Rachel Gagliardi

College of Veterinary Medicine

Works (3)

Updated: April 23rd, 2025 18:59

2024 article

A NOVEL MATRIKINE STIMULATED EQUINE SYNOVIAL FIBROBLAST AND CHONDROCYTE CO-CULTURE MODEL OF OSTEOARTHRITIS: A PROPOSED ALTERNATIVE TO TRADITIONAL LPS AND IL-1B MODELS

Gagliardi, R., Loeser, R. F., & Schnabel, L. (2024, May 23). Osteoarthritis and Cartilage, Vol. 32, pp. 780–781.

By: R. Gagliardi*, R. Loeser & L. Schnabel* 

topics (OpenAlex): Osteoarthritis Treatment and Mechanisms; Bone Metabolism and Diseases; Spine and Intervertebral Disc Pathology
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2. Zero Hunger (OpenAlex)
Sources: Web Of Science, NC State University Libraries
Added: August 26, 2024

2024 journal article

Matrikine stimulation of equine synovial fibroblasts and chondrocytes results in an in vitro osteoarthritis phenotype

Journal of Orthopaedic Research, 43(2), 292–303.

By: R. Gagliardi n, D. Koch n, R. Loeser * & L. Schnabel n 

author keywords: equine; fibronectin fragments; in vitro; osteoarthritis
MeSH headings : Animals; Horses; Fibroblasts / metabolism; Osteoarthritis / metabolism; Chondrocytes / metabolism; Fibronectins / metabolism; Phenotype; Synovial Membrane / cytology; Synovial Membrane / metabolism; Cells, Cultured
topics (OpenAlex): Osteoarthritis Treatment and Mechanisms; Tendon Structure and Treatment; Veterinary Equine Medical Research
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Sources: Web Of Science, ORCID, NC State University Libraries, Crossref
Added: December 2, 2024

2020 article

The combination of mitogenic stimulation and DNA damage induces chondrocyte senescence

Copp, M. E., Flanders, M. C., Gagliardi, R., Gilbertie, J. M., Sessions, G. A., Chubinskaya, S., … Diekman, B. O. (2020, November 20). Osteoarthritis and Cartilage, Vol. 29, pp. 402–412.

By: M. Copp n, M. Flanders  n, R. Gagliardi n, J. Gilbertie n, G. Sessions *, S. Chubinskaya*, R. Loeser *, L. Schnabel n , B. Diekman n

author keywords: SA-beta-gal; DNA damage; Osteoarthritis; Aging; TGF- beta 1; bFGF
MeSH headings : Animals; Ankle Joint; Cartilage, Articular / cytology; Cartilage, Articular / drug effects; Cartilage, Articular / metabolism; Cellular Senescence / drug effects; Cellular Senescence / genetics; Chemokine CCL2 / drug effects; Chemokine CCL2 / genetics; Chondrocytes / drug effects; Chondrocytes / metabolism; Cyclin-Dependent Kinase Inhibitor p16 / drug effects; Cyclin-Dependent Kinase Inhibitor p16 / metabolism; DNA Damage / genetics; Fibroblast Growth Factor 2 / pharmacology; Gene Expression / drug effects; Histones / drug effects; Histones / metabolism; Horses; Humans; In Vitro Techniques; Inflammation / genetics; Insulin-Like Growth Factor Binding Protein 3 / drug effects; Insulin-Like Growth Factor Binding Protein 3 / genetics; Interleukin-6 / genetics; Matrix Metalloproteinase 13 / drug effects; Matrix Metalloproteinase 13 / genetics; Mitogens / pharmacology; Stifle; Transforming Growth Factor beta1 / pharmacology; beta-Galactosidase / drug effects; beta-Galactosidase / metabolism
topics (OpenAlex): Telomeres, Telomerase, and Senescence; Mesenchymal stem cell research; RNA Interference and Gene Delivery
TL;DR: Treatment of cartilage explants with mitogenic stimuli in the context of cellular damage reliably induces high levels of SA-β-gal activity and other senescence markers, which provides a physiologically relevant model system to investigate the mechanisms of senescences induction. (via Semantic Scholar)
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Sources: Web Of Science, ORCID, NC State University Libraries
Added: March 29, 2021

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