Ryan Weeks

Works (5)

Updated: September 6th, 2023 05:01

2023 journal article

Developmental cadmium exposure disrupts zebrafish vestibular calcium channels interfering with otolith formation and inner ear function

NEUROTOXICOLOGY, 96, 129–139.

By: A. Green n, A. Wall n, R. Weeks n, C. Mattingly n , K. Marsden n  & A. Planchart n 

author keywords: Cadmium; Developmental toxicology; Behavior; Vestibular system; P2X receptor; Zebrafish
MeSH headings : Animals; Zebrafish; Cadmium / toxicity; Otolithic Membrane; Vestibule, Labyrinth; Vestibular Diseases
TL;DR: Cadmium-induced ototoxicity is linked to vestibular-based behavioral abnormalities and auditory sensitivity following developmental exposure, and calcium ion channel function is associated with these defects. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Sources: Web Of Science, NC State University Libraries
Added: June 12, 2023

2023 article

The Effects of Long-term, Low-dose & beta;-N-methylamino-l-alanine (BMAA) Exposures in Adult SODG93R Transgenic Zebrafish

Weeks, R. D., Banack, S. A., Howell, S., Thunga, P., Green, A. J., Cox, P. A., … Metcalf, J. S. (2023, August 8). The Effects of Long-term, Low-dose & beta;-N-methylamino-l-alanine (BMAA) Exposures in Adult SODG93R Transgenic Zebrafish. NEUROTOXICITY RESEARCH, Vol. 8.

By: R. Weeks n, S. Banack *, S. Howell n, P. Thunga n , A. Green n, P. Cox *, A. Planchart n , J. Metcalf *

author keywords: L-BMAA; D-BMAA; AEG; DAB; ALS; Zebrafish; Neurotoxicity; Neurodegeneration; SOD1
TL;DR: While the results revealed low concentrations of BMAA in the brains of exposed fish, there was no evidence of decreased swim performance or behavioral differences that might be reflective of neurodegenerative disease. (via Semantic Scholar)
UN Sustainable Development Goal Categories
14. Life Below Water (OpenAlex)
Sources: Web Of Science, NC State University Libraries
Added: August 21, 2023

2023 article

The Effects of Long-term, Low-dose beta-N-methylamino-L-alanine (BMAA) Exposures in Adult SODG93R (Aug, 10.1007/s12640-023-00658-z, 2023)

Weeks, R. D., Banack, S. A., Howell, S., Thunga, P., Metcalf, J. S., Green, A. J., … Planchart, A. (2023, August 24). NEUROTOXICITY RESEARCH, Vol. 8.

By: R. Weeks n, S. Banack *, S. Howell n, P. Thunga n , J. Metcalf *, A. Green n, P. Cox *, A. Planchart n 

UN Sustainable Development Goal Categories
Sources: Web Of Science, NC State University Libraries
Added: September 5, 2023

2021 journal article

Canine Papillomavirus 2 E6 Does Not Interfere With UVB-Induced Upregulation of p53 and p53-Regulated Genes

FRONTIERS IN VETERINARY SCIENCE, 8.

By: S. Quinlan n, S. May n, R. Weeks n, H. Yuan * & J. Luff n

author keywords: canine papillomavirus type 2; E6; p53; LncRNA-p21; bak; bax
TL;DR: It is determined that cutaneousCPV2 E6 does not degrade p53, or interfere with the upregulation of p53-regulated genes p21, Bax, Bak, or lncRNA-p21, suggesting that CPV2 may use a p53 -independent mechanism to contribute to oncogenesis. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (Web of Science; OpenAlex)
5. Gender Equality (Web of Science)
Source: Web Of Science
Added: March 22, 2021

2020 journal article

Abrogation of Constitutive and Induced Type I and Type III Interferons and Interferon-Stimulated Genes in Keratinocytes by Canine Papillomavirus 2 E6 and E7

VIRUSES-BASEL, 12(6).

By: S. Quinlan n, S. May n, R. Weeks n, H. Yuan * & J. Luff n

author keywords: canine; papillomavirus; interferon; interferon-stimulated gene; E6; E7
MeSH headings : Animals; Cell Line; Dogs; Humans; Interferon-beta / metabolism; Keratinocytes / immunology; Keratinocytes / virology; Papillomaviridae / immunology; Papillomavirus E7 Proteins / genetics; Papillomavirus Infections / immunology; Papillomavirus Infections / pathology; Papillomavirus Infections / veterinary; Skin Neoplasms / virology
TL;DR: It is determined that CPV2 E6 and E7 both impact expression of antiviral cytokines in canine keratinocytes, albeit likely through different mechanisms, and that E7 but not E6 abrogates signaling through the type I IFN receptor. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (Web of Science; OpenAlex)
5. Gender Equality (Web of Science)
Source: Web Of Science
Added: August 17, 2020

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