@article{lindaberry_vaden_aicher_seiler_robertson_cianciolo_yang_gookin_2021, title={Proteinuria in dogs with gallbladder mucocele formation: A retrospective case control study}, volume={35}, ISSN={["1939-1676"]}, DOI={10.1111/jvim.16051}, abstractNote={AbstractBackgroundProteinuria is an independent risk factor for morbidity and mortality in dogs. An association between proteinuria and gallbladder mucocele formation in dogs is unknown.ObjectiveDetermine if gallbladder mucocele formation or clinicopathologic comorbidities are associated with proteinuria.AnimalsTwenty‐five dogs with mucocele formation and 25 breed and age‐matched control dogs from a prior study.MethodsRetrospective case control study. Proteinuria defined by calculated urine dipstick protein concentration (mg/mL) to urine specific gravity (USG) ratio. Clinicopathologic findings, postcosyntropin cortisol concentration, thyroid function profile, and illness severity score were recorded.ResultsMedian urine dipstick protein concentration to USG ratio and number of dogs having a ratio ≥1.5 were significantly higher for dogs with mucocele formation compared to control dogs. Proteinuria was not significantly associated with CBC or serum biochemistry profile abnormalities but increased in relation to severity of illness.Conclusions and Clinical ImportanceGallbladder mucocele formation is significantly associated with proteinuria in dogs. Diagnosis and treatment of proteinuria in dogs with mucocele formation might minimize long term kidney morbidity in these patients.}, number={2}, journal={JOURNAL OF VETERINARY INTERNAL MEDICINE}, author={Lindaberry, Crystal and Vaden, Shelly and Aicher, Kathleen M. and Seiler, Gabriela and Robertson, James and Cianciolo, Rachel and Yang, Ching and Gookin, Jody L.}, year={2021}, month={Mar}, pages={878–886} }
 @article{nyankima_kasoji_cianciolo_dayton_chang_2019, title={The biological response of rodent kidneys to low frequency, full volume diagnostic contrast-enhanced ultrasound imaging: Pilot data}, volume={25}, ISSN={["2352-3409"]}, DOI={10.1016/j.dib.2019.104170}, abstractNote={With the growth of contrast-enhanced ultrasound (CEUS) clinically, there are concerns about histologic bioeffects in regards to the implementation of high mechanical index (MI) imaging, such as the imaging sequence used for a specific CEUS technique known as flash-replenishment. The data presented are results from a pilot study, which explored flash-replenishment with high and moderate MI imaging sequences at time points of 24 hours and 2 weeks post imaging. This pilot study was followed by a larger study, which can be found in a journal article entitled "Histological and Blood Chemistry Examination of the Rodent Kidney After Exposure to Flash-Replenishment Ultrasound Contrast Imaging" Nyankima et al., 2019.}, journal={DATA IN BRIEF}, author={Nyankima, A. Gloria and Kasoji, Sandeep and Cianciolo, Rachel and Dayton, Paul A. and Chang, Emily H.}, year={2019}, month={Aug} }
 @article{levine_cianciolo_linder_bizikova_birkenheuer_brooks_salous_nordone_bellinger_marr_et al._2017, title={Endothelial alterations in a canine model of immune thrombocytopenia}, volume={30}, ISSN={0953-7104 1369-1635}, url={http://dx.doi.org/10.1080/09537104.2017.1378807}, DOI={10.1080/09537104.2017.1378807}, abstractNote={Abstract Bleeding heterogeneity amongst patients with immune thrombocytopenia (ITP) is poorly understood. Platelets play a role in maintaining endothelial integrity, and variable thrombocytopenia-induced endothelial changes may influence bleeding severity. Platelet-derived endothelial stabilizers and markers of endothelial integrity in ITP are largely underexplored. We hypothesized that, in a canine ITP model, thrombocytopenia would lead to alterations in the endothelial ultrastructure and that the Von Willebrand factor (vWF) would serve as a marker of endothelial injury associated with thrombocytopenia. Thrombocytopenia was induced in healthy dogs with an antiplatelet antibody infusion; control dogs received an isotype control antibody. Cutaneous biopsies were obtained prior to thrombocytopenia induction, at platelet nadir, 24 hours after nadir, and on platelet recovery. Cutaneous capillaries were assessed by electron microscopy for vessel thickness, the number of pinocytotic vesicles, the number of large vacuoles, and the number of gaps between cells. Pinocytotic vesicles are thought to represent an endothelial membrane reserve that can be used for repair of damaged endothelial cells. Plasma samples were assessed for vWF. ITP dogs had significantly decreased pinocytotic vesicle numbers compared to control dogs (P = 0.0357) and the increase in plasma vWF from baseline to 24 hours correlated directly with the endothelial large vacuole score (R = 0.99103; P < 0.0001). This direct correlation between plasma vWF and the number of large vacuoles, representing the vesiculo-vacuolar organelle (VVO), a permeability structure, suggests that circulating vWF could serve as a biomarker for endothelial alterations and potentially a predictor of thrombocytopenic bleeding. Overall, our results indicate that endothelial damage occurs in the canine ITP model and variability in the degree of endothelial damage may account for differences in the bleeding phenotype among patients with ITP.}, number={1}, journal={Platelets}, publisher={Informa UK Limited}, author={LeVine, Dana N. and Cianciolo, Rachel E. and Linder, Keith E. and Bizikova, Petra and Birkenheuer, Adam J. and Brooks, Marjory B. and Salous, Abdelghaffar K. and Nordone, Shila K. and Bellinger, Dwight A. and Marr, Henry and et al.}, year={2017}, month={Nov}, pages={88–97} }
 @misc{vaden_littman_cianciolo_2013, title={Familial renal disease in soft-coated wheaten terriers}, volume={23}, ISSN={["1479-3261"]}, DOI={10.1111/vec.12027}, abstractNote={AbstractObjectiveTo review what is known about the familial renal diseases in soft‐coated wheaten terriers (SCWT), provide an update in developments in this field including the relationship with protein‐losing nephropathy (PLN) and the potential association with protein‐losing enteropathy (PLE).Data SourcesInformation was derived from studies of dogs maintained in the North Carolina State University colony, information contained within an open registry of affected dogs, and data gathered from the general population of wheaten terriers at risk as well as studies performed on banked DNA samples from affected SCWT in the general population and normal geriatric dogs seen at the University of Pennsylvania (PennVet).Human Data SynthesisA two‐hit pathogenesis has been proposed in some types of human focal segmental glomerulosclerosis, specifically the subset of cases that are associated with a podocytopathy. At risk podocytes may be predisposed to injury by disease processes that would be reversible in other patients.Veterinary Data SynthesisMutations were found in association with PLN in SCWT, indicating a podocytopathy that causes a change in glomerular permselectivity. This podocytopathy leads to the development of lesions resembling focal segmental glomerulosclerosis. There is also strong evidence supporting a high prevalence of food hypersensitivity reactions in SCWT, although it is unclear if these reactions have a primary or secondary role in the development of PLE. There are also suggestions of immunodysregulation in affected SCWT.ConclusionsPLN in SCWT is due to a podocytopathy. The cause of PLE has not been identified; however, it is possible that PLE develops from a functional‐structural abnormality in the intestines and food allergies develop as secondary phenomena. It is also possible that inflammatory events that are the result of either immunodysregulation or food allergies might lead to the development of PLE. In either case, PLE most likely exacerbates PLN in affected SCWT.}, number={2}, journal={JOURNAL OF VETERINARY EMERGENCY AND CRITICAL CARE}, author={Vaden, Shelly L. and Littman, Meryl P. and Cianciolo, Rachel E.}, year={2013}, pages={174–183} }
 @article{johnson_cianciolo_gessner_dayton_2012, title={A pilot study to assess markers of renal damage in the rodent kidney after exposure to 7 MHz ultrasound pulse sequences designed to cause microbubble translation and disruption}, volume={38}, number={1}, journal={Ultrasound in Medicine and Biology}, author={Johnson, K. and Cianciolo, R. and Gessner, R. C. and Dayton, P. A.}, year={2012}, pages={168–172} }
 @article{xie_cianciolo_hulette_lee_qi_cofer_johnson_2012, title={Magnetic resonance histology of age-related nephropathy in the Sprague Dawley rat}, volume={40}, number={5}, journal={Toxicologic Pathology}, author={Xie, L. K. and Cianciolo, R. E. and Hulette, B. and Lee, H. W. and Qi, Y. and Cofer, G. and Johnson, G. A.}, year={2012}, pages={764–778} }
 @article{nabity_lees_cianciolo_boggess_steiner_suchodolski_2012, title={Urinary biomarkers of renal disease in dogs with x-linked hereditary nephropathy}, volume={26}, number={2}, journal={Journal of Veterinary Internal Medicine}, author={Nabity, M. B. and Lees, G. E. and Cianciolo, R. and Boggess, M. M. and Steiner, J. M. and Suchodolski, J. S.}, year={2012}, pages={282–293} }
 @article{backlund_cianciolo_cook_clubb_lees_2011, title={Minimal change glomerulopathy in a cat}, volume={13}, number={4}, journal={Journal of Feline Medicine and Surgery}, author={Backlund, B. and Cianciolo, R. E. and Cook, A. K. and Clubb, F. J. and Lees, G. E.}, year={2011}, pages={291–295} }
 @article{nabity_lees_dangott_cianciolo_suchodolski_steiner_2011, title={Proteomic analysis of urine from male dogs during early stages of tubulointerstitial injury in a canine model of progressive glomerular disease}, volume={40}, number={2}, journal={Veterinary Clinical Pathology}, author={Nabity, M. B. and Lees, G. E. and Dangott, L. J. and Cianciolo, R. and Suchodolski, J. S. and Steiner, J. M.}, year={2011}, pages={222–236} }
 @misc{lees_cianciolo_clubb_2011, title={Renal biopsy and pathologic evaluation of glomerular disease}, volume={26}, number={3}, journal={Topics in Companion Animal Medicine}, author={Lees, G. E. and Cianciolo, R. E. and Clubb, F. J.}, year={2011}, pages={143–153} }
 @article{cianciolo_rhodes_haskins_clubb_lees_2011, title={Renal failure associated with mucopolysaccharidosis type I in a cat from a MPS I research colony}, volume={61}, number={5}, journal={Comparative Medicine}, author={Cianciolo, R. E. and Rhodes, J. L. and Haskins, M. E. and Clubb, F. J. and Lees, G. E.}, year={2011}, pages={441–444} }