Robert Drake Mitchell

Works (11)

Updated: July 5th, 2023 15:38

2021 journal article

Characterization of Long Non-Coding RNAs in the Bollworm, Helicoverpa zea, and Their Possible Role in Cry1Ac-Resistance

INSECTS, 13(1).

By: R. Lawrie n, R. Mitchell n, J. Deguenon n, L. Ponnusamy n , D. Reisig* , A. Pozo-Valdivia, R. Kurtz*, R. Roe n

author keywords: long non-coding RNAs; Helicoverpa zea; Bt-resistance; Cry1Ac resistance; RNA-seq; lncRNA; bollworms; gene regulation
TL;DR: Characterization of non-coding genetic mechanisms in Helicoverpa zea will improve the understanding of the genomic evolution of insect resistance, improve the identification of specific regulators of coding genes in general, and is the first step for potentially targeting these regulators for pest control and resistance management. (via Semantic Scholar)
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Sources: Web Of Science, ORCID, NC State University Libraries
Added: December 27, 2021

2021 journal article

Mosquito-Textile Physics: A Mathematical Roadmap to Insecticide-Free, Bite-Proof Clothing for Everyday Life

Insects, 12(7), 636.

By: K. Luan n , A. West*, M. McCord n , E. DenHartog* , Q. Shi*, I. Bettermann *, J. Li *, N. Travanty n ...

author keywords: mosquito; bite-proof garment; model; textile; non-insecticidal; physical barrier
TL;DR: A mathematical model for fabric barriers that resist bites from Aedes aegypti mosquitoes based on textile physical structure and no insecticides is reported, derived from mosquito morphometrics and analysis of mosquito biting behavior. (via Semantic Scholar)
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Sources: Web Of Science, ORCID, NC State University Libraries, Crossref
Added: July 14, 2021

2021 journal article

Tick Ecdysteroid Hormone, Global Microbiota/Rickettsia Signaling in the Ovary versus Carcass during Vitellogenesis in Part-Fed (Virgin) American Dog Ticks, Dermacentor variabilis

MICROORGANISMS, 9(6).

By: L. Ponnusamy n , H. Sutton n, R. Mitchell n, D. Sonenshine*, C. Apperson n & R. Roe n

author keywords: Dermacentor variabilis; ecdysteroid; Rickettsia sp; Francisella sp; qPCR; microbiota
TL;DR: Injections of physiological levels of the tick hormone, 20-hydroxyecdysone (20E), into part-fed (virgin) adult females of the American dog tick, Dermacentor variabilis, attached to the host caused a reduction in density of Rickettsia montanensis in the carcass and an increase in the ovaries compared to buffer-injected controls. (via Semantic Scholar)
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Sources: Web Of Science, ORCID, NC State University Libraries
Added: June 16, 2021

2020 journal article

Ectoparasites of Cattle

VETERINARY CLINICS OF NORTH AMERICA-FOOD ANIMAL PRACTICE, 36(1), 173-+.

By: A. Leon *, R. Mitchell* & D. Watson n

author keywords: Cattle; Ectoparasites; Flies; Myiasis; Lice; Mites; Ticks; Integrated management
MeSH headings : Animals; Cattle; Cattle Diseases / parasitology; Ectoparasitic Infestations / veterinary
TL;DR: Assessing the status of coparasitism with ectoparasites and endopar asites in cattle across agroecosystems is critical in advancing integrated parasite management. (via Semantic Scholar)
Source: Web Of Science
Added: March 23, 2020

2020 journal article

Role of long non-coding RNA in DEET- and fipronil-mediated alteration of transcripts associated with Phase I and Phase II xenobiotic metabolism in human primary hepatocytes

PESTICIDE BIOCHEMISTRY AND PHYSIOLOGY, 167.

By: R. Lawrie n, R. Mitchell n, A. Dhammi n, A. Wallace n, E. Hodgson n & R. Roe n 

author keywords: Long non-coding RNA; DEET; Fipronil; Xenobiotic metabolism; Environmental chemicals; Cytochrome P450
MeSH headings : DEET; Hepatocytes; Humans; Insect Repellents; Pyrazoles; RNA, Long Noncoding
TL;DR: The impact of two environmental chemicals used in and around homes, the insect repellent DEET and the phenylpyrazole insecticide fipronil, and the role of altered lncRNAs associated with xenobiotic induction, human diseases and chemical mixtures is discussed. (via Semantic Scholar)
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Sources: Web Of Science, NC State University Libraries
Added: July 6, 2020

2017 journal article

Differential Expression Profile of lncRNAs from Primary Human Hepatocytes Following DEET and Fipronil Exposure

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, 18(10).

By: R. Mitchell n, A. Wallace n, E. Hodgson n & R. Roe n 

author keywords: DEET; fipronil; long non-coding RNA; lncRNA; primary liver cells; epigenetics; RNA-Seq; transcriptomics; Zika virus; human hepatocytes
MeSH headings : Cells, Cultured; DEET / pharmacology; Epigenomics / methods; Hepatocytes / drug effects; Hepatocytes / metabolism; Humans; Pyrazoles / pharmacology; RNA, Long Noncoding / genetics; Zika Virus / genetics
TL;DR: This initial analysis links several of the dysregulated lncRNAs to processes and pathways critical to proper cellular function, such as the innate and adaptive immune response and the p53 signaling pathway. (via Semantic Scholar)
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Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018

2017 journal article

Infrared light detection by the hailer's organ of adult american dog ticks, Dermacentor variabilis (Ixodida: Ixodidae)

TICKS AND TICK-BORNE DISEASES, 8(5), 764–771.

By: R. Mitchell n, J. Zhu n, A. Carr n, A. Dhammi n, G. Cave n, D. Sonenshine *, R. Roe n 

author keywords: American dog tick; Dermacentor variabilis; Haller's organ; Infrared; TRPA1; Light
MeSH headings : Animals; Dermacentor / physiology; Dermacentor / ultrastructure; Extremities; Infrared Rays; Phototaxis
TL;DR: The ability of ticks to use IR for host finding is consistent with their obligatory hematophagy and has practical applications in tick trapping and the development of new repellents. (via Semantic Scholar)
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14. Life Below Water (OpenAlex)
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018

2017 journal article

Tick Haller's Organ, a New Paradigm for Arthropod Olfaction: How Ticks Differ from Insects

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, 18(7).

By: A. Carr n, R. Mitchell n, A. Dhammi n, B. Bissinger*, D. Sonenshine * & R. Roe n 

author keywords: American dog tick; Dermacentor variabilis; tick; Haller's organ; olfaction; gustation; chemoreception; odorant binding proteins; GPCR; DEET; transcriptome
MeSH headings : Amino Acid Sequence; Animal Structures / anatomy & histology; Animal Structures / physiology; Animals; Behavior, Animal; Insect Proteins / chemistry; Insect Proteins / genetics; Insect Proteins / metabolism; Male; Phylogeny; RNA, Messenger / genetics; RNA, Messenger / metabolism; Sensory Receptor Cells / metabolism; Sequence Analysis, RNA; Smell / genetics; Taste; Ticks / anatomy & histology; Ticks / physiology; Transcriptome / genetics
TL;DR: Data are presented for the first time of the potential hormonal regulation of tick chemosensation; behavioral assays confirmed the role of the Haller’s organ in N,N-diethyl-meta-toluamide (DEET) repellency but showed no role for the Hallers organ in host attachment. (via Semantic Scholar)
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Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018

2016 journal article

Impact of Environmental Chemicals on the Transcriptome of Primary Human Hepatocytes: Potential for Health Effects

Journal of Biochemical and Molecular Toxicology, 30(8), 375–395.

By: R. Mitchell n, A. Dhammi n, A. Wallace n, E. Hodgson n & R. Roe n 

author keywords: DEET; Fipronil; Gene expression; Human hepatocytes; RNA-Seq; Endocrine System; P450
MeSH headings : Chromosome Mapping; DEET / toxicity; Drug Combinations; Genome, Human; Hepatocytes / cytology; Hepatocytes / drug effects; Hepatocytes / metabolism; Humans; Insect Repellents / toxicity; Insecticides / toxicity; Molecular Sequence Annotation; Primary Cell Culture; Pyrazoles / toxicity; Sequence Analysis, RNA; Transcriptome / drug effects
TL;DR: The overall treatment responses, specific pathways, and individual transcripts affected were discussed at different levels of fold‐change and changes found in transcript levels in response to treatments will require further research to understand their importance in overall cellular, organ, and organismic function. (via Semantic Scholar)
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Sources: Web Of Science, Crossref, NC State University Libraries
Added: August 6, 2018

2016 journal article

Mevalonate-Farnesal Biosynthesis in Ticks: Comparative Synganglion Transcriptomics and a New Perspective

PLOS ONE, 11(3).

By: J. Zhu n, S. Khalil  n, R. Mitchell n, B. Bissinger n, N. Egekwu*, D. Sonenshine *, R. Roe n 

MeSH headings : Aedes / enzymology; Amino Acid Sequence; Animals; Biosynthetic Pathways; Cholesterol / biosynthesis; Corpora Allata / metabolism; Farnesol / analogs & derivatives; Farnesol / metabolism; Female; Geranyltranstransferase / chemistry; Geranyltranstransferase / metabolism; Juvenile Hormones / metabolism; Male; Methyltransferases / chemistry; Methyltransferases / metabolism; Mevalonic Acid / metabolism; Mice; Models, Biological; Molecular Sequence Data; NAD (+) and NADP (+) Dependent Alcohol Oxidoreductases / chemistry; NAD (+) and NADP (+) Dependent Alcohol Oxidoreductases / metabolism; Phylogeny; Sequence Alignment; Ticks / genetics; Ticks / metabolism; Transcriptome / genetics
TL;DR: T ticks do not synthesize JH III but have the mevalonate pathway and may produce a JHIII precursor, according to next-gen sequencing of the tick synganglion transcriptome. (via Semantic Scholar)
UN Sustainable Development Goals Color Wheel
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2. Zero Hunger (Web of Science)
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018

2014 journal article

Molecular traces of alternative social organization in a termite genome

Nature Communications, 5.

By: N. Terrapon, C. Li, H. Robertson, L. Ji, X. Meng, W. Booth, Z. Chen, C. Childers ...

Source: NC State University Libraries
Added: August 6, 2018

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