Ryan Weeks

Works (5)

Updated: April 23rd, 2025 19:30

2023 article

Correction to: The Effects of Long-term, Low-dose β-N-methylamino-L-alanine (BMAA) Exposures in Adult SODG93R Transgenic Zebrafish

Weeks, R. D., Banack, S. A., Howell, S., Thunga, P., Metcalf, J. S., Green, A. J., … Planchart, A. (2023, August 24). Neurotoxicity Research, Vol. 8.

By: R. Weeks n, S. Banack *, S. Howell n, P. Thunga n , J. Metcalf *, A. Green n, P. Cox *, A. Planchart n 

topics (OpenAlex): Animal testing and alternatives; Animal Genetics and Reproduction; Cancer, Hypoxia, and Metabolism
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Sources: Web Of Science, NC State University Libraries
Added: September 5, 2023

2023 article

Developmental cadmium exposure disrupts zebrafish vestibular calcium channels interfering with otolith formation and inner ear function

Green, A. J., Wall, A. R., Weeks, R. D., Mattingly, C. J., Marsden, K. C., & Planchart, A. (2023, April 14). NeuroToxicology, Vol. 96, pp. 129–139.

By: A. Green n, A. Wall n, R. Weeks n, C. Mattingly n , K. Marsden n  & A. Planchart n 

author keywords: Cadmium; Developmental toxicology; Behavior; Vestibular system; P2X receptor; Zebrafish
MeSH headings : Animals; Zebrafish; Cadmium / toxicity; Otolithic Membrane; Vestibule, Labyrinth; Vestibular Diseases
topics (OpenAlex): Hearing, Cochlea, Tinnitus, Genetics; Marine animal studies overview; Zebrafish Biomedical Research Applications
TL;DR: Cadmium-induced ototoxicity is linked to vestibular-based behavioral abnormalities and auditory sensitivity following developmental exposure, and calcium ion channel function is associated with these defects. (via Semantic Scholar)
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Sources: Web Of Science, NC State University Libraries
Added: June 12, 2023

2023 article

The Effects of Long-term, Low-dose β-N-methylamino-l-alanine (BMAA) Exposures in Adult SODG93R Transgenic Zebrafish

Weeks, R. D., Banack, S. A., Howell, S., Thunga, P., Metcalf, J. S., Green, A. J., … Planchart, A. (2023, August 8). Neurotoxicity Research, Vol. 8.

By: R. Weeks n, S. Banack *, S. Howell n, P. Thunga n , J. Metcalf *, A. Green n, P. Cox *, A. Planchart n 

author keywords: L-BMAA; D-BMAA; AEG; DAB; ALS; Zebrafish; Neurotoxicity; Neurodegeneration; SOD1
MeSH headings : Animals; Zebrafish; Neurodegenerative Diseases / etiology; Amyotrophic Lateral Sclerosis / chemically induced; Amyotrophic Lateral Sclerosis / genetics; Amyotrophic Lateral Sclerosis / complications; Amino Acids, Diamino / toxicity; Animals, Genetically Modified; Neurotoxins / toxicity; Superoxide Dismutase
topics (OpenAlex): Amyotrophic Lateral Sclerosis Research; Neurogenetic and Muscular Disorders Research; Prion Diseases and Protein Misfolding
TL;DR: While the results revealed low concentrations of BMAA in the brains of exposed fish, there was no evidence of decreased swim performance or behavioral differences that might be reflective of neurodegenerative disease. (via Semantic Scholar)
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Sources: Web Of Science, NC State University Libraries
Added: August 21, 2023

2021 article

Canine Papillomavirus 2 E6 Does Not Interfere With UVB-Induced Upregulation of p53 and p53-Regulated Genes

Quinlan, S., May, S., Weeks, R., Yuan, H., & Luff, J. (2021, March 3). Frontiers in Veterinary Science.

By: S. Quinlan n, S. May n, R. Weeks n, H. Yuan * & J. Luff n

author keywords: canine papillomavirus type 2; E6; p53; LncRNA-p21; bak; bax
topics (OpenAlex): Veterinary Oncology Research; Virus-based gene therapy research; Cervical Cancer and HPV Research
TL;DR: It is determined that cutaneousCPV2 E6 does not degrade p53, or interfere with the upregulation of p53-regulated genes p21, Bax, Bak, or lncRNA-p21, suggesting that CPV2 may use a p53 -independent mechanism to contribute to oncogenesis. (via Semantic Scholar)
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3. Good Health and Well-being (Web of Science; OpenAlex)
5. Gender Equality (Web of Science)
Source: Web Of Science
Added: March 22, 2021

2020 article

Abrogation of Constitutive and Induced Type I and Type III Interferons and Interferon-Stimulated Genes in Keratinocytes by Canine Papillomavirus 2 E6 and E7

Quinlan, S., May, S., Weeks, R., Yuan, H., & Luff, J. A. (2020, June 23). Viruses.

By: S. Quinlan n, S. May n, R. Weeks n, H. Yuan * & J. Luff n

author keywords: canine; papillomavirus; interferon; interferon-stimulated gene; E6; E7
MeSH headings : Animals; Cell Line; Dogs; Humans; Interferon-beta / metabolism; Keratinocytes / immunology; Keratinocytes / virology; Papillomaviridae / immunology; Papillomavirus E7 Proteins / genetics; Papillomavirus Infections / immunology; Papillomavirus Infections / pathology; Papillomavirus Infections / veterinary; Skin Neoplasms / virology
topics (OpenAlex): Cervical Cancer and HPV Research; Veterinary Oncology Research; Herpesvirus Infections and Treatments
TL;DR: It is determined that CPV2 E6 and E7 both impact expression of antiviral cytokines in canine keratinocytes, albeit likely through different mechanisms, and that E7 but not E6 abrogates signaling through the type I IFN receptor. (via Semantic Scholar)
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3. Good Health and Well-being (Web of Science; OpenAlex)
5. Gender Equality (Web of Science)
Source: Web Of Science
Added: August 17, 2020

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