Works (34)
Updated: August 16th, 2024 13:38
2021 journal article
Functional Diversification, Redundancy, and Epistasis among Paralogs of the Drosophila melanogaster Obp50a-d Gene Cluster
MOLECULAR BIOLOGY AND EVOLUTION, 38(5), 2030–2044.
author keywords: multigene families; functional diversification; transcriptional niche; RNAseq; odorant-binding proteins; evolutionary genetics
MeSH headings : Animals; Drosophila melanogaster / genetics; Drosophila melanogaster / metabolism; Epistasis, Genetic; Evolution, Molecular; Fat Body / metabolism; Female; Genitalia, Male / metabolism; Male; Multigene Family; Phenotype; Pupa / metabolism; Receptors, Odorant / genetics; Receptors, Odorant / metabolism
TL;DR:
There is functional diversification within the Obp50 cluster with Ob p50a contributing to development and Obp 50d to stress resistance, and the deletion–reinsertion approach applied provides a general paradigm for the genetic dissection of paralogs of multigene families.
(via Semantic Scholar)
open access via academic.oup.com (publisher PDF)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Source: Web Of Science
Added: June 10, 2021
2020 journal article
Gene expression networks in the Drosophila Genetic Reference Panel
GENOME RESEARCH, 30(3), 485–496.
MeSH headings : Animals; DNA Transposable Elements; Drosophila melanogaster / genetics; Drosophila melanogaster / metabolism; Drosophila melanogaster / microbiology; Female; Gene Expression Regulation; Gene Regulatory Networks; Genetic Variation; High-Throughput Nucleotide Sequencing; Male; Microbiota / genetics; Quantitative Trait Loci; Sequence Analysis, RNA
TL;DR:
This study performed deep RNA sequencing of 200 Drosophila Genetic Reference Panel inbred lines with complete genome sequences and mapped expression quantitative trait loci for annotated genes, novel transcribed regions, transposable elements and microbial species, providing new insights regarding the role of natural genetic variation in regulating gene expression.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Source: Web Of Science
Added: April 14, 2020
2020 journal article
Genotype by environment interaction for gene expression in Drosophila melanogaster
NATURE COMMUNICATIONS, 11(1).
MeSH headings : Animals; Drosophila melanogaster / genetics; Female; Gene Expression; Gene Expression Regulation; Gene Regulatory Networks; Gene-Environment Interaction; Genes, Insect; Genetic Variation; Genotype; Male; Quantitative Trait Loci; RNA-Seq; Temperature; Transcriptome
TL;DR:
It is shown that developing under different temperatures changes the genetic architecture of regulatory variation in Drosophila melanogaster gene expression yet the co- expression network remains robust, and data suggest that stabilizing selection on gene expression may promote co-expression network robustness.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
13. Climate Action
(Web of Science)
15. Life on Land
(OpenAlex)
Source: Web Of Science
Added: November 30, 2020
2014 journal article
Natural variation in genome architecture among 205 Drosophila melanogaster Genetic Reference Panel lines
Genome Research, 24(7), 1193–1208.
Source: NC State University Libraries
Added: August 6, 2018
2009 journal article
Co-regulated transcriptional networks contribute to natural genetic variation in Drosophila sleep
NATURE GENETICS, 41(3), 371–375.
MeSH headings : Animals; Animals, Genetically Modified; Animals, Inbred Strains; Drosophila / genetics; Drosophila Proteins / genetics; Female; Gene Expression Regulation / physiology; Gene Regulatory Networks / physiology; Genes, Insect; Genetic Variation / physiology; Genome, Insect; Genome-Wide Association Study / veterinary; Male; Models, Biological; Molecular Sequence Data; Polymorphism, Genetic; Sleep / genetics
TL;DR:
It is independently confirmed that molecular polymorphisms in Catsup (Catecholamines up) are associated with variation in sleep and that P-element mutations in four candidate genes affect sleep and gene expression and co-regulated gene expression using P- element mutants are confirmed.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
Source: Web Of Science
Added: August 6, 2018
2009 journal article
Systems genetics of complex traits in Drosophila melanogaster
NATURE GENETICS, 41(3), 299–307.
MeSH headings : Amino Acid Sequence; Animals; Animals, Inbred Strains; Base Sequence; Chromosome Mapping; Drosophila melanogaster / genetics; Female; Gene Regulatory Networks / physiology; Genetic Variation / physiology; Genetics, Population / methods; Male; Molecular Sequence Data; Phenotype; Quantitative Trait, Heritable; RNA, Messenger / analysis; RNA, Messenger / genetics; RNA, Messenger / metabolism; Sequence Homology, Amino Acid; Tissue Distribution
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
15. Life on Land
(OpenAlex)
Source: Web Of Science
Added: August 6, 2018
2007 journal article
Association of polymorphisms in odorant-binding protein genes with variation in olfactory response to benzaldehyde in Drosophila
GENETICS, 177(3), 1655–1665.
MeSH headings : Animals; Benzaldehydes; Drosophila Proteins / genetics; Drosophila melanogaster / genetics; Drosophila melanogaster / physiology; Female; Genes, Insect; Genetics, Population; Male; Models, Molecular; Molecular Sequence Data; Multigene Family; Nucleic Acid Conformation; Odorants; Phenotype; Polymorphism, Genetic; Polymorphism, Single Nucleotide; RNA Precursors / chemistry; RNA Precursors / genetics; Receptors, Odorant / genetics
TL;DR:
Model predictions of alternative pre-mRNA secondary structures associated with polymorphic sites suggest that alterations in Obp mRNA structure could contribute to phenotypic variation in olfactory behavior.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Source: Web Of Science
Added: August 6, 2018
2006 journal article
Candidate genes affecting Drosophila life span identified by integrating microarray gene expression analysis and QTL mapping
MECHANISMS OF AGEING AND DEVELOPMENT, 128(3), 237–249.
author keywords: life span; microarray gene expression; QTL; Drosophila aging
MeSH headings : Aging / genetics; Aging / physiology; Animals; Biomarkers; Chromosome Mapping; Cytochrome P-450 Enzyme System / genetics; Drosophila / genetics; Drosophila / physiology; Energy Metabolism / genetics; Gene Expression Regulation / physiology; Intercellular Signaling Peptides and Proteins / genetics; Longevity / genetics; Oligonucleotide Array Sequence Analysis; Oxidoreductases / genetics; Quantitative Trait Loci / genetics; Signal Transduction / genetics; Signal Transduction / physiology; Transcription, Genetic; Ubiquitin / genetics
TL;DR:
This study investigated gene expression changes between two strains of Drosophila for which quantitative trait loci affecting life span were identified previously, and identified 49 candidate genes and four pathways that could potentially be responsible for regulating life span and involved in the process of aging in Drosophile and humans.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Source: Web Of Science
Added: August 6, 2018
2006 journal article
Phenotypic variation and natural selection at Catsup, a pleiotropic quantitative trait gene in Drosphila
CURRENT BIOLOGY, 16(9), 912–919.
MeSH headings : Animals; Catecholamines / metabolism; Drosophila / anatomy & histology; Drosophila / genetics; Drosophila Proteins / chemistry; Drosophila Proteins / genetics; Drosophila melanogaster / anatomy & histology; Drosophila melanogaster / genetics; Female; Genetic Variation; Genotype; Longevity / genetics; Male; Molecular Sequence Data; Motor Activity / genetics; Phenotype; Quantitative Trait Loci; Quantitative Trait, Heritable; Selection, Genetic
TL;DR:
Molecular population genetic analyses of Catsup sequences are consistent with balancing selection maintaining multiple functional polymorphisms and identify potentially functional variants in protein coding regions that have large effects and are not common.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Source: Web Of Science
Added: August 6, 2018
2006 journal article
Relationships between the phagocytic ability of milk macrophages and polymorphonuclear cells and somatic cell counts in uninfected cows
Canadian Journal of Veterinary Research, 70(1), 68–74.
Source: NC State University Libraries
Added: August 6, 2018
2005 journal article
Drosophila bristles and the nature of quantitative genetic variation
Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences, 360(1459), 1513–1527.
Source: NC State University Libraries
Added: August 6, 2018
2005 article
Genetics and genomics of Drosophila mating behavior
Mackay, T. F. C., Heinsohn, S. L., Lyman, R. F., Moehring, A. J., Morgan, T. J., & Rollmann, S. M. (2005, May 3). PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, Vol. 102, pp. 6622–6629.
MeSH headings : Animals; Chromosomes; Copulation / physiology; Drosophila melanogaster / genetics; Drosophila melanogaster / physiology; Female; Genes, Insect / genetics; Genomics; Male; Phenotype; Sexual Behavior, Animal / physiology; Transcription, Genetic / genetics
TL;DR:
Drosophila melanogaster was subjected to 29 generations of replicated divergent artificial selection for mating speed, and the phenotypic response to selection was highly asymmetrical in the direction of reduced mating speed.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
15. Life on Land
(Web of Science)
Source: Web Of Science
Added: August 6, 2018
2005 journal article
Polygenic mutation in Drosophila melanogaster: Mapping spontaneous mutations affecting sensory bristle number
GENETICS, 170(4), 1723–1735.
MeSH headings : Animals; Chromosome Mapping; Drosophila melanogaster / genetics; Genes, Insect; Genetic Complementation Test; Genetic Variation; Genome, Insect; Mutation; Quantitative Trait Loci; Quantitative Trait, Heritable; Selection, Genetic; X Chromosome
TL;DR:
Estimates of the numbers of mutations and mutational effects were consistent with diploid per-character mutation rates for bristle traits and imply that >2% of the genome could affect just one bristle trait and that there must be extensive pleiotropy for quantitative phenotypes.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
13. Climate Action
(Web of Science)
15. Life on Land
(Web of Science)
Source: Web Of Science
Added: August 6, 2018
2003 journal article
Dopa decarboxylase (Ddc) affects variation in Drosophila longevity
NATURE GENETICS, 34(4), 429–433.
MeSH headings : Animals; Base Sequence; Chromosome Mapping; DNA / genetics; Dopa Decarboxylase / genetics; Drosophila melanogaster / enzymology; Drosophila melanogaster / genetics; Female; Genes, Insect; Genetic Complementation Test; Genetic Variation; Longevity / genetics; Male; Molecular Sequence Data; Mutation; Polymorphism, Genetic; Quantitative Trait Loci; Sequence Homology, Nucleic Acid; Species Specificity
TL;DR:
Variation in the synthesis of bioamines as a factor contributing to natural variation in individual life span is implicate by mapping quantitative trait loci affecting variation in longevity between two Drosophila melanogaster strains.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Source: Web Of Science
Added: August 6, 2018
2003 journal article
Quantitative analysis of bristle number in Drosophila mutants identifies genes involved in neural development
CURRENT BIOLOGY, 13(16), 1388–1397.
MeSH headings : Animals; Drosophila / anatomy & histology; Drosophila / genetics; Drosophila / growth & development; Gene Expression Regulation, Developmental; Genes, Insect; Mutation; Peripheral Nerves / growth & development
TL;DR:
The findings establish the use of quantitative trait analysis for functional genome annotation through forward genetics, and similar analyses of quantitative effects of P element insertions will facilitate the understanding of the genes affecting many other complex traits in Drosophila.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Source: Web Of Science
Added: August 6, 2018
2003 journal article
Transcription profiling in Drosophila eyes that overexpress the human glaucoma-associated trabecular meshwork-inducible glucocorticoid response protein/myocilin (TIGR/MYOC)
Genetics, 163(2), 637–645.
Source: NC State University Libraries
Added: August 6, 2018
2002 journal article
Impaired olfactory behavior in mice deficient in the a subunit of G(0)
BRAIN RESEARCH, 941(1-2), 62–71.
author keywords: G protein; knock-out mouse; olfaction; chemoreception; behavioral genetics; olfactory bulb
MeSH headings : Analysis of Variance; Animals; Behavior, Animal; Female; GTP-Binding Protein alpha Subunits; Heterotrimeric GTP-Binding Proteins / deficiency; Heterotrimeric GTP-Binding Proteins / genetics; Immunohistochemistry; Male; Mice; Mice, Knockout; Odorants; Olfactory Bulb / cytology; Olfactory Receptor Neurons; Phenotype; Smell / genetics
TL;DR:
Gαo is necessary for the expression of olfactory behavior under normal conditions and dependent on genetic background, but is not essential for the formation and maintenance of glomeruli.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Source: Web Of Science
Added: August 6, 2018
2002 journal article
The hairy: A quantitative trait locus for Drosophila sensory bristle number
Genetics, 162(1), 155–164.
Source: NC State University Libraries
Added: August 6, 2018
2002 journal article
Variation in Drosophila sensory bristle number at 'Evolution Canyon'
GENETICS RESEARCH, 80(3), 215–223.
MeSH headings : Animals; Drosophila / anatomy & histology; Drosophila / genetics; Female; Genetic Variation; Male
TL;DR:
The pattern of genetic variation between sites was consistent with underlying heterogeneity of genetic mechanisms for response to the same environmental gradients between traits and sibling species, and the genetic architecture of bristle number at the level of variation within populations was very similar between species for the same bristle trait.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
13. Climate Action
(Web of Science)
15. Life on Land
(Web of Science)
Source: Web Of Science
Added: August 6, 2018
2000 journal article
Both naturally occurring insertions of transposable elements and intermediate frequency polymorphisms at the achaete-scute complex are associated with variation in bristle number in Drosophila melanogaster
Genetics, 154(3), 1255–1269.
Source: NC State University Libraries
Added: August 6, 2018
2000 journal article
Genotype-environment interaction for quantitative trait loci affecting life span in Drosophila melanogaster
Genetics, 154(1), 213–227.
Source: NC State University Libraries
Added: August 6, 2018
1999 journal article
Linkage disequilibrium mapping of molecular polymorphisms at the scabrous locus associated with naturally occurring variation in bristle number in Drosophila melanogaster
GENETICS RESEARCH, 74(3), 303–311.
MeSH headings : Animals; Chromosome Mapping; Drosophila Proteins; Drosophila melanogaster / anatomy & histology; Drosophila melanogaster / genetics; Female; Glycoproteins / genetics; Insect Proteins / genetics; Linkage Disequilibrium; Male; Phenotype; Polymorphism, Genetic; Quantitative Trait, Heritable
TL;DR:
Three sites in regulatory regions were associated with female-specific variation in abdominal bristle number, one of which was an SSCP site in the region of the gene associated with regulation of sca in embryonic abdominal segments.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
13. Climate Action
(Web of Science)
15. Life on Land
(Web of Science)
Source: Web Of Science
Added: August 6, 2018
1998 journal article
Candidate quantitative trait loci and naturally occurring phenotypic variation for bristle number in Drosophila melanogaster: The Delta-Hairless gene region
Genetics, 149(2), 983–998.
Source: NC State University Libraries
Added: August 6, 2018
1998 journal article
Genotype-environment interaction at quantitative trait loci affecting sensory bristle number in Drosophila melanogaster
Genetics, 149(4), 1883–1898.
Source: NC State University Libraries
Added: August 6, 2018
1998 journal article
Two sites in the Delta gene region contribute to naturally occurring variation in bristle number in Drosophila melanogaster
Genetics, 149(2), 999–1017.
Source: NC State University Libraries
Added: August 6, 2018
journal article
A transcriptional network associated with natural variation in Drosophila aggressive behavior
Edwards, A. C., Ayroles, J. F., Stone, E. A., Carbone, M. A., Lyman, R. F., & Mackay, T. F. C. Genome Biology, 10(7).
Source: NC State University Libraries
Added: August 6, 2018
journal article
Genetic architecture of abdominal pigmentation in Drosophila melanogaster
Dembeck, L. M., Huang, W., Magwire, M. M., Lawrence, F., Lyman, R. F., & Mackay, T. F. C. PLoS Genetics, 11(5).
Source: NC State University Libraries
Added: August 6, 2018
journal article
Genetic basis of transcriptome diversity in Drosophila melanogaster
Huang, W., Carbone, M. A., Magwire, M. M., Peiffer, J. A., Lyman, R. F., Stone, E. A., … Mackay, T. F. C. Proceedings of the National Academy of Sciences of the United States of America, 112(44), E6010–6019.
Source: NC State University Libraries
Added: August 6, 2018
journal article
Genetic variation in senescence marker protein-30 is associated with natural variation in cold tolerance in Drosophila
Clowers, K. J., Lyman, R. F., Mackay, T. F. C., & Morgan, T. J. Genetical Research, 92(2), 103–113.
Source: NC State University Libraries
Added: August 6, 2018
journal article
Genomic response to selection for postponed senescence in Drosophila
Wilson, R. H., Lai, C. Q., Lyman, R. F., & Mackay, T. F. C. Mechanisms of Ageing and Development, 134(3-4), 79–88.
Source: NC State University Libraries
Added: August 6, 2018
journal article
Natural variation in odorant recognition among odorant-binding proteins in Drosophila melanogaster
Wang, P., Lyman, R. F., Mackay, T. F. C., & Anholt, R. R. H. Genetics, 184(3), 759–767.
Source: NC State University Libraries
Added: August 6, 2018
journal article
Polygenic mutation in Drosophila melanogaster: Genotype x environment interaction for spontaneous mutations affecting bristle number
Mackay, T. F. C., & Lyman, R. F. Genetica, 102-103(1-6), 199–215.
Source: NC State University Libraries
Added: August 6, 2018
journal article
Spontaneous mutations and the origin and maintenance of quantitative genetic variation
Huang, W., Lyman, R. F., Lyman, R. A., Carbone, M. A., Harbison, S. T., Magwire, M. M., & Mackay, T. F. C. Elife, 5.
Source: NC State University Libraries
Added: August 6, 2018
journal article
The Drosophila melanogaster genetic reference panel
Mackay, T. F. C., Richards, S., Stone, E. A., Barbadilla, A., Ayroles, J. F., Zhu, D. H., … Carbone, M. A. Nature, 482(7384), 173–178.
Source: NC State University Libraries
Added: August 6, 2018
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