Randy Lynn Jirtle

Works (14)

Updated: May 13th, 2024 08:14

2024 journal article

DNA methylation of imprint control regions associated with Alzheimer's disease in non-Hispanic Blacks and non-Hispanic Whites

CLINICAL EPIGENETICS, 16(1).

By: S. Cevik  n, D. Skaar n , D. Jima n, A. Liu *, T. Ostbye *, H. Whitson *, R. Jirtle n, C. Hoyo n , A. Planchart n 

author keywords: Alzheimer's disease; Epigenetics; Imprint control regions; DNA methylation; Computational analysis
UN Sustainable Development Goal Categories
Sources: Web Of Science, NC State University Libraries
Added: May 7, 2024

2022 article

Genomic map of candidate human imprint control regions: the imprintome

Jima, D. D., Skaar, D. A., Planchart, A., Motsinger-Reif, A., Cevik, S. E., Park, S. S., … Hoyo, C. (2022, June 25). EPIGENETICS, Vol. 6.

By: D. Jima n, D. Skaar n , A. Planchart n , A. Motsinger-Reif n, S. Cevik  n, S. Park n, M. Cowley n , F. Wright n ...

author keywords: Epigenetics; genomic imprinting; foetal origins; whole genome; methylation; imprint control regions
MeSH headings : Adult; Humans; Genomic Imprinting; DNA Methylation; Chromosome Mapping; Alleles; Genomics
TL;DR: This draft of the human imprintome will allow for the systematic determination of the role of early-acquired imprinting dysregulation in the pathogenesis of human diseases and developmental and behavioural disorders. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Sources: Web Of Science, NC State University Libraries, ORCID
Added: July 11, 2022

2022 article

The science of hope: an interview with Randy Jirtle

Jirtle, R. L. (2022, March 10). EPIGENOMICS.

By: R. Jirtle n

author keywords: agouti; epigenome; imprintome; radiation hormesis; transposable elements
MeSH headings : Animals; Disease Susceptibility; Epigenesis, Genetic; Epigenome; Epigenomics; Genomic Imprinting; Humans; Male; Mammals; Mice
TL;DR: Professor Randy Jirtle is known for his groundbreaking studies linking environmental exposures early in life to the development of adult diseases through changes in the epigenome and for determining the evolutionary origin of genomic imprinting in mammals. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Source: Web Of Science
Added: March 28, 2022

2021 journal article

Epigenetic Dysregulation of KCNK9 Imprinting and Triple-Negative Breast Cancer

CANCERS, 13(23).

By: D. Skaar n , E. Dietze*, J. Alva-Ornelas*, D. Ann *, D. Schones *, T. Hyslop *, C. Sistrunk *, C. Zalles* ...

author keywords: triple negative breast cancer; KCNK9; epigenetics; imprinting
TL;DR: Evidence is provided that hypomethylation of the KNCK9 DMR/TASK3 overexpression may serve as a marker of risk and a target for prevention of TNBC, particularly in African American women. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (Web of Science; OpenAlex)
Sources: Web Of Science, NC State University Libraries, ORCID
Added: January 10, 2022

2021 article

Memorial Tribute to Kelly H. Clifton IN MEMORY

Jirtle, R. L. (2021, February). RADIATION RESEARCH, Vol. 195, pp. 218–219.

By: R. Jirtle n

MeSH headings : History, 20th Century; History, 21st Century; Humans; Radiation Oncologists / history
TL;DR: Kelly Hardenbrook Clifton, Sr., Emeritus Professor of Human Oncology and Radiology at the University of Wisconsin School of Medicine and Public Health, died at the age of 93, Monday, August 24, 2020 at Capitol Lakes Memory Care in Madison, WI. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Source: Web Of Science
Added: March 15, 2021

2018 journal article

DNA methylation of imprinted gene control regions in the regression of low-grade cervical lesions

INTERNATIONAL JOURNAL OF CANCER, 143(3), 552–560.

By: A. Gomih *, J. Smith *, K. North *, M. Hudgens *, W. Brewster *, Z. Huang *, D. Skaar n , F. Valea * ...

author keywords: methylation; imprinted genes; cervical cancer; neoplasia; epigenetics; HPV
MeSH headings : Adult; Aged; Biopsy; CpG Islands; DNA Methylation; Disease Progression; Epigenesis, Genetic; Female; Genomic Imprinting; Humans; Middle Aged; Neoplasm Grading; Neoplasm Staging; Regulatory Sequences, Nucleic Acid; Uterine Cervical Neoplasms / epidemiology; Uterine Cervical Neoplasms / etiology; Uterine Cervical Neoplasms / genetics; Uterine Cervical Neoplasms / pathology; Young Adult
TL;DR: Altered methylation of imprinted IGF2AS and PEG10 DMRs may play a role in the natural history of CIN1, and further research on imprinted gene DMR methylation is warranted to determine its efficacy as a biomarker for cervical cancer screening. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (Web of Science; OpenAlex)
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018

2018 review

Enhancing and Extending Biological Performance and Resilience

[Review of ]. DOSE-RESPONSE, 16(3).

By: R. Leak *, E. Calabrese *, W. Kozumbo*, J. Gidday *, T. Johnson*, J. Mitchell *, C. Ozaki *, R. Wetzker * ...

author keywords: preconditioning; conditioning; adaptation; hormesis; stress; tolerance; biphasic; dose-response; U-shaped; J-shaped; fitness; endurance; epigenetics; dietary restriction; caloric restriction
TL;DR: A path forward is proposed for researchers hoping to optimize protocols that support human health and longevity, whether in civilians, soldiers, athletes, or the elderly patients, by recommending approaches to control and exploit endogenous defense mechanisms to enhance the structure and function of biological tissues. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Source: Web Of Science
Added: October 19, 2018

2018 article

Epigenetic Responses to Low Dose Ionizing Radiation

Jirtle, R. L. (2018, August 20). FREE RADICAL BIOLOGY AND MEDICINE, Vol. 124, pp. 559–559.

By: R. Jirtle n

TL;DR: This animal model has been used to demonstrate that nutritional and chemical toxicant exposures during early development induce persistent epigenetic changes at the Avy locus that result in alterations in coat color and adult disease susceptibility. (via Semantic Scholar)
UN Sustainable Development Goal Categories
2. Zero Hunger (OpenAlex)
Source: Web Of Science
Added: October 16, 2018

2017 journal article

An Extended n-h bond, driven by a conserved second-order interaction, orients the flavin n5 orbital in cholesterol oxidase

Scientific Reports, 7.

By: E. Golden, L. Yu, F. Meilleur, M. Blakeley, A. Duff, A. Karton, A. Vrielink

Source: NC State University Libraries
Added: August 6, 2018

2017 review

Non-genomic transmission of longevity between generations: potential mechanisms and evidence across species

[Review of ]. EPIGENETICS & CHROMATIN, 10.

By: A. Vaiserman *, A. Koliada * & R. Jirtle n

author keywords: Epigenetics; DNA methylation; Transgenerational inheritance; Aging; Age-associated disease; Longevity
MeSH headings : Animals; Epigenesis, Genetic; Evolution, Molecular; Gene Expression Regulation, Developmental; Humans; Longevity / genetics
TL;DR: Findings from animal models, including worms, insects, and rodents, and also from human studies are summarized, indicating that lifespan and longevity-associated characteristics can be transmitted across generations via non-genetic factors. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Source: Web Of Science
Added: August 6, 2018

2016 article

Environmentally Induced Alterations in the Epigenome Affecting Obesity and Cancer in Minority Populations

EPIGENETICS, ENERGY BALANCE, AND CANCER, pp. 109–146.

By: D. Skaar n , R. Jirtle n & C. Hoyo n 

author keywords: Obesity; Obesogen; Prostate cancer; Adenocarcinoma; Disparity; Epigenetic
TL;DR: Evidence for the influence of environmental exposures on obesity and how epigenetic alterations may contribute to cancers that disproportionately affect minority populations exhibit disparities in incidence and mortality are summarized in this chapter. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (Web of Science; OpenAlex)
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018

2015 journal article

Geographic clustering of elevated blood heavy metal levels in pregnant women

BMC PUBLIC HEALTH, 15(1).

By: K. King *, T. Darrah *, E. Money n , R. Meentemeyer n , R. Maguire n, M. Nye*, L. Michener*, A. Murtha * ...

author keywords: Cadmium; Lead; Mercury; Arsenic; Spatial analysis
MeSH headings : Adult; Arsenic / blood; Cadmium / blood; Female; Humans; Lead / blood; Maternal Exposure / statistics & numerical data; Mercury / blood; Metals, Heavy / blood; Pregnancy; Pregnancy Complications / blood; Pregnancy Complications / epidemiology; Prenatal Care / statistics & numerical data; Prenatal Exposure Delayed Effects / prevention & control; Rural Population / statistics & numerical data; United States / epidemiology; Urban Population / statistics & numerical data; Young Adult
TL;DR: Elevated blood concentrations of Cd and Pb are spatially clustered in this urban environment compared to the surrounding areas and cluster membership was associated with lower education levels and higher pre-pregnancy BMI. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Sources: Web Of Science, ORCID, NC State University Libraries
Added: August 6, 2018

2015 journal article

Lead Exposure during Early Human Development and DNA Methylation of Imprinted Gene Regulatory Elements in Adulthood

ENVIRONMENTAL HEALTH PERSPECTIVES, 124(5), 666–673.

By: Y. Li *, C. Xie *, S. Murphy *, D. Skaar n , M. Nye*, A. Vidal *, K. Cecil *, K. Dietrich* ...

MeSH headings : Cell Cycle Proteins / metabolism; Child Development / physiology; Child, Preschool; DNA Methylation; Environmental Exposure / statistics & numerical data; Environmental Pollutants / blood; Female; Humans; Infant; Infant, Newborn; Insulin-Like Growth Factor II / metabolism; Lead / blood; Male; Transcription Factors / metabolism; Tumor Suppressor Proteins / metabolism
TL;DR: Evidence is provided that early childhood lead exposure results in sex-dependent and gene-specific DNA methylation differences in the DMRs of PEG3, IGF2/H19, and PLAGL1/HYMAI in adulthood. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (Web of Science; OpenAlex)
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018

2014 journal article

The Agouti mouse: A biosensor for environmental epigenomics studies investigating the developmental origins of health and disease

Epigenomics, 6(5), 447–450.

By: R. Jirtle n

MeSH headings : Agouti Signaling Protein / genetics; Animals; Biosensing Techniques; Breeding; Epigenesis, Genetic; Epigenomics; Gene-Environment Interaction; Hair Color / genetics; Mice; Mice, Transgenic; Mutation; Phenotype
TL;DR: An increased interest in using the agouti viable yellow (A vy ) isogenic mouse for envi- ronmental epigenomic studies investigating the developmental origins of health and dis- ease is observed. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Source: NC State University Libraries
Added: August 6, 2018

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