Works (40)
Updated: April 4th, 2024 07:37
2024 article
A novel <i>ITGA2B</i> double cytosine frameshift variant (c.1986_1987insCC) leads to Glanzmann's thrombasthenia in a cat
Rivas, V. N., Tan, A. W. K., Shaverdian, M., Nguyen, N. P., Wouters, J. R., Stern, J. A., & Li, R. H. L. (2024, March 1). JOURNAL OF VETERINARY INTERNAL MEDICINE, Vol. 3.
author keywords: congenital; feline; glycoprotein IIb/IIIa; macrothrombocytopenia; precision medicine; thrombopathia
TL;DR:
This study provides a small-volume, standardized, successful protocol for adequate platelet RNA isolation and subsequent molecular assessment of gene expression in cats and identified yet another variant that may be of utility for screening in the feline population.
(via Semantic Scholar)
onlinelibrary.wiley.com (publisher PDF)
Sources: Web Of Science, NC State University Libraries, ORCID
Added: March 8, 2024
2023 journal article
Case report: Disseminated intravascular coagulation in a dog following treatment with melarsomine for Dirofilaria immitis
Frontiers in Veterinary Science, 10, 1118798.
TL;DR:
This is the first report of documented disseminated intravascular coagulation following melarsomine treatment for D. immitis in a 9-year-old female intact pit bull-type dog and highlights a rare, but serious complication of adulticide therapy.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(OpenAlex)
Sources: Crossref, NC State University Libraries, ORCID
Added: December 10, 2023
2023 journal article
Circulating neutrophil extracellular traps in cats with hypertrophic cardiomyopathy and cardiogenic arterial thromboembolism
Journal of Veterinary Internal Medicine, 37(2), 490–502.
TL;DR:
Neutrophil extracellualr traps, especially citH3, are increased in cats with HCM and CATE and may serve as a novel therapeutic target and biomarker of thrombosis in catswith HCM.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(OpenAlex)
Sources: Crossref, NC State University Libraries, ORCID
Added: December 10, 2023
2023 journal article
Evaluation of autoantibodies to desmoglein-2 in dogs with and without cardiac disease
Scientific Reports, 13(1).
MeSH headings : Animals; Dogs; Arrhythmogenic Right Ventricular Dysplasia; Autoantibodies; Dog Diseases / metabolism; Heart Atria; Prospective Studies; Desmoglein 2 / immunology
TL;DR:
This prospective study is the first to evaluate dogs of various breeds and cardiac disease state for anti-desmoglein-2 antibodies and found correlation with some measures of disease severity requires further study with larger populations.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
Sources: ORCID, Crossref, NC State University Libraries, Web Of Science
Added: June 26, 2023
2023 journal article
Evaluation of thrombin generation in dogs administered clopidogrel
Frontiers in Veterinary Science, 10.
author keywords: coagulation; platelet inhibitory; antithrombotic; therapeutic monitoring; canine
TL;DR:
Thrombin generation performed on platelet poor plasma may not be a useful antiplatelet monitoring tool in dogs, despite concomitant changes in TEG-PM variables consistent with platelet inhibition.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
1. No Poverty
(OpenAlex)
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, NC State University Libraries, ORCID, Crossref
Added: September 11, 2023
2023 journal article
Naturally occurring canine laminopathy leading to a dilated and fibrosing cardiomyopathy in the Nova Scotia Duck Tolling Retriever
Scientific Reports, 13(1), 19077.
TL;DR:
Pedigree analysis in the NSDTR and functional evaluation of heterozygotes is consistent with a predominantly recessive mode of inheritance and possibly low penetrance in heterozygotes in contrast to people, where most pathogenic LMNA variants are dominantly inherited.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(OpenAlex)
Sources: Crossref, NC State University Libraries, ORCID
Added: December 10, 2023
2023 journal article
Preventing Cardiogenic Thromboembolism in Cats: Literature Gaps, Rational Recommendations, and Future Therapies
Veterinary Clinics of North America: Small Animal Practice, 53(6), 1309–1323.
author keywords: Immunothrombosis; Hypertrophic cardiomyopathy; Platelet priming; Neutrophil extracellular traps; Thromboprophylaxis
TL;DR:
This comprehensive review aims to summarize existing literature on pathophysiology, clinical diagnosis, and current recommendations on the prevention and treatment of CATE and identifies and describes knowledge gaps and research priorities in the roles of immunothrombosis and procoagulant platelets in the pathogenesis of Cate.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(OpenAlex)
Sources: ORCID, Crossref, NC State University Libraries, Web Of Science
Added: December 13, 2023
2023 journal article
Synergistic inhibitory effects of clopidogrel and rivaroxaban on platelet function and platelet‐dependent thrombin generation in cats
Journal of Veterinary Internal Medicine, 37(4), 1390–1400.
TL;DR:
Treatment combining clopidogrel and rivaroxaban (DAT) safely decreases platelet activation, platelet response to agonists, and thrombin generation in feline platelets more effectively than monotherapy with either clopIDogrel or rivroxaban.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(OpenAlex)
Sources: Crossref, NC State University Libraries, ORCID
Added: December 10, 2023
2022 journal article
2022 Update of the Consensus on the Rational Use of Antithrombotics and Thrombolytics in Veterinary Critical Care (CURATIVE) Domain 1‐ Defining populations at risk
Journal of Veterinary Emergency and Critical Care, 32(3), 289–314.
author keywords: arrhythmias; heartworm disease; protein-losing enteropathy; vascular devices
MeSH headings : Adrenocortical Hyperfunction / drug therapy; Adrenocortical Hyperfunction / veterinary; Anemia, Hemolytic, Autoimmune / drug therapy; Anemia, Hemolytic, Autoimmune / veterinary; Animals; Cat Diseases / drug therapy; Cat Diseases / epidemiology; Cats; Consensus; Critical Care; Dirofilariasis; Dog Diseases / drug therapy; Dog Diseases / epidemiology; Dogs; Fibrinolytic Agents / therapeutic use; Protein-Losing Enteropathies / drug therapy; Protein-Losing Enteropathies / veterinary; Risk Factors; Sepsis / veterinary; Thrombosis / veterinary
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Crossref, NC State University Libraries, ORCID, Web Of Science
Added: May 16, 2022
2022 journal article
Clinical, Diagnostic, and Imaging Findings in Three Juvenile Dogs With Paraspinal Hyperesthesia or Myelopathy as a Consequence of Hemophilia A: A Case Report
Frontiers in Veterinary Science, 9, 871029.
TL;DR:
Hemophilia A should be considered as a differential in any young dog presenting with an acute onset of hyperesthesia with or without neurologic deficits and should be prioritized in young male dogs that have other evidence of hemorrhage on physical exam.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(OpenAlex)
Sources: Crossref, NC State University Libraries, ORCID
Added: December 10, 2023
2022 journal article
Platelet Priming and Activation in Naturally Occurring Thermal Burn Injuries and Wildfire Smoke Exposure Is Associated With Intracardiac Thrombosis and Spontaneous Echocardiographic Contrast in Feline Survivors
Frontiers in Veterinary Science, 9.
author keywords: hypercoagulability; primary hemostasis; particulate matter <2; 5 mu m (PM) 2.5; hypertrophic cardiomyopathy (HCM); thromboembolism
TL;DR:
This is the first study reporting the significant association between platelet priming and intracardiac thrombosis in domestic cats with naturally occurring wildfire-related injuries and smoke inhalation.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: ORCID, Crossref, NC State University Libraries, Web Of Science
Added: August 8, 2022
2021 journal article
A genetic polymorphism in P2RY(1) impacts response to clopidogrel in cats with hypertrophic cardiomyopathy
SCIENTIFIC REPORTS, 11(1).
MeSH headings : Animals; Cardiomyopathy, Hypertrophic / drug therapy; Cardiomyopathy, Hypertrophic / genetics; Cardiomyopathy, Hypertrophic / pathology; Cardiomyopathy, Hypertrophic / veterinary; Cats; Clopidogrel / adverse effects; Clopidogrel / pharmacology; Genetic Predisposition to Disease; Genotype; Humans; Platelet Activation / drug effects; Platelet Aggregation / drug effects; Platelet Aggregation Inhibitors / adverse effects; Platelet Aggregation Inhibitors / pharmacology; Polymorphism, Single Nucleotide / genetics; Receptors, Purinergic P2Y1 / genetics
TL;DR:
It is demonstrated that a genetic polymorphism in the P2RY1 gene altered response to clopidogrel therapy and suggests that clinicians may consider alternative or additional thromboprophylactic therapy in cats with the P 2RY1:A236G variant.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
Sources: ORCID, Web Of Science, NC State University Libraries
Added: July 19, 2021
2021 journal article
Dual therapy with clopidogrel and rivaroxaban in cats with thromboembolic disease
Journal of Feline Medicine and Surgery, 24(4), 277–283.
TL;DR:
Dual antithrombotic therapy with clopidogrel and rivaroxaban resulted in a low reported incidence of adverse events and effective thromboprophylaxis was achieved in cats with intracardiac thrombi or SEC.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(OpenAlex)
Sources: Crossref, NC State University Libraries, ORCID
Added: December 10, 2023
2021 journal article
Lipopolysaccharide-Activated Canine Platelets Upregulate High Mobility Group Box-1 via Toll-Like Receptor 4
Frontiers in Veterinary Science Experimental and Diagnostic Pathology, 8, 674678.
TL;DR:
It is discovered that upregulation of platelet-derived HMGB1 occurs as a result of thrombin or TLR4-mediated activation in dogs, and this expression was found to be most prominent in platelets that had undergone alpha-granule secretion.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(OpenAlex)
Sources: ORCID, NC State University Libraries, NC State University Libraries
Added: December 13, 2023
2021 journal article
Mining the 99 Lives Cat Genome Sequencing Consortium database implicates genes and variants for the Ticked locus in domestic cats (Felis catus)
Animal Genetics, 52(3), 321—332.
TL;DR:
Bioinformatic and molecular modeling analysis suggests that changes in the Ticked locus disrupt a key disulfide bond in the Dkk4 cysteine‐rich domain 1 or DKK4 signal peptide cleavage respectively.
(via Semantic Scholar)
Source: ORCID
Added: December 13, 2023
2021 journal article
Multi-omic analyses in Abyssinian cats with primary renal amyloid deposits
Scientific Reports, 11(1).
MeSH headings : Amyloidogenic Proteins / metabolism; Amyloidosis, Familial / genetics; Amyloidosis, Familial / metabolism; Amyloidosis, Familial / veterinary; Animals; Cat Diseases / genetics; Cat Diseases / metabolism; Cats / genetics; Cats / metabolism; Genetic Variation / genetics; Kidney / metabolism; Kidney Diseases / genetics; Kidney Diseases / metabolism; Kidney Diseases / veterinary; MicroRNAs; Proteomics; Whole Genome Sequencing
TL;DR:
The general conclusions are that the familial amyloid renal form in Abyssinians is not a simple monogenic trait and is a mix of proteins codified by wild-type genes, and the form is biochemically classifiable as AA amyloidsosis.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: ORCID, Crossref, NC State University Libraries, Web Of Science
Added: May 24, 2021
2021 journal article
Neutrophil extracellular traps in feline cardiogenic arterial thrombi: a pilot study
Journal of Feline Medicine and Surgery, 24(6), 580–586.
TL;DR:
The variation in NET distribution within arterial thrombi may shed light on the pathogenesis of thrombus growth and may be due to possible neutrophil entrapment or variations in shear stress.
(via Semantic Scholar)
Sources: Crossref, NC State University Libraries, ORCID
Added: December 10, 2023
2021 article
Platelet Priming Following Naturally Occurring Thermal Burn Injuries And Wildfire Smoke Exposure is Associated with Intracardiac Thrombosis in Feline Survivors
TL;DR:
This is the first study reporting the significant association between platelet priming and intracardiac thrombosis in domestic cats with naturally occurring wildfire-related injuries and smoke inhalation.
(via Semantic Scholar)
Source: ORCID
Added: December 13, 2023
2020 journal article
A Deletion in GDF7 is Associated with a Heritable Forebrain Commissural Malformation Concurrent with Ventriculomegaly and Interhemispheric Cysts in Cats
Genes, 11(6), 672.
TL;DR:
A genetic test can be developed for use by cat breeders to eradicate this variant and emphasizes the importance of GDF7 in the neurodevelopmental process in the mammalian brain.
(via Semantic Scholar)
Sources: ORCID, Crossref, NC State University Libraries
Added: December 13, 2023
2020 journal article
Assessment of P2Y12 Inhibition by Clopidogrel in Feline Platelets Using Flow Cytometry Quantification of Vasodilator-Stimulated Phosphoprotein Phosphorylation
Frontiers in Veterinary Science, 7, 267.
TL;DR:
Flow cytometry analysis of P-VASP is effective at monitoring the inhibitory effects of clopidogrel on feline platelets, and platelet response to ADP was significantly attenuated after 7 days of clopsinogrel treatment.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(OpenAlex)
Sources: Crossref, NC State University Libraries, ORCID
Added: December 10, 2023
2020 journal article
Cats with thermal burn injuries from California wildfires show echocardiographic evidence of myocardial thickening and intracardiac thrombi
Scientific Reports, 10(1), 2648.
TL;DR:
The first time, cardiovascular and coagulation effects of thermal burn and smoke inhalation in cats are described for the first time.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(OpenAlex)
Sources: ORCID, Crossref, NC State University Libraries
Added: December 13, 2023
2020 journal article
Identification of Neutrophil Extracellular Traps in Paraffin-Embedded Feline Arterial Thrombi using Immunofluorescence Microscopy
Journal of Visualized Experiments, 3(157).
TL;DR:
A standardized method to identify and quantify NETs in cardiogenic arterial thrombi in cats will advance the understanding of their pathological role in CATE and offers new insights into the pathophysiology of this complex condition.
(via Semantic Scholar)
Sources: ORCID, Crossref, NC State University Libraries
Added: December 13, 2023
2020 journal article
Mutations in the Kinesin-2 Motor KIF3B Cause an Autosomal-Dominant Ciliopathy
The American Journal of Human Genetics, 106(6), 893–904.
TL;DR:
The genetic, cell-based, and in vivo modeling data delineate an autosomal-dominant syndromic retinal ciliopathy in humans and suggest that multiple KIF3B pathomechanisms can impair kinesin-driven ciliary transport in the photoreceptor.
(via Semantic Scholar)
Sources: ORCID, Crossref, NC State University Libraries
Added: December 13, 2023
2020 journal article
Precision medicine identifies a pathogenic variant of the <scp><i>ITGA2B</i></scp> gene responsible for Glanzmann's thrombasthenia in a cat
Journal of Veterinary Internal Medicine, 34(6), 2438–2446.
TL;DR:
This novel ITGA2B variant and the associated phenotype closely resemble Glanzmann's thrombasthenia, which has never been reported in cats.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(OpenAlex)
Sources: ORCID, Crossref, NC State University Libraries
Added: December 13, 2023
2020 journal article
Werewolf, There Wolf: Variants in Hairless Associated with Hypotrichia and Roaning in the Lykoi Cat Breed
Genes, 11(6), 682.
TL;DR:
Comparison to the 99 Lives dataset of 194 non-lykoi cats suggested two variants in the cat homolog for Hairless (HR: lysine demethylase and nuclear receptor corepressor) as candidate causal variants, and four additional loss of function HR variants likely causing the highly similar phenotypic hair coat across the diverse cats were identified.
(via Semantic Scholar)
Sources: ORCID, Crossref, NC State University Libraries
Added: December 13, 2023
2019 journal article
Canine platelets express functional Toll-like receptor-4: lipopolysaccharide-triggered platelet activation is dependent on adenosine diphosphate and thromboxane A2 in dogs
BMC Veterinary Research, 15(1), 245.
TL;DR:
It is discovered that dog platelets have variable TLR4 expression, which was upregulated following thrombin or ADP activation, which may contribute to hypercoagulability in clinical septic dogs.
(via Semantic Scholar)
Sources: ORCID, Crossref, NC State University Libraries
Added: December 13, 2023
2019 journal article
Clinical, metabolic, and genetic characterization of hereditary methemoglobinemia caused by cytochrome b<sub>5</sub> reductase deficiency in cats
Journal of Veterinary Internal Medicine, 33(6), 2725–2731.
TL;DR:
2 novel CYB5R3 variants were associated with methemoglobinemia using clinical, biochemical, genomics, and in silico protein studies, and the variant prevalence is unknown in the cat population.
(via Semantic Scholar)
Sources: Crossref, NC State University Libraries
Added: December 17, 2023
2019 journal article
Consensus on the Rational Use of Antithrombotics in Veterinary Critical Care (CURATIVE): Domain 2—Defining rational therapeutic usage
Journal of Veterinary Emergency and Critical Care, 29(1), 49–59.
TL;DR:
Standardized, systematic evaluation of the literature, categorization of relevant articles according to level of evidence (LOE) and quality (Good, Fair, or Poor), and development of consensus on conclusions via a Delphi-style survey for application of the concepts to clinical practice are undertaken.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
1. No Poverty
(OpenAlex)
Sources: Crossref, NC State University Libraries, ORCID
Added: December 10, 2023
2019 journal article
Neutrophil-Extracellular Traps, Cell-Free DNA, and Immunothrombosis in Companion Animals: A Review
Veterinary Pathology, 57(1), 6–23.
TL;DR:
The present understanding of these phenomena and the mechanisms of extracellular trap formation are outlined, and what therapeutic options these insights might present to clinicians in the future are speculated on.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(OpenAlex)
Sources: ORCID, Crossref, NC State University Libraries
Added: December 10, 2023
2018 journal article
<em>In Vitro</em> Canine Neutrophil Extracellular Trap Formation: Dynamic and Quantitative Analysis by Fluorescence Microscopy
Journal of Visualized Experiments, 8(138).
TL;DR:
This technique is a specific assay to evaluate the in vitro capacity of canine neutrophils to undergo NETosis and objectively quantify NET formation and citH3 expression using fluorescence microscopy.
(via Semantic Scholar)
Sources: ORCID, Crossref, NC State University Libraries
Added: December 13, 2023
2018 journal article
A Comparative Review of Neutrophil Extracellular Traps in Sepsis
Frontiers in Veterinary Science, 5, 291.
TL;DR:
There is increasing evidence in human and veterinary medicine suggesting that NETs play a crucial role in the pathogenesis of intravascular thrombosis and multiple organ failure in sepsis, and the use of novel therapies to target NET components shows promising results in murine septic models.
(via Semantic Scholar)
Sources: Crossref, NC State University Libraries, ORCID
Added: December 10, 2023
2018 journal article
A novel approach to identifying and quantifying neutrophil extracellular trap formation in septic dogs using immunofluorescence microscopy
BMC Veterinary Research, 14(1), 210.
TL;DR:
Immunofluorescence microscopy could be a useful tool for the study of NETs in dogs with clinical sepsis after identifying and quantifying neutrophil extracellular traps in cytology samples collected from septic dogs.
(via Semantic Scholar)
Sources: Crossref, NC State University Libraries, ORCID
Added: December 10, 2023
2018 journal article
Nonsynonymous single nucleotide polymorphisms in candidate genes <i>P2<scp>RY</scp>1</i>,<i> P2<scp>RY</scp>12</i> and <i><scp>CYP</scp>2C19</i> for clopidogrel efficacy in cats
Animal Genetics, 49(4), 356–357.
Sources: ORCID, Crossref, NC State University Libraries
Added: December 13, 2023
2017 journal article
Lipopolysaccharide-induced neutrophil extracellular trap formation in canine neutrophils is dependent on histone H3 citrullination by peptidylarginine deiminase
Veterinary Immunology and Immunopathology, 193-194, 29–37.
Sources: Crossref, NC State University Libraries, ORCID
Added: December 10, 2023
2016 journal article
Evaluation of platelet function using multiple electrode platelet aggregometry in dogs with septic peritonitis
Journal of Veterinary Emergency and Critical Care, 26(5), 630–638.
TL;DR:
Circulating platelets from dogs with septic peritonitis have diminished aggregation in response to multiple platelet agonists, and MEPA may serve as an assessment tool for illness severity in this patient population.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(OpenAlex)
Sources: Crossref, NC State University Libraries, ORCID
Added: December 10, 2023
2016 journal article
Platelet Activation and Clopidogrel Effects on ADP-Induced Platelet Activation in Cats with or without the A31P Mutation in MYBPC3
Journal of Veterinary Internal Medicine, 30(5), 1619–1629.
TL;DR:
Cats with A31P mutation had increased platelet activation relative to the variable response seen in wild‐type cats, and clopidogrel treatment attenuated ADP‐induced P‐selectin expression and platelet aggregation.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(OpenAlex)
Sources: ORCID, Crossref, NC State University Libraries
Added: December 13, 2023
2013 journal article
Acute kidney injury in dogs and cats 1. Pathogenesis and diagnosis
In Practice, 35(5), 253–264.
TL;DR:
The pathophysiology and diagnosis of acute kidney injury in dogs and cats and the treatment, recovery and prognosis associated with AKI are reviewed.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(OpenAlex)
Sources: Crossref, NC State University Libraries
Added: December 17, 2023
2013 journal article
Acute kidney injury in dogs and cats 2. Management, treatment and outcome
In Practice, 35(6), 302–316.
TL;DR:
This article considers both specific therapy and general supportive treatment in dogs and cats with AKI, which is a commonly encountered emergency in small animal practice.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(OpenAlex)
Sources: Crossref, NC State University Libraries
Added: December 10, 2023
2006 journal article
Effects of indwelling nasogastric intubation on gastric emptying of a liquid marker in horses
American Journal of Veterinary Research, 67(7), 1100–1104.
TL;DR:
Results indicated that indwelling nasogastric intubation has a delaying effect on the gastric emptying rate of liquids, and Veterinarians should consider the potential for delayed gastrics emptying when placing and maintaining an indweller tube for an extended period of time after surgery.
(via Semantic Scholar)
Sources: ORCID, Crossref, NC State University Libraries
Added: December 13, 2023
2006 journal article
Postoperative effects of anesthesia and surgery on resting energy expenditure in horses as measured by indirect calorimetry
Canadian Journal of Veterinary Research, 70(4), 257–262. https://www.ncbi.nlm.nih.gov/pmc/articles/pmid/17042377/?tool=EBI
Sources: ORCID, NC State University Libraries
Added: December 13, 2023
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