug; Extracellular Space / chemistry; Female; Gene Expression / drug effects; Gene Expression / genetics; Immunohistochemistry; Keratinocytes / chemistry; Keratinocytes / cytology; Keratinocytes / metabolism; Mice; Nuclear Proteins / analysis; Nuclear Proteins / genetics; Nuclear Proteins / physiology; Pregnancy; Skin / chemistry; Skin / metabolism; Skin / ultrastructure; Skin Neoplasms / chemistry; Skin Neoplasms / metabolism; Subcellular Fractions / chemistry; Transcription Factors / analysis; Transcription Factors / genetics; Transcription Factors / physiology
TL;DR: Results implicate a role for the C/EBP family in the regulation of genes involved in or specifically expressed during the process of squamous differentiation in epidermis. (via Semantic Scholar)
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018

1998 personal communication

On the effect of estrogen receptor agonists and antagonists on the mouse hair follicle cycle

Smart, R. C., & Oh, H. S. (1998, July).

By: R. Smart* & H. Oh*

MeSH headings : Animals; Estradiol / analogs & derivatives; Estradiol / pharmacology; Estrogen Antagonists / pharmacology; Fulvestrant; Hair Follicle / drug effects; Hair Follicle / physiology; Mice; Mice, Inbred C3H; Mice, Inbred C57BL; Receptors, Estrogen / physiology
UN Sustainable Development Goal Categories
2. Zero Hunger (OpenAlex)
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018

1997 journal article

Evidence that mirex promotes a unique population of epidermal cells that cannot be distinguished by their mutant Ha ras genotype

Molecular Carcinogenesis, 20(1), 115–124.

By: T. Kim n, K. Porter n, J. Foley*, R. Maronpot* & R. Smart n

TL;DR: The results suggest that mirex may have highly specific effects on the proliferation of initiated cells and support the existence of a unique mirez mechanism and/or distinct population of mireX‐promotable mutant Ha‐ras epidermal cells. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (Web of Science; OpenAlex)
Sources: NC State University Libraries, NC State University Libraries
Added: August 6, 2018

1996 journal article

An estrogen receptor pathway regulates the telogen-anagen hair follicle transition and influences epidermal cell proliferation.

Proceedings of the National Academy of Sciences, 93(22), 12525–12530.

By: H. Oh n & R. Smart n

author keywords: epidermis; estrogen; keratinocyte; differentiation; mesenchymal epithelial interactions
MeSH headings : Animals; Antineoplastic Agents / pharmacology; Bromodeoxyuridine / metabolism; Cell Differentiation; Cell Division; Epidermal Cells; Epidermis / metabolism; Estradiol / analogs & derivatives; Estradiol / metabolism; Estradiol / pharmacology; Estrogen Antagonists / pharmacology; Female; Fulvestrant; Hair Follicle / growth & development; Kinetics; Mice; Receptors, Estrogen / physiology
TL;DR: Findings indicate an estrogen receptor pathway within the dermal papilla regulates the telogen-anagen follicle transition and suggest that diffusible factors associated with the anagen follicles influence cell proliferation in the epidermis. (via Semantic Scholar)
Sources: Crossref, NC State University Libraries
Added: April 10, 2022

1996 journal article

Epidermal Protein Kinase C-β2 Is Highly Sensitive to Downregulation and Is Exclusively Expressed in Langerhans Cells: Downregulation Is Associated with Attenuated Contact Hypersensitivity

Journal of Investigative Dermatology, 107(3), 354–359.

By: A. Goodell n, H. Oh, S. Meyer & R. Smart*

author keywords: skin; epidermis; protein kinase C; keratinocyte
MeSH headings : Animals; Dermatitis, Contact / metabolism; Dermatitis, Contact / physiopathology; Diglycerides / pharmacology; Down-Regulation; Epidermis / enzymology; Female; Immunohistochemistry; Isoenzymes / metabolism; Langerhans Cells / drug effects; Langerhans Cells / enzymology; Mice; Mice, Inbred Strains; Protein Kinase C / metabolism; Protein Kinase C beta; Protein Kinase C-alpha; Tetradecanoylphorbol Acetate / pharmacology
TL;DR: Within the epidermis, PKC-beta 2 is highly sensitive to downregulation and is exclusively expressed in LCs, and the downregulation of PKC - beta 2 is associated with impaired LC function with respect to contact hypersensitivity. (via Semantic Scholar)
Sources: Crossref, NC State University Libraries
Added: April 9, 2022

1996 journal article

Localization and Expression of Cornifin-α/SPRR1 in Mouse Epidermis, Anagen Follicles, and Skin Neoplasms

Journal of Investigative Dermatology, 106(4), 647–654.

By: D. Owens n, A. Jetten, R. Smart* & T. Zainal

author keywords: heratinocytes; cornified envelope; cornifin; SPRR
MeSH headings : Animals; Carcinoma, Squamous Cell / chemically induced; Carcinoma, Squamous Cell / chemistry; Cornified Envelope Proline-Rich Proteins; Epidermis / chemistry; Female; Hair Follicle / chemistry; Immunohistochemistry; Membrane Proteins / analysis; Membrane Proteins / genetics; Mice; Mirex / pharmacology; Papilloma / chemically induced; Papilloma / chemistry; Proteins / analysis; Proteins / genetics; RNA, Messenger / analysis; Skin Neoplasms / chemistry; Tetradecanoylphorbol Acetate / pharmacology
TL;DR: Data indicate that cornifin- α /SPRR1 is expressed in mouse skin and is localized to specific areas of the anagen hair follicle with weak staining in the telogen follicle and epidermis and papillomas and squamous cell carcinomas demonstrate a constitutive increase. (via Semantic Scholar)
Sources: Crossref, NC State University Libraries
Added: April 10, 2022

1995 journal article

Genetic alterations cooperate with v-Ha-ras to accelerate multistage carcinogenesis in TG.AC transgenic mouse skin

Cancer Research, 55(14), 3171–3178.

By: D. Owens, J. Spalding, R. Tennant & R. Smart

Sources: NC State University Libraries, ORCID
Added: May 5, 2022

1995 journal article

Lack of effect of retinoic acid and fluocinolone acetonide on mirex tumor promotion indicates a novel mirex mechanism

Carcinogenesis, 16(9), 2199–2204.

By: T. Kim n & R. Smart n

MeSH headings : 9,10-Dimethyl-1,2-benzanthracene / toxicity; Animals; Anticarcinogenic Agents / therapeutic use; Base Sequence; Carcinogens / toxicity; Cell Division / drug effects; Drug Interactions; Ear, External / drug effects; Edema / chemically induced; Edema / drug therapy; Female; Fluocinolone Acetonide / therapeutic use; Genes, ras / drug effects; Genotype; Mice; Mice, Inbred Strains; Mirex / antagonists & inhibitors; Mirex / toxicity; Molecular Sequence Data; Papilloma / chemically induced; Papilloma / prevention & control; Skin Neoplasms / chemically induced; Skin Neoplasms / prevention & control; Tetradecanoylphorbol Acetate / toxicity; Tretinoin / therapeutic use
TL;DR: Results indicate that the promotional activity of mirex, as well as its weak proliferative response, result from a distinct promoter mechanism and/or that mireX promotes a unique population of epidermal cells that are insensitive to FA and RA and cannot be distinguished by their mutant Ha-ras genotype. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Sources: Crossref, NC State University Libraries
Added: April 9, 2022

1994 journal article

SYNERGISTIC INTERACTION BETWEEN THE NONPHORBOL ESTER-TYPE PROMOTER MIREX AND 12-O-TETRADECANOYLPHORBOL-13-ACETATE IN MOUSE SKIN TUMOR PROMOTION

CARCINOGENESIS, 15(1), 47–52.

By: S. Meyer*, T. Kim, G. Moser, N. Monteiroriviere & R. Smart*

Contributors: S. Meyer*, T. Kim, G. Moser, N. Monteiroriviere & R. Smart*

MeSH headings : Adenine / physiology; Animals; Base Sequence; Carcinogens / toxicity; Dose-Response Relationship, Drug; Drug Synergism; Female; Genes, ras / drug effects; Genes, ras / genetics; Mice; Mice, Inbred Strains; Mirex / toxicity; Molecular Sequence Data; Mutation / drug effects; Mutation / genetics; Papilloma / chemically induced; Papilloma / genetics; Skin / drug effects; Skin Neoplasms / chemically induced; Skin Neoplasms / genetics; Tetradecanoylphorbol Acetate / toxicity; Thymidine / genetics
TL;DR: Epidermal DNA synthesis induced by 2 nmol TPA was potentiated by mirex, further supporting a role for mireX in potentiation of epidermal TPA activity. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Sources: Web Of Science, NC State University Libraries, ORCID
Added: August 6, 2018

1993 chapter

Carcinogenesis

In E. Hodgson & P. E. Levi (Eds.), Biochemical Toxicology (2nd ed., pp. 381–414). Norwalk, CT: Appleton and Lange.

By: R. Smart

Ed(s): E. Hodgson & P. Levi

Sources: NC State University Libraries, ORCID
Added: May 5, 2022

1993 journal article

Characterization of benzo[<i>a</i>]pyrene-initiated mouse skin papillomas for Ha-<i>ras</i> mutations and protein kinase C levels

Carcinogenesis, 14(11), 2289–2295.

By: A. Colapietro n, A. Goodell n & R. Smart n

MeSH headings : 9,10-Dimethyl-1,2-benzanthracene / toxicity; Alleles; Animals; Base Sequence; Benzo(a)pyrene / toxicity; Codon / genetics; DNA, Neoplasm / genetics; DNA, Neoplasm / isolation & purification; Epidermis / drug effects; Epidermis / enzymology; Epidermis / pathology; Female; Genes, ras; Isoenzymes / metabolism; Mice; Mice, Inbred Strains; Molecular Sequence Data; Oligodeoxyribonucleotides; Papilloma / chemically induced; Papilloma / enzymology; Papilloma / genetics; Point Mutation; Protein Kinase C / metabolism; Skin / drug effects; Skin / enzymology; Skin / pathology; Skin Neoplasms / chemically induced; Skin Neoplasms / enzymology; Skin Neoplasms / genetics; Tetradecanoylphorbol Acetate / toxicity
TL;DR: It is found that total PKC activity, as well as PKC alpha and beta 2 isoforms, were markedly decreased in B[a]P-initiated early emergence papillomas and that this decrease was also accompanied by an altered subcellular distribution ofPKC activity. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Sources: Crossref, NC State University Libraries
Added: April 10, 2022

1993 journal article

Characterization of skin tumor promotion by mirex: structure-activity relationships, sexual dimorphism and presence of Ha-<i>ras</i> mutation

Carcinogenesis, 14(6), 1155–1160.

By: G. Moser n, C. Robinette n & R. Smart n

MeSH headings : 9,10-Dimethyl-1,2-benzanthracene; Animals; Body Weight / drug effects; Cocarcinogenesis; DNA Mutational Analysis; Female; Genes, ras / drug effects; Liver / anatomy & histology; Male; Mice; Mirex / toxicity; Mutation; Organ Size / drug effects; Papilloma / chemically induced; Sex Characteristics; Skin Neoplasms / chemically induced; Structure-Activity Relationship
TL;DR: The data indicate that the tumor-promoting ability of mirex is highly structure specific, and ovarian hormones are a factor in the increased sensitivity of female mice to the skin tumor- Promoted ability ofmirex. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Sources: Crossref, NC State University Libraries
Added: April 10, 2022

1993 journal article

Diacylglycerol is an effector of the clonal expansion of cells containing activated Ha-<i>ras</i> genes

Carcinogenesis, 14(12), 2645–2648.

By: K. Mills n, S. Reynolds* & R. Smart*

MeSH headings : 9,10-Dimethyl-1,2-benzanthracene; Adenine; Animals; Base Sequence; Clone Cells; Decanoic Acids / pharmacology; Diglycerides / physiology; Genes, ras; Mice; Mice, Transgenic; Molecular Sequence Data; Mutation; Oligodeoxyribonucleotides; Papilloma / chemically induced; Papilloma / genetics; Second Messenger Systems; Skin Neoplasms / chemically induced; Skin Neoplasms / genetics; Tetradecanoylphorbol Acetate; Thymine
TL;DR: It is reported that 11/12 of DMBA-initiated/DIC10-promoted papillomas examined contain an A-->T mutation in the 61st codon of the Ha-ras gene, suggesting that DAGs affect the clonal expansion of activated Ha- Bras-ras-containing cells. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Sources: Crossref, NC State University Libraries
Added: April 10, 2022

1993 article

MINIMAL ROLE OF ENHANCED CELL-PROLIFERATION IN SKIN TUMOR PROMOTION BY MIREX - A NONPHORBOL ESTER-TYPE PROMOTER

MEYER, S. A., MOSER, G. J., MONTEIRORIVIERE, N. A., & SMART, R. C. (1993, December). ENVIRONMENTAL HEALTH PERSPECTIVES, Vol. 101, pp. 265–269.

By: S. Meyer*, G. Moser, N. Monteiroriviere & R. Smart*

Contributors: S. Meyer*, G. Moser, N. Monteiroriviere & R. Smart*

Sources: Web Of Science, NC State University Libraries, ORCID
Added: August 6, 2018

1992 journal article

Alterations in protein kinase C isozymes α and β<sup>2</sup> in activated Ha-<i>ras</i> containing papillomas in the absence of an increase in diacyiglycerol

Carcinogenesis, 13(7), 1113–1120.

By: K. Mills n, S. Bocckino, D. Burns, C. Loomis & R. Smart n

MeSH headings : 9,10-Dimethyl-1,2-benzanthracene / toxicity; Amino Acid Sequence; Animals; Codon / genetics; Diglycerides / metabolism; Female; Genes, ras; Immune Sera; Isoenzymes / analysis; Isoenzymes / metabolism; Mice; Mice, Inbred Strains; Molecular Sequence Data; Mutation; Papilloma / chemically induced; Papilloma / enzymology; Papilloma / genetics; Peptides / chemical synthesis; Peptides / immunology; Protein Kinase C / analysis; Protein Kinase C / metabolism; Skin / drug effects; Skin / enzymology; Skin Neoplasms / chemically induced; Skin Neoplasms / enzymology; Skin Neoplasms / genetics; Tetradecanoylphorbol Acetate / toxicity
TL;DR: An irreversible decrease in and alteration of the subcellular distribution of PKC-alpha and beta 2 in DMBA-initiated/TPA-promoted papillomas is demonstrated, and occur in the absence of an elevation in the total pool of endogenous DAG. (via Semantic Scholar)
Sources: Crossref, NC State University Libraries
Added: April 10, 2022

1992 journal article

The chlorinated pesticide, mirex is a novel non-phorbol ester tumor promoter in mouse skin

Cancer Research, 52(3), 631–636.

By: G. Moser, S. Meyer & R. Smart

Sources: NC State University Libraries, ORCID
Added: May 5, 2022

1991 journal article

EFFECT OF ASCORBIC-ACID AND ITS SYNTHETIC LIPOPHILIC DERIVATIVE ASCORBYL PALMITATE ON PHORBOL ESTER INDUCED SKIN-TUMOR PROMOTION IN MICE

AMERICAN JOURNAL OF CLINICAL NUTRITION, 54(6), S1266–S1273.

By: R. Smart n & C. Crawford n

author keywords: MULTISTAGE CARCINOGENESIS; VITAMIN-C; ANTI-CARCINOGENS; DIET
MeSH headings : Animals; Ascorbic Acid / administration & dosage; Ascorbic Acid / analogs & derivatives; Ascorbic Acid / pharmacokinetics; Ascorbic Acid / pharmacology; DNA / biosynthesis; Diet; Epidermis / metabolism; Female; Mice; Mice, Inbred Strains; Ornithine Decarboxylase / metabolism; Osmolar Concentration; Skin Neoplasms / chemically induced; Skin Neoplasms / metabolism; Tetradecanoylphorbol Acetate
TL;DR: Preliminary data suggest that the mice not receiving AA developed increased epidermal AA levels in response to the tumor promoting regimen, and it is found that dietary AP inhibited TPA-induced biochemical parameters associated with tumor promotion. (via Semantic Scholar)
UN Sustainable Development Goal Categories
6. Clean Water and Sanitation (OpenAlex)
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018

1991 chapter

Pesticides, tumor promotion and risk assessment in Pesticides and the Future: Toxicological Studies of Risks and Benefits

In E. Hodgson, R. M. Roe, & N. Motoyama (Eds.), Reviews in Pesticides I (pp. 349–357).

By: R. Smart & G. Moser

Ed(s): E. Hodgson, R. Roe & N. Motoyama

Sources: NC State University Libraries, ORCID
Added: May 5, 2022

1990 journal article

Differential down-regulation of epidermal protein kinase C (PKC) by tetradecanoylphorbol-13-acetate and diacylglycerol: Association with epidermal hyperplasia and tumor promotion

Cancer Research, 50, 5740–5745.

By: L. Hansen, N. Monteiro-Riviere & R. Smart

Sources: NC State University Libraries, ORCID
Added: August 6, 2018

1989 journal article

Comparison of epidermal protein kinase C activity, ornithine decarboxylase induction and DNA synthesis stimulated by TPA or dioctanoylglycerol in mouse strains with differing susceptibility to TPA-induced tumor promotion

Carcinogenesis, 10(5), 833–838.

By: K. Mills n & R. Smart n

MeSH headings : Animals; Brain / drug effects; Brain / metabolism; DNA Replication / drug effects; Diglycerides / pharmacology; Enzyme Induction; Female; Glycerides / pharmacology; Kinetics; Mice; Mice, Inbred C57BL; Mice, Inbred DBA; Mice, Inbred Strains; Ornithine Decarboxylase / biosynthesis; Protein Kinase C / metabolism; Skin / drug effects; Skin / metabolism; Species Specificity; Tetradecanoylphorbol Acetate / pharmacology
TL;DR: The level of epidermal PKC activity in CD-1, DBA/2 and C57BL/6 mice exhibit no strain differences when stimulated by TPA or DiC8 using lysine-rich histone as a phosphate acceptor substrate, and the resistant strain demonstrated a 'hyperinducibility' of epidersmal ODC activity by T PA or Di C8. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Sources: Crossref, NC State University Libraries
Added: April 9, 2022

1989 journal article

Hepatic tumor-promoting chlorinated hydrocarbons stimulate protein kinase C activity

Carcinogenesis, 10(5), 851–856.

By: G. Moser n & R. Smart n

MeSH headings : Animals; Brain / enzymology; Calcium / pharmacology; Carcinogens; Chlordan / pharmacology; Female; Hydrocarbons, Fluorinated / pharmacology; Liver / enzymology; Liver Neoplasms / chemically induced; Mice; Protein Kinase C / metabolism; Skin / enzymology; Tetradecanoylphorbol Acetate / pharmacology
TL;DR: It is demonstrated that a wide variety of chlorinated hydrocarbons, which are considered hepatic tumor promoters, stimulate protein kinase C activity in vitro and chlordane was the most potent organochlorine pesticide. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Sources: Crossref, NC State University Libraries
Added: April 10, 2022

1989 journal article

Synthetic lipid second messenger, sn-1,2-didecanoylglycerol: A complete tumor promoter in mouse skin

Cancer Research, 49(16), 4455–4458.

By: R. Smart, K. Mills, L. Hansen & A. Conney

Sources: NC State University Libraries, ORCID
Added: May 5, 2022

1988 journal article

COMPARISON OF THE EFFECT OF SN-1,2-DIDECANOYLGLYCEROL AND 12-O-TETRADECANOYLPHORBOL-13-ACETATE ON CUTANEOUS MORPHOLOGY, INFLAMMATION AND TUMOR PROMOTION IN CD-1 MICE

CARCINOGENESIS, 9(12), 2221–2226.

By: R. Smart n, M. Huang*, N. Monteiroriviere, C. Wong*, K. Mills & A. Conney*

Contributors: R. Smart n, M. Huang*, N. Monteiroriviere, C. Wong*, K. Mills & A. Conney*

MeSH headings : Animals; Carcinogens; Diglycerides / toxicity; Edema / chemically induced; Enzyme Induction; Female; Glycerides / toxicity; Hyperplasia / chemically induced; Mice; Ornithine Decarboxylase / biosynthesis; Skin / drug effects; Skin / enzymology; Skin / pathology; Skin Neoplasms / chemically induced; Tetradecanoylphorbol Acetate / toxicity
TL;DR: It was determined that topical application of 2.5 or 10 mumol of sn-1,2-didecanoylglycerol induced epidermal ornithine decarboxylase activity to about the same extent as the application of 1 or 2 nmol of TPA, but it did not cause morphological changes in the epidermis when applied once or when applied twice a week for 4 weeks and did not function as a complete tumor promoter. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Sources: Web Of Science, NC State University Libraries, ORCID
Added: August 6, 2018

1988 journal article

Inhibitory effect of curcumin, chlorogenic acid, caffeic acid, and ferulic acid on tumor promotion in mouse skin by 12-o-tetradecanoylphorbol-13-acetate

Cancer Research, 48(21), 5941–5946.

By: M. Huang, R. Smart, C. Wong & A. Conney

Sources: NC State University Libraries, ORCID
Added: August 6, 2018

1987 journal article

Ascorbic Acid, Alcohol, and Environmental Chemicals

Annals of the New York Academy of Sciences, 498(1 Third Confere), 364–388.

By: V. Zannoni*, J. Brodfuehrer*, R. Smart* & R. Susick*

MeSH headings : Animals; Ascorbic Acid / physiology; Electron Transport; Environmental Pollutants / metabolism; Ethanol / metabolism; Inactivation, Metabolic; Liver / metabolism; Protein Binding
TL;DR: It is apparent through the efforts of a number of investigators that ascorbic acid is involved in the metabolism and detoxification of numerous xenobiotics, and its participation at a variety of levels warrants further investigation. (via Semantic Scholar)
Sources: Crossref, NC State University Libraries
Added: April 9, 2022

1987 journal article

Characterization of purified DT-diaphorase from liver cytosol of 3-methylcholanthrene-treated rats

Chemica Scripta, 27A:49-54.

By: M. Huang, R. Smart, P. Thomas, C. Pickett & Y. Lu

Sources: NC State University Libraries, ORCID
Added: May 5, 2022

1987 journal article

Inhibition of 12-O-Tetradecanoylphorbol-13-acetate Induction of Ornithine Decarboxylase Activity, DNA Synthesis, and Tumor Promotion in Mouse Skin by Ascorbic Acid and Ascorbyl Palmitate

Cancer Research, 47(24, Part 1), 6633–6638.

By: R. Smart, M. Huang, Z. Han, M. Kaplan, A. Focella & A. Conney

Sources: NC State University Libraries, ORCID
Added: May 5, 2022

1986 journal article

Disposition of the naturally occurring antimutagenic plant phenol, ellagic acid, and its synthetic derivatives, 3-<i>O</i>-decylellagic acid and 3, 3'-di-<i>O</i>-methylellagic acid in mice

Carcinogenesis, 7(10), 1663–1667.

By: R. Smart*, M. Huang, R. Chang, J. Sayer*, D. Jerina* & A. Conney

MeSH headings : 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide / toxicity; Animals; Antineoplastic Agents / metabolism; Benzopyrans / metabolism; Ellagic Acid / analogs & derivatives; Ellagic Acid / metabolism; Ellagic Acid / pharmacology; Feces / analysis; Female; Injections, Intraperitoneal; Injections, Intravenous; Liver / metabolism; Lung / metabolism; Mice; Mutation
TL;DR: The effect of ellagic acid and some of its more lipophilic derivatives on the mutagenicity of (+/-)-7 beta,8 alpha-dihydroxy-9 alpha,10 alpha-epoxy-7,8,9,10-tetrahydrobenz[a]pyrene was examined in Salmonella typhimurium TA100. (via Semantic Scholar)
Sources: Crossref, NC State University Libraries
Added: April 10, 2022

1986 journal article

Effect of dietary ascorbate on covalent binding of benzene to bone marrow and hepatic tissue in vivo

Biochemical Pharmacology, 35(18), 3180–3182.

By: R. Smart* & V. Zannoni*

MeSH headings : Animals; Ascorbic Acid / administration & dosage; Ascorbic Acid / pharmacology; Benzene / metabolism; Bone Marrow / drug effects; Bone Marrow / metabolism; Diet; Guinea Pigs; Liver / drug effects; Liver / metabolism; Male
Sources: Crossref, NC State University Libraries
Added: April 9, 2022

1986 journal article

Effect of ellagic acid and 3-<i>O</i>-decylellagic acid on the formation of benzo[<i>a</i>]pyrene-derived DNA adducts <i>in vivo</i> and on the tumorigenicity of 3-methylcholanthrene in mice

Carcinogenesis, 7(10), 1669–1675.

By: R. Smart*, M. Huang, R. Chang, J. Sayer*, D. Jerina*, A. Wood, A. Conney

MeSH headings : Animals; Antineoplastic Agents / pharmacology; Benzo(a)pyrene / metabolism; Benzopyrans / pharmacology; DNA / metabolism; Dose-Response Relationship, Drug; Ellagic Acid / pharmacology; Female; Lung / metabolism; Methylcholanthrene; Mice; Mice, Inbred BALB C; Skin / metabolism; Skin Neoplasms / chemically induced; Skin Neoplasms / prevention & control; Time Factors; Tritium
TL;DR: Ellagic acid and 3-O-decylellagic acid are not effective in inhibiting [3H]B[a]P DNA adduct formation in mouse skin and lung and that ellagic acid does not inhibit 3-MC-induced skin tumorigenesis in BALB/c or CD-1 mice. (via Semantic Scholar)
Sources: Crossref, NC State University Libraries
Added: April 10, 2022

1986 journal article

sn-l, 2-Diacylglycerols mimic the effects of 12-<i>0</i>-tetradecanoylphorbol-13-acetate <i>in vivo</i> by inducing biochemical changes associated with tumor promotion in mouse epidermis

Carcinogenesis, 7(11), 1865–1870.

By: R. Smart*, M. Huang & A. Conney

MeSH headings : Animals; DNA / biosynthesis; Diglycerides / toxicity; Female; Glycerides / toxicity; Mice; Mice, Inbred Strains; Ornithine Decarboxylase / biosynthesis; Protein Kinase C / analysis; Skin / drug effects; Skin / metabolism; Skin Neoplasms / chemically induced; Tetradecanoylphorbol Acetate
TL;DR: Several sn-1,2-diacylglycerols mimic TPA in vivo with respect to their effects on certain biochemical parameters associated with tumor promotion in mouse skin, and these effects are determined by measuring the incorporation of [3H]thymidine into epidermal DNA. (via Semantic Scholar)
Sources: Crossref, NC State University Libraries
Added: April 10, 2022

1985 journal article

Effect of ascorbate on covalent binding of benzene and phenol metabolites to isolated tissue preparations

Toxicology and Applied Pharmacology, 77(2), 334–343.

By: R. Smart* & V. Zannoni*

MeSH headings : Animals; Ascorbic Acid / physiology; Benzene / metabolism; Binding Sites; Binding, Competitive; Bone Marrow / metabolism; Glutathione / physiology; Guinea Pigs; In Vitro Techniques; Lung / metabolism; Male; Microsomes, Liver / metabolism; NAD(P)H Dehydrogenase (Quinone); Phenols / metabolism; Quinone Reductases / physiology
TL;DR: The results indicate that different metabolites are responsible for a portion of the covalent binding depending upon the substrate employed, and how the dietary intake of ascorbate can result in a differential response to a potentially toxic event in vitro. (via Semantic Scholar)
Sources: Crossref, NC State University Libraries
Added: April 9, 2022

1984 chapter

Ascorbic acid as it relates to the metabolism of drugs and environmental chemicals

In M. Wimick (Ed.), Nutrition in the 20th Century (pp. 21–36). New York: John Wiley and Sons.

By: V. Zannoni, R. Susick & R. Smart

Ed(s): M. Wimick

Sources: NC State University Libraries, ORCID
Added: May 5, 2022

1984 journal article

DT-Diaphorase and peroxidase influence the covalent binding of the metabolites of phenol, the major metabolite of benzene

Molecular Pharmacology, 26(1), 105–111.

By: R. Smart & V. Zannoni

Sources: NC State University Libraries, ORCID
Added: May 5, 2022

Employment

Updated: December 1st, 2021 13:09

1986 - present

North Carolina State University Raleigh, North Carolina, US
Professor; Goodnight Distinguished Chair in Molecular Toxicology Biological Sciences

Education

Updated: December 1st, 2021 13:13

1980 - 1984

University of Michigan Ann Arbor, MI, US
PhD Toxicology

1974 - 1977

University of Massachusetts at Darmouth Darmouth, Massachusetts, US
BS Biology

Funding History

Funding history based on the linked ORCID record. Updated: May 11th, 2022 09:36

grant June 1, 2016 - May 31, 2022
Role of Long Intergenic Noncoding RNA in UVB-induced Apoptosis and Skin Cancer
National Institute of Environmental Health Sciences
grant April 20, 2015 - March 31, 2025
Center for Human Health and the Environment (CHHE)
National Institute of Environmental Health Sciences
grant January 3, 2005 - December 31, 2011
Regulation and Function of C/EBP in UVB Responses
National Institute of Environmental Health Sciences
grant August 1, 1996 - July 31, 2001
MECHANISM OF PESTICIDE MIREX INDUCED TUMOR PROMOTION
National Institute of Environmental Health Sciences
grant May 1, 1990 - May 31, 2015
Role of C/EBP in Cell Survival and Neoplasia
National Cancer Institute
grant May 1, 1990 - April 30, 1996
DIACYLGLYCEROLS AS TUMOR PROMOTERS
National Cancer Institute
grant November 23, 1988 - June 30, 2006
ENVIRONMENTAL HEALTH SCIENCES
National Institute of Environmental Health Sciences
grant April 1, 1979 - September 29, 1992
BIOMEDICAL RESEARCH SUPPORT
National Center for Advancing Translational Sciences
grant July 1, 1977 - June 30, 2026
Molecular Pathways to Pathogenesis in Toxicology
National Institute of Environmental Health Sciences
grant December 1, 1976 - February 28, 1997
MECHANISMS OF PESTICIDE TOXICOLOGY
National Institute of Environmental Health Sciences

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