Rachel Gagliardi

College of Veterinary Medicine

Works (3)

Updated: December 11th, 2024 05:01

2024 article

A NOVEL MATRIKINE STIMULATED EQUINE SYNOVIAL FIBROBLAST AND CHONDROCYTE COCULTURE MODEL OF OSTEOARTHRITIS: A PROPOSED ALTERNATIVE TO TRADITIONAL LPS AND IL-1B MODELS

Gagliardi, R., Loeser, R. F., & Schnabel, L. (2024, June). OSTEOARTHRITIS AND CARTILAGE, Vol. 32, pp. 780–781.

By: R. Gagliardi*, R. Loeser & L. Schnabel*

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Source: Web Of Science
Added: August 26, 2024

2024 article

Matrikine stimulation of equine synovial fibroblasts and chondrocytes results in an in vitro osteoarthritis phenotype

Gagliardi, R., Koch, D. W., Loeser, R., & Schnabel, L. V. (2024, November 1). JOURNAL OF ORTHOPAEDIC RESEARCH.

By: R. Gagliardi n, D. Koch n, R. Loeser * & L. Schnabel n

author keywords: equine; fibronectin fragments; in vitro; osteoarthritis
Source: Web Of Science
Added: December 2, 2024

2020 journal article

The combination of mitogenic stimulation and DNA damage induces chondrocyte senescence

OSTEOARTHRITIS AND CARTILAGE, 29(3), 402–412.

By: M. Copp n, M. Flanders  n, R. Gagliardi n, J. Gilbertie n, G. Sessions *, S. Chubinskaya*, R. Loeser *, L. Schnabel n, B. Diekman n

author keywords: SA-beta-gal; DNA damage; Osteoarthritis; Aging; TGF- beta 1; bFGF
MeSH headings : Animals; Ankle Joint; Cartilage, Articular / cytology; Cartilage, Articular / drug effects; Cartilage, Articular / metabolism; Cellular Senescence / drug effects; Cellular Senescence / genetics; Chemokine CCL2 / drug effects; Chemokine CCL2 / genetics; Chondrocytes / drug effects; Chondrocytes / metabolism; Cyclin-Dependent Kinase Inhibitor p16 / drug effects; Cyclin-Dependent Kinase Inhibitor p16 / metabolism; DNA Damage / genetics; Fibroblast Growth Factor 2 / pharmacology; Gene Expression / drug effects; Histones / drug effects; Histones / metabolism; Horses; Humans; In Vitro Techniques; Inflammation / genetics; Insulin-Like Growth Factor Binding Protein 3 / drug effects; Insulin-Like Growth Factor Binding Protein 3 / genetics; Interleukin-6 / genetics; Matrix Metalloproteinase 13 / drug effects; Matrix Metalloproteinase 13 / genetics; Mitogens / pharmacology; Stifle; Transforming Growth Factor beta1 / pharmacology; beta-Galactosidase / drug effects; beta-Galactosidase / metabolism
TL;DR: Treatment of cartilage explants with mitogenic stimuli in the context of cellular damage reliably induces high levels of SA-β-gal activity and other senescence markers, which provides a physiologically relevant model system to investigate the mechanisms of senescences induction. (via Semantic Scholar)
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Added: March 29, 2021

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