Ricardo G. Vancini

Works (8)

Updated: July 14th, 2023 21:13

2016 journal article

Single-Site Glycoprotein Mutants Inhibit a Late Event in Sindbis Virus Assembly

JOURNAL OF VIROLOGY, 90(18), 8372–8380.

By: J. Magliocca n, R. Vancini n, R. Hernandez n & D. Brown n

MeSH headings : Animals; Cells, Cultured; Cricetinae; Membrane Glycoproteins / genetics; Membrane Glycoproteins / metabolism; Microscopy, Electron; Mutant Proteins / genetics; Mutant Proteins / metabolism; Mutation, Missense; Point Mutation; Sequence Deletion; Sindbis Virus / genetics; Sindbis Virus / physiology; Sindbis Virus / ultrastructure; Suppression, Genetic; Temperature; Viral Envelope Proteins / genetics; Viral Envelope Proteins / metabolism; Viral Load; Virion / ultrastructure; Virus Assembly; Virus Cultivation; Virus Release
TL;DR: It is concluded that H230 is essential for the assembly of complete infectious Sindbis virus virions and that the presence of an amino acid at E2 position 209 is required for complete budding of Sind Bis virus particles although several different amino acids can be at this location without affecting the titer. (via Semantic Scholar)
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Source: Web Of Science
Added: August 6, 2018

2016 journal article

The role of the vacuolar ATPase in alphavirus replication.

Molecular Biology of the Cell, 27.

By: R. Schuchman, R. Vancini, A. Piper, D. Breuer, M. Ribeiro, D. Farreira, J. Magliocca, V. Emmerich, R. Hernandez, D. Brown

Source: NC State University Libraries
Added: August 6, 2018

2015 review

Alphavirus Entry into Host Cells

[Review of ]. Molecular basis of viral infection, 129, 33–62.

By: R. Vancini, R. Hernandez & D. Brown

Source: NC State University Libraries
Added: August 6, 2018

2013 journal article

Alphavirus Genome Delivery Occurs Directly at the Plasma Membrane in a Time- and Temperature-Dependent Process

JOURNAL OF VIROLOGY, 87(8), 4352–4359.

By: R. Vancini n, G. Wang n, D. Ferreira*, R. Hernandez  n & D. Brown n

MeSH headings : Animals; Cell Membrane / virology; Cells, Cultured; Cricetinae; Microscopy, Immunoelectron; RNA, Viral / metabolism; Sindbis Virus / physiology; Staining and Labeling / methods; Temperature; Time Factors; Virus Internalization
TL;DR: It is concluded that entry of alphaviruses is by direct penetration of cell plasma membranes through a pore structure formed by virus and, possibly, host proteins. (via Semantic Scholar)
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Source: Web Of Science
Added: August 6, 2018

2012 journal article

Flavivirus infection from mosquitoes in vitro reveals cell entry at the plasma membrane

VIROLOGY, 435(2), 406–414.

By: R. Vancini n, L. Kramer *, M. Ribeiro n, R. Hernandez n & D. Brown n

author keywords: Flavivirus; Virus entry; Mosquitoes; Electron microscopy
MeSH headings : Animals; Cell Membrane / ultrastructure; Cell Membrane / virology; Chlorocebus aethiops; Culex / virology; Culicidae / virology; Dengue Virus / pathogenicity; Dengue Virus / ultrastructure; Flavivirus / pathogenicity; Microscopy, Electron; Vero Cells / virology; Virus Internalization; West Nile virus / pathogenicity; West Nile virus / ultrastructure
TL;DR: The results show that Dengue and West Nile viruses may infect cells by a mechanism that involves direct penetration of the host cell plasma membrane as proposed for alphaviruses. (via Semantic Scholar)
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Source: Web Of Science
Added: August 6, 2018

2011 journal article

Alphavirus adsorption to mosquito cells as viewed by freeze fracture immunolabeling

VIROLOGY, 415(2), 132–140.

By: J. Kononchik n, R. Vancini n & D. Brown n

author keywords: Alphavirus; Cell penetration; Insect cells; Freeze-fracture; Electron microscopy
MeSH headings : Adsorption; Alphavirus / chemistry; Alphavirus / physiology; Alphavirus / ultrastructure; Animals; Cell Membrane / chemistry; Cell Membrane / ultrastructure; Cell Membrane / virology; Cells, Cultured; Culicidae / virology; Freeze Fracturing / methods; Immunohistochemistry / methods
TL;DR: Using freeze-fracture replicas, thin-sections and antibody labeling the data suggest that the intramembrane particles associated with SV may be part of the pore structure consisting of virus proteins and cell receptor. (via Semantic Scholar)
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Source: Web Of Science
Added: August 6, 2018

2011 journal article

Structural mutants of dengue virus 2 transmembrane domains exhibit host-range phenotype

VIROLOGY JOURNAL, 8.

By: K. Smith *, K. Nanda *, C. Spears *, M. Ribeiro n, R. Vancini n, A. Piper n, G. Thomas*, M. Thomas*, D. Brown n, R. Hernandez n

MeSH headings : Aedes; Amino Acid Sequence; Animals; Antibodies, Neutralizing / blood; Antibodies, Viral / blood; Cell Line; Dengue Virus / genetics; Dengue Virus / immunology; Dengue Virus / pathogenicity; Dengue Virus / physiology; Host Specificity; Mice; Mice, Inbred BALB C; Models, Molecular; Molecular Sequence Data; Mutant Proteins / genetics; Mutant Proteins / immunology; Mutant Proteins / metabolism; Sequence Deletion; Viral Envelope Proteins / genetics; Viral Envelope Proteins / immunology; Viral Envelope Proteins / metabolism
TL;DR: Novel host-range mutants of DV2 were created that have preferential growth in insect cells and impaired infectivity in mammalian cells and may be applied to many other insect-borne viral diseases for which no current effective therapies exist. (via Semantic Scholar)
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Source: Web Of Science
Added: August 6, 2018

2009 journal article

A high capacity Alphavirus heterologous gene delivery system

VIROLOGY, 390(2), 368–373.

By: K. Nanda n, R. Vancini n, M. Ribeiro n, D. Brown n & R. Hernandez n

author keywords: Alphavirus; Gene delivery; Morphological variants
MeSH headings : Animals; Cell Line; Cricetinae; Culicidae; Gene Transfer Techniques; Genetic Vectors; Microscopy, Electron, Transmission; Mutation, Missense; Sindbis Virus / genetics; Viral Proteins / genetics; Virion / ultrastructure
TL;DR: The first generation prototype larger vehicle, described here, carries a approximately 18 kb cDNA insert, however it is conceivable that RNA as large as 32 kb could be transcribed and packaged, and the resulting cargo containing virus particles are infectious. (via Semantic Scholar)
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Source: Web Of Science
Added: August 6, 2018

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