Works (4)
Updated: July 5th, 2023 14:46
2022 article
The Cyanotoxin 2,4-DAB Reduces Viability and Causes Behavioral and Molecular Dysfunctions Associated with Neurodegeneration in Larval Zebrafish
Martin, R. M., Bereman, M. S., & Marsden, K. C. (2022, January 14). NEUROTOXICITY RESEARCH, Vol. 40.
author keywords: Cyanotoxins; Mixtures; 2,4-DAB; Zebrafish; Behavior; Proteomics
MeSH headings : Amino Acids, Diamino / toxicity; Animals; Cyanobacteria; Cyanobacteria Toxins; Isomerism; Larva; Neurotoxicity Syndromes; Neurotoxins / toxicity; Zebrafish
TL;DR:
Together, the data demonstrate that BMAA and its isomers AEG and 2,4-DAB cause neurotoxic effects in vivo, with 2, 4- DAB as the most potent of the three in the zebrafish model.
(via Semantic Scholar)
open access via link.springer.com (publisher PDF)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, ORCID, NC State University Libraries
Added: January 15, 2022
2020 journal article
BMAA and MCLR Interact to Modulate Behavior and Exacerbate Molecular Changes Related to Neurodegeneration in Larval Zebrafish
TOXICOLOGICAL SCIENCES, 179(2), 251–261.
author keywords: cyanotoxins; mixtures; zebrafish; behavior; proteomics
MeSH headings : Amino Acids, Diamino / toxicity; Animals; Cyanobacteria Toxins; Larva; Proteomics; Zebrafish
TL;DR:
This study evaluates the neurotoxic effects of a mixture of two co-occurring cyanotoxins, β-methylamino-L-alanine (BMAA) and microcystin leucine and arginine (MCLR), using the larval zebrafish model to reveal that BMAA and MCLR interact in vivo to enhance neurotoxicity.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
Sources: Web Of Science, ORCID, NC State University Libraries
Added: December 15, 2020
2019 journal article
Mixture designs to investigate adverse effects upon co-exposure to environmental cyanotoxins
Toxicology, 421, 74–83.
author keywords: Cyanotoxins; Mixture design; Interaction; Environmental exposure; Proteomics
MeSH headings : Animals; Bacterial Toxins / toxicity; Cell Line; Cell Survival / drug effects; Cyanobacteria; Drug Interactions; Mice; No-Observed-Adverse-Effect Level; Proteome / drug effects; Risk Assessment / methods; Toxicity Tests / methods
TL;DR:
The results highlight the need to study combinations of cyanotoxins when investigating the link between cyanobacteria and neurodegenerative pathologies and the application of design of experiment (DoE) as an efficient methodology to study mixtures of relevant environmental toxins.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
6. Clean Water and Sanitation
(OpenAlex)
Sources: Web Of Science, Crossref
Added: April 20, 2020
2017 journal article
Exposure to BMAA mirrors molecular processes linked to neurodegenerative disease
Proteomics, 17(17-18).
Source: NC State University Libraries
Added: August 6, 2018
Citation Index includes data from a number of different sources. If you have questions about the sources of data in the Citation Index or need a set of data which is free to re-distribute, please contact us.
Certain data included herein are derived from the Web of Science© and InCites© (2024) of Clarivate Analytics. All rights reserved. You may not copy or re-distribute this material in whole or in part without the prior written consent of Clarivate Analytics.