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Machine learning reveals sex-specific 17β-estradiol-responsive expression patterns in white perch (Morone americana) plasma proteins. PROTEOMICS, 15(15), 2678–2690. https://doi.org/10.1002/pmic.201400606 Nguyen, D. M. N., Lipscomb, G. L., Schut, G. J., Vaccaro, B. J., Basen, M., Kelly, R. M., & Adams, M. W. W. (2016). Temperature-dependent acetoin production by Pyrococcus furiosus is catalyzed by a biosynthetic acetolactate synthase and its deletion improves ethanol production. METABOLIC ENGINEERING, 34, 71–79. https://doi.org/10.1016/j.ymben.2015.12.006 Wheaton, G., Counts, J., Mukherjee, A., Kruh, J., & Kelly, R. (2015). [Review of The Confluence of Heavy Metal Biooxidation and Heavy Metal Resistance: Implications for Bioleaching by Extreme Thermoacidophiles]. MINERALS, 5(3), 397–451. https://doi.org/10.3390/min5030397 Keller, M. W., Lipscomb, G. L., Loder, A. J., Schut, G. J., Kelly, R. M., & Adams, M. W. W. (2015). A hybrid synthetic pathway for butanol production by a hyperthermophilic microbe. METABOLIC ENGINEERING, 27, 101–106. https://doi.org/10.1016/j.ymben.2014.11.004 Lewis, D. L., Notey, J. S., Chandrayan, S. K., Loder, A. J., Lipscomb, G. L., Adams, M. W. W., & Kelly, R. M. (2015). A mutant ('lab strain') of the hyperthermophilic archaeon Pyrococcus furiosus, lacking flagella, has unusual growth physiology. EXTREMOPHILES, 19(2), 269–281. https://doi.org/10.1007/s00792-014-0712-3 Hawkins, A. B., Adams, M. W. W., & Kelly, R. M. (2014). Conversion of 4-Hydroxybutyrate to Acetyl Coenzyme A and Its Anapleurosis in the Metallosphaera sedula 3-Hydroxypropionate/4-Hydroxybutyrate Carbon Fixation Pathway. APPLIED AND ENVIRONMENTAL MICROBIOLOGY, 80(8), 2536–2545. https://doi.org/10.1128/aem.04146-13 Tang, C., Saquing, C. D., Morton, S. W., Glatz, B. N., Kelly, R. M., & Khan, S. A. (2014). Cross-linked Polymer Nanofibers for Hyperthermophilic Enzyme Immobilization: Approaches to Improve Enzyme Performance. ACS APPLIED MATERIALS & INTERFACES, 6(15), 11899–11906. https://doi.org/10.1021/am5033633 Thorgersen, M. P., Lipscomb, G. L., Schut, G. J., Kelly, R. M., & Adams, M. W. W. (2014). Deletion of acetyl-CoA synthetases I and II increases production of 3-hydroxypropionate by the metabolically-engineered hyperthermophile Pyrococcus furiosus. METABOLIC ENGINEERING, 22, 83–88. https://doi.org/10.1016/j.ymben.2013.12.006 Jenney, F. E., Jr, Tachdijan, S., Chou, C.-J., Kelly, R. M., & Adams, M. W. W. (2007). Functional Genomics. In R. Cavicchioli (Ed.), Archaea: Molecular and Cellular Biology (pp. 434–462). https://doi.org/10.1128/9781555815516.ch20 Tang, C., Saquing, C. D., Sarin, P. K., Kelly, R. M., & Khan, S. A. (2014). Nanofibrous membranes for single-step immobilization of hyperthermophilic enzymes. JOURNAL OF MEMBRANE SCIENCE, 472, 251–260. https://doi.org/10.1016/j.memsci.2014.08.037 Keller, M., Loder, A., Basen, M., Izquierdo, J., Kelly, R. M., & Adams, M. W. W. (2014). Production of lignofuels and electrofuels by extremely thermophilic microbes. Biofuels, 5(5), 499–515. https://doi.org/10.1080/17597269.2014.996729 McCarthy, S., Ai, C., Wheaton, G., Tevatia, R., Eckrich, V., Kelly, R., & Blum, P. (2014). Role of an Archaeal PitA Transporter in the Copper and Arsenic Resistance of Metallosphaera sedula, an Extreme Thermoacidophile. JOURNAL OF BACTERIOLOGY, 196(20), 3562–3570. https://doi.org/10.1128/jb.01707-14 Basen, M., Schut, G. J., Nguyen, D. M., Lipscomb, G. L., Benn, R. A., Prybol, C. J., … Adams, M. W. W. (2014). Single gene insertion drives bioalcohol production by a thermophilic archaeon. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 111(49), 17618–17623. https://doi.org/10.1073/pnas.1413789111 Zurawski, J. V., Blumer-Schuette, S. E., Conway, J. M., & Kelly, R. M. (2014). The Extremely Thermophilic Genus Caldicellulosiruptor: Physiological and Genomic Characteristics for Complex Carbohydrate Conversion to Molecular Hydrogen. In Microbial BioEnergy: Hydrogen Production (pp. 177–195). https://doi.org/10.1007/978-94-017-8554-9_8 Schut, G. J., Lipscomb, G. L., Han, Y., Notey, J. S., Kelly, R. M., & Adams, M. M. W. (2014). The Order Thermococcales and the Family Thermococcaceae. In The Prokaryotes (pp. 363–383). https://doi.org/10.1007/978-3-642-38954-2_324 Hawkins, A. S., McTernan, P. M., Lian, H., Kelly, R. M., & Adams, M. W. W. (2013). [Review of Biological conversion of carbon dioxide and hydrogen into liquid fuels and industrial chemicals]. CURRENT OPINION IN BIOTECHNOLOGY, 24(3), 376–384. https://doi.org/10.1016/j.copbio.2013.02.017 Kataeva, I., Foston, M. B., Yang, S.-J., Pattathil, S., Biswal, A. K., Poole II, F. L., … Adams, M. W. W. (2013). Carbohydrate and lignin are simultaneously solubilized from unpretreated switchgrass by microbial action at high temperature. Energy & Environmental Science, 6(7), 2186. https://doi.org/10.1039/C3EE40932E Lipscomb, G. L., Schut, G. J., Thorgersen, M. P., Nixon, W. J., Kelly, R. M., & Adams, M. W. W. (2014). Engineering Hydrogen Gas Production from Formate in a Hyperthermophile by Heterologous Production of an 18-Subunit Membrane-bound Complex. JOURNAL OF BIOLOGICAL CHEMISTRY, 289(5), 2873–2879. https://doi.org/10.1074/jbc.m113.530725 Keller, M. W., Schut, G. J., Lipscomb, G. L., Menon, A. L., Iwuchukwu, I. J., Leuko, T. T., … Adams, M. W. W. (2013). Exploiting microbial hyperthermophilicity to produce an industrial chemical, using hydrogen and carbon dioxide. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 110(15), 5840–5845. https://doi.org/10.1073/pnas.1222607110 Frock, A. D., Montero, C. I., Blumer-Schuette, S. E., & Kelly, R. M. (2013). Stationary Phase and Nutrient Levels Trigger Transcription of a Genomic Locus Containing a Novel Peptide (TM1316) in the Hyperthermophilic Bacterium Thermotoga maritima. APPLIED AND ENVIRONMENTAL MICROBIOLOGY, 79(21), 6637–6646. https://doi.org/10.1128/aem.01627-13 Blumer-Schuette, S. E., Brown, S. D., Sander, K. B., Bayer, E. A., Kataeva, I., Zurawski, J. V., … Kelly, R. M. (2014). [Review of Thermophilic lignocellulose deconstruction]. FEMS MICROBIOLOGY REVIEWS, 38(3), 393–448. https://doi.org/10.1111/1574-6976.12044 Bielen, A. A. M., Verhaart, M. R. A., VanFossen, A. L., Blumer-Schuette, S. E., Stams, A. J. M., Oost, J., … Kengen, S. W. M. (2013). A thermophile under pressure: Transcriptional analysis of the response of Caldicellulosiruptor saccharolyticus to different H-2 partial pressures. INTERNATIONAL JOURNAL OF HYDROGEN ENERGY, 38(4), 1837–1849. https://doi.org/10.1016/j.ijhydene.2012.11.082 Blumer-Schuette, S. E., Giannone, R. J., Zurawski, J. V., Ozdemir, I., Ma, Q., Yin, Y., … Kelly, R. M. (2012). Caldicellulosiruptor Core and Pangenomes Reveal Determinants for Noncellulosomal Thermophilic Deconstruction of Plant Biomass. JOURNAL OF BACTERIOLOGY, 194(15), 4015–4028. https://doi.org/10.1128/jb.00266-12 Han, Y., Hawkins, A. S., Adams, M. W. W., & Kelly, R. M. (2012). Epimerase (Msed_0639) and Mutase (Msed_0638 and Msed_2055) Convert (S)-Methylmalonyl-Coenzyme A (CoA) to Succinyl-CoA in the Metallosphaera sedula 3-Hydroxypropionate/4-Hydroxybutyrate Cycle. APPLIED AND ENVIRONMENTAL MICROBIOLOGY, 78(17), 6194–6202. https://doi.org/10.1128/aem.01312-12 Frock, A. D., & Kelly, R. M. (2012). Extreme thermophiles: moving beyond single-enzyme biocatalysis. Current Opinion in Chemical Engineering, 1(4), 363–372. https://doi.org/10.1016/j.coche.2012.07.003 Frock, A. D., Gray, S. R., & Kelly, R. M. (2012). Hyperthermophilic Thermotoga Species Differ with Respect to Specific Carbohydrate Transporters and Glycoside Hydrolases. Applied and Environmental Microbiology, 78(6), 1978–1986. https://doi.org/10.1128/aem.07069-11 Hawkins, A. S., Han, Y., Bennett, R. K., Adams, M. W. W., & Kelly, R. M. (2013). Role of 4-Hydroxybutyrate-CoA Synthetase in the CO2 Fixation Cycle in Thermoacidophilic Archaea. JOURNAL OF BIOLOGICAL CHEMISTRY, 288(6), 4012–4022. https://doi.org/10.1074/jbc.m112.413195 Mukherjee, A., Wheaton, G. H., Blum, P. H., & Kelly, R. M. (2012). Uranium extremophily is an adaptive, rather than intrinsic, feature for extremely thermoacidophilic Metallosphaera species. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 109(41), 16702–16707. https://doi.org/10.1073/pnas.1210904109 Blumer-Schuette, S. E., Ozdemir, I., Mistry, D., Lucas, S., Lapidus, A., Cheng, J.-F., … Kelly, R. M. (2011). Complete Genome Sequences for the Anaerobic, Extremely Thermophilic Plant Biomass-Degrading Bacteria Caldicellulosiruptor hydrothermalis , Caldicellulosiruptor kristjanssonii , Caldicellulosiruptor kronotskyensis , Caldicellulosiruptor owensensis , and Caldicellulosiruptor lactoaceticus. Journal of Bacteriology, 193(6), 1483–1484. https://doi.org/10.1128/jb.01515-10 Hawkins, A. S., Han, Y., Lian, H., Loder, A. J., Menon, A. L., Iwuchukwu, I. J., … Kelly, R. M. (2011). Extremely Thermophilic Routes to Microbial Electrofuels. ACS CATALYSIS, 1(9), 1043–1050. https://doi.org/10.1021/cs2003017 VanFossen, A. L., Ozdemir, I., Zelin, S. L., & Kelly, R. M. (2011). Glycoside Hydrolase Inventory Drives Plant Polysaccharide Deconstruction by the Extremely Thermophilic Bacterium Caldicellulosiruptor saccharolyticus. BIOTECHNOLOGY AND BIOENGINEERING, 108(7), 1559–1569. https://doi.org/10.1002/bit.23093 Dam, P., Kataeva, I., Yang, S.-J., Zhou, F., Yin, Y., Chou, W., … Adams, M. W. W. (2011). Insights into plant biomass conversion from the genome of the anaerobic thermophilic bacterium Caldicellulosiruptor bescii DSM 6725. NUCLEIC ACIDS RESEARCH, 39(8), 3240–3254. https://doi.org/10.1093/nar/gkq1281 Ozdemir, I., Blumer-Schuette, S. E., & Kelly, R. M. (2012). S-Layer Homology Domain Proteins Csac_0678 and Csac_2722 Are Implicated in Plant Polysaccharide Deconstruction by the Extremely Thermophilic Bacterium Caldicellulosiruptor saccharolyticus. APPLIED AND ENVIRONMENTAL MICROBIOLOGY, 78(3), 768–777. https://doi.org/10.1128/aem.07031-11 Santa-Maria, M. C., Yencho, C. G., Haigler, C. H., Thompson, W. F., Kelly, R. M., & Sosinski, B. (2011). Starch Self-Processing in Transgenic Sweet Potato Roots Expressing a Hyperthermophilic alpha-Amylase. BIOTECHNOLOGY PROGRESS, 27(2), 351–359. https://doi.org/10.1002/btpr.573 Maezato, Y., Daugherty, A., Dana, K., Soo, E., Cooper, C., Tachdjian, S., … Blum, P. (2011). VapC6, a ribonucleolytic toxin regulates thermophilicity in the crenarchaeote Sulfolobus solfataricus. RNA, 17(7), 1381–1392. https://doi.org/10.1261/rna.2679911 Cobucci-Ponzano, B., Zorzetti, C., Strazzulli, A., Carillo, S., Bedini, E., Corsaro, M. M., … Moracci, M. (2011). A novel alpha-d-galactosynthase from Thermotoga maritima converts beta-d-galactopyranosyl azide to alpha-galacto-oligosaccharides. GLYCOBIOLOGY, 21(4), 448–456. https://doi.org/10.1093/glycob/cwq177 Harris, J. M., Adams, M., & Kelly, R. M. (2010). Enzymes, Extremely Thermophilic. In M. C. Flickinger (Ed.), Encyclopedia of Industrial Biotechnology. https://doi.org/10.1002/9780470054581.eib308 Gray, S. R., Adams, M. W. W., & Kelly, R. M. (2010). Extremely thermophilic microorganisms. In M. C. Flickinger (Ed.), Encyclopedia of Industrial Biotechnology: Bioprocess, Bioseparation, and Cell Technology (2nd ed., Vol. 5, pp. 3481–3499). NY: John Wiley and Sons. Ozdemir, I., & Kelly, R. M. (2010). Extremophiles (I. T. Horváth, Ed.). https://doi.org/10.1002/0471227617.eoc089.pub2 Auernik, K. S., & Kelly, R. M. (2010). Impact of Molecular Hydrogen on Chalcopyrite Bioleaching by the Extremely Thermoacidophilic Archaeon Metallosphaera sedula. APPLIED AND ENVIRONMENTAL MICROBIOLOGY, 76(8), 2668–2672. https://doi.org/10.1128/aem.02016-09 Harris, J. M., Epting, K. L., & Kelly, R. M. (2010). N-terminal Fusion of a Hyperthermophilic Chitin-Binding Domain to Xylose Isomerase from Thermotoga neapolitana Enhances Kinetics and Thermostability of Both Free and Immobilized Enzymes. BIOTECHNOLOGY PROGRESS, 26(4), 993–1000. https://doi.org/10.1002/btpr.416 Muddiman, D., Andrews, G., Lewis, D., Notey, J., & Kelly, R. (2010). Part I: characterization of the extracellular proteome of the extreme thermophile Caldicellulosiruptor saccharolyticus by GeLC-MS2. ANALYTICAL AND BIOANALYTICAL CHEMISTRY, 398(1), 377–389. https://doi.org/10.1007/s00216-010-3955-6 Andrews, G., Lewis, D., Notey, J., Kelly, R., & Muddiman, D. (2010, October). Part I: characterization of the extracellular proteome of the extreme thermophile Caldicellulosiruptor saccharolyticus by GeLC-MS2 (vol 398, pg 377, 2010). ANALYTICAL AND BIOANALYTICAL CHEMISTRY, Vol. 398, pp. 1837–1837. https://doi.org/10.1007/s00216-010-4102-0 Muddiman, D., Andrews, G., Lewis, D., Notey, J., & Kelly, R. (2010). Part II: defining and quantifying individual and co-cultured intracellular proteomes of two thermophilic microorganisms by GeLC-MS2 and spectral counting. ANALYTICAL AND BIOANALYTICAL CHEMISTRY, 398(1), 391–404. https://doi.org/10.1007/s00216-010-3929-8 Andrews, G., Lewis, D., Notey, J., Kelly, R., & Muddiman, D. (2010, October). Part II: defining and quantifying individual and co-cultured intracellular proteomes of two thermophilic microorganisms by GeLC-MS2 and spectral counting (vol 398, pg 391, 2010). ANALYTICAL AND BIOANALYTICAL CHEMISTRY, Vol. 398, pp. 1839–1839. https://doi.org/10.1007/s00216-010-4050-8 Blumer-Schuette, S. 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Chemical Engineering Education, 43(4), 257–264. Auernik, K. S., & Kelly, R. M. (2010). Physiological Versatility of the Extremely Thermoacidophilic Archaeon Metallosphaera sedula Supported by Transcriptomic Analysis of Heterotrophic, Autotrophic, and Mixotrophic Growth. APPLIED AND ENVIRONMENTAL MICROBIOLOGY, 76(3), 931–935. https://doi.org/10.1128/aem.01336-09 Santa-Maria, M. C., Chou, C.-J., Yencho, G. C., Haigler, C. H., Thompson, W. F., Kelly, R. M., & Sosinski, B. (2009). Plant cell calcium-rich environment enhances thermostability of recombinantly produced α-amylase from the hyperthermophilic bacterium Thermotoga maritime. Biotechnology and Bioengineering, 104(5), 947–956. https://doi.org/10.1002/bit.22468 Cooper, C. R., Daugherty, A. J., Tachdjian, S., Blum, P. H., & Kelly, R. M. (2009). Role of vapBC toxin–antitoxin loci in the thermal stress response of Sulfolobus solfataricus. Biochemical Society Transactions, 37(1), 123–126. https://doi.org/10.1042/BST0370123 Nichols, J. D., Johnson, M. R., Chou, C.-J., & Kelly, R. M. (2009). Temperature, not LuxS, mediates AI-2 formation in hydrothermal habitats. FEMS MICROBIOLOGY ECOLOGY, 68(2), 173–181. https://doi.org/10.1111/j.1574-6941.2009.00662.x Blumer-Schuette, S. E., Kataeva, I., Westpheling, J., Adams, M. W. W., & Kelly, R. M. (2008). [Review of Extremely thermophilic microorganisms for biomass conversion: status and prospects]. CURRENT OPINION IN BIOTECHNOLOGY, 19(3), 210–217. https://doi.org/10.1016/j.copbio.2008.04.007 Tachdjian, S., Shockley, K. R., Conners, S. B., & Kelly, R. M. (2008). Functional Genomics of Stress Response in Extremophilic Archaea. In P. Blum (Ed.), Archaea: New Models for Prokaryotic Biology. Norfolk, UK: Caister Academic Press. Chou, C.-J., Jenney, F. E., Jr., Adams, M. W. W., & Kelly, R. M. (2008). [Review of Hydrogenesis in hyperthermophilic microorganisms: Implications for biofuels]. METABOLIC ENGINEERING, 10(6), 394–404. https://doi.org/10.1016/j.ymben.2008.06.007 Werken, H. J. G., Verhaart, M. R. A., VanFossen, A. L., Willquist, K., Lewis, D. L., Nichols, J. D., … Kengen, S. W. M. (2008). Hydrogenomics of the Extremely Thermophilic Bacterium Caldicellulosiruptor saccharolyticus. APPLIED AND ENVIRONMENTAL MICROBIOLOGY, 74(21), 6720–6729. https://doi.org/10.1128/AEM.00968-08 Auernik, K. S., & Kelly, R. M. (2008). Identification of Components of Electron Transport Chains in the Extremely Thermoacidophilic Crenarchaeon Metallosphaera sedula through Iron and Sulfur Compound Oxidation Transcriptomes. APPLIED AND ENVIRONMENTAL MICROBIOLOGY, 74(24), 7723–7732. https://doi.org/10.1128/AEM.01545-08 Auernik, K. S., Cooper, C. R., & Kelly, R. M. (2008). [Review of Life in hot acid: Pathway analyses in extremely thermoacidophilic archaea]. CURRENT OPINION IN BIOTECHNOLOGY, 19(5), 445–453. https://doi.org/10.1016/j.copbio.2008.08.001 Young, D. D., Nichols, J., Kelly, R. M., & Deiters, A. (2008). Microwave activation of enzymatic catalysis. JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 130(31), 10048-+. https://doi.org/10.1021/ja802404g VanFossen, A. L., Lewis, D. L., Nichols, J. D., & Kelly, R. M. (2008). Polysaccharide Degradation and Synthesis by Extremely Thermophilic Anaerobes. Annals of the New York Academy of Sciences, 1125(1), 322–337. https://doi.org/10.1196/annals.1419.017 Michel, J. K., & Kelly, R. M. (2007). Archaeal 20S Proteasome: A Simple and Thermostable Model System for the Core Particle. In F. Robb, G. Antranikian, D. Grogan, & A. Driessen (Eds.), Thermophiles (pp. 347–360). https://doi.org/10.1201/9781420008852-29 Comfort, D. A., Bobrov, K. S., Ivanen, D. R., Shabalin, K. A., Harris, J. M., Kulminskaya, A. A., … Kelly, R. M. (2007). Biochemical analysis of Thermotoga maritima GH36 alpha-galactosidase (TmGalA) confirms the mechanistic commonality of clan GH-D glycoside hydrolases. BIOCHEMISTRY, 46(11), 3319–3330. https://doi.org/10.1021/bi061521n Haugh, J. M., & Kelly, R. M. (2007). Biochemical/Biomolecular engineering. In McGraw-Hill encyclopedia of science & technology (10th ed.). New York: McGraw-Hill. Comfort, D. A., Chou, C.-J., Conners, S. B., VanFossen, A. L., & Kelly, R. M. (2008). Functional-genomics-based identification and characterization of open reading frames encoding alpha-glucoside-processing enzymes in the hyperthermophilic archaeon Pyrococcus furiosus. APPLIED AND ENVIRONMENTAL MICROBIOLOGY, 74(4), 1281–1283. https://doi.org/10.1128/AEM.01920-07 Chou, C.-J., Shockley, K. R., Conners, S. B., Lewis, D. L., Comfort, D. A., Adams, M. W. W., & Kelly, R. M. (2007). Impact of substrate glycoside linkage. and elemental sulfur on bioenergetics, of and hydrogen production by the hyperthermophilic Archaeon Pyrococcus furiosus. APPLIED AND ENVIRONMENTAL MICROBIOLOGY, 73(21), 6842–6853. https://doi.org/10.1128/AEM.00597-07 Kaczowka, S. J., Madding, L. S., Epting, K. L., Kelly, R. M., Cianciolo, G. J., & Pizzo, S. V. (2008). Probing the stability of native and activated forms of alpha(2)-macroglobulin. INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES, 42(1), 62–67. https://doi.org/10.1016/j.ijbiomac.2007.09.019 Montero, C. I., Johnson, M. R., Chou, C.-J., Conners, S. B., Geouge, S. G., Tachdjian, S., … Kelly, R. M. (2007). Responses of wild-type and resistant strains of the hyperthermophilic bacterium Thermotoga maritima to chloramphenicol challenge. APPLIED AND ENVIRONMENTAL MICROBIOLOGY, 73(15), 5058–5065. https://doi.org/10.1128/AEM.00453-07 Mahammad, S., Comfort, D. A., Kelly, R. M., & Khan, S. A. (2007). Rheological properties of guar galactomannan solutions during hydrolysis with galactomannanase and alpha-galactosidase enzyme mixtures. BIOMACROMOLECULES, 8(3), 949–956. https://doi.org/10.1021/bm0608232 Auernik, K. S., Maezato, Y., Blum, P. H., & Kelly, R. M. (2008). 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Isolation and characterization of Thermococcus barossii, sp. nov., a hyperthermophilic Archaeon isolated from a hydrothermal vent flange formation. SYSTEMATIC AND APPLIED MICROBIOLOGY, 21(1), 40–49. https://doi.org/10.1016/S0723-2020(98)80007-6 Kowalski, J. M., Kelly, R. M., Konisky, J., Clark, D. S., & Wittrup, K. D. (1998). Purification and functional characterization of a chaperone from Methanococcus jannaschii. SYSTEMATIC AND APPLIED MICROBIOLOGY, 21(2), 173–178. https://doi.org/10.1016/S0723-2020(98)80021-0 Hicks, P. M., & Kelly, R. M. (1998). Pyrococcus furiosus Protease I (PfpI). In F. Woessner, N. Rawlings, & A. Barrett (Eds.), Handbook of Proteolytic Enzymes. London: Academic Press Limited. Bauer, M. W., & Kelly, R. M. (1998). The family 1 beta-glucosidases from Pyrococcus furiosus and Agrobacterium faecalis share a common catalytic mechanism. BIOCHEMISTRY, 37(49), 17170–17178. https://doi.org/10.1021/bi9814944 Hess, J. M., Tchernajenko, V., Vieille, C., Zeikus, J. G., & Kelly, R. M. (1998). Thermotoga neapolitana homotetrameric xylose isomerase is expressed as a catalytically active and thermostable dimer in Escherichia coli. Applied and Environmental Microbiology, 64(7), 2357–2360. Han, C. J., Park, S. H., & Kelly, R. M. (1997). Acquired thermotolerance and stressed-phase growth of the extremely thermoacidophilic Archaeon Metallosphaera sedula in continuous culture. Applied and Environmental Microbiology, 63(6), 2391–2396. Muralidharan, V., Rinker, K. D., Hirsh, I. S., Bouwer, E. J., & Kelly, R. (1997). Hydrogen transfer between methanogens and fermentative heterotrophs in hyperthermophilic cocultures. Biotechnology and Bioengineering, 56(3), 268–278. https://doi.org/10.1002/(sici)1097-0290(19971105)56:3<268::aid-bit4>3.0.co;2-h Bauer, M. W., Bauer, S. H., & Kelly, R. M. (1997). Purification and Characterization of a Proteasome from the Hyperthermophilic Archaeon Pyrococcus furiosus. Applied and Environmental Microbiology, 63(3), 1160–1164. https://doi.org/10.1128/aem.63.3.1160-1164.1997 Duffaud, G. D., McCutchen, C. M., Leduc, P., Parker, K. N., & Kelly, R. M. (1997). Purification and characterization of extremely thermostable beta mannanase, beta mannosidase, and alpha galactosidase from the hyperthermophilic eubacterium Thermotoga neapolitana. Applied and Environmental Microbiology, 63(1), 169–177. Halio, S. B., Bauer, M. W., Mukund, S., Adams, M. W. W., & Kelly, R. M. (1997). Purification and characterization of two functional forms of intracellular protease PFPI from the hyperthermophilic Archaeon Pyrococcus furiosus. Applied and Environmental Microbiology, 63(1), 289–295. Luhm, R. A., d'Hennezel, O. B., Duffaud, G. D., Jolly, J. F., Kelly, R. M., & Ting, E. Y. (1997). Purified Thermococcus barossii DNA polymerase. Washington, DC: U.S. Patent and Trademark Office. Tayal, A., Kelly, R. M., & Khan, S. A. (1997). Viscosity Reduction Of Hydraulic Fracturing Fluids Through Enzymatic Hydrolysis. SPE Journal, 2(02), 204–212. https://doi.org/10.2118/38432-pa Bauer, M. W., Bylina, E. J., Swanson, R. V., & Kelly, R. M. (1996). Comparison of a β-Glucosidase and a β-Mannosidase from the Hyperthermophilic Archaeon Pyrococcus furiosus. Journal of Biological Chemistry, 271(39), 23749–23755. https://doi.org/10.1074/jbc.271.39.23749 Kelly, R. M. (1996). Confessions of a graduate student recruiter. Chemical Engineering Education, 30(4), 262–265. Rinker, K. D., & Kelly, R. M. (1996). Growth Physiology of the Hyperthermophilic Archaeon Thermococcus litoralis: Development of a Sulfur-Free Defined Medium, Characterization of an Exopolysaccharide, and Evidence of Biofilm Formation. Applied and Environmental Microbiology, 62(12), 4478–4485. https://doi.org/10.1128/aem.62.12.4478-4485.1996 Bauer, M. W., Halio, S. B., & Kelly, R. M. (1996). Proteases and Glycosyl Hydrolases from Hyperthermophilic Microorganisms. 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(1995). xylA cloning and sequencing and biochemical characterization of xylose isomerase from Thermotoga neapolitana. Applied and Environmental Microbiology, 61(5), 1867–1875. https://doi.org/10.1128/aem.61.5.1867-1875.1995 Kelly, R. M., Wittrup, K. D., & Karkare, S. (Eds.). (1994). Biochemical Engineering VIII - Proceedings. In Annals of the New York Academy of Sciences (Vol. 745). New York: New York Academy of Sciences. Kelly, R. M., Peeples, T. L., Halio, S. B., Rinker, K. D., & Duffaud, G. D. (1994). Extremely Thermophilic Microorganisms: Metabolic strategies, genetic characteristics and biotechnological potential of extremely thermophilic microorganisms. Annals of the New York Academy of Sciences, 745(1), 409–425. https://doi.org/10.1111/j.1749-6632.1994.tb44393.x Citations: 5 Adams, M. W. W., Baross, J. A., & Kelly, R. M. (1994). Life in boiling water. Chemistry in Britain, 30(7), 555–558. KELLY, R. M., & ADAMS, M. W. W. (1994). [Review of METABOLISM IN HYPERTHERMOPHILIC MICROORGANISMS]. ANTONIE VAN LEEUWENHOEK INTERNATIONAL JOURNAL OF GENERAL AND MOLECULAR MICROBIOLOGY, 66(1-3), 247–270. https://doi.org/10.1007/BF00871643 Adams, M. W. W., & Kelly, R. M. (1994). Thermostability and thermoactivity of enzymes from hyperthermophilic archaea. Bioorganic & Medicinal Chemistry, 2(7), 659–667. https://doi.org/10.1016/0968-0896(94)85015-1 Kelly, R. M. (1993). Biocatalysis at extreme temperatures. In G. Georgiou & I. Glowinski (Eds.), Research opportunities in biomolecular engineering : the interface between chemical engineering and biology, December 7-8, 1992, proceedings. Bethesda, MD: NIH Press. Kelly, R. M., & Whitesides, G. (1993). Biocatalysis: An overview. In G. Georgiou & I. Glowinski (Eds.), Research opportunities in biomolecular engineering : the interface between chemical engineering and biology, December 7-8, 1992, proceedings. Bethesda, MD: NIH Press. Schicho, R. N., Ma, K., Adams, M. W., & Kelly, R. M. (1993). Bioenergetics of sulfur reduction in the hyperthermophilic archaeon Pyrococcus furiosus. Journal of Bacteriology, 175(6), 1823–1830. https://doi.org/10.1128/jb.175.6.1823-1830.1993 Peeples, T. L., & Kelly, R. M. (1993). Bioenergetics of the metal/sulfur-oxidizing extreme thermoacidophile, Metallosphaera sedula. Fuel, 72(12), 1619–1624. https://doi.org/10.1016/0016-2361(93)90345-3 Brown, S. H., & Kelly, R. M. (1993). Characterization of Amylolytic Enzymes, Having Both α-1,4 and α-1,6 Hydrolytic Activity, from the Thermophilic Archaea Pyrococcus furiosus and Thermococcus litoralis. Applied and Environmental Microbiology, 59(8), 2614–2621. https://doi.org/10.1128/aem.59.8.2614-2621.1993 Kelly, R. M., & Brown, S. H. (1993). Enzymes from high-temperature microorganisms. Current Opinion in Biotechnology, 4(2), 188–192. https://doi.org/10.1016/0958-1669(93)90123-e Ma, K., Schicho, R. N., Kelly, R. M., & Adams, M. W. (1993). Hydrogenase of the hyperthermophile Pyrococcus furiosus is an elemental sulfur reductase or sulfhydrogenase: evidence for a sulfur-reducing hydrogenase ancestor. Proceedings of the National Academy of Sciences, 90(11), 5341–5344. https://doi.org/10.1073/pnas.90.11.5341 Schicho, R. N., Snowden, L. J., Mukund, S., Park, J.-B., Adams, M. W. W., & Kelly, R. M. (1993). Influence of tungsten on metabolic patterns in Pyrococcus furiosus, a hyperthermophilic archaeon. Archives of Microbiology, 159(4), 380–385. https://doi.org/10.1007/bf00290921 Starnes, R. L., Kelly, R. M., & Brown, S. H. (1993). Method for glucose isomerization using xylose isomerase purified from Thermotoga maritima and Thermotoga neapolitana (US Patent No. 5,268,280). Starnes, R. L., Kelly, R. M., & Brown, S. H. (1993). Novel Isomerization Enzymes (U.S. Patent No. 5,219,751). Kelly, R. M., Robinson, A. S., Blumentals, I. I., Brown, S. H., & Anfinsen, C. B. (1993). 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Biocatalysis at Extreme Temperatures. 7. https://doi.org/10.1021/bk-1992-0498 Kelly, R. M., Brown, S. H., Blumentals, I. I., & Adams, M. W. W. (1992). Characterization of Enzymes from High-Temperature Bacteria. In ACS Symposium Series (pp. 23–41). https://doi.org/10.1021/bk-1992-0498.ch003 Adams, M. W. W., Park, J.-B., Mukund, S., Blamey, J., & Kelly, R. M. (1992). Metabolic Enzymes from Sulfur-Dependent, Extremely Thermophilic Organisms. In ACS Symposium Series: Vol. 498. Biocatalysis at Extreme Temperatures (pp. 4–22). https://doi.org/10.1021/bk-1992-0498.ch002 Kelly, R. M., Blumentals, I. I., Snowde, L. J., & Adams, M. W. W. (1992). Physiological and Biochemical Characteristics of Pyrococcus furiosus, a Hyperthermophilic Archaebacterium. Annals of the New York Academy of Sciences, 665(1 Biochemical E), 309–319. https://doi.org/10.1111/j.1749-6632.1992.tb42594.x Snowden, L. J., Blumentals, I. I., & Kelly, R. M. (1992). Regulation of Proteolytic Activity in the Hyperthermophile Pyrococcus furiosus. Applied and Environmental Microbiology, 58(4), 1134–1141. https://doi.org/10.1128/aem.58.4.1134-1141.1992 Olson, G. J., & Kelly, R. M. (1991). Chemical and microbiological problems associated with research on the biodesulfurization of coal. A review. Resources, Conservation and Recycling, 5(2-3), 183–193. https://doi.org/10.1016/0921-3449(91)90024-i Peeples, T. L., Hirosue, S., Olson, G. J., & Kelly, R. M. (1991). Coal sulphur transformations monitored by hyperthermophilic archaebacteria. Fuel, 70(5), 599–604. https://doi.org/10.1016/0016-2361(91)90173-8 Muralidharan, V., Hirsh, I. S., Suy, I., Bouwer, E. J., & Kelly, R. M. (1991). Mixed Cultures of High Temperature Bacteria: Prospects for Bioprocessing of Fossil Fuels. Proceedings of the 2nd International Conference on the Biological Processing of Fossil Fuels. Presented at the 2nd International Conference on the Biological Processing of Fossil Fuels. Brown, S. H., Costantino, H. R., & Kelly, R. M. (1990). Characterization of Amylolytic Enzyme Activities Associated with the Hyperthermophilic Archaebacterium Pyrococcus furiosus. Applied and Environmental Microbiology, 56(7), 1985–1991. https://doi.org/10.1128/aem.56.7.1985-1991.1990 Blumentals, I. I., Robinson, A. S., & Kelly, R. M. (1990). Characterization of sodium dodecyl sulfate-resistant proteolytic activity in the hyperthermophilic archaebacterium Pyrococcus furiosus. Applied and Environmental Microbiology, 56(7), 1992–1998. https://doi.org/10.1128/aem.56.7.1992-1998.1990 Reilly, J. T., Schubert, C. N., Lindner, J. R., Donohue, M. D., & Kelly, R. M. (1990). EFFECT OF HETEROCYCLIC AMINE ADDITIVES ON THE ABSORPTION RATES OF CARBONYL SULFIDE AND CARBON DIOXIDE IN AQUEOUS METHYLDIETHANOLAMINE SOLUTIONS. Chemical Engineering Communications, 93(1), 181–191. https://doi.org/10.1080/00986449008911445 Pihl, T. D., Schicho, R. N., Black, L. K., Schulman, B. A., Maier, R. J., & Kelly, R. M. (1990). Hydrogen-Sulfur Autotrophy in the Hyperthermophilic Archaebacterium,Pyrodictium brockii. Biotechnology and Genetic Engineering Reviews, 8(1), 345–378. https://doi.org/10.1080/02648725.1990.10647874 Olson, G. J., & Kelly, R. M. (1990). Microbiological Processing of Coal. In D. L. Wise (Ed.), Biotechnology Applied to Fossil Fuels. New York: Marcel Dekker. Clark, D. S., & Kelly, R. M. (1990). Microorganisms at extreme temperatures and pressures: Engineering insights. CHEMTECH, 20(11), 641–648. Costantino, H. R., Brown, S. H., & Kelly, R. M. (1990). Purification and characterization of an alpha-glucosidase from a hyperthermophilic archaebacterium, Pyrococcus furiosus, exhibiting a temperature optimum of 105 to 115 degrees C. Journal of Bacteriology, 172(7), 3654–3660. https://doi.org/10.1128/jb.172.7.3654-3660.1990 Blumentals, I. I., Itoh, M., Olson, G. J., & Kelly, R. M. (1990). Role of Polysulfides in Reduction of Elemental Sulfur by the Hyperthermophilic Archaebacterium Pyrococcus furiosus. Applied and Environmental Microbiology, 56(5), 1255–1262. https://doi.org/10.1128/aem.56.5.1255-1262.1990 Kelly, R. M., & Olson, G. J. (1990). Specific Biocatalysis for Coal Sulfur Speciation and Removal (Electric Power Research Institute Interim Report No. ER/GS-6624). Blumentals, I. I., Brown, S. H., Schicho, R. N., Skaja, A. K., Costantino, H. R., & Kelly, R. M. (1990). The Hyperthermophilic Archaebacterium, Pyrococcus furiosus. Annals of the New York Academy of Sciences, 589(1 Biochemical E), 301–314. https://doi.org/10.1111/j.1749-6632.1990.tb24254.x Olson, G. J., Peeples, T. L., Blumentals, I. I., Schicho, R. N., Brown, S. H., & Kelly, R. M. (1989). Bioprocessing of Fossil Fuels Using Hyperthermophilic Archaebacteria. Proceedings of the 14th Annual EPRI Conference on Fuel Science and Conversion. Presented at the 14th Annual EPRI Conference on Fuel Science and Conversion, Palo Alto, CA. Blumentals, I. I., Kelly, R. M., & Shiloach, J. (1989). Bioreactor operation for the production of exotoxin A byPseudomonas aeruginosa. Biotechnology and Bioengineering, 34(9), 1214–1220. https://doi.org/10.1002/bit.260340913 Pihl, T. D., Schicho, R. N., Kelly, R. M., & Maier, R. J. (1989). Characterization of hydrogen-uptake activity in the hyperthermophile Pyrodictium brockii. Proceedings of the National Academy of Sciences, 86(1), 138–141. https://doi.org/10.1073/pnas.86.1.138 Brown, S. H., & Kelly, R. M. (1989). Cultivation Techniques for Hyperthermophilic Archaebacteria: Continuous Culture of Pyrococcus furiosus at Temperatures near 100�C. Applied and Environmental Microbiology, 55(8), 2086–2088. https://doi.org/10.1128/aem.55.8.2086-2088.1989 Malik, B., Su, W.-w., Wald, H. L., Blumentals, I. I., & Kelly, R. M. (1989). Growth and gas production for hyperthermophilic archaebacterium,Pyrococcus furiosus. Biotechnology and Bioengineering, 34(8), 1050–1057. https://doi.org/10.1002/bit.260340805 Schicho, R. N., Brown, S. H., Olson, G. J., Parks, E. J., & Kelly, R. M. (1989). Probing coals for non-pyritic sulphur using sulphur-metabolizing mesophilic and hyperthermophilic bacteria. Fuel, 68(11), 1368–1375. https://doi.org/10.1016/0016-2361(89)90032-x Kelly, R. M., Schicho, R. N., Brown, S. H., Soisson, J. P., Blumentals, I. I., Olson, G. J., & Parks, E. J. (1988). Biological Sulfur Oxidation and Reduction for Coal Sulfur Speciation and Desulfurization. Proceedings of the 13th Annual EPRI Conference on Fuel Science and Conversion. Presented at the 13th Annual EPRI Conference on Fuel Science and Conversion, Santa Clara, CA. Pihl, T. D., Schicho, R. N., Kelly, R. M., & Maier, R. J. (1988). Characterization of the H2-Uptake Hydrogenase Activity from the Extreme Thermophile Pyrodictium brockii. Presented at the First International IGT Symposium on Gas, Oil, and Coal Biotechnology, New Orleans, Louisiana. Johnston, J. B., Hannah, R. E., Cunningham, V. L., Daggy, B. P., Sturm, F. J., & Kelly, R. M. (1988). Destruction of Pharmaceutical and Biopharmaceutical Wastes by the Modar Supercritical Water Oxidation Process. Nature Biotechnology, 6(12), 1423–1427. https://doi.org/10.1038/nbt1288-1423 Parameswaran, A. K., Schicho, R. N., Soisson, J. P., & Kelly, R. M. (1988). Effect of hydrogen and carbon dioxide partial pressures on growth and sulfide production of the extremely thermophilic archaebacterium Pyrodictium brockii. Biotechnology and Bioengineering, 32(4), 438–443. https://doi.org/10.1002/bit.260320405 Su, W.-W., & Kelly, R. M. (1988). Effect of hyperbaric oxygen and carbon dioxide on heterotrophic growth of the extreme thermophileSulfolobus acidocaldarius. Biotechnology and Bioengineering, 31(7), 750–754. https://doi.org/10.1002/bit.260310720 Parameswaran, A. K., Su, W.-wen, Schicho, R. N., Provan, C. N., Malik, B., & Kelly, R. M. (1988). Engineering considerations for growth of bacteria at temperatures around 100°C. Applied Biochemistry and Biotechnology, 18(1), 53–73. https://doi.org/10.1007/bf02930817 Kelly, R. M., & Deming, J. W. (1988). Extremely Thermophilic Archaebacteria: Biological and Engineering Considerations. Biotechnology Progress, 4(2), 47–62. https://doi.org/10.1002/btpr.5420040202 Lindner, J. R., Schubert, C. N., & Kelly, R. M. (1988). Influence of hydrodynamics on physical and chemical gas absorption in packed columns. Industrial & Engineering Chemistry Research, 27(4), 636–642. https://doi.org/10.1021/ie00076a018 Yeh, T. Y., Kelly, R. M., Cox, J., & Olson, G. J. (1988). Significance of cell fluorescence color of acridine orange-stained Thiobacillus ferrooxidans under epifluoresence microscopy. Science and Technology Letters. Presented at the Biohydrometa Conference, Warwick. Blumentals, I. I., Kelly, R. M., Gorziglia, M., Kaufman, J. B., & Shiloach, J. (1987). Development of a defined medium and two-step culturing method for improved exotoxin A yields from Pseudomonas aeruginosa. Applied and Environmental Microbiology, 53(9), 2013–2020. https://doi.org/10.1128/aem.53.9.2013-2020.1987 Blumentals, I. I., Skaja, A. K., Kelly, R. M., Clem, T. R., & Shiloach, J. (1987). Effect of Culturing Conditions on the Production of Exotoxin A by Pseudomonas aeruginosa. Annals of the New York Academy of Sciences, 506(1 Biochemical E), 663–668. https://doi.org/10.1111/j.1749-6632.1987.tb23864.x Sturm, F. J., Parameswaran, A. K., Provan, C. N., & Kelly, R. M. (1987). Growth of Extremely Thermophilic Archaebacteria under Elevated Hyperbaric Conditions. Annals of the New York Academy of Sciences, 506(1 Biochemical E), 51–66. https://doi.org/10.1111/j.1749-6632.1987.tb23809.x Sturm, F. J., Hurwitz, S. A., Deming, J. W., & Kelly, R. M. (1987). Growth of the extreme thermophileSulfolobus acidocaldarius in a hyperbaric helium bioreactor. Biotechnology and Bioengineering, 29(9), 1066–1074. https://doi.org/10.1002/bit.260290905 Parameswaran, A. K., Provan, C. N., Sturm, F. J., & Kelly, R. M. (1987). Sulfur Reduction by the Extremely Thermophilic Archaebacterium Pyrodictium occultum. Applied and Environmental Microbiology, 53(7), 1690–1693. https://doi.org/10.1128/aem.53.7.1690-1693.1987 Yeh, T. Y., Godshalk, J. R., Olson, G. J., & Kelly, R. M. (1987). Use of epifluorescence microscopy for characterizing the activity ofThiobacillus Ferrooxidans on iron pyrite. Biotechnology and Bioengineering, 30(1), 138–146. https://doi.org/10.1002/bit.260300119 Schubert, C. N., Lindner, J. R., & Kelly, R. M. (1986). Experimental methods for measuring static liquid holdup in packed columns. AIChE Journal, 32(11), 1920–1923. https://doi.org/10.1002/aic.690321119 Shiloach, J., Kaufman, J. B., & Kelly, R. M. (1986). Hollow Fiber Microfiltration Methods for Recovery of Rat Basophilic Leukemia Cells (RBL-2H3) From Tissue Culture Media. Biotechnology Progress, 2(4), 230–233. https://doi.org/10.1002/btpr.5420020411 Olson, G. J., & Kelly, R. M. (1986). Microbiological Metal Transformations: Biotechnological Applications and Potential. Biotechnology Progress, 2(1), 1–15. https://doi.org/10.1002/btpr.5420020104 Rousseau, R. W., Ferrell, J. K., & Kelly, R. M. (1985). Conditioning Coal Gas with Refrigerated Methanol in a System of Packed Columns. Chemical Engineering Communications, 34(1-6), 27–35. https://doi.org/10.1080/00986448508911184 Kelly, R. M., Rousseau, R. W., & Ferrell, J. K. (1984). Design of packed, adiabatic absorbers: physical absorption of acid gases in methanol. Industrial & Engineering Chemistry Process Design and Development, 23(1), 102–109. https://doi.org/10.1021/i200024a017 Kelly, R. M., Rousseau, R. W., & Ferrell, J. K. (1983). Coal Gasification/Gas Cleanup Test Facility. Volume 4. A Mathematical Model of the Packed Column Acid Gas Absorber (No. EPA/600/7-83/053). Washington, D.C.: U.S. Environmental Protection Agency. Ferrell, J. K., Felder, R. M., Rousseau, R. W., Ganesan, S., Kelly, R. M., McCue, J. C., & Purdy, M. J. (1982). Coal Gasification/Gas Cleanup Test Facility, Vol III: Environmental Assessment of Operation with New Mexico Subbituminous Coal and Chilled Methanol (No. EPA-600/7-82-054). Washington, D.C.: U.S. Environmental Protection Agency. Ferrell, J. K., Felder, R. M., Rousseau, R. W., Ganesan, S., Kelly, R. M., McCue, J. C., & Purdy, M. J. (1982). Coal Gasification/Gas Cleanup Test Facility: Vol II: Environmental Assessment of Operation with Devolatilized Bituminous Coal and Chilled Methanol (No. EPA-600/7-82-023). Washington, D.C.: U.S. Environmental Protection Agency. Kelly, R. M., Rousseau, R. W., & Ferrell, J. K. (1981). Physical Absorption of CO2and Sulfur Gases from Coal Gasification: Simulation and Experimental Results. 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