@article{garetz_mitchell_parker_moore_rosen_giordani_muzumdar_paruthi_elden_willging_et al._2015, title={Quality of Life and Obstructive Sleep Apnea Symptoms After Pediatric Adenotonsillectomy}, volume={135}, ISSN={["1098-4275"]}, DOI={10.1542/peds.2014-0620}, abstractNote={ BACKGROUND AND OBJECTIVES: Data from a randomized, controlled study of adenotonsillectomy for obstructive sleep apnea syndrome (OSAS) were used to test the hypothesis that children undergoing surgery had greater quality of life (QoL) and symptom improvement than control subjects. The objectives were to compare changes in validated QoL and symptom measurements among children randomized to undergo adenotonsillectomy or watchful waiting; to determine whether race, weight, or baseline OSAS severity influenced changes in QoL and symptoms; and to evaluate associations between changes in QoL or symptoms and OSAS severity. METHODS: Children aged 5 to 9.9 years with OSAS (N = 453) were randomly assigned to undergo adenotonsillectomy or watchful waiting with supportive care. Polysomnography, the Pediatric Quality of Life inventory, the Sleep-Related Breathing Scale of the Pediatric Sleep Questionnaire, the 18-item Obstructive Sleep Apnea QoL instrument, and the modified Epworth Sleepiness Scale were completed at baseline and 7 months. Changes in the QoL and symptom surveys were compared between arms. Effect modification according to race and obesity and associations between changes in polysomnographic measures and QoL or symptoms were examined. RESULTS: Greater improvements in most QoL and symptom severity measurements were observed in children randomized to undergo adenotonsillectomy, including the parent-completed Pediatric Quality of Life inventory (effect size [ES]: 0.37), the 18-item Obstructive Sleep Apnea QoL instrument (ES: –0.93), the modified Epworth Sleepiness Scale score (ES: –0.42), and the Sleep-Related Breathing Scale of the Pediatric Sleep Questionnaire (ES: –1.35). Effect modification was not observed by obesity or baseline severity but was noted for race in some symptom measures. Improvements in OSAS severity explained only a small portion of the observed changes. CONCLUSIONS: Adenotonsillectomy compared with watchful waiting resulted in significantly more improvements in parent-rated generic and OSAS-specific QoL measures and OSAS symptoms. }, number={2}, journal={PEDIATRICS}, author={Garetz, Susan L. and Mitchell, Ron B. and Parker, Portia D. and Moore, Renee H. and Rosen, Carol L. and Giordani, Bruno and Muzumdar, Hiren and Paruthi, Shalini and Elden, Lisa and Willging, Paul and et al.}, year={2015}, month={Feb}, pages={E477–E486} } @article{mitchell_garetz_moore_rosen_marcus_katz_arens_chervin_paruthi_amin_et al._2015, title={The use of clinical parameters to predict obstructive sleep apnea syndrome severity in children the childhood adenotonsillectomy (CHAT) study randomized clinical trial}, volume={141}, number={2}, journal={Jama Otolaryngology-Head & Neck Surgery}, author={Mitchell, R. B. and Garetz, S. and Moore, R. H. and Rosen, C. L. and Marcus, C. L. and Katz, E. S. and Arens, R. and Chervin, R. D. and Paruthi, S. and Amin, R. and et al.}, year={2015}, pages={130–136} } @article{vetter_wadden_teff_khan_carvajal_ritter_moore_chittams_iagnocco_murayama_et al._2015, title={GLP-1 plays a limited role in improved glycemia shortly after Roux-en-Y gastric bypass: A comparison with intensive lifestyle modification}, volume={64}, DOI={10.2337/db14-0558}, abstractNote={Rapid glycemic improvements following Roux-en-Y gastric bypass (RYGB) are frequently attributed to the enhanced GLP-1 response, but causality remains unclear. To determine the role of GLP-1 in improved glucose tolerance after surgery, we compared glucose and hormonal responses to a liquid meal test in 20 obese participants with type 2 diabetes mellitus who underwent RYGB or nonsurgical intensive lifestyle modification (ILM) (n = 10 per group) before and after equivalent short-term weight reduction. The GLP-1 receptor antagonist exendin(9–39)-amide (Ex-9) was administered, in random order and in double-blinded fashion, with saline during two separate visits after equivalent weight loss. Despite the markedly exaggerated GLP-1 response after RYGB, changes in postprandial glucose and insulin responses did not significantly differ between groups, and glucagon secretion was paradoxically augmented after RYGB. Hepatic insulin sensitivity also increased significantly after RYGB. With Ex-9, glucose tolerance deteriorated similarly from the saline condition in both groups, but postprandial insulin release was markedly attenuated after RYGB compared with ILM. GLP-1 exerts important insulinotropic effects after RYGB and ILM, but the enhanced incretin response plays a limited role in improved glycemia shortly after surgery. Instead, enhanced hepatic metabolism, independent of GLP-1 receptor activation, may be more important for early postsurgical glycemic improvements.}, number={2}, journal={Diabetes}, author={Vetter, M. L. and Wadden, T. A. and Teff, K. L. and Khan, Z. F. and Carvajal, R. and Ritter, S. and Moore, R. H. and Chittams, J. L. and Iagnocco, A. and Murayama, K. and et al.}, year={2015}, pages={434–446} } @article{katz_moore_rosen_mitchell_amin_arens_muzumdar_chervin_marcus_paruthi_et al._2014, title={Growth After Adenotonsillectomy for Obstructive Sleep Apnea: An RCT}, volume={134}, ISSN={["1098-4275"]}, DOI={10.1542/peds.2014-0591}, abstractNote={ BACKGROUND AND OBJECTIVES: Adenotonsillectomy for obstructive sleep apnea syndrome (OSAS) may lead to weight gain, which can have deleterious health effects when leading to obesity. However, previous data have been from nonrandomized uncontrolled studies, limiting inferences. This study examined the anthropometric changes over a 7-month interval in a randomized controlled trial of adenotonsillectomy for OSAS, the Childhood Adenotonsillectomy Trial. METHODS: A total of 464 children who had OSAS (average apnea/hypopnea index [AHI] 5.1/hour), aged 5 to 9.9 years, were randomized to Early Adenotonsillectomy (eAT) or Watchful Waiting and Supportive Care (WWSC). Polysomnography and anthropometry were performed at baseline and 7-month follow-up. Multivariable regression modeling was used to predict the change in weight and growth indices. RESULTS: Interval increases in the BMI z score (0.13 vs 0.31) was observed in both the WWSC and eAT intervention arms, respectively, but were greater with eAT (P < .0001). Statistical modeling showed that BMI z score increased significantly more in association with eAT after considering the influences of baseline weight and AHI. A greater proportion of overweight children randomized to eAT compared with WWSC developed obesity over the 7-month interval (52% vs 21%; P < .05). Race, gender, and follow-up AHI were not significantly associated with BMI z score change. CONCLUSIONS: eAT for OSAS in children results in clinically significant greater than expected weight gain, even in children overweight at baseline. The increase in adiposity in overweight children places them at further risk for OSAS and the adverse consequences of obesity. Monitoring weight, nutritional counseling, and encouragement of physical activity should be considered after eAT for OSAS. }, number={2}, journal={PEDIATRICS}, author={Katz, Eliot S. and Moore, Renee H. and Rosen, Carol L. and Mitchell, Ron B. and Amin, Raouf and Arens, Raanan and Muzumdar, Hiren and Chervin, Ronald D. and Marcus, Carole L. and Paruthi, Shalini and et al.}, year={2014}, month={Aug}, pages={282–289} } @article{kral_moore_compher_2015, title={Maternal Concern about Child Weight in a Study of Weight-Discordant Siblings}, volume={32}, ISSN={["1525-1446"]}, DOI={10.1111/phn.12119}, abstractNote={AbstractObjectiveThis study examined concern about child weight in mothers of weight‐discordant siblings and determined the accuracy of maternal self‐report versus measured child height, weight, and corresponding body mass index (BMI; kg/m2) z‐score.Design and SampleDiscordant sibling design. Forty‐seven mothers of 5‐ to 12‐year‐old, weight‐discordant siblings.MeasuresMothers self‐reported their concern about child weight for each child separately and for a subset of children, self‐reported their heights and weights. Siblings' height, weight, waist circumference, and adiposity were measured.ResultsThe majority (83%) of mothers expressed concern about their overweight/obese child's weight and 20% of mothers expressed concern about their normal‐weight child's weight (p < .001). Difference scores in maternal concern about child weight were positively associated with difference scores in sibling BMI z‐score (r = 0.42; p = .01) and percent body fat (r = 0.56; p < .001). For overweight/obese children only, maternal‐reported child heights and weights were significantly lower compared to the measured values (p < .03).ConclusionsOne fifth of mothers of weight‐discordant siblings were unconcerned about their overweight/obese child's weight and for overweight/obese children only, mothers tended to underreport children's height and weight. Mothers' concern for their overweight/obese child's weight was greater for sibling pairs who were more discordant in their weight.}, number={2}, journal={PUBLIC HEALTH NURSING}, author={Kral, Tanja V. E. and Moore, Renee H. and Compher, Charlene W.}, year={2015}, pages={132–142} } @article{kral_remiker_strutz_moore_2014, title={Role of Child Weight Status and the Relative Reinforcing Value of Food in Children's Response to Portion Size Increases}, volume={22}, ISSN={["1930-739X"]}, DOI={10.1002/oby.20757}, abstractNote={ObjectiveFood portion size is an important determinant of intake in children. It remains unknown if children's weight status and relative reinforcing value of food (RRVF) interact with portion size to affect intake.MethodsIn a randomized crossover design, 25 normal‐weight and 25 obese children, ages 8‐10 years, consumed dinner once a week for 3 weeks. At each dinner, the same meal was served, but the portion size of all foods (chicken nuggets, hash browns, ketchup, green beans, brownies) and a sugar‐sweetened beverage (fruit punch) varied across conditions (100, 150, and 200%). Children's RRVF was assessed using a behavioral choice task.ResultsThere was a significant main effect of portion size condition (P = 0.003) and weight status (P = 0.0005) and a nonsignificant trend for a portion size‐by‐weight status interaction (P = 0.108) on intake. Mean intakes across conditions (100, 150, and 200%) were 801 ± 57, 964 ± 58, and 873 ± 57 kcal for normal‐weight children and 1041 ± 57, 1129 ± 57, and 1210 ± 57 kcal for obese children, respectively. Neither the main effect of RRVF status nor the condition‐by‐RRVF status interaction was significant (P > 0.48).ConclusionsEnvironments that offer large portions of palatable foods affect all children's intake irrespective of their weight status or how reinforcing they find food to be.}, number={7}, journal={OBESITY}, author={Kral, Tanja V. E. and Remiker, Adriane M. and Strutz, Erin M. and Moore, Renee H.}, year={2014}, month={Jul}, pages={1716–1722} } @article{marcus_moore_rosen_giordani_garetz_taylor_mitchell_amin_katz_arens_et al._2013, title={A randomized trial of adenotonsillectomy for childhood sleep apnea}, volume={368}, number={25}, journal={New England Journal of Medicine}, author={Marcus, C. L. and Moore, R. H. and Rosen, C. L. and Giordani, B. and Garetz, S. L. and Taylor, G. and Mitchell, R. B. and Amin, R. and Katz, E. S. and Arens, R. and et al.}, year={2013}, pages={2366–2376} } @article{allison_studt_berkowitz_hesson_moore_dubroff_newberg_stunkard_2013, title={An open-label efficacy trial of escitalopram for night eating syndrome}, volume={14}, ISSN={["1873-7358"]}, DOI={10.1016/j.eatbeh.2013.02.001}, abstractNote={{"Label"=>"OBJECTIVE", "NlmCategory"=>"OBJECTIVE"} Night eating syndrome (NES) has become increasingly recognized as a disorder in need of effective treatments. Selective serotonin reuptake inhibitors have shown efficacy in previous trials, so we sought to expand our understanding of the efficacy of escitalopram in the current trial. {"Label"=>"METHOD", "NlmCategory"=>"METHODS"} Thirty-one adults with NES participated in a 12-week open-label trial of escitalopram. Outcome measures included the Night Eating Symptom Scale (NESS), percent of daily intake after the evening meal (% intake) and number of nocturnal ingestions/week (NI), weight, total awakenings/week, mood, and quality of life. Mixed-effects models were used to assess change over time. {"Label"=>"RESULTS", "NlmCategory"=>"RESULTS"} Significant reductions were observed from week 0 to week 12 for the NESS (30.2 to 15.2), % intake (46% to 17%), NI (5.8 to 1.2), weight (90.2 to 88.6 kg), awakenings (8.1 to 2.7), and BDI-II (12.1 to 7.7). Outcomes did not differ significantly by gender, age, race, or psychiatric co-morbidity status. Eighteen of 31 completed 12 weeks of treatment. {"Label"=>"DISCUSSION", "NlmCategory"=>"CONCLUSIONS"} This open-label trial of escitalopram showed significant reductions in symptoms associated with NES. Randomized controlled trials are warranted to test these findings. {"Label"=>"TRIAL REGISTRATION", "NlmCategory"=>"BACKGROUND"} clinicaltrials.gov identifier: NCT01401595.}, number={2}, journal={EATING BEHAVIORS}, author={Allison, Kelly C. and Studt, Stacia K. and Berkowitz, Robert I. and Hesson, Louise A. and Moore, Renee H. and Dubroff, Jacob G. and Newberg, Andrew and Stunkard, Albert J.}, year={2013}, month={Apr}, pages={199–203} } @article{volger_wadden_sarwer_moore_chittams_diewald_panigrahi_berkowitz_schmitz_vetter_2013, title={Changes in eating, physical activity and related behaviors in a primary care-based weight loss intervention}, volume={37}, journal={International Journal of Obesity}, author={Volger, S. and Wadden, T. A. and Sarwer, D. B. and Moore, R. H. and Chittams, J. and Diewald, L. K. and Panigrahi, E. and Berkowitz, R. I. and Schmitz, K. and Vetter, M. L.}, year={2013}, pages={S12–18} } @article{vetter_wadden_chittams_diewald_panigrahi_volger_sarwer_moore_2013, title={Effect of lifestyle intervention on cardiometabolic risk factors: Results of the POWER-UP trial}, volume={37}, journal={International Journal of Obesity}, author={Vetter, M. L. and Wadden, T. A. and Chittams, J. and Diewald, L. K. and Panigrahi, E. and Volger, S. and Sarwer, D. B. and Moore, R. H.}, year={2013}, pages={S19–24} } @article{vetter_wadden_vinnard_moore_khan_volger_sarwer_faulconbridge_2013, title={Gender differences in the relationship between symptoms of depression and high-sensitivity CRP}, volume={37}, journal={International Journal of Obesity}, author={Vetter, M. L. and Wadden, T. A. and Vinnard, C. and Moore, R. H. and Khan, Z. and Volger, S. and Sarwer, D. B. and Faulconbridge, L. F.}, year={2013}, pages={S38–43} } @article{moore_sarwer_lavenberg_lane_evans_volger_wadden_2013, title={Relationship Between Sexual Function and Quality of Life in Obese Persons Seeking Weight Reduction}, volume={21}, ISSN={["1930-739X"]}, DOI={10.1002/oby.20398}, abstractNote={ObjectiveThis study investigated sexual functioning in persons with obesity and seeking weight loss, and the associations of sexual functioning with relevant demographic and clinical variables as well as quality of life were investigated.Design and MethodsParticipants were enrolled in a two‐year randomized clinical trial. Participants were obese and had at least two components of metabolic syndrome. Male and female sexual functioning was assessed by the International Index of Erectile Function (IIEF) and the Female Sexual Function Index (FSFI) respectively.ResultsThe rate of female sexual dysfunction was 29%. The rate of erectile dysfunction (ED) was 45%. Of the characteristics considered, FSD was associated with age (P = 0.002). ED was significantly associated with age and physical functioning (both P < 0.01).ConclusionsA large minority of patients with obesity reported sexual dysfunction. The occurrence of sexual dysfunction was associated with age, but, surprisingly, not weight‐related comorbidities. This may be the result of the nature of the study sample or the methods used to administer the questionnaires that assessed sexual functioning.}, number={10}, journal={OBESITY}, author={Moore, Renee H. and Sarwer, David B. and Lavenberg, Jeffrey A. and Lane, Ilana B. and Evans, Joanna L. and Volger, Sheri and Wadden, Thomas A.}, year={2013}, month={Oct}, pages={1966–1974} } @article{xanthopoulos_moore_wadden_bishop-gilyard_gehrman_berkowitz_2013, title={The Association Between Weight Loss in Caregivers and Adolescents in a Treatment Trial of Adolescents With Obesity}, volume={38}, ISSN={["1465-735X"]}, DOI={10.1093/jpepsy/jst024}, abstractNote={OBJECTIVE The relationship between weight change in caregivers and their adolescents was evaluated following a randomized trial of lifestyle modification for adolescents, which included either a conventional diet or meal replacements. METHODS Adolescents (N = 113) had an M ± SD age of 15.0 ± 1.3 years (62% African American; 26% Caucasian, 12% other; 81% female) and body mass index of 37.1 ± 5.1 kg/m(2). RESULTS Mixed effects models yielded a significant association between percentage change in body mass index of caregivers and adolescents from baseline to months 4 and 12 (p = .01). When caregivers lost above the median (-1.67%) at month 4, their adolescents achieved a significantly greater loss at month 12 (-9.1 ± 1.3%) compared with adolescents whose caregivers lost less than the median (-4.3 ± 1.3%) (p = .003). CONCLUSION Engaging caregivers in their own weight loss efforts during adolescent weight loss treatment may improve adolescent weight loss.}, number={7}, journal={JOURNAL OF PEDIATRIC PSYCHOLOGY}, author={Xanthopoulos, Melissa S. and Moore, Renee H. and Wadden, Thomas A. and Bishop-Gilyard, Chanelle T. and Gehrman, Christine A. and Berkowitz, Robert I.}, year={2013}, month={Aug}, pages={766–774} } @misc{weber_moore_leonard_zemel_2013, title={The fat mass index: Why its height exponent should be 3 and not 2 Reply}, volume={98}, number={5}, journal={American Journal of Clinical Nutrition}, author={Weber, D. R. and Moore, R. H. and Leonard, M. B. and Zemel, B. S.}, year={2013}, pages={1368–1369} } @article{sarwer_moore_diewald_chittams_berkowitz_vetter_volger_wadden_2013, title={The impact of a primary care-based weight loss intervention on the quality of life}, volume={37}, journal={International Journal of Obesity}, author={Sarwer, D. B. and Moore, R. H. and Diewald, L. K. and Chittams, J. and Berkowitz, R. I. and Vetter, M. and Volger, S. and Wadden, T. A.}, year={2013}, pages={S25–30} }