@article{geist_dubois_nichols_caughey_merricks_raymer_gallippi_2016, title={experimental validation of ARFI surveillance of subcutaneous hemorrhage (ASSH) using calibrated infusions in a tissue-mimicking model and dogs}, volume={38}, number={5}, journal={Ultrasonic Imaging}, author={Geist, R. E. and DuBois, C. H. and Nichols, T. C. and Caughey, M. C. and Merricks, E. P. and Raymer, R. and Gallippi, C. M.}, year={2016}, pages={346–358} }
 @article{geist_gallippi_nichols_merricks_caughey_2014, title={In Vivo ARFI Surveillance of Subcutaneous Hemorrhage (ASSH) for Monitoring rcFVIII Dose Response in Hemophilia A Dogs}, ISSN={["1948-5719"]}, DOI={10.1109/ultsym.2014.0572}, abstractNote={Acoustic Radiation Force Impulse (ARFI) ultrasound is used in ARFI Surveillance of Subcutaneous Hemorrhage (ASSH), a new in vivo hemostasis assay, to assess bleeding response in hemophilia A dogs. ASSH bleeding parameters were calculated from a small dose response study with 7 hemostatically normal dogs and 7 dogs exhibiting severe hemophilia A. Hemophilia A dogs were imaged in the naive state and/or when prophylactically treated with different levels of recombinant canine FVIII before bleeding was induced. A standardized injury of a 1-2mm vein by needle puncture induced subcutaneous bleeding in soft tissue. Bleeding was monitored by ASSH for 60 minutes. There was a significant difference (p<;0.05, Wilcoxon ranksum) in ASSH bleeding rate (BR) and a 34.8% reduction in occurrence of abnormal ASSH time to hemostasis (TTH) between naive hemophilia A and hemophilia A treated to 100% rcFVIII cohorts. These data indicate that ASSH could be relevant in differentiating bleeding responses to different levels of rcFVIII treatment.}, journal={2014 IEEE INTERNATIONAL ULTRASONICS SYMPOSIUM (IUS)}, author={Geist, Rebecca E. and Gallippi, Catcrina M. and Nichols, Timothy C. and Merricks, Elizabeth P. and Caughey, Melissa C.}, year={2014}, pages={2296–2299} }